Statistical Methods in Medical Research

Article	Citations
Exact interval estimation for the linear combination of binomial proportions	121
Semiparametric copula method for semi-competing risks data subject to interval censoring and left truncation: Application to disability in elderly	71
A Bayesian beta-binomial piecewise growth mixture model for longitudinal overdispersed binomial data	61
Omnibus test for restricted mean survival time based on influence function	55
Interval estimation in three-class receiver operating characteristic analysis: A fairly general approach based on the empirical likelihood	33
Covariate adjustment in Bayesian adaptive randomized controlled trials	30
Confidence estimation based on data from independent studies	27
A new cure model accounting for longitudinal data and flexible patterns of hazard ratios over time	26
Time-varying coefficient additive hazards model with latent variables	26
Equivalence tests for ratio of means in bioequivalence studies under crossover design	25
Joint meta-analysis of two diagnostic tests accounting for within and between studies dependence	24
Commentary on the use of the reproduction number R during the COVID-19 pandemic	21
Analysis of hospital readmissions with competing risks	20
Challenges of modelling approaches for network meta-analysis of time-to-event outcomes in the presence of non-proportional hazards to aid decision making: Application to a melanoma network	19
Generalized Bayesian kernel machine regression	19
A competing risks model with binary time varying covariates for estimation of breast cancer risks in BRCA1 families	19
Accounting for informative observation process in transition models of binary longitudinal outcome: Application to medical record data	18
Generalised pairwise comparisons for trend: An extension to the win ratio and win odds for dose-response and prognostic variable analysis with arbitrary statements of outcome preference	18
Between-group comparison of area under the curve in clinical trials with censored follow-up: Application to HIV therapeutic vaccines	17
Mediational g-formula for time-varying treatment and repeated-measured multiple mediators: Application to atorvastatin’s effect on cardiovascular disease via cholesterol lowering and anti-inflammatory	16
Using shrinkage methods to estimate treatment effects in overlapping subgroups in randomized clinical trials with a time-to-event endpoint	16
Modeling and estimating a threshold effect: An application to improving cardiac surgery practices	16
A capture-recapture modeling framework emphasizing expert opinion in disease surveillance	15
Correlational analyses of biomarkers that are harmonized through a bridging study due to measurement errors	15
Revisiting performance metrics for prediction with rare outcomes	15

Developing clinical prediction models when adhering to minimum sample size recommendations: The importance of quantifying bootstrap variability in tuning parameters and predictive performance	13
Random survival forests with multivariate longitudinal endogenous covariates	12
Nonparametric analysis of doubly truncated and interval-censored data	12
Response-adaptive treatment randomization for multiple comparisons of treatments with recurrent event responses	12
Analyzing heterogeneity in biomarker discriminative performance through partial time-dependent receiver operating characteristic curve modeling	12
Multiplicative versus additive modelling of causal effects using instrumental variables for survival outcomes – a comparison	12
New clinical trial design borrowing information across patient subgroups based on fusion-penalized regression models	12
Augmenting contact matrices with time-use data for fine-grained intervention modelling of disease dynamics: A modelling analysis	11
On flexible inverse probability of treatment and intensity weighting: Informative censoring, variable selection, and weight trimming	11
Simultaneous confidence intervals for an extended Koch-Röhmel design in three-arm non-inferiority trials	11
Covariate selection for optimizing balance with an innovative adaptive randomization approach	11
A unified approach based on multidimensional scaling for calibration estimation in survey sampling with qualitative auxiliary information	10
Inference for the treatment effect in longitudinal cluster randomized trials when treatment effect heterogeneity is ignored	10
An iterative matrix uncertainty selector for high-dimensional generalized linear models with measurement errors	10
Fitting joint models of longitudinal observations and time to event by sequential Bayesian updating	9
Familywise error rate control for block response-adaptive randomization	9
Penalized variable selection in multi-parameter regression survival modeling	9
Modeling the patient mix for risk-adjusted CUSUM charts	9
Evaluating prognostic biomarkers for survival outcomes subject to informative censoring	9
A Bayesian genomic selection approach incorporating prior feature ordering and population structures with application to coronary artery disease	8
Modified Brier score for evaluating prediction accuracy for binary outcomes	8
