OOIR: Observatory of International Research

Papers

(The TQCC of Human & Experimental Toxicology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma	65
LINC00641 impeded the malignant biological behaviors of papillary thyroid carcinoma cells via interacting with IGF2BP1 to reduce GLI1 mRNA stability	46
Prenatal and early life lead exposure induced neurotoxicity	41
Silver nanoparticles trigger delayed inflammatory responses in mast cells	31
Sevoflurane preconditioning attenuates myocardial cell damage caused by hypoxia and reoxygenation via regulating the NORAD/miR-144-3p axis	30
Development and validation of a novel poisoning agitation-sedation score for predicting the need for endotracheal intubation and mechanical ventilation in acutely poisoned patients with disturbed cons	28
Oxidative stress reactions in rats with pulmonary injuries induced by sulfur mustard (1 LD₅₀)	27
Exploring the utility of zinc finger protein-related genes in predicting hepatocellular carcinoma prognosis, immune responses, and drug efficacy	24
Retraction Notice: “Sulforaphane triggers iron overload-mediated ferroptosis in gastric carcinoma cells by activating the PI3K/IRP2/DMT1 pathway”	21
Effects of doxorubicin on autophagy in fibroblasts	20
Human health risk assessment of heavy metals in different compartments of vegetables from Erbil City-Iraq	19
Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro	19
LINC00294/miR-620/MKRN2 axis provides biomarkers and negatively regulates malignant progression in colorectal carcinoma	19
Effects of methylphenidate on femoral bone growth in male rats	19
Acriflavine protects against LPS-induced sepsis via regulation of pyroptosis, inflammation, and endoplasmic reticulum stress	18
Retraction Notice	18
Effects of polycyclic aromatic hydrocarbon exposure on mitochondrial DNA copy number	17
Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders	17
Relationship between clock gene expression and CYP2C19 and CYP3A4 with benzodiazepines	16
RETRACTED: Ginsenoside Rg5 induces NSCLC cell apoptosis and autophagy through PI3K/Akt/mTOR signaling pathway	16
Exosomes derived from M2 macrophages promote fibroblast autophagy to contribute to hypertrophic scar formation via CXCL2/CXCR7/mTOR pathway	16
Clinical characteristics and the risk factors analysis in patients with delayed encephalopathy after acute carbon monoxide poisoning	16
Retraction notice: “3,4-Methylenedioxymethamphetamine causes retinal damage in C57BL/6J mice”	15
Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway	15
Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma	14

