Current Opinion in Immunology

Article	Citations
Gene: environment interactions in immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 infection	443
Oncogenic viruses, cancer biology, and innate immunity	111
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation	110
An easy pill to swallow: oral recombinant vaccines for the 21st century	98
T cells in Sjögren’s disease: update on their role in salivary gland pathogenesis and treatment	84
The future of vaccination in Latin America: learning from the COVID-19 pandemic	74
Can we cure primary biliary cholangitis?	64
Principles and practical applications of structure-based vaccine design	63
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity	59
TAP-ing into the cross-presentation secrets of dendritic cells	59
Mechanistic insights into epigenetic contributions to psoriasis pathogenesis and their clinical implications	59
Can juvenile idiopathic arthritis be cured?	59
Complement in antiphospholipid syndrome, time to target?	56
Nutritional modulation of antitumor immunity	55
Metabolism and macrophages in the tumor microenvironment	55
Neuropsychiatric lupus: a myriad of symptoms requires a myriad of models	52
Can sarcoidosis be cured?	48
The epidermal immune microenvironment plays a central role in the pathogenesis of psoriasis	46
Pharmacotherapeutic strategies to promote regulatory T cell function in autoimmunity	40
Beyond the gastric epithelium — the paradox of Helicobacter pylori-induced immune responses	37
Commander-in-chief: monocytes rally the troops for defense against aspergillosis	34
Can we cure Behçet syndrome?	32
B cell–targeted therapies in autoimmune skin disease: current advances and challenges	32
Innate antiviral immunity and immunometabolism in hepatocytes	31
Necroptosis in immunity, tissue homeostasis, and cancer	31

Regulation of MHC class II and CD86 expression by March-I in immunity and disease	31
Some thoughts about what non-mammalian jawed vertebrates are telling us about antigen processing and peptide loading of MHC molecules	30
Mapping and modelling human B cell maturation in the germinal centre	29
A critical look at observational studies	29
Immunological scars after cure of hepatitis C virus infection: Long‐HepC?	28
Implication of epigenetic factors in development and recurrence of psoriasis	28
Animal models of autoimmune encephalitis	27
Editorial Board	27
Bioinspired vaccines to enhance MHC class-I antigen cross-presentation	27
The power of genetics in decoding Sjögren’s disease: current status and future development	27
Patterns of bacterial viability governing noncanonical inflammasome activation	27
Can we cure bullous skin diseases?	26
Mechanistic considerations linking SARS-CoV-2 infection, inflammation, and the loss of immune tolerance	26
Game of Omes: ribosome profiling expands the MHC-I immunopeptidome	25
Editorial Board	25
Resolving adjuvant mode of action to enhance vaccine efficacy	24
Can we cure antiphospholipid syndrome?	24
Harnessing IgG Fc glycosylation for clinical benefit	23
Outer membrane vesicle-based intranasal vaccines	22
Use of synthetic data, a novel paradigm for immunopathology	22
Thetis cells: regulators of intestinal immune tolerance	21
Nucleic acid triggers of autoimmunity and autoinflammation	21
Immune responses to Toxoplasma gondii	21
The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention	21
Editorial Board	20
Killing in self-defense: proapoptotic drugs to eliminate intracellular pathogens	20
HLA-B27 as a potential target for the cure of axial spondyloarthritis	20
Editorial Board	20
A throwback on 25 years in pannexin research	20
Powerful microscopy technologies decode spatially organized cellular networks that drive response to immunotherapy in humans	20
Rheumatoid arthritis — the role of T cells in this complex systemic autoimmune disease	19
New autoantibodies in Sjögren's disease	19
Inborn errors of human transcription factors governing IFN-γ antimycobacterial immunity	19
Treating sarcoidosis: when less is more	19
Intracellular complement in monocytes and macrophages: emerging roles	18
New insights into the mechanisms regulating plasma cell survival and longevity	18
B cell memory of Immunoglobulin E (IgE) antibody responses in allergy	18
Epigenetics: the link between environmental exposures and autoimmune diseases	18
Neuroimmune crosstalk in the skin: a delicate balance governing inflammatory processes	18
Can we cure lupus?	17
A critical look at animal and cellular models in autoinflammatory diseases	17
Clinical trials and new therapies in Sjögren’s disease	17
Metabolomic signaling in sarcoidosis pathogenesis	17
