Statistical Methods in Medical Research

Article	Citations
A tutorial on frailty models	108
Mixed-effects models for the design and analysis of stepped wedge cluster randomized trials: An overview	86
Regression shrinkage methods for clinical prediction models do not guarantee improved performance: Simulation study	52
Propensity score weighting under limited overlap and model misspecification	47
Bootstrap inference for multiple imputation under uncongeniality and misspecification	41
Estimation of causal effects of multiple treatments in observational studies with a binary outcome	39
Random forests for high-dimensional longitudinal data	38
Predictive performance of machine and statistical learning methods: Impact of data-generating processes on external validity in the “large N, small p” setting	33
Comparison of small-sample standard-error corrections for generalised estimating equations in stepped wedge cluster randomised trials with a binary outcome: A simulation study	32
Multiple imputation with missing data indicators	30
Hybrid test for publication bias in meta-analysis	28
Adjusted win ratio with stratification: Calculation methods and interpretation	27
Estimating the sample mean and standard deviation from order statistics and sample size in meta-analysis	27
Estimation of required sample size for external validation of risk models for binary outcomes	24
Small sample sizes: A big data problem in high-dimensional data analysis	24
Sample size and sample composition for constructing growth reference centiles	23
Bayesian cluster hierarchical model for subgroup borrowing in the design and analysis of basket trials with binary endpoints	23
Conditional copula models for correlated survival endpoints: Individual patient data meta-analysis of randomized controlled trials	23
Propensity score-based methods for causal inference in observational studies with non-binary treatments	20
Performance of propensity score matching to estimate causal effects in small samples	19
Spatial scan statistics can be dangerous	19
A study of alternative approaches to non-normal latent trait distributions in item response theory models used for health outcome measurement	19
Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number	16
Functional survival forests for multivariate longitudinal outcomes: Dynamic prediction of Alzheimer’s disease progression	16
Regression multiple imputation for missing data analysis	16

Sample size calculation and re-estimation based on the prevalence in a single-arm confirmatory diagnostic accuracy study	15
Adjusting for selection bias due to missing data in electronic health records-based research	15
Mediation effects that emulate a target randomised trial: Simulation-based evaluation of ill-defined interventions on multiple mediators	15
A Bayesian approach for analyzing partly interval-censored data under the proportional hazards model	14
A Bayesian dose–response meta-analysis model: A simulations study and application	14
Utilizing time series data embedded in electronic health records to develop continuous mortality risk prediction models using hidden Markov models: A sepsis case study	14
Commentary on the use of the reproduction number R during the COVID-19 pandemic	14
Minimum sample size for developing a multivariable prediction model using multinomial logistic regression	13
Glucodensities: A new representation of glucose profiles using distributional data analysis	13
Sample size estimation for modified Poisson analysis of cluster randomized trials with a binary outcome	13
Reference range: Which statistical intervals to use?	13
Detecting the skewness of data from the five-number summary and its application in meta-analysis	13
Improved two-stage estimation to adjust for treatment switching in randomised trials: g-estimation to address time-dependent confounding	12
The change in estimate method for selecting confounders: A simulation study	12
Statistical methods used to combine the effective reproduction number, R(t), and other related measures of COVID-19 in the UK	12
Group sequential monitoring based on the maximum of weighted log-rank statistics with the Fleming–Harrington class of weights in oncology clinical trials	12
Propensity score analysis methods with balancing constraints: A Monte Carlo study	11
Unbiasedness and efficiency of non-parametric and UMVUE estimators of the probabilistic index and related statistics	11
K-sample omnibus non-proportional hazards tests based on right-censored data	11
Methods for modelling excess mortality across England during the COVID-19 pandemic	11
Handling missing data in modelling quality of clinician-prescribed routine care: Sensitivity analysis of departure from missing at random assumption	11
Accurate confidence intervals for proportion in studies with clustered binary outcome	11
Analysing body composition as compositional data: An exploration of the relationship between body composition, body mass and bone strength	10
