Current Opinion in Genetics & Development

Article	Citations
Enhancer-promoter communication: hubs or loops?	109
To loop or not to loop: what is the role of TADs in enhancer function and gene regulation?	66
Spatially resolved transcriptomics and its applications in cancer	64
Role of VPS13, a protein with similarity to ATG2, in physiology and disease	56
Evolution of sexual development and sexual dimorphism in insects	55
Copy number variation and neuropsychiatric illness	52
16p11.2 deletion syndrome	51
Diverse lncRNA mechanisms in brain development and disease	49
Single-molecule tracking of transcription protein dynamics in living cells: seeing is believing, but what are we seeing?	48
Advances in colon cancer research: in vitro and animal models	44
Regulation of 3D chromatin organization by CTCF	43
Evolution of pigment cells and patterns: recent insights from teleost fishes	40
Nuclear mechanisms of gene expression control: pre-mRNA splicing as a life or death decision	39
Microexons: at the nexus of nervous system development, behaviour and autism spectrum disorder	39
The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases	38
4D nucleome modeling	37
Structure-forming repeats and their impact on genome stability	37
The evolution of the human brain and disease susceptibility	35
Poison exons in neurodevelopment and disease	35
Microglial ontogeny, diversity and neurodevelopmental functions	35
Advances in repeat expansion diseases and a new concept of repeat motif–phenotype correlation	34
The evolution of structural colour in butterflies	34
Active nematics across scales from cytoskeleton organization to tissue morphogenesis	33
DNA end resection during homologous recombination	32
Diagnostic genetic testing for neurodevelopmental psychiatric disorders: closing the gap between recommendation and clinical implementation	32

The shifting shape of genomes: dynamics of heterochromatin interactions at the nuclear lamina	31
New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders	31
Extrachromosomal DNA (ecDNA) in cancer pathogenesis	31
The nuclear pore complex and the genome: organizing and regulatory principles	30
Break-induced replication mechanisms in yeast and mammals	30
An extending ATR–CHK1 circuitry: the replication stress response and beyond	29
The transcription factor code in iPSC reprogramming	28
Activity regulates brain development in the fly	28
The evolution of post-translational modifications	27
The stochastic nature of genome organization and function	26
Exosomes in cancer development	26
Disentangling the paradox of the PCDH19 clustering epilepsy, a disorder of cellular mosaics	26
Genetic pathways involved in human speech disorders	25
LINC complex regulation of genome organization and function	24
Cortico-basal ganglia circuits underlying dysfunctional control of motor behaviors in neuropsychiatric disorders	24
Mechanisms of maternal intergenerational epigenetic inheritance	24
The role of SAF-A/hnRNP U in regulating chromatin structure	23
Digesting the mechanobiology of the intestinal epithelium	23
The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization	23
Insights into clonal hematopoiesis and its relation to cancer risk	23
Evo-devo of shell colour in gastropods and bivalves	22
H3–H4 histone chaperones and cancer	22
Mitotic recombination in yeast: what we know and what we don’t know	22
How gene duplication diversifies the landscape of protein oligomeric state and function	22
The role of somatic mosaicism in brain disease	22
The role of loop extrusion in enhancer-mediated gene activation	22
Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function	21
Distinct fibroblasts in scars and regeneration	21
Serine ADP-ribosylation in DNA-damage response regulation	21
The dawn of non-human primate models for neurodevelopmental disorders	21
Molecular mechanisms for targeted ASD treatments	21
Noncanonical imprinting: intergenerational epigenetic inheritance mediated by Polycomb complexes	21
Recombination and restart at blocked replication forks	20
Homologous recombination within repetitive DNA	20
RAD51 paralog function in replicative DNA damage and tolerance	20
The dynamics of chromatin architecture in brain development and function	19
The WRN helicase: resolving a new target in microsatellite unstable cancers	19
A lifelong duty: how Xist maintains the inactive X chromosome	19
Structural and functional brain alterations revealed by neuroimaging in CNV carriers	19
Replication stress: from chromatin to immunity and beyond	19
Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system	19
Evolution of 3D chromatin organization at different scales	18
Chromosomal instability as a source of genomic plasticity	18
All for one and one for all: heterogeneity of genetic etiologies in neurodevelopmental psychiatric disorders	18
Homologous recombination deficiency: how genomic signatures are generated	18
Collective effects in epithelial cell death and cell extrusion	18
Pigmentation and color pattern diversity in Odonata	17
Multi-scale dynamics of heterochromatin repair	17
Challenges of diagnostic genomics in Latin America	16
Recombination-mediated genome rearrangements	16

What crustaceans can tell us about the evolution of insect wings and other morphologically novel structures	16
What a finding of gene copy number variation can add to the diagnosis of developmental neuropsychiatric disorders	16
Reprogramming cellular identity during intestinal regeneration	16
The use of CRISPR/Cas9-based gene editing strategies to explore cancer gene function in mice	16
Allele-specific expression: applications in cancer and technical considerations	16
Somatic variants in epilepsy – advancing gene discovery and disease mechanisms	16
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer	15
