Bioorganic & Medicinal Chemistry Letters

Article	Citations
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir	139
Pyridones in drug discovery: Recent advances	82
Structural hybridization as a facile approach to new drug candidates	72
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study	63
1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies	61
The expanding reaction toolkit for DNA-encoded libraries	59
Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents	58
Recent advances in antibacterial agents	56
Cryo-EM as a powerful tool for drug discovery	56
Synthesis and biological evaluation of anti-tubercular activity of Schiff bases of 2-Amino thiazoles	44
A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation	43
Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition	42
A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)	42
Click synthesis of 1,2,3-triazole based imidazoles: Antitubercular evaluation, molecular docking and HSA binding studies	41
New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants	41
Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax	37
Structure–activity relationships of GPX4 inhibitor warheads	37
Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents	34
Design and synthesis of new indanol-1,2,3-triazole derivatives as potent antitubercular and antimicrobial agents	34
Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus	34
Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies	32
Fused benzo[1,3]thiazine-1,2,3-triazole hybrids: Microwave-assisted one-pot synthesis, in vitro antibacterial, antibiofilm, and in silico ADME studies	31
Exploring the potential of novel phenolic compounds as potential therapeutic candidates against SARS-CoV-2, using quantum chemistry, molecular docking and dynamic studies	31
Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor	30
Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors	30

Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole	29
Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus	28
Chemical update on the potential for serotonin 5-HT6 and 5-HT7 receptor agents in the treatment of Alzheimer’s disease	27
Design and synthesis of purine connected piperazine derivatives as novel inhibitors of Mycobacterium tuberculosis	26
Holistic drug design for multiparameter optimization in modern small molecule drug discovery	26
Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease	26
Promising anti-SARS-CoV-2 drugs by effective dual targeting against the viral and host proteases	26
Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety	25
Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation	25
Preparations and antioxidant activities of sesamol and it's derivatives	25
Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton	25
Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity	24
Design, synthesis and molecular modeling studies of novel mesalamine linked coumarin for treatment of inflammatory bowel disease	24
Design, synthesis and molecular docking studies of imidazole and benzimidazole linked ethionamide derivatives as inhibitors of InhA and antituberculosis agents	24
Assessing different thiazolidine and thiazole based compounds as antileishmanial scaffolds	24
Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies	24
Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease	23
Green synthesis of therapeutically active 1,3,4-oxadiazoles as antioxidants, selective COX-2 inhibitors and their in silico studies	23
Angiokinase inhibition of VEGFR-2, PDGFR and FGFR and cell growth inhibition in lung cancer: Design, synthesis, biological evaluation and molecular docking of novel azaheterocyclic coumarin derivative	23
Medicinal chemistry strategies to extend duration of action of inhaled drugs for intracellular targets	23
Targeting G-quadruplexes to achieve antiviral activity	23
Progress of tubulin polymerization activity detection methods	23
Molecular docking and synthesis of caffeic acid analogous and its anti-inflammatory, analgesic and ulcerogenic studies	23
Targeting epigenetic modulators using PROTAC degraders: Current status and future perspective	23
Design, synthesis, characterization, and anticancer activity of a novel series of O-substituted chalcone derivatives	23
Antibacterial activity of β-sitosterol isolated from the leaves of Odontonema strictum (Acanthaceae)	22
One-step radiosynthesis and initial evaluation of a small molecule PET tracer for PD-L1 imaging	22
In vitro antifungal activities, molecular docking, and DFT studies of 4-amine-3-hydrazino-5-mercapto-1,2,4-triazole derivatives	22
Synthesis of novel quinoxaline-alkynyl derivatives and their anti-Mycobacterium tuberculosis activity	22
Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis	22
Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors	21
Synthesis of novel potent cytotoxicy podophyllotoxin-naphthoquinone compounds via microwave-assited multicomponent domino reactions	21
Novel dual LSD1/HDAC6 inhibitors for the treatment of multiple myeloma	21
New thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, molecular modeling and ADMET study	20
Selections and screenings of DNA-encoded chemical libraries against enzyme and cellular targets	20
A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors	20
Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2	20
Synthesis and biological evaluation of novel ligustrazine-chalcone derivatives as potential anti-triple negative breast cancer agents	20
Design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents	20
2-Aryl-3-(6-trifluoromethoxy)benzo[d]thiazole-based thiazolidinone hybrids as potential anti-infective agents: Synthesis, biological evaluation and molecular docking studies	19
Potential α-glucosidase inhibitor from Hylotelephium erythrostictum	19
Preparation and antioxidant study of silver nanoparticles of Microsorum pteropus methanol extract	19
Ultrasound assisted synthesis of tetrazole based pyrazolines and isoxazolines as potent anticancer agents via inhibition of tubulin polymerization	19
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines	19
Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration	18
Design, synthesis and in vitro antitumor evaluation of novel pyrazole-benzimidazole derivatives	18
FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity	18
Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease	18
Cellular and non-target metabolomics approaches to understand the antifungal activity of methylaervine against Fusarium solani	18
Discovery of β-carboline-(phenylsulfonyl)furoxan hybrids as potential anti-breast cancer agents	18

Synthesis and biological evaluation of novel benzo[a]pyridazino[3,4-c]phenazine derivatives	18
Synthesis and biological evaluation of new 2‑substituted‑4‑amino-quinolines and -quinazoline as potential antifungal agents	18
Free radical scavenging activities of verbascoside and isoverbascoside from the leaves of Odontonema strictum (Acanthaceae)	17
Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor	17
Regioselective hemisynthesis and insecticidal activity of C8-hydrazones/acylhydrazones/sulfonylhydrazones coumarin-type derivatives of osthole	17
Discovery of a simplified deguelin analog as an HSP90 C-terminal inhibitor for HER2-positive breast cancer	17
Design, synthesis and biological evaluation of dual mTOR/HDAC6 inhibitors in MDA-MB-231 cells	17
Towards the enzymatic synthesis of phosphorothioate containing LNA oligonucleotides	17
Trehalose-based neuroprotective autophagy inducers	17
Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent	17
Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors	16
Lipoate-acid ligase a modification of native antibody: Synthesis and conjugation site analysis	16
Cytotoxic components from the leaves of Erythrophleum fordii induce human acute leukemia cell apoptosis through caspase 3 activation and PARP cleavage	16
Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy	16
Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome	16
Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists	16
Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer’s disease	16
Effect of resveratrol on the repair of kidney and brain injuries and its regulation on klotho gene in d-galactose-induced aging mice	16
Influenza antiviral activity of F- and OH-containing isopulegol-derived octahydro-2H-chromenes	15
In silico and in vitro screening for potential anticancer candidates targeting GPR120	15
Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials	15
Noninvasive evaluation of PD-L1 expression using Copper 64 labeled peptide WL12 by micro-PET imaging in Chinese hamster ovary cell tumor model	15
Discovery of novel Hsp90 C-terminal domain inhibitors that disrupt co-chaperone binding	15
Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases	15
Comparison of three zinc binding groups for HDAC inhibitors – A potency, selectivity and enzymatic kinetics study	15
The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition	15
Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection	15
Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors	15
Recent advances toward the development of Hsp90 C-terminal inhibitors	15
Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)	15
Synthesis and biological evaluation of novel 4,7-disubstituted coumarins as selective tumor-associated carbonic anhydrase IX and XII inhibitors	15
Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases	15
New pyrazole-tetrazole hybrid compounds as potent α-amylase and non-enzymatic glycation inhibitors	14
Synthesis and antiproliferative screening of novel doubly modified colchicines containing urea, thiourea and guanidine moieties	14
Synthesis and evaluation of antimycobacterial activity of riboflavin derivatives	14
Novel boronium salt exhibits substantial antibacterial activity when compared to a commercial quaternary ammonium disinfectant	14
Design, synthesis and biological evaluation of novel c-Met/HDAC dual inhibitors	14
Novel hydrazone derivatives of N-amino-11-azaartemisinin with high order of antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice via intramuscular route	14
Design, synthesis and antimicrobial activity of novel 2-aminothiophene containing cyclic and heterocyclic moieties	14
Design, synthesis, and biological evaluation of β-carboline 1,3,4-oxadiazole based hybrids as HDAC inhibitors with potential antitumor effects	14
Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments	14
Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections	14
In vitro anti-Leishmania activity and molecular docking of spiro-acridine compounds as potential multitarget agents against Leishmania infantum	14
Siderophores: Chemical tools for precise antibiotic delivery	14
Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants	14
Fiaud’s Acid, a novel organocatalyst for diastereoselective bis α-aminophosphonates synthesis with in-vitro biological evaluation of antifungal, antioxidant and enzymes inhibition potential	14
Novel molecular hybrids of indoline spiropyrans and α-lipoic acid as potential photopharmacological agents: Synthesis, structure, photochromic and biological properties	14
Discovery of novel VEGFR-2 inhibitors embedding 6,7-dimethoxyquinazoline and diarylamide fragments	14
Novel carboxylated pyrroline-2-one derivatives bearing a phenylhydrazine moiety: Design, synthesis, antifungal evaluation and 3D-QSAR analysis	13
Boronic acid derivative activates pyruvate kinase M2 indispensable for redox metabolism in oral cancer cells	13
Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors	13
Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD)	13
Design, synthesis and evaluation of novel indirubin-based N-hydroxybenzamides, N-hydroxypropenamides and N-hydroxyheptanamides as histone deacetylase inhibitors and antitumor agents	13
Trivalent sulfonium compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles	13
A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar	13
Discovery of sertraline and its derivatives able to combat drug-resistant gastric cancer cell via inducing apoptosis	13
Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans	13
Cytotoxic effects of the biflavonoids isolated from Selaginella trichoclada on MCF-7 cells and its potential mechanism	13
Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors	13
Structure activity relationship of 3-nitro-2-(trifluoromethyl)-2H-chromene derivatives as P2Y6 receptor antagonists	13
Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold	13
Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV)	13
Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders	13
Indolyl-α-keto-1,3,4-oxadiazoles: Synthesis, anti-cell proliferation activity, and inhibition of tubulin polymerization	13
Antimicrobial, modulatory, and antibiofilm activity of tt-farnesol on bacterial and fungal strains of importance to human health	13
Overcoming β-Lactam resistance in Pseudomonas aeruginosa using non-canonical tobramycin-based antibiotic adjuvants	13
Synthesis and biological evaluation of isatin derivatives containing 1,3,4-thiadiazole as potent a-glucosidase inhibitors	13
New lead discovery of insect growth regulators based on the scaffold hopping strategy	13
Pyrazolo[1,5-a]pyrimidine based Trk inhibitors: Design, synthesis, biological activity evaluation	13
Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme	13
Development and evaluation of [18F]Flotaza for Aβ plaque imaging in postmortem human Alzheimer’s disease brain	12
Methods to optimize CNS exposure of drug candidates	12
New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv	12
Synthesis and biofilm inhibition studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones	12
Discovery of novel Staphylococcus aureus penicillin binding protein 2a inhibitors by multistep virtual screening and biological evaluation	12
SFPH proteins as therapeutic targets for a myriad of diseases	12
Discovery of indoline derivatives as anticancer agents via inhibition of tubulin polymerization	12
Design, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles	12
