Biofactors

Article	Citations
Issue Information	395
Issue Information	109
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Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR ‐Induced AMPK Activation and Glucose	63
Attenuation of p38 MAPK / NF ‐ κB /	60
Formation of Plant Derived Bioactive Peptides During Simulated Gastro‐Intestinal Digestion: A Systematic Review	60
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis	58
Hydroethanolic Soy Extract Rich in Isoflavones Protects Dystrophic Mutant Mice From Oxidative Stress and Inflammation via the ROS /	56
Retraction	49
Lactate dehydrogenase A is implicated in the pathogenesis of B‐cell lymphoma through regulation of the FER signaling pathway	48
Issue Information	47
The Role of STAT3 in Cancer: From Metabolic Regulation to Therapeutic Targeting	46
Long‐Term Intake of Oleic Acid‐Rich Palm Oil Induces Obesity Without Impairing Hypothalamic Insulin Sensitivity and Redox Activity in Male Wistar Rats	38
Recent research progress of biologically active peptides	37
Long non‐coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR ‐4673/	37
Issue Information ‐ Cover	35
Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development	34
Correction to “Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro”	33
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?	30
Berberine chloride loaded nano‐ PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3	29
N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning	28
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,	28
Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway	27
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance	27
The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy	27

Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells	26
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role ofSIRT1	26
The possible role of the nucleoside adenosine in countering skin aging: A review	25
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia	25
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	24
Retraction	24
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Deletion of NRF2 disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging	23
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia	23
Issue Information ‐ Cover	23
A novel peptide derived from Haematococcus pluvialis residue balanced lipid metabolism through NHR‐49/PPARα and AAK‐2/AMPK pathways in Caenorhabdi	22
High glucose leads to redistribution of the proteasomal system	22
Crocetin regulates Th1/Th2 and Th17/Treg balances, nitric oxide production, and nuclear localization of NF‐κB in Th2‐provoked and norm	21
Deciphering the role of Zn2+‐binding histidines from TIA‐1 on the assembly and dynamics of stress granules	19
Agmatine suppresses glycolysis via the PI3K /Akt/ mTOR / HIF	19
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma	19
Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type‐1 antagonistic mechanism and alters cellular metabolism	18
Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function	18
Control of Mycobacterium tuberculosis infection in the elderly: Is there a role for epigenetic reprogramming reversal?	18
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency	17
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Proteomic profiling of intestinal epithelial‐like cell‐derived exosomes regulated by epigallocatechin gallate	16
Deubiquitinase PSMD14 promotes tumorigenicity of glioblastoma by deubiquitinating and stabilizing β‐catenin	16
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Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy	16
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Oleuropein Aglycone Modulates Oxidative Stress and Autophagy‐Related Pathways in Human Skeletal Muscle Cells	15
Maternal erythrocyte fatty acid composition as a predictive marker for pregnancy health	15
Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential	15
Issue Information	15
Corrigendum to “Fucosterol Promotes Browning in Mouse 3T3‐L1 AdipocytesThrough HO‐1/Nrf2 and AMPK Pathways”	15
A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation	14
Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway	14
Effects of calciprotein particles on EMT induction in an in vitro 3D‐cultured proximal tubule epithelial cell model of CKD	14
Gut microbiota contribution to selenium deficiency‐induced gut–liver inflammation	14
Retraction	13
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Issue Information	13
Correction to “Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition”	13
SP1/CTR1‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration	13
Non‐beneficial effects of resveratrol on renal epithelial cell cultures: Implications in cell differentiation	12
Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context	12
Navigating the immune landscape with plasma cells: A pan‐cancer signature for precision immunotherapy	12
Insights into an indolicidin‐derived low‐toxic anti‐microbial peptide's efficacy against bacterial cells while preserving eukaryotic cell viability	12
Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor p	12
Harnessing tumor‐derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer	12
Retraction	12
Echinacoside promotes collagen synthesis and survival via activation of IGF ‐1 signaling to alleviate UVB	12

Nuclear receptor 4A1 (NR4A1) upregulated by n‐butylidenephthalide via the mitogen‐activated protein kinase (MAPK) pathway ameliorates drug‐induced gingival enlargement	12
