Current Opinion in Genetics & Development

Article	Citations
Editorial Board	82
Editorial overview: Conflicts, conflicts everywhere	74
Editorial Board	59
Why is measuring and predicting fitness under genomic conflict so hard?	55
Adipose tissue endothelial cells: insights into their heterogeneity and functional diversity	53
Tile by tile: capturing the evolutionary mosaic of human conditions	51
A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation	42
Evolution and ecology of commensal gut protists: recent advances	40
R-loops in neurodegeneration	39
Integrative approaches to study enhancer–promoter communication	38
Convergence and divergence of molecular phenotypes in iPSC-derived models of 16p11.2 and 22q11.2 reciprocal copy number variants	36
Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation	34
Editorial Board	33
High-throughput approaches to functional characterization of genetic variation in yeast	31
Genetic clues to reprogramming power and formation of mouse oocyte	31
Exploring the origin of the development: totipotent stem cells	31
Control of cell fate upon transcription factor–driven cardiac reprogramming	30
In vitro models of pre- and post-gastrulation embryonic development	29
Toward the dissection of hematopoietic stem cell fates and their determinants	29
NAT10 and cytidine acetylation in mRNA: intersecting paths in development and disease	28
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate	27
Single-cell genomic profiling to study regeneration	27
Interplay between N-adenosine RNA methylation and mRNA splicing	27
Therapeutic strategies to target the epitranscriptomic machinery	27
Using human pluripotent stem cells to dissect trophoblast development	26

Cell–cell interactions between transplanted retinal organoid cells and recipient tissues	26
If you please, draw me a neuron — linking evolutionary tinkering with human neuron evolution	26
Recent advances in the neurogenomics of autism spectrum disorder	26
Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing	26
Long-term evolution of regulatory DNA sequences. Part 1: simulations on global, biophysically-realistic genotype–phenotype maps	26
Dynamic microenvironments shape nuclear organization and gene expression	26
Better together: how cooperativity influences transcriptional bursting	25
At the tip of regeneration	25
Genome instability in mammalian embryos implications for genome editing, development, and evolution	24
Behavioral evolution by diverging cell type composition	24
Editorial Board	24
Emerging oligo-based imaging methods to study chromatin organization in cells and tissue	24
Structural variation in humans and our primate kin in the era of telomere-to-telomere genomes and pangenomics	23
Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders	23
Progress toward complete cell-type and spatial-resolution atlases of the developing brain	21
Editorial overview: Drivers, droplets, and deeds of nuclear genome organization	20
Stem-cell-based human and mouse embryo models	20
Adipose tissue-derived lipokines in metabolism	20
Transposon waves at the water-to-land transition	20
Molecular genetics of pulmonary hypertension in children	20
Somatic variation in multiple sclerosis: from blood to brain	20
Human 8-cell embryo-like cells from pluripotent stem cells	19
Editorial Board	19
Nuclear remodeling during cell fate transitions	19
Enhancers on the edge — how the nuclear envelope controls gene regulatory elements	19
Modifying gastruloids to dissect mechanisms of tissue-specific induction	19
The Yin and Yang of replicative aging and rejuvenation	19
Chromosome organization by Structural Maintenance of Chromosomes complexes in C. elegans	19
Editorial overview: Multiscale regulation of genome folding in space, time, and across the tree of life	19
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium	19
Integrating multiomic layers to decode psychiatric disease mechanisms	18
The emergence of neurogenic lineage motifs in building the vertebrate retina	18
Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?	18
Mechanisms of lung regeneration and repair	18
Reassessing forebrain organization: recent evidence challenges the prosomere model	18
Linking phenotype to genotype using comprehensive genomic comparisons	18
Recipes and ingredients for deep learning models of 3D genome folding	18
Active processes shape and move the genome and nucleoplasm	18
A haystack in the needle: packaging sperm DNA in insects	18
Multi-organelle-mediated mRNA localization in neurons and links to disease	17
Shaping inheritance: how distinct reproductive strategies influence DNA methylation memory in plants	17
Evolution of 3D chromatin organization at different scales	17
Maternal genetic factors in the development of congenital heart defects	17
Meiotic drive of noncentromeric loci in mammalian meiosis II eggs	17
What are tethering elements?	17
Editorial Board	17
Epigenetic priming in the male germline	17
Biological roles of nonsense-mediated RNA decay: insights from the nervous system	17
Editorial overview: Peering into our history through a genetic lens: How advances in genetics are changing our understanding of human evolution	17
