Current Opinion in Genetics & Development

Article	Citations
Enhancer-promoter communication: hubs or loops?	82
The role of 3D chromatin domains in gene regulation: a multi-facetted view on genome organization	64
Spatially resolved transcriptomics and its applications in cancer	59
Role of VPS13, a protein with similarity to ATG2, in physiology and disease	47
Chromosome dynamics during interphase: a biophysical perspective	46
To loop or not to loop: what is the role of TADs in enhancer function and gene regulation?	44
Evolution of sexual development and sexual dimorphism in insects	43
Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture	43
CTCF and CTCFL in cancer	43
The many faces of Polycomb regulation by RNA	42
Evolution of the mutation rate across primates	41
Diverse lncRNA mechanisms in brain development and disease	41
16p11.2 deletion syndrome	39
Regulation of 3D chromatin organization by CTCF	38
Copy number variation and neuropsychiatric illness	37
Single-molecule tracking of transcription protein dynamics in living cells: seeing is believing, but what are we seeing?	37
Advances in colon cancer research: in vitro and animal models	34
Microexons: at the nexus of nervous system development, behaviour and autism spectrum disorder	34
4D nucleome modeling	34
Structure-forming repeats and their impact on genome stability	33
Evolution of pigment cells and patterns: recent insights from teleost fishes	32
Microglial ontogeny, diversity and neurodevelopmental functions	30
Epigenetic regulation of mouse preimplantation embryo development	30
Advances in repeat expansion diseases and a new concept of repeat motif–phenotype correlation	30
The evolution of the human brain and disease susceptibility	29

African population history: an ancient DNA perspective	29
The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases	28
Nuclear mechanisms of gene expression control: pre-mRNA splicing as a life or death decision	28
Diagnostic genetic testing for neurodevelopmental psychiatric disorders: closing the gap between recommendation and clinical implementation	28
Mesoscale organization of the chromatin fiber	27
New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders	27
The self-stirred genome: large-scale chromatin dynamics, its biophysical origins and implications	27
Generations of genomes: advances in paleogenomics technology and engagement for Indigenous people of the Americas	26
Extrachromosomal DNA (ecDNA) in cancer pathogenesis	26
A cell in hand is worth two in the embryo: recent advances in 2-cell like cell reprogramming	26
An extending ATR–CHK1 circuitry: the replication stress response and beyond	25
The evolution of structural colour in butterflies	25
Rising from the ashes: cellular senescence in regeneration	25
Break-induced replication mechanisms in yeast and mammals	25
Exosomes in cancer development	24
The shifting shape of genomes: dynamics of heterochromatin interactions at the nuclear lamina	24
Poison exons in neurodevelopment and disease	24
Biophysical mechanisms of chromatin patterning	23
Experimental embryology of gastrulation: pluripotent stem cells as a new model system	23
Activity regulates brain development in the fly	23
Cortico-basal ganglia circuits underlying dysfunctional control of motor behaviors in neuropsychiatric disorders	23
The nuclear pore complex and the genome: organizing and regulatory principles	23
The transcription factor code in iPSC reprogramming	22
Inferring evolutionary dynamics of mutation rates through the lens of mutation spectrum variation	22
The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization	21
Mechanisms of maternal intergenerational epigenetic inheritance	21
LINC complex regulation of genome organization and function	21
Disentangling the paradox of the PCDH19 clustering epilepsy, a disorder of cellular mosaics	21
The role of somatic mosaicism in brain disease	20
Insights into clonal hematopoiesis and its relation to cancer risk	20
Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks	20
Differential 3D chromatin organization and gene activity in genomic imprinting	20
DNA end resection during homologous recombination	19
Replication stress: from chromatin to immunity and beyond	19
Control of cell shape during epithelial morphogenesis: recent advances	19
Genetic pathways involved in human speech disorders	19
Mitotic recombination in yeast: what we know and what we don’t know	19
Human adaptation over the past 40,000 years	19
Serine ADP-ribosylation in DNA-damage response regulation	19
The evolution of post-translational modifications	18
Active nematics across scales from cytoskeleton organization to tissue morphogenesis	18
Molecular mechanisms for targeted ASD treatments	18
Update on Müller glia regenerative potential for retinal repair	18
Prime time for primate functional genomics	18
Digesting the mechanobiology of the intestinal epithelium	18
Xeno-organ donor pigs with multiple genetic modifications – the more the better?	18
The dawn of non-human primate models for neurodevelopmental disorders	18
Stabilizing hematopoietic stem cells in vitro	17
RAD51 paralog function in replicative DNA damage and tolerance	17
H3–H4 histone chaperones and cancer	17

The dynamics of chromatin architecture in brain development and function	17
Human evolutionary history in Eastern Eurasia using insights from ancient DNA	17
Evo-devo of shell colour in gastropods and bivalves	17
