Trends in Cell Biology

Article	Citations
Emerging Mechanisms and Disease Relevance of Ferroptosis	605
EMT, MET, Plasticity, and Tumor Metastasis	486
Lipid Rafts: Controversies Resolved, Mysteries Remain	367
The Complex Interplay between Antioxidants and ROS in Cancer	340
Tight Junction Structure and Function Revisited	304
The Roles of CD8+ T Cell Subsets in Antitumor Immunity	251
Cytoskeletal Crosstalk in Cell Migration	227
Mitochondrial Functions in Infection and Immunity	207
Lipid Metabolism in Regulation of Macrophage Functions	198
Mitochondrial Fusion: The Machineries In and Out	169
ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum	167
p53 and Tumor Suppression: It Takes a Network	152
Conformational Basis of G Protein-Coupled Receptor Signaling Versatility	146
Polyploidy: A Biological Force From Cells to Ecosystems	137
A Senescence-Centric View of Aging: Implications for Longevity and Disease	137
Folding the Mitochondrial UPR into the Integrated Stress Response	134
Cell cycle on the crossroad of tumorigenesis and cancer therapy	129
Actin Cell Cortex: Structure and Molecular Organization	111
Classical and Nonclassical Intercellular Communication in Senescence and Ageing	109
Extracellular vesicles and nanoparticles: emerging complexities	100
All Roads Lead to Directional Cell Migration	98
Cholesterol Handling in Lysosomes and Beyond	96
Cell biology of inflammasome activation	91
Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation	90
Lipid Droplet Contact Sites in Health and Disease	89

Extracellular Vesicle-Associated Proteins in Tissue Repair	89
Lipid Droplet Nucleation	87
Cristae Membrane Dynamics – A Paradigm Change	85
Cell Plasticity in Liver Regeneration	83
Transcription Factors and DNA Play Hide and Seek	81
Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins	77
Cardiolipin in Immune Signaling and Cell Death	75
Nucleation, stabilization, and disassembly of branched actin networks	75
Mechanical Regulation of Transcription: Recent Advances	75
Actin on and around the Nucleus	73
Nitrogen Metabolism in Cancer and Immunity	71
Endoplasmic Reticulum (ER) Stress Response Failure in Diseases	70
The amoeboid state as part of the epithelial-to-mesenchymal transition programme	70
Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity	69
The heterogeneity of cellular senescence: insights at the single-cell level	69
Noncanonical Cell Fate Regulation by Bcl-2 Proteins	68
Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease	68
The Ways of Actin: Why Tunneling Nanotubes Are Unique Cell Protrusions	67
Principles of Leukocyte Migration Strategies	66
Mechanical communication in fibrosis progression	64
3D gastruloids: a novel frontier in stem cell-based in vitro modeling of mammalian gastrulation	64
The dark proteome: translation from noncanonical open reading frames	62
Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases	62
Phase separation in genome organization across evolution	60
DNA single-strand break repair and human genetic disease	59
New Insights into CDK Regulators: Novel Opportunities for Cancer Therapy	57
Heterogeneity in mRNA Translation	55
Dynamic Plasma Membrane Organization: A Complex Symphony	54
Mitotic disassembly and reassembly of nuclear pore complexes	54
Cyclin E in normal physiology and disease states	53
Regulation and Consequences of cGAS Activation by Self-DNA	53
Peroxisomes as cellular adaptors to metabolic and environmental stress	52
When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response	52
Expanding the View of IKK: New Substrates and New Biology	52
Cell–3D matrix interactions: recent advances and opportunities	52
Cutting, Amplifying, and Aligning Microtubules with Severing Enzymes	51
A Dynamical Paradigm for Molecular Cell Biology	51
Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation	50
CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator	49
Photoreceptor Discs: Built Like Ectosomes	49
LncRNAs in human cancers: signal from noise	48
Membrane Protein Quality Control Mechanisms in the Endo-Lysosome System	48
Tau liquid–liquid phase separation in neurodegenerative diseases	48
Translocation of Proteins through a Distorted Lipid Bilayer	47
Transcription-Coupled DNA Repair: From Mechanism to Human Disorder	47
Cellular functions of cGAS-STING signaling	47
Quantitative Data Analysis in Single-Molecule Localization Microscopy	46
Golgi Apparatus: An Emerging Platform for Innate Immunity	45
Principles of membrane remodeling by dynamic ESCRT-III polymers	44
A novel superfamily of bridge-like lipid transfer proteins	44

Circadian regulation of cancer cell and tumor microenvironment crosstalk	43
Sirtuin 6: linking longevity with genome and epigenome stability	43
Prime Editing: A New Way for Genome Editing	43
Connecting the Dots: Linking Caenorhabditis elegans Small RNA Pathways and Germ Granules	43
Metabolic Regulation of Tissue Stem Cells	42
Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications	42
Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin	42
Non-canonical mTORC1 signaling at the lysosome	42
Transsulfuration, minor player or crucial for cysteine homeostasis in cancer	41
Phase Separation during Germline Development	41
Turning the Oxygen Dial: Balancing the Highs and Lows	40
