Trends in Biochemical Sciences

Article	Citations
Advisory Board and Contents	560
Subscription and Copyright Information	259
Subscription and Copyright Information	225
Conserved signaling gears that sustain circadian clock robustness	157
Advisory Board and Contents	152
Adding post-translational modifications and protein–protein interactions to protein schematics	145
Harnessing the power of peptides: advances and collaborations in biochemistry	145
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	144
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	130
Multiplayer virtual reality for understanding biomolecular structures	130
Parallels and crosstalk of ADP-ribosylation and ubiquitination	128
Did circular DNA shape the evolution of mammalian genomes?	115
Strengthening the philosophical basis of graduate science education	107
Cap in hand: giant viruses, stolen translation, and a road to endosymbiosis?	102
Intrinsically disordered regions in eukaryotic mRNA decay pathways	93
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	91
Novel machine learning approaches revolutionize protein knowledge	89
Understanding peptide hormones: from precursor proteins to bioactive molecules	85
Decoding ceramide function: how localization shapes cellular fate and how to study it	82
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	81
From lead to market: chemical approaches to transform peptides into therapeutics	80
Cellular oxidants and the proteostasis network: balance between activation and destruction	80
Subconductance states add complexity to Piezo1 gating model	75
Bacterial transformation	72
Challenges of biomolecular science education in Africa and the way forward	72

Using graphs and charts in scientific figures	71
The transition phase: preparing to launch a laboratory	70
Determining and interpreting protein lifetimes in mammalian tissues	69
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	66
Activation, decommissioning, and dememorization: enhancers in a life cycle	64
Mobile peptide and receptor complex mediates systemic stomatal immunity	60
Transcription-coupled nucleosome assembly	60
Transcription-coupled global genomic repair in E. coli	58
Glucokinase: from allosteric glucose sensing to disease variants	57
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	57
Microtubule nucleation for spindle assembly: one molecule at a time	56
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	55
Exploring membrane asymmetry and its effects on membrane proteins	54
Diverse heterochromatin states restricting cell identity and reprogramming	54
Proteasome-derived peptides: separating the trash from the recycling	53
Mitochondrial dynamics and pore formation in regulated cell death pathways	53
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	52
Orthogonal regulation of protein abundance	51
Biochemistry at scale: Seeing both the forest and the trees	51
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	48
Autophagy regulation by phase separation, avidity, and wetting	48
Creative approaches using proximity labeling to gain new biological insights	47
A metabolon channels nicotine biosynthesis	47
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Pyruvylation: a link bridging metabolic disorders and impaired antiviral immunity	46
Advisory Board and Contents	44
A plant immune protein fights against cancer	43
Engineering RiPP pathways: strategies for generating complex bioactive peptides	43
Thiol dioxygenases: from structures to functions	42
Advisory Board and Contents	42
Making ends meet: a universal driver of large ribosomal subunit biogenesis	42
Making nucleic acid structures and schematics	42
The RNA tether model for human chromosomal translocation fragile zones	42
An outreach activity to enhance biochemistry pedagogy	41
Two hearts beat as one: the debate over RAS dimers continues	40
Tandem repeats matter for the functional versatility of giant proteins	39
Control of chloroplast degradation and cell death in response to stress	39
Adenosine signals an imbalance between activity and supply in privileged cells	39
The metabolic code of ferroptosis: nutritional regulators of cell death	39
Just bypass it: mechanisms of DNA damage tolerance	38
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	37
Functional modulation of chemical mediators in microbial communities	37
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	37
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	36
The expanding landscape of canonical and non-canonical protein phosphorylation	36
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Innovations in the electron transport chain fuel archaeal methane metabolism	36
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Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	35

Rethinking transcription factor dynamics and transcription regulation in eukaryotes	34
Zn2+ transients and signaling in mammalian systems	34
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	34
Metamorphic protein folding as evolutionary adaptation	34
Liquid–liquid phase separation in presynaptic nerve terminals	34
