OOIR: Observatory of International Research

Papers

(The H4-Index of Bioorganic & Medicinal Chemistry Letters is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
The SARS-CoV-2 main protease as drug target	531
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir	123
Pyridones in drug discovery: Recent advances	67
The relationship between the structure and toxicity of aminoglycoside antibiotics	61
Structural hybridization as a facile approach to new drug candidates	59
Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents	57
New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation	51
The expanding reaction toolkit for DNA-encoded libraries	51
Recent advances in antibacterial agents	49
Cryo-EM as a powerful tool for drug discovery	47
1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies	45
Structure and bioactivity of colibactin	44
Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents	44
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study	42
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs	40
Discovery and biological evaluation of proteolysis targeting chimeras (PROTACs) as an EGFR degraders based on osimertinib and lenalidomide	35
Recent advances in TRPV4 agonists and antagonists	34
Synthesis and biological evaluation of novel quinazoline-triazole hybrid compounds with potential use in Alzheimer’s disease	33
Design, synthesis, biological evaluation and molecular docking of new uracil analogs-1,2,4-oxadiazole hybrids as potential anticancer agents	33
Synthesis and biological evaluation of anti-tubercular activity of Schiff bases of 2-Amino thiazoles	33
Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus	32
New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants	32
Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects	32
Novel isoniazid embedded triazole derivatives: Synthesis, antitubercular and antimicrobial activity evaluation	31
Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition	31

Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax	30
Synthesis and anti-proliferative activity of a novel 1,2,3-triazole tethered chalcone acetamide derivatives	30
Novel vanillin derivatives containing a 1,3,4-thiadiazole moiety as potential antibacterial agents	30
Click synthesis of 1,2,3-triazole based imidazoles: Antitubercular evaluation, molecular docking and HSA binding studies	30
New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies	30
Structural determinants of affinity and selectivity in the binding of inhibitors to histone deacetylase 6	30