Engineering and modeling of multicellular morphologies and patterns	17
Distinct fibroblasts in scars and regeneration	17
Recent insights into zebrafish cardiac regeneration	16
Recombination and restart at blocked replication forks	16
Latest trends in archaeogenetic research of west Eurasians	16
The use of CRISPR/Cas9-based gene editing strategies to explore cancer gene function in mice	16
Linking genotype, cell behavior, and phenotype: multidisciplinary perspectives with a basis in zebrafish patterns	16
Collective effects in epithelial cell death and cell extrusion	16
Homologous recombination within repetitive DNA	16
The role of SAF-A/hnRNP U in regulating chromatin structure	16
The stochastic nature of genome organization and function	16
Pigmentation and color pattern diversity in Odonata	15
What a finding of gene copy number variation can add to the diagnosis of developmental neuropsychiatric disorders	15
Somatic variants in epilepsy – advancing gene discovery and disease mechanisms	15
Regeneration in the spiny mouse, Acomys, a new mammalian model	15
Cellular and developmental basis of avian structural coloration	15
Mechanical induction and competence in epithelial morphogenesis	15
How gene duplication diversifies the landscape of protein oligomeric state and function	15
Structural and functional brain alterations revealed by neuroimaging in CNV carriers	14
Multi-scale dynamics of heterochromatin repair	14
Gene regulation by non-coding RNAs in the 3D genome architecture	14
ERK signaling dynamics in the morphogenesis and homeostasis of Drosophila	14
Single cell analysis pushes the boundaries of TAD formation and function	14
Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system	14
The X chromosome in C. elegans sex determination and dosage compensation	14
Histone isoforms and the oncohistone code	14
All for one and one for all: heterogeneity of genetic etiologies in neurodevelopmental psychiatric disorders	13
Chromosomal instability as a source of genomic plasticity	13
The role of loop extrusion in enhancer-mediated gene activation	13
The WRN helicase: resolving a new target in microsatellite unstable cancers	13
Homologous recombination deficiency: how genomic signatures are generated	13
Noncanonical imprinting: intergenerational epigenetic inheritance mediated by Polycomb complexes	13
7q11.23 deletion and duplication	13
Seasonal plasticity: how do butterfly wing pattern traits evolve environmental responsiveness?	12
Challenges of diagnostic genomics in Latin America	12
Lighting up single-mRNA translation dynamics in living cells	12
What crustaceans can tell us about the evolution of insect wings and other morphologically novel structures	12
Vertebrate brain regeneration – a community effort of fate-restricted precursor cell types	12
Reprogramming cellular identity during intestinal regeneration	12
Clinical evaluation of patients with a neuropsychiatric risk copy number variant	12
Eco-evo-devo advances with butterfly eyespots	12
Cell competition in vertebrates — a key machinery for tissue homeostasis	12
Allele-specific expression: applications in cancer and technical considerations	12
The role of the intestinal microbiota in allogeneic HCT: clinical associations and preclinical mechanisms	11
Lessons from single cell sequencing in CNS cell specification and function	11
Dysregulated translational control in brain disorders: from genes to behavior	11
The origins of cancer cell dormancy	11
Stem-cell-based human and mouse embryo models	11
Recombination-mediated genome rearrangements	11
The history behind the mosaic of the Americas	11
Long overdue: including adults with brain disorders in precision health initiatives	11
How strand exchange protein function benefits from ATP hydrolysis	11
Use of mouse models to investigate the contributions of CNVs associated with schizophrenia and autism to disease mechanisms	11
Predicting immunotherapy response through genomics	11
Crossover or non-crossover outcomes: tailored processing of homologous recombination intermediates	10
Evolution of 3D chromatin organization at different scales	10
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer	10
Brain organoids: the quest to decipher human-specific features of brain development	10
A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila	10
Reconsidering pathway choice: a sequential model of mammalian DNA double-strand break pathway decisions	10
Plants are better engineers: the complexity of plant organ morphogenesis	10
Molecular genetic mechanisms of congenital heart disease	10
From biomechanics to mechanobiology: Xenopus provides direct access to the physical principles that shape the embryo	10
Broadening primate genomics: new insights into the ecology and evolution of primate gene regulation	10
Copy number variants in neurexin genes: phenotypes and mechanisms	10
Kidney organoid research: current status and applications	10
Epithelial morphogenesis in organoids	10
Relationship between epithelial organization and morphogen interpretation	9
Microbial experimental evolution in a massively multiplexed and high-throughput era	9
Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function	9
A lifelong duty: how Xist maintains the inactive X chromosome	9
May the best wound WIHN: the hallmarks of wound-induced hair neogenesis	9
Neural circuit reorganisation after spinal cord injury in zebrafish	9
