Journal of Internal Medicine

Article	Citations
COVID‐19 diagnosis and management: a comprehensive review	829
Clinical and epidemiological characteristics of 1420 European patients with mild‐to‐moderate coronavirus disease 2019	556
Senolytic drugs: from discovery to translation	510
Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID‐19 patients in Michigan, United States	248
Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID‐19)	224
The Mediterranean diet and health: a comprehensive overview	215
Perspective: Vitamin D deficiency and COVID‐19 severity – plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis	163
Prevalence and 6‐month recovery of olfactory dysfunction: a multicentre study of 1363 COVID‐19 patients	154
Prevalence, characteristics and mortality outcomes of obese, nonobese and lean NAFLD in the United States, 1999–2016	143
Cytokine storm syndrome in coronavirus disease 2019: A narrative review	136
Short‐term neuropsychiatric outcomes and quality of life in COVID‐19 survivors	134
Systemic amyloidosis from A (AA) to T (ATTR): a review	133
Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta‐analyses	127
The impact of novel coronavirus COVID‐19 on noncommunicable disease patients and health systems: a review	118
COVID‐19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease?	111
Homocysteine – from disease biomarker to disease prevention	104
Contribution of remnant cholesterol to cardiovascular risk	95
Breathing, speaking, coughing or sneezing: What drives transmission of SARS‐CoV‐2?	94
Immunity to SARS‐CoV‐2 induced by infection or vaccination	91
Insights into disparities observed with COVID‐19	85
Nanotechnology for modern medicine: next step towards clinical translation	84
Advances in the Omicron variant development	81
Mitochondrial disease in children	80
Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer’s disease (MCI and dementia) in primary care: a review and synthesis	73
Direct oral anticoagulant use and risk of severe COVID‐19	72

Elevated markers of gut leakage and inflammasome activation in COVID‐19 patients with cardiac involvement	71
How can dementia and disability be prevented in older adults: where are we today and where are we going?	67
Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death: an analysis of 712 cases	60
Cancer survival statistics for patients and healthcare professionals – a tutorial of real‐world data analysis	60
Racial disparities in COVID‐19 deaths reveal harsh truths about structural inequality in America	60
Current treatment of non‐alcoholic fatty liver disease	59
Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals	59
High frequency of antiphospholipid antibodies in critically ill COVID‐19 patients: a link with hypercoagulability?	54
Targeting Krasg12c‐mutant cancer with a mutation‐specific inhibitor	54
Arterial stiffness in acute COVID‐19 and potential associations with clinical outcome	53
Airway organoids as models of human disease	53
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease	51
Epigenetic regulation of insulin action and secretion – role in the pathogenesis of type 2 diabetes	50
Genetics of coronary artery disease in the post‐GWAS era	48
Strategies for fighting mitochondrial diseases	47
Inflammatory and fibrotic mechanisms in NAFLD—Implications for new treatment strategies	45
Lessons from 20 years with COX‐2 inhibitors: Importance of dose–response considerations and fair play in comparative trials	44
Treatment with proton pump inhibitors increases the risk of secondary infections and ARDS in hospitalized patients with COVID‐19: coincidence or underestimated risk factor?	44
Current and emerging disease‐modulatory therapies and treatment targets for multiple sclerosis	43
Hypocretins (orexins): The ultimate translational neuropeptides	43
Assessment of thirty‐day readmission rate, timing, causes and predictors after hospitalization with COVID‐19	43
Tocilizumab shortens time on mechanical ventilation and length of hospital stay in patients with severe COVID‐19: a retrospective cohort study	43
Adherence to a healthy sleep pattern is associated with lower risks of all‐cause, cardiovascular and cancer‐specific mortality	42
Ethnic differences in adiposity and diabetes risk – insights from genetic studies	41
Long‐term neuropsychiatric outcomes in COVID‐19 survivors: A 1‐year longitudinal study	41
Familial hypercholesterolaemia and COVID‐19: triggering of increased sustained cardiovascular risk	41
BCG scarring and improved child survival: a combined analysis of studies of BCG scarring	41
Alveolar progenitor cells and the origin of lung cancer	41
Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID‐19	41
Half‐year follow‐up of patients recovering from severe COVID‐19: Analysis of symptoms and their risk factors	40
