Biofactors

Papers
(The median citation count of Biofactors is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
The role of plant‐derived natural antioxidants in reduction of oxidative stress200
Luteolin as a modulator of skin aging and inflammation179
Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue142
Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review97
Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis84
Luteolin, inflammation and cancer: Special emphasis on gut microbiota59
COVID‐19, microthromboses, inflammation, and platelet activating factor51
Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action49
Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals48
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?46
Targeting of the tumor microenvironment by curcumin42
The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review41
Ischemic stroke, obesity, and the anti‐inflammatory role of melatonin40
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer39
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,36
Interactions between dietary polyphenols and aging gut microbiota: A review35
The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective34
Quercetin prevents cadmium chloride‐induced hepatic steatosis and fibrosis by downregulating the transcription ofmiR‐2134
A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β‐caryophyllene32
Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells32
Platelet Activating Factor (PAF): A Mediator of Inflammation30
Dioscin: A review on pharmacological properties and therapeutic values29
Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials29
Ginger and its constituents: Role in treatment of inflammatory bowel disease29
Polyphenols as modulators of pre‐established gut microbiota dysbiosis: State‐of‐the‐art28
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate26
Promising effects of gingerol against toxins: A review article25
Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes25
Powerful anti‐inflammatory action of luteolin: Potential increase with IL‐3825
Secondary CoQ10 deficiency, bioenergetics unbalance in disease and aging24
Neuroinflammation in Alzheimer's disease and beneficial action of luteolin24
A pilot study of the effects of crocin on high‐density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome: A randomized clinical trial23
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency23
The HIF‐1/SNHG1/miR‐199a‐3p/TFAM axis explains tumor angiogenesis and metastasis under hypoxic conditions in breast cancer23
Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism22
Revisiting the therapeutic potential of tocotrienol22
Berberine promotes peri‐implant osteogenesis in diabetic rats by ROS‐mediated IRS‐1 pathway22
Ginger: A complementary approach for management of cardiovascular diseases20
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis20
Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine20
Recent research progress of biologically active peptides20
Retracted: Systemic inflammation and oxidative stress induced by inhaled paraquat in rat improved by carvacrol, possible role of PPARγ receptors20
Specialized proresolving mediators in infection and lung injury20
Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion19
Golgi stress response: A regulatory mechanism of Golgi function19
Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review19
Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update19
Anti‐neuroinflammatory effect of daidzein in human hypothalamic GnRH neurons in an in vitro membrane‐based model19
Catalase deficiency induces reactive oxygen species mediated pexophagy and cell death in the liver during prolonged fasting18
Stem cell‐based therapies for cardiac diseases: The critical role of angiogenic exosomes18
Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system18
Analytical determinations of luteolin18
Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI117
Melatonin ameliorates arsenic‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats17
Role of luteolin in overcoming Parkinson's disease17
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases17
The cardioprotective effects of hydrogen sulfide by targeting endoplasmic reticulum stress and the Nrf2 signaling pathway: A review17
Mangiferin and organ fibrosis: A mini review17
The role of biofactors in the prevention and treatment of age‐related diseases17
Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway16
Reactive oxygen species as a double‐edged sword: The role of oxidative enzymes in antitumor therapy16
Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro16
Ammonia induces autophagy via circ‐IFNLR1/miR‐2188‐5p/RNF182 axis in tracheas of chickens16
BCL‐6 promotes the methylation of miR‐34a by recruiting EZH2 and upregulating CTRP9 to protect ischemic myocardial injury15
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer15
Altered triglyceride glucose index and fasted serum triglyceride high‐density lipoprotein cholesterol ratio predict incidence of cardiovascular disease in the Mashhad cohort study15
