Trends in Biochemical Sciences

Papers
(The median citation count of Trends in Biochemical Sciences is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Biomolecular Condensates in the Nucleus243
Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy211
The SLC25 Mitochondrial Carrier Family: Structure and Mechanism180
Mechanisms and Functions of Chromosome Compartmentalization149
FUS and TDP-43 Phases in Health and Disease144
Mechanisms and Regulation of RNA Condensation in RNP Granule Formation129
Reciprocal Regulation of Mitochondrial Fission and Fusion120
Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases113
Cell entry by SARS-CoV-2111
Structure and Roles of V-type ATPases110
Hippo Signaling in Embryogenesis and Development109
Autophagy Assays for Biological Discovery and Therapeutic Development95
Single-Cell Proteomics90
G-Quadruplexes in RNA Biology: Recent Advances and Future Directions87
Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis81
YAP and TAZ Are Not Identical Twins79
How Lysosomes Sense, Integrate, and Cope with Stress78
The Cytoskeleton as Regulator of Cell Signaling Pathways76
Cytosolic Events in the Biogenesis of Mitochondrial Proteins75
Origins and evolving functionalities of tRNA-derived small RNAs73
Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells73
Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels72
Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria68
Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity68
To Eat or to Die: Deciphering Selective Forms of Autophagy67
The lysosome as a master regulator of iron metabolism65
Extracellular miRNAs and Cell–Cell Communication: Problems and Prospects65
Functional Diversification of ER Stress Responses in Arabidopsis64
Beyond Autophagy: The Expanding Roles of ATG8 Proteins63
Mechanisms of Long Noncoding RNA Nuclear Retention62
One Ring to Rule them All? Structural and Functional Diversity in the Nuclear Pore Complex62
Coordinating gene expression during the cell cycle62
ADAR RNA Modifications, the Epitranscriptome and Innate Immunity62
Myristoylation, an Ancient Protein Modification Mirroring Eukaryogenesis and Evolution62
Circular RNAs in Immune Response and Viral Infection60
ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease59
Coupling of Ribosome Synthesis and Translational Capacity with Cell Growth58
Nothing Is Yet Set in (Hi)stone: Novel Post-Translational Modifications Regulating Chromatin Function58
The Golgi as an Assembly Line to the Autophagosome58
Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo57
Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling57
Histone Lactylation: A New Role for Glucose Metabolism57
Emerging Insights into the Structure and Function of Complement C5a Receptors55
Histone Tail Conformations: A Fuzzy Affair with DNA53
The NLRP3 inflammasome: activation and regulation53
A Chain of Events: Regulating Target Proteins by SUMO Polymers53
Discovering riboswitches: the past and the future52
Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function51
Direct Structural Insights into GABAA Receptor Pharmacology51
Activation and Regulation of Cytoplasmic Dynein51
Metabolism and the Epigenome: A Dynamic Relationship51
Phytochemicals as Prebiotics and Biological Stress Inducers50
Biomolecular Condensates and Their Links to Cancer Progression50
Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications50
Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis50
Mitochondrial DNA: cellular genotoxic stress sentinel47
Rapid Detection and Signaling of DNA Damage by PARP-146
Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation46
Regulation of Autophagy Enzymes by Nutrient Signaling43
The Retromer Complex: From Genesis to Revelations43
Translational control through ribosome heterogeneity and functional specialization43
Chaperone Machineries of Rubisco – The Most Abundant Enzyme42
How Cells Respond to DNA Breaks in Mitosis42
A Tour of TOR Complex Signaling in Plants42
Molecular Determinants of Flavivirus Virion Assembly42
Revisiting Extracellular RNA Release, Processing, and Function41
A Unifying Mechanism of DNA Translocation Underlying Chromatin Remodeling41
How do plants feel the heat and survive?41
Genetically Encodable Fluorescent and Bioluminescent Biosensors Light Up Signaling Networks41
Drug discovery in the era of cryo-electron microscopy40
The Wide World of Coacervates: From the Sea to Neurodegeneration39
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective39
The Hammer and the Dance of Cell Cycle Control39
Molecular mechanisms of heat shock factor 1 regulation39
Spirits in the Material World: Enhancer RNAs in Transcriptional Regulation37
Divalent Cations: A Molecular Glue for Protein Materials37
Miniproteins as a Powerful Modality in Drug Development36
Integrins Control Vesicular Trafficking; New Tricks for Old Dogs36
The Integrator Complex in Transcription and Development35
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting35
The Evolution of STING Signaling and Its Involvement in Cancer35
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?35
The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis35
Gene-Specific Actions of Transcriptional Coregulators Facilitate Physiological Plasticity: Evidence for a Physiological Coregulator Code34
Nonredundant Roles of GRASP55 and GRASP65 in the Golgi Apparatus and Beyond34
