Trends in Biochemical Sciences

Article	Citations
Advisory Board and Contents	370
Decoding ceramide function: how localization shapes cellular fate and how to study it	206
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	182
From lead to market: chemical approaches to transform peptides into therapeutics	171
Did circular DNA shape the evolution of mammalian genomes?	108
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	107
Understanding peptide hormones: from precursor proteins to bioactive molecules	104
Adding post-translational modifications and protein–protein interactions to protein schematics	102
Multiplayer virtual reality for understanding biomolecular structures	97
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System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	89
Subscription and Copyright Information	86
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Exploiting enzyme evolution for computational protein design	82
Harnessing the power of peptides: advances and collaborations in biochemistry	81
Advisory Board and Contents	81
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	79
Conserved signaling gears that sustain circadian clock robustness	75
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	74
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	68
Molecular mechanisms of heat shock factor 1 regulation	67
Cellular oxidants and the proteostasis network: balance between activation and destruction	67
Novel machine learning approaches revolutionize protein knowledge	64
Subconductance states add complexity to Piezo1 gating model	63
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	63

Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	62
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	61
Glucokinase: from allosteric glucose sensing to disease variants	60
Structural parasitology of the malaria parasite Plasmodium falciparum	59
Microtubule nucleation for spindle assembly: one molecule at a time	59
Using graphs and charts in scientific figures	57
The transition phase: preparing to launch a laboratory	57
Transcription-coupled global genomic repair in E. coli	56
Diverse heterochromatin states restricting cell identity and reprogramming	53
Mitochondrial dynamics and pore formation in regulated cell death pathways	51
Activation, decommissioning, and dememorization: enhancers in a life cycle	50
Transcription-coupled nucleosome assembly	50
Determining and interpreting protein lifetimes in mammalian tissues	49
Proteasome-derived peptides: separating the trash from the recycling	49
Creative approaches using proximity labeling to gain new biological insights	48
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	48
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	48
Exploring membrane asymmetry and its effects on membrane proteins	45
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	45
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Two hearts beat as one: the debate over RAS dimers continues	42
Functional modulation of chemical mediators in microbial communities	42
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	42
The expanding landscape of canonical and non-canonical protein phosphorylation	41
Engineering RiPP pathways: strategies for generating complex bioactive peptides	41
An outreach activity to enhance biochemistry pedagogy	41
The RNA tether model for human chromosomal translocation fragile zones	41
A plant immune protein fights against cancer	41
Thiol dioxygenases: from structures to functions	41
Apart, together	41
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	39
Making nucleic acid structures and schematics	39
Control of chloroplast degradation and cell death in response to stress	38
Advisory Board and Contents	37
Making ends meet: a universal driver of large ribosomal subunit biogenesis	37
The metabolic code of ferroptosis: nutritional regulators of cell death	36
Seeing the forest through the trees: characterizing the glycoproteome	36
Just bypass it: mechanisms of DNA damage tolerance	36
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	34
Innovations in the electron transport chain fuel archaeal methane metabolism	34
Mitochondrial compartmentalization: emerging themes in structure and function	34
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	33
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Cloud computing platforms to support cryo-EM structure determination	32
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Liquid–liquid phase separation in presynaptic nerve terminals	30
Metamorphic protein folding as evolutionary adaptation	30
Non-histone binding functions of PHD fingers	30
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	30
Zn2+ transients and signaling in mammalian systems	30

Advisory Board and Contents	29
Convergent evolution in two bacterial replicative helicase loaders	29
Advisory Board and Contents	29
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	29
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
Time-resolved serial crystallography to reveal protein structural changes	28