Hypoalbuminemia in COVID‐19: assessing the hypothesis for underlying pulmonary capillary leakage	40
Diagnosis and management of diabetes insipidus for the internist: an update	40
The link between vitamin D and COVID‐19: distinguishing facts from fiction	39
Type 2 diabetes and remission: practical management guided by pathophysiology	38
Gastrointestinal bleeding in hospitalized COVID‐19 patients: a propensity score matched cohort study	38
Current concepts regarding Graves’ orbitopathy	37
Respiratory dysfunction three months after severe COVID‐19 is associated with gut microbiota alterations	36
The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis	36
Outcomes of COVID‐19‐positive acute coronary syndrome patients: A multisource electronic healthcare records study from England	36
Is obesity a manifestation of systemic racism? A ten‐point strategy for study and intervention	35
Acute odynophagia: A new symptom of COVID‐19 during the SARS‐CoV‐2 Omicron variant wave in Sweden	34
Oral anticoagulants for nonvalvular atrial fibrillation in frail elderly patients: insights from the ARISTOPHANES study	34
The Stockholm CREAtinine Measurements (SCREAM) project: Fostering improvements in chronic kidney disease care	34
Psychiatric and neurocognitive consequences of endogenous hypercortisolism	34
The role of environmental exposures and gene–environment interactions in the etiology of systemic lupus erythematous	34
Transthyretin amyloid deposits in lumbar spinal stenosis and assessment of signs of systemic amyloidosis	34
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans	33
Cyclosporine A plus low‐dose steroid treatment in COVID‐19 improves clinical outcomes in patients with moderate to severe disease: A pilot study	33
COVID‐19 and renin‐angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) ‐ Is there any scientific evidence for controversy?	33
Mitochondrial diseases in adults	33

Pediatric obesity—Long‐term consequences and effect of weight loss	32
Remnant cholesterol predicts progression of diabetic nephropathy and retinopathy in type 1 diabetes	32
Humoral response to two doses of BNT162b2 vaccination in people with HIV	32
Seropositivity in blood donors and pregnant women during the first year of SARS‐CoV‐2 transmission in Stockholm, Sweden	31
Increased vulnerability to COVID‐19 in chronic kidney disease	31
Review of cadmium exposure and smoking‐independent effects on atherosclerotic cardiovascular disease in the general population	31
Cardiovascular risk factors and lifestyle behaviours in relation to longevity: a Mendelian randomization study	31
Associations between nutritional frailty and 8‐year all‐cause mortality in older adults: The Salus in Apulia Study	31
Coronary artery calcium scoring: an evidence‐based guide for primary care physicians	30
Inflammatory bowel disease and psoriasis: modernizing the multidisciplinary approach	30
Deep brain stimulation for Parkinson's disease	29
Aspects of colorectal cancer screening, methods, age and gender	29
Induction of specific brain oscillations may restore neural circuits and be used for the treatment of Alzheimer's disease	29
Abnormal thyroid function is common in takotsubo syndrome and depends on two distinct mechanisms: results of a multicentre observational study	29
IL‐15 is a biomarker involved in the development of rapidly progressive interstitial lung disease complicated with polymyositis/dermatomyositis	29
New tuberculosis vaccines: advances in clinical development and modelling	29
Use of proton pump inhibitors and risk of adverse clinical outcomes from COVID‐19: a meta‐analysis	29
Cause of death based on systematic post‐mortem studies in patients with positive SARS‐CoV‐2 tissue PCR during the COVID‐19 pandemic	28
Male reproductive health and intergenerational metabolic responses from a small RNA perspective	28
Prevalence and 24‐month recovery of olfactory dysfunction in COVID‐19 patients: A multicentre prospective study	28
Liver mitochondrial DNA damage and genetic variability of Cytochrome b – a key component of the respirasome – drive the severity of fatty liver disease	28
The circadian syndrome predicts cardiovascular disease better than metabolic syndrome in Chinese adults	28
Clinical predictors of donor antibody titre and correlation with recipient antibody response in a COVID‐19 convalescent plasma clinical trial	27
PCSK9 inhibitors for COVID‐19: an opportunity to enhance the antiviral action of interferon in patients with hypercholesterolaemia	27
Food allergy and hypersensitivity reactions in children and adults—A review	27
COVID‐19 in Latin America and the Caribbean: Two years of the pandemic	27
Association of the metabolic syndrome with mortality and major adverse cardiac events: A large chronic kidney disease cohort	27
