Current Opinion in Immunology

Article	Citations
Recent advances in mRNA vaccine technology	289
COVID-19 vaccines	179
DNA vaccines: prime time is now	119
Type I interferon in the pathogenesis of systemic lupus erythematosus	100
The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease	91
Tryptophan and indole metabolism in immune regulation	81
Cross-presentation of exogenous antigens on MHC I molecules	76
Shaping humoral immunity to vaccines through antigen-displaying nanoparticles	74
Cancer-associated fibroblasts: key determinants of tumor immunity and immunotherapy	70
Food allergy: epidemiology, pathogenesis, diagnosis, prevention, and treatment	61
Vaccine hesitancy in migrant communities: a rapid review of latest evidence	59
Conserved strategies for pathogen evasion of cGAS–STING immunity	53
Mechanisms of non-type 2 asthma	52
Ebola virus disease: current vaccine solutions	50
Type I interferons and SARS-CoV-2: from cells to organisms	47
The politics of Covid-19 vaccine confidence	47
The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention	44
Metabolic control of B cell immune responses	44
Natural killers or ILC1s? That is the question	44
Innovations in structure-based antigen design and immune monitoring for next generation vaccines	43
A critical review of measures of childhood vaccine confidence	43
Cytokines and transcription factors in the differentiation of CD4+ T helper cell subsets and induction of tissue inflammation and autoimmunity	42
Detrimental activation of AhR pathway in cancer: an overview of therapeutic strategies	41
CBASS phage defense and evolution of antiviral nucleotide signaling	41
The role of CD4 T cells in rejection of solid tumors	41

The multifaceted functions of follicular regulatory T cells	41
Commensal bacteria in the upper respiratory tract regulate susceptibility to infection	40
HLA variation and antigen presentation in COVID-19 and SARS-CoV-2 infection	39
The high affinity IgE receptor: a signaling update	39
Innate lymphoid cells: from helper to killer	38
Sensing and clearance of apoptotic cells	37
Anti-interferon-γ autoantibody-associated immunodeficiency	37
Exploring cardiac macrophage heterogeneity in the healthy and diseased myocardium	37
The innate immune system and cell death in autoinflammatory and autoimmune disease	36
Tuning tuft cells: new ligands and effector functions reveal tissue-specific function	36
Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections	35
The host targeting effect of chloroquine in malaria	35
Inhibitory receptor agonists: the future of autoimmune disease therapeutics?	35
Recent advances in atopic dermatitis	35
Regulation of host physiology and immunity by microbial indole-3-aldehyde	33
New insights into B cells as antigen presenting cells	32
Protective and pathogenic roles for mast cells during viral infections	32
New horizons in adjuvants for vaccine development	32
Inborn errors of STAT1 immunity	31
Selection in the germinal center	30
Signals governing monocyte differentiation during inflammation	30
MHC I assembly and peptide editing — chaperones, clients, and molecular plasticity in immunity	29
Trained immunity: implications for vaccination	29
IgM memory B cells: specific effectors of innate-like and adaptive responses	27
Integrating resident memory into T cell differentiation models	27
Gut microbiome-mediated regulation of neuroinflammation	27
Viral vector vaccines	27
Intrinsic and extrinsic regulation of IgE B cell responses	27
Tryptophan metabolism in brain tumors — IDO and beyond	26
New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression	26
DRiPs get molecular	26
Interventions for vaccine hesitancy	26
Diversity and function of brain-associated macrophages	26
Supply and delivery of vaccines for global health	25
Improving efficacy of glycoconjugate vaccines: from chemical conjugates to next generation constructs	25
There is no gene for CVID — novel monogenetic causes for primary antibody deficiency	25
Mast cell tryptases in allergic inflammation and immediate hypersensitivity	25
Inborn errors of IL-6 family cytokine responses	24
Charcot–Leyden crystals and other protein crystals driving type 2 immunity and allergy	24
Adverse events induced by immune checkpoint inhibitors	24
Emerging roles of circular RNAs in innate immunity	23
Role of the NF-κB system in context-specific tuning of the inflammatory gene response	23
Major histocompatibility complex (MHC) class I and class II proteins: impact of polymorphism on antigen presentation	23
Leishmania Viannia guyanensis, LRV1 virus and extracellular vesicles: a dangerous trio influencing the faith of immune response during muco-cutaneous leishmaniasis	23