Won’t you be my neighbor? Control of the immune response by stromal and immune cell microenvironments within the lymph node	17
Mechanisms and risk factors for perinatal allergic disease	16
Immune dyshomeostasis in lifestyle-associated diseases: a new paradigm for personalized medicine and prevention	16
Multiple sclerosis: a disease or a syndrome?	16
Drivers and shapers of macrophages specification in the developing brain	16
Regulation of type I and type III interferon induction in response to pathogen sensing	16
Targeting synovial fibroblast KCa1.1 channels in rheumatoid arthritis	16

Challenges in diagnosis of sarcoidosis	15
Immunometabolic regulation of germinal centers and its implications for aging	15
‘Can we cure IgG4-related diseases?’	15
IFNε, IFNω and IFNλ: interferons defending the mucosa	15
Regulation of inflammation by Interleukin-10 in the intestinal and respiratory mucosa	15
TH17 cell immune adaptation	15
Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment	15
Eliciting or silencing complement activation: strategies for optimizing monoclonal antibodies functions	15
Defining the niche for stem-like CD8+ T cell formation and function	15
The role of epigenetics in inflammatory memory	15
Tumor immune evasion through loss of MHC class-I antigen presentation	15
Red blood cell alloimmunization immunogenetic risk factor	15
Major histocompatibility complex class II in the tumor microenvironment: functions of nonprofessional antigen-presenting cells	14
PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis	14
Why we need to maintain a critical view on big data and artificial intelligence predictions	14
New insights and approaches for analyses of immunopeptidomes	14
Advances and challenges in investigating B-cells via single-cell transcriptomics	14
Composite and pragmatic measures in psoriatic arthritis: bridging trials and clinical feasibility	14
The role of epigenetic modifications in systemic autoinflammatory diseases	14
Autoimmunity, epitope analysis, and molecular mimicry	14
HyperIgE in hypomorphic recombination-activating gene defects	13
Differential signaling by type-I and type-III interferons in mucosa	13
Layers of defense: protection from respiratory viruses by epithelial-intrinsic immunity	13
The choroid plexus in inflammatory and degenerative diseases of the central nervous system	13
Functional flexibility and plasticity in immune control of systemic Salmonella infection	13
The thymoproteasome in shaping the CD8+ T-cell repertoire	13
Addressing unmet needs in rheumatoid arthritis: the challenge of translating multi-omics into precision therapies	12
Editorial overview: Tumour immunology: Engineered T cell therapy of cancer: current success and future improvements	12
Curing inflammatory bowel diseases: breaking the barriers of current therapies– emerging strategies for a definitive treatment	12
Inherited human ZNF341 deficiency	12
Editorial overview: Special section neuroimmunology: Neuroimmune interactions in health and disease	11
Mpox virus immunology: exploring links to autoimmune diseases	11
Molecular insights into metabolite antigen recognition by mucosal-associated invariant T cells	11
Human inborn errors of type I interferon–independent intrinsic immunity in nonleukocytic cells	11
Microbiota and B-1 B cell repertoire development in mice	11
Editorial Board	11
Local complement inhibition by selective precision-targeted therapies	11
The role of intestinal bacteria in promoting tolerance to food	11
Microevolution of Pseudomonas aeruginosa in the airways of people with cystic fibrosis	10
The role of different aPL subpopulations in the lupus anticoagulant phenomenon	10
Pulmonary transfusion reactions as an immunological spectrum disorder	10
Potential immune consequences of cold-stored platelet transfusion	10
A liver–mitochondria–immune axis in Parkinson’s disease: emerging perspectives on a hepatic origin for mitochondrial autoimmunity as a driver of Parkinson’s disease	10
T follicular helper cells in food allergy	10
Inflammasomes and their role in PANoptosomes	10
Spontaneous and induced adaptive immune responses in Alzheimer’s disease: new insights into old observations	10
B-cell antigen presentation in central nervous system autoimmunity	10
Harnessing dendritic cell diversity in cancer immunotherapy	10
Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases	10
Inflammation induced by lipid mediators and protein from transfusion products	10
The vicious cycle governing the brain–immune system relationship in neurodegenerative diseases	10
From metabolomics to transfusion-associated immunomodulation	10
Gut microbiota in pathogenesis and therapeutic potentials in rheumatoid arthritis	9