Editorial overview: Epigenetic inheritance: A shortcut to environmental adaptation?	17

Advances in skeletal genomics research across tissues and cells	17
Editorial overview: Epitranscriptomics: Exploring a new frontier in health and disease	16
Editorial Board	16
Approaches to probe and perturb long noncoding RNA functions in diseases	16
Cell identity conversion in liver regeneration after injury	16
Songbird germline-restricted chromosome as a potential arena of genetic conflicts	16
Rewiring cancer: 3D genome determinants of cancer hallmarks	16
Transposable elements in early human embryo development and embryo models	16
Inheritance of epigenetic transcriptional memory	16
Clonal analysis for understanding fate biases in developing embryos	16
Deciphering microglia phenotypes in health and disease	16
Editorial overview: Regaining architecture and cell cross-talk upon regeneration	15
Correlation between protein abundance and sequence conservation: what do recent experiments say?	15
Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations	15
Amending the injured heart by in vivo reprogramming	15
Decoding schizophrenia through postmortem human brain transcriptomics	15
Cellular plasticity in the neural crest and cancer	15
Editorial overview: The genome in space–time	14
Adipose tissue lipid metabolism: lipolysis	14
Cooperativity between regulatory elements acts as a modulator of enhancer function	14
Microbial experimental evolution in a massively multiplexed and high-throughput era	14
Principles of genome activation in the early embryo	14
Editorial overview: Evolutionary genetics (2025): mapping the molecular basis of phenotypic divergence	14
The stem cell zoo for comparative studies of developmental tempo	14
Evolutionary genetics meets ecological immunology: insights into the evolution of immune systems	14
Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation	14
Evolution and molecular bases of reproductive isolation	14
Recent developments in adipose tissue-secreted factors and their target organs	14
Long-term evolution of regulatory DNA sequences. Part 2: theory and future challenges	14
Toward a comprehensive view of gene architecture during transcription	14
A new era of understanding in vivo metabolic flux in thermogenic adipocytes	14
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes	14
Lineage tracing in gastruloids to understand determinants of early fate decisions	14
Brain organoids: the quest to decipher human-specific features of brain development	14
Exploring conditional gene essentiality through systems genetics approaches in yeast	13
RNA signaling in cellular plasticity during homeostasis and regeneration	13
Alternative splicing in addiction	13
Epistasis and evolutionary dependencies in human cancers	13
Deep learning for psychiatric genomics: from tools to applications	13
The role of loop extrusion in enhancer-mediated gene activation	13
In vitro models of human hypoblast and mouse primitive endoderm	13
Genome folding dynamics during the M-to-G1-phase transition	13
Bridging spatial and temporal scales of developmental gene regulation	13
Phase separation and inheritance of repressive chromatin domains	13
Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks	13
Editorial Board	13
When 3D genome changes cause disease: the impact of structural variations in congenital disease and cancer	12
Topical section: embryonic models (2023) for Current Opinion in Genetics & Development	12
Paternal genome elimination: patterns and mechanisms of drive and silencing	12
Reconstitution of reproductive organ system that produces functional oocytes	12
Editorial Overview: Developmental mechanisms patterning and evolution (2025)	12
Polycomb complexes in MLL–AF9-related leukemias	11
Prospects for precision genetic medicine in congenital heart disease	11
Pushing the experimental resolution boundary in chromatin fibre organisation using multiscale simulations	11
Editorial Board	11
Recent advances in stem cell-based blastocyst models	11
Editorial Board	11
Proliferation and dissemination of killer meiotic drive loci	11
Chromosome organization in 4D: insights from C. elegans development	11
Hijacked enhancer–promoter and silencer–promoter loops in cancer	10
Timing mechanisms: insights from comparative neural differentiation systems	10
Principles of long-range gene regulation	10
Can we stop one heart from breaking: triumphs and challenges in cardiac reprogramming	10
Spliceosome complex and neurodevelopmental disorders	10
Transposon persistence and control in germ cells	10
The metabolic baton: conducting the dance of N6-methyladenosine writing and erasing	10
R-loop homeostasis in genome dynamics, gene expression and development	10
Cellular diversity and developmental hierarchy in the planarian nervous system	10
Jack of all trades versus master of one: how generalist versus specialist strategies of transposable elements relate to their horizontal transfer between lineages	10
Progress in understanding the biological basis of polygenic disorders	10
The power of proximity: mechanisms and biological roles of transvection	10
Female meiotic drive in plants: mechanisms and dynamics	9
