Biofactors

Article	Citations
Issue Highlights	297
Issue Information	71
Issue Information	54
New biomarkers and therapeutic targets of human liver cancer: Transcriptomic findings	52
Myasthenia gravis: The pharmacological basis of traditional Chinese medicine for its clinical application	52
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis	51
Attenuation of p38 MAPK/NF‐κB/TRPV1/CGRP is involved in the antinociceptive effect of hesperidin methyl chalcone and taxifolin in paclitaxel‐indu	49
Golgi stress response: A regulatory mechanism of Golgi function	45
	43
Reactive oxygen species as a double‐edged sword: The role of oxidative enzymes in antitumor therapy	43
Issue Information	42
Long non‐coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR‐4673/TPX2 axis and activating Wnt/β‐catenin signaling pathway	41
Retraction	38
Lactate dehydrogenase A is implicated in the pathogenesis of B‐cell lymphoma through regulation of the FER signaling pathway	37
Recent research progress of biologically active peptides	37
Issue Information ‐ Cover	36
The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy	35
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?	34
Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway	32
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance	31
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia	28
The possible role of the nucleoside adenosine in countering skin aging: A review	28
Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development	27
Cip2A modulates osteogenic differentiation via the ERK‐Runx2 pathway in MG63 cells	27
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role ofSIRT1	26

Retraction	26
Berberine chloride loaded nano‐PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis	25
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	24
Correction to “Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro”	24
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,	23
N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning	22
Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells	22
Deletion of NRF2 disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging	21
High glucose leads to redistribution of the proteasomal system	21
Deciphering the role of Zn2+‐binding histidines from TIA‐1 on the assembly and dynamics of stress granules	21
Issue Information ‐ Cover	20
Retraction	20
Control of Mycobacterium tuberculosis infection in the elderly: Is there a role for epigenetic reprogramming reversal?	20
Redox‐sensitive signaling pathways in renal cell carcinoma	20
Agmatine suppresses glycolysis via the PI3K/Akt/mTOR/HIF‐1α signaling pathway and improves mitochondrial function in microglia exposed to lipopolysaccharide	20
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis	20
Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type‐1 antagonistic mechanism and alters cellular metabolism	20
Crocetin regulates Th1/Th2 and Th17/Treg balances, nitric oxide production, and nuclear localization of NF‐κB in Th2‐provoked and norm	19
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Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans	19
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia	19
The HIF‐1/SNHG1/miR‐199a‐3p/TFAM axis explains tumor angiogenesis and metastasis under hypoxic conditions in breast cancer	19
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma	19
Promising effects of gingerol against toxins: A review article	18
Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function	18
Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation	18
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency	18
A novel peptide derived from Haematococcus pluvialis residue balanced lipid metabolism through NHR‐49/PPARα and AAK‐2/AMPK pathways in Caenorhabdi	17
Issue Information	17
Issue Information ‐ Cover	17
Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells	17
Deubiquitinase PSMD14 promotes tumorigenicity of glioblastoma by deubiquitinating and stabilizing β‐catenin	16
Issue Information	16
Issue Information ‐ Cover	16
Proteomic profiling of intestinal epithelial‐like cell‐derived exosomes regulated by epigallocatechin gallate	15
Issue Information	15
A pilot study of the effects of crocin on high‐density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome: A randomized clinical trial	15
Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential	15
Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy	15
Erratum	14
Maternal erythrocyte fatty acid composition as a predictive marker for pregnancy health	14
	14
A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation	14
Melatonin: A regulator of the interplay between FoxO1, miR96, and miR215 signaling to diminish the growth, survival, and metastasis of murine adenocarcinoma	14
SP1/CTR1‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration	13
Gut microbiota contribution to selenium deficiency‐induced gut–liver inflammation	13
Targeting of the tumor microenvironment by curcumin	13
Effects of calciprotein particles on EMT induction in an in vitro 3D‐cultured proximal tubule epithelial cell model of CKD	12
Nuclear receptor 4A1 (NR4A1) upregulated by n‐butylidenephthalide via the mitogen‐activated protein kinase (MAPK) pathway ameliorates drug‐induced gingival enlargement	12
Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway	12

Issue Information	12
Retraction	11
Harnessing tumor‐derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer	11
Echinacoside promotes collagen synthesis and survival via activation of IGF‐1 signaling to alleviate UVB‐induced dermal fibroblast photoaging	11
