Biofactors

Article	Citations
Issue Information	371
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Myasthenia gravis: The pharmacological basis of traditional Chinese medicine for its clinical application	58
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis	58
Formation of Plant Derived Bioactive Peptides During Simulated Gastro‐Intestinal Digestion: A Systematic Review	57
Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR‐Induced AMPK Activation and Glucose Uptake in L6 Myotubes	55
Attenuation of p38 MAPK/NF‐κB/TRPV1/CGRP is involved in the antinociceptive effect of hesperidin methyl chalcone and taxifolin in paclitaxel‐indu	54
Retraction	53
Long non‐coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR‐4673/TPX2 axis and activating Wnt/β‐catenin signaling pathway	46
Lactate dehydrogenase A is implicated in the pathogenesis of B‐cell lymphoma through regulation of the FER signaling pathway	45
Long‐Term Intake of Oleic Acid‐Rich Palm Oil Induces Obesity Without Impairing Hypothalamic Insulin Sensitivity and Redox Activity in Male Wistar Rats	43
The Role of STAT3 in Cancer: From Metabolic Regulation to Therapeutic Targeting	43
Issue Information	40
Issue Information ‐ Cover	37
Recent research progress of biologically active peptides	37
Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development	35
Correction to “Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro”	31
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	31
The possible role of the nucleoside adenosine in countering skin aging: A review	30
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?	29
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role ofSIRT1	28
The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy	27
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia	27
N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning	27

Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway	26
Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells	26
Berberine chloride loaded nano‐PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis	25
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,	25
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance	24
Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type‐1 antagonistic mechanism and alters cellular metabolism	23
Retraction	23
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Issue Information ‐ Cover	23
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia	23
High glucose leads to redistribution of the proteasomal system	22
Deciphering the role of Zn2+‐binding histidines from TIA‐1 on the assembly and dynamics of stress granules	22
Deletion of NRF2 disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging	22
Control of Mycobacterium tuberculosis infection in the elderly: Is there a role for epigenetic reprogramming reversal?	21
A novel peptide derived from Haematococcus pluvialis residue balanced lipid metabolism through NHR‐49/PPARα and AAK‐2/AMPK pathways in Caenorhabdi	21
Agmatine suppresses glycolysis via the PI3K/Akt/mTOR/HIF‐1α signaling pathway and improves mitochondrial function in microglia exposed to lipopolysaccharide	19
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis	19
Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function	19
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency	18
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma	18
Crocetin regulates Th1/Th2 and Th17/Treg balances, nitric oxide production, and nuclear localization of NF‐κB in Th2‐provoked and norm	17
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Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy	16
Issue Information ‐ Cover	16
Issue Information ‐ Cover	16
Maternal erythrocyte fatty acid composition as a predictive marker for pregnancy health	15
Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential	15
Effects of calciprotein particles on EMT induction in an in vitro 3D‐cultured proximal tubule epithelial cell model of CKD	15
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Deubiquitinase PSMD14 promotes tumorigenicity of glioblastoma by deubiquitinating and stabilizing β‐catenin	15
Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway	15
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Proteomic profiling of intestinal epithelial‐like cell‐derived exosomes regulated by epigallocatechin gallate	15
Issue Information	14
Non‐beneficial effects of resveratrol on renal epithelial cell cultures: Implications in cell differentiation	14
A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation	14
SP1/CTR1‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration	14
Gut microbiota contribution to selenium deficiency‐induced gut–liver inflammation	14
Retraction	14
Navigating the immune landscape with plasma cells: A pan‐cancer signature for precision immunotherapy	13
Correction to “Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition”	13
Harnessing tumor‐derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer	13
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Echinacoside promotes collagen synthesis and survival via activation of IGF‐1 signaling to alleviate UVB‐induced dermal fibroblast photoaging	12
Insights into an indolicidin‐derived low‐toxic anti‐microbial peptide's efficacy against bacterial cells while preserving eukaryotic cell viability	12
Retraction	12
Dioscin: A review on pharmacological properties and therapeutic values	12
Nuclear receptor 4A1 (NR4A1) upregulated by n‐butylidenephthalide via the mitogen‐activated protein kinase (MAPK) pathway ameliorates drug‐induced gingival enlargement	12
