OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Internal Medicine is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
	417
Issue Information	210
	150
Issue Information	149
Corrigendum	136
Genetics of human longevity: From variants to genes to pathways	122
Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon	120
Oral anticoagulation in patients with gastrointestinal bleeding and new‐onset atrial fibrillation: A population‐based registry‐linkage study	108
Regarding: Clinical findings and kidney morphology in chronic kidney disease of unknown cause in India	106
Temporal trends in guideline‐recommended cardiometabolic testing completeness before initiating immune checkpoint inhibitors: A cohort study	101
Association of VKORC1 polymorphisms and major bleedings in patients who are treated with vitamin K antagonists	96
Acetylsalicylic acid use is associated with improved survival in bacteremic pneumococcal pneumonia: A long‐term nationwide study	87
Sociodemographic disparities affect COVID‐19 vaccine uptake in non‐elderly adults with increased risk of severe COVID‐19	85
MASLD and MASH at the crossroads of hepatology trials and cardiorenal metabolic trials	84
Longitudinal changes in regional fat and muscle composition and cardiometabolic biomarkers over 5 years of hormone therapy in transgender individuals	80
	79
Authors reply: IL‐1β/DNA complex elevation distinguishes autoinflammatory disorders from autoimmune and infectious diseases	74
Choosing Wisely in clinical practice: Embracing critical thinking, striving for safer care	73
Genetic characteristics predict response to venetoclax plus hypomethylating agents in relapsed or refractory acute myeloid leukemia	73
Current concepts regarding Graves’ orbitopathy	72
	67
Therapeutic options for human papillomavirus‐positive tonsil and base of tongue cancer	66
Increased risk of osteoporotic fractures and osteoporosis in patients with Addison's disease in Sweden: A nationwide population‐based cohort study	62
Is shrunken pore syndrome also a reality in children?	61
The combination of statin and ezetimibe is safe, effective, and preferable	59

Cardiovascular, cancer, and infection risks of Janus kinase inhibitors in rheumatoid arthritis and ulcerative colitis: A nationwide cohort study	58
Issue Information	55
Early transfusion patterns improve the Molecular International Prognostic Scoring System (IPSS‐M) prediction in myelodysplastic syndromes	55
Authors reply: Standard and advanced echocardiographic study of patients with Paget's disease of bone: Evidence of a Pagetic heart disease?	54
Exceptional longevity in Okinawa: Demographic trends since 1975	54
Respiratory dysfunction three months after severe COVID‐19 is associated with gut microbiota alterations	53
Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial	53
Regarding: Clinical presentation, course, and prognosis of patients with mixed connective tissue disease	53
Classic heat stroke in a desert climate: A systematic review of 2632 cases	51
Long‐term risk of cardiovascular events after COVID‐19 in the Swedish adult population—A matched cohort study	51
Significance of clinical‐immunological patterns and diagnostic yield of biopsies in microscopic polyangiitis and granulomatosis with polyangiitis	51
Authors reply: Dual versus single long‐acting bronchodilator use could raise acute coronary syndrome risk by over 50%	50
Issue Information	50
Authors reply: The interplay of delirium and frailty in hospitalized older adults	49
	49
Six‐fold increased risk of acute pancreatitis in alcohol‐related liver disease compared to matched comparators: A population‐based cohort study	47
Metabolomic markers mediate erythrocyte anisocytosis in older adults: Results from three independent aging cohorts	47
Elevated lipoprotein(a) and progression of aortic stenosis measured by Doppler echocardiography: A population‐based cohort study	46
Glucagon‐like peptide‐1: Are its roles as endogenous hormone and therapeutic wizard congruent?	45
Low‐protein diet for chronic kidney disease: Evidence, controversies, and practical guidelines	44
Antibiotics and mental health: The good, the bad and the ugly	43
Safety and efficacy of moderate‐intensity statin with ezetimibe in elderly patients with atherosclerotic cardiovascular disease	42
CD71 ⁺ erythroid cell expansion in late‐onset systemic lupus erythematosus	41
Patients of 75 years and over with ANCA‐associated vasculitis have a lower relapse risk than younger patients: A multicentre cohort study	39
	38
Is the lower the better in finding the best practical blood pressure goal under antihypertensive treatment?	37
Acknowledgement to Reviewers	37
