OOIR: Observatory of International Research

Papers

(The H4-Index of Bioorganic & Medicinal Chemistry is 29. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
A comprehensive review on the biological interest of quinoline and its derivatives	298
Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors	123
An insight into the medicinal attributes of berberine derivatives: A review	76
Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells	74
Application of marine natural products in drug research	71
Structural modification aimed for improving solubility of lead compounds in early phase drug discovery	66
Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase	60
Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors	60
The research progress in and perspective of potential fungicides: Succinate dehydrogenase inhibitors	60
Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens	60
Recent advances on synthesis and biological activities of aurones	59
Pyridine alkaloids with activity in the central nervous system	56
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity	55
Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer	49
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer’s disease	49
[1,2,4]Triazolo[4,3-c]quinazoline and bis([1,2,4]triazolo)[4,3-a:4′,3′-c]quinazoline derived DNA intercalators: Design, synthesis, in silico ADMET profile, molecular docking and anti-proliferative eva	47
Indole acrylonitriles as potential anti-hyperglycemic agents: Synthesis, α-glucosidase inhibitory activity and molecular docking studies	46
Covalent peptides and proteins for therapeutics	43
The natural-based optimization of kojic acid conjugated to different thio-quinazolinones as potential anti-melanogenesis agents with tyrosinase inhibitory activity	42
Boron-Containing heterocycles as promising pharmacological agents	38
Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases	38
Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells	36
Recent progress in covalent warheads for in vivo targeting of endogenous proteins	35
Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models	35
Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol	34

Bioorthogonal strategies for the in vivo synthesis or release of drugs	33
MCC950, a NLRP3 inhibitor, ameliorates lipopolysaccharide-induced lung inflammation in mice	33
The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR opti	32
Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study	29
Glycyrrhetinic acid derivatives as Zika virus inhibitors: Synthesis and antiviral activity in vitro	29