Trends in Biochemical Sciences

Article	Citations
Subscription and Copyright Information	338
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Adding post-translational modifications and protein–protein interactions to protein schematics	157
Advisory Board and Contents	152
Multiplayer virtual reality for understanding biomolecular structures	147
Understanding peptide hormones: from precursor proteins to bioactive molecules	115
Harnessing the power of peptides: advances and collaborations in biochemistry	101
Advisory Board and Contents	100
Transporter Specificity: A Tale of Loosened Elevator-Sliding	95
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	94
Novel machine learning approaches revolutionize protein knowledge	93
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	91
Conserved signaling gears that sustain circadian clock robustness	88
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	82
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	78
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	78
Exploiting enzyme evolution for computational protein design	78
Did circular DNA shape the evolution of mammalian genomes?	73
Molecular mechanisms of heat shock factor 1 regulation	72
Cellular oxidants and the proteostasis network: balance between activation and destruction	72
Decoding ceramide function: how localization shapes cellular fate and how to study it	72
From lead to market: chemical approaches to transform peptides into therapeutics	70
Determining and interpreting protein lifetimes in mammalian tissues	69
Transcription-coupled global genomic repair in E. coli	67

Creative approaches using proximity labeling to gain new biological insights	62
Structural parasitology of the malaria parasite Plasmodium falciparum	61
Cell entry by SARS-CoV-2	61
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	60
Activation, decommissioning, and dememorization: enhancers in a life cycle	59
Using graphs and charts in scientific figures	57
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	57
Diverse heterochromatin states restricting cell identity and reprogramming	57
Subconductance states add complexity to Piezo1 gating model	56
Glucokinase: from allosteric glucose sensing to disease variants	55
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	55
Microtubule nucleation for spindle assembly: one molecule at a time	54
Proteasome-derived peptides: separating the trash from the recycling	53
Transcription-coupled nucleosome assembly	51
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	50
The transition phase: preparing to launch a laboratory	48
Exploring membrane asymmetry and its effects on membrane proteins	47
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	47
Apart, together	47
Engineering RiPP pathways: strategies for generating complex bioactive peptides	46
Advisory Board and Contents	46
Subscription and Copyright Information	45
The RNA tether model for human chromosomal translocation fragile zones	44
Making nucleic acid structures and schematics	43
Functional modulation of chemical mediators in microbial communities	43
Two hearts beat as one: the debate over RAS dimers continues	42
A plant immune protein fights against cancer	40
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	40
An outreach activity to enhance biochemistry pedagogy	40
Innovations in the electron transport chain fuel archaeal methane metabolism	39
Thiol dioxygenases: from structures to functions	39
Mitochondrial compartmentalization: emerging themes in structure and function	38
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	37
Seeing the forest through the trees: characterizing the glycoproteome	37
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	37
Just bypass it: mechanisms of DNA damage tolerance	35
The expanding landscape of canonical and non-canonical protein phosphorylation	35
Control of chloroplast degradation and cell death in response to stress	35
Making ends meet: a universal driver of large ribosomal subunit biogenesis	34
The metabolic code of ferroptosis: nutritional regulators of cell death	34
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Convergent evolution in two bacterial replicative helicase loaders	33
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Cloud computing platforms to support cryo-EM structure determination	33
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	32
Liquid–liquid phase separation in presynaptic nerve terminals	32
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	32
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	31
Non-histone binding functions of PHD fingers	31
Metamorphic protein folding as evolutionary adaptation	30

Origins and evolving functionalities of tRNA-derived small RNAs	29
Programmable protein editing	28
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
Recent advances in enzymes active on lignin-derived aromatic compounds	28
Advisory Board and Contents	28
Advisory Board and Contents	28
Proteostasis in cellular dormancy: lessons from yeast to oocytes	28
Does chromatin function as a metabolite reservoir?	28
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	28
Lamin post-translational modifications: emerging toggles of nuclear organization and function	27
Forging a path toward a more sustainable laboratory	27
Time-resolved serial crystallography to reveal protein structural changes	27
The crosstalk of m6A-modified RNA with DNA damage repair	26
CryoEM shows the active dynein complex on microtubules	26
Orange carotenoid proteins: structural understanding of evolution and function	26
Circular RNAs in physiology and non-immunological diseases	26
Multifaceted control of T cell differentiation by STIM1	26
Cooperative assembly of the mitochondrial respiratory chain	25
Lysines and cysteines: partners in stress?	25
Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	25
Advances, challenges, and opportunities in structural biology	25
Computationally guided AAV engineering for enhanced gene delivery	24
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Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	23
Advancing nanopore technology toward protein identification and sequencing	23
Lipidation status of single membrane-associated ATG8 proteins	23
Wrapping up a special series on scientific figure development	23
Monitoring subcellular NADP redox state with NAPstar biosensors	23
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How to compile different types of structural visualizations in one panel	23
TRAPs: the ‘elevator-with-an-operator’ mechanism	23
FN3K: the (un)sweetest kinase	23
Endogenous plant nitroxyl, a new component of nitric oxide biology	23
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	22
Oxytocin and vasopressin signaling in health and disease	22
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	21
Protein SUMOylation and phase separation: partners in stress?	21
SRC homology 3 domains: multifaceted binding modules	21
How integrin phosphorylations regulate cell adhesion and signaling	20
Synaptoneurolipidomics: lipidomics in the study of synaptic function	20
Discordant skeletal muscle gene and protein responses to exercise	20
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	20
To Ub or not to Ub: a regulatory question in TGF-β signaling	20
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	20
Discovering riboswitches: the past and the future	20
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Maximizing grant funding: strategies for negotiating laboratory pricing	18
Biomolecules capturing live bacteria from clinical samples	18
Spray-type modifications: an emerging paradigm in post-translational modifications	18
Advisory Board and Contents	18
Understanding the dynamic design of the spliceosome	18
Mitochondrial DNA: cellular genotoxic stress sentinel	18
Enlightening epigenetics: optochemical tools illuminate the path	18
Protein Termini 2022: central roles of protein ends	18
Cytoplasmic gene expression: lessons from poxviruses	18
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Creating accessibility in academic negotiations	17
Uncovering viral RNA–host cell interactions on a proteome-wide scale	17
Take Your PIC	17
Structural transitions modulate the chaperone activities of Grp94	17
Exploring nondegrading molecular glues for protein–protein interactions	17
Advisory Board and Contents	17
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	17
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	17
Advisory Board and Contents	16
Advisory Board and Contents	16
Film-like organelles equip cells with multiple genetic codes	16
Transforming eukaryotic cell culture with macromolecular crowding	16
A vigilant gliding bird protects plants	16
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Using light to drive energy transduction in metazoan aging	15
Structural advances in sterol-sensing domain-containing proteins	15
Substrate and phosphorylation site selection by phosphoprotein phosphatases	15
Thermal proteome profiling of protein-centric interactions and modifications	15
Coupling lipid synthesis with nuclear envelope remodeling	15
Advisory Board and Contents	14
News about amino acid metabolism in plant–microbe interactions	14
The lysosome as a master regulator of iron metabolism	14
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Mitochondria in disease: changes in shapes and dynamics	14