4D epigenomics: deciphering the coupling between genome folding and epigenomic regulation with biophysical modeling	9
Synthetic human embryology: towards a quantitative future	9
Cell type innovation at the tips of the animal tree	8
Regional patterning and regulation of melanin pigmentation in insects	8

Mechanobiology of vertebrate gut morphogenesis	8
Discrete roles for Rad54 and Rdh54 during homologous recombination	8
Building the genome architecture during the maternal to zygotic transition	8
Heliconius butterflies: a window into the evolution and development of diversity	8
Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms	8
DNA helicases in homologous recombination repair	8
Adaptive viscoelasticity of epithelial cell junctions: from models to methods	8
Insights into the control of RAD51 nucleoprotein filament dynamics from single-molecule studies	8
Branching out: what omics can tell us about primate evolution	8
Cell cycle dynamics and developmental dynamics of the 3D genome: toward linking the two timescales	8
Archaic hominin genomics provides a window into gene expression evolution	8
Cancer-associated chromatin variants uncover the oncogenic role of transposable elements	8
Advancements in inner ear development, regeneration, and repair through otic organoids	8
Non-model systems in mammalian forelimb evo-devo	7
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes	7
Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?	7
Contributions of 3D chromatin structure to cell-type-specific gene regulation	7
Metabolic regulation in pluripotent stem cells	7
Epithelial–immune crosstalk in health and disease	7
Reprogramming lineage identity through cell–cell fusion	7
Evo-devo of wing colour patterns in beetles	7
Redox-mediated regulation of low complexity domain self-association	7
Evolution of short linear motifs and disordered proteins Topic: yeast as model system to study evolution	7
The genetic landscape of cardiovascular left–right patterning defects	6
Something old, something new, something borrowed, something red: the origin of ecologically relevant novelties in Hemiptera	6
Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis	6
Communication between chromatin and homologous recombination	6
Insights into homology search from cryo-EM structures of RecA-DNA recombination intermediates	6
The frontiers of sequencing in undiagnosed neurodevelopmental diseases	6
Trends and variation in vertebrate patterns as outcomes of self-organization	6
Regulatory landscape in brain development and disease	6
Nucleic acid therapeutics in neurodevelopmental disease	6
Cancer regulatory variation	6
The role of tissue maturity and mechanical state in controlling cell extrusion	6
Understanding lncRNA–protein assemblies with imaging and single-molecule approaches	6
Metabolic regulation of cardiac regeneration: roles of hypoxia, energy homeostasis, and mitochondrial dynamics	6
Recent developments in adipose tissue-secreted factors and their target organs	6
Epigenetic dynamics during germline development: insights from Drosophila and C. elegans	6
Somatic copy number variants in neuropsychiatric disorders	6
Functional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease	6
Single cell genomics and developmental biology: moving beyond the generation of cell type catalogues	6
Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture	6
In search of conserved principles of planar cell polarization	6
Recombination-dependent replication: new perspectives from site-specific fork barriers	6
Recent insights into the evolution of mutation rates in yeast	6
Evolution and molecular bases of reproductive isolation	6
Architecture of RNA–RNA interactions	6
Methods for detecting introgressed archaic sequences	6
In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?	6
Making region-specific integumentary organs in birds: evolution and modifications	6
Biochemical properties of fission yeast homologous recombination enzymes	6
RNA interference therapeutics for cardiac regeneration	5
A finger on the pulse of regeneration: insights into the cellular mechanisms of adult digit tip regeneration	5
The evolutionary and ecological potential of yeast hybrids	5
Advancing global equity in cancer genomics – challenges and opportunities in Sub-Saharan Africa	5
Centromere drive: chromatin conflict in meiosis	5
A GC-centered view of 3D genome organization	5
The importance of including ethnically diverse populations in studies of quantitative trait evolution	5
Harnessing epigenetics to study human evolution	5
Towards a CRISPeR understanding of homologous recombination with high-throughput functional genomics	5
Copy-number variation in congenital heart disease	5
It’s all in the combination: decoding the epigenome for cancer research and diagnostics	5
Replication timing and transcriptional control: beyond cause and effect — part IV	5
Control of structure-specific endonucleases during homologous recombination in eukaryotes	5
Chromatin architecture reorganization during somatic cell reprogramming	5
Shaping inheritance: how distinct reproductive strategies influence DNA methylation memory in plants	5
Adipocyte plasticity in tissue regeneration, repair, and disease	5
Gene constraint and genotype–phenotype correlations in neurodevelopmental disorders	5
Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming	5
Epigenetic memory in reprogramming	5
Cancer epitranscriptomics in a nutshell	5