Insights into an indolicidin‐derived low‐toxic anti‐microbial peptide's efficacy against bacterial cells while preserving eukaryotic cell viability	11
Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context	11
Navigating the immune landscape with plasma cells: A pan‐cancer signature for precision immunotherapy	10
Combinatorial effect of Apigenin‐resveratrol on white adipocyte plasticity and trans‐differentiation for activating lipid metabolism	10
Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor p	10
Correction to “Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition”	10
Non‐beneficial effects of resveratrol on renal epithelial cell cultures: Implications in cell differentiation	10
Dioscin: A review on pharmacological properties and therapeutic values	10
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Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration	9
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Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high‐fat diet	9
Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed flavanols	9
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The role of LncRNA‐regulated autophagy in AKI	9
Leveraging supramolecular systems in biomedical breakthroughs	9
miR‐222 exerts negative regulation on insulin signaling pathway in 3T3‐L1 adipocytes	9
Retraction	9
Identification and validation of the TRHDE‐AS1/hsa‐miR‐449a/ADAMTS5 axis as a novel prognostic biomarker in prostate cancer	9
Erratum to “Revisiting the therapeutic potential of tocotrienol”	9
Therapeutic potential of phytochemicals for cystic fibrosis	8
miR‐23b/TAB3/NF‐κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia–reperfusion in rats: The protective effect of chlorogenic acid	8
Issue Information	8
	8
FERM domain‐containing protein 6 exerts a tumor‐inhibiting role in thyroid cancer by antagonizing oncogenic YAP1	8
UPS and Kinases—Gatekeepers of the G1/S Transition	8
Issue Information ‐ Cover	8
Issue Information ‐ Cover	8
Mechanisms of cancer cell death induction by triptolide	8
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications	8
Issue Information ‐ Cover	8
Melatonin ameliorates trimethyltin chloride‐induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1‐Nrf2/ARE axis‐mediated pyroptosis	8
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Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle	7
Retraction	7
Resolvin D1: A key endogenous inhibitor of neuroinflammation	7
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?	7
Issue Information ‐ Cover	7
Torpor‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides	7
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure‐induced cardiotoxicity in swine	7
Altered rich‐club organization of brain functional network in autism spectrum disorder	7
Issue Information ‐ Cover	7
Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes	7
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases	6
The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review	6
alpha‐Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis	6
Carboxylative efficacy of trans and cisMK7 and comparison with other vitamin K isomers	6
DISC1 inhibits GSK3β activity to prevent tau hyperphosphorylation under diabetic encephalopathy	6
Noninvasive instrumental evaluation of coenzyme Q10 phytosome on endothelial reactivity in healthy nonsmoking young volunteers: A double‐blind, randomized, placebo‐controlled cro	6
Crosstalk among miR‐29, α‐SMA, and TGFβ1/β3 in melatonin‐induced exosome (Mel‐prExo) treated human limbal mesenchymal stem cells (hLMSCs): An ins	6
O‐GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum	5
Planning the new phase of BioFactors: An IUBMB journal	5
Resolvins protect against diabetes‐induced colonic oxidative stress, barrier dysfunction, and associated diarrhea via the HO‐1 pathway	5
Platelet‐activating factor as an endogenous cofactor of food anaphylaxis	5
Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update	5
Retraction	5
Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells	5
The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol	5
Docosahexaenoic acid may inhibit immune evasion of colorectal cancer cells through targeting immune checkpoint and immunomodulator genes and their controlling microRNAs	5
Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR/AKT	5
High‐fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice	5
Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of	5
Integrative multi‐omic and machine learning approach for prognostic stratification and therapeutic targeting in lung squamous cell carcinoma	5
The cardioprotective effects of hydrogen sulfide by targeting endoplasmic reticulum stress and the Nrf2 signaling pathway: A review	5
Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity	5
Issue Information	5
Issue Information	5
Platelet‐activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury	5
22‐kD growth hormone‐induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation	5
Knockdown of lncRNA TUG1 attenuates cerebral ischemia/reperfusion injury through regulating miR‐142‐3p	5
The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense	5
The in vitro and in vivo skin‐whitening activity of Ectoine through enhanced autophagy in melanocytes and keratinocytes and zebrafish model	5
Machine learning‐derived peripheral blood transcriptomic biomarkers for early lung cancer diagnosis: Unveiling tumor‐immune interaction mechanisms	5
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A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes	5