Synthesis, biological evaluation, and correlation of cytotoxicity versus redox potential of 1,4-naphthoquinone derivatives	12
Circular dichroism spectroscopy of DNA duplexes at near-biological concentrations	12

Novel indazole skeleton derivatives containing 1,2,3-triazole as potential anti-prostate cancer drugs	12
Design and synthesis of zinc protoporphyrin IX-adamantane/cyclodextrin/cellulose nanocrystals complexes for anticancer photodynamic therapy	12
Agrochemical properties evaluation of some imines alkaloids of matrine/oxymatrine	12
A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A	12
Interdiction at a protein-protein interface: MCL-1 inhibitors for oncology	12
Synthesis, biological activities, and SAR studies of novel 1-(2-chloro-4,5-difluorophenyl)-1H-pyrazole derivatives	12
Explorations of novel pyridine-pyrimidine hybrid phosphonate derivatives as aurora kinase inhibitors	12
Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond	12
Inhibition of the NorA efflux pump of S. aureus by (Z)-5-(4-Fluorobenzylidene)-Imidazolidines	12
Design, chemical synthesis and antiviral evaluation of 2′-deoxy-2′-fluoro-2′-C-methyl-4′-thionucleosides	12
Computational modeling and target synthesis of monomethoxy-substituted o-diphenylisoxazoles with unexpectedly high antimitotic microtubule destabilizing activity	12
Synthesis, anticancer evaluation, and molecular docking studies of thiazolyl-pyrazoline derivatives	12
Towards multi-target antidiabetic agents: In vitro and in vivo evaluation of 3,5-disubstituted indolin-2-one derivatives as novel α-glucosidase inhibitors	12
Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis	12
Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans	12
Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators	12
Design, synthesis and antitumor activity study of PARP-1/HDAC dual targeting inhibitors	12
Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity	12
Design, synthesis, and antibacterial evaluation of vancomycin-LPS binding peptide conjugates	12
A water-soluble fluorescent probe for real-time visualization of γ-glutamyl transpeptidase activity in living cells	12
Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies	12
Progress towards a stable cephalosporin-halogenated phenazine conjugate for antibacterial prodrug applications	11
Anti-fibrotic effects of brevilin A in hepatic fibrosis via inhibiting the STAT3 signaling pathway	11
Identification of a new class of HBV capsid assembly modulator	11
Evaluation of PNU-159682 antibody drug conjugates (ADCs)	11
Synthesis and antiviral evaluation of cytisine derivatives against dengue virus types 1 and 2	11
Design, synthesis and anticancer activity of 2-amidomethoxy-1,4-naphthoquinones and its conjugates with Biotin/polyamine	11
Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein	11
Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors	11
Synthesis of indole-tethered [1,3,4]thiadiazolo and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids as anti-pancreatic cancer agents	11
Exploration of mercaptoacetamide-linked pyrimidine-1,3,4-oxadiazole derivatives as DNA intercalative topo II inhibitors: Cytotoxicity and apoptosis induction	11
Natural-product-based pesticides: Semisynthesis, structural elucidation, and evaluation of new cholesterol–matrine conjugates as pesticidal agents	11
Rational design, synthesis, antiproliferative activity against MCF-7, MDA-MB-231 cells, estrogen receptors binding affinity, and computational study of indenopyrimidine-2,5-dione analogs for the treat	11
Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents	11
Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents	11
Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases	11
N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins	11
Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors	11
Benzylidene thiazolidinediones: Synthesis, in vitro investigations of antiproliferative mechanisms and in vivo efficacy determination in combination with Imatinib	11
SARS-CoV-2 main protease inhibition by compounds isolated from Luffa cylindrica using molecular docking	11
Synthesis and in vitro antifungal activity of new Michael-type amino derivatives of xanthatin, a natural sesquiterpene lactone from Xanthium strumarium L.	11
Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors	11
Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO)	11
Synthesis and biological evaluation of new series of quinazoline derivatives as EGFR/HER2 dual-target inhibitors	11
Synthesis, docking, machine learning and antiproliferative activity of the 6-ferrocene/heterocycle-2-aminopyrimidine and 5-ferrocene-1H-Pyrazole derivatives obtained by microwave-assisted Atwal reacti	11
