Biofactors

Article	Citations
Issue Information	347
Issue Information	90
Reactive oxygen species as a double‐edged sword: The role of oxidative enzymes in antitumor therapy	62
Myasthenia gravis: The pharmacological basis of traditional Chinese medicine for its clinical application	57
Attenuation of p38 MAPK/NF‐κB/TRPV1/CGRP is involved in the antinociceptive effect of hesperidin methyl chalcone and taxifolin in paclitaxel‐indu	56
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Golgi stress response: A regulatory mechanism of Golgi function	51
Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR‐Induced AMPK Activation and Glucose Uptake in L6 Myotubes	50
Formation of Plant Derived Bioactive Peptides During Simulated Gastro‐Intestinal Digestion: A Systematic Review	49
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis	48
Issue Information	47
Retraction	46
Lactate dehydrogenase A is implicated in the pathogenesis of B‐cell lymphoma through regulation of the FER signaling pathway	41
Long non‐coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR‐4673/TPX2 axis and activating Wnt/β‐catenin signaling pathway	39
Long‐Term Intake of Oleic Acid‐Rich Palm Oil Induces Obesity Without Impairing Hypothalamic Insulin Sensitivity and Redox Activity in Male Wistar Rats	37
Recent research progress of biologically active peptides	37
Issue Information ‐ Cover	33
Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development	33
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?	33
Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway	29
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia	29
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	29
N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning	28
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role ofSIRT1	27
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance	26

Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells	26
The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy	25
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,	24
Retraction	24
Correction to “Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro”	24
Berberine chloride loaded nano‐PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis	24
The possible role of the nucleoside adenosine in countering skin aging: A review	24
Deletion of NRF2 disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging	23
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis	23
Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans	22
High glucose leads to redistribution of the proteasomal system	22
Issue Information ‐ Cover	21
Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type‐1 antagonistic mechanism and alters cellular metabolism	21
Agmatine suppresses glycolysis via the PI3K/Akt/mTOR/HIF‐1α signaling pathway and improves mitochondrial function in microglia exposed to lipopolysaccharide	21
Crocetin regulates Th1/Th2 and Th17/Treg balances, nitric oxide production, and nuclear localization of NF‐κB in Th2‐provoked and norm	20
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Redox‐sensitive signaling pathways in renal cell carcinoma	20
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia	20
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma	20
Deciphering the role of Zn2+‐binding histidines from TIA‐1 on the assembly and dynamics of stress granules	18
A novel peptide derived from Haematococcus pluvialis residue balanced lipid metabolism through NHR‐49/PPARα and AAK‐2/AMPK pathways in Caenorhabdi	18
Control of Mycobacterium tuberculosis infection in the elderly: Is there a role for epigenetic reprogramming reversal?	18
Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function	18
Issue Information	17
Issue Information	17
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency	17
Deubiquitinase PSMD14 promotes tumorigenicity of glioblastoma by deubiquitinating and stabilizing β‐catenin	16
Issue Information ‐ Cover	16
Proteomic profiling of intestinal epithelial‐like cell‐derived exosomes regulated by epigallocatechin gallate	16
Issue Information ‐ Cover	16
A pilot study of the effects of crocin on high‐density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome: A randomized clinical trial	15
Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential	15
Issue Information	15
Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy	15
Maternal erythrocyte fatty acid composition as a predictive marker for pregnancy health	14
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Effects of calciprotein particles on EMT induction in an in vitro 3D‐cultured proximal tubule epithelial cell model of CKD	14
A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation	14
Erratum	14
Issue Information	13
Correction to “Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition”	13
Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway	13
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Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor p	13
SP1/CTR1‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration	13
Retraction	13
Gut microbiota contribution to selenium deficiency‐induced gut–liver inflammation	13
Echinacoside promotes collagen synthesis and survival via activation of IGF‐1 signaling to alleviate UVB‐induced dermal fibroblast photoaging	12
Navigating the immune landscape with plasma cells: A pan‐cancer signature for precision immunotherapy	12
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Harnessing tumor‐derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer	12
Insights into an indolicidin‐derived low‐toxic anti‐microbial peptide's efficacy against bacterial cells while preserving eukaryotic cell viability	12
Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context	12
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Nuclear receptor 4A1 (NR4A1) upregulated by n‐butylidenephthalide via the mitogen‐activated protein kinase (MAPK) pathway ameliorates drug‐induced gingival enlargement	12
Non‐beneficial effects of resveratrol on renal epithelial cell cultures: Implications in cell differentiation	12