The epigenetically-encoded memory of the innate immune system	23
Innate immune defenses at the maternal-fetal interface	23
Biologic treatment options for severe asthma	23
Regulation of innate immunity by Nrf2	23
Mechanisms for control of skin immune function by the microbiome	22
Mycobacterial diseases in patients with inborn errors of immunity	22

Inflammasome activation and evasion by bacterial pathogens	21
Emerging technologies for systems vaccinology — multi-omics integration and single-cell (epi)genomic profiling	21
Epigenetics of T cell fate decision	20
TACI deficiency — a complex system out of balance	20
The role of enteric glia in intestinal immunity	19
Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling	19
HBV as a target for CAR or TCR-T cell therapy	19
Resistance mechanisms to checkpoint inhibitors	19
New function of zebrafish regulatory T cells in organ regeneration	19
CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics	18
Structural and dynamic studies of TAPBPR and Tapasin reveal the mechanism of peptide loading of MHC-I molecules	18
Down syndrome and type I interferon: not so simple	18
Immunity to EBV as revealed by immunedeficiencies	18
Virus-encoded cytokine and chemokine decoy receptors	17
Reflection: burden of cervical cancer in Sub-Saharan Africa and progress with HPV vaccination	17
The fibroblastic T cell niche in lymphoid tissues	17
The double life of serotonin metabolites: in the mood for joining neuronal and immune systems	17
New insights into human immunity from ancient genomics	17
BAFF signaling in health and disease	17
Dendritic cells and the skin environment	17
Mechanisms of response and resistance to CAR T cell therapies	17
Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces	16
Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection	16
Principles and practical applications of structure-based vaccine design	16
Cross-reactivity between microbial and tumor antigens	16
Emerging dimensions of cellular cGAS-STING signaling	15
Dynamics of MHC-I molecules in the antigen processing and presentation pathway	15
Autoimmunity, IgE and FcεRI-bearing cells	15
Infection and cancer suppress pDC derived IFN-I	15
Adoptive T cell therapy of solid tumors: time to team up with immunogenic chemo/radiotherapy	15
Epigenetic adjuvants: durable reprogramming of the innate immune system with adjuvants	15
Immune checkpoint receptors in autoimmunity	15
To TAP or not to TAP: alternative peptides for immunotherapy of cancer	15
The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease	15
Innate immune sensing by epithelial barriers	15
T cell immunity to cytomegalovirus infection	15
Vaping and e-cigarette use. Mysterious lung manifestations and an epidemic	15
Control of regulatory T cell homeostasis	14
Manipulating antigen presentation for antigen-specific immunotherapy of autoimmune diseases	14
PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis	14
Modulation of the tumor micro-environment by CD8+ T cell-derived cytokines	14
Immune responses to Toxoplasma gondii	14
Transcriptional and translational control of Foxp3+ regulatory T cell functional adaptation to inflammation	14
Indole derivatives, microbiome and graft versus host disease	14
Human MALT1 deficiency and predisposition to infections	14
Neuro-innate immune interactions in gut mucosal immunity	14
Microbiota–immune interactions in asthma pathogenesis and phenotype	13
Bioinspired vaccines to enhance MHC class-I antigen cross-presentation	13
Mesothelial cells regulate immune responses in health and disease: role for immunotherapy in malignant mesothelioma	13
The role of MHC I protein dynamics in tapasin and TAPBPR-assisted immunopeptidome editing	13
A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans	13
Next generation immunotherapy: enhancing stemness of polyclonal T cells to improve anti-tumor activity	13
Resolving adjuvant mode of action to enhance vaccine efficacy	13
Neuron-intrinsic immunity to viruses in mice and humans	13
Infections in the monogenic autoimmune syndrome APECED	13
Immunometabolism and autoimmunity	13
New insights on T-cell self-tolerance	12
Inborn errors of IKAROS and AIOLOS	12
Innate myeloid cells in the tumor microenvironment	12
Safety switches for adoptive cell therapy	12
Dissecting the antibody-OME: past, present, and future	12
Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy	12
Necroptotic movers and shakers: cell types, inflammatory drivers and diseases	12
Endogenous TAP-independent MHC-I antigen presentation: not just the ER lumen	11