Issue Highlights	5

Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins	4
The role of NRF2 transcription factor in inflammatory skin diseases	4
Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)	4
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation	4
Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1	4
Pax‐8: Molecular biology, pathophysiology, and potential pathogenesis	4
Thyroid hormones inhibit apoptosis of macrophage induced by oxidized low‐density lipoprotein	4
Ameliorating diabetes‐induced testicular dysfunction by modulating PKC/Nrf2/Bcl‐2 signaling: Protective role of sulbutiamine	4
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Melatonin mediated activation of MAP kinase pathway may reduce DNA damage stress in plants: A review	4
Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway	4
Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects	4
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Ginger and its constituents: Role in treatment of inflammatory bowel disease	4
The influence of apigenin on cellular responses to radiation: From protection to sensitization	4
Issue Information	4
High‐fat‐induced nonalcoholic fatty liver potentiates vulnerability to and the severity of viral hepatitis in a C3H/HeN mouse model	4
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer	4
PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects	4
Topical application of gemcitabine generates microvesicle particles in human and murine skin	4
Investigating the impact of Ras‐related protein RAB7A on colon adenocarcinoma behavior and its clinical significance	3
The role of P450 enzymes in malaria and other vector‐borne infectious diseases	3
Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine	3
OSBPL10‐CNBP axis mediates hypoxia‐induced pancreatic cancer development	3
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Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome	3
Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1	3
Ginger: A complementary approach for management of cardiovascular diseases	3
Corrigendum	3
Protein kinase CK2: An emerging regulator of cellular metabolism	3
Suffruticosol A elevates osteoblast differentiation targeting BMP2‐Smad/1/5/8‐RUNX2 in pre‐osteoblasts	3
Retraction	3
Light‐activatable multifunctional paclitaxel nanoprodrug for synergistic chemo‐photodynamic therapy in liver cancer	3
Issue Highlights	3
Preface	3
Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography	3
Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion	3
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Naringenin protects swine testis cells from bisphenol A‐induced apoptosis via Keap1/Nrf2 signaling pathway	3
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Molecular modeling and in vitro studies of gedunin a potent alpha‐amylase inhibitor and alpha‐glucosidase inhibitor	3
Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat	3
Issue Information	3
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma	3
Investigate the metabolic changes in intestinal diseases by employing a 1H‐NMR‐based metabolomics approach on Caco‐2 cells treated with cedrol	3
Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP‐2/‐9 expression and activity	3
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate	3
Platelet Activating Factor (PAF): A Mediator of Inflammation	3
Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho‐associated kinase pathway	3
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The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS‐CoV‐2 infection in cultured human lung cells	3
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Issue Highlights	2
Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice	2
Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation	2
Issue Information	2
Tenascin‐C regulates migration of SOX10 tendon stem cells via integrin‐α9 for promoting patellar tendon remodeling	2
Polyphenols as modulators of pre‐established gut microbiota dysbiosis: State‐of‐the‐art	2
Plectalibertellenone A suppresses colorectal cancer cell motility and glucose metabolism by targeting TGF‐β/Smad and Wnt pathways	2
Blockade of PD‐1 and CTLA‐4: A potent immunotherapeutic approach for hepatocellular carcinoma	2
Issue Information ‐ Cover	2
Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease	2
Interactions between dietary polyphenols and aging gut microbiota: A review	2
Hsp90 inhibition protects brain endothelial cells against LPS‐induced injury	2
Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS‐mediated pathways	2
Tau, tau kinases, and tauopathies: An updated overview	2
Deciphering potential molecular mechanisms in clear cell renal cell carcinoma based on the ubiquitin‐conjugating enzyme E2 related genes: Identifying UBE2C correlates to infiltra	2
Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells	2
Issue Information ‐ Cover	2
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones	2
Integration of miRNA in exosomes and single‐cell RNA‐seq profiles in endemic osteoarthritis, Kashin–Beck disease	2
Catechol‐induced covalent modifications modulate the aggregation tendency of α‐synuclein: An in‐solution and in‐silico study	2
Mitigation of experimental ER stress and diabetes mellitus induced peripheral neuropathy by autophagy promoter, 6‐BIO	2
Salvia hispanica L. (chia) seed improves redox state and reverts extracellular matrix collagen deposition in skeletal muscle of sucrose‐rich diet‐fed rats	2
Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII	2