Platelets

Article	Citations
Immunothrombosis and thromboinflammation in host defense and disease	93
A proof of evidence supporting abnormal immunothrombosis in severe COVID-19: naked megakaryocyte nuclei increase in the bone marrow and lungs of critically ill patients	52
Platelet Rich Plasma in Orthopedic Surgical Medicine.	50
Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicine	40
PRP in wound healing applications	40
Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity	38
Platelet rich plasma in oral and maxillofacial surgery from the perspective of composition	34
The thrombopoietin receptor: revisiting the master regulator of platelet production	32
Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases	32
Search for SARS-CoV-2 RNA in platelets from COVID-19 patients	30
Cerebral venous sinus thrombosis associated with spontaneous heparin-induced thrombocytopenia syndrome after total knee arthroplasty	30
Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure	28
Neonatal platelet physiology and implications for transfusion	25
Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib	25
Rotational thromboelastometry (ROTEM) profiling of COVID–19 patients	25
Efficacy and safety evaluation of avatrombopag in immune thrombocytopenia: analyses of a phase III study and long-term extension	24
Platelet-rich plasma promotes bone formation, restrains adipogenesis and accelerates vascularization to relieve steroids-induced osteonecrosis of the femoral head	24
Isolation of murine bone marrow by centrifugation or flushing for the analysis of hematopoietic cells – a comparative study	23
Risk of major adverse cardiovascular events of CYP2C19 loss-of-function genotype guided prasugrel/ticagrelor vs clopidogrel therapy for acute coronary syndrome patients undergoing percutaneous	22
Platelets and viruses	21
Application of Platelet Rich Fibrin in Tissue Engineering: Focus on Bone Regeneration	21
The structure of CLEC-2: mechanisms of dimerization and higher-order clustering	20
Human platelet lysates for human cell propagation	18
Early recognition of sepsis-induced coagulopathy using the C2PAC index: a ratio of soluble type C lectin-like receptor 2 (sCLEC-2) level and platelet count	18
Extensive characterization of the composition and functional activities of five preparations of human platelet lysates for dedicated clinical uses	18

Bioinspired artificial platelets: past, present and future	17
Platelets and renal failure in the SARS-CoV-2 syndrome	17
Platelet–leukocyte interactions in the pathogenesis of viral infections	17
Immobilized collagen prevents shedding and induces sustained GPVI clustering and signaling in platelets	16
The role of miRNAs in regulation of platelet activity and related diseases - a bioinformatic analysis	16
Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?	15
Platelets in dengue infection: more than a numbers game	15
Cytosolic and mitochondrial Ca2+ signaling in procoagulant platelets	14
EDTA stabilizes the concentration of platelet-derived extracellular vesicles during blood collection and handling	14
The efficacy and safety of thrombopoietin receptor agonists in patients with chronic liver disease undergoing elective procedures: a systematic review and meta-analysis	14
Alterations in platelets during SARS-CoV-2 infection	14
Thrombosis in Covid-19 and non-Covid-19 pneumonia: role of platelets	13
Prevalence and natural history of variants in the ANKRD26 gene: a short review and update of reported cases	13
Platelet reticulated forms, size indexes and functional activity. Interactions in healthy volunteers.	13
Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function	13
Zinc: an endogenous and exogenous regulator of platelet function during hemostasis and thrombosis	13
Release of α-granule contents during platelet activation	13
Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B	13
Frozen and cold-stored platelets: reconsidered platelet products	13
Efficacy and safety of eltrombopag in Chinese patients with chronic immune thrombocytopenia: stage 2 results from a multicenter phase III study	12
Platelet count and function in umbilical cord blood versus peripheral blood in term neonates	12
Platelet Function Assays for the Diagnosis of Aspirin Resistance	12
Severe thrombocytopenia in adults undergoing extracorporeal membrane oxygenation is predictive of thrombosis	12