Design, synthesis and biological evaluation of dihydrofurocoumarin derivatives as potent neuraminidase inhibitors	11
1,3-Benzodioxole-based fibrate derivatives as potential hypolipidemic and hepatoprotective agents	11
Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists	11
Isolation, structure identification and hepatoprotective activity of a polysaccharide from Sabia parviflora	11
Design and evaluation of 1,2,3-dithiazoles and fused 1,2,4-dithiazines as anti-cancer agents	11
Design, synthesis, and biological evaluation of 2,6,7-substituted pyrrolo[2,3-d]pyrimidines as cyclin dependent kinase inhibitor in pancreatic cancer cells	10
The ester derivatives obtained by C-ring modification of podophyllotoxin induce apoptosis and inhibited proliferation in PC-3M cells via down-regulation of PI3K/Akt signaling pathway	10
Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects	10
Sulfamic acid catalyzed synthesis of new 3,5-[(sub)phenyl]-1H-pyrazole bearing N1-isonicotinoyl: And their pharmacological activity evaluation	10
Design, synthesis and mechanistic studies of a TICT based fluorogenic probe for lighting up protein HSA	10
Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives	10
Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer’s disease	10
Synthesis of crosslinked 2′-OMe RNA duplexes and their application for effective inhibition of miRNA function	10
Ginkgobilol, a new diarylpentanoid and an osteogenic diarylpentanoid analog from Ginkgo biloba leaves	10
Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase	10
Synthesis and fungicidal activity of novel 2-(2-alkylthio-6-phenylpyrimidin-4-yl)-1H-benzimidazoles	10
Synthesis of metronidazole based thiazolidinone analogs as promising antiamoebic agents	10
Photoprotective effect of 18β-glycyrrhetinic acid derivatives against ultra violet (UV)-B-Induced skin aging	10
Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor	10
Vomifoliol isolated from mangrove plant Ceriops tagal inhibits the NFAT signaling pathway with CN as the target enzyme in vitro	10
The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding	10
Discovery of a new class of JMJD6 inhibitors and structure–activity relationship study	10
Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents	10
Design, synthesis and nematicidal activitives of trifluorobutene amide derivatives against Meloidogyne incognita	10
Design, synthesis and anti-TNBC activity of Azeliragon triazole analogues	10
Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase	10
Azobenzene-modified DNA aptamers evolved by capillary electrophoresis (CE)-SELEX method	10
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors	10
Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing	10
Synthesis, fungicidal activity, and 3D-QSAR of tetrazole derivatives containing phenyloxadiazole moieties	10
Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors	10
Discovery and structure–activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors	10
Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors	10
Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation	10
[11C]NCGG401, a novel PET ligand for imaging of colony stimulating factor 1 receptors	10
Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents	10
Design, synthesis and antibacterial evaluation of novel 3-O-substituted 15-membered azalides possessing 1,2,3-triazole side chains	9
Antibacterial activity evaluation of vinyl sulfones against global predominant methicillin-resistant Staphylococcus aureus USA300	9
Design, synthesis and evaluation of 2-(2-oxoethyl)pyrimidine-5-carboxamide derivatives as acetylcholinesterase inhibitors	9
Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase	9
Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC	9
New camptothecin derivatives for generalized oncological chemotherapy: Synthesis, stereochemistry and biology	9
New antibacterial cadiolide analogues active against antibiotic-resistant strains	9
Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts	9
Thiosemicarbazide binds with the dicopper center in the competitive inhibition of mushroom tyrosinase enzyme: Synthesis and molecular modeling of theophylline analogues	9
Design, synthesis, and anti-influenza A virus activity evaluation of novel indole containing derivatives of triazole	9
Mur ligases inhibitors with azastilbene scaffold: Expanding the structure–activity relationship	9
Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/π interaction	9
Discovery of highly potent heme-displacing IDO1 inhibitors based on a spirofused bicyclic scaffold	9
Discovery of an indole-substituted furanone with tubulin polymerization inhibition activity	9