Current Opinion in Genetics & Development

Article	Citations
Editorial Board	54
Adipose tissue endothelial cells: insights into their heterogeneity and functional diversity	53
Integrative approaches to study enhancer–promoter communication	53
Editorial overview: Conflicts, conflicts everywhere	47
Editorial Board	44
Editorial Board	44
Why is measuring and predicting fitness under genomic conflict so hard?	43
The X chromosome in C. elegans sex determination and dosage compensation	41
Break-induced replication mechanisms in yeast and mammals	41
Epithelial–immune crosstalk in health and disease	39
A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation	36
Evolution and ecology of commensal gut protists: recent advances	36
Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation	35
Tile by tile: capturing the evolutionary mosaic of human conditions	33
DNA end resection during homologous recombination	32
R-loops in neurodegeneration	31
Editorial Board	30
Interplay between N-adenosine RNA methylation and mRNA splicing	29
Control of cell fate upon transcription factor–driven cardiac reprogramming	28
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate	28
Therapeutic strategies to target the epitranscriptomic machinery	28
Cell–cell interactions between transplanted retinal organoid cells and recipient tissues	27
High-throughput approaches to functional characterization of genetic variation in yeast	27
Genetic clues to reprogramming power and formation of mouse oocyte	27
NAT10 and cytidine acetylation in mRNA: intersecting paths in development and disease	27

Toward the dissection of hematopoietic stem cell fates and their determinants	27
Exploring the origin of the development: totipotent stem cells	27
In vitro models of pre- and post-gastrulation embryonic development	27
If you please, draw me a neuron — linking evolutionary tinkering with human neuron evolution	26
Using human pluripotent stem cells to dissect trophoblast development	25
Recombination-mediated genome rearrangements	25
Genome instability in mammalian embryos implications for genome editing, development, and evolution	25
Single-cell genomic profiling to study regeneration	25
Structural variation in humans and our primate kin in the era of telomere-to-telomere genomes and pangenomics	24
Better together: how cooperativity influences transcriptional bursting	24
Transposon waves at the water-to-land transition	23
Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing	23
Molecular genetics of pulmonary hypertension in children	23
Adipose tissue-derived lipokines in metabolism	22
Dynamic microenvironments shape nuclear organization and gene expression	22
How strand exchange protein function benefits from ATP hydrolysis	22
Stem-cell-based human and mouse embryo models	21
Editorial overview: Drivers, droplets, and deeds of nuclear genome organization	21
Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders	21
A haystack in the needle: packaging sperm DNA in insects	20
The Yin and Yang of replicative aging and rejuvenation	20
Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?	19
Nuclear remodeling during cell fate transitions	19
Editorial overview: Multiscale regulation of genome folding in space, time, and across the tree of life	19
Enhancers on the edge — how the nuclear envelope controls gene regulatory elements	19
Linking phenotype to genotype using comprehensive genomic comparisons	19
Modifying gastruloids to dissect mechanisms of tissue-specific induction	19
Recipes and ingredients for deep learning models of 3D genome folding	19
Digesting the mechanobiology of the intestinal epithelium	18
Editorial overview: Recombination — the ends justify the means	18
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium	18
Human 8-cell embryo-like cells from pluripotent stem cells	18
Multi-organelle-mediated mRNA localization in neurons and links to disease	17
Editorial overview: Peering into our history through a genetic lens: How advances in genetics are changing our understanding of human evolution	17
Shaping inheritance: how distinct reproductive strategies influence DNA methylation memory in plants	17
Biological roles of nonsense-mediated RNA decay: insights from the nervous system	16
Advances in skeletal genomics research across tissues and cells	16
Epigenetic priming in the male germline	16
Transposable elements in early human embryo development and embryo models	16
Editorial Board	16
Evolution of 3D chromatin organization at different scales	16
Rewiring cancer: 3D genome determinants of cancer hallmarks	16
Meiotic drive of noncentromeric loci in mammalian meiosis II eggs	16
What are tethering elements?	16
Cancer-associated chromatin variants uncover the oncogenic role of transposable elements	15
Maternal genetic factors in the development of congenital heart defects	15
Inheritance of epigenetic transcriptional memory	15
DNA helicases in homologous recombination repair	15
Editorial overview: Epigenetic inheritance: A shortcut to environmental adaptation?	15
Deciphering microglia phenotypes in health and disease	15

Cell identity conversion in liver regeneration after injury	15
Approaches to probe and perturb long noncoding RNA functions in diseases	14
Editorial overview: Epitranscriptomics: Exploring a new frontier in health and disease	14
