Trends in Biochemical Sciences

(The TQCC of Trends in Biochemical Sciences is 60. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
The AMP-activated protein kinase cascade – a unifying system for energy control879
TPR proteins: the versatile helix851
The riboswitch control of bacterial metabolism435
Rheb fills a GAP between TSC and TOR365
Distinct monoubiquitin signals in receptor endocytosis331
SUMO: ligases, isopeptidases and nuclear pores311
TSC2: filling the GAP in the mTOR signaling pathway299
NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?293
Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches227
SAM domains: uniform structure, diversity of function211
The intracellular voyage of cholera toxin: going retro208
Functional regulation of p73 and p63: development and cancer208
Lactate: A Metabolic Driver in the Tumour Landscape179
The Claudins: From Tight Junctions to Biological Systems178
Cryo-Electron Microscopy Methodology: Current Aspects and Future Directions140
Interconnection between Metabolism and Cell Cycle in Cancer134
Historical review: Another 50th anniversary – new periodicities in coiled coils121
Sharing the SAGA118
Biophysical and Mechanistic Models for Disease-Causing Protein Variants116
The small Tim proteins and the twin Cx3C motif110
Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy110
The Structural Basis of Necroptotic Cell Death Signaling107
Targeting Metabolic–Redox Circuits for Cancer Therapy96
Altered function and regulation of cardiac ryanodine receptors in cardiac disease95
New Binding Sites, New Opportunities for GPCR Drug Discovery91
Nanoarchitecture Frameworks for Electrochemical miRNA Detection91
Historical review: Deciphering the genetic code – a personal account82
Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control81
Lysosomal Ion Channels as Decoders of Cellular Signals78
Impact of disease-related mitochondrial mutations on tRNA structure and function77
The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants77
Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites76
Nutrient Zinc at the Host–Pathogen Interface72
The Tumor Suppressor PALB2: Inside Out72
Nature and Regulation of Protein Folding on the Ribosome71
Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation71
Function and Evolution of Upstream ORFs in Eukaryotes68
Bringing Molecular Dynamics Simulation Data into View64
Emerging Structural Understanding of Amyloid Fibrils by Solid-State NMR61
Engineering Metalloprotein Functions in Designed and Native Scaffolds61
Diseases of protein conformation: what do in vitro experiments tell us about in vivo diseases?60
Ribosome Stoichiometry: From Form to Function60