Muscle‐strengthening activities and risk of cardiovascular disease, type 2 diabetes, cancer and mortality: A review of prospective cohort studies	26
Developmental regulation of barrier‐ and non‐barrier blood vessels in the CNS	26
Immunogenicity of SARS‐CoV‐2 mRNA vaccine in solid organ transplant recipients	26
Tumour biomarkers: association with heart failure outcomes	26
Vitamin D, respiratory infections, and chronic disease: Review of meta‐analyses and randomized clinical trials	25
PCSK9 is associated with mortality in patients with septic shock: data from the ALBIOS study	25
One‐year persistent symptoms and functional impairment in SARS‐CoV‐2 positive and negative individuals	25
Risk of primary liver cancer in acute hepatic porphyria patients: A matched cohort study of 1244 individuals	25
Gene therapy for ischaemic heart disease and heart failure	25
Human white adipose tissue: A highly dynamic metabolic organ	25
An update on polymyalgia rheumatica	25
The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation	24
Gender‐affirming hormone therapy: An updated literature review with an eye on the future	24
The roles of free iron, heme, haemoglobin, and the scavenger proteins haemopexin and alpha‐1‐microglobulin in preeclampsia and fetal growth restriction	24
Pathogenesis of type 2 diabetes risk in black Africans: a South African perspective	24
Dilated cardiomyopathy and chronic cardiac inflammation: Pathogenesis, diagnosis and therapy	24
Prevalence and severity of coronary artery disease linked to prognosis in psoriasis and psoriatic arthritis patients: a multi‐centre cohort study	23
Post COVID‐19 condition diagnosis: A population‐based cohort study of occurrence, associated factors, and healthcare use by severity of acute infection	23
Obesity in African‐Americans: The role of physiology	23
Antibiotics and mental health: The good, the bad and the ugly	23
The influence of the blood–brain barrier in the treatment of brain tumours	23
Use of the IL‐6R antagonist tocilizumab in hospitalized COVID‐19 patients	23
Postural orthostatic tachycardia syndrome is associated with significant employment and economic loss	23
Is systemic inflammation a missing link between periodontitis and hypertension? Results from two large population‐based surveys	23
A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study	23
Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging	23
Methylprednisolone added to tocilizumab reduces mortality in SARS‐CoV‐2 pneumonia: An observational study	22
Changes in eicosapentaenoic acid and docosahexaenoic acid and risk of cardiovascular events and atrial fibrillation: A secondary analysis of the OMEMI trial	22
Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?	22
Long‐term changes in adipose tissue gene expression following bariatric surgery	21
Epigenetic insights into multiple sclerosis disease progression	21
Hypertension genetics past, present and future applications	21
Lipoprotein(a) and SARS‐CoV‐2 infections: Susceptibility to infections, ischemic heart disease and thromboembolic events	21
Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance	20
ACE inhibitors, angiotensin receptor blockers and endothelial injury in COVID‐19	20
Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis	20
Ursodeoxycholic acid is associated with a reduction in SARS‐CoV‐2 infection and reduced severity of COVID‐19 in patients with cirrhosis	20
So close, and yet so far away: The dichotomy of the specific immune response and inflammation in psoriasis and atopic dermatitis	20
The endocannabinoid system – current implications for drug development	20
Sarcoidosis: Epidemiology and clinical insights	20
Distinct differences in gut microbial composition and functional potential from lean to morbidly obese subjects	20
Genetic and molecular architecture of familial hypercholesterolemia	20
Critical COVID‐19 is associated with distinct leukocyte phenotypes and transcriptome patterns	19
Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real‐life setting: the PROSISA Study	19
Increased fracture risk after discontinuation of anti‐osteoporosis medications among hip fracture patients: A population‐based cohort study	19
Trajectories of care in congenital heart disease – the long arm of disease in the womb	19
Long‐term corticosteroid use, adrenal insufficiency and the need for steroid‐sparing treatment in adult severe asthma	19
Beating the odds with systematic individualized care: Nationwide prospective follow‐up of all patients with COVID‐19 in Iceland	19
Cardiovascular problems associated with IVF therapy	19
The potential of DNA methylation as a biomarker for obesity and smoking	19
Low‐dose computed tomography lung cancer screening: Clinical evidence and implementation research	19
There is no ‘African American Physiology’: the fallacy of racial essentialism	19
