Current Opinion in Biotechnology

Papers
(The median citation count of Current Opinion in Biotechnology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Editorial Board277
Editorial Board219
Systems biology-based analysis of cell-free systems175
Corrigendum to “Methylotrophs: from C1 compounds to food” [Curr Opin Biotechnol 75 (2022) 102685]166
How much could improving photosynthesis increase crop yields? A call for systems-level perspectives to guide engineering strategies115
Recent progress in the synthesis of advanced biofuel and bioproducts104
Stem cells characterization: OMICS reinforcing analytics100
Bioelectrosynthesis systems96
The osteo-angiogenic signaling crosstalk for bone regeneration: harmony out of complexity95
Synthetic biology advances towards a bio-based society in the era of artificial intelligence94
The journey of a lifetime — development of Pfizer’s COVID-19 vaccine91
Tumor lipid metabolism: a mechanistic link between diet and cancer progression90
Cell-free technologies for biopharmaceutical research and production86
Applications of artificial intelligence to enzyme and pathway design for metabolic engineering83
Creating value from purple phototrophic bacteria via single-cell protein production83
Circadian rhythms and meal timing: impact on energy balance and body weight82
Whole-plant phenotypic engineering: moving beyond ratios for multi-objective optimization of nutrient use efficiency79
Editorial Board77
Leveraging rAAV bioprocess understanding and next generation bioanalytics development75
Innovations and trends in antibody repertoire analysis75
Engineered living bioassemblies for biomedical and functional material applications75
Engineering of new-to-nature ribosomally synthesized and post-translationally modified peptide natural products73
Single-cell analysis opens a goldmine for plant functional studies72
Engineering the plant microbiota in the context of the theory of ecological communities71
Deep learning in regulatory genomics: from identification to design69
The plant microbiota: composition, functions, and engineering68
Recent advances, opportunities and challenges in cybergenetic identification and control of biomolecular networks66
Lighting the way: recent developments and applications in molecular optogenetics61
Bridging the gap — biomimetic design of bioelectronic interfaces61
Genetically encoded elastin-like polypeptide nanoparticles for drug delivery59
Emerging technologies for genetic control systems in cellular therapies59
Coupling chemistry and biology for the synthesis of advanced bioproducts59
Fermented food products in the era of globalization: tradition meets biotechnology innovations58
A molecular assessment of the practical potential of DNA-based computation58
Multifaceted metabolic role of infections in the tumor microenvironment55
Emerging trends in production of plant natural products and new-to-nature biopharmaceuticals in yeast55
Computational tools and resources for designing new pathways to small molecules55
Engineering of the genetic code53
Regulatory roles of microRNAs in insect pests: prospective targets for insect pest control51
Biocatalytic cascade transformations for the synthesis of C-nucleosides and N-nucleoside analogs51
Dietary microalgae on poultry meat and eggs: explained versus unexplained effects51
Mass spectrometry imaging methods for visualizing tumor heterogeneity51
2-hydroxyglutarate rides the cancer-immunity cycle50
Contemporary aquaculture: implications for human nutrition49
Machine learning to navigate fitness landscapes for protein engineering48
Perspectives for self-driving labs in synthetic biology48
Using genome and transcriptome analysis to elucidate biosynthetic pathways46
Editorial Board45
Editorial overview: Biotechnological insights of marine and terrestrial microbiome45
Editorial Board44
Plant synthetic biology as a tool to help eliminate hidden hunger44
Computational approaches to understanding nutrient metabolism and metabolic disorders44
Tissue engineering in the agri-food industry: current status, socio-economic overview and regulatory compliance43
Harnessing in vitro platforms for natural product research: in vitro driven rational engineering and mining (iDREAM)43
Toolboxes for plant systems biology research43
Advancing in vivo reprogramming with synthetic biology42
Integration of omics data to unravel root microbiome recruitment42
Reducing crop losses by gene-editing control of organ developmental physiology42
Analytics of host cell proteins (HCPs): lessons from biopharmaceutical mAb analysis for Gene therapy products41
Anaerobic fluorescent reporters for cell identification, microbial cell biology and high-throughput screening of microbiota and genomic libraries39
Sourcing DNA parts for synthetic biology applications in plants39
Matching diverse feedstocks to conversion processes for the future bioeconomy39
Recent advances in biotechnology for marine enzymes and molecules39
The potential of amoeba-based processes for natural product syntheses39
Impact of anthropogenic contamination on glacier surface biota38