Microbiota and human allergic diseases: the company we keep	11
The love and hate relationship of HLA-DM/DO in the selection of immunodominant epitopes	11
Function, occurrence and inhibition of different forms of BAFF	11
Aspirin-exacerbated respiratory disease	11
Vaccines as remedy for antimicrobial resistance and emerging infections	11
ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency	11
MR1: a multi-faceted metabolite sensor for T cell activation	11
Bacteria-immune cells dialog and the homeostasis of the systems	11
Stromal cell control of conventional and ectopic germinal centre reactions	11
Innate control of adaptive immunity and adaptive instruction of innate immunity: bi-directional flow of information	10
BAFF signaling in B cell metabolism	10
Why TAPBPR? Implications of an additional player in MHC class I peptide presentation	10
Inflammation following trypanosome infection and persistence in the skin	10
FALC stromal cells define a unique immunological niche for the surveillance of serous cavities	10
Better living through chemistry: CRISPR/Cas engineered T cells for cancer immunotherapy	10
Immune responses and exacerbations in severe asthma	10

The nonclassical immune surveillance for ERAAP function	10
Co-evolution of mutagenic genome editors and vertebrate adaptive immunity	9
Impact of the microbiome on tumor immunity	9
Polymorphisms of HLA-B: influences on assembly and immunity	9
Genetic and immunological basis of human African trypanosomiasis	9
Recent insights into innate immune nucleic acid sensing during viral infection	9
Keeping up with the stress of antibody production: BAFF and APRIL maintain memory plasma cells	9
Constitutive and latent immune mechanisms exert ‘silent’ control of virus infections in the central nervous system	9
Stromal cells and immune cells involved in formation of lymph nodes and their niches	9
Neuronal regulation of innate lymphoid cell responses	9
Understanding immune variation for improved translational medicine	9
The actin cytoskeleton and mast cell function	9
Immunotherapy in allergic diseases — improved understanding and innovation for enhanced effectiveness	9
Exploiting ECM remodelling to promote immune-mediated tumour destruction	8
Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs	8
Metabolic regulation of innate immune cell phenotypes during wound repair and regeneration	8
Mesenchymal perivascular cells in immunity and disease	8
Monogenic susceptibility to live viral vaccines	8
Life-or-death decisions in plant immunity	8
Candidiasis in patients with APS-1: low IL-17, high IFN-γ, or both?	8
Human inborn errors of immunity to oncogenic viruses	8
Epigenetics of the antibody and autoantibody response	8
Immunological lessons from genome-wide association studies of infections	8
T follicular helper cells in IgE-mediated pathologies	8
The Ins and Outs of TAPBPR	8
Local and remote interactions between macrophages and microglia in neurological conditions	8
How to bridle a neutrophil	8
Mechanisms encoding STAT functional diversity for context-specific inflammatory responses	8
Functional heterogeneity and adaptation of naive T cells in response to tonic TCR signals	8
Clean up by aisle 2: roles for IL-2 receptors in host defense and tolerance	8
Spontaneous and induced adaptive immune responses in Alzheimer’s disease: new insights into old observations	8
Asthma-chronic obstructive pulmonary disease overlap syndrome	8
Messenger ribonucleic acid vaccines against infectious diseases: current concepts and future prospects	7
Inborn errors of autophagy and infectious diseases	7
One genome, many cell states: epigenetic control of innate immunity	7
Myeloid cells in sensing of tissue damage	7
Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses	7
Navigating the complexity of chronic HIV-1 associated immune dysregulation	7
Lung tissue-resident memory T cells: the gatekeeper to respiratory viral (re)-infection	7
Systems immunology	7
Bidirectional sensory neuron–immune interactions: a new vision in the understanding of allergic inflammation	7
Monogenic autoimmunity and infectious diseases: the double-edged sword of immune dysregulation	7
Host genetics of innate immune system in infection	7
Infections in activated PI3K delta syndrome (APDS)	7
Immune outposts in the adventitia: One foot in sea and one on shore	7
Missed opportunities for vaccination in Africa	7
Synthetic receptors for logic gated T cell recognition and function	7
Regulation of myeloid-cell activation	7
Increasing hepatitis B vaccination coverage of healthcare workers — global lessons for South Africa	7