Current Opinion in Immunology

Article	Citations
COVID-19 vaccines	223
Type I interferon in the pathogenesis of systemic lupus erythematosus	137
Tryptophan and indole metabolism in immune regulation	110
The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease	107
The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention	94
Vaccine hesitancy in migrant communities: a rapid review of latest evidence	75
The role of CD4 T cells in rejection of solid tumors	65
Ebola virus disease: current vaccine solutions	61
Type I interferons and SARS-CoV-2: from cells to organisms	60
CBASS phage defense and evolution of antiviral nucleotide signaling	55
Anti-interferon-γ autoantibody-associated immunodeficiency	53
The politics of Covid-19 vaccine confidence	53
A critical review of measures of childhood vaccine confidence	52
Natural killers or ILC1s? That is the question	52
Cytokines and transcription factors in the differentiation of CD4+ T helper cell subsets and induction of tissue inflammation and autoimmunity	50
Viral vector vaccines	49
Detrimental activation of AhR pathway in cancer: an overview of therapeutic strategies	49
The multifaceted functions of follicular regulatory T cells	49
Exploring cardiac macrophage heterogeneity in the healthy and diseased myocardium	48
Sensing and clearance of apoptotic cells	47
Gut microbiome-mediated regulation of neuroinflammation	46
HLA variation and antigen presentation in COVID-19 and SARS-CoV-2 infection	46
Innate lymphoid cells: from helper to killer	45
The innate immune system and cell death in autoinflammatory and autoimmune disease	45
Trained immunity: implications for vaccination	45

Tuning tuft cells: new ligands and effector functions reveal tissue-specific function	44
Regulation of host physiology and immunity by microbial indole-3-aldehyde	44
Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections	44
The high affinity IgE receptor: a signaling update	41
Inhibitory receptor agonists: the future of autoimmune disease therapeutics?	40
New insights into B cells as antigen presenting cells	38
Diversity and function of brain-associated macrophages	38
Regulation of innate immunity by Nrf2	35
New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression	34
Signals governing monocyte differentiation during inflammation	34
Major histocompatibility complex (MHC) class I and class II proteins: impact of polymorphism on antigen presentation	33
Charcot–Leyden crystals and other protein crystals driving type 2 immunity and allergy	33
Inborn errors of STAT1 immunity	33
Mechanisms for control of skin immune function by the microbiome	33
Interventions for vaccine hesitancy	33
MHC I assembly and peptide editing — chaperones, clients, and molecular plasticity in immunity	32
Mast cell tryptases in allergic inflammation and immediate hypersensitivity	32
The role of enteric glia in intestinal immunity	31
There is no gene for CVID — novel monogenetic causes for primary antibody deficiency	31
Intrinsic and extrinsic regulation of IgE B cell responses	31
Supply and delivery of vaccines for global health	29
TACI deficiency — a complex system out of balance	29
Inflammasome activation and evasion by bacterial pathogens	29
Immune checkpoint receptors in autoimmunity	29
Tryptophan metabolism in brain tumors — IDO and beyond	28
Inborn errors of IL-6 family cytokine responses	28
Innate immune defenses at the maternal-fetal interface	28
T cell immunity to cytomegalovirus infection	27
Emerging roles of circular RNAs in innate immunity	27
Mycobacterial diseases in patients with inborn errors of immunity	27
Adverse events induced by immune checkpoint inhibitors	27
Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling	26
Role of the NF-κB system in context-specific tuning of the inflammatory gene response	26
Resolving adjuvant mode of action to enhance vaccine efficacy	25
Principles and practical applications of structure-based vaccine design	25
Modulation of the tumor micro-environment by CD8+ T cell-derived cytokines	24
Immune responses to Toxoplasma gondii	24
Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection	24
BAFF signaling in health and disease	23
Immunity to EBV as revealed by immunedeficiencies	23
Down syndrome and type I interferon: not so simple	22
Reflection: burden of cervical cancer in Sub-Saharan Africa and progress with HPV vaccination	22
PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis	22
Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces	21
Resistance mechanisms to checkpoint inhibitors	19
Safety switches for adoptive cell therapy	19
The double life of serotonin metabolites: in the mood for joining neuronal and immune systems	19
Autoimmunity, IgE and FcεRI-bearing cells	19
New insights into human immunity from ancient genomics	19
Adoptive T cell therapy of solid tumors: time to team up with immunogenic chemo/radiotherapy	18

The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease	18
Manipulating antigen presentation for antigen-specific immunotherapy of autoimmune diseases	18
Epigenetic adjuvants: durable reprogramming of the innate immune system with adjuvants	18
Keeping up with the stress of antibody production: BAFF and APRIL maintain memory plasma cells	18
Cross-reactivity between microbial and tumor antigens	18
Innate immune sensing by epithelial barriers	18
Mechanisms of response and resistance to CAR T cell therapies	18
Infections in the monogenic autoimmune syndrome APECED	18
Control of regulatory T cell homeostasis	17
Emerging dimensions of cellular cGAS-STING signaling	17
A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans	17
BAFF signaling in B cell metabolism	16
Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy	16
Neuron-intrinsic immunity to viruses in mice and humans	16
Indole derivatives, microbiome and graft versus host disease	16
Dynamics of MHC-I molecules in the antigen processing and presentation pathway	16
Neuro-innate immune interactions in gut mucosal immunity	15
Necroptotic movers and shakers: cell types, inflammatory drivers and diseases	15
Transcriptional and translational control of Foxp3+ regulatory T cell functional adaptation to inflammation	15
Tumor immune evasion through loss of MHC class-I antigen presentation	15
Next generation immunotherapy: enhancing stemness of polyclonal T cells to improve anti-tumor activity	15
Human MALT1 deficiency and predisposition to infections	15
Innate control of adaptive immunity and adaptive instruction of innate immunity: bi-directional flow of information	14
Bioinspired vaccines to enhance MHC class-I antigen cross-presentation	14
Immunometabolism and autoimmunity	14
Recent insights into innate immune nucleic acid sensing during viral infection	14
Function, occurrence and inhibition of different forms of BAFF	14
Microbiota and human allergic diseases: the company we keep	14
Better living through chemistry: CRISPR/Cas engineered T cells for cancer immunotherapy	14
Spontaneous and induced adaptive immune responses in Alzheimer’s disease: new insights into old observations	13
The actin cytoskeleton and mast cell function	13
The role of MHC I protein dynamics in tapasin and TAPBPR-assisted immunopeptidome editing	13
Inborn errors of IKAROS and AIOLOS	13
Lung tissue-resident memory T cells: the gatekeeper to respiratory viral (re)-infection	13
Genetic and immunological basis of human African trypanosomiasis	13
ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency	13
T follicular helper cells in IgE-mediated pathologies	12
Human inborn errors of immunity to oncogenic viruses	12
Constitutive and latent immune mechanisms exert ‘silent’ control of virus infections in the central nervous system	12
Innate myeloid cells in the tumor microenvironment	12
Life-or-death decisions in plant immunity	12
Trogocytosis and cross-dressing in antigen presentation	12
Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite	12
Neuronal regulation of innate lymphoid cell responses	12
Immune responses and exacerbations in severe asthma	12
The nonclassical immune surveillance for ERAAP function	12
Functional heterogeneity and adaptation of naive T cells in response to tonic TCR signals	11
Bidirectional sensory neuron–immune interactions: a new vision in the understanding of allergic inflammation	11
Regulation of myeloid-cell activation	11
Epigenetics of the antibody and autoantibody response	10
Missed opportunities for vaccination in Africa	10
‘Persistent germinal center responses: slow-growing trees bear the best fruits’	10
Why TAPBPR? Implications of an additional player in MHC class I peptide presentation	10
Clean up by aisle 2: roles for IL-2 receptors in host defense and tolerance	10