Multifaceted control of T cell differentiation by STIM1	28
Orange carotenoid proteins: structural understanding of evolution and function	28
Circular RNAs in physiology and non-immunological diseases	27
Proteostasis in cellular dormancy: lessons from yeast to oocytes	27
Recent advances in enzymes active on lignin-derived aromatic compounds	27
CryoEM shows the active dynein complex on microtubules	26
Programmable protein editing	26
Cooperative assembly of the mitochondrial respiratory chain	26
The crosstalk of m6A-modified RNA with DNA damage repair	26
Forging a path toward a more sustainable laboratory	26
Does chromatin function as a metabolite reservoir?	26
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	25
Monitoring subcellular NADP redox state with NAPstar biosensors	25
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E3 ubiquitin ligases in signaling, disease, and therapeutics	24
Advancing nanopore technology toward protein identification and sequencing	24
TRAPs: the ‘elevator-with-an-operator’ mechanism	24
Computationally guided AAV engineering for enhanced gene delivery	24
Lysines and cysteines: partners in stress?	24
Advances, challenges, and opportunities in structural biology	23
FN3K: the (un)sweetest kinase	23
Discovering riboswitches: the past and the future	23
Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	23
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	23
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	22
SRC homology 3 domains: multifaceted binding modules	22
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	22
To Ub or not to Ub: a regulatory question in TGF-β signaling	22
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	21
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Wrapping up a special series on scientific figure development	21
Synaptoneurolipidomics: lipidomics in the study of synaptic function	20
Endogenous plant nitroxyl, a new component of nitric oxide biology	20
How integrin phosphorylations regulate cell adhesion and signaling	20
Discordant skeletal muscle gene and protein responses to exercise	20
How to compile different types of structural visualizations in one panel	20
Oxytocin and vasopressin signaling in health and disease	19
Advisory Board and Contents	19
Protein SUMOylation and phase separation: partners in stress?	19
Enlightening epigenetics: optochemical tools illuminate the path	18
Maximizing grant funding: strategies for negotiating laboratory pricing	18
Spray-type modifications: an emerging paradigm in post-translational modifications	18
Structural transitions modulate the chaperone activities of Grp94	18
Uncovering viral RNA–host cell interactions on a proteome-wide scale	18
Cytoplasmic gene expression: lessons from poxviruses	18
Creating accessibility in academic negotiations	18
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Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	17
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The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	17
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Exploring nondegrading molecular glues for protein–protein interactions	17
Protein Termini 2022: central roles of protein ends	17
Biomolecules capturing live bacteria from clinical samples	17
Advisory Board and Contents	17
Understanding the dynamic design of the spliceosome	17
News about amino acid metabolism in plant–microbe interactions	16
A vigilant gliding bird protects plants	16
Film-like organelles equip cells with multiple genetic codes	16
Advisory Board and Contents	16
Using light to drive energy transduction in metazoan aging	16
Advisory Board and Contents	16
Substrate and phosphorylation site selection by phosphoprotein phosphatases	16
Thermal proteome profiling of protein-centric interactions and modifications	15
Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design	15
The intersection of viral mimicry and nuclear entry	15
The lysosome as a master regulator of iron metabolism	15
Mitochondria in disease: changes in shapes and dynamics	15
From transcription to export: mRNA’s winding path to the cytoplasm	15
Coupling lipid synthesis with nuclear envelope remodeling	15
Structural advances in sterol-sensing domain-containing proteins	15
Histone-mediated chromatin organization in prokaryotes and viruses	15
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Advisory Board and Contents	14

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Consequences of telomere replication failure: the other end-replication problem	14
Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy	14
Advisory Board and Contents	14
Translational control through ribosome heterogeneity and functional specialization	14
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The Integrator–PP2A complex integrates promoter-proximal premature termination with chromatin context and genome maintenance	13
LncRNAs: the missing link to senescence nuclear architecture	13
Mining the gut microbiota for defluorination activity	13
How do plants feel the heat and survive?	13