Nonparametric hyperrectangular tolerance and prediction regions for setting multivariate reference regions in laboratory medicine	10
Advances in propensity score analysis	10
General regression methods for respondent-driven sampling data	10
Meta-analysis of the severe acute respiratory syndrome coronavirus 2 serial intervals and the impact of parameter uncertainty on the coronavirus disease 2019 reproduction number	10
Weighted log-rank tests for clustered censored data: Saddlepoint p-values and confidence intervals	10
Revisiting performance metrics for prediction with rare outcomes	9
Extending the I-squared statistic to describe treatment effect heterogeneity in cluster, multi-centre randomized trials and individual patient data meta-analysis	9
Inferring risks of coronavirus transmission from community household data	9
Dealing with risk discontinuities to estimate cancer mortality risks when the number of small areas is large	9
A working likelihood approach for robust regression	9
Developing clinical prediction models when adhering to minimum sample size recommendations: The importance of quantifying bootstrap variability in tuning parameters and predictive performance	9
On recurrent-event win ratio	8
Flexible extension of the accelerated failure time model to account for nonlinear and time-dependent effects of covariates on the hazard	8
Improving convergence in growth mixture models without covariance structure constraints	8
Variable selection with missing data in both covariates and outcomes: Imputation and machine learning	8
Two-phase analysis and study design for survival models with error-prone exposures	8
Criteria for evaluating risk prediction of multiple outcomes	8
Change point detection in Cox proportional hazards mixture cure model	8
The probability of detection of SARS-CoV-2 in saliva	8
Inferring median survival differences in general factorial designs via permutation tests	8
Variable selection for causal mediation analysis using LASSO-based methods	8
Regularization approaches in clinical biostatistics: A review of methods and their applications	8
A unified approach to variable selection for Cox’s proportional hazards model with interval-censored failure time data	8
Evaluating upper limb function after stroke using the free-living accelerometer data	8
Standard error estimation in meta-analysis of studies reporting medians	8
Bayesian quantile nonhomogeneous hidden Markov models	8
Applications of simple and accessible methods for meta-analysis involving rare events: A simulation study	8

Class imbalance in gradient boosting classification algorithms: Application to experimental stroke data	8
Semiparametric integrative interaction analysis for non-small-cell lung cancer	8
Statistical design considerations for trials that study multiple indications	8
Online control of the familywise error rate	7
MultiBaC: A strategy to remove batch effects between different omic data types	7
A threshold linear mixed model for identification of treatment-sensitive subsets in a clinical trial based on longitudinal outcomes and a continuous covariate	7
Relative efficiencies of alternative preference-based designs for randomised trials	7
Estimating a time-to-event distribution from right-truncated data in an epidemic: A review of methods	7
Efficient and flexible simulation-based sample size determination for clinical trials with multiple design parameters	7
An overview of propensity score matching methods for clustered data	7
Bayesian multiple instance regression for modeling immunogenic neoantigens	7
CWL: A conditional weighted likelihood method to account for the delayed joint toxicity–efficacy outcomes for phase I/II clinical trials	7
Distance-based Classification and Regression Trees for the analysis of complex predictors in health and medical research	7
Online control of the False Discovery Rate in group-sequential platform trials	7
Expanding attributable fraction applications to outcomes wholly attributable to a risk factor	7
Improving the estimation of the COVID-19 effective reproduction number using nowcasting	7
A comparison of two frameworks for multi-state modelling, applied to outcomes after hospital admissions with COVID-19	7
Exploring consequences of simulation design for apparent performance of methods of meta-analysis	7
Variance estimation in tests of clustered categorical data with informative cluster size	7
Deselection of base-learners for statistical boosting—with an application to distributional regression	7
Efficiency of a randomized confirmatory basket trial design constrained to control the family wise error rate by indication	7
An adaptive seamless Phase 2-3 design with multiple endpoints	7
Modified Brier score for evaluating prediction accuracy for binary outcomes	7
A multinomial quadrivariate D-vine copula mixed model for meta-analysis of diagnostic studies in the presence of non-evaluable subjects	7
G-computation and doubly robust standardisation for continuous-time data: A comparison with inverse probability weighting	6