RETRACTED: Baicalein exerts beneficial effects in lipopolysaccharide-induced pulmonary inflammation by modulating macrophage polarization and inhibiting pyroptosis	14
RETRACTED: Retrospective analysis of the etiology and drugs for vitreous hemorrhage caused by non-diabetic retinopathy and non-traumatic factors	14
The possible cytotoxicity and genotoxicity assessment of indaziflam on HepG2 cells	13
Protective effects of butylated hydroxytoluene on the initiation of N-nitrosodiethylamine-induced hepatocellular carcinoma in albino rats	12
RETRACTED: CircRNA_001373 promotes liver fibrosis by regulating autophagy activation in hepatic stellate cells via the miR-142a-5p/Becn1 axis	12
Neuroinflammatory chemokine networks in transgenic models of Alzheimer’s disease: A comparative multi-compartmental analysis	11
TLR4/ MyD88/NF-κB signaling pathway involved in the protective effect of diacerein against lung fibrosis in rats	11
The effect of melatonin on capecitabine-induced hepatic and renal toxicity in rats	11
Retraction Notice: Association of miR-9-5p and NFIC in the progression of gastric cancer	11
Stevioside inhibits colorectal cancer progression by regulating macrophage polarization	11
Cysteine-rich 61(CYR61) alleviates cyclophosphamide-induced proliferation inhibition in ovarian granulosa cells via suppressing NLRP3/caspase1-mediated pyroptosis	10
RETRACTED: Carvedilol alleviates the detrimental effects of azathioprine on hepatic tissues in experimental rats: Focusing on redox system, inflammatory and apoptosis pathways	10
Anlotinib induces apoptosis and second growth/mitosis phase block in cisplatin-resistant ovarian cancer cells via the aurora kinase A/p53 pathway	10
Trimethylamine-N oxide enhances post-stroke depression progression via ROS-p38/MAPK signaling	10
MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway	10
Assessment of safety through mutagenicity and subchronic toxicity studies with black pepper extract preparation	9
Persistent diazinon induced neurotoxicity: The effect on inhibitory avoidance memory performance, amyloid precursor proteins, and TNF-α levels in the prefrontal cortex of rats	9
Cigarette smoking extract induces mitochondrial dysfunction and apoptosis in HUVECs via the Sirt1-SHH axis	9
Correction to “Corrigendum to effect of grape seed extract ondoxorubicin-induced testicular andepididymal damage in rats”	9
Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment	9
MAPK-interacting kinases inhibition by eFT508 overcomes chemoresistance in preclinical model of osteosarcoma	8
Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis	8
A review of challenges and prospects of 3D cell-based culture models used for studying drug induced liver injury during early phases of drug development	8
Diagnostic and prognostic value of diquat plasma concentration and complete blood count in patients with acute diquat poisoning based on random forest algorithms	8
Retraction notice: “Long noncoding RNA SNHG14 regulates ox-LDL-induced atherosclerosis cell proliferation and apoptosis by targeting miR-186-5p/WIPF2 axis”	8
RETRACTED: Downregulation of miR-138-5p alleviates propofol-induced neurotoxicity and autophagy by regulating SIRT1	8
SEMA3C regulates tumor-associated macrophage phenotype and influences lung cancer cell migration and invasion through VNN1	7
Evaluation of the effectiveness of fresh frozen plasma transfusion as adjuvant treatment in acute organophosphate-poisoned patients: A randomized clinical trial	7
Clinical utility of combined butyrylcholinesterase activity measurements in assessing acute malathion intoxication severity: A case series	7
Environmental contaminants, endocrine disruption, and transgender: Can “born that way” in some cases be toxicologically real?	7
Establishment of a rat model of bronchopulmonary dysplasia complicated with pulmonary hypertension and its potential applications	7
Protective effects of brain and muscle ARNT-like gene 1 on oxidized low-density lipoprotein-induced human brain microvascular endothelial cell injury by alleviating ferroptosis	7
Tricin attenuates diabetic retinopathy by inhibiting oxidative stress and angiogenesis through regulating Sestrin2/Nrf2 signaling	7
Emodin protects against apoptosis and inflammation by regulating reactive oxygen species-mediated NF-κB signaling in interleukin‐1β-stimulated human nucleus pulposus cells	7
Anti-EMT properties of ergothioneine attenuate lipopolysaccharide-induced oxidative stress-mediated acute lung injury via modulating TGF-β/smad/snail signaling pathway	7
Ginsenoside Re suppresses high glucose-induced apoptosis of placental trophoblasts through endoplasmic reticulum stress-related CHOP/GADD153	6
Rhamnazin ameliorates 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-evoked testicular toxicity by restoring biochemical, spermatogenic and histological profile in male albino rats	6
Neurologic disease produced by Rathayibacter toxicus-derived corynetoxins	6
Establishment of an animal model of sciatic nerve injury induced by local anesthetics	6
Omarigliptin/shikonin combination alleviates cyclosporine-induced nephrotoxicity: The role of sirtuin 1, glucagon-like peptide-1, HMGB1/RAGE/TLR4 signaling, and p38/ERK/JNK MAPKs	6
Down-regulation of E2F1 attenuates UVB-induced human lens epithelial cell oxidative stress and pyroptosis through inhibiting NLRP3	6
Discovering the most impactful treatments for aluminum phosphide cardiotoxicity gleaned from systematic review of animal studies	6
Nickel; a metal with threats to human health, focusing on its intoxication mechanisms	6
Nomogram for predicting mechanical ventilation need among acutely intoxicated patients with impaired consciousness: Correspondence	6
Alleviation of the mitochondrial dynamics impairment in doxorubicin-induced cardiomyocyte toxicity by cardioprotective agents	6
Hypoxia-induced autophagy attenuates ferredoxin 1-mediated cuproptosis in colorectal cancer cells	6
Retraction Notice	6
Retraction: Protection by pentoxifylline of malathion-induced toxic stress and mitochondrial damage in rat brain	6
Subchronic inhalation of a novel electronic nicotine delivery system formulation and its corresponding base formulation	6
Retraction Notice	6

Renal glucose transporters play a role in removal of cadmium from kidney cells mediated by GMDTC – A novel metal chelator	6
RETRACTED: Sulforaphane triggers iron overload-mediated ferroptosis in gastric carcinoma cells by activating the PI3K/IRP2/DMT1 pathway	6