OOIR: Observatory of International Research

Papers

(The TQCC of Human & Experimental Toxicology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis	49
Bone marrow mesenchymal stem cells-derived exosomes reduce apoptosis and inflammatory response during spinal cord injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway	39
Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside	34
Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats	32
Protective effects of apigenin on methylmercury-induced behavioral/neurochemical abnormalities and neurotoxicity in rats	30
The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells	30
Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism	30
Arsenic exposure and non-carcinogenic health effects	27
The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats	26
Efficacy of Coccinia grandis against monosodium glutamate induced hepato-cardiac anomalies by inhibiting NF-kB and caspase 3 mediated signalling in rat model	25
Effect of curcumin on lung epithelial injury and ferroptosis induced by cigarette smoke	25
Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma	24
The influence of PM_2.5 exposure on kidney diseases	23
Effect of nano zinc oxide on proliferation and toxicity of human gingival cells	22
Apigenin alleviates methotrexate-induced liver and kidney injury in mice	21
Phillyrin ameliorates diabetic nephropathy through the PI3K/Akt/GSK-3β signalling pathway in streptozotocin-induced diabetic mice	21
Scutellarin alleviates type 2 diabetes (HFD/low dose STZ)-induced cardiac injury through modulation of oxidative stress, inflammation, apoptosis and fibrosis in mice	19
Intravenous lipid emulsion as an adjuvant therapy of acute clozapine poisoning	18
Modulation of cigarette smoke extract-induced human bronchial epithelial damage by eucalyptol and curcumin	18
Quercetin inhibited the proliferation and invasion of hepatoblastoma cells through facilitating SIRT6-medicated FZD4 silence	18
Anti-inflammatory and anti-apoptotic effect of zingiberene on isoproterenol-induced myocardial infarction in experimental animals	18
Rhamnetin alleviates polystyrene microplastics-induced testicular damage by restoring biochemical, steroidogenic, hormonal, apoptotic, inflammatory, spermatogenic and histological profile in male albi	18
The PAD4 inhibitor GSK484 enhances the radiosensitivity of triple-negative breast cancer	17
Icariin inhibits gastric cancer cell growth by regulating the hsa_circ_0003159/miR-223-3p/NLRP3 signaling axis	17
Monosodium glutamate causes hepato-cardiac derangement in male rats	17

Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis	17
Exosomal miR-455-3p from BMMSCs prevents cardiac ischemia-reperfusion injury	16
Early intervention with probiotics and metformin alleviates liver injury in NAFLD rats via targeting gut microbiota dysbiosis and p-AKT/mTOR/LC-3II pathways	16
Quercetin suppresses cell survival and invasion in oral squamous cell carcinoma via the miR-1254/CD36 cascade in vitro	16
Alamandine significantly reduces doxorubicin-induced cardiotoxicity in rats	16
Role of TLR-4/IL-6/TNF-α, COX-II and eNOS/iNOS pathways in the impact of carvedilol against hepatic ischemia reperfusion injury	15
Proteasome inhibitor MG132 induces apoptosis in human osteosarcoma U2OS cells	15
RETRACTED: LncRNA OTUD6B-AS1 inhibits many cellular processes in colorectal cancer by sponging miR-21-5p and regulating PNRC2	15
Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway	15
Synthetic cathinone poisoning from ingestion of drug-laced “instant coffee packets” in Taiwan	14
Gallic acid protects against isoproterenol-induced cardiotoxicity in rats	14
EGFR tyrosine kinase inhibitor Almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non-small cell lung cancer cells	14
Ocular toxicity assessment of nanoemulsion in-situ gel formulation of fluconazole	14
Exosome-derived miR-2682-5p suppresses cell viability and migration by HDAC1-silence-mediated upregulation of ADH1A in non-small cell lung cancer	14
Arsenic trioxide-induced cardiotoxicity triggers ferroptosis in cardiomyoblast cells	13
