Human & Experimental Toxicology

Article	Citations
Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma	65
LINC00641 impeded the malignant biological behaviors of papillary thyroid carcinoma cells via interacting with IGF2BP1 to reduce GLI1 mRNA stability	46
Prenatal and early life lead exposure induced neurotoxicity	41
Silver nanoparticles trigger delayed inflammatory responses in mast cells	31
Sevoflurane preconditioning attenuates myocardial cell damage caused by hypoxia and reoxygenation via regulating the NORAD/miR-144-3p axis	30
Development and validation of a novel poisoning agitation-sedation score for predicting the need for endotracheal intubation and mechanical ventilation in acutely poisoned patients with disturbed cons	28
Oxidative stress reactions in rats with pulmonary injuries induced by sulfur mustard (1 LD50)	27
Exploring the utility of zinc finger protein-related genes in predicting hepatocellular carcinoma prognosis, immune responses, and drug efficacy	24
Retraction Notice: “Sulforaphane triggers iron overload-mediated ferroptosis in gastric carcinoma cells by activating the PI3K/IRP2/DMT1 pathway”	21
Effects of doxorubicin on autophagy in fibroblasts	20
Human health risk assessment of heavy metals in different compartments of vegetables from Erbil City-Iraq	19
Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro	19
LINC00294/miR-620/MKRN2 axis provides biomarkers and negatively regulates malignant progression in colorectal carcinoma	19
Effects of methylphenidate on femoral bone growth in male rats	19
Acriflavine protects against LPS-induced sepsis via regulation of pyroptosis, inflammation, and endoplasmic reticulum stress	18
Retraction Notice	18
Effects of polycyclic aromatic hydrocarbon exposure on mitochondrial DNA copy number	17
Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders	17
Relationship between clock gene expression and CYP2C19 and CYP3A4 with benzodiazepines	16
RETRACTED: Ginsenoside Rg5 induces NSCLC cell apoptosis and autophagy through PI3K/Akt/mTOR signaling pathway	16
Exosomes derived from M2 macrophages promote fibroblast autophagy to contribute to hypertrophic scar formation via CXCL2/CXCR7/mTOR pathway	16
Clinical characteristics and the risk factors analysis in patients with delayed encephalopathy after acute carbon monoxide poisoning	16
Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway	15
Retraction notice: “3,4-Methylenedioxymethamphetamine causes retinal damage in C57BL/6J mice”	15
RETRACTED: Baicalein exerts beneficial effects in lipopolysaccharide-induced pulmonary inflammation by modulating macrophage polarization and inhibiting pyroptosis	14

RETRACTED: Retrospective analysis of the etiology and drugs for vitreous hemorrhage caused by non-diabetic retinopathy and non-traumatic factors	14
Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma	14
The possible cytotoxicity and genotoxicity assessment of indaziflam on HepG2 cells	13
RETRACTED: CircRNA_001373 promotes liver fibrosis by regulating autophagy activation in hepatic stellate cells via the miR-142a-5p/Becn1 axis	12
Protective effects of butylated hydroxytoluene on the initiation of N-nitrosodiethylamine-induced hepatocellular carcinoma in albino rats	12
TLR4/ MyD88/NF-κB signaling pathway involved in the protective effect of diacerein against lung fibrosis in rats	11
The effect of melatonin on capecitabine-induced hepatic and renal toxicity in rats	11
Retraction Notice: Association of miR-9-5p and NFIC in the progression of gastric cancer	11
Stevioside inhibits colorectal cancer progression by regulating macrophage polarization	11
Neuroinflammatory chemokine networks in transgenic models of Alzheimer’s disease: A comparative multi-compartmental analysis	11
Anlotinib induces apoptosis and second growth/mitosis phase block in cisplatin-resistant ovarian cancer cells via the aurora kinase A/p53 pathway	10
Trimethylamine-N oxide enhances post-stroke depression progression via ROS-p38/MAPK signaling	10
MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway	10
Cysteine-rich 61(CYR61) alleviates cyclophosphamide-induced proliferation inhibition in ovarian granulosa cells via suppressing NLRP3/caspase1-mediated pyroptosis	10
RETRACTED: Carvedilol alleviates the detrimental effects of azathioprine on hepatic tissues in experimental rats: Focusing on redox system, inflammatory and apoptosis pathways	10
Assessment of safety through mutagenicity and subchronic toxicity studies with black pepper extract preparation	9
Persistent diazinon induced neurotoxicity: The effect on inhibitory avoidance memory performance, amyloid precursor proteins, and TNF-α levels in the prefrontal cortex of rats	9
Cigarette smoking extract induces mitochondrial dysfunction and apoptosis in HUVECs via the Sirt1-SHH axis	9