Knockdown of lncRNA TUG1 attenuates cerebral ischemia/reperfusion injury through regulating miR‐142‐3p15
Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat14
The role of exosomal non‐codingRNAsin aging‐related diseases14
Melatonin ameliorates trimethyltin chloride‐induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1‐Nrf2/ARE axis‐mediated pyroptosis14
Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans14
Resolvin D1: A key endogenous inhibitor of neuroinflammation14
Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA‐29a‐3p/CCNT2 axis14
CDCA7‐regulated inflammatory mechanism through TLR4/NF‐κB signaling pathway in stomach adenocarcinoma13
Rapid and simultaneous determination of histidine metabolism intermediates in human and mouse microbiota and biomatrices13
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance13
Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells13
Luteolin supplements: All that glitters is not gold12
alpha‐Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis12
LncRNA LOC100507144 acts as a novel regulator of CD44/Nanog/Sox2/miR‐302/miR‐21 axis in colorectal cancer12
Promising influences of gingerols against metabolic syndrome: A mechanistic review12
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome12
miR‐23b/TAB3/NF‐κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia–reperfusion in rats: The protective effect of chlorogenic acid12
Crocin attenuates inflammation of lung tissue in ovalbumin‐sensitized mice by altering the expression of endoplasmic reticulum stress markers11
Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity11
Production, health‐promoting properties and characterization of bioactive peptides from cereal and legume grains11
Biological and pharmacological activities of noscapine: Focusing on its receptors and mechanisms11
Altered type I collagen networking in osteoporotic human femoral head revealed by histomorphometric and Fourier transform infrared imaging correlated analyses11
A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF‐κB inhibition and Nrf2 activation10
Neutrophil to lymphocyte ratio is not related to carotid atherosclerosis progression and cardiovascular events in the primary prevention of cardiovascular disease: Results from the IMPROVE 10
Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP‐2/‐9 expression and activity10
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation10
Notch1 signaling enhances collagen expression and fibrosis in mouse uterus10
Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial‐mesenchymal transformation in a mouse model of myocarditis10
NRF2, a crucial modulator of skin cells protection against vitiligo, psoriasis, and cancer10
Berberine ameliorates neuronal AD‐like change via activating Pi3k/PGCε pathway9
Novel roles of Tsukushi in signaling pathways and multiple disease processes9
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications9
Tenascin‐C regulates migration of SOX10 tendon stem cells via integrin‐α9 for promoting patellar tendon remodeling9
PDIA4, a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue9
Mechanisms of cancer cell death induction by triptolide9
Effects of rosmarinic acid, carnosic acid, rosmanol, carnosol, and ursolic acid on the pathogenesis of respiratory diseases9
Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor p9
O‐GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics‐oriented study9
Integrated analysis of the prognostic values of RNA‐binding proteins in head and neck squamous cell carcinoma9
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?9
FAM84B acts as a tumor promoter in human glioma via affecting the Akt/GSK‐3β/β‐catenin pathway9
Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review8
Carboxylative efficacy of trans and cisMK7 and comparison with other vitamin K isomers8
Crocetin regulates Th1/Th2 and Th17/Treg balances, nitric oxide production, and nuclear localization of NF‐κB in Th2‐provoked and norm8
Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans8
The possible role of the nucleoside adenosine in countering skin aging: A review8
Tau, tau kinases, and tauopathies: An updated overview8
Time‐based investigation of urinary metabolic markers for Type 2 diabetes: Metabolomics approach for diabetes management8
New transcriptome and clinical findings of platelet‐activating factor in chronic spontaneous urticaria: Pathogenic and treatment relevance8
Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy8
Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins8
Naringenin protects swine testis cells from bisphenol A‐induced apoptosis via Keap1/Nrf2 signaling pathway8
Fisetin, a major component derived from mulberry (Morus australis Poir.) leaves, prevents vascular abnormal contraction8
Redox‐sensitive signaling pathways in renal cell carcinoma8
Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation7
Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis7
