Trends in Biochemical Sciences

Article	Citations
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System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	156
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Adding post-translational modifications and protein–protein interactions to protein schematics	144
Advisory Board and Contents	139
From lead to market: chemical approaches to transform peptides into therapeutics	135
Multiplayer virtual reality for understanding biomolecular structures	132
Advisory Board and Contents	121
Decoding ceramide function: how localization shapes cellular fate and how to study it	113
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	107
Novel machine learning approaches revolutionize protein knowledge	96
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	96
Did circular DNA shape the evolution of mammalian genomes?	90
Understanding peptide hormones: from precursor proteins to bioactive molecules	88
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	86
Cellular oxidants and the proteostasis network: balance between activation and destruction	86
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	85
Molecular mechanisms of heat shock factor 1 regulation	85
Transporter Specificity: A Tale of Loosened Elevator-Sliding	83
Exploiting enzyme evolution for computational protein design	81
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The transition phase: preparing to launch a laboratory	77
Glucokinase: from allosteric glucose sensing to disease variants	74
Determining and interpreting protein lifetimes in mammalian tissues	74

Activation, decommissioning, and dememorization: enhancers in a life cycle	73
Transcription-coupled global genomic repair in E. coli	70
Diverse heterochromatin states restricting cell identity and reprogramming	69
Subconductance states add complexity to Piezo1 gating model	67
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	66
Microtubule nucleation for spindle assembly: one molecule at a time	66
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	66
Exploring membrane asymmetry and its effects on membrane proteins	65
Transcription-coupled nucleosome assembly	64
Structural parasitology of the malaria parasite Plasmodium falciparum	62
Using graphs and charts in scientific figures	62
Cell entry by SARS-CoV-2	59
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	57
Creative approaches using proximity labeling to gain new biological insights	55
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	55
FUS and TDP-43 Phases in Health and Disease	54
Apart, together	54
Advisory Board and Contents	52
Innovations in the electron transport chain fuel archaeal methane metabolism	51
Seeing the forest through the trees: characterizing the glycoproteome	50
The expanding landscape of canonical and non-canonical protein phosphorylation	49
Control of chloroplast degradation and cell death in response to stress	49
Mitochondrial compartmentalization: emerging themes in structure and function	48
Making nucleic acid structures and schematics	46
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	46
Making ends meet: a universal driver of large ribosomal subunit biogenesis	46
A plant immune protein fights against cancer	44
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	44
The RNA tether model for human chromosomal translocation fragile zones	43
Two hearts beat as one: the debate over RAS dimers continues	42
Thiol dioxygenases: from structures to functions	42
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Functional modulation of chemical mediators in microbial communities	41
An outreach activity to enhance biochemistry pedagogy	41
Direct Structural Insights into GABAA Receptor Pharmacology	41
Non-histone binding functions of PHD fingers	40
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Cloud computing platforms to support cryo-EM structure determination	40
Convergent evolution in two bacterial replicative helicase loaders	39
Metamorphic protein folding as evolutionary adaptation	39
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	39
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	38
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	38
Origins and evolving functionalities of tRNA-derived small RNAs	36
Liquid–liquid phase separation in presynaptic nerve terminals	36
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	36
Multifaceted control of T cell differentiation by STIM1	35
Advisory Board and Contents	35
Does chromatin function as a metabolite reservoir?	35
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Time-resolved serial crystallography to reveal protein structural changes	34
Cooperative assembly of the mitochondrial respiratory chain	34
CryoEM shows the active dynein complex on microtubules	34
Orange carotenoid proteins: structural understanding of evolution and function	31
Recent advances in enzymes active on lignin-derived aromatic compounds	31
Advisory Board and Contents	31