	37
Switching from subcutaneous to oral semaglutide in type 2 diabetes: A prospective study	35
Unexpected findings in a bright liver	35
	35
UDCA treatment against COVID‐19: Do we have enough clinical evidence for drug repurposing?	34
Alcohol‐induced pancreatitis and alcohol‐related liver disease: Two different phenotypes of alcohol‐related harm or related conditions?	33
Performance of novel collagen turnover biomarkers to detect increased liver stiffness in MASLD	32
Regarding: Alpha‐1 antitrypsin deficiency associated with increased risks of skin cancer, leukemia, and hepatic cancer: A nationwide cohort study	32
Trends, timing, and predictors of alcohol use disorder treatment among US adult cancer survivors	32
Neoehrlichia mikurensis—An emerging opportunistic tick‐borne infection in immunosuppressed patients	32
SARS‐CoV‐2 antibody dynamics over time and risk factors associated with infection and long COVID‐19 symptoms in large working environments	32
Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one‐year randomized controlled trial	30
Ursodeoxycholic acid is associated with a reduction in SARS‐CoV‐2 infection and reduced severity of COVID‐19 in patients with cirrhosis	30
Amiodarone induced thyroid dysfunction: A high cumulative incidence in a nationwide cohort study in Iceland	30
Evaluation of SARS‐CoV‐2 antibody levels on hospital admission as a correlate of protection against mortality	29
The 1923 Nobel Prize for the discovery of insulin in a 100‐year perspective	29
Small fiber neuropathy in hypermobile Ehlers Danlos syndrome/hypermobility spectrum disorder	29
Opportunistic assessment of steatotic liver disease in lung cancer screening eligible individuals	28
Issue Information	28
SGLT2 inhibition in heart failure with reduced or preserved ejection fraction: Finding the right patients to treat	27
Light transmittance in human atrial tissue and transthoracic illumination in rats support translatability of optogenetic cardioversion of atrial fibrillation	27
Metabolic syndrome is associated with breast cancer mortality: A systematic review and meta‐analysis	26
Targeting factor XIIa for therapeutic interference with hereditary angioedema	26

All‐cause and cause‐specific mortality risk and loss in life expectancy associated with incident type 2 diabetes onset age and duration	25
Authors reply: Low vitamin D is a marker for poor health and increased risk for disease – but causality is still unclear in most cases	25
Risk of new‐onset atrial fibrillation—does blood glucose matter?	25
All‐cause and cause‐specific mortality risks associated with calcium supplementation with or without vitamin D: A nationwide population‐based study	25
Authors reply: Six‐fold increased risk of acute pancreatitis in alcohol‐related liver disease compared to matched comparators	25
Gastrointestinal function in diabetes is affected regardless of asymptomatic appearance	24
Choosing oral antihyperglycaemic drugs in people living with Type 2 diabetes and severe chronic kidney disease	24
Long‐term glucocorticoids in relation to the metabolic syndrome and cardiovascular disease: A systematic review and meta‐analysis	24
Delirium and frailty in older adults: Clinical overlap and biological underpinnings	23
Authors reply: Obesity treatment in adolescents and adults in the era of personalized medicine	23
Risk of fractures and postfracture mortality in 3980 people with primary biliary cholangitis: A population‐based cohort study	23
Real‐world evidence for the effectiveness of vitamin D supplementation in reduction of total and cause‐specific mortality	23
Randomized clinical trial of BCG vaccine in patients with convalescent COVID‐19: Clinical evolution, adverse events, and humoral immune response	23
Regarding: Time to initiation of extracorporeal membrane oxygenation in conventional cardiopulmonary resuscitation affects the patient survival prognosis	23
Issue Information	23
The clinical and molecular cardiometabolic fingerprint of an exploratory psoriatic arthritis cohort is associated with the disease activity and differentially modulated by methotrexate and apremilast	23
SYMPOSIUM: When is too much too much and too little too little: Scientific evidence of limited workup	23
The yin–yang between clonal hematopoiesis of indeterminate potential and autoimmune diseases	23
Preexisting symptoms increase the risk of developing long COVID during the SARS‐CoV‐2 pandemic	22
Obesity treatment in adolescents and adults in the era of personalized medicine	22
Systemic neutrophil activation and N ‐formyl methionine‐formyl peptide receptor‐1 signaling define inflammatory endotypes in rheumatoid arthritis‐associa	22