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Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design	13
The intersection of viral mimicry and nuclear entry	13
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From transcription to export: mRNA’s winding path to the cytoplasm	13
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Advisory Board and Contents	13
Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy	13
Consequences of telomere replication failure: the other end-replication problem	13
How do plants feel the heat and survive?	12
Unlocking translational machinery for antitubercular drug development	12
The quest to identify ADP-ribosylation readers: methodological advances	12
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?	12
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Microtubule specialization by +TIP networks: from mechanisms to functional implications	12
The enzymes for genome size increase and maintenance of large (+)RNA viruses	12
Giant variations in giant virus genome packaging	12
Histone-mediated chromatin organization in prokaryotes and viruses	12
Translational control through ribosome heterogeneity and functional specialization	12
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Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells	12
The physiological relevance of autophagosome morphogenesis	12
LncRNAs: the missing link to senescence nuclear architecture	11
Mitochondrial heat production: the elephant in the lab…	11
Mechanisms of Gβγ Release upon GPCR Activation	11
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions	11
Looking lively: emerging principles of pseudokinase signaling	11
Confluence and convergence of Dscam and Pcdh cell-recognition codes	11
Mechanisms and rationales of SAM homeostasis	11
ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising	11
Mining the gut microbiota for defluorination activity	11
The metabolic cross-talk between cancer and T cells	11
Advisory Board and Contents	11
Building a laboratory and networks during the COVID-19 pandemic	11
Ensembles of synthetic polymers mimic biological fluids	10
Assembling the jigsaw puzzle of life	10
Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology	10
Textbook oxidative phosphorylation needs to be rewritten	10
RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer	10
Back on the chain gang: polyphosphate modification of proteins	10
Biosensor for monitoring PTEN activity in biological systems	10
cAMP signaling: a remarkably regional affair	10
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain	10
Important questions and future directions in plant biochemistry	10
Two for one: regulatory RNAs that encode small proteins	10
Biogenesis and engineering of interleukin 12 family cytokines	10
The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases	9
Chemical probes for imaging cellular compartmentalization	9
Insights into mitoribosomal biogenesis from recent structural studies	9
Coenzyme Q biochemistry and biosynthesis	9
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Molecular determinants of protein evolvability	9
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Creating overview and summary figures	9
Size does matter: piRNA and miRNA targeting	8
Chemical genetic methodologies for identifying protein substrates of PARPs	8
The multilayered regulation of aromatic amino acid biosynthesis in plants	8
Assembly and function of branched ubiquitin chains	8
Mapping histone modification-dependent protein interactions with chemical proteomics	8
Trials and tribulations of statistical significance in biochemistry and omics	8
Contributions of single-particle cryoelectron microscopy toward fighting COVID-19	8
Z-DNA at the crossroads: untangling its role in genome dynamics	8
Understanding mitochondrial protein import: a revised model of the presequence translocase	8
Mps1 kinase functions in mitotic spindle assembly and error correction	8
Diverse lineages and adaptations of oxygen-adapted hydrogenases	8
Advisory Board and Contents	8
Molecular design drives nanoarchitecture in self-assembling antimicrobial peptides	8
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Frozen motion: how cryo-EM changes the way we look at ABC transporters	7
Advisory Board and Contents	7
The emerging roles of S-acylation in autophagy	7
Detecting and Rescuing Stalled Ribosomes	7
Advisory Board and Contents	7
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	7
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Characterizing Circular RNAs Using Nanopore Sequencing	7
Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins	7
Joan J. Guinovart (1947–2025)	7
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	7
Advisory Board and Contents	7
Endomembrane GPCR signaling: 15 years on, the quest continues	7
Structural basis of torque generation in the bi-directional bacterial flagellar motor	7
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time	7
PML isoforms: a molecular basis for PML pleiotropic functions	6
Mammalian viral suppressors of RNA interference	6
Cell surface RNA biology: new roles for RNA binding proteins	6
Machine learning and protein allostery	6
Broadening access to cryoEM through centralized facilities	6
Interplay of cGAS with chromatin	6
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IUBMB Trainee Initiative: supporting emerging biochemists and molecular biologists around the world	6
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ADAR RNA Modifications, the Epitranscriptome and Innate Immunity	5
Incorporating chemical structures into scientific figures	5
Targeting the nucleolus as a therapeutic strategy in human disease	5