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Erratum to “Revisiting the therapeutic potential of tocotrienol”	11
UPS and Kinases—Gatekeepers of the G1/S Transition	11
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration	11
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Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high‐fat diet	11
miR‐222 exerts negative regulation on insulin signaling pathway in 3T3‐L1 adipocytes	11
Identification and validation of the TRHDE‐AS1/hsa‐miR‐449a/ADAMTS5 axis as a novel prognostic biomarker in prostate cancer	11
Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed fl	11
Combinatorial effect of Apigenin‐resveratrol on white adipocyte plasticity and trans‐differentiation for activating lipid metabolism	10
Correction to “Knockdown of Integrin β1 Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells”	10
Leveraging supramolecular systems in biomedical breakthroughs	10
The role of LncRNA‐regulated autophagy in AKI	10
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Piperlongumine Triggers Reactive Oxygen Species Driven Mitochondrial Dysfunction Leading to Apoptosis in Human Colon Cancer Cells	10
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The Function and Supramolecular Assembly of the Mitochondrial Respiratory Complexes Underlie Hypertension‐Related Stroke Susceptibility in a Model of Complex Human Disease	9
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications	9
Therapeutic potential of phytochemicals for cystic fibrosis	9
Correction to “Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography”	9
Bromelain Alleviates 3‐Nitropropionic Acid‐Induced Huntington's Disease‐Like Symptoms in Rats Through the Interplay of SIRT1 /	9
Correction to EVs Biodistribution and Antifibrotic Impact in Aged Lung Fibrosis Model	9
Issue Information ‐ Cover	9
Issue Information ‐ Cover	9
BACE1 : Biological Functions and Involvement in the Pathophysiology of Alzheimer's Disease and Other Neurological Disorders	9
miR‐23b/TAB3/NF‐κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia–reperfusion in rats: The protective effect of chlorogenic acid	9
Mechanisms of cancer cell death induction by triptolide	9
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Retraction	8
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Carboxylative efficacy of trans and cisMK7 and comparison with other vitamin K isomers	8
Torpor‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides	8
Gut Microbial Metabolite Crosstalk in Crohn's Disease: Network Pharmacology Unveils Dual‐Axis Pathogenesis and Therapeutic Targets	8
DISC1 inhibits GSK3β activity to prevent tau hyperphosphorylation under diabetic encephalopathy	8
Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle	8
Altered rich‐club organization of brain functional network in autism spectrum disorder	8
Fucosterol Promotes Browning in Mouse 3T3 ‐ L1 Adipocytes Through HO	8
Andrographolide Promotes Ferroptosis in Pancreatic Cancer via Targeting and Activating HSP90 / GPX4	8
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Resolvin D1: A key endogenous inhibitor of neuroinflammation	8
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?	8
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure‐induced cardiotoxicity in swine	7
Noninvasive instrumental evaluation of coenzyme Q10 phytosome on endothelial reactivity in healthy nonsmoking young volunteers: A double‐blind, randomized, placebo‐controlled cro	7
Crosstalk among miR‐29, α‐SMA, and TGFβ1/β3 in melatonin‐induced exosome (Mel‐prExo) treated human limbal mesenchymal stem cells (hLMSCs): An ins	7
Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes	7
Jagged1‐Fluc: A Luminescent Recombinant Protein as a Sensitive Tool for High‐Throughput Screening of Colorectal Cancer	7
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases	7
Platelet‐activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury	6
Machine learning‐derived peripheral blood transcriptomic biomarkers for early lung cancer diagnosis: Unveiling tumor‐immune interaction mechanisms	6
Retraction	6
Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update	6
Resolvins protect against diabetes‐induced colonic oxidative stress, barrier dysfunction, and associated diarrhea via the HO‐1 pathway	6
Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR / AKT	6
Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells	6
Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity	6
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Planning the new phase of BioFactors: An IUBMB journal	6
Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of	6
Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins	6
The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol	6
The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review	6
Deep Learning‐Driven Enzyme Engineering in Pichia pastoris : A Sustainable Platform for High‐Yield Nootkatone Biosynthesis	6
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Platelet‐activating factor as an endogenous cofactor of food anaphylaxis	6
The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense	6
Docosahexaenoic acid may inhibit immune evasion of colorectal cancer cells through targeting immune checkpoint and immunomodulator genes and their controlling microRNAs	6
Ameliorating diabetes‐induced testicular dysfunction by modulating PKC/Nrf2/Bcl‐2 signaling: Protective role of sulbutiamine	5
The in vitro and in vivo skin‐whitening activity of Ectoine through enhanced autophagy in melanocytes and keratinocytes and zebrafish model	5
