Trends in Biochemical Sciences

Article	Citations
Biomolecular Condensates in the Nucleus	294
Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy	279
FUS and TDP-43 Phases in Health and Disease	170
The NLRP3 inflammasome: activation and regulation	145
Hippo Signaling in Embryogenesis and Development	143
Cell entry by SARS-CoV-2	128
Autophagy Assays for Biological Discovery and Therapeutic Development	123
G-Quadruplexes in RNA Biology: Recent Advances and Future Directions	119
Single-Cell Proteomics	112
Origins and evolving functionalities of tRNA-derived small RNAs	101
YAP and TAZ Are Not Identical Twins	100
The lysosome as a master regulator of iron metabolism	99
Coordinating gene expression during the cell cycle	98
Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels	97
Discovering riboswitches: the past and the future	94
How Lysosomes Sense, Integrate, and Cope with Stress	91
ADAR RNA Modifications, the Epitranscriptome and Innate Immunity	87
ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease	82
Extracellular miRNAs and Cell–Cell Communication: Problems and Prospects	81
Beyond Autophagy: The Expanding Roles of ATG8 Proteins	79
Mechanisms of Long Noncoding RNA Nuclear Retention	72
Circular RNAs in Immune Response and Viral Infection	70
One Ring to Rule them All? Structural and Functional Diversity in the Nuclear Pore Complex	70
Histone Tail Conformations: A Fuzzy Affair with DNA	69
Rapid Detection and Signaling of DNA Damage by PARP-1	68

The Retromer Complex: From Genesis to Revelations	68
Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications	67
Direct Structural Insights into GABAA Receptor Pharmacology	66
How do plants feel the heat and survive?	64
Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function	62
Biomolecular Condensates and Their Links to Cancer Progression	61
Translational control through ribosome heterogeneity and functional specialization	61
A Chain of Events: Regulating Target Proteins by SUMO Polymers	61
Molecular mechanisms of heat shock factor 1 regulation	60
Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation	59
Mitochondrial DNA: cellular genotoxic stress sentinel	58
News about amino acid metabolism in plant–microbe interactions	58
Regulation of Autophagy Enzymes by Nutrient Signaling	57
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	57
Molecular Determinants of Flavivirus Virion Assembly	54
Drug discovery in the era of cryo-electron microscopy	53
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	52
Detecting and Rescuing Stalled Ribosomes	51
Assembly and function of branched ubiquitin chains	51
Canary in a coal mine: collided ribosomes as sensors of cellular conditions	50
A Tour of TOR Complex Signaling in Plants	50
Revisiting Extracellular RNA Release, Processing, and Function	50
Nonredundant Roles of GRASP55 and GRASP65 in the Golgi Apparatus and Beyond	49
The Mediator kinase module: an interface between cell signaling and transcription	48
Therapeutic targeting of TEAD transcription factors in cancer	47
Divalent Cations: A Molecular Glue for Protein Materials	47
The Evolution of STING Signaling and Its Involvement in Cancer	45
Control of chloroplast degradation and cell death in response to stress	45
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?	45
The Integrator Complex in Transcription and Development	44
The Hammer and the Dance of Cell Cycle Control	44
Integrins Control Vesicular Trafficking; New Tricks for Old Dogs	43
Mitochondrial compartmentalization: emerging themes in structure and function	43
Spirits in the Material World: Enhancer RNAs in Transcriptional Regulation	43
DEAH-Box RNA Helicases in Pre-mRNA Splicing	43
Structural basis of torque generation in the bi-directional bacterial flagellar motor	42
Circular RNAs in physiology and non-immunological diseases	41
Coenzyme Q biochemistry and biosynthesis	41
Novel machine learning approaches revolutionize protein knowledge	39
A roadmap for rRNA folding and assembly during transcription	38
The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis	38
Big-Data Glycomics: Tools to Connect Glycan Biosynthesis to Extracellular Communication	38
Charting a DNA Repair Roadmap for Immunoglobulin Class Switch Recombination	38
Nucleic Acid-Based Technologies Targeting Coronaviruses	37
Methods to Study Phase-Separated Condensates and the Underlying Molecular Interactions	37
How integrin phosphorylations regulate cell adhesion and signaling	35
How Hierarchical Interactions Make Membraneless Organelles Tick Like Clockwork	35
Mentoring during Uncertain Times	35
Time to target the circadian clock for drug discovery	34
Plant biochemistry influences tropospheric ozone formation, destruction, deposition, and response	34

Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling	34
The many faces of RNA-based RNase P, an RNA-world relic	34
Interaction modules that impart specificity to disordered protein	34
Intrinsically disordered regions are poised to act as sensors of cellular chemistry	33
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	32
PI3K functions as a hub in mechanotransduction	32
Galvanization of Protein–Protein Interactions in a Dynamic Zinc Interactome	32
The broader sense of nonsense	31
N6-Methyladenosine Regulates Host Responses to Viral Infection	31
MicroRNA turnover: a tale of tailing, trimming, and targets	31
Advances in the World of Bacterial Microcompartments	30
