OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Genetics & Development is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Enhancer-promoter communication: hubs or loops?	109
To loop or not to loop: what is the role of TADs in enhancer function and gene regulation?	66
Spatially resolved transcriptomics and its applications in cancer	64
Role of VPS13, a protein with similarity to ATG2, in physiology and disease	56
Evolution of sexual development and sexual dimorphism in insects	55
Copy number variation and neuropsychiatric illness	52
16p11.2 deletion syndrome	51
Diverse lncRNA mechanisms in brain development and disease	49
Single-molecule tracking of transcription protein dynamics in living cells: seeing is believing, but what are we seeing?	48
Advances in colon cancer research: in vitro and animal models	44
Regulation of 3D chromatin organization by CTCF	43
Evolution of pigment cells and patterns: recent insights from teleost fishes	40
Microexons: at the nexus of nervous system development, behaviour and autism spectrum disorder	39
Nuclear mechanisms of gene expression control: pre-mRNA splicing as a life or death decision	39
The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases	38
4D nucleome modeling	37
Structure-forming repeats and their impact on genome stability	37
The evolution of the human brain and disease susceptibility	35
Poison exons in neurodevelopment and disease	35
Microglial ontogeny, diversity and neurodevelopmental functions	35
Advances in repeat expansion diseases and a new concept of repeat motif–phenotype correlation	34
The evolution of structural colour in butterflies	34
Active nematics across scales from cytoskeleton organization to tissue morphogenesis	33
DNA end resection during homologous recombination	32
Diagnostic genetic testing for neurodevelopmental psychiatric disorders: closing the gap between recommendation and clinical implementation	32

The shifting shape of genomes: dynamics of heterochromatin interactions at the nuclear lamina	31
New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders	31
Extrachromosomal DNA (ecDNA) in cancer pathogenesis	31
The nuclear pore complex and the genome: organizing and regulatory principles	30
Break-induced replication mechanisms in yeast and mammals	30
An extending ATR–CHK1 circuitry: the replication stress response and beyond	29
The transcription factor code in iPSC reprogramming	28
Activity regulates brain development in the fly	28
The evolution of post-translational modifications	27
Disentangling the paradox of the PCDH19 clustering epilepsy, a disorder of cellular mosaics	26
The stochastic nature of genome organization and function	26
Exosomes in cancer development	26
Genetic pathways involved in human speech disorders	25
Mechanisms of maternal intergenerational epigenetic inheritance	24
LINC complex regulation of genome organization and function	24
Cortico-basal ganglia circuits underlying dysfunctional control of motor behaviors in neuropsychiatric disorders	24
The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization	23
Insights into clonal hematopoiesis and its relation to cancer risk	23
The role of SAF-A/hnRNP U in regulating chromatin structure	23
Digesting the mechanobiology of the intestinal epithelium	23
Evo-devo of shell colour in gastropods and bivalves	22
H3–H4 histone chaperones and cancer	22
Mitotic recombination in yeast: what we know and what we don’t know	22
How gene duplication diversifies the landscape of protein oligomeric state and function	22
The role of somatic mosaicism in brain disease	22
The role of loop extrusion in enhancer-mediated gene activation	22
Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function	21
Distinct fibroblasts in scars and regeneration	21
Serine ADP-ribosylation in DNA-damage response regulation	21
The dawn of non-human primate models for neurodevelopmental disorders	21
Molecular mechanisms for targeted ASD treatments	21
Noncanonical imprinting: intergenerational epigenetic inheritance mediated by Polycomb complexes	21
Recombination and restart at blocked replication forks	20
Homologous recombination within repetitive DNA	20
RAD51 paralog function in replicative DNA damage and tolerance	20
The dynamics of chromatin architecture in brain development and function	19
The WRN helicase: resolving a new target in microsatellite unstable cancers	19
A lifelong duty: how Xist maintains the inactive X chromosome	19
Structural and functional brain alterations revealed by neuroimaging in CNV carriers	19
Replication stress: from chromatin to immunity and beyond	19
Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system	19
Homologous recombination deficiency: how genomic signatures are generated	18
Collective effects in epithelial cell death and cell extrusion	18
Evolution of 3D chromatin organization at different scales	18
Chromosomal instability as a source of genomic plasticity	18
All for one and one for all: heterogeneity of genetic etiologies in neurodevelopmental psychiatric disorders	18
Pigmentation and color pattern diversity in Odonata	17
Multi-scale dynamics of heterochromatin repair	17
Allele-specific expression: applications in cancer and technical considerations	16
Somatic variants in epilepsy – advancing gene discovery and disease mechanisms	16

Challenges of diagnostic genomics in Latin America	16
Recombination-mediated genome rearrangements	16
What crustaceans can tell us about the evolution of insect wings and other morphologically novel structures	16
What a finding of gene copy number variation can add to the diagnosis of developmental neuropsychiatric disorders	16
Reprogramming cellular identity during intestinal regeneration	16
The use of CRISPR/Cas9-based gene editing strategies to explore cancer gene function in mice	16
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer	15
Cellular and developmental basis of avian structural coloration	15
Histone isoforms and the oncohistone code	15
The X chromosome in C. elegans sex determination and dosage compensation	15
Molecular genetic mechanisms of congenital heart disease	15
Predicting immunotherapy response through genomics	15
7q11.23 deletion and duplication	15
Copy-number variation in congenital heart disease	15
The origins of cancer cell dormancy	15
Eco-evo-devo advances with butterfly eyespots	14
Brain organoids: the quest to decipher human-specific features of brain development	14
Stem-cell-based human and mouse embryo models	14
Cell cycle dynamics and developmental dynamics of the 3D genome: toward linking the two timescales	14
Seasonal plasticity: how do butterfly wing pattern traits evolve environmental responsiveness?	14
How strand exchange protein function benefits from ATP hydrolysis	14
Epithelial morphogenesis in organoids	13
Long overdue: including adults with brain disorders in precision health initiatives	13
Clinical evaluation of patients with a neuropsychiatric risk copy number variant	13
Kidney organoid research: current status and applications	13
The role of the intestinal microbiota in allogeneic HCT: clinical associations and preclinical mechanisms	12
Cell competition in vertebrates — a key machinery for tissue homeostasis	12
Reprogramming lineage identity through cell–cell fusion	12
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes	12
4D epigenomics: deciphering the coupling between genome folding and epigenomic regulation with biophysical modeling	12
Loop extrusion rules: the next generation	12
Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms	12
Crossover or non-crossover outcomes: tailored processing of homologous recombination intermediates	12
Copy number variants in neurexin genes: phenotypes and mechanisms	12
Contributions of 3D chromatin structure to cell-type-specific gene regulation	12
Use of mouse models to investigate the contributions of CNVs associated with schizophrenia and autism to disease mechanisms	12