Trends in Biochemical Sciences

Article	Citations
Advisory Board and Contents	515
Subscription and Copyright Information	249
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	217
Conserved signaling gears that sustain circadian clock robustness	140
Subscription and Copyright Information	140
Advisory Board and Contents	139
Harnessing the power of peptides: advances and collaborations in biochemistry	135
Adding post-translational modifications and protein–protein interactions to protein schematics	133
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	122
Did circular DNA shape the evolution of mammalian genomes?	117
Novel machine learning approaches revolutionize protein knowledge	111
Understanding peptide hormones: from precursor proteins to bioactive molecules	105
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	104
Multiplayer virtual reality for understanding biomolecular structures	99
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	86
Parallels and crosstalk of ADP-ribosylation and ubiquitination	85
Decoding ceramide function: how localization shapes cellular fate and how to study it	79
Cellular oxidants and the proteostasis network: balance between activation and destruction	76
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	76
From lead to market: chemical approaches to transform peptides into therapeutics	72
Subconductance states add complexity to Piezo1 gating model	70
Microtubule nucleation for spindle assembly: one molecule at a time	69
Proteasome-derived peptides: separating the trash from the recycling	67
Bacterial transformation	66
Challenges of biomolecular science education in Africa and the way forward	66

Using graphs and charts in scientific figures	63
The transition phase: preparing to launch a laboratory	63
Exploring membrane asymmetry and its effects on membrane proteins	61
Transcription-coupled global genomic repair in E. coli	61
Mobile peptide and receptor complex mediates systemic stomatal immunity	59
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	57
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	55
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	55
Glucokinase: from allosteric glucose sensing to disease variants	55
Determining and interpreting protein lifetimes in mammalian tissues	55
Activation, decommissioning, and dememorization: enhancers in a life cycle	53
Transcription-coupled nucleosome assembly	52
Diverse heterochromatin states restricting cell identity and reprogramming	52
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	51
Autophagy regulation by phase separation, avidity, and wetting	51
Mitochondrial dynamics and pore formation in regulated cell death pathways	51
Creative approaches using proximity labeling to gain new biological insights	50
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	49
Orthogonal regulation of protein abundance	46
Subscription and Copyright Information	45
Making ends meet: a universal driver of large ribosomal subunit biogenesis	44
Seeing the forest through the trees: characterizing the glycoproteome	44
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	44
An outreach activity to enhance biochemistry pedagogy	43
Thiol dioxygenases: from structures to functions	43
Making nucleic acid structures and schematics	42
A plant immune protein fights against cancer	42
Advisory Board and Contents	41
Engineering RiPP pathways: strategies for generating complex bioactive peptides	39
Just bypass it: mechanisms of DNA damage tolerance	39
The metabolic code of ferroptosis: nutritional regulators of cell death	38
The RNA tether model for human chromosomal translocation fragile zones	38
Adenosine signals an imbalance between activity and supply in privileged cells	37
Functional modulation of chemical mediators in microbial communities	37
Control of chloroplast degradation and cell death in response to stress	37
Tandem repeats matter for the functional versatility of giant proteins	36
Pyruvylation: a link bridging metabolic disorders and impaired antiviral immunity	36
Innovations in the electron transport chain fuel archaeal methane metabolism	36
Two hearts beat as one: the debate over RAS dimers continues	35
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	35
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	34
The expanding landscape of canonical and non-canonical protein phosphorylation	34
Subscription and Copyright Information	34
Subscription and Copyright Information	33
Subscription and Copyright Information	33
Subscription and Copyright Information	33
Decoding disease-relevant variants with base and prime editors at scale	33
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	33
Convergent evolution in two bacterial replicative helicase loaders	33
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	33

Non-histone binding functions of PHD fingers	33
Zn2+ transients and signaling in mammalian systems	32
Metamorphic protein folding as evolutionary adaptation	32
Liquid–liquid phase separation in presynaptic nerve terminals	32
Advisory Board and Contents	31
Advisory Board and Contents	31
TiBS at 50	31