Diagnostic and prognostic role of platelets in patients with sepsis and septic shock	12
Left ventricular assist device implantation causes platelet dysfunction and proinflammatory platelet-neutrophil interaction	12
Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2	11
Platelet-derived microparticles stimulated by anti-β 2 GPI/β 2 GPI complexes induce pyroptosis of endothelial cells in antiphospho	11
Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors	11
Antiplatelet drugs and liver fibrosis	11
In vitro evaluation of platelet extracellular vesicles (PEVs) for corneal endothelial regeneration	11
Differential effect of clopidogrel and ticagrelor on leukocyte count in relation to patient characteristics, biomarkers and genotype: a PLATO substudy	10
New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans	10
Apoptosis is one cause of thrombocytopenia in patients with high-altitude polycythemia	10
Sex differences in antiplatelet therapy: state-of-the art	10
P2X1: a unique platelet receptor with a key role in thromboinflammation	10
Thrombocytopenia and platelet count recovery in patients with sepsis-3: a retrospective observational study	10
GPIb-IX-V and platelet clearance	10
Injectable platelet-rich fibrin positively regulates osteogenic differentiation of stem cells from implant hole via the ERK1/2 pathway	10
Signaling mechanisms of the platelet glycoprotein Ib-IX complex	9
A proprietary GMP human platelet lysate for the expansion of dermal fibroblasts for clinical applications	9
Selective inhibition of thromboinflammation in COVID-19 by Btk inhibitors	9
High extracellular phosphate increases platelet polyphosphate content	9
Effect of differently coated silver nanoparticles on hemostasis	9
High-efficiency unassisted transfection of platelets with naked double-stranded miRNAs modulates signal-activated translation and platelet function	9
Investigation of fibrinogen in early bleeding of patients with newly diagnosed acute promyelocytic leukemia	9
The enigmatic nature of the triggering receptor expressed in myeloid cells -1 (TLT- 1)	9
Platelets enhance CD4+ central memory T cell responses via platelet factor 4-dependent mitochondrial biogenesis and cell proliferation	9
Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis	9
Distribution and quantification of activated platelets in platelet-rich fibrin matrices	9
Immature platelet indices alongside procalcitonin for sensitive and specific identification of bacteremia in the intensive care unit	9

Distinct phenotypes of platelet, monocyte, and neutrophil activation occur during the acute and convalescent phase of COVID-19	9
Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants	8
Evolution of platelet activation parameters during septic shock in intensive care unit	8
Platelet-derived mitochondria transfer facilitates wound-closure by modulating ROS levels in dermal fibroblasts	8
Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology	8
Association of lipoprotein(a) with platelet aggregation and thrombogenicity in patients undergoing percutaneous coronary intervention	8
Management of immune thrombotic thrombocytopenic purpura with caplacizumab: a Canadian, single-centre, real-world experience	8
Structural analysis of resting mouse platelets by 3D-EM reveals an unexpected variation in α-granule shape	8
Whole blood flow cytometry protocol for the assessment of platelet phenotype, function, and cellular interactions	8
Platelet-derived respiratory-competent mitochondria transfer to mesenchymal stem cells to promote wound healing via metabolic reprogramming	8
Optimized tool for evaluation of platelet function measured by impedance aggregometry	8
New presentations and exacerbations of immune thrombocytopenia after coronavirus disease 2019 vaccinations: the Taiwan experience	7
Reply to “Peripheral versus central venous blood sampling does not influence the assessment of platelet activation in cirrhosis”	7
Characteristics of L-PRP preparations for treating Achilles tendon rupture within the PATH-2 study	7
Human Platelets and Influenza Virus: Internalization and Platelet Activation	7
Enrichment of plasma in platelets and extracellular vesicles by the counterflow to erythrocyte settling	7