Colonoscopy findings after increasing two‐stool faecal immunochemical test (FIT) cut‐off: Cross‐sectional analysis of the SCREESCO randomized trial	22
Optimizing the vaginal microbiome as a potential strategy to reduce heterosexual HIV transmission	21
Romosozumab versus denosumab in long‐term users of glucocorticoids: A pilot randomized controlled trial	21
Calcitonin gene‐related peptide (CGRP) is a key molecule released in acute migraine attacks—Successful translation of basic science to clinical practice	21
Lessons from 20 years with COX‐2 inhibitors: Importance of dose–response considerations and fair play in comparative trials	21
Blood metabolite profiles linking dietary patterns with health—Toward precision nutrition	21
Audiovisual gamma stimulation for the treatment of neurodegeneration	21
	20
Long‐term risk of heart failure and other adverse cardiovascular outcomes in primary Sjögren's syndrome	20
Bone fractures in primary biliary cholangitis	20
	20
Low‐density lipoprotein cholesterol cannot be too low after a myocardial infarction	20
Progressive decrease of the healthcare impact of the post‐COVID condition after the first disease wave in Lombardy, Italy	19
Effects of letrozole therapy in former users of anabolic steroids: A randomized clinical trial	19
Genetic risk factors and clinical manifestations of systemic lupus erythematosus: Large‐scale analysis of genetic predisposition and disease subtypes	19
Issue Information	19
Spinocerebellar ataxia type 4 is caused by a GGC expansion in the ZFHX3 gene and is associated with prominent dysautonomia and motor neuron signs	19
Incidence and severity of COVID‐19 in adults with and without HIV diagnosis	18
Circadian and ultradian rhythms: Clinical implications	18
	18
Regarding: Delirium and frailty in older adults: Clinical overlap and biological underpinnings	18
Working in value‐discrepant environments inhibits clinicians’ ability to provide compassion and reduces well‐being: A cross‐sectional study	18
Issue Information	18
Epidemiology and outcomes of alpha‐1 antitrypsin deficiency in Sweden 2002–2020: A population‐based cohort study of 2286 individuals	18
Minimal hepatic encephalopathy is associated with a higher risk of overt hepatic encephalopathy and poorer survival	18
Hypocretins (orexins): The ultimate translational neuropeptides	18
Regarding: Six‐fold increased risk of acute pancreatitis in alcohol‐related liver disease compared to matched comparators	18
Correction to “Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial”	17
Management and outcomes of patients with chest pain and psychiatric disorders in the era of high‐sensitivity cardiac troponins	17
No association between sleep apnea, nocturnal blood pressure dipping, and cognitive performance among Swedish adults aged 50–65 years	17
Tadalafil use is associated with a lower incidence of Type 2 diabetes in men with benign prostatic hyperplasia: A population‐based cohort study	17
Cardiovascular effects of TMAO and other toxic metabolites of the intestinal microbiome	16
In memoriam: Anders Ekbom (1947‒2024)	16
Effects of SGLT2 inhibitors on transplant survival and key clinical outcomes in heart transplant recipients with diabetes	16
	16
Dilated cardiomyopathy and chronic cardiac inflammation: Pathogenesis, diagnosis and therapy	16
Treatment strategies to reduce cardiovascular risk in persons with chronic kidney disease and Type 2 diabetes	16
Bilateral inferior petrosal sinus sampling in the differential diagnosis of ACTH‐dependent Cushing's syndrome: A reappraisal	16
Beyond the liver: The role of neurotensin in nonalcoholic fatty liver disease	15
Plasma lipopolysaccharide‐binding protein is a biomarker for future venous thromboembolism: Results from discovery and validation studies	15
Race and ethnicity dynamics in survival to 100 years in the United States	15
Acknowledgment to reviewers	15
Splenectomy reappraised: Bridging the gap in immune cytopenia treatment paradigms	15
	15
Intravenous immunoglobulins in the treatment of post‐COVID: A case–control study	14
Adherence to guideline‐recommended care of late‐onset hypertension in females versus males: A population‐based cohort study	14
Issue Information	14
Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritis	14
Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health	14
Issue Information	14
Nationwide study of trends in physician partner choice for childbearing unions	14
Does diet influence aging? Evidence from animal studies	14
Post COVID‐19 condition diagnosis: A population‐based cohort study of occurrence, associated factors, and healthcare use by severity of acute infection	14
	14
