Biofactors

Article	Citations
Luteolin as a modulator of skin aging and inflammation	125
Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue	121
Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma	115
The role of plant‐derived natural antioxidants in reduction of oxidative stress	109
COVID‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin	101
Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive review	68
Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis	65
COVID‐19, microthromboses, inflammation, and platelet activating factor	50
Luteolin, inflammation and cancer: Special emphasis on gut microbiota	40
Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction	39
Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action	38
Targeting of the tumor microenvironment by curcumin	36
Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells	30
Ischemic stroke, obesity, and the anti‐inflammatory role of melatonin	28
Circular RNA DOCK1 downregulates microRNA‐124 to induce the growth of human thyroid cancer cell lines	28
Medicinal plants and bioactive natural compounds as inhibitors of HMG‐CoA reductase: A literature review	28
Cyanidin‐3‐O‐glucoside attenuates endothelial cell dysfunction by modulating miR‐204‐5p/SIRT1‐mediated inflammation and apoptosis	28
The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review	27
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer	27
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?	27
The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective	27
Resolvin D1 protects against sepsis‐induced cardiac injury in mice	26
Quercetin prevents cadmium chloride‐induced hepatic steatosis and fibrosis by downregulating the transcription of miR‐21	25
Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals	24
Nerolidol protects the liver against cyclophosphamide‐induced hepatic inflammation, apoptosis, and fibrosis via modulation of Nrf2, NF‐κB p65, and caspase‐3 signaling molecules in Swiss alb	24

Interactions between dietary polyphenols and aging gut microbiota: A review	23
Exosomal LINC01005 derived from oxidized low‐density lipoprotein‐treated endothelial cells regulates vascular smooth muscle cell phenotypic switch	23
Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells	23
Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF‐β1/α‐SMA/Col I and III pathway	23
Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes	23
Ginger and its constituents: Role in treatment of inflammatory bowel disease	22
Dioscin: A review on pharmacological properties and therapeutic values	22
Neuroinflammation in Alzheimer's disease and beneficial action of luteolin	21
LncRNA H19 aggravates TNF‐α‐induced inflammatory injury via TAK1 pathway in MH7A cells	21
The HIF‐1/SNHG1/miR‐199a‐3p/TFAM axis explains tumor angiogenesis and metastasis under hypoxic conditions in breast cancer	21
Promising effects of gingerol against toxins: A review article	20
A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β‐caryophyllene	20
Berberine promotes peri‐implant osteogenesis in diabetic rats by ROS‐mediated IRS‐1 pathway	20
Polyphenols as modulators of pre‐established gut microbiota dysbiosis: State‐of‐the‐art	20
Powerful anti‐inflammatory action of luteolin: Potential increase with IL‐38	19
C. elegansACAT regulates lipolysis and its related lifespan in fasting through modulation of the genes in lipolysis and insulin/IGF‐1 signaling	19
A pilot study of the effects of crocin on high‐density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome: A randomized clinical trial	19
Secondary CoQ10 deficiency, bioenergetics unbalance in disease and aging	19
Platelet Activating Factor (PAF): A Mediator of Inflammation	19
An assessment of poly (ADP‐ribose) polymerase‐1 role in normal and cancer cells	18
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,	18
The roles of melatonin on kidney injury in obese and diabetic conditions	18
Specialized proresolving mediators in infection and lung injury	18
Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine	17
Catalase deficiency induces reactive oxygen species mediated pexophagy and cell death in the liver during prolonged fasting	17
Revisiting the therapeutic potential of tocotrienol	17
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis	17
Plasmatic lipocalin‐2 levels in chronic low‐grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency	16
Analytical determinations of luteolin	16
Systemic inflammation and oxidative stress induced by inhaled paraquat in rat improved by carvacrol, possible role of PPARγ receptors	15
Anti‐neuroinflammatory effect of daidzein in human hypothalamic GnRH neurons in an in vitro membrane‐based model	15
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate	15
Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism	14
Stem cell‐based therapies for cardiac diseases: The critical role of angiogenic exosomes	14
Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1	14
Reactive oxygen species as a double‐edged sword: The role of oxidative enzymes in antitumor therapy	14
Mangiferin and organ fibrosis: A mini review	14
Ginger: A complementary approach for management of cardiovascular diseases	14
Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials	13
Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system	13
Ammonia induces autophagy via circ‐IFNLR1/miR‐2188‐5p/RNF182 axis in tracheas of chickens	13
Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA‐29a‐3p/CCNT2 axis	13
The cardioprotective effects of hydrogen sulfide by targeting endoplasmic reticulum stress and the Nrf2 signaling pathway: A review	13
Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion	13
The role of biofactors in the prevention and treatment of age‐related diseases	13
Knockdown of lncRNA TUG1 attenuates cerebral ischemia/reperfusion injury through regulating miR‐142‐3p	13
Role of luteolin in overcoming Parkinson's disease	13
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases	13
Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review	13
Luteolin supplements: All that glitters is not gold	12

BCL‐6 promotes the methylation of miR‐34a by recruiting EZH2 and upregulating CTRP9 to protect ischemic myocardial injury	12
Interleukin‐5 deletion promotes sepsis‐induced M1 macrophage differentiation, deteriorates cardiac dysfunction, and exacerbates cardiac injury via the NF‐κB p65 pathway in mice	12
Resolvin D1: A key endogenous inhibitor of neuroinflammation	12
Recent research progress of biologically active peptides	12
Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update	12
Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro	12
The role of exosomal non‐codingRNAsin aging‐related diseases	12
Circulating miR‐155, let‐7c, miR‐21, and PTEN levels in differential diagnosis and prognosis of idiopathic granulomatous mastitis and breast cancer	12
Melatonin ameliorates trimethyltin chloride‐induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1‐Nrf2/ARE axis‐mediated pyroptosis	11
Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway	11
Golgi stress response: A regulatory mechanism of Golgi function	11
Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells	11
Systematic and experimental investigations of the anti‐colorectal cancer mediated by genistein	10
miR‐23b/TAB3/NF‐κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia–reperfusion in rats: The protective effect of chlorogenic acid	10
Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans	10
Altered triglyceride glucose index and fasted serum triglyceride high‐density lipoprotein cholesterol ratio predict incidence of cardiovascular disease in the Mashhad cohort study	10
Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma	10
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?	9
Rapid and simultaneous determination of histidine metabolism intermediates in human and mouse microbiota and biomatrices	9
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome	9
Altered type I collagen networking in osteoporotic human femoral head revealed by histomorphometric and Fourier transform infrared imaging correlated analyses	9
CDCA7‐regulated inflammatory mechanism through TLR4/NF‐κB signaling pathway in stomach adenocarcinoma	9
Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat	9
A systematic review and meta‐analysis of the effect of Vitamin D‐fortified food on glycemic indices	9
LncRNA LOC100507144 acts as a novel regulator of CD44/Nanog/Sox2/miR‐302/miR‐21 axis in colorectal cancer	9
Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment	9
Biological and pharmacological activities of noscapine: Focusing on its receptors and mechanisms	8
Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial‐mesenchymal transformation in a mouse model of myocarditis	8
Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans	8
Neutrophil to lymphocyte ratio is not related to carotid atherosclerosis progression and cardiovascular events in the primary prevention of cardiovascular disease: Results from the IMPROVE	8
Berberine ameliorates neuronal AD‐like change via activating Pi3k/PGCε pathway	8
alpha‐Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis	8
Molecular basis and therapeutic potential of myostatin on bone formation and metabolism in orthopedic disease	8
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance	8
Melatonin ameliorates arsenic‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats	8
Integrated analysis of the prognostic values of RNA‐binding proteins in head and neck squamous cell carcinoma	8
Crocin attenuates inflammation of lung tissue in ovalbumin‐sensitized mice by altering the expression of endoplasmic reticulum stress markers	8
Redox‐sensitive signaling pathways in renal cell carcinoma	8
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation	8
Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity	7
Naringenin protects swine testis cells from bisphenol A‐induced apoptosis via Keap1/Nrf2 signaling pathway	7
High‐throughput profiling reveals perturbation of endoplasmic reticulum stress‐related genes in atherosclerosis induced by high‐cholesterol diet and the protective role of vitamin E	7
New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors	7
Tenascin‐C regulates migration of SOX10 tendon stem cells via integrin‐α9 for promoting patellar tendon remodeling	7
Notch1 signaling enhances collagen expression and fibrosis in mouse uterus	7
Novel roles of Tsukushi in signaling pathways and multiple disease processes	7
Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy	7