Dynamic prediction of competing risk events using landmark sub-distribution hazard model with multiple longitudinal biomarkers	6
Risk difference tests for stratified binary data under Dallal’s model	6
A surface-free design for phase I dual-agent combination trials	6
Spatiotemporal distributed lag modelling of multiple Plasmodium species in a malaria elimination setting	6
Sample sizes for cluster-randomised trials with continuous outcomes: Accounting for uncertainty in a single intra-cluster correlation estimate	6
Selecting the number of categories of the lymph node ratio in cancer research: A bootstrap-based hypothesis test	6
Mediation analysis for mixture Cox proportional hazards cure models	6
Development of a mixture model allowing for smoothing functions of longitudinal trajectories	6
On estimating the area under the ROC curve in ranked set sampling	6
A comparison of analytical strategies for cluster randomized trials with survival outcomes in the presence of competing risks	6
A generalization of functional clustering for discrete multivariate longitudinal data	6
Correlation-based joint feature screening for semi-competing risks outcomes with application to breast cancer data	6
Challenges of modelling approaches for network meta-analysis of time-to-event outcomes in the presence of non-proportional hazards to aid decision making: Application to a melanoma network	6
A family of Gamma-generated distributions: Statistical properties and applications	6
Nonlinear parametric quantile models	5
Inference about age-standardized rates with sampling errors in the denominators	5
Employing a latent variable framework to improve efficiency in composite endpoint analysis	5
Re-randomisation trials in multi-episode settings: Estimands and independence estimators	5
Continuous(ly) missing outcome data in network meta-analysis: A one-stage pattern-mixture model approach	5
Pairwise likelihood estimation of latent autoregressive count models	5
Quantile regression models for survival data with missing censoring indicators	5
Asymptotic permutation tests for coefficients of variation and standardised means in general one-way ANOVA models	5
Survival analysis with change-points in covariate effects	5
Statistical reproducibility for pairwise t-tests in pharmaceutical research	5
Using gradient boosting with stability selection on health insurance claims data to identify disease trajectories in chronic obstructive pulmonary disease	5
An improved one-sample log-rank test	5
On hazard-based penalized likelihood estimation of accelerated failure time model with partly interval censoring	5
Integrating latent classes in the Bayesian shared parameter joint model of longitudinal and survival outcomes	5
Robust bivariate random-effects model for accommodating outlying and influential studies in meta-analysis of diagnostic test accuracy studies	5
A semiparametric mixed-effects model for censored longitudinal data	5
Regression analysis of multivariate interval-censored failure time data with informative censoring	5
Unified approach to optimal estimation of mean and standard deviation from sample summaries	5
Combining cox regressions across a heterogeneous distributed research network facing small and zero counts	5
A robust variable screening procedure for ultra-high dimensional data	5
Benchmarking survival outcomes: A funnel plot for survival data	5
A Bayesian phase I/II biomarker-based design for identifying subgroup-specific optimal dose for immunotherapy	5
A general method for calculating power for GEE analysis of complete and incomplete stepped wedge cluster randomized trials	5
A method for systematically ranking therapeutic drug candidates using multiple uncertain screening criteria	5
Random effects models for complex designs	5
An effective technique for diabetic retinopathy using hybrid machine learning technique	5
Bayesian variable selection in logistic regression with application to whole-brain functional connectivity analysis for Parkinson’s disease	5
Imputation and missing indicators for handling missing data in the development and deployment of clinical prediction models: A simulation study	5
A group sequential design and sample size estimation for an immunotherapy trial with a delayed treatment effect	5
A review of multistate modelling approaches in monitoring disease progression: Bayesian estimation using the Kolmogorov-Chapman forward equations	5
Bayesian nonparametric latent class model for longitudinal data	5
Association of intracluster correlation measures with outcome prevalence for binary outcomes in cluster randomised trials	4
Adjusting for time of infection or positive test when estimating the risk of a post-infection outcome in an epidemic	4
Optimized multiple testing procedures for nested sub-populations based on a continuous biomarker	4
Optimal two-stage sampling for mean estimation in multilevel populations when cluster size is informative	4
A comparison of various aggregation functions in multi-criteria decision analysis for drug benefit–risk assessment	4