Betalain exerts cardioprotective and anti-inflammatory effects against the experimental model of heart failure	13
Renoprotective effects of prazosin on ischemia-reperfusion injury in rats	13
Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders	13
Altered expressions of circulating microRNAs 122 and 192 during antitubercular drug induced liver injury indicating their role as potential biomarkers	13
Acetaminophen alleviates ferroptosis in mice with sepsis-associated encephalopathy via the GPX4 pathway	13
Epicatechin ameliorative effects on methotrexate-induced hepatotoxicity in mice	13
Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2	13
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling	13
Machine learning algorithms to predict seizure due to acute tramadol poisoning	13
Ropivacaine represses the ovarian cancer cell stemness and facilitates cell ferroptosis through inactivating the PI3K/AKT signaling pathway	12
Effect of curcumin on the non-alcoholic steatohepatitis via inhibiting the M1 polarization of macrophages	12
Modulation of NRF2/ARE pathway- and cell death-related genes during drug-induced liver injury	12
The role of ferroptosis in organ toxicity	12
Long non-coding RNA SNHG16, binding with miR-106b-5p, promoted cell apoptosis and inflammation in allergic rhinitis by up-regulating leukemia inhibitory factor to activate the JAK1/STAT3 signaling pat	12
FOXM1 regulates the proliferation, apoptosis and inflammatory response of keratinocytes through the NF-κB signaling pathway	12
Synergistic effects of sinapic acid and ellagic acid ameliorate streptozotocin-induced diabetic nephropathy by inhibiting apoptosis, DNA damage, and structural deterioration in rats	12
Gastrodin protects against high glucose-induced cardiomyocyte toxicity via GSK-3β-mediated nuclear translocation of Nrf2	11
Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate in rats	11
Lysine-specific demethylase 1 induced epithelial–mesenchymal transition and promoted renal fibrosis through Jagged-1/Notch signaling pathway	11
Gene expression profiles of transient receptor potential (TRP) channels in the peripheral blood mononuclear cells of psoriasis patients	11
Role of inhibiting Chk1-p53 pathway in hepatotoxicity caused by chronic arsenic exposure from coal-burning	11
Melatonin decreases metastasis, primary tumor growth and angiogenesis in a mice model of breast cancer	11
Kaempferol ameliorates palmitate-induced lipid accumulation in HepG2 cells through activation of the Nrf2 signaling pathway	11
Solasonine relieves sevoflurane-induced neurotoxicity via activating the AMP-activated protein kinase/FoxO3a pathway	11
Metabolic profiling of 19 amino acids in triptolide-induced liver injured rats by gas chromatography-triple quadrupole mass spectrometry	11
RETRACTED: LncRNA MIAT regulated by selenium and T-2 toxin increases NF-κB-p65 activation, promoting the progress of Kashin-Beck Disease	11
Carvacrol hinders the progression of hepatic fibrosis via targeting autotaxin and thioredoxin in thioacetamide-induced liver fibrosis in rat	11
Gallic acid ameliorates di-(2-ethylhexyl) phthalate-induced testicular injury in adult mice	11
Hepatoprotective effect of ferulic acid and/or low doses of γ-irradiation against cisplatin-induced liver injury in rats	11
Simvastatin cardioprotection in cyclophosphamide-induced toxicity via the modulation of inflammasome/caspase1/interleukin1β pathway	11
Perinatal exposure to di-(2-ethylhexyl) phthalate induces hepatic lipid accumulation mediated by diacylglycerol acyltransferase 1	11
Toxic mechanisms of cadmium and exposure as a risk factor for oral and gastrointestinal carcinomas	11
LINC00265 promotes the viability, proliferation, and migration of bladder cancer cells via the miR-4677-3p/FGF6 axis	10
Hexagonal boron nitride nanoparticles trigger oxidative stress by modulating thiol/disulfide homeostasis	10
Notoginsenoside R1 protects hypoxia-reoxygenation deprivation-induced injury by upregulation of miR-132 in H9c2 cells	10

Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice	10
MiR-200c-3p regulates pyroptosis by targeting SLC30A7 in diabetic retinopathy	10
