Trends in Biochemical Sciences

Papers
(The TQCC of Trends in Biochemical Sciences is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Biomolecular Condensates in the Nucleus243
Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy211
The SLC25 Mitochondrial Carrier Family: Structure and Mechanism180
Mechanisms and Functions of Chromosome Compartmentalization149
FUS and TDP-43 Phases in Health and Disease144
Mechanisms and Regulation of RNA Condensation in RNP Granule Formation129
Reciprocal Regulation of Mitochondrial Fission and Fusion120
Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases113
Cell entry by SARS-CoV-2111
Structure and Roles of V-type ATPases110
Hippo Signaling in Embryogenesis and Development109
Autophagy Assays for Biological Discovery and Therapeutic Development95
Single-Cell Proteomics90
G-Quadruplexes in RNA Biology: Recent Advances and Future Directions87
Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis81
YAP and TAZ Are Not Identical Twins79
How Lysosomes Sense, Integrate, and Cope with Stress78
The Cytoskeleton as Regulator of Cell Signaling Pathways76
Cytosolic Events in the Biogenesis of Mitochondrial Proteins75
Origins and evolving functionalities of tRNA-derived small RNAs73
Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells73
Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels72
Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria68
Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity68
To Eat or to Die: Deciphering Selective Forms of Autophagy67
The lysosome as a master regulator of iron metabolism65
Extracellular miRNAs and Cell–Cell Communication: Problems and Prospects65
Functional Diversification of ER Stress Responses in Arabidopsis64
Beyond Autophagy: The Expanding Roles of ATG8 Proteins63
ADAR RNA Modifications, the Epitranscriptome and Innate Immunity62
Myristoylation, an Ancient Protein Modification Mirroring Eukaryogenesis and Evolution62
Mechanisms of Long Noncoding RNA Nuclear Retention62
One Ring to Rule them All? Structural and Functional Diversity in the Nuclear Pore Complex62
Coordinating gene expression during the cell cycle62
Circular RNAs in Immune Response and Viral Infection60
ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease59
The Golgi as an Assembly Line to the Autophagosome58
Coupling of Ribosome Synthesis and Translational Capacity with Cell Growth58
Nothing Is Yet Set in (Hi)stone: Novel Post-Translational Modifications Regulating Chromatin Function58
Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo57
Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling57
Histone Lactylation: A New Role for Glucose Metabolism57
Emerging Insights into the Structure and Function of Complement C5a Receptors55
Histone Tail Conformations: A Fuzzy Affair with DNA53
The NLRP3 inflammasome: activation and regulation53
A Chain of Events: Regulating Target Proteins by SUMO Polymers53
Discovering riboswitches: the past and the future52
Activation and Regulation of Cytoplasmic Dynein51
Metabolism and the Epigenome: A Dynamic Relationship51
Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function51
Direct Structural Insights into GABAA Receptor Pharmacology51
Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis50
Phytochemicals as Prebiotics and Biological Stress Inducers50
Biomolecular Condensates and Their Links to Cancer Progression50
Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications50
Mitochondrial DNA: cellular genotoxic stress sentinel47
Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation46
Rapid Detection and Signaling of DNA Damage by PARP-146
Translational control through ribosome heterogeneity and functional specialization43
Regulation of Autophagy Enzymes by Nutrient Signaling43
The Retromer Complex: From Genesis to Revelations43
Molecular Determinants of Flavivirus Virion Assembly42
Chaperone Machineries of Rubisco – The Most Abundant Enzyme42
How Cells Respond to DNA Breaks in Mitosis42
A Tour of TOR Complex Signaling in Plants42
How do plants feel the heat and survive?41
Genetically Encodable Fluorescent and Bioluminescent Biosensors Light Up Signaling Networks41
Revisiting Extracellular RNA Release, Processing, and Function41
A Unifying Mechanism of DNA Translocation Underlying Chromatin Remodeling41
Drug discovery in the era of cryo-electron microscopy40
The Wide World of Coacervates: From the Sea to Neurodegeneration39
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective39
The Hammer and the Dance of Cell Cycle Control39
Molecular mechanisms of heat shock factor 1 regulation39