Altered T‐cell subset distribution in the viral reservoir in HIV‐1‐infected individuals with extremely low proviral DNA (LoViReTs)	13
Authors reply: Evaluation of SARS‐CoV‐2 antibody levels on hospital admission as a correlate of protection against mortality	13
Has mortality in the United States returned to pre‐pandemic levels? An analysis of provisional 2023 data	13
The first wave of COVID‐19 and concurrent social restrictions were not associated with a negative impact on mental health and psychiatric well‐being	13
Clostridium difficile and other adverse events from overprescribed antibiotics for acute upper respiratory infection	12

Tailored clinical management after blinded statin challenge improved the lipid control in coronary patients with self‐perceived muscle side effects	12
Performance‐enhancing drugs and the Olympics	12
Disease‐modifying antirheumatic drugs and risk of thyroxine‐treated autoimmune thyroid disease in patients with rheumatoid arthritis	12
Prevalence and prognostic value of electrocardiographic abnormalities in hypokalemia: A multicenter cohort study	12
Kidney function decline improves after lithium discontinuation	12
Ignoring the planet: A critical blind spot for research on ageing	12
Diagnostic performance of a new framework for identifying obesity	12
The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation	11
Gaucher disease, state of the art and perspectives	11
Can we cure diabetic kidney disease? Present and future perspectives from a nephrologist's point of view	11
Issue Information	11
The role of extracellular histones in COVID‐19	11
Change in healthcare utilization before and after COVID‐19 using data from 1.5 million individuals	11
Issue Information	11
Intercontinentally validated diagnostic criteria for secondary hemophagocytic lymphohistiocytosis—So welcome!	11
Therapeutic innovations to counter antimicrobial‐resistant infections and antimicrobial peptides	11
Advances in the Omicron variant development	11
Issue Information	11
Mass changes in remnant cholesterol and LDL cholesterol explain part of the results of gemfibrozil and non‐gemfibrozil fibrate trials	10
The step count conundrum	10
Issue Information	10
	10
Increased ferroptosis in leukocytes from preeclamptic women involving the long non‐coding taurine upregulated gene 1 (TUG1)	10
The long and winding road of COVID‐19 in survivors of hospitalisation: Symptoms trajectory and predictors of long COVID	10
Low positive and borderline negative transglutaminase antibody levels are frequently associated with a coeliac disease diagnosis	10
The value of values alignment in healthcare	10
Diagnostic performance of ¹⁸F‐FDG‐PET/CT in inflammation of unknown origin: A clinical series of 317 patients	10
Issue Information	10
	10
Clinical findings and kidney morphology in chronic kidney disease of unknown cause in India	9
Regarding: Apixaban, edoxaban and rivaroxaban, but not dabigatran, are associated with higher mortality compared to vitamin K antagonists	9
Reducing the risks of nuclear war – The role of health professionals	9
Authors reply: Clinical presentation, course, and prognosis of patients with mixed connective tissue disease	9
Adverse effects of obesity on overall health, quality of life, and related physical health metrics: A cross‐sectional and longitudinal study from the All of Us Research Program	9
Fasting intervention and its clinical effects on the human host and microbiome	9
Issue Information	9
	9
Regarding: Time to initiation of extracorporeal membrane oxygenation in conventional cardiopulmonary resuscitation affects the patient survival prognosis	9
Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing	9
Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management	9
	9
Regarding: Low vitamin D is a marker for poor health and increased risk for disease: But causality is still unclear in most cases	9
Long‐term durability of antibody responses after SARS‐CoV‐2 vaccination and influencing factors	9
Iron deficiency screening is a key issue in chronic inflammatory diseases: A call to action	9
Circulating extracellular choline acetyltransferase regulates inflammation	8
Human white adipose tissue: A highly dynamic metabolic organ	8
Issue Information	8
Low antispike antibody levels correlate with poor outcomes in COVID‐19 breakthrough hospitalizations	8
The age‐dependent association of Life's Simple 7 with transitions across cognitive states after age 60	8
Achilles tendon ultrasonography in familial hypercholesterolemia: A sub‐study of the LIpid transPort disorders Italian GEnetic Network (LIPIGEN)	8
Deep brain stimulation for Parkinson's disease	8