Subacute melamine exposure disrupts task-based hippocampal information flow via inhibiting the subunits 2 and 3 of AMPA glutamate receptors expression	10
Ephedrine attenuates cerebral ischemia/reperfusion injury in rats through NF-κB signaling pathway	10
Mitigation of IL-1β, IL-6, TNF-α, and markers of apoptosis by ursolic acid against cisplatin-induced oxidative stress and nephrotoxicity in rats	10
Idebenone regulates sirt1/Nrf2/TNF-α pathway with inhibition of oxidative stress, inflammation, and apoptosis in testicular torsion/detorsion in juvenile rats	10
The effect of baicalein on endoplasmic reticulum stress and autophagy on liver damage	10
The effects of subconjunctival bevacizumab, ranibizumab, and aflibercept on corneal neovascularization	10
LncRNA PART1 promotes lung squamous cell carcinoma progression via miR-185-5p/Six1 axis	10
Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress	10
Ameliorative effect of herbacetin against cyclophosphamide-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction	10
Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring	10
Protective effect of D-(−)-quinic acid as food supplement in modulating AMP-activated protein kinase signalling pathway activation in HFD induced obesity	10
MicroRNA-26b-5p alleviates cerebral ischemia-reperfusion injury in rats via inhibiting the N-myc/PTEN axis by downregulating KLF10 expression	10
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway	10
Tricin attenuates diabetic retinopathy by inhibiting oxidative stress and angiogenesis through regulating Sestrin2/Nrf2 signaling	10
A comparative assessment of e-cigarette aerosol extracts and tobacco cigarette smoke extracts on in vitro endothelial cell inflammation response	9
In vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavone	9
Ephedrine ameliorates cerebral ischemia injury via inhibiting NOD-like receptor pyrin domain 3 inflammasome activation through the Akt/GSK3β/NRF2 pathway	9
Taraxasterol inhibits TGF-β1-induced epithelial-to-mesenchymal transition in papillary thyroid cancer cells through regulating the Wnt/β-catenin signaling	9
Taraxasterol attenuates melanoma progression via inactivation of reactive oxygen species-mediated PI3K/Akt signaling pathway	9
Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway	9
Chemopreventive effect of galangin against benzo(a)pyrene-induced stomach tumorigenesis through modulating aryl hydrocarbon receptor in Swiss albino mice	9
Protective effects of zingerone on high cholesterol diet-induced atherosclerosis through lipid regulatory signaling pathway	9
CTRP3 protects hippocampal neurons from oxygen-glucose deprivation-induced injury through the AMPK/Nrf2/ARE pathway	9
Effect of taxifolin/dapagliflozin combination on colistin-induced nephrotoxicity in rats	9
Protective effect of pyrrolidine dithiocarbamate against methotrexate-induced testicular damage	9
Triptolide regulates oxidative stress and inflammation leading to hepatotoxicity via inducing CYP2E1	9
Assessment of oxidative DNA damage, oxidative stress responses and histopathological alterations in gill and liver tissues of Oncorhynchus mykiss treated with linuron	8
Comparing the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning using predictive biomarkers and scores: A randomized controlled clinical trial	8
Tricin attenuates cerebral ischemia/reperfusion injury through inhibiting nerve cell autophagy, apoptosis and inflammation by regulating the PI3K/Akt pathway	8
Acrylamide impairs the developmental potential of germinal vesicle oocytes by inducing mitochondrial dysfunction and autophagy/apoptosis in mice	8
Inhibition of SET domain–containing (lysine methyltransferase) 7 alleviates cognitive impairment through suppressing the activation of NOD-like receptor protein 3 inflammasome in isoflurane-induced ag	8
Resveratrol reverses the cadmium-promoted migration, invasion, and epithelial–mesenchymal transition procession by regulating the expression of ZEB1	8
Thymoquinone supplementation ameliorates cisplatin-induced hepatic pathophysiology	8