Correction to “Corrigendum to effect of grape seed extract ondoxorubicin-induced testicular andepididymal damage in rats”	9
Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment	9
MAPK-interacting kinases inhibition by eFT508 overcomes chemoresistance in preclinical model of osteosarcoma	8
Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis	8
A review of challenges and prospects of 3D cell-based culture models used for studying drug induced liver injury during early phases of drug development	8
Diagnostic and prognostic value of diquat plasma concentration and complete blood count in patients with acute diquat poisoning based on random forest algorithms	8
Retraction notice: “Long noncoding RNA SNHG14 regulates ox-LDL-induced atherosclerosis cell proliferation and apoptosis by targeting miR-186-5p/WIPF2 axis”	8
RETRACTED: Downregulation of miR-138-5p alleviates propofol-induced neurotoxicity and autophagy by regulating SIRT1	8
Clinical utility of combined butyrylcholinesterase activity measurements in assessing acute malathion intoxication severity: A case series	7
Environmental contaminants, endocrine disruption, and transgender: Can “born that way” in some cases be toxicologically real?	7
Establishment of a rat model of bronchopulmonary dysplasia complicated with pulmonary hypertension and its potential applications	7
Protective effects of brain and muscle ARNT-like gene 1 on oxidized low-density lipoprotein-induced human brain microvascular endothelial cell injury by alleviating ferroptosis	7
Tricin attenuates diabetic retinopathy by inhibiting oxidative stress and angiogenesis through regulating Sestrin2/Nrf2 signaling	7
Emodin protects against apoptosis and inflammation by regulating reactive oxygen species-mediated NF-κB signaling in interleukin‐1β-stimulated human nucleus pulposus cells	7
Anti-EMT properties of ergothioneine attenuate lipopolysaccharide-induced oxidative stress-mediated acute lung injury via modulating TGF-β/smad/snail signaling pathway	7
SEMA3C regulates tumor-associated macrophage phenotype and influences lung cancer cell migration and invasion through VNN1	7
Evaluation of the effectiveness of fresh frozen plasma transfusion as adjuvant treatment in acute organophosphate-poisoned patients: A randomized clinical trial	7
Omarigliptin/shikonin combination alleviates cyclosporine-induced nephrotoxicity: The role of sirtuin 1, glucagon-like peptide-1, HMGB1/RAGE/TLR4 signaling, and p38/ERK/JNK MAPKs	6
Down-regulation of E2F1 attenuates UVB-induced human lens epithelial cell oxidative stress and pyroptosis through inhibiting NLRP3	6
Discovering the most impactful treatments for aluminum phosphide cardiotoxicity gleaned from systematic review of animal studies	6
Nickel; a metal with threats to human health, focusing on its intoxication mechanisms	6
Nomogram for predicting mechanical ventilation need among acutely intoxicated patients with impaired consciousness: Correspondence	6
Alleviation of the mitochondrial dynamics impairment in doxorubicin-induced cardiomyocyte toxicity by cardioprotective agents	6
Hypoxia-induced autophagy attenuates ferredoxin 1-mediated cuproptosis in colorectal cancer cells	6
Retraction Notice	6
Retraction: Protection by pentoxifylline of malathion-induced toxic stress and mitochondrial damage in rat brain	6
Subchronic inhalation of a novel electronic nicotine delivery system formulation and its corresponding base formulation	6
Retraction Notice	6
Renal glucose transporters play a role in removal of cadmium from kidney cells mediated by GMDTC – A novel metal chelator	6
RETRACTED: Sulforaphane triggers iron overload-mediated ferroptosis in gastric carcinoma cells by activating the PI3K/IRP2/DMT1 pathway	6
Ginsenoside Re suppresses high glucose-induced apoptosis of placental trophoblasts through endoplasmic reticulum stress-related CHOP/GADD153	6
Rhamnazin ameliorates 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-evoked testicular toxicity by restoring biochemical, spermatogenic and histological profile in male albino rats	6

Neurologic disease produced by Rathayibacter toxicus-derived corynetoxins	6
Establishment of an animal model of sciatic nerve injury induced by local anesthetics	6
Corrigendum to “Apoptosis-promoting and migration-suppressing effect of alantolactone on gastric cancer cell lines BGC-823 and SGC-7901 via regulating p38MAPK and NF-κB pathways”	5
Targeted inhibition of STING-TBK1 axis alleviates the hepatotoxicity of tripterygium glycosides	5
Clinical and laboratory prognostic factors associated with methanol toxicity outcomes in patients at Tabriz Sina Hospital: A retrospective study	5
Evaluation of Cd-induced cytotoxicity in primary human keratinocytes	5
Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties	5
Water-soluble Yb3+, Er3+ codoped NaYF4 nanoparticles induced SGC-7901 cell apoptosis through mitochondrial dysfunction and ROS-mediated ER stress	5
Retraction Notice	5
CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer	5
Corrigendum to “Diagnostic and prognostic value of diquat plasma concentration and complete blood count in patients with acute diquat poisoning based on random forest algorithms”	5
RNA-seq analysis revealed genes associated with neuropathic pain induced by chronic compressive injury in interferon regulatory factors 4 knockout mice	5
Alkylating agents are possible inducers of glioblastoma and other brain tumors	5
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury	5
RETRACTED: Arsenic-induced downregulation of BRWD3 suppresses proliferation and induces apoptosis in lung adenocarcinoma cells through the p53 and p65 pathways	4
High-dose vitamin C potently induces apoptosis in acute lymphoblastic leukemia by activating ER stress response	4
Ginkgolide A downregulates transient receptor potential (melastatin) 2 to protect cisplatin-induced acute kidney injury in rats through the TWEAK/Fn14 pathway: Ginkgolide A improve acute renal injury	4
Comparing the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning using predictive biomarkers and scores: A randomized controlled clinical trial	4
Effect of grape seed extract on doxorubicin-induced testicular and epididymal damage in rats	4
Ergot alkaloid consumption alters serotonin receptor-induced vasoactivity in ovine umbilical vasculature	4
MG132 inhibits proliferation and induces apoptosis of acute lymphoblastic leukemia via Akt/FOXO3a/Bim pathway	4
KLF9 mediates NLRP3 inflammasome and reactive oxygen species to mediate pyroptosis in trophoblasts	4
Integrated gut microbiota and serum metabolomics reveal glyphosate-induced hepatic injury in mice	4
The effects of esketamine on the intestinal microenvironment and intestinal microbiota in mice	4
Hepatoprotective potential of diosmin against hepatotoxic effect of isoniazid and rifampin in wistar rats	4
Potential induction of hyperkeratosis in rats’ cervi by gentamicin via induction of oxidative stress, inflammation and apoptosis	4
Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis	4
Pelargonidin-3-O-glucoside prevents isoproterenol-induced myocardial infarction via modulating cardiac and inflammatory markers expression in experimental rats	4
Mechanism of triiodothyronine alleviating acute alcoholic liver injury and delaying alcoholic liver fibrosis progression	4
Stereotactic body radiation therapy suppresses myeloid-derived suppressor cells by regulating miR-21/Sorbin and SH3 Domain-containing Protein 1 axis	4
Dexmedetomidine and propofol-induced neurotoxicity: Promise, but caution warranted	4
Follow-up of patients with a 5-year survival after paraquat poisoning using computed tomography images and spirometry	4
RETRACTED: Comparative analysis of noise and music exposure on inflammatory responses on lipopolysaccharide-induced septic rats	4
Curculigoside attenuates cerebral ischemia-reperfusion injury via TRPM2-mediated microglial polarization	4
Acrylamide-induced meiotic arrest of spermatocytes in adolescent mice by triggering excessive DNA strand breaks: Potential therapeutic effects of resveratrol	4
The acute and sub-chronic toxicological effects of 3-amino-9-ethylcarbazole (AEC) on zebrafish	3
Relationship between the start time of treatment and patient prognosis in cases of acute wild mushroom poisoning in a certain region of Guizhou Province, China from 2013 to 2020: A retrospective Obser	3
Effects of combined exposure of manganese and iron on serum inflammatory factor levels among workers	3
Problems with the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning	3
Physalin A induces apoptosis through conjugating with Fas-FADD cell death receptor in human oral squamous carcinoma cells and suppresses HSC-3 cell xenograft tumors in NOD/SCID mice	3
Association between serum complement 1q and the associated factors of acute ischemic stroke in patients with type 2 diabetes	3
Preclinical Evaluation of interferon-gamma primed human Wharton’s jelly-derived mesenchymal stem cells	3
Retraction Notice	3
Performance assessment of new Poisoning Mortality Score and PGI score for predicting mortality in patients with acute aluminum phosphide poisoning	3
Liver and ovarian toxicities boosted by bisphenol and gamma radiation in female albino rats	3
Insights into therapeutic potential and practical applications of natural toxins from poisonous mushrooms	3
Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice	3
Punicalagin is cytotoxic to human colon cancer cells by modulating cell proliferation, apoptosis, and invasion	3