Cip2A modulates osteogenic differentiation via the ERK‐Runx2 pathway in MG63 cells7
Melatonin: A regulator of the interplay between FoxO1, miR96, and miR215 signaling to diminish the growth, survival, and metastasis of murine adenocarcinoma7
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma7
Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK‐3β/β‐catenin pathway7
NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products7
Noninvasive instrumental evaluation of coenzyme Q10 phytosome on endothelial reactivity in healthy nonsmoking young volunteers: A double‐blind, randomized, placebo‐controlled cro7
Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)7
Human antigen R (HuR) and Cold inducible RNA‐binding protein (CIRP) influence intestinal mucosal barrier function in ulcerative colitis by competitive regulation on Claudin17
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones6
The dietary carcinogen PhIP activates p53‐dependent DNA damage response in the colon of CYP1A‐humanized mice6
Wnt inhibitory 1 ameliorates neovascularization and attenuates photoreceptor injury in an oxygen‐induced retinopathy mouse model6
Factors determining the serum 25‐hydroxyvitamin D response to vitamin D supplementation: Data mining approach6
Hsp90 inhibition protects brain endothelial cells against LPS‐induced injury6
Application of peptide biomarkers in life analysis based on liquid chromatography–mass spectrometry technology6
Luteolin: The wonder flavonoid6
Clusterin, paraoxonase 1, and myeloperoxidase alterations induce high‐density lipoproteins dysfunction and contribute to peripheral artery disease; aggravation by type 2 diabetes mellitus6
Suffruticosol A elevates osteoblast differentiation targeting BMP2‐Smad/1/5/8‐RUNX2 in pre‐osteoblasts6
Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases6
A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes5
Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease5
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure‐induced cardiotoxicity in swine5
Light‐activatable multifunctional paclitaxel nanoprodrug for synergistic chemo‐photodynamic therapy in liver cancer5
Interleukin‐9 deficiency affects lipopolysaccharide‐induced macrophage‐related oxidative stress and myocardial cell apoptosis via the Nrf2 pathway both in vivo and in vitro5
Melatonin mediated activation of MAP kinase pathway may reduce DNA damage stress in plants: A review5
Modulation of CD36‐mediated lipid accumulation and senescence by vitamin E analogs in monocytes and macrophages5
Plasmalogens and platelet‐activating factor roles in chronic inflammatory diseases5
Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle5
Role of ferroptosis inhibitors in the management of diabetes5
Roles of circular RNAs in osteogenic/osteoclastogenic differentiation5
Uptake and time‐dependent subcellular localization of native and micellar curcumin in intestinal cells5
Macrophage migration inhibitory factor deficiency aggravates effects of fructose‐enriched diet on lipid metabolism in the mouse liver5
SP1/CTR1‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration5
Neuroprotective effects of vitamin D in an Alzheimer's disease rat model: Improvement of mitochondrial dysfunction via calcium/calmodulin‐dependent protein kinase kinase 2 activa5
Protein kinase G phosphorylates the Alzheimer's disease‐associated tau protein at distinct Ser/Thr sites5
Therapeutic potential of phytochemicals for cystic fibrosis5
HDL‐mediated reduction of cholesterol content inhibits the proliferation of prostate cancer cells induced by LDL: Role of ABCA1 and proteasome inhibition5
Cardiac troponins: Mechanisms of release and role in healthy and diseased subjects4
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role ofSIRT14
Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease4
Thyroid hormones inhibit apoptosis of macrophage induced by oxidized low‐density lipoprotein4
The role of LncRNA‐regulated autophagy in AKI4
Exploring the therapeutic potential of naturally occurring piceatannol in non‐communicable diseases4
Lnc‐hipk1 inhibits mouse adipocyte apoptosis as a sponge of miR‐4974
PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects4
The unique molecular targets associated antioxidant and antifibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach4
Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases4
Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88‐dependent acceleration of hyperlipidaemia by Gram‐positive cell wall components4
N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning4
Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors4
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis4
Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects4
The role of P450 enzymes in malaria and other vector‐borne infectious diseases4
Platelet‐activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury4
Molecular basis of progressive familial intrahepatic cholestasis 3. A proteomics study4
Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A2 activity and traditional cardiovascular risk factors4