Primary ciliary signaling: links with the cell cycle	40
Regulation of gene expression by glycolytic and gluconeogenic enzymes	40
Golgi Outposts Nucleate Microtubules in Cells with Specialized Shapes	38
The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development	37
The Complex Dance of Organelles during Mitochondrial Division	37
Chromatin mobility and relocation in DNA repair	36
Human embryonic development: from peri-implantation to gastrulation	35
Controlling Cell Death through Post-translational Modifications of DED Proteins	34
The Endothelium: An Active Regulator of Lipid and Glucose Homeostasis	34
DNA replication: the recombination connection	34
MYC: a complex problem	33
The elegant complexity of mammalian ecto-5′-nucleotidase (CD73)	32
Nucleus segmentation: towards automated solutions	32
Muscle Stem Cell Quiescence: Controlling Stemness by Staying Asleep	32
Quality control of protein complex assembly by the ubiquitin–proteasome system	31
CDK1, the Other ‘Master Regulator’ of Autophagy	31
Mitochondrial regulation and white adipose tissue homeostasis	31
Getting into Position: Nuclear Movement in Muscle Cells	31
Long Noncoding RNAs in Human Stemness and Differentiation	30
Viewing Nuclear Architecture through the Eyes of Nocturnal Mammals	30
Structural Insights into STING Signaling	30
A Condensed View of the Chromosome Passenger Complex	30
Differentiation of the tumor microenvironment: are CAFs the Organizer?	30
Role of N7-methylguanosine (m7G) in cancer	30
Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia	29
J-domain protein chaperone circuits in proteostasis and disease	29
Regulation of ferroptosis by lipid metabolism	29
Fueling Cell Invasion through Extracellular Matrix	29
Chromatin basis of the senescence-associated secretory phenotype	28
Building GLUT4 Vesicles: CHC22 Clathrin’s Human Touch	28
A New Paradigm in Catalase Research	28
Roles of YAP/TAZ in ferroptosis	27
A long look at short prokaryotic Argonautes	27
Emerging roles of peroxisomes in viral infections	27
REV7: Jack of many trades	26
CRL4Cdt2: Coupling Genome Stability to Ubiquitination	26
Insights into peptidylarginine deiminase expression and citrullination pathways	26
Rigidity transitions in development and disease	25
Built to last: lysosome remodeling and repair in health and disease	25
Mechanisms of cellular mRNA transcript homeostasis	25
Mechanisms Linking Mitochondrial Dysfunction and Proteostasis Failure	25
Physics of liquid crystals in cell biology	25
Phenotypic plasticity during metastatic colonization	24
Role of GTPases in Driving Mitoribosome Assembly	23
REV7 directs DNA repair pathway choice	23
Chromatin Tracing: Imaging 3D Genome and Nucleome	23
Mitochondrial DNA Dynamics in Reprogramming to Pluripotency	23
Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells	23
Structure-Mediated Degradation of CircRNAs	23
Targeting STING to promote antitumor immunity	22
A glitch in the matrix: organ-specific matrisomes in metastatic niches	22
Histone Variants and Histone Modifications in Neurogenesis	22
The autophagy–NAD axis in longevity and disease	22
Tight Junction Structure and Function Revisited	21
Global miRNA to miRNA Interactions: Impacts for miR-21	21
The Warburg effect: a signature of mitochondrial overload	21
Cohesin: behind dynamic genome topology and gene expression reprogramming	21
Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity	20
Interphase microtubules in nuclear organization and genome maintenance	20
Stress relief: emerging methods to mitigate dissociation-induced artefacts	20
Shared genetic and epigenetic changes link aging and cancer	20
Capturing cancer evolution using genetically engineered mouse models (GEMMs)	20
Lysosomal quality control: molecular mechanisms and therapeutic implications	20
Ferroptosis: mechanisms and implications for cancer development and therapy response	20
Seipin: harvesting fat and keeping adipocytes healthy	20
Cut loose TIMP-1: an emerging cytokine in inflammation	20
Primordial super-enhancers: heat shock-induced chromatin organization in yeast	19
Targeting ferroptosis to treat colorectal cancer	19
Solute carrier transporters: emerging central players in tumour immunotherapy	19

Protein Sorting within Chloroplasts	18
Adherens junction: the ensemble of specialized cadherin clusters	18
Kinase regulation by liquid–liquid phase separation	18
Extracellular matrix remodeling facilitates obesity-associated cancer progression	18
The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome	18
Ectopic biomolecular phase transitions: fusion proteins in cancer pathologies	18
Cellular Senescence Variation by Metabolic and Epigenomic Remodeling	18
Mechanical regulation of cell-cycle progression and division	18
The web of death: the expanding complexity of necroptotic signaling	18
Fracture in living tissues	18
Cellular mechanisms of connexin-based inherited diseases	18
Caspase-2 as a master regulator of genomic stability	17
Programmed Cell Death: Central Player in Fungal Infections	17
Agent-based methods facilitate integrative science in cancer	17
The enigmatic roles of epithelial gasdermin B: Recent discoveries and controversies	17
The two sides of creatine in cancer	17