Dioscin: A review on pharmacological properties and therapeutic values	12
Combinatorial effect of Apigenin‐resveratrol on white adipocyte plasticity and trans‐differentiation for activating lipid metabolism	11
Leveraging supramolecular systems in biomedical breakthroughs	11
Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high‐fat diet	11
miR‐222 exerts negative regulation on insulin signaling pathway in 3T3‐L1 adipocytes	11
UPS and Kinases—Gatekeepers of the G1/S Transition	11
Identification and validation of the TRHDE‐AS1/hsa‐miR‐449a/ADAMTS5 axis as a novel prognostic biomarker in prostate cancer	11
Retraction	11
Erratum to “Revisiting the therapeutic potential of tocotrienol”	11
Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed flavanols	11
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration	11
miR‐23b/TAB3/NF‐κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia–reperfusion in rats: The protective effect of chlorogenic acid	10
Mechanisms of cancer cell death induction by triptolide	10
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The role of LncRNA‐regulated autophagy in AKI	10
Correction to EVs Biodistribution and Antifibrotic Impact in Aged Lung Fibrosis Model	9
Issue Information	9
Therapeutic potential of phytochemicals for cystic fibrosis	9
FERM domain‐containing protein 6 exerts a tumor‐inhibiting role in thyroid cancer by antagonizing oncogenic YAP1	9
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications	9
Melatonin ameliorates trimethyltin chloride‐induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1‐Nrf2/ARE axis‐mediated pyroptosis	9
Issue Information ‐ Cover	8
Issue Information ‐ Cover	8
Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle	8
Noninvasive instrumental evaluation of coenzyme Q10 phytosome on endothelial reactivity in healthy nonsmoking young volunteers: A double‐blind, randomized, placebo‐controlled cro	8
Issue Information ‐ Cover	8
Gut Microbial Metabolite Crosstalk in Crohn's Disease: Network Pharmacology Unveils Dual‐Axis Pathogenesis and Therapeutic Targets	8
Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes	8
Issue Information ‐ Cover	8
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure‐induced cardiotoxicity in swine	8
Retraction	8
Correction to “Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography”	8
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?	8
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases	8
Resolvin D1: A key endogenous inhibitor of neuroinflammation	8
DISC1 inhibits GSK3β activity to prevent tau hyperphosphorylation under diabetic encephalopathy	8
Issue Information ‐ Cover	8
Fucosterol Promotes Browning in Mouse 3T3‐L1 Adipocytes Through HO‐1/Nrf2 and AMPK Pathways	8
Carboxylative efficacy of trans and cisMK7 and comparison with other vitamin K isomers	7
Issue Information	7
Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity	7
The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol	7
Retraction	7
Altered rich‐club organization of brain functional network in autism spectrum disorder	7
The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review	7
Issue Information	7
Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells	7
Platelet‐activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury	7
Crosstalk among miR‐29, α‐SMA, and TGFβ1/β3 in melatonin‐induced exosome (Mel‐prExo) treated human limbal mesenchymal stem cells (hLMSCs): An ins	7
Torpor‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides	7
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Machine learning‐derived peripheral blood transcriptomic biomarkers for early lung cancer diagnosis: Unveiling tumor‐immune interaction mechanisms	7
Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update	7
The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense	6
The influence of apigenin on cellular responses to radiation: From protection to sensitization	6
Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR/AKT	6
Platelet‐activating factor as an endogenous cofactor of food anaphylaxis	6
Resolvins protect against diabetes‐induced colonic oxidative stress, barrier dysfunction, and associated diarrhea via the HO‐1 pathway	6
The role of NRF2 transcription factor in inflammatory skin diseases	6
Docosahexaenoic acid may inhibit immune evasion of colorectal cancer cells through targeting immune checkpoint and immunomodulator genes and their controlling microRNAs	6
The in vitro and in vivo skin‐whitening activity of Ectoine through enhanced autophagy in melanocytes and keratinocytes and zebrafish model	6
Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of	6
A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes	6
O‐GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum	6
High‐fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice	6
22‐kD growth hormone‐induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation	6
Unlocking the Antiadipogenic Potential of Carotenoids From Galdieria phlegrea	6
Ameliorating diabetes‐induced testicular dysfunction by modulating PKC/Nrf2/Bcl‐2 signaling: Protective role of sulbutiamine	6
Planning the new phase of BioFactors: An IUBMB journal	6
Integrative multi‐omic and machine learning approach for prognostic stratification and therapeutic targeting in lung squamous cell carcinoma	6
Thyroid hormones inhibit apoptosis of macrophage induced by oxidized low‐density lipoprotein	5
Ginger and its constituents: Role in treatment of inflammatory bowel disease	5
Effect of High Hydrostatic Pressure (HHP) on the Enzymatic Hydrolysis of Fish Gelatin	5

Melatonin mediated activation of MAP kinase pathway may reduce DNA damage stress in plants: A review	5
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer	5
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation	5
Issue Highlights	5
High‐fat‐induced nonalcoholic fatty liver potentiates vulnerability to and the severity of viral hepatitis in a C3H/HeN mouse model	5
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Topical application of gemcitabine generates microvesicle particles in human and murine skin	5