Detecting and Rescuing Stalled Ribosomes34
Big-Data Glycomics: Tools to Connect Glycan Biosynthesis to Extracellular Communication34
Emerging Roles of tRNAs in RNA Virus Infections33
Assembly and function of branched ubiquitin chains33
Canary in a coal mine: collided ribosomes as sensors of cellular conditions33
Nucleic Acid-Based Technologies Targeting Coronaviruses33
DEAH-Box RNA Helicases in Pre-mRNA Splicing33
Mimicry of Short Linear Motifs by Bacterial Pathogens: A Drugging Opportunity33
Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks33
N-Terminal Proteoforms in Human Disease32
Art and Science of the Cellular Mesoscale32
How Hierarchical Interactions Make Membraneless Organelles Tick Like Clockwork32
Global Approaches in Studying RNA-Binding Protein Interaction Networks32
Control of chloroplast degradation and cell death in response to stress31
Mitochondrial compartmentalization: emerging themes in structure and function31
Charting a DNA Repair Roadmap for Immunoglobulin Class Switch Recombination31
Structural basis of torque generation in the bi-directional bacterial flagellar motor31
Complementarity of Hydrogen/Deuterium Exchange Mass Spectrometry and Cryo-Electron Microscopy30
Striking Diversity of Mitochondria-Specific Translation Processes across Eukaryotes30
Mentoring during Uncertain Times30
A roadmap for rRNA folding and assembly during transcription29
Molecular Mobility-Mediated Regulation of E-Cadherin Adhesion29
Circular RNAs in physiology and non-immunological diseases29
Galvanization of Protein–Protein Interactions in a Dynamic Zinc Interactome28
News about amino acid metabolism in plant–microbe interactions28
Limiting the DNA Double-Strand Break Resectosome for Genome Protection27
Emerging Features of Linear Motif-Binding Hub Proteins27
Advances in the World of Bacterial Microcompartments27
Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling26
Therapeutic targeting of TEAD transcription factors in cancer26
The Life Cycle of the Mu-Opioid Receptor26
Methods to Study Phase-Separated Condensates and the Underlying Molecular Interactions26
The Autophagy–RNA Interplay: Degradation and Beyond25
N6-Methyladenosine Regulates Host Responses to Viral Infection25
Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues24
Plant biochemistry influences tropospheric ozone formation, destruction, deposition, and response24
The many faces of RNA-based RNase P, an RNA-world relic24
The Mediator kinase module: an interface between cell signaling and transcription23
Time to target the circadian clock for drug discovery23
COVID-19 Vaccines Based on Adenovirus Vectors22
The broader sense of nonsense22
Molecular Mechanisms of Lysosome and Nucleus Communication22
Nucleosomes Meet Their Remodeler Match22
Coupling lipid synthesis with nuclear envelope remodeling22
Non-enzymatic Covalent Modifications as a New Chapter in the Histone Code22
MicroRNA turnover: a tale of tailing, trimming, and targets22
How integrin phosphorylations regulate cell adhesion and signaling22
Are Parallel Proliferation Pathways Redundant?21
Novel machine learning approaches revolutionize protein knowledge21
Transforming eukaryotic cell culture with macromolecular crowding21
Creating memories: molecular mechanisms of CRISPR adaptation21
A Tale of Two Moieties: Rapidly Evolving CRISPR/Cas-Based Genome Editing21
Linker Domains: Why ABC Transporters ‘Live in Fragments no Longer’20
Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines20
Ribosomal DNA and the nucleolus at the heart of aging20
DNA Processing in the Context of Noncoding Transcription20
Plasmon-Driven Ultrafast Photonic PCR20
Completing the canvas: advances and challenges for DNA-PAINT super-resolution imaging20
PI3K functions as a hub in mechanotransduction20
Coenzyme Q biochemistry and biosynthesis19
Uncovering viral RNA–host cell interactions on a proteome-wide scale19
Shedding Light on the Ghost Proteome19
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum19
Integrating adipocyte insulin signaling and metabolism in the multi-omics era19
Detecting Protein–Small Molecule Interactions Using Limited Proteolysis–Mass Spectrometry (LiP-MS)19
The Structure of ASFV Advances the Fight against the Disease19
Interaction modules that impart specificity to disordered protein18
Proteasome substrate receptors and their therapeutic potential18
Computational Dissection of Membrane Transport at a Microscopic Level18
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics17
On the Cutting Edge: Regulation and Therapeutic Potential of the mRNA 3′ End Nuclease17
Cooperative assembly of the mitochondrial respiratory chain17
Lamin post-translational modifications: emerging toggles of nuclear organization and function16
Seeing Atoms by Single-Particle Cryo-EM16
Who let the DoGs out? – biogenesis of stress-induced readthrough transcripts16
Molecular Dynamics Simulations of Ion Channels16
Strategies for Engineering and Rewiring Kinase Regulation16
Balancing the Opposing Principles That Govern Peroxisome Homeostasis16
Interplay of cGAS with chromatin16
Next-Generation Pathology by Multiplexed Immunohistochemistry15
Protein Amyloid Cofactors: Charged Side-Chain Arrays Meet Their Match?15
Consequences of telomere replication failure: the other end-replication problem14
To Ub or not to Ub: a regulatory question in TGF-β signaling14