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	31
CryoEM shows the active dynein complex on microtubules	30
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	30
Orange carotenoid proteins: structural understanding of evolution and function	29
The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine	29
Recent advances in enzymes active on lignin-derived aromatic compounds	29
Programmable protein editing	29
Functional insights into the nitrogenase-like enzyme superfamily	29
Time-resolved serial crystallography to reveal protein structural changes	29
Proteostasis in cellular dormancy: lessons from yeast to oocytes	28
Forging a path toward a more sustainable laboratory	27
Cooperative assembly of the mitochondrial respiratory chain	27
Multifaceted control of T cell differentiation by STIM1	27
Does chromatin function as a metabolite reservoir?	27
The crosstalk of m6A-modified RNA with DNA damage repair	26
Advances, challenges, and opportunities in structural biology	25
Subscription and Copyright Information	25
Computationally guided AAV engineering for enhanced gene delivery	25
Advisory Board and Contents	25
E3 ubiquitin ligases in signaling, disease, and therapeutics	24
Advancing nanopore technology toward protein identification and sequencing	24
Advances in understanding aryl hydrocarbon receptor structure, function, and modulation	24
Powerful polymerases synthesize labeled RNA better, faster, stronger	24
TRAPs: the ‘elevator-with-an-operator’ mechanism	24
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	24
Monitoring subcellular NADP redox state with NAPstar biosensors	24
Advisory Board and Contents	23
Subscription and Copyright Information	23
Discordant skeletal muscle gene and protein responses to exercise	23
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	23
FN3K: the (un)sweetest kinase	23
Wrapping up a special series on scientific figure development	23
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	23
How to compile different types of structural visualizations in one panel	23
Oxytocin and vasopressin signaling in health and disease	22
Synaptoneurolipidomics: lipidomics in the study of synaptic function	22
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	22
Protein SUMOylation and phase separation: partners in stress?	22
To Ub or not to Ub: a regulatory question in TGF-β signaling	22
Endogenous plant nitroxyl, a new component of nitric oxide biology	22
SRC homology 3 domains: multifaceted binding modules	22
Discovering riboswitches: the past and the future	21
Enlightening epigenetics: optochemical tools illuminate the path	21
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	21
Advisory Board and Contents	21
Subscription and Copyright Information	20
Creating accessibility in academic negotiations	20
Maximizing grant funding: strategies for negotiating laboratory pricing	20
Protein Termini 2022: central roles of protein ends	20
Structural transitions modulate the chaperone activities of Grp94	20
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	19
Voices across Africa: from local challenges to global impact	19
Cytoplasmic gene expression: lessons from poxviruses	19
Spray-type modifications: an emerging paradigm in post-translational modifications	19
Mass spectrometry-based single-cell proteomics technologies, trends, and biological insights	19
Emerging roles and regulatory mechanisms involved in glutamine metabolism	19
The past, present, and future of RNA biochemistry and mitochondrial research	19
Emerging structural insights into PRC2 function in development and disease	18
Regulation of plant NLRs by post-translational modifications	18
Exploring nondegrading molecular glues for protein–protein interactions	18
Understanding the dynamic design of the spliceosome	18
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	18
Biomolecules capturing live bacteria from clinical samples	17
Subscription and Copyright Information	17
Advisory Board and Contents	16
A vigilant gliding bird protects plants	16
Adenosylhomocysteinase–adenosine complex links m6A and cancer lipid metabolism	16
Advisory Board and Contents	16
Thermal proteome profiling of protein-centric interactions and modifications	16
Using light to drive energy transduction in metazoan aging	16
Subscription and Copyright Information	16
Cytosolic AcCoA: a metabolic signal bridging nutrient sensing and mitophagy	16
Principles for the design of multispecific proteins	15

Integrated approaches for discovery and functional annotation of proteins of unknown function	15
Substrate and phosphorylation site selection by phosphoprotein phosphatases	15
Histone-mediated chromatin organization in prokaryotes and viruses	15
Mitochondria in disease: changes in shapes and dynamics	15
Inspiring discovery through reviews and visualization in biochemistry	15
From transcription to export: mRNA’s winding path to the cytoplasm	15
Subscription and Copyright Information	15
Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease	15
News about amino acid metabolism in plant–microbe interactions	15
Advisory Board and Contents	14
Subscription and Copyright Information	14