Smoothing Lexis diagrams using kernel functions: A contemporary approach	8
A simple and robust parametric shared frailty model for recurrent events with the competing risk of death: An application to the Carvedilol Prospective Randomized Cumulative Survival trial	8
Inference on the overlap coefficient: The binormal approach and alternatives	8
Allowing for stratification in sample size planning of two-arm trials with continuous or binary outcome: Overview and tutorial	8
More efficient estimators of the area under the receiver operating characteristic curve in paired ranked set sampling	8
Unified exact design with early stopping rules for single arm clinical trials with multiple endpoints	8
Estimating a time-to-event distribution from right-truncated data in an epidemic: A review of methods	8
Quantifying proportion of treatment effect by surrogate endpoint under heterogeneity	8
General regression methods for respondent-driven sampling data	8
Adjusting for switches to multiple treatments: Should switches be handled separately or combined?	8
Improving the estimation of the COVID-19 effective reproduction number using nowcasting	8
Bayesian order constrained adaptive design for phase II clinical trials evaluating subgroup-specific treatment effect	8
The effect of estimating prevalences on the population-wise error rate	7
Causal simulation experiments: Lessons from bias amplification	7
Change plane model averaging for subgroup identification	7
Cause-specific hazard Cox models with partly interval censoring – Penalized likelihood estimation using Gaussian quadrature	7
Testing for marginal covariate effect when the subgroup size induced by the covariate is informative	7
Using horseshoe prior for incorporating multiple historical control data in randomized controlled trials	7
Model-based adaptive randomization procedures for heteroscedasticity of treatment responses	7
Review of sample size determination methods for the intraclass correlation coefficient in the one-way analysis of variance model	7
A semiparametric mixture model approach for regression analysis of partly interval-censored data with a cured subgroup	7
Regression analysis of multivariate recurrent event data allowing time-varying dependence with application to stroke registry data	7
A tight fit of the SIR dynamic epidemic model to daily cases of COVID-19 reported during the 2021–2022 Omicron surge in New York City: A novel approach	7
A generalization of moderated statistics to data adaptive semiparametric estimation in high-dimensional biology	7
Sample size calculation for multi-arm parallel design with restricted mean survival time	7
Complete effect decomposition for an arbitrary number of multiple ordered mediators with time-varying confounders: A method for generalized causal multi-mediation analysis	7
Estimation and inference on the partial volume under the receiver operating characteristic surface	7
Statistical methods for clinical trials interrupted by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic: A review	7
Fixed and random effect selections in generalized linear mixed models	6

Estimand-based inference in the presence of long-term survivors	6
Interval estimation for the Youden index of a continuous diagnostic test with verification biased data	6
Hunting for protective drugs at the break of a pandemic: Causal inference from hospital data	6
The analysis of COVID-19 in-hospital mortality: A competing risk approach or a cure model?	6
On recurrent-event win ratio	6
CFO: Calibration-free odds design for phase I/II clinical trials	6
Improved and computationally stable estimation of relative risk regression with one binary exposure	6
A competing risks regression model for the association between time-varying opioid exposure and risk of overdose	6
Test sensitivity in a prospective cancer screening program: A critique of a common proxy measure	6
qTPI: A quasi-toxicity probability interval design for phase I trials with multiple-grade toxicities	6
Flexible extension of the accelerated failure time model to account for nonlinear and time-dependent effects of covariates on the hazard	6
BOIN-ETC: A Bayesian optimal interval design considering efficacy and toxicity to identify the optimal dose combinations	6
Space-time interactions in Bayesian disease mapping with recent tools: Making things easier for practitioners	6
MISL: Multiple imputation by super learning	6
Bayesian analysis of joint quantile regression for multi-response longitudinal data with application to primary biliary cirrhosis sequential cohort study	5
A new framework for semi-Markovian parametric multi-state models with interval censoring	5
Survival models induced by zero-modified power series discrete frailty: Application with a melanoma data set	5
Multiple imputation approaches for epoch-level accelerometer data in trials	5
Mid-quantile regression for discrete responses	5
A Bayesian latent class approach to causal inference with longitudinal data	5
Adaptive enrichment trial designs using joint modelling of longitudinal and time-to-event data	5
Generalized fiducial inference for the restricted mean survival time	5