Spatiotemporal and cell-state control of antigen presentation during tolerance and immunity	9
Editorial overview: Getting the house in order: Cell-intrinsic mechanisms of innate immune defence	9
Can we cure Sjogren’s disease? Unmet needs and raising questions in the era of Precision medicine	9
From disease to syndrome: the evolution of Parkinson’s as a heterogeneous entity	9
Extracellular vesicle impact on immunity following blood transfusion	9
Multilevel approaches to immunization equity	9
Mapping the B-cell axis in Sjögren’s disease: repertoire, microenvironment, and potential routes to precision treatment	9
Immunosenescence and human healthspan. Lessons from centenarians	9
The tumor-driven antibody-mediated immune response in cancer	9
Editorial Board	9
The next frontier in vaccine design: blending immune correlates of protection into rational vaccine design	8
SARS-CoV-2 and chronic kidney disease: challenges and future directions	8
Neuroimmune mechanisms of neuropsychiatric systemic lupus erythematosus	8
The indole-brain connection: neuroimmune mechanisms and therapy	8
Autoimmune-related adverse events induced by immune checkpoint inhibitors	8
Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction	8
Immunotherapy for pemphigus and bullous pemphigoid	8
The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules	8
In search of the cell biology for self- versus non-self- recognition	8
The role of linked recognition and B cell precursor frequency in alloimmunization to transfused RBCs	8
Friends close, enemies closer: the complex role of the microbiome in antitumor immunity	8
Emerging novel therapies for steroid-refractory acute graft-versus-host disease: recent advances and future directions	8
Toward indole postbiotics precision therapy via AI-powered drug delivery technologies	8
Elderly-onset rheumatoid arthritis as a distinct entity: mechanisms, manifestations, and treatment	8
Editorial Board	8
From sensing to shaping: microglial responses in the pathogenesis of viral encephalitis	7
B cells spatial organization defines their phenotype and function in cancer “Tell me with whom you consort, and I will tell you who you are” ― Goethe	7

Advances in treatment of psoriatic arthritis: current guidelines and emerging therapies	7
Structure–function of type I and III interferons	7
T cell immunity to cytomegalovirus infection	7
TRPM7 channel-kinase in immunity: new frontiers of an emerging therapeutic target	7
Fuelling B cells: dynamic regulation of B cell metabolism	7
Antiviral responses in peripheral and brain neurons	7
A critical look at disease classification/diagnosis criteria in rheumatology	7
Moving beyond the Janus kinase signaling kinases in the pathogenesis and treatment of psoriasis and psoriatic arthritis	7
Major histocompatibility complex class I assembly within endolysosomal pathways	7
Peptide-dependent tuning of major histocompatibility complex motional properties and the consequences for cellular immunity	7
Carbohydrate metabolism in supporting and regulating neutrophil effector functions	6
Editorial Board	6
Optimizing patient-reported outcomes for sarcoidosis	6
Understanding antiphospholipid syndrome clinical phenotypes with the guidance of antiphospholipid antibody-related pathogenic mechanisms	6
Insights into the pathogenesis of allergic disease from dedicator of cytokinesis 8 deficiency	6
Chemokines that govern T cell activity in tumors	6
Insights into pandemic respiratory viruses: manipulation of the antiviral interferon response by SARS-CoV-2 and influenza A virus	6
Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells	6
The role of stromal cell immunobiology in understanding and managing Sjögren’s disease	6
Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite	6
Editorial Board	6
The role of interferon in the thymus	6
Immunological insights in the treatment of chronic hepatitis B	6
T-bethighCD21low B cells: the need to unify our understanding of a distinct B cell population in health and disease	6
Minor salivary gland biopsy in Sjogren’s disease: a diagnostic and prognostic tool toward precision medicine	6
Turning foes into permissive hosts: manipulation of macrophage polarization by intracellular bacteria	6
Patterns and trends in sarcoidosis: an epidemiological perspective	6
Developments in oral enterotoxigenic Escherichia coli vaccines	5
Metabolic adaptations of ILC2 and Th2 cells in type 2 immunity	5
Cell entry and innate sensing shape adaptive immune responses to adenovirus-based vaccines	5
Tipping the balance: innate and adaptive immunity in mitochondrial disease	5
Metabolic footprint and logic through the T cell life cycle	5
Lymphatic messengers: Non-antigen soluble mediators from diseased tissues to draining lymph nodes	5
