Trends in Cell Biology

Article	Citations
Lipid Metabolism in Regulation of Macrophage Functions	254
Mitochondrial Fusion: The Machineries In and Out	213
Extracellular vesicles and nanoparticles: emerging complexities	197
Cell cycle on the crossroad of tumorigenesis and cancer therapy	190
p53 and Tumor Suppression: It Takes a Network	179
The heterogeneity of cellular senescence: insights at the single-cell level	117
Lipid Droplet Contact Sites in Health and Disease	110
Lipid Droplet Nucleation	110
Extracellular Vesicle-Associated Proteins in Tissue Repair	106
Regulation of ferroptosis by lipid metabolism	105
All Roads Lead to Directional Cell Migration	105
Cell biology of inflammasome activation	104
Cristae Membrane Dynamics – A Paradigm Change	98
Cellular functions of cGAS-STING signaling	97
Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins	91
Actin on and around the Nucleus	90
The dark proteome: translation from noncanonical open reading frames	89
Mechanical communication in fibrosis progression	89
Mechanical Regulation of Transcription: Recent Advances	88
The amoeboid state as part of the epithelial-to-mesenchymal transition programme	87
Cardiolipin in Immune Signaling and Cell Death	87
Nucleation, stabilization, and disassembly of branched actin networks	86
Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity	84
The Ways of Actin: Why Tunneling Nanotubes Are Unique Cell Protrusions	82
Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications	79

Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease	78
Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases	78
DNA single-strand break repair and human genetic disease	78
Cell–3D matrix interactions: recent advances and opportunities	74
Tau liquid–liquid phase separation in neurodegenerative diseases	72
3D gastruloids: a novel frontier in stem cell-based in vitro modeling of mammalian gastrulation	72
New Insights into CDK Regulators: Novel Opportunities for Cancer Therapy	71
Expanding the View of IKK: New Substrates and New Biology	70
Peroxisomes as cellular adaptors to metabolic and environmental stress	69
Transcription-Coupled DNA Repair: From Mechanism to Human Disorder	68
Transsulfuration, minor player or crucial for cysteine homeostasis in cancer	68
Phase separation in genome organization across evolution	67
Regulation of gene expression by glycolytic and gluconeogenic enzymes	66
Photoreceptor Discs: Built Like Ectosomes	66
Cyclin E in normal physiology and disease states	65
Membrane Protein Quality Control Mechanisms in the Endo-Lysosome System	63
Mitotic disassembly and reassembly of nuclear pore complexes	63
Dynamic Plasma Membrane Organization: A Complex Symphony	63
Cutting, Amplifying, and Aligning Microtubules with Severing Enzymes	62
CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator	62
Non-canonical mTORC1 signaling at the lysosome	61
The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development	59
LncRNAs in human cancers: signal from noise	59
When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response	59
A novel superfamily of bridge-like lipid transfer proteins	59
Principles of membrane remodeling by dynamic ESCRT-III polymers	56
Circadian regulation of cancer cell and tumor microenvironment crosstalk	55
Translocation of Proteins through a Distorted Lipid Bilayer	55
MYC: a complex problem	52
Phase Separation during Germline Development	51
Connecting the Dots: Linking Caenorhabditis elegans Small RNA Pathways and Germ Granules	49
Human embryonic development: from peri-implantation to gastrulation	49
Quantitative Data Analysis in Single-Molecule Localization Microscopy	49
Sirtuin 6: linking longevity with genome and epigenome stability	49
Primary ciliary signaling: links with the cell cycle	48
The ins-and-outs of exosome biogenesis, secretion, and internalization	47
Mitochondrial regulation and white adipose tissue homeostasis	47
The Warburg effect: a signature of mitochondrial overload	45
Muscle Stem Cell Quiescence: Controlling Stemness by Staying Asleep	45
Targeting STING to promote antitumor immunity	44
DNA replication: the recombination connection	44
Chromatin basis of the senescence-associated secretory phenotype	44
Nucleus segmentation: towards automated solutions	43
Chromatin mobility and relocation in DNA repair	43
Quality control of protein complex assembly by the ubiquitin–proteasome system	43
Disulfidptosis: disulfide stress–induced cell death	43
A long look at short prokaryotic Argonautes	41
Insights into peptidylarginine deiminase expression and citrullination pathways	40
The Complex Dance of Organelles during Mitochondrial Division	40
Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia	40

The Endothelium: An Active Regulator of Lipid and Glucose Homeostasis	39
CDK1, the Other ‘Master Regulator’ of Autophagy	39
Role of N7-methylguanosine (m7G) in cancer	38
The peroxisome: an up-and-coming organelle in immunometabolism	38
The elegant complexity of mammalian ecto-5′-nucleotidase (CD73)	38
Targeting ferroptosis to treat colorectal cancer	38
Roles of YAP/TAZ in ferroptosis	37
Rigidity transitions in development and disease	37
Physics of liquid crystals in cell biology	36
Ferroptosis: mechanisms and implications for cancer development and therapy response	36
Differentiation of the tumor microenvironment: are CAFs the Organizer?	35