Refractory immune thrombocytopenia successfully treated with bortezomib in a child with 22q11.2 deletion syndrome, complicated by Evans syndrome and hypogammaglobulinemia	7
The potency of selatogrel, a reversible antagonist of the P2Y12 receptor, is affected by calcium concentration	7
Pathogen inactivation of platelets for transfusion	7
Helicobacter pylori protein that binds to and activates platelet specifically reacts with sera of H. pylori-associated chronic immune thrombocytopenia	7
Novel antiplatelet strategies targeting VWF and GPIb	7
Platelets: bridging thrombosis and inflammation	7
Relationship between Hepatitis B virus infection and platelet production and dysfunction	7
Prognostic significance of thrombocytosis in lung cancer: a systematic review and meta-analysis	7
Association between platelet counts and morbidity and mortality after endovascular repair for type B aortic dissection	7
Recovery of platelet reactivity following cessation of either aspirin or ticagrelor in patients treated with dual antiplatelet therapy following percutaneous coronary intervention: a GLOBAL LEADERS su	7
Why do platelets express K+ channels?	7
Statins potentiate the antibacterial effect of platelets on Staphylococcus aureus	7
Platelet activation and aggregation in different centrifugal-flow left ventricular assist devices	7
Whole blood platelet aggregation measurement by Multiplate™: potential diagnostic inaccuracy of correcting the results for the sample platelet count	7
Eltrombopag modulates the phenotypic evolution and potential immunomodulatory roles of monocytes/macrophages in immune thrombocytopenia	6
Exacerbation of immune thrombocytopenia following initial and booster vaccination with Pfizer-BioNTech COVID-19 vaccine	6
Complement activation negatively affects the platelet response to thrombopoietin receptor agonists in patients with immune thrombocytopenia: a prospective cohort study	6
Mean platelet volume: a prognostic marker in heart failure with preserved ejection fraction	6
Comparison of antiplatelet antibody profiles between hepatitis C virus-associated immune thrombocytopenia and primary immune thrombocytopenia	6
Comparison of the effects of platelet concentrates produced by high and low-speed centrifugation protocols on the healing of critical-size defects in rat calvaria: a microtomographic and histomorphome	6
Is the endogenous ligand for PEAR1 a proteoglycan: clues from the sea	6
“Tailored” antiplatelet bridging therapy with cangrelor: moving toward personalized medicine	6
Circulating microRNAs as biomarkers and mediators of platelet activation	6
Platelet-leukocyte aggregate formation and inflammation in patients with pulmonary arterial hypertension and CTEPH	6
Hemostasis-on-a-chip / incorporating the endothelium in microfluidic models of bleeding	6
Irradiation of platelets in transfusion medicine: risk and benefit judgments	6
Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas	6
Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: preparation and in vitro characterization	6
Innate immune TLR7 signaling mediates platelet activation and platelet-leukocyte aggregate formation in murine bacterial sepsis	6
The efficacy of platelet rich plasma on anterior cruciate ligament reconstruction: a systematic review and meta-analysis	6
Effect of avatrombopag in the management of severe and refractory chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors	6
The role of viscoelastic testing in assessing peri-interventional platelet function and coagulation	6
Flow cytometry identifies an early stage of platelet apoptosis produced by agonists of the P2X1 and P2X7 receptors	6
Ionotropic glutamate receptors in platelets: opposing effects and a unifying hypothesis	6
Peripheral versus central venous blood sampling does not influence the assessment of platelet activation in cirrhosis	5
Successful mRNA SARS-Cov-2 vaccine rechallenge after a first episode of immune thrombocytopenic purpura	5
First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants	5
Current challenges in platelet transfusion	5
Platelet count and disease – editorial policy	5
Developmental differences of in vitro cultured murine bone marrow- and fetal liver-derived megakaryocytes	5
Profile of reticulated platelets in the early, subacute and late phases after transient ischemic attack or ischemic stroke	5
Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength	5