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The Potential Role of Matrix Metalloproteinase in Polycystic Ovary Syndrome: Implications for Extracellular Matrix Remodeling	5
Issue Information	5
Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins	5
Correction to “Bioactive Peptides in Preterm Human Milk: Impact of Maternal Characteristics and Their Association to Neonatal Outcomes”	5
Neuroprotective Effects of SELFormer‐Selected β‐Citronellol and β‐Caryophyllene in Vagotomized Ischemic Stroke Model Through Direct Brain Protection and Gut Microbiota Modulation	5
Profiling of RUVBL2‐Induced Transcriptome Alterations Highlights a Critical Role for Chromatin Remodeling in Ovarian Cancer	5
Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway	5
Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)	5
OSBPL10‐CNBP axis mediates hypoxia‐induced pancreatic cancer development	4
Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1	4
Pax‐8: Molecular biology, pathophysiology, and potential pathogenesis	4
Investigating the impact of Ras‐related protein RAB7A on colon adenocarcinoma behavior and its clinical significance	4
Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects	4
The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS‐CoV‐2 infection in cultured human lung cells	4
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate	4
Investigate the metabolic changes in intestinal diseases by employing a 1H‐NMR‐based metabolomics approach on Caco‐2 cells treated with cedrol	4
Light‐activatable multifunctional paclitaxel nanoprodrug for synergistic chemo‐photodynamic therapy in liver cancer	4
Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat	4
Retraction	4
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Corrigendum	4
The role of P450 enzymes in malaria and other vector‐borne infectious diseases	4
PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects	4
Natural Product Daidzin Inhibits Glioma Development via Suppressing the LRP5‐Mediated GSK‐3β/c‐Myc Signaling Pathway	4
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma	4
Issue Information	4
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones	3
Issue Highlights	3
Issue Information	3
Hsp90 inhibition protects brain endothelial cells against LPS‐induced injury	3
Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP‐2/‐9 expression and activity	3
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Preface	3
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Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice	3
Pathophysiology of Endoplasmic Reticulum Stress and the Potential Role of Dexmedetomidine as a Modulator	3
Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease	3
Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation	3
Naringenin protects swine testis cells from bisphenol A‐induced apoptosis via Keap1/Nrf2 signaling pathway	3
Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion	3
Molecular modeling and in vitro studies of gedunin a potent alpha‐amylase inhibitor and alpha‐glucosidase inhibitor	3
Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1	3
Suffruticosol A elevates osteoblast differentiation targeting BMP2‐Smad/1/5/8‐RUNX2 in pre‐osteoblasts	3
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Interactions between dietary polyphenols and aging gut microbiota: A review	3
Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography	3
Integration of miRNA in exosomes and single‐cell RNA‐seq profiles in endemic osteoarthritis, Kashin–Beck disease	3
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome	3
Platelet Activating Factor (PAF): A Mediator of Inflammation	3
Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho‐associated kinase pathway	3
Protein kinase CK2: An emerging regulator of cellular metabolism	3
Salvia hispanica L. (chia) seed improves redox state and reverts extracellular matrix collagen deposition in skeletal muscle of sucrose‐rich diet‐fed rats	2
Catechol‐induced covalent modifications modulate the aggregation tendency of α‐synuclein: An in‐solution and in‐silico study	2
Issue Information ‐ Cover	2
A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β‐caryophyllene	2
Issue Information ‐ Cover	2
Lipid bilayer composition as a determinant of cancer cell sensitivity to tumoricidal protein‐lipid complexes	2
Rat brown adipose tissue thermogenic markers are modulated by estrous cycle phases and short‐term fasting	2
Issue Information	2
Blockade of PD‐1 and CTLA‐4: A potent immunotherapeutic approach for hepatocellular carcinoma	2
Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS‐mediated pathways	2
Issue Information ‐ Cover	2
Preface	2
SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80‐K307	2
The carcinogenesis of esophageal squamous cell cancer is positively regulated by USP13 through WISP1 deubiquitination	2
Plectalibertellenone A suppresses colorectal cancer cell motility and glucose metabolism by targeting TGF‐β/Smad and Wnt pathways	2
Metformin and thymoquinone co‐treatment enhance 5‐fluorouracil cytotoxicity by suppressing the PI3K/mTOR/HIF1α pathway and increasing oxidative stress in colon cancer	2
Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells	2
Mitochondria‐Targeting SIRT3 Activator Effectively Controls Bleomycin‐Induced Pulmonary Fibrosis	2
Issue Information ‐ Cover	2
Retraction	2
Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII	2
Uptake and time‐dependent subcellular localization of native and micellar curcumin in intestinal cells	2
HDL‐mediated reduction of cholesterol content inhibits the proliferation of prostate cancer cells induced by LDL: Role of ABCA1 and proteasome inhibition	2
Wnt inhibitory 1 ameliorates neovascularization and attenuates photoreceptor injury in an oxygen‐induced retinopathy mouse model	2
Mitigation of experimental ER stress and diabetes mellitus induced peripheral neuropathy by autophagy promoter, 6‐BIO	2
Tau, tau kinases, and tauopathies: An updated overview	2
Deciphering potential molecular mechanisms in clear cell renal cell carcinoma based on the ubiquitin‐conjugating enzyme E2 related genes: Identifying UBE2C correlates to infiltra	2