Molecular Mechanisms of Lysosome and Nucleus Communication	30
Uncovering viral RNA–host cell interactions on a proteome-wide scale	30
The Life Cycle of the Mu-Opioid Receptor	30
Who let the DoGs out? – biogenesis of stress-induced readthrough transcripts	29
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	29
Cooperative assembly of the mitochondrial respiratory chain	29
Targeting the nucleolus as a therapeutic strategy in human disease	29
Coupling lipid synthesis with nuclear envelope remodeling	28
Proteasome substrate receptors and their therapeutic potential	28
Creating memories: molecular mechanisms of CRISPR adaptation	27
Ribosomal DNA and the nucleolus at the heart of aging	26
Non-enzymatic Covalent Modifications as a New Chapter in the Histone Code	26
Completing the canvas: advances and challenges for DNA-PAINT super-resolution imaging	26
Transforming eukaryotic cell culture with macromolecular crowding	26
To Ub or not to Ub: a regulatory question in TGF-β signaling	26
COVID-19 Vaccines Based on Adenovirus Vectors	25
Roles and dynamics of 3-methylcytidine in cellular RNAs	24
Integrating adipocyte insulin signaling and metabolism in the multi-omics era	24
SLC16 Family: From Atomic Structure to Human Disease	24
Nucleosomes Meet Their Remodeler Match	24
Structures, Mechanisms, and Functions of His-Me Finger Nucleases	24
Shedding Light on the Ghost Proteome	22
Membrane homeostasis beyond fluidity: control of membrane compressibility	22
Let’s phase it: viruses are master architects of biomolecular condensates	21
Exploiting enzyme evolution for computational protein design	21
Protein Amyloid Cofactors: Charged Side-Chain Arrays Meet Their Match?	21
Next-Generation Pathology by Multiplexed Immunohistochemistry	20
DNA Processing in the Context of Noncoding Transcription	20
Molecular Dynamics Simulations of Ion Channels	20
NAADP-binding proteins find their identity	19
On the Cutting Edge: Regulation and Therapeutic Potential of the mRNA 3′ End Nuclease	19
Advances in computational methods for ligand binding kinetics	19
Balancing the Opposing Principles That Govern Peroxisome Homeostasis	18
Targeting SLC transporters: small molecules as modulators and therapeutic opportunities	18
Interplay of cGAS with chromatin	18
A NuRD for all seasons	18
NLR signaling in plants: from resistosomes to second messengers	18
Mammalian viral suppressors of RNA interference	18
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	18
Mitochondria in disease: changes in shapes and dynamics	18
Recent advances in predicting and modeling protein–protein interactions	18
Seeing Atoms by Single-Particle Cryo-EM	18
Unconventional secretion mediated by direct protein self-translocation across the plasma membranes of mammalian cells	17
Causes and consequences of DNA single-strand breaks	17
The space between notes: emerging roles for translationally silent ribosomes	17
Consequences of telomere replication failure: the other end-replication problem	17
Lamin post-translational modifications: emerging toggles of nuclear organization and function	17
Determining and interpreting protein lifetimes in mammalian tissues	17
Looking lively: emerging principles of pseudokinase signaling	16
Seeing the forest through the trees: characterizing the glycoproteome	16
Chaperoning shape-shifting tau in disease	16
Crowding revisited: Open questions and future perspectives	16
Diverse heterochromatin states restricting cell identity and reprogramming	16
Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine	16
Structural advances in sterol-sensing domain-containing proteins	16
NAD-capped RNAs – a redox cofactor meets RNA	16
BRCA1/BARD1 is a nucleosome reader and writer	15
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	15
Cryo-electron tomography of enveloped viruses	15
A Role for N6-Methyladenine in DNA Damage Repair	15
Deconstructing the transmembrane core of class A G protein–coupled receptors	15
Transporter Specificity: A Tale of Loosened Elevator-Sliding	15
H2A.Z's ‘social’ network: functional partners of an enigmatic histone variant	15
Time management for STEMM students during the continuing pandemic	15
The spindle checkpoint proteins BUB1 and BUBR1: (SLiM)ming down to the basics	15
SRC homology 3 domains: multifaceted binding modules	15
Beyond the marks: reader-effectors as drivers of epigenetics and chromatin engineering	15
The enzymes for genome size increase and maintenance of large (+)RNA viruses	14
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	14

DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles	14
Microbial Prions: Dawn of a New Era	14
Molecular determinants of protein evolvability	13
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	13
Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy	13
UFMylation: a ubiquitin-like modification	13
Phase separation enhances probability of receptor signalling and drug targeting	13
Substrate and phosphorylation site selection by phosphoprotein phosphatases	13
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	13
The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases	12
Mechanistic insights into the versatile class II CRISPR toolbox	12
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	12
PML isoforms: a molecular basis for PML pleiotropic functions	12
Insights into mitoribosomal biogenesis from recent structural studies	12