Redox as a bioprocess parameter: analytical redox quantification in biological therapeutic production38
Editorial overview: Emerging routes to sustainable energy capture and conversion into value-added products38
Synthetic biology approaches for dynamic CHO cell engineering38
Corrigendum to: “Design, construction, and application of noncanonical redox cofactor infrastructures” [Curr Opin Biotechnol 84 (2023) 103019]38
Understanding atmospheric intercontinental dispersal of harmful microorganisms37
Metabolic and cellular engineering for the production of natural products37
Synthetic apomixis: the beginning of a new era37
Single-cell omics analysis with genome-scale metabolic modeling37
Low-cost, point-of-care biomarker quantification37
Overview of dietary assessment methods for measuring intakes of foods, beverages, and dietary supplements in research studies37
Matchmaking at the cell surface using bispecifics to put cells on their best behavior36
Programmable synthetic biology tools for developing microbial cell factories36
Ketogenic regimens for acute neurotraumatic events36
Complexity of subcellular metabolism: strategies for compartment-specific profiling35
Editorial Board35
The aging tumor metabolic microenvironment34
Editorial overview: Nanobiotechnology for immunoengineering34
Synthetic fuels: what are they and where do they come from?34
Engineered methane biocatalysis: strategies to assimilate methane for chemical production33
Synthetic mRNA – emerging new class of drug for tissue regeneration33
Extracellular vesicles as therapeutics for inflammation and infection33
What’s new in single-cell proteomics33
Engineering insect resistance using plant specialized metabolites32
Editorial Board32
Strategies and opportunities for engineering antifungal peptides for therapeutic applications32
Potential use of microbial engineering in single-cell protein production32
Avoidance of detrimental defense responses in beneficial plant–microbe interactions32
Targeting ripening regulators to develop fruit with high quality and extended shelf life32
Next-generation biological vector platforms for in vivo delivery of genome editing agents32
Editorial overview: Biotechnology to help understand and harness biotic interactions in plants32
Antigen-specific nanomedicines for the treatment of autoimmune disease: target cell types, mechanisms and outcomes32
Bridging the gender gap in autoimmunity with T-cell–targeted biomaterials31
Engineering bacterial warriors: harnessing microbes to modulate animal physiology31
Strategies for uncovering stable isotope tracing patterns between cell populations31
Challenges and future perspectives for high-throughput chimeric antigen receptor T cell discovery31
Optimizing the value of bioinks and robotics to advance in vivo bioprinting30
Beyond vancomycin: recent advances in the modification, reengineering, production and discovery of improved glycopeptide antibiotics to tackle multidrug-resistant bacteria30
Inhalable mRNA vaccines for respiratory diseases: a roadmap30
Practical monitoring technologies for cells and substrates in biomanufacturing30
Biotechnology approaches for natural product discovery, engineering, and production based on Burkholderia bacteria30
Biohybrid approaches to interface with the nervous system: the best of both worlds30
Machine learning for predicting phenotype from genotype and environment30
Can digital twin efforts shape microorganism-based alternative food?29
Large-scale production of enzymes for biotechnology uses29
De novo domestication: retrace the history of agriculture to design future crops29
Microbiological food safety considerations in shelf-life extension of fresh fruits and vegetables29
Advances in engineering substrate scope of Pseudomonas cell factories29
Editorial overview: Tissue, cell, and pathway engineering29
Analytical tools for unravelling the metabolism of gas-fermenting Clostridia29
Editorial Board29
Engineering plant–microbe communication for plant nutrient use efficiency28
Recent trends in the modification of polyphenolic compounds using hydroxylation and glycosylation28
Two in one: the emerging concept of bifunctional antibodies28
Cell-free synthesis of industrial chemicals and biofuels from carbon feedstocks28
Quantitative and analytical tools to analyze the spatiotemporal population dynamics of microbial consortia28
An integrated eco-evolutionary framework to predict population-level responses of climate-sensitive pathogens28
In situ characterization of the tumor microenvironment28
Sustainability in food-waste reduction biotechnology: a critical review28
Senescent cells in tissue engineering28
Life stage-dependent genetic traits as drivers of plant–herbivore interactions28
Engineering next-generation chimeric antigen receptor-T cells: recent breakthroughs and remaining challenges in design and screening of novel chimeric antigen receptor variants27
Corrigendum to “Unraveling the mechanobiology of immune cells” [Curr Opin Biotechnol 66 (2020) 236-245]27
Searching for the optimal microbial factory: high-throughput biosensors and analytical techniques for screening small molecules27