Comparison of statistical methods for the analysis of patient-reported outcomes in randomised controlled trials: A simulation study	5
Semiparametric generalized estimating equations for repeated measurements in cross-over designs	5
Simulation extrapolation method for measurement error: A review	5
Using Bayesian evidence synthesis to quantify uncertainty in population trends in smoking behaviour	5
A Weibull mixture cure frailty model for high-dimensional covariates	5
Estimation in discrete time coarsened multivariate longitudinal models	5
A robust variable screening procedure for ultra-high dimensional data	5
Use of clinical tolerance limits for assessing agreement	5
Solutions to problems of nonexistence of parameter estimates and sparse data bias in Poisson regression	5
Editorial	5
The “Why” behind including “Y” in your imputation model	5
Group lasso priors for Bayesian accelerated failure time models with left-truncated and interval-censored data	5
Using short-term endpoints to improve interim decision making and trial duration in two-stage phase II trials with nested binary endpoints	5
Local linear approximation with Laplacian smoothing penalty and application in biology	5
Combining multiple biomarkers linearly to minimize the Euclidean distance of the closest point on the receiver operating characteristic surface to the perfection corner in trichotomous settings	5
Time-dependent receiver operating characteristic curve estimator for correlated right-censored time-to-event data	5
Bivariate copula regression models for semi-competing risks	5
Sample sizes required to estimate the protective efficacy of a vaccine when there is an unequal allocation of individuals across the vaccine and placebo groups	5
Unbiased and robust analysis of co-localization in super-resolution images	5
A generalized epidemiological model with dynamic and asymptomatic population	5
Simulating time-to-event data subject to competing risks and clustering: A review and synthesis	4
An overview of optimal designs under a given budget in cluster randomized trials with a binary outcome	4
Quantile outcome adaptive lasso: Covariate selection for inverse probability weighting estimator of quantile treatment effects	4
LASSO-type instrumental variable selection methods with an application to Mendelian randomization	4
Distribution-free control charts for mixed-type data based on rank of interpoint distances	4
MEGH: A parametric class of general hazard models for clustered survival data	4
Average treatment effect on the treated, under lack of positivity	4
Variable selection with missing data in both covariates and outcomes: Imputation and machine learning	4
Covariate-adjusted inference for doubly adaptive biased coin design	4
Additive hazards model with time-varying coefficients and imaging predictors	4
Fallopian tube anatomy predicts pregnancy and pregnancy outcomes after tubal reversal surgery	4
A new measure to quantify sedentary behavior using accelerometer data: Application to the Hispanic Community Health Study/Study of Latinos	4
Factorial survival analysis for treatment effects under dependent censoring	4
Heterogeneous treatment effect estimation for observational data using model-based forests	4
Bayesian variable selection in hierarchical difference-in-differences models	4
Divided-and-combined omnibus test for genetic association analysis with high-dimensional data	4
Causal rule ensemble method for estimating heterogeneous treatment effect with consideration of prognostic effects	4
Regularization approaches in clinical biostatistics: A review of methods and their applications	4
The change in estimate method for selecting confounders: A simulation study	4
Comparisons of various estimates of the I2 statistic for quantifying between-study heterogeneity in meta-analysis	4
Data-driven clustering of infectious disease incidence into age groups	4
Unified approach to optimal estimation of mean and standard deviation from sample summaries	4
Estimating the sample mean and standard deviation from order statistics and sample size in meta-analysis	4
Variance partitioning in spatio-temporal disease mapping models	4
An objective Bayesian approach to estimation in multistage experiments	4
Biomarker-driven optimal designs for patient enrollment restriction	4
Extended excess hazard models for spatially dependent survival data	4
Modeling treatment effect modification in multidrug-resistant tuberculosis in an individual patientdata meta-analysis	3
Graphical methods to illustrate the nature of the relation between a continuous variable and the outcome when using restricted cubic splines with a Cox proportional hazards model	3
Authors’ response	3
Uniformization and bounded Taylor series in Newton–Raphson method improves computational performance for a multistate transition model estimation and inference	3
Novel empirical likelihood inference for the mean difference with right-censored data	3
Sample size determination for adaptive crossover trial in detecting gene-drug interactions	3
Applications of simple and accessible methods for meta-analysis involving rare events: A simulation study	3
Isotonic design for single-arm biomarker stratified trials	3
