OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Advisory Board and Contents	515
Subscription and Copyright Information	249
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	217
Conserved signaling gears that sustain circadian clock robustness	140
Subscription and Copyright Information	140
Advisory Board and Contents	139
Harnessing the power of peptides: advances and collaborations in biochemistry	135
Adding post-translational modifications and protein–protein interactions to protein schematics	133
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	122
Did circular DNA shape the evolution of mammalian genomes?	117
Novel machine learning approaches revolutionize protein knowledge	111
Understanding peptide hormones: from precursor proteins to bioactive molecules	105
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	104
Multiplayer virtual reality for understanding biomolecular structures	99
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	86
Parallels and crosstalk of ADP-ribosylation and ubiquitination	85
Decoding ceramide function: how localization shapes cellular fate and how to study it	79
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	76
Cellular oxidants and the proteostasis network: balance between activation and destruction	76
From lead to market: chemical approaches to transform peptides into therapeutics	72
Subconductance states add complexity to Piezo1 gating model	70
Microtubule nucleation for spindle assembly: one molecule at a time	69
Proteasome-derived peptides: separating the trash from the recycling	67
Challenges of biomolecular science education in Africa and the way forward	66
Bacterial transformation	66

Using graphs and charts in scientific figures	63
The transition phase: preparing to launch a laboratory	63
Transcription-coupled global genomic repair in E. coli	61
Exploring membrane asymmetry and its effects on membrane proteins	61
Mobile peptide and receptor complex mediates systemic stomatal immunity	59
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	57
Determining and interpreting protein lifetimes in mammalian tissues	55
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	55
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	55
Glucokinase: from allosteric glucose sensing to disease variants	55
Activation, decommissioning, and dememorization: enhancers in a life cycle	53
Diverse heterochromatin states restricting cell identity and reprogramming	52
Transcription-coupled nucleosome assembly	52
Autophagy regulation by phase separation, avidity, and wetting	51
Mitochondrial dynamics and pore formation in regulated cell death pathways	51
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	51
Creative approaches using proximity labeling to gain new biological insights	50
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	49
Orthogonal regulation of protein abundance	46
Subscription and Copyright Information	45
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	44
Making ends meet: a universal driver of large ribosomal subunit biogenesis	44
Seeing the forest through the trees: characterizing the glycoproteome	44
An outreach activity to enhance biochemistry pedagogy	43
Thiol dioxygenases: from structures to functions	43
A plant immune protein fights against cancer	42
Making nucleic acid structures and schematics	42
Advisory Board and Contents	41
Just bypass it: mechanisms of DNA damage tolerance	39
Engineering RiPP pathways: strategies for generating complex bioactive peptides	39
The RNA tether model for human chromosomal translocation fragile zones	38
The metabolic code of ferroptosis: nutritional regulators of cell death	38
Control of chloroplast degradation and cell death in response to stress	37
Adenosine signals an imbalance between activity and supply in privileged cells	37
Functional modulation of chemical mediators in microbial communities	37
Innovations in the electron transport chain fuel archaeal methane metabolism	36
Tandem repeats matter for the functional versatility of giant proteins	36
Pyruvylation: a link bridging metabolic disorders and impaired antiviral immunity	36
Two hearts beat as one: the debate over RAS dimers continues	35
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	35
The expanding landscape of canonical and non-canonical protein phosphorylation	34
Subscription and Copyright Information	34
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	34
Decoding disease-relevant variants with base and prime editors at scale	33
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	33
Convergent evolution in two bacterial replicative helicase loaders	33
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	33
Non-histone binding functions of PHD fingers	33
Subscription and Copyright Information	33
Subscription and Copyright Information	33

Subscription and Copyright Information	33
Liquid–liquid phase separation in presynaptic nerve terminals	32
Zn2+ transients and signaling in mammalian systems	32
Metamorphic protein folding as evolutionary adaptation	32
TiBS at 50	31
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	31
Advisory Board and Contents	31
Advisory Board and Contents	31
CryoEM shows the active dynein complex on microtubules	30
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	30
Time-resolved serial crystallography to reveal protein structural changes	29
Orange carotenoid proteins: structural understanding of evolution and function	29
The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine	29
Recent advances in enzymes active on lignin-derived aromatic compounds	29
Programmable protein editing	29
Functional insights into the nitrogenase-like enzyme superfamily	29
Proteostasis in cellular dormancy: lessons from yeast to oocytes	28
Does chromatin function as a metabolite reservoir?	27
Forging a path toward a more sustainable laboratory	27
Cooperative assembly of the mitochondrial respiratory chain	27
Multifaceted control of T cell differentiation by STIM1	27
The crosstalk of m6A-modified RNA with DNA damage repair	26
Advisory Board and Contents	25
Advances, challenges, and opportunities in structural biology	25
Subscription and Copyright Information	25
Computationally guided AAV engineering for enhanced gene delivery	25
TRAPs: the ‘elevator-with-an-operator’ mechanism	24
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	24
Monitoring subcellular NADP redox state with NAPstar biosensors	24
E3 ubiquitin ligases in signaling, disease, and therapeutics	24
Advancing nanopore technology toward protein identification and sequencing	24
Advances in understanding aryl hydrocarbon receptor structure, function, and modulation	24
Powerful polymerases synthesize labeled RNA better, faster, stronger	24
How to compile different types of structural visualizations in one panel	23
Advisory Board and Contents	23
Subscription and Copyright Information	23
Discordant skeletal muscle gene and protein responses to exercise	23
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	23
FN3K: the (un)sweetest kinase	23
Wrapping up a special series on scientific figure development	23
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	23
Oxytocin and vasopressin signaling in health and disease	22
Synaptoneurolipidomics: lipidomics in the study of synaptic function	22
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	22
Protein SUMOylation and phase separation: partners in stress?	22
To Ub or not to Ub: a regulatory question in TGF-β signaling	22
Endogenous plant nitroxyl, a new component of nitric oxide biology	22
SRC homology 3 domains: multifaceted binding modules	22
Discovering riboswitches: the past and the future	21
Enlightening epigenetics: optochemical tools illuminate the path	21
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	21
Advisory Board and Contents	21
Protein Termini 2022: central roles of protein ends	20
Structural transitions modulate the chaperone activities of Grp94	20
Subscription and Copyright Information	20
Creating accessibility in academic negotiations	20
Maximizing grant funding: strategies for negotiating laboratory pricing	20
Emerging roles and regulatory mechanisms involved in glutamine metabolism	19
The past, present, and future of RNA biochemistry and mitochondrial research	19
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	19
Voices across Africa: from local challenges to global impact	19
Cytoplasmic gene expression: lessons from poxviruses	19
Spray-type modifications: an emerging paradigm in post-translational modifications	19
Mass spectrometry-based single-cell proteomics technologies, trends, and biological insights	19
Understanding the dynamic design of the spliceosome	18
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	18
Emerging structural insights into PRC2 function in development and disease	18
Regulation of plant NLRs by post-translational modifications	18
Exploring nondegrading molecular glues for protein–protein interactions	18
Biomolecules capturing live bacteria from clinical samples	17
Subscription and Copyright Information	17
Advisory Board and Contents	16
A vigilant gliding bird protects plants	16
Adenosylhomocysteinase–adenosine complex links m6A and cancer lipid metabolism	16
Advisory Board and Contents	16
Thermal proteome profiling of protein-centric interactions and modifications	16
Using light to drive energy transduction in metazoan aging	16
Subscription and Copyright Information	16
Cytosolic AcCoA: a metabolic signal bridging nutrient sensing and mitophagy	16