Cardiac foetal reprogramming: a tool to exploit novel treatment targets for the failing heart	18

Viral infections and their relationship with catastrophic antiphospholipid syndrome: a possible pathogenic mechanism of severe COVID‐19 thrombotic complications	18
Genetic characteristics predict response to venetoclax plus hypomethylating agents in relapsed or refractory acute myeloid leukemia	18
Technological readiness and implementation of genomic‐driven precision medicine for complex diseases	18
Gut microbiome and amyotrophic lateral sclerosis: A systematic review of current evidence	17
Post‐Covid‐19‐vaccination adverse events and healthcare utilization among individuals with or without previous SARS‐CoV‐2 infection	17
Can we cure diabetic kidney disease? Present and future perspectives from a nephrologist's point of view	17
Malmö POTS symptom score: Assessing symptom burden in postural orthostatic tachycardia syndrome	17
Systemic lupus erythematosus and cardiovascular disease	17
Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3	17
Global guidance for the recognition, diagnosis, and management of tumor‐induced osteomalacia	17
Statin exposure and the risk of dementia in individuals with hypercholesterolaemia	17
Does exercise prevent major non‐communicable diseases and premature mortality? A critical review based on results from randomized controlled trials	17
Low anti‐SARS‐CoV‐2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID‐19 patients	17
Discrepancies between actual weight, weight perception and weight loss intention amongst persons with NAFLD	17
A safe level of alcohol consumption: the right answer demands the right question	16
Impact of the post‐COVID‐19 condition on health care after the first disease wave in Lombardy	16
The pathogenesis of microthrombi in COVID‐19 cannot be controlled by DOAC: NETosis should be the target	16
Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease	16
Endovascular thrombectomy for acute ischemic stroke	16
Clinical features of patients who had two COVID‐19 episodes: a European multicentre case series	16
Telehealth mitigates COPD disease progression compared to standard of care: a randomized controlled crossover trial	16
Incidence and survival of haemophagocytic lymphohistiocytosis: A population‐based cohort study from England	16
Big data in vascular surgery: registries, international collaboration and future directions	16
Iron deficiency screening is a key issue in chronic inflammatory diseases: A call to action	16
Clinical characteristics and outcomes of immunosuppressed patients hospitalized with COVID‐19: experience from London	16
A follow‐up survey of patients with acquired angioedema due to C1‐inhibitor deficiency	15
Antibody‐dependent neutralizing capacity of the SARS‐CoV‐2 vaccine BNT162b2 with and without previous COVID‐19 priming	15
4D flow MRI hemodynamic biomarkers for cerebrovascular diseases	15
Twenty‐five years of biologicals in IBD: What´s all the hype about?	15
Homocysteine elevation in givosiran treatment: Suggested ALAS1 siRNA effect on cystathionine beta‐synthase	15
Vitamin D and COVID‐19—Revisited	15
Respiratory and systemic monocytes, dendritic cells, and myeloid‐derived suppressor cells in COVID‐19: Implications for disease severity	15
DNA‐editing enzymes as potential treatments for heteroplasmic mtDNA diseases	15
Evaluation of SARS‐CoV‐2 antibody levels on hospital admission as a correlate of protection against mortality	15
BMI is positively associated with accelerated epigenetic aging in twin pairs discordant for body mass index	14
Fat mass and fat‐free mass in relation to cardiometabolic diseases: a two‐sample Mendelian randomization study	14
Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one‐year randomized controlled trial	14
Reduction of protein‐bound uraemic toxins in plasma of chronic renal failure patients: A systematic review	14
Nonalcoholic fatty liver disease is associated with a decreased myocardial mechano‐energetic efficiency	14
Primary aldosteronism: Higher volume load, cardiac output and arterial stiffness than in essential hypertension	14
Treating hypothyroidism is not always easy: When to treat subclinical hypothyroidism, TSH goals in the elderly, and alternatives to levothyroxine monotherapy	14
Neuroimaging phenotypes of CSF1R‐related leukoencephalopathy: Systematic review, meta‐analysis, and imaging recommendations	14
Growth hormone deficiency in adults with hypopituitarism—What are the risks and can they be eliminated by therapy?	14
Low antispike antibody levels correlate with poor outcomes in COVID‐19 breakthrough hospitalizations	14
Calcitonin gene‐related peptide (CGRP) is a key molecule released in acute migraine attacks—Successful translation of basic science to clinical practice	14