Nr4a nuclear receptors: markers and modulators of antigen receptor signaling	5
Regulatory T cells in the context: deciphering the dynamic interplay with the tissue environment	5
T cell–B cell interactions in human autoimmune diseases	5
Editorial Board	5
From genes to granulomas: the genetic blueprint of sarcoidosis	5
Determinants of persistent Salmonella infections	5
Advances in genetic–immunological targeted therapies for psoriasis	5
Dupilumab-associated lymphoproliferative disorders: a comprehensive review on clinicohistopathologic features and underlying mechanisms	5
Move and countermove: the integrated stress response in picorna- and coronavirus-infected cells	5
The role of allergen-specific regulatory T cells in the control of allergic disease	5
Beyond ion flux: the potassium channel KV1.3 and its regulatory function in neutrophils	5
C1 inhibitor: from complement system to bradykinin angioedema	5
Epithelial-immune interactions govern type 2 immunity at barrier surfaces	5
Evolution and prospects for the definition of clinically useful endpoints in Sjögren disease	5
Imaging the T-cell receptor: new approaches, new insights	4
Principles of bacterial innate immunity against viruses	4
Salivary gland organoids and the future of modeling autoimmune epithelitis in Sjögren’s disease	4
Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes	4
Systems biology approaches to unravel lymphocyte subsets and function	4
Hot topics in the antiphospholipid syndrome	4
Nasal vaccines for pertussis	4
Mapping economic outcomes: how biosimilars enhance access to health systems in Latin America and the Caribbean	4
Insights into platelet post-transfusional human leukocyte antigen I immunization	4
Immunological complications of blood transfusion: current insights and advances	4
Messenger ribonucleic acid vaccines against infectious diseases: current concepts and future prospects	4
Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection	4
Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty	4
Editorial overview: Autoimmunity 2022	4
Neuroimmune recognition of allergens	4
Editorial overview: Innate immunity – 2023: Just in time defense	4
CD1 displays its own negative regulators	3
Evaluating the pandemic potential of Zika virus in a changing global landscape	3
COVID-19 and inflammatory bowel disease — what to know	3
Reinvigorating therapeutic cancer vaccines	3
Beyond skin deep: total-body positron emission tomography to illuminate systemic inflammation in psoriatic arthritis	3
Challenges and opportunities in the development of mucosal mRNA vaccines	3
Insights and perspectives into the discovery of complement-related biomarkers in cancer	3
‘Persistent germinal center responses: slow-growing trees bear the best fruits’	3
The antiviral state of the cell: lessons from SARS-CoV-2	3
Recent progress in understanding of allergic transfusion reaction	3
A global perspective on autoimmunity and immunodeficiency: exploring geoepidemiology trends	3
Tuberculosis as an unconventional interferonopathy	3
Recent progress in type 1 classical dendritic cell cross-presentation - cytosolic, vacuolar, or both?	3
Functional heterogeneity in the memory B-cell response	3
Complement system modulation in age-related macular degeneration: navigating failures, building future successes	3
Editorial Board	3
Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis	3
Beyond natural biology: rewiring cellular networks to study innate immunity	3
Pharma — manufacturing: the unappreciated and overlooked indispensable skill	3
Functional subsets of tumor-specific CD8+ T cells in draining lymph nodes and tumor microenvironment	3
Diet-derived microbial metabolites as regulators of immune function	3
Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function	3
Viral vector vaccines	3
Ubiquitination and cell-autonomous immunity	3
Primary sclerosing cholangitis: what is new in the therapeutic landscape	3
Primary atopic disorders: inborn errors of immunity causing severe allergic disease	3
A comprehensive study on the effect of alglucosidase alpha and immunomodulation on survival, motor and cardiac outcome, creatine kinase and antibody titers in classic infantile Pompe disease: the Monz	3
Regulation of host/pathogen interactions in the gastrointestinal tract by type I and III interferons	3
Bystander activation in memory and antigen-inexperienced memory-like CD8 T cells	3
Markers predicting lymphoma development in Sjögren disease: current status and future perspectives	3
Editorial Board	3
More X’s, more problems: how contributions from the X chromosomes enhance female predisposition for autoimmunity	3