Oxidized high‐density lipoprotein associates with cardiometabolic dysfunction in coronary artery disease and acute coronary syndrome	8
Novel precision medicine approaches and treatment strategies in hematological malignancies	8
Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification	8
	8
Urinary phosphate is associated with cardiovascular disease incidence	8
Pyridoxal‐5′‐phosphate: A cost‐effective treatment candidate for hypertensive patients?	8
Splenectomy outcomes in immune cytopenias: Treatment outcomes and determinants of response	8
High incidence of immune‐mediated inflammatory diseases in sepsis survivors: A nationwide exposed‐nonexposed epidemiological study	8
Factors associated with severe or fatal clinical manifestations of SARS‐CoV‐2 infection after receiving the third dose of vaccine	7
Incidence and survival of haemophagocytic lymphohistiocytosis: A population‐based cohort study from England	7
The future of healthcare‐associated infection surveillance: Automated surveillance and using the potential of artificial intelligence	7
Age‐related cardiovascular disease in Down syndrome: A population‐based matched cohort study	7
Cardiorespiratory dysautonomia in post‐COVID‐19 condition: Manifestations, mechanisms and management	7
Issue Information	7
Regarding: Time to initiation of extracorporeal membrane oxygenation in conventional cardiopulmonary resuscitation affects the patient survival prognosis	7
Parallel testing of liquid biopsy (ctDNA) and tissue biopsy samples reveals a higher frequency of EZH2 mutations in follicular lymphoma	7
Regarding: Systolic blood pressure targets below 120 mm Hg are associated with reduced mortality: A meta‐analysis	7
Is the correction of micronutrient deficiencies the next step in heart failure management?	7
Vitamin D–binding protein, total, “nonbioavailable,” bioavailable, and free 25‐hydroxyvitamin D, and mortality in a large population‐based cohort of older adults	7
Circulating markers of extracellular matrix remodelling in severe COVID‐19 patients	7
Only as strong as the weakest link: Adrenal insufficiency in the COVID‐19 storm	7
Chest x‐ray aortic size and risk of death and cardiovascular disease in older Chinese: Guangzhou biobank cohort study	7
Bacterial meningitis: Aetiology, risk factors, disease trends and severe sequelae during 50 years in Sweden	7
Malmö POTS symptom score: Assessing symptom burden in postural orthostatic tachycardia syndrome	7
Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta‐analyses	7
Impact of nutritional support routes on mortality in acute pancreatitis: A network meta‐analysis of randomized controlled trials	7
Adherence to a Mediterranean lifestyle improves metabolic status in coronary heart disease patients: A prospective analysis from the CORDIOPREV study	7
Enrichment of rare variants of BIN1 but not APOE genes in Chinese patients with Parkinson's disease	7
Impact of cancer on the mortality of patients with idiopathic inflammatory myopathies by flexible parametric multistate modelling	7
Long sleep duration pattern is associated with increased cardiovascular recurrence: Effect of long‐term Mediterranean diet from the CORDIOPREV study	6
The 2021 KDIGO blood pressure target and the progression of chronic kidney disease: Findings from KNOW‐CKD	6
Janus kinase and calcineurin‐inhibitor combination in anti‐MDA5 dermatomyositis: No significant survival benefit but reassuring safety profile	6
Breaking with the status quo in end‐of‐life care through de‐implementation	6
Lipolysis defect in people with obesity who undergo metabolic surgery	6
Factors influencing the immune response over 15 months after SARS‐CoV‐2 infection: A longitudinal population‐wide study in the Faroe Islands	6
Unrecognized liver cirrhosis is common and associated with worse survival in hepatocellular carcinoma: A nationwide cohort study of 3473 patients	6
High BMI and low cardiorespiratory fitness in adolescence are associated with increased risk of severe bacterial infections in adulthood	6
Health inequalities in the Nordic countries: A comparative overview and update	6
Therapeutic BCG vaccine protects against long COVID: The BATTLE randomized clinical trial	6
Role of NO pathway in the clinical picture of idiopathic systemic capillary leak syndrome	6
Tuberous xanthomatosis is not necessarily associated with increased plasma concentrations of cholestanol in cerebrotendinous xanthomatosis	6
Preoperative prediction of metastatic pheochromocytoma and paraganglioma using clinical, genetic, and biochemical markers: A cohort study	6
Different eGFR markers and prediction of cardiovascular risk	6
Human health and the health of Planet Earth go together	6