Do All Roads Lead to Rome in G-Protein Activation?14
Coupling Conjugation and Deconjugation Activities to Achieve Cellular Ubiquitin Dynamics14
Transporter Specificity: A Tale of Loosened Elevator-Sliding14
Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine14
Current View of Ligand and Lipid Recognition by the Menthol Receptor TRPM814
Monitoring Proteolytic Activity in Real Time: A New World of Opportunities for Biosensors13
Chaperoning shape-shifting tau in disease13
Crowding revisited: Open questions and future perspectives13
Exploiting enzyme evolution for computational protein design13
Deconstructing the transmembrane core of class A G protein–coupled receptors13
A Role for N6-Methyladenine in DNA Damage Repair13
Targeting the nucleolus as a therapeutic strategy in human disease13
SLC16 Family: From Atomic Structure to Human Disease13
BRCA1/BARD1 is a nucleosome reader and writer13
NAADP-binding proteins find their identity13
Let’s phase it: viruses are master architects of biomolecular condensates13
A NuRD for all seasons13
Spot the Difference: Function versus Toxicity in Amyloid Fibrils12
Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy12
Beyond the marks: reader-effectors as drivers of epigenetics and chromatin engineering12
Structural advances in sterol-sensing domain-containing proteins12
Advances in computational methods for ligand binding kinetics11
Determining and interpreting protein lifetimes in mammalian tissues11
Structures, Mechanisms, and Functions of His-Me Finger Nucleases11
Mechanistic insights into the versatile class II CRISPR toolbox11
Protein kinase C: release from quarantine by mTORC211
Microbial Prions: Dawn of a New Era11
Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers11
SRC homology 3 domains: multifaceted binding modules11
Controlling the Controllers: Regulation of Histone Methylation by Phosphosignalling10
Using 3D Animation to Visualize Hypotheses10
Mammalian viral suppressors of RNA interference10
Unconventional secretion mediated by direct protein self-translocation across the plasma membranes of mammalian cells10
ProP-PD for proteome-wide motif-mediated interaction discovery10
Roles and dynamics of 3-methylcytidine in cellular RNAs10
Cryo-electron tomography of enveloped viruses10
Intrinsically disordered regions are poised to act as sensors of cellular chemistry10
Seeing the forest through the trees: characterizing the glycoproteome10
The spindle checkpoint proteins BUB1 and BUBR1: (SLiM)ming down to the basics10
Chemical genetic methodologies for identifying protein substrates of PARPs10
SLiM-binding pockets: an attractive target for broad-spectrum antivirals9
Broadening access to cryoEM through centralized facilities9
Frozen motion: how cryo-EM changes the way we look at ABC transporters9
The space between notes: emerging roles for translationally silent ribosomes9
PML isoforms: a molecular basis for PML pleiotropic functions9
NAD-capped RNAs – a redox cofactor meets RNA9
Time management for STEMM students during the continuing pandemic9
Reshaping Chromatin Architecture around DNA Breaks9
Inheritance of Histone (H3/H4): A Binary Choice?8
Redox Biochemistry of the Genetic Code8
Structural Basis for the Modulation of Ryanodine Receptors8
Looking lively: emerging principles of pseudokinase signaling8
Characterizing Circular RNAs Using Nanopore Sequencing8
Reciprocal Links between Pre-messenger RNA 3′-End Processing and Genome Stability8
cCMP and cUMP come into the spotlight, finally8
Transcriptional lockdown during acute proteotoxic stress7
Roles of zinc-binding domain of bacterial RNA polymerase in transcription7
Jekyll and Hyde: Activating the Hypoxic Translational Machinery7
The Trinity of SPRTN Protease Regulation7
Recent structural advances towards understanding of the bacterial type III secretion injectisome7
NCBP3: A Multifaceted Adaptive Regulator of Gene Expression7
Structural view of G protein-coupled receptor signaling in the retinal rod outer segment7
The enzymes for genome size increase and maintenance of large (+)RNA viruses7
Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases7
Convergent evolution in two bacterial replicative helicase loaders7
Say Cheese: Structure of the Cardiac Electrical Engine Is Captured7
Biogenesis and engineering of interleukin 12 family cytokines7
H2A.Z's ‘social’ network: functional partners of an enigmatic histone variant7
Metabolic Flux Analysis: Moving beyond Static Metabolomics7
DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles7
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers7
Cytoplasmic gene expression: lessons from poxviruses7
Contributions of single-particle cryoelectron microscopy toward fighting COVID-196
NLR signaling in plants: from resistosomes to second messengers6
Proteomic Technologies for Deciphering Local and Global Protein Interactions6
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions6
Activity-based annotation: the emergence of systems biochemistry6
The twisted path of the 3D genome: where does it lead?6
Protein SUMOylation and phase separation: partners in stress?6
Is a cure for Parkinson’s disease hiding inside us?6
Ultrahigh-throughput screening in microfluidic droplets: a faster route to new enzymes6
Machine learning and protein allostery6
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