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Decoding disease-relevant variants with base and prime editors at scale	33
Non-histone binding functions of PHD fingers	33
Advisory Board and Contents	32
Advisory Board and Contents	32
TiBS at 50	32
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	31
Multifaceted control of T cell differentiation by STIM1	31
CryoEM shows the active dynein complex on microtubules	30
Orange carotenoid proteins: structural understanding of evolution and function	29
Forging a path toward a more sustainable laboratory	29
Cooperative assembly of the mitochondrial respiratory chain	29
Programmable protein editing	29
Does chromatin function as a metabolite reservoir?	29
The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine	28
Recent advances in enzymes active on lignin-derived aromatic compounds	28
Time-resolved serial crystallography to reveal protein structural changes	28
Functional insights into the nitrogenase-like enzyme superfamily	28
The crosstalk of m6A-modified RNA with DNA damage repair	28
Proteostasis in cellular dormancy: lessons from yeast to oocytes	28
Advisory Board and Contents	27
Subscription and Copyright Information	27
Advances, challenges, and opportunities in structural biology	27
Advisory Board and Contents	26
Powerful polymerases synthesize labeled RNA better, faster, stronger	25
PhD journey	25
Monitoring subcellular NADP redox state with NAPstar biosensors	25
Drugging the proteome via large-scale chemoproteomics	25
Advances in understanding aryl hydrocarbon receptor structure, function, and modulation	25
Advancing nanopore technology toward protein identification and sequencing	24
TRAPs: the ‘elevator-with-an-operator’ mechanism	24
Computationally guided AAV engineering for enhanced gene delivery	24
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	23
FN3K: the (un)sweetest kinase	23
E3 ubiquitin ligases in signaling, disease, and therapeutics	23
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	23
Advisory Board and Contents	23
SRC homology 3 domains: multifaceted binding modules	22
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	22
Wrapping up a special series on scientific figure development	22
Endogenous plant nitroxyl, a new component of nitric oxide biology	22
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How to compile different types of structural visualizations in one panel	22
Protein SUMOylation and phase separation: partners in stress?	22
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	22
Oxytocin and vasopressin signaling in health and disease	21
Voices across Asia and Oceania: Biochemistry across borders	21
Synaptoneurolipidomics: lipidomics in the study of synaptic function	21
Discordant skeletal muscle gene and protein responses to exercise	20
Discovering riboswitches: the past and the future	20
Advisory Board and Contents	20
To Ub or not to Ub: a regulatory question in TGF-β signaling	20
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	20
Spray-type modifications: an emerging paradigm in post-translational modifications	19
Protein Termini 2022: central roles of protein ends	19
Enlightening epigenetics: optochemical tools illuminate the path	19
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	18
Maximizing grant funding: strategies for negotiating laboratory pricing	18
Structural transitions modulate the chaperone activities of Grp94	18
Voices across Africa: from local challenges to global impact	18
Regulation of plant NLRs by post-translational modifications	18
Emerging structural insights into PRC2 function in development and disease	18
Biomolecules capturing live bacteria from clinical samples	18
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The past, present, and future of RNA biochemistry and mitochondrial research	18
Cytoplasmic gene expression: lessons from poxviruses	18
Exploring nondegrading molecular glues for protein–protein interactions	17
Mass spectrometry-based single-cell proteomics technologies, trends, and biological insights	17
Creating accessibility in academic negotiations	17
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Advisory Board and Contents	16
Thermal proteome profiling of protein-centric interactions and modifications	16
Understanding the dynamic design of the spliceosome	16
Emerging roles and regulatory mechanisms involved in glutamine metabolism	16
Advisory Board and Contents	16

Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	16
Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease	16
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Integrated approaches for discovery and functional annotation of proteins of unknown function	15
Cytosolic AcCoA: a metabolic signal bridging nutrient sensing and mitophagy	15
Substrate and phosphorylation site selection by phosphoprotein phosphatases	15
Histone-mediated chromatin organization in prokaryotes and viruses	15
Inspiring discovery through reviews and visualization in biochemistry	15
The role of glycan modifications in health and disease	15
News about amino acid metabolism in plant–microbe interactions	15