Mechanisms of cellular mRNA transcript homeostasis	34
J-domain protein chaperone circuits in proteostasis and disease	34
The emergence of the stem cell niche	33
Long Noncoding RNAs in Human Stemness and Differentiation	33
The autophagy–NAD axis in longevity and disease	33
Cohesin: behind dynamic genome topology and gene expression reprogramming	32
Fueling Cell Invasion through Extracellular Matrix	32
A New Paradigm in Catalase Research	31
Cut loose TIMP-1: an emerging cytokine in inflammation	31
The two sides of creatine in cancer	31
Lysosomal quality control: molecular mechanisms and therapeutic implications	31
Emerging roles of intratumor microbiota in cancer metastasis	31
Role of GTPases in Driving Mitoribosome Assembly	30
Built to last: lysosome remodeling and repair in health and disease	30
Emerging roles of peroxisomes in viral infections	30
REV7: Jack of many trades	30
Cellular mechanisms of connexin-based inherited diseases	29
Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells	29
Phenotypic plasticity during metastatic colonization	29
Molecular Evaluation of Endoplasmic Reticulum Homeostasis Meets Humoral Immunity	28
Tight Junction Structure and Function Revisited	28
Agent-based methods facilitate integrative science in cancer	28
Solute carrier transporters: emerging central players in tumour immunotherapy	28
Kinase regulation by liquid–liquid phase separation	28
Deep learning in image-based phenotypic drug discovery	27
Mechanical regulation of cell-cycle progression and division	27
Protecting the future: balancing proteostasis for reproduction	27
Shared genetic and epigenetic changes link aging and cancer	26
REV7 directs DNA repair pathway choice	26
Adherens junction: the ensemble of specialized cadherin clusters	25
Mitochondrial DNA Dynamics in Reprogramming to Pluripotency	25
Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila	25
Seipin: harvesting fat and keeping adipocytes healthy	25
Global miRNA to miRNA Interactions: Impacts for miR-21	25
Plasticity of cancer invasion and energy metabolism	25
Regulation of nucleotide metabolism in cancers and immune disorders	25
Stress relief: emerging methods to mitigate dissociation-induced artefacts	25
Pericytes in the disease spotlight	25
Interphase microtubules in nuclear organization and genome maintenance	24
Chromatin Tracing: Imaging 3D Genome and Nucleome	24
The enigmatic roles of epithelial gasdermin B: Recent discoveries and controversies	24
Is euchromatin really open in the cell?	24
The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome	24
Regulation of the length of neuronal primary cilia and its potential effects on signalling	23
Protein Sorting within Chloroplasts	23
Fracture in living tissues	23
Histone Variants and Histone Modifications in Neurogenesis	23
A glitch in the matrix: organ-specific matrisomes in metastatic niches	23
The web of death: the expanding complexity of necroptotic signaling	22
Spatial regulation of microtubule-dependent transport by septin GTPases	22
Primordial super-enhancers: heat shock-induced chromatin organization in yeast	22
Ferroptosis in mitochondrial cardiomyopathy	22
Caspase-2 as a master regulator of genomic stability	22
Capturing cancer evolution using genetically engineered mouse models (GEMMs)	22
Wnt signalling in cell division: from mechanisms to tissue engineering	21
GABAergic signaling beyond synapses: an emerging target for cancer therapy	21
The ciliary impact of nonciliary gene mutations	21
Cellular Senescence Variation by Metabolic and Epigenomic Remodeling	21
Degradation of nuclear components via different autophagy pathways	21
Programmed Cell Death: Central Player in Fungal Infections	21
The adipocyte supersystem of insulin and cAMP signaling	21
Extracellular matrix remodeling facilitates obesity-associated cancer progression	21
Ectopic biomolecular phase transitions: fusion proteins in cancer pathologies	20
Nucleolin: a binding partner of G-quadruplex structures	20
Ubiquitylation at Stressed Replication Forks: Mechanisms and Functions	19
3′UTR heterogeneity and cancer progression	19
Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer	19
Time to eat reveals the hierarchy of peripheral clocks	19
mRNA Transport and Local Translation in Glia	19

Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks	19
Glucose metabolism of TAMs in tumor chemoresistance and metastasis	19
Nutrient availability as an arbiter of cell size	19
Cancer Physical Hallmarks as New Targets for Improved Immunotherapy	19
Delta and epsilon tubulin in mammalian development	17
A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy	17
Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints	17
Multifaceted mitochondrial quality control in brown adipose tissue	17
The state of F-BAR domains as membrane-bound oligomeric platforms	17
Coordination between Transport and Local Translation in Neurons	17
The diverse nature of intestinal fibroblasts in development, homeostasis, and disease	16
E2 enzymes in genome stability: pulling the strings behind the scenes	16
Getting sharper: the brain under the spotlight of super-resolution microscopy	16
Intravital and high-content multiplex imaging of the immune system	16
The role of RAS oncogenes in controlling epithelial mechanics	16
Polycomb repressive complex 2 in the driver’s seat of childhood and young adult brain tumours	16
How it feels in a cell	16