Efficacy of platelet transfusion in cardiac surgery	5
A platelet lipidomics signature in patients with COVID-19	5
Effects of leukocyte-rich platelet-rich plasma and leukocyte-poor platelet-rich plasma on the healing of bone-tendon interface of rotator cuff in a mice model	5
Catastrophic antiphospholipid syndrome refractory to high-dose intravenous immunoglobulin responsive to therapeutic plasma exchange	5
Method article: anin vitroblood flow model to advance the study of platelet adhesion utilizing a damaged endothelium	5
Avatrombopag improves thrombocytopenia in MYH9-related disorder following eltrombopag treatment failure	5
Pro-apoptotic properties and mitochondrial functionality in platelet-like-particles generated from low Aspirin-incubated Meg-01 cells	5
Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients	5
Platelet glycogenolysis is important for energy production and function	5
Fatal cerebral hemorrhage in a patient with thrombotic thrombocytopenic purpura with a normal platelet count during treatment with caplacizumab	5
The effect of platelet-rich plasma injection on chronic Achilles tendinopathy and acute Achilles tendon rupture	5
Potential biomarkers for inherited thrombocytopenia 2 identified by plasma proteomics	4
Romiplostim for PARP inhibitor-induced thrombocytopenia in solid tumor malignancies	4
Aquaporins in platelet function	4
Pre-operative platelet reactivity is a strong, independent predictor of bleeding complications after branched endovascular thoracoabdominal aortic aneurysm repair	4
ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock	4
The utility of platelet activation biomarkers in thrombotic microangiopathies	4
Effect of iron supplementation on platelet count in adult patients with iron deficiency anemia	4
Does hsa-miR-223-3p from platelet-derived extracellular vesicles regulate tissue factor expression in monocytic cells?	4
Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area)	4
Treatment of immune thrombocytopenia (ITP) secondary to malignancy: a systematic review	4
Effects of platelet-rich fibrin produced by three centrifugation protocols on bone neoformation in defects created in rat calvaria	4

Effects of remote ischemic preconditioning on platelet activation and reactivity in patients undergoing cardiac surgery using cardiopulmonary bypass: a randomized controlled trial	4
Mind the gap: connexins and pannexins in platelet function	4
Recombinant human thrombopoietin (rhTPO) of different dosing regimens for refractory/relapsed primary immune thrombocytopenia: a multicenter, randomized controlled trial and pharmacokinetics study	4
Acquired platelet defect associated with gabapentin treatment: a case-report	4
Effects of electret coating technology on coronary stent thrombogenicity	4
Contributing role of mitochondrial energy metabolism on platelet adhesion, activation and thrombus formation under blood flow conditions	4
High fragmentation in platelet concentrates impacts the activation, procoagulant, and aggregatory capacity of platelets	4
Platelet parameters and risk of hypertension disorders of pregnancy: a propensity score adjusted analysis	4
Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy	4
Risk stratification and outcomes of intracranial hemorrhage in patients with immune thrombocytopenia under 60 years of age	4
Combining human platelet proteomes and transcriptomes: possibilities and challenges	4
Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis	4
Platelets after burn injury – hemostasis and beyond	4
A novel RUNX1 exon 3 - 7 deletion causing a familial platelet disorder	4
Platelet surface GPIbα, activated GPIIb-IIIa, and P-selectin levels in adult veno-arterial extracorporeal membrane oxygenation patients	4
The Total Thrombus Formation (T-TAS) platelet (PL) assay, a novel test that evaluates whole blood platelet thrombus formation under physiological conditions	4
Intravenous abciximab as a rescue therapy for immediate reocclusion after successful mechanical thrombectomy in acute ischemic stroke patients	4
Immature platelets in COVID-19	4
Rapid isolation of mature murine primary megakaryocytes by size exclusion via filtration	4
Efficacy and safety of short-term 1–3 months versus standard 12 months dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a meta-analysis of randomized clinical trial	3