Correlation between protein abundance and sequence conservation: what do recent experiments say?	14
Editorial Board	14
Discrete roles for Rad54 and Rdh54 during homologous recombination	14
Editorial overview: Regaining architecture and cell cross-talk upon regeneration	14
Architecture of RNA–RNA interactions	14
Songbird germline-restricted chromosome as a potential arena of genetic conflicts	14
Amending the injured heart by in vivo reprogramming	14
Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations	14
Adipose tissue lipid metabolism: lipolysis	13
Editorial overview: The genome in space–time	13
Evolution and molecular bases of reproductive isolation	13
The stem cell zoo for comparative studies of developmental tempo	13
Recent developments in adipose tissue-secreted factors and their target organs	13
A new era of understanding in vivo metabolic flux in thermogenic adipocytes	13
Principles of genome activation in the early embryo	13
Toward a comprehensive view of gene architecture during transcription	13
Cellular plasticity in the neural crest and cancer	13
Brain organoids: the quest to decipher human-specific features of brain development	13
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes	13
Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks	13
In vitro models of human hypoblast and mouse primitive endoderm	12
Epistasis and evolutionary dependencies in human cancers	12
Exploring conditional gene essentiality through systems genetics approaches in yeast	12
Bridging spatial and temporal scales of developmental gene regulation	12
Dissecting nephron morphogenesis using kidney organoids from human pluripotent stem cells	12
Editorial Board	12
Genome folding dynamics during the M-to-G1-phase transition	12
3D chromosomal architecture in germinal center B cells and its alterations in lymphomagenesis	12
Microbial experimental evolution in a massively multiplexed and high-throughput era	12
The role of loop extrusion in enhancer-mediated gene activation	11
Alternative splicing in addiction	11
When 3D genome changes cause disease: the impact of structural variations in congenital disease and cancer	11
Editorial Board	11
The genetic landscape of cardiovascular left–right patterning defects	11
The metabolic baton: conducting the dance of N6-methyladenosine writing and erasing	11
In search of conserved principles of planar cell polarization	11
An extending ATR–CHK1 circuitry: the replication stress response and beyond	11
Chromosome organization in 4D: insights from C. elegans development	11
Mechanism of mitotic recombination: insights from C. elegans	11
Phase separation and inheritance of repressive chromatin domains	11
Jack of all trades versus master of one: how generalist versus specialist strategies of transposable elements relate to their horizontal transfer between lineages	11
Editorial Board	11
Topical section: embryonic models (2023) for Current Opinion in Genetics & Development	11
Proliferation and dissemination of killer meiotic drive loci	11
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer	11
Polycomb complexes in MLL–AF9-related leukemias	11
The role of tissue maturity and mechanical state in controlling cell extrusion	11
The role of SAF-A/hnRNP U in regulating chromatin structure	11
The power of proximity: mechanisms and biological roles of transvection	11
Paternal genome elimination: patterns and mechanisms of drive and silencing	11
Reconstitution of reproductive organ system that produces functional oocytes	11
Recent advances in stem cell-based blastocyst models	10
Principles of long-range gene regulation	10
Editorial Board	10
Transposon persistence and control in germ cells	10
Prospects for precision genetic medicine in congenital heart disease	10
R-loop homeostasis in genome dynamics, gene expression and development	10
Cellular diversity and developmental hierarchy in the planarian nervous system	10
Can we stop one heart from breaking: triumphs and challenges in cardiac reprogramming	10
Timing mechanisms: insights from comparative neural differentiation systems	10
Spliceosome complex and neurodevelopmental disorders	10
Hijacked enhancer–promoter and silencer–promoter loops in cancer	10
Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions	9
Ex situ-armus: experimental models for combating respiratory dysfunction	9
Mitochondrial curation for the next generation	9
Pediatric CNS cancer genomics and immunogenomics	9
Unlocking regeneration: how partial reprogramming resembles tissue healing	9
To splice or not to splice: pseudoexons in neurological disease and opportunities for intervention	9
Corneal regeneration: insights in epithelial stem cell heterogeneity and dynamics	9
Recent insights into the in vitro culture systems for mammalian embryos	9
Quantitative mapping of the mammalian epitranscriptome	9
Clinical Perspectives in Epitranscriptomics	9
Experimental evolution of drug resistance in human fungal pathogens	9
Epigenetic dynamics during germline development: insights from Drosophila and C. elegans	8
Modification of the RNA methylome in neurodevelopmental disorders	8
Xenotransplantation — a shortcut to construct tissue complexity in organoids	8
Chromosomal instability as a source of genomic plasticity	8

