OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Subscription and Copyright Information	354
Subscription and Copyright Information	199
Subscription and Copyright Information	172
Adding post-translational modifications and protein–protein interactions to protein schematics	168
Advisory Board and Contents	158
Multiplayer virtual reality for understanding biomolecular structures	148
Did circular DNA shape the evolution of mammalian genomes?	104
Conserved signaling gears that sustain circadian clock robustness	104
From lead to market: chemical approaches to transform peptides into therapeutics	101
Decoding ceramide function: how localization shapes cellular fate and how to study it	98
Harnessing the power of peptides: advances and collaborations in biochemistry	95
Advisory Board and Contents	94
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	84
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	82
Understanding peptide hormones: from precursor proteins to bioactive molecules	79
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	78
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	77
Novel machine learning approaches revolutionize protein knowledge	77
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	76
Exploiting enzyme evolution for computational protein design	72
Cellular oxidants and the proteostasis network: balance between activation and destruction	71
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	69
Molecular mechanisms of heat shock factor 1 regulation	65
Transcription-coupled global genomic repair in E. coli	64
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	63

Determining and interpreting protein lifetimes in mammalian tissues	63
Transcription-coupled nucleosome assembly	62
Using graphs and charts in scientific figures	60
Subconductance states add complexity to Piezo1 gating model	59
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	59
Microtubule nucleation for spindle assembly: one molecule at a time	59
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	58
Glucokinase: from allosteric glucose sensing to disease variants	57
The transition phase: preparing to launch a laboratory	56
Proteasome-derived peptides: separating the trash from the recycling	56
Exploring membrane asymmetry and its effects on membrane proteins	53
Diverse heterochromatin states restricting cell identity and reprogramming	51
Creative approaches using proximity labeling to gain new biological insights	50
Structural parasitology of the malaria parasite Plasmodium falciparum	49
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	48
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	48
Cell entry by SARS-CoV-2	47
Apart, together	46
Activation, decommissioning, and dememorization: enhancers in a life cycle	46
Advisory Board and Contents	46
Making ends meet: a universal driver of large ribosomal subunit biogenesis	45
Subscription and Copyright Information	45
Engineering RiPP pathways: strategies for generating complex bioactive peptides	44
Making nucleic acid structures and schematics	42
Two hearts beat as one: the debate over RAS dimers continues	41
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	41
The metabolic code of ferroptosis: nutritional regulators of cell death	41
An outreach activity to enhance biochemistry pedagogy	40
A plant immune protein fights against cancer	39
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	38
Thiol dioxygenases: from structures to functions	38
Innovations in the electron transport chain fuel archaeal methane metabolism	37
Seeing the forest through the trees: characterizing the glycoproteome	36
Just bypass it: mechanisms of DNA damage tolerance	36
Mitochondrial compartmentalization: emerging themes in structure and function	35
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	35
Functional modulation of chemical mediators in microbial communities	35
The expanding landscape of canonical and non-canonical protein phosphorylation	35
The RNA tether model for human chromosomal translocation fragile zones	35
Subscription and Copyright Information	34
Subscription and Copyright Information	34
Control of chloroplast degradation and cell death in response to stress	34
Metamorphic protein folding as evolutionary adaptation	33
Cloud computing platforms to support cryo-EM structure determination	33
Liquid–liquid phase separation in presynaptic nerve terminals	32
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	31
Origins and evolving functionalities of tRNA-derived small RNAs	30
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	30
Non-histone binding functions of PHD fingers	30
Convergent evolution in two bacterial replicative helicase loaders	30

Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	30
Advisory Board and Contents	30
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	30
Advisory Board and Contents	29
Orange carotenoid proteins: structural understanding of evolution and function	29
The crosstalk of m6A-modified RNA with DNA damage repair	29
Programmable protein editing	29
CryoEM shows the active dynein complex on microtubules	29
Proteostasis in cellular dormancy: lessons from yeast to oocytes	27
Recent advances in enzymes active on lignin-derived aromatic compounds	27
Forging a path toward a more sustainable laboratory	27
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	27
Does chromatin function as a metabolite reservoir?	26
Time-resolved serial crystallography to reveal protein structural changes	26
Multifaceted control of T cell differentiation by STIM1	26
Lamin post-translational modifications: emerging toggles of nuclear organization and function	25
Circular RNAs in physiology and non-immunological diseases	25
Cooperative assembly of the mitochondrial respiratory chain	25
Advances, challenges, and opportunities in structural biology	25
Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	24
Subscription and Copyright Information	24
E3 ubiquitin ligases in signaling, disease, and therapeutics	24
Lysines and cysteines: partners in stress?	24
Computationally guided AAV engineering for enhanced gene delivery	23
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	23
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	23
TRAPs: the ‘elevator-with-an-operator’ mechanism	23
Subscription and Copyright Information	23
Monitoring subcellular NADP redox state with NAPstar biosensors	23
Advancing nanopore technology toward protein identification and sequencing	23
Wrapping up a special series on scientific figure development	23
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	22
How to compile different types of structural visualizations in one panel	22
How integrin phosphorylations regulate cell adhesion and signaling	22
FN3K: the (un)sweetest kinase	22
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	22
Endogenous plant nitroxyl, a new component of nitric oxide biology	21
Discordant skeletal muscle gene and protein responses to exercise	21
Protein SUMOylation and phase separation: partners in stress?	21
SRC homology 3 domains: multifaceted binding modules	20
Synaptoneurolipidomics: lipidomics in the study of synaptic function	20
Lipidation status of single membrane-associated ATG8 proteins	20
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	20
Discovering riboswitches: the past and the future	20
To Ub or not to Ub: a regulatory question in TGF-β signaling	20
Exploring nondegrading molecular glues for protein–protein interactions	19
Oxytocin and vasopressin signaling in health and disease	19
Subscription and Copyright Information	19
Structural transitions modulate the chaperone activities of Grp94	19
Advisory Board and Contents	18
Enlightening epigenetics: optochemical tools illuminate the path	18
Maximizing grant funding: strategies for negotiating laboratory pricing	18
Protein Termini 2022: central roles of protein ends	18
Uncovering viral RNA–host cell interactions on a proteome-wide scale	18
Creating accessibility in academic negotiations	18
Understanding the dynamic design of the spliceosome	18
Spray-type modifications: an emerging paradigm in post-translational modifications	17
Cytoplasmic gene expression: lessons from poxviruses	17
Mitochondrial DNA: cellular genotoxic stress sentinel	17
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	17
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	17
Subscription and Copyright Information	16
Structural advances in sterol-sensing domain-containing proteins	16
Advisory Board and Contents	16
Biomolecules capturing live bacteria from clinical samples	16
Advisory Board and Contents	16
Advisory Board and Contents	16
Film-like organelles equip cells with multiple genetic codes	16
A vigilant gliding bird protects plants	16
Subscription and Copyright Information	16
Thermal proteome profiling of protein-centric interactions and modifications	15
Using light to drive energy transduction in metazoan aging	15
News about amino acid metabolism in plant–microbe interactions	15
Coupling lipid synthesis with nuclear envelope remodeling	15
The lysosome as a master regulator of iron metabolism	15
Substrate and phosphorylation site selection by phosphoprotein phosphatases	15
Transforming eukaryotic cell culture with macromolecular crowding	15
Mitochondria in disease: changes in shapes and dynamics	15