Subscription and Copyright Information	14
Advisory Board and Contents	14
The intersection of viral mimicry and nuclear entry	14
Subscription and Copyright Information	14
Post-translational modifications as key regulators of proline metabolism	14
Unlocking the protein code: how our organs age across a lifetime	14
Microtubule specialization by +TIP networks: from mechanisms to functional implications	14
Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design	14
Subscription and Copyright Information	13
The metabolic cross-talk between cancer and T cells	13
Consequences of telomere replication failure: the other end-replication problem	13
The quest to identify ADP-ribosylation readers: methodological advances	13
Mechanisms and rationales of SAM homeostasis	13
How do plants feel the heat and survive?	13
Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells	13
Systems-level modeling: Capturing the true complexity of disease	13
Mining the gut microbiota for defluorination activity	12
Subscription and Copyright Information	12
LncRNAs: the missing link to senescence nuclear architecture	12
Subscription and Copyright Information	12
Looking lively: emerging principles of pseudokinase signaling	12
The Integrator–PP2A complex integrates promoter-proximal premature termination with chromatin context and genome maintenance	12
Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier	12
Confluence and convergence of Dscam and Pcdh cell-recognition codes	12
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions	12
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain	12
Giant variations in giant virus genome packaging	12
Unlocking translational machinery for antitubercular drug development	12
The physiological relevance of autophagosome morphogenesis	12
Mitochondrial heat production: the elephant in the lab…	12
Important questions and future directions in plant biochemistry	12
Biogenesis and engineering of interleukin 12 family cytokines	11
ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising	11
Insights into mitoribosomal biogenesis from recent structural studies	11
Biosensor for monitoring PTEN activity in biological systems	11
Assembling the jigsaw puzzle of life	11
The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases	10
Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology	10
Textbook oxidative phosphorylation needs to be rewritten	10
RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer	10
The interplay of the cGAS–STING pathway with the lysosome	10
Anti-type VI tactics: bacterial defenses against type VI secretion system attacks	10
Molecular determinants of protein evolvability	10
Building a laboratory and networks during the COVID-19 pandemic	9
Functional diversity, evolution, and translational potential of isoprenoids in eukaryotic membranes	9
Advisory Board and Contents	9
cAMP signaling: a remarkably regional affair	9
Back on the chain gang: polyphosphate modification of proteins	9
Creating overview and summary figures	9
Ensembles of synthetic polymers mimic biological fluids	9
Two for one: regulatory RNAs that encode small proteins	9
Coenzyme Q biochemistry and biosynthesis	9
Subscription and Copyright Information	9
Subscription and Copyright Information	8
Z-DNA at the crossroads: untangling its role in genome dynamics	8
The multifunctional, stress-sensitive ribonuclease angiogenin cross-regulates different gene expression processes	8
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	8
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	8
Musings of a lab janitor: AI shenanigans	8
Fine-tuning the connection between photorespiration and one-carbon metabolism	8
Advisory Board and Contents	8
Subscription and Copyright Information	8
Molecular design drives nanoarchitecture in self-assembling antimicrobial peptides	8
Chemical probes for imaging cellular compartmentalization	8
Membranes as targets and modifiers of mutant huntingtin aggregation	8
The multilayered regulation of aromatic amino acid biosynthesis in plants	7
Mps1 kinase functions in mitotic spindle assembly and error correction	7
Subscription and Copyright Information	7
Joan J. Guinovart (1947–2025)	7
Trials and tribulations of statistical significance in biochemistry and omics	7
Diverse lineages and adaptations of oxygen-adapted hydrogenases	7
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time	7
Advisory Board and Contents	7
Assembly and function of branched ubiquitin chains	7
Understanding mitochondrial protein import: a revised model of the presequence translocase	7
Advisory Board and Contents	7
Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins	7
Machine learning and protein allostery	6
Advancing sustainable biotechnology through protein engineering	6
Subscription and Copyright Information	6
mRNA accessibility within mRNPs as a determinant of gene expression	6
Expanding enzyme functionality through site-specific incorporation of noncanonical amino acids	6
Cell surface RNA biology: new roles for RNA binding proteins	6
Mapping rRNA, tRNA, and mRNA modifications in ribosomes at high resolution	6