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Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context	12
Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor p	12
Erratum to “Revisiting the therapeutic potential of tocotrienol”	12
Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed flavanols	11
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Identification and validation of the TRHDE‐AS1/hsa‐miR‐449a/ADAMTS5 axis as a novel prognostic biomarker in prostate cancer	11
Combinatorial effect of Apigenin‐resveratrol on white adipocyte plasticity and trans‐differentiation for activating lipid metabolism	11
The role of LncRNA‐regulated autophagy in AKI	11
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration	11
miR‐222 exerts negative regulation on insulin signaling pathway in 3T3‐L1 adipocytes	11
UPS and Kinases—Gatekeepers of the G1/S Transition	11
Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high‐fat diet	11
Correction to EVs Biodistribution and Antifibrotic Impact in Aged Lung Fibrosis Model	10
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miR‐23b/TAB3/NF‐κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia–reperfusion in rats: The protective effect of chlorogenic acid	10
Piperlongumine Triggers Reactive Oxygen Species Driven Mitochondrial Dysfunction Leading to Apoptosis in Human Colon Cancer Cells	10
Leveraging supramolecular systems in biomedical breakthroughs	10
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Gut Microbial Metabolite Crosstalk in Crohn's Disease: Network Pharmacology Unveils Dual‐Axis Pathogenesis and Therapeutic Targets	9
Retraction	9
Mechanisms of cancer cell death induction by triptolide	9
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications	9
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?	9
Fucosterol Promotes Browning in Mouse 3T3‐L1 Adipocytes Through HO‐1/Nrf2 and AMPK Pathways	9
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Correction to “Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography”	9
Torpor‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides	9
Issue Information ‐ Cover	9
Therapeutic potential of phytochemicals for cystic fibrosis	9
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Altered rich‐club organization of brain functional network in autism spectrum disorder	8
Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes	8
Noninvasive instrumental evaluation of coenzyme Q10 phytosome on endothelial reactivity in healthy nonsmoking young volunteers: A double‐blind, randomized, placebo‐controlled cro	8
The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review	8
Issue Information ‐ Cover	8
Jagged1‐Fluc: A Luminescent Recombinant Protein as a Sensitive Tool for High‐Throughput Screening of Colorectal Cancer	8
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Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle	8
DISC1 inhibits GSK3β activity to prevent tau hyperphosphorylation under diabetic encephalopathy	8
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases	8
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure‐induced cardiotoxicity in swine	8
Crosstalk among miR‐29, α‐SMA, and TGFβ1/β3 in melatonin‐induced exosome (Mel‐prExo) treated human limbal mesenchymal stem cells (hLMSCs): An ins	7
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The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol	7
Docosahexaenoic acid may inhibit immune evasion of colorectal cancer cells through targeting immune checkpoint and immunomodulator genes and their controlling microRNAs	7
Carboxylative efficacy of trans and cisMK7 and comparison with other vitamin K isomers	7
Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity	7
Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells	7
Machine learning‐derived peripheral blood transcriptomic biomarkers for early lung cancer diagnosis: Unveiling tumor‐immune interaction mechanisms	7
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Resolvin D1: A key endogenous inhibitor of neuroinflammation	7
Platelet‐activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury	7
Retraction	7
Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of	6
High‐fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice	6
Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update	6
Ginger and its constituents: Role in treatment of inflammatory bowel disease	6
Effect of High Hydrostatic Pressure (HHP) on the Enzymatic Hydrolysis of Fish Gelatin	6
Ameliorating diabetes‐induced testicular dysfunction by modulating PKC/Nrf2/Bcl‐2 signaling: Protective role of sulbutiamine	6
22‐kD growth hormone‐induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation	6
O‐GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum	6
Planning the new phase of BioFactors: An IUBMB journal	6
Resolvins protect against diabetes‐induced colonic oxidative stress, barrier dysfunction, and associated diarrhea via the HO‐1 pathway	6
Integrative multi‐omic and machine learning approach for prognostic stratification and therapeutic targeting in lung squamous cell carcinoma	6
Correction to “Bioactive Peptides in Preterm Human Milk: Impact of Maternal Characteristics and Their Association to Neonatal Outcomes”	6
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Platelet‐activating factor as an endogenous cofactor of food anaphylaxis	6
Deep Learning‐Driven Enzyme Engineering in Pichia pastoris : A Sustainable Platform for High‐Yield Nootkatone Biosynthesis	6
