Trends in Cell Biology

Article	Citations
Advisory Board and Contents	521
Centrosomes and cancer: balancing tumor-promoting and inhibitory roles	395
Translation is an emerging constraint on protein homeostasis in ageing	308
HELLS: the transcriptional sentinel	301
Understanding human embryogenesis by building programmable stem cell-based models	250
Unlocking Latin America´s scientific potential: challenges and opportunities in a globalized world	231
DNA-PKcs kinase activity orchestrates both end-processing and end-ligation	228
The bidirectional relationship between metabolism and cell cycle control	186
An ATM D-compartmentalization in DNA damage response	175
Modulating cell-free DNA biology as the next frontier in liquid biopsies	169
The postdoctoral blueprint part one: creating a niche	163
(Alternative) transcription start sites as regulators of RNA processing	162
Plasticity of cancer invasion and energy metabolism	158
Optical tweezers across scales in cell biology	154
Cytoplasmic mtDNA clearance suppresses inflammatory immune responses	152
Regulation of lipid droplet dynamics and lipid homeostasis by hydroxysteroid dehydrogenase proteins	138
Subscription and Copyright Information	128
Olfaction: an emerging regulator of longevity and metabolism	124
Advisory Board and Contents	122
Where protein structure and cell diversity meet	116
Subscription and Copyright Information	116
What makes genes burst	111
Bucket lists must be completed during cell death	110
Membrane curvature at the ER–PM contact sites	109
A glitch in the matrix: organ-specific matrisomes in metastatic niches	108

The multifaceted mitochondrial OXA insertase	103
Lessons in longevity from blood stem cells under protein stress	102
Opportunities and challenges for deep learning in cell dynamics research	102
Optimality as a framework for understanding developmental robustness	91
The promiscuous ribosomal P-stalk: a new functional portrait	88
POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer	85
Progress and limitations in engineering cellular adhesion for research and therapeutics	81
The emergence of the stem cell niche	80
Deciphering the significance of p53 mutant proteins	79
DDX47 untangles R-loops with only certain other helicases	78
tRNA modifications: insights into their role in human cancers	77
Subscription and Copyright Information	77
Bioelectric regulation of intestinal stem cells	76
Cultured meat: creative solutions for a cell biological problem	75
Multifaceted mitochondrial quality control in brown adipose tissue	74
Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import	74
Visualizing intracellular target antigens in live cells	73
Sublethal engagement of apoptotic pathways in residual cancer	73
Advisory Board and Contents	72
Reimagining journal clubs for inclusive scientific training	71
Moonlighting translation factors: multifunctionality drives diverse gene regulation	69
Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy	68
Reprogramming transcription after DNA damage: recognition, response, repair, and restart	68
Tumor–stromal metabolic crosstalk in pancreatic cancer	67
Mitochondrial transfer at the crossroads of cancer, stromal, and immune cells	67
Built to last: lysosome remodeling and repair in health and disease	67
Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer	65
Self-inflicted DNA breaks in cell differentiation and cancer	65
Wnt signalling in cell division: from mechanisms to tissue engineering	65
Accessible high-speed image-activated cell sorting	61
Fun in the sun: ribosomes defend against UV irradiation	60
Shared genetic and epigenetic changes link aging and cancer	60
Unique architectural features of mammalian mitochondrial protein synthesis	59
Advisory Board and Contents	59
ERMCS Ca2+ transmission fuels cell division	58
Advisory Board and Contents	57
Transcription-coupled repair of DNA–protein crosslinks	56
Advisory Board and Contents	56
Membrane remodeling and trafficking piloted by SARS-CoV-2	56
Advisory Board and Contents	56
Embryos burn fat in standby	56
Subscription and Copyright Information	54
Young researchers series #7	54
Young researchers series #3	53
Young researchers series #3	52
Revealing new biology from multiplexed, metal-isotope-tagged, single-cell readouts	52
Thermoporter: a new regulatory mechanism for mitochondrial calcium uniporter activity	51
Meiotic spindle pushed outward by inward organelle packing	50
Targeting SHP1 and SHP2 to suppress tumors and enhance immunosurveillance	50
Filopodia: integrating cellular functions with theoretical models	49

Telomere dynamics as mediators of gut microbiota–host interactions	49
Differentiation of the tumor microenvironment: are CAFs the Organizer?	49
Intravital and high-content multiplex imaging of the immune system	48
Mechanical communication in fibrosis progression	48
Advisory Board and Contents	47
Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia	47
Advisory Board and Contents	46
Putative homeostatic role of cancer driver mutations	45
Orientational cell adhesions (OCAs) for tissue morphogenesis	43
Subscription and Copyright Information	43