Time to eat reveals the hierarchy of peripheral clocks	16
Emerging roles of intratumor microbiota in cancer metastasis	16
Degradation of nuclear components via different autophagy pathways	16
Nucleolin: a binding partner of G-quadruplex structures	16
Regulation of nucleotide metabolism in cancers and immune disorders	16
The emergence of the stem cell niche	16
Polycomb repressive complex 2 in the driver’s seat of childhood and young adult brain tumours	16
Ubiquitylation at Stressed Replication Forks: Mechanisms and Functions	16
The state of F-BAR domains as membrane-bound oligomeric platforms	16
Protecting the future: balancing proteostasis for reproduction	16
Cancer Physical Hallmarks as New Targets for Improved Immunotherapy	16
Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks	15
Deep learning in image-based phenotypic drug discovery	15
Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints	15
GABAergic signaling beyond synapses: an emerging target for cancer therapy	15
The adipocyte supersystem of insulin and cAMP signaling	15
Coordination between Transport and Local Translation in Neurons	15
Membrane Architecture in the Spotlight of Correlative Microscopy	15
A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy	15
Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer	15
The peroxisome: an up-and-coming organelle in immunometabolism	15
mRNA Transport and Local Translation in Glia	15
Spatial regulation of microtubule-dependent transport by septin GTPases	15
Chaperone networks are shaped by cellular differentiation and identity	14
Plasticity of cancer invasion and energy metabolism	14
The ciliary impact of nonciliary gene mutations	14
Delta and epsilon tubulin in mammalian development	14
Changing places: Chromosomal Passenger Complex relocation in early anaphase	14
Internalized Activation of Membrane Receptors: From Phenomenon to Theory	14
E2 enzymes in genome stability: pulling the strings behind the scenes	14
Rewiring cell signalling pathways in pathogenic mtDNA mutations	14
Mitochondrial Functions in Infection and Immunity	13
The ins-and-outs of exosome biogenesis, secretion, and internalization	13
Modulation of membrane–cytoskeleton interactions: ezrin as key player	13
Harnessing orthogonal recombinases to decipher cell fate with enhanced precision	13
PhotoPROTACs: A Novel Biotechnology for Cancer Treatment	13
Transmembrane dislocases: a second chance for protein targeting	13
Nutrient availability as an arbiter of cell size	13
Disulfidptosis: disulfide stress–induced cell death	12
The Role of Organelles in Intestinal Function, Physiology, and Disease	12
Getting sharper: the brain under the spotlight of super-resolution microscopy	12
Chromatin dynamics in human brain development and disease	12
3′UTR heterogeneity and cancer progression	12
Is euchromatin really open in the cell?	12
Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila	12
Fukutin-Related Protein: From Pathology to Treatments	11
Metabolic Regulation of Intestinal Stem Cell Homeostasis	11
Moonlighting translation factors: multifunctionality drives diverse gene regulation	11
The role of RAS oncogenes in controlling epithelial mechanics	11
Intravital and high-content multiplex imaging of the immune system	11
Metabo-reciprocity in cell mechanics: feeling the demands/feeding the demand	11
Biomolecular Condensates at the Front: Cell Migration Meets Phase Separation	11
Cell Migration Guided by Cell–Cell Contacts in Innate Immunity	11
Wnt signalling in cell division: from mechanisms to tissue engineering	11
Steering yourself by the bootstraps: how cells create their own gradients for chemotaxis	10
Microbial metabolites: novel therapeutic tools for boosting cancer therapies	10
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity	10
Where protein structure and cell diversity meet	10
Stem cells at odds with telomere maintenance and protection	10
Nuclear pore complex maintenance and implications for age-related diseases	10
Elimination of Senescent Endothelial Cells: Good or Bad Idea?	9
Integrating mechanical signals into cellular identity	9
The Cys/N-degron pathway in the ubiquitin–proteasome system and autophagy	9
Membrane curvature as a signal to ensure robustness of diverse cellular processes	9
Mesenchymal Niches for Digestive Organ Development, Homeostasis, and Disease	9
Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis	9
Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis	9
The transcription factor code: a beacon for histone methyltransferase docking	9
Autophagy and pluripotency: self-eating your way to eternal youth	9
Multifaceted mitochondrial quality control in brown adipose tissue	9
Optical tweezers across scales in cell biology	9
Extracellular Vesicles: New Bullets to Fight Fungal Infections	8
Mitochondria in cancer: clean windmills or stressed tinkerers?	8
Glucose metabolism of TAMs in tumor chemoresistance and metastasis	8
Investigating Cellular Recognition Using CRISPR/Cas9 Genetic Screening	8
Bucket lists must be completed during cell death	8
How it feels in a cell	8
Okazaki fragment maturation: DNA flap dynamics for cell proliferation and survival	8
Beyond keratinocyte differentiation: emerging new biology of small proline-rich proteins	8