Estimating dynamic treatment regimes for ordinal outcomes with household interference: Application in household smoking cessation	3
Mean corrected generalized estimating equations for longitudinal binary outcomes with report bias	3
Efficient estimation of the marginal mean of recurrent events in randomized controlled trials	3

Modified interactive Q-learning for attenuating the impact of model misspecification with treatment effect heterogeneity	3
An efficient approach for optimizing the cost-effective individualized treatment rule using conditional random forest	3
Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number	3
Online control of the False Discovery Rate in group-sequential platform trials	3
Weighting methods for truncation by death in cluster-randomized trials	3
Conditional copula models for correlated survival endpoints: Individual patient data meta-analysis of randomized controlled trials	3
Efficient algorithms for survival data with multiple outcomes using the frailty model	3
A natural history and copula-based joint model for regional and distant breast cancer metastasis	3
Cross-validation approaches for penalized Cox regression	3
Bayesian semiparametric joint modeling of a count outcome and inconveniently timed longitudinal predictors	3
Exponentially weighed moving average charts for monitoring zero-inflated proportions with applications in health care	3
Clustering functional data using forward search based on functional spatial ranks with medical applications	3
Optimising error rates in programmes of pilot and definitive trials using Bayesian statistical decision theory	3
Multiple imputation analysis for propensity score matching with missing causes of failure: An application to hepatocellular carcinoma data	3
Youden index estimation based on group-tested data	3
Improving estimation efficiency of case-cohort studies with interval-censored failure time data	3
A distribution-free smoothed combination method to improve discrimination accuracy in multi-category classification	3
A statistical framework for planning and analysing test–retest studies of repeatability	3
Variable selection for mixed panel count data under the proportional mean model	3
Model detection for semiparametric accelerated failure additive model with right-censored data	3
Does it decay? Obtaining decaying correlation parameter values from previously analysed cluster randomised trials	3
Multivariate contaminated normal linear mixed models applied to Alzheimer’s disease study with censored and missing data	3
A family of estimators to diagnostic accuracy when candidate tests are subject to detection limits—Application to diagnosing early stage Alzheimer disease	3
A comparison of various aggregation functions in multi-criteria decision analysis for drug benefit–risk assessment	3
Optimal allocation to treatments in a sequential multiple assignment randomized trial	3
A Bayesian hierarchical model for the analysis of visual analogue scaling tasks	3
Using information criteria to select smoothing parameters when analyzing survival data with time-varying coefficient hazard models	3
Functional joint models for chronic kidney disease in kidney transplant recipients	3
Semi-parametric testing for ordinal treatment effects in time-to-event data via dynamic Dirichlet process mixtures of the inverse-Gaussian distribution	3
Multicategory matched learning for estimating optimal individualized treatment rules in observational studies with application to a hepatocellular carcinoma study	3
Comparison of random forest methods for conditional average treatment effect estimation with a continuous treatment	3
Methods for comparative effectiveness based on time to confirmed disability progression with irregular observations in multiple sclerosis	3
Integrating relative survival in multi-state models—a non-parametric approach	3
Association of intracluster correlation measures with outcome prevalence for binary outcomes in cluster randomised trials	3
Wilcoxon rank-sum tests to detect one-sided mixture alternatives in group sequential clinical trials	3
Measuring the individualization potential of treatment individualization rules: Application to rules built with a new parametric interaction model for parallel-group clinical trials	3
Shared parameter and copula models for analysis of semicontinuous longitudinal data with nonrandom dropout and informative censoring	3
Bivariate joint models for survival and change of cognitive function	3
Intervention treatment distributions that depend on the observed treatment process and model double robustness in causal survival analysis	3
Jointly assessing multiple endpoints in pilot and feasibility studies	3
Bayesian multiple Gaussian graphical models for multilevel variables from unknown classes	2
Dirichlet process mixture models for regression discontinuity designs	2
A novel rare variants association test for binary traits in family-based designs via copulas	2
A class of two-sample nonparametric statistics for binary and time-to-event outcomes	2
ROSIE: RObust Sparse ensemble for outlIEr detection and gene selection in cancer omics data	2