Oxidative DNA damage and repair at non-coding regulatory regions	42
Order from chaos: cellular asymmetries explained with modelling	42
Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation	42
ER: a critical hub for STING signaling regulation	41
The idiosyncrasies of oocytes	40
Cell cycle regulation by the ribotoxic stress response	39
Modulation of membrane–cytoskeleton interactions: ezrin as key player	39
Chaperone networks are shaped by cellular differentiation and identity	39
Versatility of gasdermin D beyond pyroptosis	38
Young researchers series #6	38
Bloodhounds chasing the origin of blood cells	38
Disruption of lineage integrity as a precursor to breast tumor initiation	38
Cellular mechanics during division of a genomically minimal cell	38
Phase separation on microtubules: from droplet formation to cellular function?	38
Mechanical regulation of cell-cycle progression and division	37
The amoeboid state as part of the epithelial-to-mesenchymal transition programme	37
Regulation of gene expression by glycolytic and gluconeogenic enzymes	37
Sugar symphony: glycosylation in cancer metabolism and stemness	37
Lysosomal enzyme trafficking: from molecular mechanisms to human diseases	36
Patterns in the tapestry of chromatin-bound RB	36
Subscription and Copyright Information	36
Subscription and Copyright Information	35
Creating inclusive environments in cell biology by casual mentoring	35
New job for an old tool: PI3Kβ phosphorylates OGT to regulate acetyl-CoA in glioblastoma	34
Subscription and Copyright Information	33
Advisory Board and Contents	33
The neuronal-like behaviour of macrophages	33
Immune surveillance of senescence: potential application to age-related diseases	33
Hidden protein functions and what they may teach us	32
Subscription and Copyright Information	32
Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis	32
Advisory Board and Contents	32
The peroxisome: an up-and-coming organelle in immunometabolism	31
The adipocyte supersystem of insulin and cAMP signaling	31
Death by ribosome	31
Spermidine – an old molecule with a new age-defying immune function	31
Extracellular vesicle-mediated crosstalk in tumor microenvironment dominates tumor fate	31
Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks	31
Changing the culture for the future: time to take brain drain in academics seriously	30
The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond	30
Advisory Board and Contents	29
Young researchers series #2	29
The Cys/N-degron pathway in the ubiquitin–proteasome system and autophagy	28
The epigenetic landscape of mesenchymal stem cell and extracellular vesicle therapy	28
Muscle is a stage, and cells and factors are merely players	28
CS proteins and ubiquitination: orchestrating DNA repair with transcription and cell division	28
Quality control of mitochondrial nucleoids	27
The ubiquitin–proteasome system links NADPH metabolism to ferroptosis	26
Stress-induced cell depolarization through the MAP kinase–Cdc42 axis	26
Subscription and Copyright Information	26
Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications	26
Regulated circRNA nuclear export in neuronal differentiation	26
ER remodeling via lipid metabolism	26
Advisory Board and Contents	26
Advisory Board and Contents	25
Advisory Board and Contents	25
Subscription and Copyright Information	24
Metabolic regulation of mRNA splicing	24
Chromatin-interacting RNA-binding proteins regulate transcription	24
Molecular mechanisms of nucleolar DNA damage checkpoint response	24
Tumor-initiating cells establish a niche to overcome isolation stress	24
The Warburg effect: a signature of mitochondrial overload	23
Glucose metabolism of TAMs in tumor chemoresistance and metastasis	23
3′UTR heterogeneity and cancer progression	23
Emerging roles of intratumor microbiota in cancer metastasis	23
The heterogeneity of cellular senescence: insights at the single-cell level	22
A stable start: cotranslational Nt-acetylation promotes proteome stability across kingdoms	22
Subscription and Copyright Information	22
ATRX loss induces lineage plasticity and squamous-like phenotype to promote colorectal cancer metastasis	22
Phase separation of p62: roles and regulations in autophagy	22

Technological and computational advances driving high-throughput oncology	22
Decoding human cardiovascular development and disease through single-cell transcriptomic and epigenomic profiling	21
TFEB links the cGAS-STING pathway to lysosome biogenesis	21
Extracellular vesicles from the dead: the final message	21
Subscription and Copyright Information	20
Advisory Board and Contents	20
Subscription and Copyright Information	20
Hard to handle: how lipid saturation affects the nuclear envelope	20
Fumarate hydratase as a metabolic regulator of immunity	19
Time matters: the dynamics of plasma membrane repair	19
The two sides of creatine in cancer	19
Regulation of leukemogenesis via redox metabolism	19
Novel imaging methods and force probes for molecular mechanobiology of cytoskeleton and adhesion	19
Chromatin dynamics in human brain development and disease	19
