OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Genetics & Development is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Editorial Board	52
Editorial Board	52
Editorial Board	51
Why is measuring and predicting fitness under genomic conflict so hard?	45
The X chromosome in C. elegans sex determination and dosage compensation	43
Editorial overview: Conflicts, conflicts everywhere	43
Integrative approaches to study enhancer–promoter communication	42
R-loops in neurodegeneration	41
Tile by tile: capturing the evolutionary mosaic of human conditions	37
Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation	36
A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation	36
Epithelial–immune crosstalk in health and disease	36
Evolution and ecology of commensal gut protists: recent advances	34
Adipose tissue endothelial cells: insights into their heterogeneity and functional diversity	33
Break-induced replication mechanisms in yeast and mammals	32
DNA end resection during homologous recombination	31
Editorial Board	30
In vitro models of pre- and post-gastrulation embryonic development	29
Therapeutic strategies to target the epitranscriptomic machinery	29
Epigenetic memory in reprogramming	27
Interplay between N-adenosine RNA methylation and mRNA splicing	27
Genetic clues to reprogramming power and formation of mouse oocyte	27
Toward the dissection of hematopoietic stem cell fates and their determinants	27
Control of cell fate upon transcription factor–driven cardiac reprogramming	27
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate	26

Cell–cell interactions between transplanted retinal organoid cells and recipient tissues	26
NAT10 and cytidine acetylation in mRNA: intersecting paths in development and disease	26
Exploring the origin of the development: totipotent stem cells	26
High-throughput approaches to functional characterization of genetic variation in yeast	26
Using human pluripotent stem cells to dissect trophoblast development	25
Single-cell genomic profiling to study regeneration	25
Reprogramming lineage identity through cell–cell fusion	25
Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders	24
If you please, draw me a neuron — linking evolutionary tinkering with human neuron evolution	24
Genome instability in mammalian embryos implications for genome editing, development, and evolution	24
Recombination-mediated genome rearrangements	24
Structural variation in humans and our primate kin in the era of telomere-to-telomere genomes and pangenomics	23
How strand exchange protein function benefits from ATP hydrolysis	23
Transposon waves at the water-to-land transition	22
Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing	22
Adipose tissue-derived lipokines in metabolism	22
Stem-cell-based human and mouse embryo models	21
Dynamic microenvironments shape nuclear organization and gene expression	20
Better together: how cooperativity influences transcriptional bursting	20
Molecular genetics of pulmonary hypertension in children	20
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium	19
Editorial overview: Drivers, droplets, and deeds of nuclear genome organization	19
Nuclear remodeling during cell fate transitions	19
Modifying gastruloids to dissect mechanisms of tissue-specific induction	19
Editorial overview: Recombination — the ends justify the means	19
Linking phenotype to genotype using comprehensive genomic comparisons	19
Editorial overview: Multiscale regulation of genome folding in space, time, and across the tree of life	19
Digesting the mechanobiology of the intestinal epithelium	18
Recipes and ingredients for deep learning models of 3D genome folding	18
Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?	18
Multi-organelle-mediated mRNA localization in neurons and links to disease	17
The Yin and Yang of replicative aging and rejuvenation	17
Enhancers on the edge — how the nuclear envelope controls gene regulatory elements	17
A haystack in the needle: packaging sperm DNA in insects	17
Biological roles of nonsense-mediated RNA decay: insights from the nervous system	17
Human 8-cell embryo-like cells from pluripotent stem cells	17
Editorial overview: Peering into our history through a genetic lens: How advances in genetics are changing our understanding of human evolution	17
Meiotic drive of noncentromeric loci in mammalian meiosis II eggs	16
What are tethering elements?	16
Epigenetic priming in the male germline	16
RNA interference therapeutics for cardiac regeneration	16
Evolution of 3D chromatin organization at different scales	16
Shaping inheritance: how distinct reproductive strategies influence DNA methylation memory in plants	15
Approaches to probe and perturb long noncoding RNA functions in diseases	15
Maternal genetic factors in the development of congenital heart defects	15
Songbird germline-restricted chromosome as a potential arena of genetic conflicts	14
DNA helicases in homologous recombination repair	14
Rewiring cancer: 3D genome determinants of cancer hallmarks	14
Editorial Board	14
Advances in skeletal genomics research across tissues and cells	14

Cancer-associated chromatin variants uncover the oncogenic role of transposable elements	14
Editorial overview: Epigenetic inheritance: A shortcut to environmental adaptation?	14
Chromatin architecture reorganization during somatic cell reprogramming	14
Transposable elements in early human embryo development and embryo models	14
Inheritance of epigenetic transcriptional memory	14
Cell identity conversion in liver regeneration after injury	14
Cellular plasticity in the neural crest and cancer	13
A new era of understanding in vivo metabolic flux in thermogenic adipocytes	13
Architecture of RNA–RNA interactions	13
Discrete roles for Rad54 and Rdh54 during homologous recombination	13
Amending the injured heart by in vivo reprogramming	13
Correlation between protein abundance and sequence conservation: what do recent experiments say?	13
Adipose tissue lipid metabolism: lipolysis	13
Editorial Board	13
Editorial overview: Regaining architecture and cell cross-talk upon regeneration	13
Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations	13
Editorial overview: The genome in space–time	13
Deciphering microglia phenotypes in health and disease	13
Editorial overview: Epitranscriptomics: Exploring a new frontier in health and disease	13
Recent developments in adipose tissue-secreted factors and their target organs	12
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes	12
Brain organoids: the quest to decipher human-specific features of brain development	12
Cellular identity through the lens of direct lineage reprogramming	12
Toward a comprehensive view of gene architecture during transcription	12
Evolution and molecular bases of reproductive isolation	12
The stem cell zoo for comparative studies of developmental tempo	12
Principles of genome activation in the early embryo	12
Editorial Board	12
Genome folding dynamics during the M-to-G1-phase transition	11
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer	11
An extending ATR–CHK1 circuitry: the replication stress response and beyond	11
Transcriptional regulation of T cell metabolism and metabolic control of T cell gene expression	11
Polycomb complexes in MLL–AF9-related leukemias	11
Phase separation and inheritance of repressive chromatin domains	11
The role of loop extrusion in enhancer-mediated gene activation	11
Exploring conditional gene essentiality through systems genetics approaches in yeast	11
Microbial experimental evolution in a massively multiplexed and high-throughput era	11
3D chromosomal architecture in germinal center B cells and its alterations in lymphomagenesis	11
In vitro models of human hypoblast and mouse primitive endoderm	11
Editorial Board	11
Reconstitution of reproductive organ system that produces functional oocytes	11
Alternative splicing in addiction	11
Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks	11
Bridging spatial and temporal scales of developmental gene regulation	11
Epistasis and evolutionary dependencies in human cancers	11
Editorial Board	11
When 3D genome changes cause disease: the impact of structural variations in congenital disease and cancer	11
The role of SAF-A/hnRNP U in regulating chromatin structure	11
Dissecting nephron morphogenesis using kidney organoids from human pluripotent stem cells	11