Determination of correlations in multivariate count data with informative observation times	2
On estimating the area under the ROC curve in ranked set sampling	2
Boosting distributional copula regression for bivariate binary, discrete and mixed responses	2
Multiple imputation for cause-specific Cox models: Assessing methods for estimation and prediction	2
Variable selection using inverse probability of censoring weighting	2
Nonparametric Bayesian functional selection in 1-M matched case-crossover studies	2
Variable selection for a mark-specific additive hazards model using the adaptive LASSO	2
Partial areas under the curve of the cumulative distribution function as a new composite estimand for randomized clinical trials	2
Group sequential methods based on supremum logrank statistics under proportional and nonproportional hazards	2
Refined moderation analysis with binary outcomes in precision medicine research	2
Data-dependent early completion of dose-finding trials for drug-combination	2
Joint regression analysis of clustered current status data with latent variables	2
Propensity score weighting methods for causal subgroup analysis with time-to-event outcomes	2
A model-based approach for historical borrowing, with an application to neovascular age-related macular degeneration	2
Non-parametric approach for frequentist multiple imputation in survival analysis with missing covariates	2
Sample size determination for stepped wedge cluster randomized trials in pragmatic settings	2
Evaluations of the sum-score-based and item response theory-based tests of group mean differences under various simulation conditions	2
Hierarchical Bayesian bivariate spatial modeling of small area proportions with application to health survey data	2
Multivariate control charts for monitoring a bivariate correlated count process with application to meningococcal disease	2
Marginal semiparametric accelerated failure time cure model for clustered survival data	2
An overview of propensity score matching methods for clustered data	2
Estimating transformations for evaluating diagnostic tests with covariate adjustment	2
Dealing with missing information on covariates for excess mortality hazard regression models – Making the imputation model compatible with the substantive model	2
On estimating a constrained bivariate random effects model for meta-analysis of test accuracy studies	2
Estimating latent, dynamic processes of breast cancer tumour growth and distant metastatic spread from mammography screening data	2
Conversion of non-inferiority margin from hazard ratio to restricted mean survival time difference using data from multiple historical trials	2
The performance of marginal structural models for estimating risk differences and relative risks using weighted univariate generalized linear models	2
Partly linear single-index cure models with a nonparametric incidence link function	2
Causal mediation analysis with multiple causally non-ordered and ordered mediators based on summarized genetic data	2
Logistic regression with correlated measurement error and misclassification in covariates	2
Assigning readers to cases in imaging studies using balanced incomplete block designs	2
Matching ratio and sample size for optimal sequential testing with binomial data	2
Robust regression with asymmetric loss functions	2
Instrumental variable analysis with categorical treatment	2
Unit information prior for incorporating real-world evidence into randomized controlled trials	2
A matching-based machine learning approach to estimating optimal dynamic treatment regimes with time-to-event outcomes	2
Methods for non-proportional hazards in clinical trials: A systematic review	2
Using joint models for longitudinal and time-to-event data to investigate the causal effect of salvage therapy after prostatectomy	2
On the estimation of population size—A comparison of capture-recapture and multiplier-benchmark methods	2
Considerations on the region of interest in the ROC space	2
Adaptive aggregation for longitudinal quantile regression based on censored history process	2
A functional proportional hazard cure rate model for interval-censored data	2
Adaptive group sequential survival comparisons based on log-rank and pointwise test statistics	2
Compositional functional regression and isotemporal substitution analysis: Methods and application in time-use epidemiology	2
Nonparametric Bayesian Q-learning for optimization of dynamic treatment regimes in the presence of partial compliance	2
Sample size estimation for comparing dynamic treatment regimens in a SMART: A Monte Carlo-based approach and case study with longitudinal overdispersed count outcomes	2
Frequentist rules for regulatory approval of subgroups in phase III trials: A fresh look at an old problem	1
Copula modeling for the estimation of measures of marker classification and predictiveness performance with survival outcomes	1
Flexible joint model for time-to-event and non-Gaussian longitudinal outcomes	1
Estimating drug concentration–response relationships by applying causal inference methods for continuous point exposures and time-to-event outcomes	1