Exploiting ECM remodelling to promote immune-mediated tumour destruction	10
Infections in activated PI3K delta syndrome (APDS)	10
Candidiasis in patients with APS-1: low IL-17, high IFN-γ, or both?	10
Messenger ribonucleic acid vaccines against infectious diseases: current concepts and future prospects	10
One genome, many cell states: epigenetic control of innate immunity	10
Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty	10
Impact of the microbiome on tumor immunity	9
Local and remote interactions between macrophages and microglia in neurological conditions	9
T-bethighCD21low B cells: the need to unify our understanding of a distinct B cell population in health and disease	9
Cell entry and innate sensing shape adaptive immune responses to adenovirus-based vaccines	9
ILC2s – development, divergence, dispersal	9
cGAS-like receptor-mediated immunity: the insect perspective	9
Bystander activation in memory and antigen-inexperienced memory-like CD8 T cells	9
Z-form nucleic acid-binding protein 1 (ZBP1) as a sensor of viral and cellular Z-RNAs: walking the razor's edge	9
Mechanisms encoding STAT functional diversity for context-specific inflammatory responses	9
Immunometabolic alterations in lupus: where do they come from and where do we go from there?	9
T follicular helper cells and their impact on humoral responses during pathogen and vaccine challenge	9
Positive and negative roles of lipids in mast cells and allergic responses	9
Evolving concepts of host–pathobiont interactions in autoimmunity	9
Type-1 interferon-dependent and -independent mechanisms in cyclic GMP–AMP synthase–stimulator of interferon genes-driven auto-inflammation	8
Metabolic regulation of innate immune cell phenotypes during wound repair and regeneration	8
Revisiting the role of MRGPRX2 on hypersensitivity reactions to neuromuscular blocking drugs	8
T-cell–B-cell collaboration in the lung	8
The vicious cycle governing the brain–immune system relationship in neurodegenerative diseases	8
Ubiquitination and cell-autonomous immunity	8
Immunological lessons from genome-wide association studies of infections	8

Innate immune activation and modulatory factors of Helicobacter pylori towards phagocytic and nonphagocytic cells	8
How to bridle a neutrophil	8
The next frontier in vaccine design: blending immune correlates of protection into rational vaccine design	8
Microevolution of Pseudomonas aeruginosa in the airways of people with cystic fibrosis	8
Immunological insights in the treatment of chronic hepatitis B	8
Monogenic susceptibility to live viral vaccines	8
Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses	8
Animal models of shigellosis: a historical overview	8
Determinants of persistent Salmonella infections	8
Synthetic receptors for logic gated T cell recognition and function	8
Germinal center reaction and output: recent advances	7
Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells	7
Navigating the complexity of chronic HIV-1 associated immune dysregulation	7
Host genetics of innate immune system in infection	7
MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention	7
Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes	7
Making sense of plasma cell heterogeneity	7
Granulocytes subsets and their divergent functions in host resistance to Mycobacterium tuberculosis — a ‘tipping-point’ model of disease exacerbation	7
Monogenic autoimmunity and infectious diseases: the double-edged sword of immune dysregulation	7
Classical- and bioconjugate vaccines: comparison of the structural properties and immunological response	7
Increasing hepatitis B vaccination coverage of healthcare workers — global lessons for South Africa	7
Humoral immunity at the brain borders in homeostasis	7
Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation	7
Cellular interactions in resident memory T cell establishment and function	7
Inborn errors of autophagy and infectious diseases	7
Myeloid cells in sensing of tissue damage	7
Innate sensing of mRNA vaccines	7
Diversity of human NK cell developmental pathways defined by single-cell analyses	7
Molecular regulation and dysregulation of T follicular helper cells – learning from inborn errors of immunity	7
BAFF receptor polymorphisms and deficiency in humans	7
Stromal cell regulation of inflammatory responses	7
Accelerating clinical trial development in vaccinology: COVID-19 and beyond	7