Microtubule specialization by +TIP networks: from mechanisms to functional implications	13
The metabolic cross-talk between cancer and T cells	13
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Unlocking translational machinery for antitubercular drug development	12
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?	12
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The enzymes for genome size increase and maintenance of large (+)RNA viruses	12
ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising	12
Mechanisms and rationales of SAM homeostasis	12
Looking lively: emerging principles of pseudokinase signaling	12
Confluence and convergence of Dscam and Pcdh cell-recognition codes	12
The quest to identify ADP-ribosylation readers: methodological advances	12
Textbook oxidative phosphorylation needs to be rewritten	12
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions	12
Molecular determinants of protein evolvability	12
Giant variations in giant virus genome packaging	12
Mitochondrial heat production: the elephant in the lab…	12
Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells	12
The physiological relevance of autophagosome morphogenesis	12
RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer	12
Assembling the jigsaw puzzle of life	11
Insights into mitoribosomal biogenesis from recent structural studies	11
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain	11
Important questions and future directions in plant biochemistry	11
Back on the chain gang: polyphosphate modification of proteins	11
Ensembles of synthetic polymers mimic biological fluids	11
The interplay of the cGAS–STING pathway with the lysosome	11
Advisory Board and Contents	10
Biosensor for monitoring PTEN activity in biological systems	10
Biogenesis and engineering of interleukin 12 family cytokines	10
Molecular design drives nanoarchitecture in self-assembling antimicrobial peptides	10
Building a laboratory and networks during the COVID-19 pandemic	10
Two for one: regulatory RNAs that encode small proteins	10
Coenzyme Q biochemistry and biosynthesis	10
cAMP signaling: a remarkably regional affair	10
The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases	10
Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology	10
Chemical probes for imaging cellular compartmentalization	10
Membranes as targets and modifiers of mutant huntingtin aggregation	9
Chemical genetic methodologies for identifying protein substrates of PARPs	9
The multilayered regulation of aromatic amino acid biosynthesis in plants	9
Mapping histone modification-dependent protein interactions with chemical proteomics	9
Advisory Board and Contents	9
Diverse lineages and adaptations of oxygen-adapted hydrogenases	9
Contributions of single-particle cryoelectron microscopy toward fighting COVID-19	9
Assembly and function of branched ubiquitin chains	8
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Mps1 kinase functions in mitotic spindle assembly and error correction	8
Trials and tribulations of statistical significance in biochemistry and omics	8
The emerging roles of S-acylation in autophagy	8
Creating overview and summary figures	8
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Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	8
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	8
Understanding mitochondrial protein import: a revised model of the presequence translocase	8
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Size does matter: piRNA and miRNA targeting	8
Frozen motion: how cryo-EM changes the way we look at ABC transporters	8
Z-DNA at the crossroads: untangling its role in genome dynamics	8
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time	7
Advisory Board and Contents	7
PML isoforms: a molecular basis for PML pleiotropic functions	7
Machine learning and protein allostery	7
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Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins	7
Advisory Board and Contents	7
IUBMB Trainee Initiative: supporting emerging biochemists and molecular biologists around the world	7
Endomembrane GPCR signaling: 15 years on, the quest continues	7
Structural basis of torque generation in the bi-directional bacterial flagellar motor	7
Joan J. Guinovart (1947–2025)	7
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Advisory Board and Contents	7
Mammalian viral suppressors of RNA interference	7
Protein–membrane interactions: sensing and generating curvature	6
Cell surface RNA biology: new roles for RNA binding proteins	6
Broadening access to cryoEM through centralized facilities	6
Type III CRISPR-Cas: beyond the Cas10 effector complex	6
BRCA1/BARD1 is a nucleosome reader and writer	6
Methods for the directed evolution of biomolecular interactions	6
How does p53 work? Regulation by the intrinsically disordered domains	6
Mapping rRNA, tRNA, and mRNA modifications in ribosomes at high resolution	6
mRNA accessibility within mRNPs as a determinant of gene expression	6
Recent structural advances towards understanding of the bacterial type III secretion injectisome	6
Actin finally matures: uncovering machinery and impact	5