Cellular and developmental basis of avian structural coloration	15
The X chromosome in C. elegans sex determination and dosage compensation	15
Copy-number variation in congenital heart disease	15
Molecular genetic mechanisms of congenital heart disease	15
Predicting immunotherapy response through genomics	15
Histone isoforms and the oncohistone code	15
7q11.23 deletion and duplication	15
The origins of cancer cell dormancy	15
Seasonal plasticity: how do butterfly wing pattern traits evolve environmental responsiveness?	14
How strand exchange protein function benefits from ATP hydrolysis	14
Eco-evo-devo advances with butterfly eyespots	14
Brain organoids: the quest to decipher human-specific features of brain development	14
Stem-cell-based human and mouse embryo models	14
Cell cycle dynamics and developmental dynamics of the 3D genome: toward linking the two timescales	14
Kidney organoid research: current status and applications	13
Epithelial morphogenesis in organoids	13
Long overdue: including adults with brain disorders in precision health initiatives	13
Clinical evaluation of patients with a neuropsychiatric risk copy number variant	13
Crossover or non-crossover outcomes: tailored processing of homologous recombination intermediates	12
Copy number variants in neurexin genes: phenotypes and mechanisms	12
Contributions of 3D chromatin structure to cell-type-specific gene regulation	12
Use of mouse models to investigate the contributions of CNVs associated with schizophrenia and autism to disease mechanisms	12
The role of the intestinal microbiota in allogeneic HCT: clinical associations and preclinical mechanisms	12
Cell competition in vertebrates — a key machinery for tissue homeostasis	12
Reprogramming lineage identity through cell–cell fusion	12
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes	12
4D epigenomics: deciphering the coupling between genome folding and epigenomic regulation with biophysical modeling	12
Loop extrusion rules: the next generation	12
Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms	12
Shaping inheritance: how distinct reproductive strategies influence DNA methylation memory in plants	11
Relationship between epithelial organization and morphogen interpretation	11
The evolutionary and ecological potential of yeast hybrids	11
Microbial experimental evolution in a massively multiplexed and high-throughput era	11
Regional patterning and regulation of melanin pigmentation in insects	11
Reconsidering pathway choice: a sequential model of mammalian DNA double-strand break pathway decisions	11
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium	11
Recombination-dependent replication: new perspectives from site-specific fork barriers	11
Dysregulated translational control in brain disorders: from genes to behavior	11
Cancer-associated chromatin variants uncover the oncogenic role of transposable elements	11
Regulatory principles and mechanisms governing the onset of random X-chromosome inactivation	11
Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?	11
Lessons from single cell sequencing in CNS cell specification and function	11
Epigenetic dynamics during germline development: insights from Drosophila and C. elegans	11
Metabolic regulation in pluripotent stem cells	10
Insights into the control of RAD51 nucleoprotein filament dynamics from single-molecule studies	10
Communication between chromatin and homologous recombination	10
A GC-centered view of 3D genome organization	10
Evolution of short linear motifs and disordered proteins Topic: yeast as model system to study evolution	10
Building the genome architecture during the maternal to zygotic transition	10
Advancements in inner ear development, regeneration, and repair through otic organoids	10
Heliconius butterflies: a window into the evolution and development of diversity	10
Architecture of RNA–RNA interactions	10
DNA helicases in homologous recombination repair	10
When and why are mitochondria paternally inherited?	10
Metabolic regulation of cardiac regeneration: roles of hypoxia, energy homeostasis, and mitochondrial dynamics	10
May the best wound WIHN: the hallmarks of wound-induced hair neogenesis	10
Epigenetic memory in reprogramming	10
A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila	10
Evo-devo of wing colour patterns in beetles	9
The genetic landscape of cardiovascular left–right patterning defects	9
In search of conserved principles of planar cell polarization	9
Non-model systems in mammalian forelimb evo-devo	9
Cell plasticity in regeneration in the stomach and beyond	9
Adipocyte plasticity in tissue regeneration, repair, and disease	9
Understanding lncRNA–protein assemblies with imaging and single-molecule approaches	9
Cell type innovation at the tips of the animal tree	9
Discrete roles for Rad54 and Rdh54 during homologous recombination	9
Biochemical properties of fission yeast homologous recombination enzymes	9
The evolution and genetics of lepidopteran egg and caterpillar coloration	9
Network models of chromatin structure	9
Recent progress and challenges in single-cell imaging of enhancer–promoter interaction	8
Evolution and molecular bases of reproductive isolation	8
Corneal regeneration: insights in epithelial stem cell heterogeneity and dynamics	8

Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming	8
Epithelial–immune crosstalk in health and disease	8
Gene constraint and genotype–phenotype correlations in neurodevelopmental disorders	8
It’s all in the combination: decoding the epigenome for cancer research and diagnostics	8
Centromere drive: chromatin conflict in meiosis	8
Cancer epitranscriptomics in a nutshell	8
Trends and variation in vertebrate patterns as outcomes of self-organization	8