RNA G-quadruplexes and stress: emerging mechanisms and functions	18
Fracture in living tissues	18
DNA single-strand break repair and human genetic disease	18
Multifaceted collagen-DDR1 signaling in cancer	18
The autophagy–NAD axis in longevity and disease	18
Nucleus segmentation: towards automated solutions	17
Celebrating 35 years of Trends in Cell Biology and introducing our special issue on ribosomal dynamics and cellular homeostasis	17
Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations	17
Subscription and Copyright Information	17
DNA replication: the recombination connection	17
Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production	17
The initiation of mammalian embryonic transcription: to begin at the beginning	16
Mechanism-aware and multimodal AI: beyond model-agnostic interpretation	16
Clonal hematopoiesis and inflammation – the perpetual cycle	16
Spotlighting adult stem cells: advances, pitfalls, and challenges	16
How pervasive are post-translational and -transcriptional modifications?	16
Ferroptosis: mechanisms and implications for cancer development and therapy response	16
Hypoxia-specific transcriptional condensates drive metastasis	16
The role of the immune tumor microenvironment in shaping metastatic dissemination, dormancy, and outgrowth	16
Implementing standardized diversity, equity, and inclusion approaches within scientific communities	15
Multiplicity of stem cell memories of inflammation and tissue repair in epithelia	15
The enigmatic roles of epithelial gasdermin B: Recent discoveries and controversies	15
Advisory Board and Contents	15
Unfolding by Cdc48/p97: different strokes for different folks	15
The role of RAS oncogenes in controlling epithelial mechanics	15
Reflected stemness as a potential driver of the tumour microenvironment	15
Degradation of nuclear components via different autophagy pathways	15
Mitochondrial substrate oxidation regulates distinct cell differentiation outcomes	15
Organelle-specific signaling of cGAS–STING	14
A novel superfamily of bridge-like lipid transfer proteins	14
Newly identified cell types crucial for gut commensal tolerance	14
Extracellular matrix remodeling facilitates obesity-associated cancer progression	14
Inter-membrane control of junctional InsP3 receptors by PIP2	14
Mechanisms of cellular mRNA transcript homeostasis	14
Cholesterol metabolism regulates macrophage function and inflammation-related diseases	13
PYK2, a hub of signaling networks in breast cancer progression	13
Coordinated in confined migration: crosstalk between the nucleus and ion channel-mediated mechanosensation	13
Subscription and Copyright Information	13
Experimental evolution for cell biology	13
Tau liquid–liquid phase separation in neurodegenerative diseases	13
3D genome folding in epigenetic regulation and cellular memory	13
Time as a danger signal promoting G1 arrest after mitosis	13
MDM4 exon skipping upon dysfunctional ribosome assembly	13
Roles of YAP/TAZ in ferroptosis	13
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective	13
CDK11, a splicing-associated kinase regulating gene expression	12
The cell biology of APOE in the brain	12
The culture and application of circulating tumor cell-derived organoids	12
Lysosomal microautophagy: an emerging dimension in mammalian autophagy	12
NADH reductive stress drives metabolic reprogramming	12
Vimentin at the core of wound healing	11
Triple threat: neutrophil ER stress, NETosis, airway inflammation escalation	11
Emerging roles of olfactory receptors in glucose metabolism	11
Plasma membrane damage is a new trigger of cellular senescence	11
Mechanobiology of organelles: illuminating their roles in mechanosensing and mechanotransduction	11
Advisory Board and Contents	11
Experimental tools and emerging principles of organellar mechanotransduction	11
miRNA dosage control in development and human disease	11
Is clathrin a membrane fission protein?	11
Metabolic and epigenetic regulation of endoderm differentiation	11
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity	11
Central role of the ER proteostasis network in healthy aging	10
The ins-and-outs of exosome biogenesis, secretion, and internalization	10
Human embryonic development: from peri-implantation to gastrulation	10
Metabolism and HSC fate: what NADPH is made for	10
Cell cycle on the crossroad of tumorigenesis and cancer therapy	10
How it feels in a cell	10
Metabolism and mRNA translation: a nexus of cancer plasticity	10
Navigating AKT-ivity across cellular compartments	10
Subscription and Copyright Information	10
Regulatory landscape of enhancer-mediated transcriptional activation	10
Autophagosomal components recycling on autolysosomes	10
Subscription and Copyright Information	10
Advisory Board and Contents	9
Advisory Board and Contents	9
Subscription and Copyright Information	9
The yin and yang of nuclear envelope breakdown through the activity of phosphatase holoenzyme PP2A-B55SUR-6	9
Nutrient availability as an arbiter of cell size	9
Advisory Board and Contents	9
Advisory Board and Contents	9
The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development	9