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Neuroprotective Effects of SELFormer‐Selected β‐Citronellol and β‐Caryophyllene in Vagotomized Ischemic Stroke Model Through Direct Brain Protection and Gut Microbiota Modulation	6
The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense	6
Unlocking the Antiadipogenic Potential of Carotenoids From Galdieria phlegrea	5
Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR/AKT	5
Melatonin mediated activation of MAP kinase pathway may reduce DNA damage stress in plants: A review	5
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation	5
Profiling of RUVBL2‐Induced Transcriptome Alterations Highlights a Critical Role for Chromatin Remodeling in Ovarian Cancer	5
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Issue Information	5
The in vitro and in vivo skin‐whitening activity of Ectoine through enhanced autophagy in melanocytes and keratinocytes and zebrafish model	5

The Potential Role of Matrix Metalloproteinase in Polycystic Ovary Syndrome: Implications for Extracellular Matrix Remodeling	5
Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins	5
High‐fat‐induced nonalcoholic fatty liver potentiates vulnerability to and the severity of viral hepatitis in a C3H/HeN mouse model	5
Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)	5
The influence of apigenin on cellular responses to radiation: From protection to sensitization	5
The role of NRF2 transcription factor in inflammatory skin diseases	5
Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway	5
Topical application of gemcitabine generates microvesicle particles in human and murine skin	5
Thyroid hormones inhibit apoptosis of macrophage induced by oxidized low‐density lipoprotein	5
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer	5
Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat	4
Investigating the impact of Ras‐related protein RAB7A on colon adenocarcinoma behavior and its clinical significance	4
Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1	4
Issue Highlights	4
Preface	4
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome	4
The Therapeutic Potential of Flavonols in Alzheimer's Disease: Inhibiting Amyloid‐β, Oxidative Stress, and Neuroinflammation	4
Corrigendum	4
Natural Product Daidzin Inhibits Glioma Development via Suppressing the LRP5‐Mediated GSK‐3β/c‐Myc Signaling Pathway	4
Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects	4
Retraction	4
PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects	4
Pax‐8: Molecular biology, pathophysiology, and potential pathogenesis	4
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Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate	4
Protein kinase CK2: An emerging regulator of cellular metabolism	4
Naringenin protects swine testis cells from bisphenol A‐induced apoptosis via Keap1/Nrf2 signaling pathway	4
Molecular modeling and in vitro studies of gedunin a potent alpha‐amylase inhibitor and alpha‐glucosidase inhibitor	4
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma	4
The role of P450 enzymes in malaria and other vector‐borne infectious diseases	4
Light‐activatable multifunctional paclitaxel nanoprodrug for synergistic chemo‐photodynamic therapy in liver cancer	4
Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho‐associated kinase pathway	4
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Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP‐2/‐9 expression and activity	4
Suffruticosol A elevates osteoblast differentiation targeting BMP2‐Smad/1/5/8‐RUNX2 in pre‐osteoblasts	4
Investigate the metabolic changes in intestinal diseases by employing a 1H‐NMR‐based metabolomics approach on Caco‐2 cells treated with cedrol	4
Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1	4
Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells	3
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Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography	3
OSBPL10‐CNBP axis mediates hypoxia‐induced pancreatic cancer development	3
Integration of miRNA in exosomes and single‐cell RNA‐seq profiles in endemic osteoarthritis, Kashin–Beck disease	3
Deciphering potential molecular mechanisms in clear cell renal cell carcinoma based on the ubiquitin‐conjugating enzyme E2 related genes: Identifying UBE2C correlates to infiltra	3
Mitochondria‐Targeting SIRT3 Activator Effectively Controls Bleomycin‐Induced Pulmonary Fibrosis	3
Salvia hispanica L. (chia) seed improves redox state and reverts extracellular matrix collagen deposition in skeletal muscle of sucrose‐rich diet‐fed rats	3
Tau, tau kinases, and tauopathies: An updated overview	3
Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease	3
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones	3
Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion	3
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Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation	3
Catechol‐induced covalent modifications modulate the aggregation tendency of α‐synuclein: An in‐solution and in‐silico study	3
Pathophysiology of Endoplasmic Reticulum Stress and the Potential Role of Dexmedetomidine as a Modulator	3
Platelet Activating Factor (PAF): A Mediator of Inflammation	3
The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS‐CoV‐2 infection in cultured human lung cells	3
Hsp90 inhibition protects brain endothelial cells against LPS‐induced injury	3
Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS‐mediated pathways	3
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Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII	3