22‐kD growth hormone‐induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation4
α‐Asarone alleviates allergic asthma by stabilizing mast cells through inhibition of ERK/JAK2‐STAT3 pathway4
Hsa_circ_0045714 induced by eupatilin has a potential to promote fracture healing4
Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers3
Erythrocytes' surface properties and stiffness predict survival and functional decline in ALS patients3
Altered rich‐club organization of brain functional network in autism spectrum disorder3
Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review3
Astrocytic aerobic glycolysis provides lactate to support neuronal oxidative metabolism in the hippocampus3
Platelet‐activating factor as an endogenous cofactor of food anaphylaxis3
Insights into the antiosteoporotic mechanism of the soy‐derived isoflavone genistein: Modulation of the Wnt/beta‐catenin signaling3
Nutrient‐sensing amyloid metastasis3
Modulatory effects of point‐mutated IL‐32θ (A94V) on tumor progression in triple‐negative breast cancer cells3
Quercetin attenuates angiotensin II‐induced proliferation of vascular smooth muscle cells and p53 pathway activation in vitro and in vivo3
FERM domain‐containing protein 6 exerts a tumor‐inhibiting role in thyroid cancer by antagonizing oncogenic YAP13
Metformin and thymoquinone co‐treatment enhance 5‐fluorouracil cytotoxicity by suppressing the PI3K/mTOR/HIF1α pathway and increasing oxidative stress in colon cancer 3
Biochemical and cellular studies of three human 3‐phosphoglycerate dehydrogenase variants responsible for pathological reduced L‐serine levels3
Dapagliflozin improves diabetic cognitive impairment via indirectly modulating the mitochondria homeostasis of hippocampus in diabetic mice3
Regulation of citrulline synthesis in human enterocytes: Role of hypoxia and inflammation3
Nomilin and its analogue obacunone alleviate NASH and hepatic fibrosis in mice via enhancing antioxidant and anti‐inflammation capacity3
The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy3
Breast cancer diagnosis and management guided by data augmentation, utilizing an integrated framework of SHAP and random augmentation3
Lemon extract reduces the hepatic oxidative stress and persulfidation levels by upregulating the Nrf2 and Trx1 expression in old rats3
Topical application of gemcitabine generates microvesicle particles in human and murine skin2
The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense2
Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice2
Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae2
Shaggy functions downstream of dMyc and their concurrent downregulation confers additive rescue against tau toxicity in Drosophila2
The influence of redox modulation on hypoxic endothelial cell metabolic and proteomic profiles through a small thiol‐based compound tuning glutathione and thioredoxin systems2
A glimpse into the structural properties of α‐synuclein oligomers2
Longevity effects of hispidol in Caenorhabditis elegans2
Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation2
High‐density lipoprotein lipid peroxidation as a diagnostics biomarker in coronary artery disease2
Platelet activating factor: Have we been missing the forest for the trees?2
Blockade of PD‐1 and CTLA‐4: A potent immunotherapeutic approach for hepatocellular carcinoma2
New biomarkers and therapeutic targets of human liver cancer: Transcriptomic findings2
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK‐mTOR pathway in sheep associated with prolificacy2
Gut microbiota contribution to selenium deficiency‐induced gut–liver inflammation2
Maternal erythrocyte fatty acid composition as a predictive marker for pregnancy health2
DISC1 inhibits GSK3β activity to prevent tau hyperphosphorylation under diabetic encephalopathy2
Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue2
Sulforaphane prevents diabetes‐induced hepatic ferroptosis by activating Nrf2 signaling axis2
Ameliorating diabetes‐induced testicular dysfunction by modulating PKC/Nrf2/Bcl‐2 signaling: Protective role of sulbutiamine2
miR‐222 exerts negative regulation on insulin signaling pathway in 3T3‐L1 adipocytes2
Celastrol attenuates high‐fructose diet‐induced inflammation and insulin resistance via inhibition of 11β‐hydroxysteroid dehydrogenase type 1 activity in rat adipose tissues2
Endogenous chemicals guard health through inhibiting ferroptotic cell death2
Integration of miRNA in exosomes and single‐cell RNA‐seq profiles in endemic osteoarthritis, Kashin–Beck disease2
miR‐34a/SIRT1/HIF‐1α axis is involved in cardiac angiogenesis of type 2 diabetic rats: The protective effect of sodium butyrate combined with treadmill exercise2
Profiling of lysophosphatidylethanolamine molecular species in human serum and in silico prediction of the binding site on albumin2
Natural product fargesin interferes with H3 histone lactylation via targeting PKM2 to inhibit non‐small cell lung cancer tumorigenesis2
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