Sevoflurane Postconditioning Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting SP1/ACSL4-Mediated Ferroptosis	8
RETRACTED: Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway	8
Nicotinamide improves NAD⁺ levels to protect against acetaminophen-induced acute liver injury in mice	8
Notoginsenoside R2 reduces Aβ25-35-induced neuronal apoptosis and inflammation via miR-27a/SOX8/β-catenin axis	8
Ginkgolic acid induces apoptosis and autophagy of endometrial carcinoma cells via inhibiting PI3K/Akt/mTOR pathway in vivo and in vitro	8
Protective effects of necrostatin-1 on doxorubicin-induced cardiotoxicity in rat heart	8
Electrocardiographic, hemodynamic, and biochemical evidence on the protective effects of exenatide against phosphine-induced cardiotoxicity in rat model	7
Indole-3-carbinol inhibits the proliferation of colorectal carcinoma LoVo cells through activation of the apoptotic signaling pathway	7
Pediatric allergic rhinitis with functional gastrointestinal disease: Associations with the intestinal microbiota and gastrointestinal peptides and therapeutic effects of interventions	7
Myricetin (3,3^′,4^′,5,5^′,7-hexahydroxyflavone) prevents ethanol-induced biochemical and inflammatory damage in the liver of Wistar rats	7
Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary	7
Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats	7
Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions Androctonus mauretanicus and Buthus occitanus: A comparative pathophysiological and toxic-sy	7
Phosphodiesterase inhibitor, Vinpocetine, guards against doxorubicin induced cardiotoxicity via modulation of HIF/VEGF and cGMP/cAMP/SIRT signaling pathways	7
Androgen receptor suppresses inflammatory response of airway epithelial cells in allergic asthma through MAPK1 and MAPK14	7
Heavy metal and essential elements in beers from turkey market: A risk assessment study	7
Dental amalgam fillings and mercury vapor safety limits in American adults	7
Protective effects of Gamma Oryzanol on distant organs after kidney ischemia-reperfusion in rats: A focus on liver protection	7
Emodin protects against apoptosis and inflammation by regulating reactive oxygen species-mediated NF-κB signaling in interleukin‐1β-stimulated human nucleus pulposus cells	7
Resolvin D1 protects against cadmium chloride-induced memory loss and hippocampal damage in rats: A comparison with docosahexaenoic acid	7
Lipid emulsions attenuate the inhibition of carnitine acylcarnitine translocase induced by toxic doses of local anesthetics in rat cardiomyoblasts	7
Antidiabetic effects of nerolidol through promoting insulin receptor signaling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats	7
Toxicity assessment of gelsenicine and the search for effective antidotes	7
Effects of psoralen on hepatic bile acid transporters in rats	7
Albiflorin ameliorates mesangial proliferative glomerulonephritis by PI3K/AKT/NF-κB pathway	7
Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3β modulation	7
Effects of Shenfu injection on myocardial adenosine receptors in rats with myocardial ischemia-reperfusion postconditioning	7
Molecular perspective concerning fluoride and arsenic mediated disorders on epididymal maturation of spermatozoa: A concise review	7
Curcumin decreases dibutyl phthalate-induced renal dysfunction in Kunming mice via inhibiting oxidative stress and apoptosis	7
Role of the AMPK signalling pathway in the aetiopathogenesis of ocular diseases	7
Gallic acid inhibits celecoxib-induced mitochondrial permeability transition and reduces its toxicity in isolated cardiomyocytes and mitochondria	7
Irigenin attenuates lipopolysaccharide-induced acute lung injury by inactivating the mitogen-activated protein kinase (MAPK) signaling pathway	7
Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties	7
Vinpocetine attenuates fluoxetine-induced liver damage in rats; Role of Nrf2 and PPAR-γ	7
Kaempferol inhibits airway inflammation induced by allergic asthma through NOX4-Mediated autophagy	7
Shenfu Administration Improves Cardiac Fibrosis in Rats With Myocardial Ischemia-Reperfusion Through Adenosine A_2a Receptor Activation	7