General framework for enzyme-photo-coupled catalytic system toward carbon dioxide conversion27
Achieving net zero CO2 emission in the biobased production of reduced platform chemicals using defined co-feeding of methanol27
Clustered regularly interspaced short palindromic repeats tools for plant metabolic engineering: achievements and perspectives26
Genetic and process engineering for polyhydroxyalkanoate production from pre- and post-consumer food waste26
Advances in engineering and optimization of transcription factor-based biosensors for plug-and-play small molecule detection26
Biologics-based degraders — an expanding toolkit for targeted-protein degradation25
Advances in engineering algae for biofuel production25
Decoding dissolved information: environmental DNA sequencing at global scale to monitor a changing ocean25
Division of labor for substrate utilization in natural and synthetic microbial communities25
Computational models in systems biology: standards, dissemination, and best practices25
Progress and challenges in the translation of cancer nanomedicines25
Mycotoxin risks are lower in biotech corn25
Force in numbers: high-throughput screening approaches to unlock microbial transport25
Engineering bacteria for cancer immunotherapy24
Hitting the sweet spot with capillary electrophoresis: advances in N-glycomics and glycoproteomics24
Building mutational bridges between carbohydrate-active enzymes24
In vivo 2H/13C flux analysis in metabolism research24
Integrating bioprinting and optogenetic technologies for precision plant tissue engineering24
Chemical speciation of trace metals in mammalian cell culture media: looking under the hood to boost cellular performance and product quality24
Machine learning applications to improve flavor and nutritional content of horticultural crops through breeding and genetics24
Approaches for a more microbiologically and chemically safe dried fruit supply chain24
Path to zero emission of nitrous oxide in sewage treatment: is nitrification controllable or avoidable?24
Proteomics insights into the fungal-mediated bioremediation of environmental contaminants24
Quantifying nanoparticle delivery: challenges, tools, and advances24
Carbon recycling with synthetic CO2 fixation pathways24
RNAs — a new frontier in crop protection23
Pleiotropy, a feature or a bug? Toward co-ordinating plant growth, development, and environmental responses through engineering plant hormone signaling23
Drugging the microbiome and bacterial live biotherapeutic consortium production23
Getting better all the time — recent progress in the development of CRISPR/Cas-based tools for plant genome engineering23
Cell-free enzyme cascades — application and transition from development to industrial implementation23
Enzymes in biotechnology: Critical platform technologies for bioprocess development23
Cellobiose dehydrogenase in biofuel cells23
Engineering microbial consortia with rationally designed cellular interactions23
Technologies for the discovery of G protein–coupled receptor–targeting biologics22
Transcription factor-based biosensors: a molecular-guided approach for natural product engineering22
Engineering organoids as cerebral disease models22
Cytochromes P450 in the biocatalytic valorization of lignin22
Continuous biomanufacturing with microbes — upstream progresses and challenges22
Editorial Board22
Biomolecular feedback controllers: from theory to applications22
Combining enzyme and metabolic engineering for microbial supply of therapeutic phytochemicals22
Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces21
Editorial overview: Tissue, cell and pathway engineering: bioinspired, biomimetic and hybrid neural interfaces21
Antimicrobial polymeric biomaterials based on synthetic, nanotechnology, and biotechnological approaches21
Microbial production of chemicals driven by CRISPR-Cas systems21
Utilizing cross-species co-cultures for discovery of novel natural products21
Recent advances in the biological depolymerization and upcycling of polyethylene terephthalate21
Time to integrate biotechnological approaches into fish gut microbiome research21
Industrial potential of the enzymatic synthesis of nucleoside analogs: existing challenges and perspectives21
Optogenetics in medicine: innovations and therapeutic applications21
SgRNA engineering for improved genome editing and expanded functional assays20
Technoeconomic analysis for near-term scale-up of bioprocesses20
Sharp solutions to cleave plant fibers20
The double life of CRISPR–Cas1320
Engineering ribosomally synthesized and posttranslationally modified peptides as new antibiotics20
Engineered microbial living matter for diagnostics, prevention, and therapy20
Microalgal and bacterial auxin biosynthesis: implications for algal biotechnology20
Filamentous fungi for future functional food and feed20
Food industry side streams: an unexploited source for biotechnological phosphorus upcycling20
Artificial intelligence: a solution to involution of design–build–test–learn cycle19