Clustering clinical and health care processes using a novel measure of dissimilarity for variable-length sequences of ordinal states	4
Estimation of the proportion of true null hypotheses under sparse dependence: Adaptive FDR controlling in microarray data	4
Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates	4
Modeling the probability of occurrence of events	4
Dynamic predictions of kidney graft survival in the presence of longitudinal outliers	4

Clustered longitudinal data subject to irregular observation	4
Integrating relative survival in multi-state models—a non-parametric approach	4
Inference under covariate-adaptive randomization: A simulation study	4
Clustering functional data using forward search based on functional spatial ranks with medical applications	4
Ranking procedures for repeated measures designs with missing data: Estimation, testing and asymptotic theory	4
Bayesian adaptive decision-theoretic designs for multi-arm multi-stage clinical trials	4
A variance shrinkage method improves arm-based Bayesian network meta-analysis	4
Prediction of cancer survival for cohorts of patients most recently diagnosed using multi-model inference	4
Robust statistical inference for matched win statistics	4
A survival mediation model with Bayesian model averaging	4
Causal mediation analysis with multiple causally non-ordered and ordered mediators based on summarized genetic data	4
A permutation test for assessing the presence of individual differences in treatment effects	4
Joint space–time Bayesian disease mapping via quantification of disease risk association	4
Generalized quasi-linear mixed-effects model	4
Multiple imputation for cause-specific Cox models: Assessing methods for estimation and prediction	3
Sample size determination for stepped wedge cluster randomized trials in pragmatic settings	3
Data-driven clustering of infectious disease incidence into age groups	3
Probability intervals of toxicity and efficacy design for dose-finding clinical trials in oncology	3
Leveraging historical data to optimize the number of covariates and their explained variance in the analysis of randomized clinical trials.	3
Decision-making with multiple correlated binary outcomes in clinical trials	3
Semiparametric regression of the illness-death model with interval censored disease incidence time: An application to the ACLS data	3
Flexible modeling of multiple nonlinear longitudinal trajectories with censored and non-ignorable missing outcomes	3
A dose–effect network meta-analysis model with application in antidepressants using restricted cubic splines	3
Modeling treatment effect modification in multidrug-resistant tuberculosis in an individual patientdata meta-analysis	3
Homogeneity testing for binomial proportions under stratified double-sampling scheme with two fallible classifiers	3
Inference on the overlap coefficient: The binormal approach and alternatives	3
Functional clustering methods for longitudinal data with application to electronic health records	3
Ensemble methods for survival function estimation with time-varying covariates	3
Evaluating Bayesian adaptive randomization procedures with adaptive clip methods for multi-arm trials	3
Reference-based pattern-mixture models for analysis of longitudinal binary data	3
Multivariate generalized linear mixed models for continuous bounded outcomes: Analyzing the body fat percentage data	3
Nonparametric kernel estimation of the probability of cure in a mixture cure model when the cure status is partially observed	3
Propensity score specification for optimal estimation of average treatment effect with binary response	3
Net benefit separation and the determination curve: A probabilistic framework for cost-effectiveness estimation	3
On estimating a constrained bivariate random effects model for meta-analysis of test accuracy studies	3
Uncertainty quantification for epidemiological forecasts of COVID-19 through combinations of model predictions	3
The analysis of COVID-19 in-hospital mortality: A competing risk approach or a cure model?	3
Exponentially weighed moving average charts for monitoring zero-inflated proportions with applications in health care	3
The population-wise error rate for clinical trials with overlapping populations	3
A family of linear mixed-effects models using the generalized Laplace distribution	3
Harmonizing child mortality data at disparate geographic levels	3
Weighted functional linear Cox regression model	3
A unified approach to power and sample size determination for log-rank tests under proportional and nonproportional hazards	3
Mediational g-formula for time-varying treatment and repeated-measured multiple mediators: Application to atorvastatin’s effect on cardiovascular disease via cholesterol lowering and anti-inflammatory	3
Missing item responses in latent growth analysis: Item response theory versus classical test theory	3
MEGH: A parametric class of general hazard models for clustered survival data	3