Osteoarthritis, part of life or a curable disease? A bird's‐eye view	14
Tuberculosis in patients with systemic lupus erythematosus–a 37‐year longitudinal survey‐based study	14
Effectiveness of REGEN‐COV antibody cocktail against the B.1.617.2 (delta) variant of SARS‐CoV‐2: A cohort study	14
Tenosynovial complications identify TTR cardiac amyloidosis among patients with hypertrophic cardiomyopathy phenotype	13
Does diet influence aging? Evidence from animal studies	13
Antimicrobial therapy during cancer treatment: Beyond antibacterial effects	13
Clinical characteristics and predictors of the duration of SARS‐CoV‐2 viral shedding in 140 healthcare workers	13
Estimated salt intake and risk of atrial fibrillation in a prospective community‐based cohort	13
Shared decision‐making interventions: An overview and a meta‐analysis of their impact on vaccine uptake	13
Use of oral anticoagulants after ischaemic stroke in patients with atrial fibrillation and cancer	12
Cerebrotendinous xanthomatosis without neurological involvement	12
Lung perfusion disturbances in nonhospitalized post‐COVID with dyspnea—A magnetic resonance imaging feasibility study	12
Optimal management of severe symptomatic gastroesophageal reflux disease	12
Diagnostic performance of 18F‐FDG‐PET/CT in inflammation of unknown origin: A clinical series of 317 patients	12
Risk factors for anti‐drug antibody formation to infliximab: Secondary analyses of a randomised controlled trial	12
Carving out a place for internal medicine during COVID‐19 epidemic in Italy	12
Abdominal aortic aneurysms: pathophysiology and clinical issues	12
Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes	12
Tobacco smoking confers risk for severe COVID‐19 unexplainable by pulmonary imaging	12
Eligibility for sacubitril/valsartan in heart failure across the ejection fraction spectrum: real‐world data from the Swedish Heart Failure Registry	11
Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases	11
2D shear wave elastography combined with age and serum biomarkers prior to kasai surgery predicts native liver survival of biliary atresia infants	11
Real‐world evidence for the effectiveness of vitamin D supplementation in reduction of total and cause‐specific mortality	11
Application of precision medicine in clinical routine in haematology—Challenges and opportunities	11
Genome‐wide search for genes affecting the age at diagnosis of type 1 diabetes	11
Joint impact of common risk factors on incident dementia: A cohort study of the Swedish Twin Registry	11
Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke	11
The association between bacterial infections and the risk of coronary heart disease in type 1 diabetes	11
Predictive models for clinical decision making: Deep dives in practical machine learning	11
Renal function in patients with significant tricuspid regurgitation: pathophysiological mechanisms and prognostic implications	11
The impact of a tailored mindfulness‐based program for resident physicians on distress and the quality of care: A randomised controlled trial	11
Is mapping the BCG vaccine‐induced immune responses the key to improving the efficacy against tuberculosis?	11
Chronic rhinosinusitis is associated with prolonged SARS‐CoV‐2 RNA shedding in upper respiratory tract samples: A case‐control study	11
Tocilizumab in COVID‐19 interstitial pneumonia	11
Randomized clinical trial of BCG vaccine in patients with convalescent COVID‐19: Clinical evolution, adverse events, and humoral immune response	11
The role of extracellular histones in COVID‐19	11
RNAi therapy with givosiran significantly reduces attack rates in acute intermittent porphyria	11
Obesity in adolescent men increases the risk of venous thromboembolism in adult life	11
The role of clonal haematopoiesis in cardiovascular diseases: epidemiology and experimental studies	10
Classic heat stroke in a desert climate: A systematic review of 2632 cases	10
Coeliac disease and noncoeliac wheat or gluten sensitivity	10
Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification	10
Hyperglycaemia‐associated Caspase‐3 predicts diabetes and coronary artery disease events	10
Post‐acute cognitive and mental health outcomes amongst COVID‐19 survivors: early findings and a call for further investigation	10
Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients	10
Microbiota restoration for recurrent Clostridioides difficile: Getting one step closer every day!	10
The development of preprints during the COVID‐19 pandemic	10
Hypertensive nephrosclerosis: wider kidney biopsy indications may be needed to improve diagnostics	10
Myocardial infarction in diffuse large B‐cell lymphoma patients – a population‐based matched cohort study	10
Neutrophil count predicts clinical outcome in hospitalized COVID‐19 patients: Results from the NOR‐Solidarity trial	10