OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Subscription and Copyright Information	338
Subscription and Copyright Information	195
Subscription and Copyright Information	166
Adding post-translational modifications and protein–protein interactions to protein schematics	157
Advisory Board and Contents	152
Multiplayer virtual reality for understanding biomolecular structures	147
Understanding peptide hormones: from precursor proteins to bioactive molecules	115
Harnessing the power of peptides: advances and collaborations in biochemistry	101
Advisory Board and Contents	100
Transporter Specificity: A Tale of Loosened Elevator-Sliding	95
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	94
Novel machine learning approaches revolutionize protein knowledge	93
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	91
Conserved signaling gears that sustain circadian clock robustness	88
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	82
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	78
Exploiting enzyme evolution for computational protein design	78
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	78
Did circular DNA shape the evolution of mammalian genomes?	73
Cellular oxidants and the proteostasis network: balance between activation and destruction	72
Decoding ceramide function: how localization shapes cellular fate and how to study it	72
Molecular mechanisms of heat shock factor 1 regulation	72
From lead to market: chemical approaches to transform peptides into therapeutics	70
Determining and interpreting protein lifetimes in mammalian tissues	69
Transcription-coupled global genomic repair in E. coli	67

Creative approaches using proximity labeling to gain new biological insights	62
Cell entry by SARS-CoV-2	61
Structural parasitology of the malaria parasite Plasmodium falciparum	61
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	60
Activation, decommissioning, and dememorization: enhancers in a life cycle	59
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	57
Diverse heterochromatin states restricting cell identity and reprogramming	57
Using graphs and charts in scientific figures	57
Subconductance states add complexity to Piezo1 gating model	56
Glucokinase: from allosteric glucose sensing to disease variants	55
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	55
Microtubule nucleation for spindle assembly: one molecule at a time	54
Proteasome-derived peptides: separating the trash from the recycling	53
Transcription-coupled nucleosome assembly	51
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	50
The transition phase: preparing to launch a laboratory	48
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	47
Apart, together	47
Exploring membrane asymmetry and its effects on membrane proteins	47
Engineering RiPP pathways: strategies for generating complex bioactive peptides	46
Advisory Board and Contents	46
Subscription and Copyright Information	45
The RNA tether model for human chromosomal translocation fragile zones	44
Functional modulation of chemical mediators in microbial communities	43
Making nucleic acid structures and schematics	43
Two hearts beat as one: the debate over RAS dimers continues	42
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	40
An outreach activity to enhance biochemistry pedagogy	40
A plant immune protein fights against cancer	40
Thiol dioxygenases: from structures to functions	39
Innovations in the electron transport chain fuel archaeal methane metabolism	39
Mitochondrial compartmentalization: emerging themes in structure and function	38
Seeing the forest through the trees: characterizing the glycoproteome	37
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	37
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	37
The expanding landscape of canonical and non-canonical protein phosphorylation	35
Control of chloroplast degradation and cell death in response to stress	35
Just bypass it: mechanisms of DNA damage tolerance	35
The metabolic code of ferroptosis: nutritional regulators of cell death	34
Making ends meet: a universal driver of large ribosomal subunit biogenesis	34
Subscription and Copyright Information	33
Convergent evolution in two bacterial replicative helicase loaders	33
Subscription and Copyright Information	33
Cloud computing platforms to support cryo-EM structure determination	33
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	32
Liquid–liquid phase separation in presynaptic nerve terminals	32
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	32
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	31
Non-histone binding functions of PHD fingers	31
Metamorphic protein folding as evolutionary adaptation	30

Origins and evolving functionalities of tRNA-derived small RNAs	29
Recent advances in enzymes active on lignin-derived aromatic compounds	28
Advisory Board and Contents	28
Advisory Board and Contents	28
Proteostasis in cellular dormancy: lessons from yeast to oocytes	28
Does chromatin function as a metabolite reservoir?	28
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	28
Programmable protein editing	28
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
Forging a path toward a more sustainable laboratory	27
Time-resolved serial crystallography to reveal protein structural changes	27
Lamin post-translational modifications: emerging toggles of nuclear organization and function	27
Orange carotenoid proteins: structural understanding of evolution and function	26
Circular RNAs in physiology and non-immunological diseases	26
Multifaceted control of T cell differentiation by STIM1	26
The crosstalk of m6A-modified RNA with DNA damage repair	26
CryoEM shows the active dynein complex on microtubules	26
Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	25
Advances, challenges, and opportunities in structural biology	25
Cooperative assembly of the mitochondrial respiratory chain	25
Lysines and cysteines: partners in stress?	25
Computationally guided AAV engineering for enhanced gene delivery	24
Subscription and Copyright Information	24
Monitoring subcellular NADP redox state with NAPstar biosensors	23
Subscription and Copyright Information	23
How to compile different types of structural visualizations in one panel	23
TRAPs: the ‘elevator-with-an-operator’ mechanism	23
FN3K: the (un)sweetest kinase	23
Endogenous plant nitroxyl, a new component of nitric oxide biology	23
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	23
Advancing nanopore technology toward protein identification and sequencing	23
Lipidation status of single membrane-associated ATG8 proteins	23
Wrapping up a special series on scientific figure development	23
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	22
Oxytocin and vasopressin signaling in health and disease	22
Protein SUMOylation and phase separation: partners in stress?	21
SRC homology 3 domains: multifaceted binding modules	21
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	21
How integrin phosphorylations regulate cell adhesion and signaling	20
Synaptoneurolipidomics: lipidomics in the study of synaptic function	20
Discordant skeletal muscle gene and protein responses to exercise	20
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	20
To Ub or not to Ub: a regulatory question in TGF-β signaling	20
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	20
Discovering riboswitches: the past and the future	20
Subscription and Copyright Information	19
Advisory Board and Contents	18
Understanding the dynamic design of the spliceosome	18
Mitochondrial DNA: cellular genotoxic stress sentinel	18
Enlightening epigenetics: optochemical tools illuminate the path	18
Protein Termini 2022: central roles of protein ends	18
Cytoplasmic gene expression: lessons from poxviruses	18
Maximizing grant funding: strategies for negotiating laboratory pricing	18
Biomolecules capturing live bacteria from clinical samples	18
Spray-type modifications: an emerging paradigm in post-translational modifications	18
Take Your PIC	17
Structural transitions modulate the chaperone activities of Grp94	17
Exploring nondegrading molecular glues for protein–protein interactions	17
Advisory Board and Contents	17
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	17
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	17
Subscription and Copyright Information	17
Creating accessibility in academic negotiations	17
Uncovering viral RNA–host cell interactions on a proteome-wide scale	17
Film-like organelles equip cells with multiple genetic codes	16
Transforming eukaryotic cell culture with macromolecular crowding	16
A vigilant gliding bird protects plants	16
Subscription and Copyright Information	16
Advisory Board and Contents	16
Advisory Board and Contents	16
Using light to drive energy transduction in metazoan aging	15
Structural advances in sterol-sensing domain-containing proteins	15
Substrate and phosphorylation site selection by phosphoprotein phosphatases	15
Thermal proteome profiling of protein-centric interactions and modifications	15
Coupling lipid synthesis with nuclear envelope remodeling	15