Variable selection for ultra-high dimensional quantile regression with missing data and measurement error	3
Reference ranges: Why tolerance intervals should not be used. Comment on Liu, Bretz and Cortina-Borja, Reference range: Which statistical intervals to use? SMMR, 2021,Vol. 30(2) 523–534	3
Bayesian approaches to the weighted kappa-like inter-rater agreement measures	3
A competing risks regression model for the association between time-varying opioid exposure and risk of overdose	3
CFO: Calibration-free odds design for phase I/II clinical trials	3
The asymptotic distribution of the Net Benefit estimator in presence of right-censoring	3
A distribution-free control charting technique based on change-point analysis for detection of epidemics	3
Inference for the treatment effect in longitudinal cluster randomized trials when treatment effect heterogeneity is ignored	3
Robust regression with asymmetric loss functions	3
Unbiased and robust analysis of co-localization in super-resolution images	3
Nested logistic regression models and ΔAUC applications: Change-point analysis	2
Optimal individualized decision rules from a multi-arm trial: A comparison of methods and an application to tailoring inter-donation intervals among blood donors in the UK	2
Bayesian inference on the number of recurrent events: A joint model of recurrence and survival	2
Data transformations for statistical assessment of quantitative imaging biomarkers: Application to lung nodule volumetry	2
A pseudo-likelihood approach for multivariate meta-analysis of test accuracy studies with multiple thresholds	2
Doubly-robust estimator of the difference in restricted mean times lost with competing risks data	2
Quantile regression on inactivity time	2
Repeated measures discriminant analysis using multivariate generalized estimation equations	2
A Bayesian group lasso classification for ADNI volumetrics data	2
A competing risks model with binary time varying covariates for estimation of breast cancer risks in BRCA1 families	2
Model-robust designs for nonlinear quantile regression	2
A functional proportional hazard cure rate model for interval-censored data	2
Variance partitioning in spatio-temporal disease mapping models	2
Semiparametric estimation of the proportional rates model for recurrent events data with missing event category	2
Calibrating validation samples when accounting for measurement error in intervention studies	2
Analyzing the overall effects of the microbiome abundance data with a Bayesian predictive value approach	2
Semiparametric copula method for semi-competing risks data subject to interval censoring and left truncation: Application to disability in elderly	2
A novel power prior approach for borrowing historical control data in clinical trials	2
Combined statistical decision limits based on two GH-2000 scores for the detection of growth hormone misuse	2
Calibration of surgical tools using multilevel modeling with LINEX loss function: Theory and experiment	2
Impact of minimal sufficient balance, minimization, and stratified permuted blocks on bias and power in the estimation of treatment effect in sequential clinical trials with a binary endpoint	2
A state-space approach for longitudinal outcomes: An application to neuropsychological outcomes	2
Adaptive group sequential survival comparisons based on log-rank and pointwise test statistics	2
A sequential test to compare the real-time fatality rates of a disease among multiple groups with an application to COVID-19 data	2
Approximate Bayesian computation design for phase I clinical trials	2
Path-specific effects in the presence of a survival outcome and causally ordered multiple mediators with application to genomic data	2
Simulation extrapolation method for measurement error: A review	2
Issues and solutions in biomarker evaluation when subclasses are involved under binary classification	2
Time-varying coefficient additive hazards model with latent variables	2
Integrative nearest neighbor classifier for block-missing multi-modality data	2
Estimating latent, dynamic processes of breast cancer tumour growth and distant metastatic spread from mammography screening data	2
Revisiting Gaussian Markov random fields and Bayesian disease mapping	2
Approximate Bayesian inference for joint linear and partially linear modeling of longitudinal zero-inflated count and time to event data	2
Modeling comorbidity of chronic diseases using coupled hidden Markov model with bivariate discrete copula	2
Promising zone two-stage design for a single-arm study with binary outcome	2
Analysis of survival data with cure fraction and variable selection: A pseudo-observations approach	2
Goodness-of-fit tests for a logistic regression model with missing covariates	2
Evaluations of the sum-score-based and item response theory-based tests of group mean differences under various simulation conditions	2
Variance estimation for the average treatment effects on the treated and on the controls	2