Recent developments in adipose tissue-secreted factors and their target organs	8
Replication timing and transcriptional control: beyond cause and effect — part IV	8
Correlation between protein abundance and sequence conservation: what do recent experiments say?	8
Making region-specific integumentary organs in birds: evolution and modifications	8
Something old, something new, something borrowed, something red: the origin of ecologically relevant novelties in Hemiptera	7
The role of tissue maturity and mechanical state in controlling cell extrusion	7
Somatic copy number variants in neuropsychiatric disorders	7
Nucleic acid therapeutics in neurodevelopmental disease	7
Cellular diversity and developmental hierarchy in the planarian nervous system	7
Recent insights into the evolution of mutation rates in yeast	7
Redox-mediated regulation of low complexity domain self-association	7
Insights into homology search from cryo-EM structures of RecA-DNA recombination intermediates	7
Regulatory landscape in brain development and disease	7
Exploring conditional gene essentiality through systems genetics approaches in yeast	7
Horizontal gene transfer in yeasts	7
Evolutionary dynamics between transposable elements and their host genomes: mechanisms of suppression and escape	7
The frontiers of sequencing in undiagnosed neurodevelopmental diseases	7
Songbird germline-restricted chromosome as a potential arena of genetic conflicts	7
Chromatin architecture reorganization during somatic cell reprogramming	6
A finger on the pulse of regeneration: insights into the cellular mechanisms of adult digit tip regeneration	6
Exploring new roles for RNA-binding proteins in epigenetic and gene regulation	6
When 3D genome changes cause disease: the impact of structural variations in congenital disease and cancer	6
Advances in SUMO-based regulation of homologous recombination	6
The ribonucleoprotein network of the nucleus: a historical perspective	6
In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?	6
Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture	6
Paternal genome elimination: patterns and mechanisms of drive and silencing	6
Epistasis and evolutionary dependencies in human cancers	6
Pathways to understanding psychosis through rare – 22q11.2DS - and common variants	6
Diversification of the vertebrate limb: sequencing the events	6
Functional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease	6
Cancer regulatory variation	6
Mitonuclear interplay in yeast: from speciation to phenotypic adaptation	6
Human thermogenic adipose tissue	6
Advancing global equity in cancer genomics – challenges and opportunities in Sub-Saharan Africa	6
Mechanisms of regulatory evolution in yeast	6
Control of structure-specific endonucleases during homologous recombination in eukaryotes	6
Genetics of congenital arrhythmia syndromes: the challenge of variant interpretation	5
Human 8-cell embryo-like cells from pluripotent stem cells	5
Concepts, mechanisms and implications of long-term epigenetic inheritance	5
Going wild: ecology and genomics are crucial to understand yeast evolution	5
Adipose tissue lipid metabolism: lipolysis	5
A CTCF-dependent mechanism underlies the Hox timer: relation to a segmented body plan	5
Plasticity of muscle stem cells in homeostasis and aging	5
Chromosome organization in 4D: insights from C. elegans development	5
Proliferation and dissemination of killer meiotic drive loci	5
Genome folding dynamics during the M-to-G1-phase transition	5
Recent progress in understanding the genomic architecture of sexual conflict	5
RNA interference therapeutics for cardiac regeneration	5
Regulation of mammalian totipotency: a molecular perspective from in vivo and in vitro studies	5
Editorial overview: Rare CNV disorders and neuropsychiatric phenotypes: opportunities, challenges, solutions	5
Towards a CRISPeR understanding of homologous recombination with high-throughput functional genomics	5
Modeling X-chromosome inactivation and reactivation during human development	5
Long interspersed nuclear element 1 and B1/Alu repeats blueprint genome compartmentalization	4
Mechanism of mitotic recombination: insights from C. elegans	4
Dynamic microenvironments shape nuclear organization and gene expression	4
Exploring the role of ribosomal RNA modifications in cancer	4
Epithelial dynamics during early mouse development	4
Dissecting the complexity of CNV pathogenicity: insights from Drosophila and zebrafish models	4
Repurposing developmental mechanisms in the adult nervous system	4
Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation	4
Extending the spectrum in aortopathy: stenosis to aneurysm	4
5D superresolution imaging for a live cell nucleus	4
New perspectives on the causes and consequences of male meiotic drive	4
Exploring the heterogeneity of white adipose tissue in mouse and man	4
Epithelial folding determines the final shape of beetle horns	4
Experimental evolution of drug resistance in human fungal pathogens	4
Interplay between Sae2 and Rif2 in the regulation of Mre11-Rad50 activities at DNA ends	4
Spinal cord regeneration — the origins of progenitor cells for functional rebuilding	4
Evolutionary codependency: insights into the mitonuclear interaction landscape from experimental and wild Caenorhabditis nematodes	4
Molecular genetics of pulmonary hypertension in children	4
Evaluating the role of sexual antagonism in the evolution of sex chromosomes: new data from fish	4
3D chromosomal architecture in germinal center B cells and its alterations in lymphomagenesis	4
Finding needles in a haystack: dissecting tumor heterogeneity with single-cell transcriptomic and chromatin accessibility profiling	4
Transposable elements in early human embryo development and embryo models	4
Deciphering microglia phenotypes in health and disease	4