Controlling the Controllers: Regulation of Histone Methylation by Phosphosignalling	12
ProP-PD for proteome-wide motif-mediated interaction discovery	12
Protein kinase C: release from quarantine by mTORC2	12
Activity-based annotation: the emergence of systems biochemistry	12
Redox Biochemistry of the Genetic Code	12
Broadening access to cryoEM through centralized facilities	12
Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology	11
Revisiting focused ion beam scanning electron microscopy	11
Biogenesis and engineering of interleukin 12 family cytokines	11
Ultrahigh-throughput screening in microfluidic droplets: a faster route to new enzymes	11
Cytoplasmic gene expression: lessons from poxviruses	11
Structural view of G protein-coupled receptor signaling in the retinal rod outer segment	11
Is a cure for Parkinson’s disease hiding inside us?	10
Advances and challenges in identifying and characterizing G-quadruplex–protein interactions	10
Protein SUMOylation and phase separation: partners in stress?	10
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions	10
Gas regulation of complex II reversal via electron shunting to fumarate in the mammalian ETC	10
Frozen motion: how cryo-EM changes the way we look at ABC transporters	10
Transcriptional lockdown during acute proteotoxic stress	10
Recent and future perspectives on engineering interferons and other cytokines as therapeutics	10
Structural Basis for the Modulation of Ryanodine Receptors	10
Chemical genetic methodologies for identifying protein substrates of PARPs	10
7TM domain structures of adhesion GPCRs: what's new and what's missing?	9
Transcription-coupled nucleosome assembly	9
Characterizing Circular RNAs Using Nanopore Sequencing	9
Roc, the G-domain of the Parkinson’s disease-associated protein LRRK2	9
Convergent evolution in two bacterial replicative helicase loaders	9
Recent structural advances towards understanding of the bacterial type III secretion injectisome	9
cCMP and cUMP come into the spotlight, finally	9
Discovery, biochemical characterization, and bioengineering of cyanobactin prenyltransferases	9
Reciprocal Links between Pre-messenger RNA 3′-End Processing and Genome Stability	9
Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes	9
Exploring membrane asymmetry and its effects on membrane proteins	9
Transcription-coupled global genomic repair in E. coli	9
Correlative light-electron microscopy: integrating dynamics to structure	9
Native-like environments afford novel mechanistic insights into membrane proteins	9
Jekyll and Hyde: Activating the Hypoxic Translational Machinery	8
Roles of zinc-binding domain of bacterial RNA polymerase in transcription	8
The Trinity of SPRTN Protease Regulation	8
Substrate recognition and transport mechanism of the PIN-FORMED auxin exporters	8
Digest it all: the lysosomal turnover of cytoplasmic aggregates	8
Non-histone binding functions of PHD fingers	8
Epigenetic and transcription factors synergistically promote the high temperature response in plants	8
Contributions of single-particle cryoelectron microscopy toward fighting COVID-19	8
NCBP3: A Multifaceted Adaptive Regulator of Gene Expression	8
Inheritance of Histone (H3/H4): A Binary Choice?	8
How NS1 Antibodies Prevent Severe Flavivirus Disease	8
Through the looking glass: milestones on the road towards mirroring life	8
Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases	7
Functional modulation of chemical mediators in microbial communities	7
Machine learning and protein allostery	7
Type III CRISPR-Cas: beyond the Cas10 effector complex	7
Microtubule nucleation for spindle assembly: one molecule at a time	7
Discordant skeletal muscle gene and protein responses to exercise	7
The twisted path of the 3D genome: where does it lead?	7
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	7
Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD+	6
Membrane protein synthesis: no cells required	6
Mechanistic perspectives on anti-aminoacyl-tRNA synthetase syndrome	6
Interpreting metabolic complexity via isotope-assisted metabolic flux analysis	6
TCA cycle off, ATF4 on for metabolic homeostasis	6
Does chromatin function as a metabolite reservoir?	6
A new path for terpenoid biosynthesis	6
RNA levers and switches controlling viral gene expression	6
cAMP signaling: a remarkably regional affair	5
Topological Twists in Nature	5
TrkB transmembrane domain: bridging structural understanding with therapeutic strategy	5
Activation, decommissioning, and dememorization: enhancers in a life cycle	5
Ancestral sequence reconstruction for evolutionary characterization of proteins	5
Tudor–dimethylarginine interactions: the condensed version	5
Why U matters: detection and functions of pseudouridine modifications in mRNAs	5
Structural parasitology of the malaria parasite Plasmodium falciparum	5
Direct assessment of histone function using histone replacement	5
Actin finally matures: uncovering machinery and impact	5
Methods for the directed evolution of biomolecular interactions	5
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	5
PAT in the ER for Transmembrane Protein Folding	4
High-throughput approaches to understand and engineer bacteriophages	4
Size does matter: piRNA and miRNA targeting	4
Plant-based carboxysomes: another step toward increased crop yields	4
DNA segregation in mitochondria and beyond: insights from the trypanosomal tripartite attachment complex	4