A vigilant gliding bird protects plants	15
Using light to drive energy transduction in metazoan aging	15
Adenosylhomocysteinase–adenosine complex links m6A and cancer lipid metabolism	15
Mitochondria in disease: changes in shapes and dynamics	15
Subscription and Copyright Information	14
Subscription and Copyright Information	14
Post-translational modifications as key regulators of proline metabolism	14
The intersection of viral mimicry and nuclear entry	14
Advisory Board and Contents	14
How do plants feel the heat and survive?	14
Advisory Board and Contents	14
Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design	14
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Unlocking the protein code: how our organs age across a lifetime	14
From transcription to export: mRNA’s winding path to the cytoplasm	14
Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells	13
Principles for the design of multispecific proteins	13
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The Integrator–PP2A complex integrates promoter-proximal premature termination with chromatin context and genome maintenance	13
Microtubule specialization by +TIP networks: from mechanisms to functional implications	13
The metabolic cross-talk between cancer and T cells	12
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Unlocking translational machinery for antitubercular drug development	12
Confluence and convergence of Dscam and Pcdh cell-recognition codes	12
Giant variations in giant virus genome packaging	12
LncRNAs: the missing link to senescence nuclear architecture	12
The quest to identify ADP-ribosylation readers: methodological advances	12
The physiological relevance of autophagosome morphogenesis	12
Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier	11
Looking lively: emerging principles of pseudokinase signaling	11
Mechanisms and rationales of SAM homeostasis	11
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions	11
Mining the gut microbiota for defluorination activity	11
Mitochondrial heat production: the elephant in the lab…	11
Systems-level modeling: Capturing the true complexity of disease	11
Important questions and future directions in plant biochemistry	10
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Building a laboratory and networks during the COVID-19 pandemic	10
Assembling the jigsaw puzzle of life	10
Biosensor for monitoring PTEN activity in biological systems	10
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain	10
Ensembles of synthetic polymers mimic biological fluids	10
ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising	10
Biogenesis and engineering of interleukin 12 family cytokines	9
Functional diversity, evolution, and translational potential of isoprenoids in eukaryotic membranes	9
The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases	9
Anti-type VI tactics: bacterial defenses against type VI secretion system attacks	9
Back on the chain gang: polyphosphate modification of proteins	9
The interplay of the cGAS–STING pathway with the lysosome	9
Textbook oxidative phosphorylation needs to be rewritten	9
RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer	9
cAMP signaling: a remarkably regional affair	8
Molecular determinants of protein evolvability	8
Advisory Board and Contents	8
Two for one: regulatory RNAs that encode small proteins	8
Insights into mitoribosomal biogenesis from recent structural studies	8
Coenzyme Q biochemistry and biosynthesis	8
Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology	8
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Diverse lineages and adaptations of oxygen-adapted hydrogenases	7
Trials and tribulations of statistical significance in biochemistry and omics	7
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	7
Advisory Board and Contents	7
Molecular design drives nanoarchitecture in self-assembling antimicrobial peptides	7
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Fine-tuning the connection between photorespiration and one-carbon metabolism	7
Creating overview and summary figures	7
Membranes as targets and modifiers of mutant huntingtin aggregation	7
Chemical probes for imaging cellular compartmentalization	7
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	7
The multifunctional, stress-sensitive ribonuclease angiogenin cross-regulates different gene expression processes	6
The multilayered regulation of aromatic amino acid biosynthesis in plants	6
Advisory Board and Contents	6
Advisory Board and Contents	6
Joan J. Guinovart (1947–2025)	6
Musings of a lab janitor: AI shenanigans	6
Z-DNA at the crossroads: untangling its role in genome dynamics	6
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time	6
Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins	6
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Understanding mitochondrial protein import: a revised model of the presequence translocase	6
Epigenetic regulation of circadian clocks by chromatin dynamics from fungi to mammals	6
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The evolving landscape of protein structure and molecular recognition	6