The WRN helicase: resolving a new target in microsatellite unstable cancers	8
Interplay of transposable elements and ageing: epigenetic regulation and potential epitranscriptomic influence	8
Evolutionary neurogenomics at single-cell resolution	8
Temporal patterning of the vertebrate developing neural tube	8
Female meiotic drive in plants: mechanisms and dynamics	8
Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity	8
Pluripotent stem cell–derived mesenchymal stem cells for therapeutic applications, developmental study, and cancer research	8
Transgenerational epigenetic control of constitutive heterochromatin, transposons, and centromeres	7
The ribonucleoprotein network of the nucleus: a historical perspective	7
NOVA1/2 genes and alternative splicing in neurodevelopment	7
Circuit integration by transplanted human neurons	7
Factors that determine cell type–specific CTCF binding in health and disease	7
Overcoming muscle stem cell aging	7
The ever-growing world of gastruloids: autogenous models of mammalian embryogenesis	7
Recombination-dependent replication: new perspectives from site-specific fork barriers	7
Editorial Board	7
Narrative engineering of the liver	7
Linking mitochondria metabolism, developmental timing, and human brain evolution	7
Insights into multilevel spatial regulation within the root stem cell niche	7
Advancements in inner ear development, regeneration, and repair through otic organoids	7
Do sex-linked male meiotic drivers contribute to intrinsic hybrid incompatibilities? Recent empirical studies from flies and rodents	7
Network models of chromatin structure	7
Recent insights into the evolution of mutation rates in yeast	7
Concepts, mechanisms and implications of long-term epigenetic inheritance	7
Vascular and immune interactions in islets transplantation and 3D islet models	7
Mechanisms of regulatory evolution in yeast	7
Safeguarding the epigenome through the cell cycle: a multitasking game	6
Engineering immune organoids to regenerate host immune system	6
A lifelong duty: how Xist maintains the inactive X chromosome	6
Extending the spectrum in aortopathy: stenosis to aneurysm	6
Early central nervous system development and neuron regeneration	6
Editorial Board	6
Editorial overview: Early embryonic development models: back to the beginning	6
Plasticity of muscle stem cells in homeostasis and aging	6
Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe	6
Deciphering the role of structural variation in human evolution: a functional perspective	6
RAD51 paralog function in replicative DNA damage and tolerance	6
Adipocyte plasticity in tissue regeneration, repair, and disease	6
Decoding the role of tRNA modifications in cancer progression	6
Molecular mechanisms of the specialization of human synapses in the neocortex	6
Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation	6
Rethinking chromatin accessibility: from compaction to dynamic interactions	6
A new era in neuromuscular junction research: current advances in self-organized and assembled in vitro models	6
Therapeutic index of targeting select chromatin complexes in human cancer patients	6
When and why are mitochondria paternally inherited?	6
Multi-scale dynamics of heterochromatin repair	6
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation	6
Human trophoblast stem cell-state acquisition from pluripotent stem cells and somatic cells	6
Rewiring for movements in meiotic prophase: regulators, roles, and evolutionary pathways	5
Evolutionary innovations in the primate dopaminergic system	5
It’s all in the combination: decoding the epigenome for cancer research and diagnostics	5
Insights into homology search from cryo-EM structures of RecA-DNA recombination intermediates	5
RNA editing and immune control: from mechanism to therapy	5
Editorial overview: New insights into epithelial dynamics: From tissue homeostasis to morphogenesis	5
Human blastoid as an in vitro model of human blastocysts	5
How our brains are built: emerging approaches to understand human-specific features	5
Revealing epithelial morphogenetic mechanisms through live imaging	5
Recombination and restart at blocked replication forks	5
Statistical models of the genetic etiology of congenital heart disease	5
Editorial overview: Understanding the biology of cancer genomes in the context of DNA, RNA, histone marks, and 3D chromatin organization	5
Editorial Board	5
Evolutionary dynamics between transposable elements and their host genomes: mechanisms of suppression and escape	5
Editorial overview: Fat tissue in focus: Assembled deeply insightful perspectives on state-of-the-art explorations	5
Adipocyte gene expression in obesity — insights gained and challenges ahead	5
Editorial overview: How to generate and maintain organs–organoids, regeneration, and beyond	5
Recent progress in understanding the genomic architecture of sexual conflict	5
Transcription-Export complex in neurodevelopmental disorders	5
Replication timing and transcriptional control: beyond cause and effect — part IV	5
Interplay between Sae2 and Rif2 in the regulation of Mre11-Rad50 activities at DNA ends	5
Recent advances in RNA-based therapeutics for neurodevelopmental disorders	5
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia	5
RNA in chromatin organization and nuclear architecture	5