OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Subscription and Copyright Information	260
Subscription and Copyright Information	219
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	156
Adding post-translational modifications and protein–protein interactions to protein schematics	144
Subscription and Copyright Information	144
Advisory Board and Contents	139
From lead to market: chemical approaches to transform peptides into therapeutics	135
Multiplayer virtual reality for understanding biomolecular structures	132
Advisory Board and Contents	121
Decoding ceramide function: how localization shapes cellular fate and how to study it	113
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	107
Novel machine learning approaches revolutionize protein knowledge	96
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	96
Did circular DNA shape the evolution of mammalian genomes?	90
Understanding peptide hormones: from precursor proteins to bioactive molecules	88
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	86
Cellular oxidants and the proteostasis network: balance between activation and destruction	86
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	85
Molecular mechanisms of heat shock factor 1 regulation	85
Transporter Specificity: A Tale of Loosened Elevator-Sliding	83
Exploiting enzyme evolution for computational protein design	81
Subscription and Copyright Information	79
The transition phase: preparing to launch a laboratory	77
Determining and interpreting protein lifetimes in mammalian tissues	74
Glucokinase: from allosteric glucose sensing to disease variants	74

Activation, decommissioning, and dememorization: enhancers in a life cycle	73
Transcription-coupled global genomic repair in E. coli	70
Diverse heterochromatin states restricting cell identity and reprogramming	69
Subconductance states add complexity to Piezo1 gating model	67
Microtubule nucleation for spindle assembly: one molecule at a time	66
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	66
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	66
Exploring membrane asymmetry and its effects on membrane proteins	65
Transcription-coupled nucleosome assembly	64
Using graphs and charts in scientific figures	62
Structural parasitology of the malaria parasite Plasmodium falciparum	62
Cell entry by SARS-CoV-2	59
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	57
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	55
Creative approaches using proximity labeling to gain new biological insights	55
FUS and TDP-43 Phases in Health and Disease	54
Apart, together	54
Advisory Board and Contents	52
Innovations in the electron transport chain fuel archaeal methane metabolism	51
Seeing the forest through the trees: characterizing the glycoproteome	50
The expanding landscape of canonical and non-canonical protein phosphorylation	49
Control of chloroplast degradation and cell death in response to stress	49
Mitochondrial compartmentalization: emerging themes in structure and function	48
Making nucleic acid structures and schematics	46
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	46
Making ends meet: a universal driver of large ribosomal subunit biogenesis	46
A plant immune protein fights against cancer	44
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	44
The RNA tether model for human chromosomal translocation fragile zones	43
Thiol dioxygenases: from structures to functions	42
Two hearts beat as one: the debate over RAS dimers continues	42
Functional modulation of chemical mediators in microbial communities	41
An outreach activity to enhance biochemistry pedagogy	41
Direct Structural Insights into GABAA Receptor Pharmacology	41
Subscription and Copyright Information	41
Subscription and Copyright Information	40
Cloud computing platforms to support cryo-EM structure determination	40
Non-histone binding functions of PHD fingers	40
Metamorphic protein folding as evolutionary adaptation	39
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	39
Convergent evolution in two bacterial replicative helicase loaders	39
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	38
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	38
Liquid–liquid phase separation in presynaptic nerve terminals	36
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	36
Origins and evolving functionalities of tRNA-derived small RNAs	36
Multifaceted control of T cell differentiation by STIM1	35
Advisory Board and Contents	35
Does chromatin function as a metabolite reservoir?	35
Subscription and Copyright Information	35

Time-resolved serial crystallography to reveal protein structural changes	34
Cooperative assembly of the mitochondrial respiratory chain	34
CryoEM shows the active dynein complex on microtubules	34
Orange carotenoid proteins: structural understanding of evolution and function	31
Recent advances in enzymes active on lignin-derived aromatic compounds	31
Advisory Board and Contents	31
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	31
Forging a path toward a more sustainable laboratory	31
Circular RNAs in physiology and non-immunological diseases	30
Lamin post-translational modifications: emerging toggles of nuclear organization and function	28
Advances, challenges, and opportunities in structural biology	28
TRAPs: the ‘elevator-with-an-operator’ mechanism	27
Computationally guided AAV engineering for enhanced gene delivery	26
Monitoring subcellular NADP redox state with NAPstar biosensors	26
Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	26
Subscription and Copyright Information	25
How to compile different types of structural visualizations in one panel	25
Lysines and cysteines: partners in stress?	25
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	25
Wrapping up a special series on scientific figure development	25
How integrin phosphorylations regulate cell adhesion and signaling	24
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	24
FN3K: the (un)sweetest kinase	24
Lipidation status of single membrane-associated ATG8 proteins	24
SRC homology 3 domains: multifaceted binding modules	24
Protein SUMOylation and phase separation: partners in stress?	24
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	23
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	23
Oxytocin and vasopressin signaling in health and disease	22
Synaptoneurolipidomics: lipidomics in the study of synaptic function	22
Endogenous plant nitroxyl, a new component of nitric oxide biology	22
Discovering riboswitches: the past and the future	22
To Ub or not to Ub: a regulatory question in TGF-β signaling	22
Subscription and Copyright Information	21
Advisory Board and Contents	21
Discordant skeletal muscle gene and protein responses to exercise	21
Protein Termini 2022: central roles of protein ends	21
Creating accessibility in academic negotiations	21
Enlightening epigenetics: optochemical tools illuminate the path	20
Uncovering viral RNA–host cell interactions on a proteome-wide scale	20
Maximizing grant funding: strategies for negotiating laboratory pricing	20
Understanding the dynamic design of the spliceosome	20
Spray-type modifications: an emerging paradigm in post-translational modifications	20
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	20
Cytoplasmic gene expression: lessons from poxviruses	20
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	20
Biomolecules capturing live bacteria from clinical samples	20
Regulation of Autophagy Enzymes by Nutrient Signaling	20
Structural transitions modulate the chaperone activities of Grp94	20
Subscription and Copyright Information	19
Advisory Board and Contents	19
Mitochondrial DNA: cellular genotoxic stress sentinel	19
More Than Just Closed and Open: Unraveling a Mechanosensor	19
Using light to drive energy transduction in metazoan aging	19
Advisory Board and Contents	18
Film-like organelles equip cells with multiple genetic codes	18
Advisory Board and Contents	18
Coupling lipid synthesis with nuclear envelope remodeling	18
A vigilant gliding bird protects plants	18
Take Your PIC	18
Thermal proteome profiling of protein-centric interactions and modifications	17
Subscription and Copyright Information	17
Substrate and phosphorylation site selection by phosphoprotein phosphatases	17
News about amino acid metabolism in plant–microbe interactions	17
Transforming eukaryotic cell culture with macromolecular crowding	17
Structural advances in sterol-sensing domain-containing proteins	17
The lysosome as a master regulator of iron metabolism	16
Subscription and Copyright Information	16
Subscription and Copyright Information	16
Subscription and Copyright Information	16
Advisory Board and Contents	16
Mitochondria in disease: changes in shapes and dynamics	16
Advisory Board and Contents	16