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	31
Forging a path toward a more sustainable laboratory	31
Circular RNAs in physiology and non-immunological diseases	30
Lamin post-translational modifications: emerging toggles of nuclear organization and function	28
Advances, challenges, and opportunities in structural biology	28
TRAPs: the ‘elevator-with-an-operator’ mechanism	27
Monitoring subcellular NADP redox state with NAPstar biosensors	26
Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	26
Computationally guided AAV engineering for enhanced gene delivery	26
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	25
Wrapping up a special series on scientific figure development	25
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How to compile different types of structural visualizations in one panel	25
Lysines and cysteines: partners in stress?	25
SRC homology 3 domains: multifaceted binding modules	24
Protein SUMOylation and phase separation: partners in stress?	24
How integrin phosphorylations regulate cell adhesion and signaling	24
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	24
FN3K: the (un)sweetest kinase	24
Lipidation status of single membrane-associated ATG8 proteins	24
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	23
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	23
Oxytocin and vasopressin signaling in health and disease	22
Synaptoneurolipidomics: lipidomics in the study of synaptic function	22
Endogenous plant nitroxyl, a new component of nitric oxide biology	22
Discovering riboswitches: the past and the future	22
To Ub or not to Ub: a regulatory question in TGF-β signaling	22
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Advisory Board and Contents	21
Discordant skeletal muscle gene and protein responses to exercise	21
Protein Termini 2022: central roles of protein ends	21
Creating accessibility in academic negotiations	21
Biomolecules capturing live bacteria from clinical samples	20
Regulation of Autophagy Enzymes by Nutrient Signaling	20
Structural transitions modulate the chaperone activities of Grp94	20
Enlightening epigenetics: optochemical tools illuminate the path	20
Uncovering viral RNA–host cell interactions on a proteome-wide scale	20
Maximizing grant funding: strategies for negotiating laboratory pricing	20
Understanding the dynamic design of the spliceosome	20
Spray-type modifications: an emerging paradigm in post-translational modifications	20
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	20
Cytoplasmic gene expression: lessons from poxviruses	20
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	20
Using light to drive energy transduction in metazoan aging	19
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Advisory Board and Contents	19
Mitochondrial DNA: cellular genotoxic stress sentinel	19
More Than Just Closed and Open: Unraveling a Mechanosensor	19
A vigilant gliding bird protects plants	18
Take Your PIC	18
Advisory Board and Contents	18
Film-like organelles equip cells with multiple genetic codes	18
Advisory Board and Contents	18
Coupling lipid synthesis with nuclear envelope remodeling	18
Thermal proteome profiling of protein-centric interactions and modifications	17
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Substrate and phosphorylation site selection by phosphoprotein phosphatases	17
News about amino acid metabolism in plant–microbe interactions	17
Transforming eukaryotic cell culture with macromolecular crowding	17
Structural advances in sterol-sensing domain-containing proteins	17
The lysosome as a master regulator of iron metabolism	16
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Advisory Board and Contents	16
Mitochondria in disease: changes in shapes and dynamics	16
Advisory Board and Contents	16
Microtubule specialization by +TIP networks: from mechanisms to functional implications	15
Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy	15
Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design	15
Consequences of telomere replication failure: the other end-replication problem	15
The Retromer Complex: From Genesis to Revelations	15
Translational control through ribosome heterogeneity and functional specialization	15
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LncRNAs: the missing link to senescence nuclear architecture	14
More Than Just Letters and Chemistry: Genomics Goes Mechanics	14
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Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD+	14
How do plants feel the heat and survive?	14
Unlocking translational machinery for antitubercular drug development	14
Topological Twists in Nature	13
Mechanisms and rationales of SAM homeostasis	13
Giant variations in giant virus genome packaging	13
The metabolic cross-talk between cancer and T cells	13
The physiological relevance of autophagosome morphogenesis	13
The quest to identify ADP-ribosylation readers: methodological advances	13
Mitochondrial heat production: the elephant in the lab…	12