Whole blood dynamic platelet aggregation counting and 1-year clinical outcomes in patients with coronary heart diseases treated with clopidogrel	3
Efficacy and safety of abciximab versus tirofiban in addition to ticagrelor in STEMI patients undergoing primary percutaneous intervention	3
TSST-1 protein exerts indirect effect on platelet activation and apoptosis	3
The state of the art and future of PRP therapy	3
The utility of flow cytometric platelet forward scatter as an alternative to mean platelet volume	3
Pathogenic mechanisms contributing to thrombocytopenia in patients with systemic lupus erythematosus	3
Severe thrombocytopenia and intracranial hemorrhage in a newborn with Noonan syndrome and neonatal alloimmune thrombocytopenia	3
F11R/JAM-A: why do platelets express a molecule which is also present in tight junctions?	3
An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay	3
Thrombocytopathy vs Platelet hyper-reactivity in COVID-19: diverse pathologies, disease outcomes and therapeutic implications	3
Thrombus remodelling by reversible and irreversible P2Y 12 inhibitors	3
Effects of platelets activated by different agonists on fibrin formation and thrombin generation	3
Healthy pediatric platelets are moderately hyporeactive in comparison with adults’ platelets	3
GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction	3
Cold stored platelets in the management of bleeding: is it about bioenergetics?	3
Absence of bleeding upon dual antiplatelet therapy in a patient with a immune GPVI deficiency	3
Determination of fibrin clot growth and spatial thrombin propagation in the presence of different types of phospholipid surfaces	3
What can we learn from senescent platelets, their transcriptomes and proteomes?	3
Correlation of CLEC1B haplotypes with plasma levels of soluble CLEC-2 in healthy individuals	3
The effect of short-term cryopreservation on the properties and functionality of platelet-rich plasma	3
Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP	3
Additional efficacy analysis of avatrombopag phase III data for the treatment of adults with immune thrombocytopenia	3
Significance of mild thrombocytopenia in maintenance hemodialysis patients; a retrospective cohort study	3
Evaluating stored platelet shape change using imaging flow cytometry	3
Evening aspirin intake results in higher levels of platelet inhibition and a reduction in reticulated platelets - a window of opportunity for patients with cardiovascular disease?	3
Immature platelets and cardiovascular events in patients with stable coronary artery disease	3
Successful treatment of acquired amegakaryocytic thrombocytopenia with eltrombopag and immunosuppressant	3
The plant hormone abscisic acid stimulates megakaryocyte differentiation from human iPSCs in vitro	3
Mass cytometry of platelet-rich plasma: a new approach to analyze platelet surface expression and reactivity	3
How can we use proteomics to learn more about platelets?	3
A novel frameshiftGP1BBmutation causes autosomal dominant macrothrombocytopenia with decreased vWF receptor expression but normal platelet aggregation	3
New αIIbβ3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains	3
Not-high before-treatment platelet reactivity in patients with STEMI: prevalence, clinical characteristics, response to therapy and outcomes	3
Hiding in plain sight – platelets, the silent carriers of HIV-1	3
Reversible cross-tolerance to platelet-activating factor signaling by bacterial toxins	3
Actin polymerization regulates glycoprotein Ibα shedding	3
EDI(torial): equality, diversity, and inclusion and platelets - 2021	3
α-Synuclein is the major platelet isoform but is dispensable for activation, secretion, and thrombosis	3
Feasibility of a mean platelet volume standard: an international council for standardization in hematology (ICSH) inter-laboratory study	3
Building platelet phenotypes: Diaphanous-related formin 1 (DIAPH1)-related disorder	3
What can we learn from the platelet lipidome?	3
High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on αIIbβ3 and platelet secretion	3
Evaluation of human platelet granules by structured illumination laser fluorescence microscopy	3
Clopidogrel versus ticagrelor in East Asian patients aged 75 years or older with acute coronary syndrome: observations from the GF-APT registry	3