To splice or not to splice: pseudoexons in neurological disease and opportunities for intervention	9
The genetic landscape of cardiovascular left–right patterning defects	9
Unlocking regeneration: how partial reprogramming resembles tissue healing	9
Nonequilibrium polymer models for chromatin	9
Recent insights into the in vitro culture systems for mammalian embryos	9
Corneal regeneration: insights in epithelial stem cell heterogeneity and dynamics	9
Editorial Board	9
Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions	9

Editorial Board	9
Clinical Perspectives in Epitranscriptomics	9
Convergent re-evolution of CNS structures: focus on the fovea	9
Experimental evolution of drug resistance in human fungal pathogens	9
Modification of the RNA methylome in neurodevelopmental disorders	9
Mitochondrial curation for the next generation	9
Immune dysfunction in psychiatric disorders: emerging genomic insights	9
ETV2 for endothelial fate specification	9
Quantitative mapping of the mammalian epitranscriptome	9
Ex situ-armus: experimental models for combating respiratory dysfunction	9
The role of cohesin and DNA loop extrusion in the generation of single neuron identity	9
Epigenetic dynamics during germline development: insights from Drosophila and C. elegans	9
Pediatric CNS cancer genomics and immunogenomics	9
Temporal patterning of the vertebrate developing neural tube	9
Insights into multilevel spatial regulation within the root stem cell niche	8
Block copolymer concepts of how transcription organizes the stem cell genome	8
The ever-growing world of gastruloids: autogenous models of mammalian embryogenesis	8
Vascular and immune interactions in islets transplantation and 3D islet models	8
Mechanisms of regulatory evolution in yeast	8
Interplay of transposable elements and ageing: epigenetic regulation and potential epitranscriptomic influence	8
The ribonucleoprotein network of the nucleus: a historical perspective	8
Overcoming muscle stem cell aging	8
Circuit integration by transplanted human neurons	8
Transgenerational epigenetic control of constitutive heterochromatin, transposons, and centromeres	8
Finding the genetic basis of adaptation: reducing complexity to improve trait mapping	8
Recent insights into the evolution of mutation rates in yeast	8
Pluripotent stem cell–derived mesenchymal stem cells for therapeutic applications, developmental study, and cancer research	8
Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity	8
Epistatic drift in protein evolution	8
Linking mitochondria metabolism, developmental timing, and human brain evolution	8
Network models of chromatin structure	8
Genetic risk modeling approaches to resolve phenotypic and molecular heterogeneity in psychiatric disorders	8
Do sex-linked male meiotic drivers contribute to intrinsic hybrid incompatibilities? Recent empirical studies from flies and rodents	8
Evolutionary neurogenomics at single-cell resolution	8
Xenotransplantation — a shortcut to construct tissue complexity in organoids	8
NOVA1/2 genes and alternative splicing in neurodevelopment	8
Narrative engineering of the liver	7
Engineering immune organoids to regenerate host immune system	7
Deciphering the role of structural variation in human evolution: a functional perspective	7
A new era in neuromuscular junction research: current advances in self-organized and assembled in vitro models	7
Editorial overview: Early embryonic development models: back to the beginning	7
Advancements in inner ear development, regeneration, and repair through otic organoids	7
New methodological approaches and insights gained toward understanding the evolved human skeleton	7
Therapeutic index of targeting select chromatin complexes in human cancer patients	7
Concepts, mechanisms and implications of long-term epigenetic inheritance	7
A lifelong duty: how Xist maintains the inactive X chromosome	7
Plasticity of muscle stem cells in homeostasis and aging	7
Factors that determine cell type–specific CTCF binding in health and disease	7
Extending the spectrum in aortopathy: stenosis to aneurysm	7
Early central nervous system development and neuron regeneration	7
When and why are mitochondria paternally inherited?	7
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation	7
Adipocyte plasticity in tissue regeneration, repair, and disease	7
Editorial overview: Fat tissue in focus: Assembled deeply insightful perspectives on state-of-the-art explorations	6
Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation	6
Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe	6
Evolutionary specializations in primate cortical development	6
Editorial Board	6
Human trophoblast stem cell-state acquisition from pluripotent stem cells and somatic cells	6
Decoding the role of tRNA modifications in cancer progression	6
Rethinking chromatin accessibility: from compaction to dynamic interactions	6
Editorial overview: New insights into epithelial dynamics: From tissue homeostasis to morphogenesis	6
Molecular mechanisms of the specialization of human synapses in the neocortex	6
Revitalizing psychopharmacology in the GWAS era: the potential of barcoded screening in drug discovery	6
Safeguarding the epigenome through the cell cycle: a multitasking game	6