Spirits in the Material World: Enhancer RNAs in Transcriptional Regulation37
Divalent Cations: A Molecular Glue for Protein Materials37
Miniproteins as a Powerful Modality in Drug Development36
Integrins Control Vesicular Trafficking; New Tricks for Old Dogs36
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?35
The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis35
The Integrator Complex in Transcription and Development35
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting35
The Evolution of STING Signaling and Its Involvement in Cancer35
Big-Data Glycomics: Tools to Connect Glycan Biosynthesis to Extracellular Communication34
Gene-Specific Actions of Transcriptional Coregulators Facilitate Physiological Plasticity: Evidence for a Physiological Coregulator Code34
Nonredundant Roles of GRASP55 and GRASP65 in the Golgi Apparatus and Beyond34
Detecting and Rescuing Stalled Ribosomes34
DEAH-Box RNA Helicases in Pre-mRNA Splicing33
Mimicry of Short Linear Motifs by Bacterial Pathogens: A Drugging Opportunity33
Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks33
Canary in a coal mine: collided ribosomes as sensors of cellular conditions33
Emerging Roles of tRNAs in RNA Virus Infections33
Assembly and function of branched ubiquitin chains33
Nucleic Acid-Based Technologies Targeting Coronaviruses33
Global Approaches in Studying RNA-Binding Protein Interaction Networks32
N-Terminal Proteoforms in Human Disease32
Art and Science of the Cellular Mesoscale32
How Hierarchical Interactions Make Membraneless Organelles Tick Like Clockwork32
Charting a DNA Repair Roadmap for Immunoglobulin Class Switch Recombination31
Structural basis of torque generation in the bi-directional bacterial flagellar motor31
Control of chloroplast degradation and cell death in response to stress31
Mitochondrial compartmentalization: emerging themes in structure and function31
Mentoring during Uncertain Times30
Complementarity of Hydrogen/Deuterium Exchange Mass Spectrometry and Cryo-Electron Microscopy30
Striking Diversity of Mitochondria-Specific Translation Processes across Eukaryotes30
Circular RNAs in physiology and non-immunological diseases29
A roadmap for rRNA folding and assembly during transcription29
Molecular Mobility-Mediated Regulation of E-Cadherin Adhesion29
News about amino acid metabolism in plant–microbe interactions28
Galvanization of Protein–Protein Interactions in a Dynamic Zinc Interactome28
Emerging Features of Linear Motif-Binding Hub Proteins27
Advances in the World of Bacterial Microcompartments27
Limiting the DNA Double-Strand Break Resectosome for Genome Protection27
Therapeutic targeting of TEAD transcription factors in cancer26
The Life Cycle of the Mu-Opioid Receptor26
Methods to Study Phase-Separated Condensates and the Underlying Molecular Interactions26
Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling26
N6-Methyladenosine Regulates Host Responses to Viral Infection25
The Autophagy–RNA Interplay: Degradation and Beyond25
Plant biochemistry influences tropospheric ozone formation, destruction, deposition, and response24
The many faces of RNA-based RNase P, an RNA-world relic24
Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues24
Time to target the circadian clock for drug discovery23
The Mediator kinase module: an interface between cell signaling and transcription23
Non-enzymatic Covalent Modifications as a New Chapter in the Histone Code22
MicroRNA turnover: a tale of tailing, trimming, and targets22
How integrin phosphorylations regulate cell adhesion and signaling22
COVID-19 Vaccines Based on Adenovirus Vectors22
The broader sense of nonsense22
Molecular Mechanisms of Lysosome and Nucleus Communication22
Nucleosomes Meet Their Remodeler Match22
Coupling lipid synthesis with nuclear envelope remodeling22
Creating memories: molecular mechanisms of CRISPR adaptation21
A Tale of Two Moieties: Rapidly Evolving CRISPR/Cas-Based Genome Editing21
Are Parallel Proliferation Pathways Redundant?21
Novel machine learning approaches revolutionize protein knowledge21
Transforming eukaryotic cell culture with macromolecular crowding21
Plasmon-Driven Ultrafast Photonic PCR20
Completing the canvas: advances and challenges for DNA-PAINT super-resolution imaging20
PI3K functions as a hub in mechanotransduction20
Linker Domains: Why ABC Transporters ‘Live in Fragments no Longer’20
Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines20
Ribosomal DNA and the nucleolus at the heart of aging20
DNA Processing in the Context of Noncoding Transcription20
0.028301000595093