Confluence and convergence of Dscam and Pcdh cell-recognition codes	12
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?	12
Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells	12
The enzymes for genome size increase and maintenance of large (+)RNA viruses	12
Looking lively: emerging principles of pseudokinase signaling	11
Important questions and future directions in plant biochemistry	11
Mechanisms of Gβγ Release upon GPCR Activation	11
Advisory Board and Contents	11
Assembling the jigsaw puzzle of life	11
ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising	11
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions	11
Building a laboratory and networks during the COVID-19 pandemic	11
Two for one: regulatory RNAs that encode small proteins	10
Ensembles of synthetic polymers mimic biological fluids	10
Biogenesis and engineering of interleukin 12 family cytokines	10
Insights into mitoribosomal biogenesis from recent structural studies	10
Textbook oxidative phosphorylation needs to be rewritten	10
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain	10
Molecular determinants of protein evolvability	10
RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer	10
cAMP signaling: a remarkably regional affair	10
Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology	10
Back on the chain gang: polyphosphate modification of proteins	10
The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases	10
Trials and tribulations of statistical significance in biochemistry and omics	9
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Chemical genetic methodologies for identifying protein substrates of PARPs	9
Mapping histone modification-dependent protein interactions with chemical proteomics	9
Coenzyme Q biochemistry and biosynthesis	9
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Size does matter: piRNA and miRNA targeting	9
Microbial Prions: Dawn of a New Era	9
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	9
Structural Basis for the Modulation of Ryanodine Receptors	9
Creating overview and summary figures	9
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Contributions of single-particle cryoelectron microscopy toward fighting COVID-19	9
Mps1 kinase functions in mitotic spindle assembly and error correction	9
Frozen motion: how cryo-EM changes the way we look at ABC transporters	8
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	8
Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins	8
One Ring to Rule them All? Structural and Functional Diversity in the Nuclear Pore Complex	8
Understanding mitochondrial protein import: a revised model of the presequence translocase	8
Advisory Board and Contents	8
Advisory Board and Contents	8
Z-DNA at the crossroads: untangling its role in genome dynamics	8
Assembly and function of branched ubiquitin chains	8
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Characterizing Circular RNAs Using Nanopore Sequencing	8
Chemical probes for imaging cellular compartmentalization	8
The emerging roles of S-acylation in autophagy	7
Mammalian viral suppressors of RNA interference	7
Interplay of cGAS with chromatin	7
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Advisory Board and Contents	7
Machine learning and protein allostery	7
Structural basis of torque generation in the bi-directional bacterial flagellar motor	7
Detecting and Rescuing Stalled Ribosomes	7
BRCA1/BARD1 is a nucleosome reader and writer	7
PML isoforms: a molecular basis for PML pleiotropic functions	7
Endomembrane GPCR signaling: 15 years on, the quest continues	7
Beyond Autophagy: The Expanding Roles of ATG8 Proteins	7
Joan J. Guinovart (1947–2025)	7
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time	7
IUBMB Trainee Initiative: supporting emerging biochemists and molecular biologists around the world	6
How does p53 work? Regulation by the intrinsically disordered domains	6
Methods for the directed evolution of biomolecular interactions	6
mRNA accessibility within mRNPs as a determinant of gene expression	6
Advancing sustainable biotechnology through protein engineering	6
Broadening access to cryoEM through centralized facilities	6
Recent structural advances towards understanding of the bacterial type III secretion injectisome	6
Protein–membrane interactions: sensing and generating curvature	6
Recent and future perspectives on engineering interferons and other cytokines as therapeutics	5
DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles	5
ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease	5
Incorporating chemical structures into scientific figures	5
Interplay between the transcription preinitiation complex and the +1 nucleosome	5
ProP-PD for proteome-wide motif-mediated interaction discovery	5
Targeting the nucleolus as a therapeutic strategy in human disease	5
Advisory Board and Contents	5
Efficient PROTAC-ing: combinational use of PROTACs with signaling pathway inhibitors	5
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