O ‐ GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, an	5
Correction to “Bioactive Peptides in Preterm Human Milk: Impact of Maternal Characteristics and Their Association to Neonatal Outcomes”	5
Unlocking the Antiadipogenic Potential of Carotenoids From Galdieria phlegrea	5
Issue Information	5
Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1	5
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Neuroprotective Effects of SELFormer ‐Selected β‐Citronellol and β‐Caryophyllene in Vagotomized Ischemic Stroke Model Through Direct Brain Protection	5
The role of NRF2 transcription factor in inflammatory skin diseases	5

Effect of High Hydrostatic Pressure ( HHP ) on the Enzymatic Hydrolysis of Fish Gelatin	5
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation	5
Topical application of gemcitabine generates microvesicle particles in human and murine skin	5
Retraction	5
The influence of apigenin on cellular responses to radiation: From protection to sensitization	5
Integrative multi‐omic and machine learning approach for prognostic stratification and therapeutic targeting in lung squamous cell carcinoma	5
High‐fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice	5
The Potential Role of Matrix Metalloproteinase in Polycystic Ovary Syndrome: Implications for Extracellular Matrix Remodeling	5
Profiling of RUVBL2 ‐Induced Transcriptome Alterations Highlights a Critical Role for Chromatin Remodeling in Ovarian Cancer	5
Melatonin mediated activation of MAP kinase pathway may reduce DNA damage stress in plants: A review	5
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma	4
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome	4
The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS‐CoV‐2 infection in cultured human lung cells	4
Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion	4
Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1	4
Investigating the impact of Ras‐related protein RAB7A on colon adenocarcinoma behavior and its clinical significance	4
The role of P450 enzymes in malaria and other vector‐borne infectious diseases	4
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Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho‐associated kinase pathway	4
Investigate the metabolic changes in intestinal diseases by employing a 1 H	4
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Light‐activatable multifunctional paclitaxel nanoprodrug for synergistic chemo‐photodynamic therapy in liver cancer	4
Natural Product Daidzin Inhibits Glioma Development via Suppressing the LRP5‐Mediated GSK‐3β/c‐Myc Signaling Pathway	4
Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects	4
Protein kinase CK2: An emerging regulator of cellular metabolism	4
Suffruticosol A elevates osteoblast differentiation targeting BMP2‐Smad/1/5/8‐RUNX2 in pre‐osteoblasts	4
The Therapeutic Potential of Flavonols in Alzheimer's Disease: Inhibiting Amyloid‐β, Oxidative Stress, and Neuroinflammation	4
Molecular modeling and in vitro studies of gedunin a potent alpha‐amylase inhibitor and alpha‐glucosidase inhibitor	4
PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects	4
Pax‐8: Molecular biology, pathophysiology, and potential pathogenesis	4
Integration of miRNA in exosomes and single‐cell RNA‐seq profiles in endemic osteoarthritis, Kashin–Beck disease	3
Hsp90 inhibition protects brain endothelial cells against LPS‐induced injury	3
Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1	3
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate	3
Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation	3
Deciphering potential molecular mechanisms in clear cell renal cell carcinoma based on the ubiquitin‐conjugating enzyme E2 related genes: Identifying	3
Tau, tau kinases, and tauopathies: An updated overview	3
Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII	3
Issue Information ‐ Cover	3
Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography	3
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Platelet Activating Factor (PAF): A Mediator of Inflammation	3
OSBPL10‐CNBP axis mediates hypoxia‐induced pancreatic cancer development	3
A Comprehensive Insight Into the Roles of Exosomal circRNAs in Metabolic Syndrome	3
Trihydroxylated Anthocyanins Potentiate Effects of Docetaxel in Mesenchymal Triple Negative Breast Cancer Cells	3
Artificial Intelligence for Detection of Parkinson's Disease From Speech Signals—A Comprehensive Review	3
Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS	3
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Pathophysiology of Endoplasmic Reticulum Stress and the Potential Role of Dexmedetomidine as a Modulator	3
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Fingernail Mineral Profiling as a Non‐Invasive Tool to Assess Dietary and Lifestyle Factors: Results From the Cross‐Sectional Fulda NutriNAIL Study	3
Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP‐2/‐9 expression and activity	3
Salvia hispanica L. (chia) seed improves redox state and reverts extracellular matrix collagen deposition in skeletal muscle of sucrose‐rich diet‐fed rats	3
Mitochondria‐Targeting SIRT3 Activator Effectively Controls Bleomycin‐Induced Pulmonary Fibrosis	3
Catechol‐induced covalent modifications modulate the aggregation tendency of α‐synuclein: An in‐solution and in‐silico study	3
Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells	3
Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease	3
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones	3