Retraction: Protective effects of casein-derived peptide VLPVPQK against hydrogen peroxide-induced dysfunction and cellular oxidative damage in rat osteoblastic cells	3
Wasp-stung rat model translationally expresses the coagulopathy manifestations of human wasp patients	3
An artificial intelligence algorithm for analyzing globus pallidus necrosis after carbon monoxide intoxication	3
Glutathione S-transferase zeta 1 alters the HMGB1/GPX4 axis to drive ferroptosis in bladder cancer cells	3
In silico evaluations of phytochemicals from Withania somnifera exhibiting anticancer activity against NAD[P]H-quinone oxidoreductase	3
Development and validation of a nomogram for predicting mechanical ventilation need among acutely intoxicated patients with impaired consciousness	3
Conflicts of interest in the International Agency for Research on Cancer process of identifying carcinogenic hazards to humans	3
Histological and immunohistochemical alterations in the brain tissues induced by the subchronic toxicity of gold nanoparticles: In vivo study	3
Mechanism of action of curcumin targeting TRPM2/NLRP3 signaling axis to mediate cell death in the treatment of knee osteoarthritis	2
Prenatal cyanuric acid exposure induced spatial learning impairments associated with alteration of acetylcholine-mediated neural information flow at the hippocampal CA3-CA1 synapses of male rats	2
Enhancing breast cancer treatment: Evaluating the efficacy of hyaluronic acid-coated tamoxifen-loaded solid lipid nanoparticles on MCF7 cells	2
Luteolin alleviates cyclophosphamide-induced premature ovarian failure in rats by regulating RNF8/HDAC2	2
Expression of concern	2
Evaluation of mixtures of flavor chemicals in a 90-day nose-only exposures in sprague-dawley rats	2
Bardoxolone methyl triggers Ferroptosis in cardiomyocytes	2
Biological function of C-X-C Motif Chemokine Ligand 1 gene (CXCL1) in ovarian malignant tumors	2
Protective effects of Tribulus Terrestris extract on cisplatin-induced ovarian damage: Antioxidants and anti-inflammatory insights	2
Predictive factors of severe outcome in glufosinate ammonium poisoning: A retrospective study in Vietnam	2
Effects of detergent component sodium dodecyl sulfate on growth hormone secretion in GH3 cells: Implications for pediatric exposure and accidental ingestion	2
Tanshinone I induces ferroptosis in gastric cancer cells via the KDM4D/p53 pathway	2
Exploring the role of rare earth elements (praseodymium, samarium, lanthanum, and terbium) and oxidative stress in polycystic ovary syndrome: A case-control study	2
Sevoflurane Postconditioning Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting SP1/ACSL4-Mediated Ferroptosis	2
Corrigendum	2
Retraction Notice	2
Network pharmacology and experimental verification: Unraveling Zhiwei Fuwei Pills’s role and mechanism in angiogenesis of precancerous lesions of gastric cancer	2
Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5‘-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling	2
Assessment of acute and subchronic skin toxicity of drilling fluids	2
KLF6 silencing attenuates MCAO-induced brain injury and cognitive dysfunction via targeting ferroptosis and activating the Nrf2/HO-1 pathway	2
Microsomal glutathione S-transferase 1 targets the autophagy signaling pathway to suppress ferroptosis in gastric carcinoma cells	2
Protocatechuic acid mitigates 5-fluorouracil-triggered renal and hepatic injury in rats	2
The role of SIRT1/PGC1-α signaling pathway in high-dose vitamin D-Induced cardiotoxicity	2
Corrigendum to “Reassessing clinical presentations of emamectin benzoate poisoning: A comprehensive study”	2

Iron; Benefits or threatens (with emphasis on mechanism and treatment of its poisoning)	2
Risk factors for glioblastoma are shared by other brain tumor types	2
RETRACTED: LncRNA-NEAT1 facilitates autophagy to boost pemetrexed resistance in lung adenocarcinoma via the mir-379-3p/HIF1A pathway	2
Reactive oxygen species-mediated epidermal stress in human keratinocytes under dual exposure to blue light and heated tobacco product	2
Impact of combined chronic exposure to low-dose bisphenol A and fructose on serum adipocytokines and the energy target metabolome in white adipose tissue	2
Nifuroxazide attenuated 5-fluorouracil-induced cardiac intoxication by regulating NLRP3/STAT-3, PPAR-γ, and apoptosis signals	2
Withdrawn—Administrative Error: “Corrigendum to ‘Carvedilol alleviates the detrimental effects of azathioprine on hepatic tissues in experimental rats: Focusing on redox system, inflammatory and apopt	2
Retraction Notice	2
Integrative analysis of renal microRNA and mRNA to identify hub genes and pivotal pathways associated with cyclosporine-induced acute kidney injury in mice	2