Surveilling cellular vital signs: toward label-free biosensors and real-time viability assays for bioprocessing19
Petrosia ficiformis (Poiret, 1789): an excellent model for holobiont and biotechnological studies19
Editorial overview: 21st Century solutions for crop improvement19
Bio-integrative design of the neural tissue-device interface19
Cell–nano interactions of polydopamine nanoparticles19
Identification of novel membrane proteins for improved lignocellulose conversion19
Cutting-edge plant natural product pathway elucidation19
Ultrasonographic features of ovarian morphology capture nutritional and metabolic influences on the reproductive axis: implications for biomarker development in ovulatory disorders19
Rational design of peptide-based implants for corneal bioengineering19
Tissue-resident macrophages — early passengers or drivers in the tumor niche?18
Recent advances in synthetic glycoengineering for biological applications18
Cell-free chemoenzymatic cascades with bio-based molecules18
Precise control methods of the physicochemical properties of nanoparticles for personalized medicine18
Coupling electrochemical CO2 reduction to microbial product generation – identification of the gaps and opportunities18
Dissecting postharvest chilling injury through biotechnology18
Engineering metalloproteinase inhibitors: tissue inhibitors of metalloproteinases or antibodies, that is the question18
Toward manipulating serotonin signaling via the microbiota–gut–brain axis18
Process intensification in continuous flow biocatalysis by up and downstream processing strategies18
Phage biocontrol for reducing bacterial foodborne pathogens in produce and other foods18
Spatial omics techniques and data analysis for cancer immunotherapy applications18
Cell-free protein synthesis systems for vaccine design and production18
Editorial overview: Unlocking the secrets of nongenetic plasticity, one cell at a time17
Transdermal sensing: in-situ non-invasive techniques for monitoring of human biochemical status17
Integrative metabolic flux analysis reveals an indispensable dimension of phenotypes17
Coral holobionts and biotechnology: from Blue Economy to coral reef conservation17
Adaptive biomimicry: design of neural interfaces with enhanced biointegration17
Constructing next-generation CRISPR–Cas tools from structural blueprints17
Coupling and uncoupling growth and product formation for producing chemicals17
Pseudomonas putida as a synthetic biology chassis and a metabolic engineering platform17
Harnessing the omics revolution to address the global biodiversity crisis17
Editorial Board17
The dawn of interoperating spatial models in cell biology17
Biological recognition and cellular trafficking of targeted RNA-lipid nanoparticles17
Biotechnological interventions in reducing losses of tropical fruits and vegetables17
Microenvironmental effects can masquerade as substrate channelling in cascade biocatalysis17
Thermodynamic tools for more efficient biotechnological processes: an example in poly-(3-hydroxybutyrate) production from carbon monoxide16
N-acetyl-aspartate metabolism at the interface of cancer, immunity, and neurodegeneration16
Advances in mass spectrometry-enabled multiomics at single-cell resolution16
Transient electronics: new opportunities for implantable neurotechnology16
Advances in designed bionanomolecular assemblies for biotechnological and biomedical applications16
AuxSynBio: synthetic biology tools to understand and engineer auxin16
Different avenues for progress apply to drought tolerance, water use efficiency and yield in dry areas16
Biosensor-enabled pathway optimization in metabolic engineering16
Editorial overview: Pharmaceutical biotechnology16
The tier system: a host development framework for bioengineering16
Harnessing Fe(II)/α-ketoglutarate-dependent oxygenases for structural diversification of fungal meroterpenoids16
Antifungal natural products16
Advances in genome-scale metabolic models of industrially important fungi16
Engineering of citrus to obtain huanglongbing resistance16
Beyond co-expression: pathway discovery for plant pharmaceuticals15
Design and fabrication of field-deployable microbial biosensing devices15
Using systems metabolic engineering strategies for high-oil maize breeding15
Advances in vascularization and innervation of constructs for neural tissue engineering15
Does the surface charge of the nanoparticles drive nanoparticle–cell membrane interactions?15
Editorial Board15
Diversity: current and prospective secondary metabolites for nutrition and medicine15
Machine learning for synthetic gene circuit engineering15
Carbonic anhydrase for CO2 capture, conversion and utilization15
Personalized gut microbial community modeling by leveraging genome-scale metabolic models and metagenomics15
Mannosylerythritol lipids: production, downstream processing, and potential applications15
Principles for designing an optimal mRNA lipid nanoparticle vaccine15
Molecular characterization of HEK293 cells as emerging versatile cell factories15
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