Rewiring cell signalling pathways in pathogenic mtDNA mutations	16
Chaperone networks are shaped by cellular differentiation and identity	15
Okazaki fragment maturation: DNA flap dynamics for cell proliferation and survival	15
tRNA modifications: insights into their role in human cancers	15
Cell Migration Guided by Cell–Cell Contacts in Innate Immunity	15
NIPBL and cohesin: new take on a classic tale	15
miRNA dosage control in development and human disease	15
Modulation of membrane–cytoskeleton interactions: ezrin as key player	15
The Role of Organelles in Intestinal Function, Physiology, and Disease	15
Changing places: Chromosomal Passenger Complex relocation in early anaphase	15
Astrocyte morphology	14
Mitochondria in cancer stem cells: Achilles heel or hard armor	14
The Cys/N-degron pathway in the ubiquitin–proteasome system and autophagy	14
Clonal hematopoiesis and inflammation – the perpetual cycle	14
Metabolic Regulation of Intestinal Stem Cell Homeostasis	14
Mechanobiology of organelles: illuminating their roles in mechanosensing and mechanotransduction	14
Internalized Activation of Membrane Receptors: From Phenomenon to Theory	14
Harnessing orthogonal recombinases to decipher cell fate with enhanced precision	14
The multifaceted mitochondrial OXA insertase	13
Steering yourself by the bootstraps: how cells create their own gradients for chemotaxis	13
Moonlighting translation factors: multifunctionality drives diverse gene regulation	13
Membrane curvature as a signal to ensure robustness of diverse cellular processes	13
Integrating mechanical signals into cellular identity	13
Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis	13
The bidirectional relationship between metabolism and cell cycle control	13
Transmembrane dislocases: a second chance for protein targeting	13
Metabo-reciprocity in cell mechanics: feeling the demands/feeding the demand	13
Chromatin dynamics in human brain development and disease	12
The many faces of the helicase RTEL1 at telomeres and beyond	12
Fukutin-Related Protein: From Pathology to Treatments	12
Where protein structure and cell diversity meet	12
Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis	12
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity	12
Creating inclusive environments in cell biology by casual mentoring	12
Lysosomal enzyme trafficking: from molecular mechanisms to human diseases	12
The postdoctoral blueprint part two: the faculty application	12
Autophagy and pluripotency: self-eating your way to eternal youth	12
Microbial metabolites: novel therapeutic tools for boosting cancer therapies	12
Optical tweezers across scales in cell biology	12
Ubiquitination of non-protein substrates	11
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective	11
Contribution of metabolic abnormalities to acute myeloid leukemia pathogenesis	11
Tetraspanins: structure, dynamics, and principles of partner-protein recognition	11
Mitochondria in cancer: clean windmills or stressed tinkerers?	11
The transcription factor code: a beacon for histone methyltransferase docking	11
Nuclear pore complex maintenance and implications for age-related diseases	11
Biomolecular Condensates at the Front: Cell Migration Meets Phase Separation	11
Cep55: abscission boss or assistant?	10
Bucket lists must be completed during cell death	10
ΔNp63α in cancer: importance and therapeutic opportunities	10
The ubiquitin–proteasome system links NADPH metabolism to ferroptosis	10
The postdoctoral blueprint part one: creating a niche	10
Macroautophagy in quiescent and senescent cells: a pathway to longevity?	10
Stem cells at odds with telomere maintenance and protection	10
Muscle is a stage, and cells and factors are merely players	10
Beyond keratinocyte differentiation: emerging new biology of small proline-rich proteins	10
Elimination of Senescent Endothelial Cells: Good or Bad Idea?	10
Maintaining soluble protein homeostasis between nuclear and cytoplasmic compartments across mitosis	9
Inosine: novel activator of brown adipose tissue and energy homeostasis	9
Reflected stemness as a potential driver of the tumour microenvironment	9
Autophagy in intestinal epithelial cells prevents gut inflammation	9
Mesenchymal Niches for Digestive Organ Development, Homeostasis, and Disease	9
A new time dimension in the fight against metastasis	9
Phase separation on microtubules: from droplet formation to cellular function?	9
Cultured meat: creative solutions for a cell biological problem	9
Long-lived mitochondrial proteins and why they exist	9
Targeting of biomolecular condensates to the autophagy pathway	8
Molecular mechanisms of nucleolar DNA damage checkpoint response	8
Lysosomal microautophagy: an emerging dimension in mammalian autophagy	8
The initiation of mammalian embryonic transcription: to begin at the beginning	8
Tracking Mechanisms of Viral Dissemination In Vivo	8
Emerging roles of nuclear bodies in genome spatial organization	8
Cellular mechanics during division of a genomically minimal cell	8
Oxidative DNA damage and repair at non-coding regulatory regions	8
A stable start: cotranslational Nt-acetylation promotes proteome stability across kingdoms	8
Experimental manipulation of phosphoinositide lipids: from cells to organisms	8
Mechanobiological approaches to synthetic morphogenesis: learning by building	8
BRCA2 in mammalian meiosis	7