Promising influences of gingerols against metabolic syndrome: A mechanistic review	7
PDIA4, a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue	7
Carboxylative efficacy of trans and cisMK7 and comparison with other vitamin K isomers	7
Production, health‐promoting properties and characterization of bioactive peptides from cereal and legume grains	7
Reduction of senescence‐associated beta‐galactosidase activity by vitamin E in human fibroblasts depends on subjects’ age and cell passage number	7
Melatonin: A regulator of the interplay between FoxO1, miR96, and miR215 signaling to diminish the growth, survival, and metastasis of murine adenocarcinoma	6
Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis	6
Butein inhibits lipogenesis in Caenorhabditis elegans	6
Mechanisms of cancer cell death induction by triptolide	6
Luteolin: The wonder flavonoid	6
Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP‐2/‐9 expression and activity	6
Time‐based investigation of urinary metabolic markers for Type 2 diabetes: Metabolomics approach for diabetes management	6
Fisetin, a major component derived from mulberry (Morus australis Poir.) leaves, prevents vascular abnormal contraction	6
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	6
Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosine monophosphate‐activated protein kinase/nuclear factor erythroid 2‐related fact	6
Inhibition of microRNA‐27b‐3p relieves osteoarthritis pain via regulation of KDM4B‐dependent DLX5	6
A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF‐κB inhibition and Nrf2 activation	6
The dietary carcinogen PhIP activates p53‐dependent DNA damage response in the colon of CYP1A‐humanized mice	6
New transcriptome and clinical findings of platelet‐activating factor in chronic spontaneous urticaria: Pathogenic and treatment relevance	6
FAM84B acts as a tumor promoter in human glioma via affecting the Akt/GSK‐3β/β‐catenin pathway	6
Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation	5
O‐GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics‐oriented study	5
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma	5
Protein kinase G phosphorylates the Alzheimer's disease‐associated tau protein at distinct Ser/Thr sites	5
Cip2A modulates osteogenic differentiation via the ERK‐Runx2 pathway in MG63 cells	5
Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins	5
Factors determining the serum 25‐hydroxyvitamin D response to vitamin D supplementation: Data mining approach	5
Glucocorticoid receptors and their upstream epigenetic regulators in adults with steroid‐resistant nephrotic syndrome	5
Interleukin‐9 deficiency affects lipopolysaccharide‐induced macrophage‐related oxidative stress and myocardial cell apoptosis via the Nrf2 pathway both in vivo and in vitro	5
Skullcapflavone I has a potent anti‐pancreatic cancer activity by targeting miR‐23a	5
Modulation of CD36‐mediated lipid accumulation and senescence by vitamin E analogs in monocytes and macrophages	5
Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK‐3β/β‐catenin pathway	5
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones	5

Clusterin, paraoxonase 1, and myeloperoxidase alterations induce high‐density lipoproteins dysfunction and contribute to peripheral artery disease; aggravation by type 2 diabetes mellitus	5
POTEE stimulates the proliferation of pancreatic cancer by activating the PI3K/Akt/GSK‐3β/β‐catenin signaling	5
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency	5
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications	5
NRF2, a crucial modulator of skin cells protection against vitiligo, psoriasis, and cancer	5
NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products	4
Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88‐dependent acceleration of hyperlipidaemia by Gram‐positive cell wall components	4
Noninvasive instrumental evaluation of coenzyme Q10 phytosome on endothelial reactivity in healthy nonsmoking young volunteers: A double‐blind, randomized, placebo‐controlled cro	4
Melatonin mediated activation of MAP kinase pathway may reduce DNA damage stress in plants: A review	4
Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A2 activity and traditional cardiovascular risk factors	4
Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors	4
Macrophage migration inhibitory factor deficiency aggravates effects of fructose‐enriched diet on lipid metabolism in the mouse liver	4
Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review	4
Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease	4
Hsa_circ_0045714 induced by eupatilin has a potential to promote fracture healing	4
Crocetin regulates Th1/Th2 and Th17/Treg balances, nitric oxide production, and nuclear localization of NF‐κB in Th2‐provoked and norm	4
Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)	4
HDL‐mediated reduction of cholesterol content inhibits the proliferation of prostate cancer cells induced by LDL: Role of ABCA1 and proteasome inhibition	4
Uptake and time‐dependent subcellular localization of native and micellar curcumin in intestinal cells	4
Human antigen R (HuR) and Cold inducible RNA‐binding protein (CIRP) influence intestinal mucosal barrier function in ulcerative colitis by competitive regulation on Claudin1	4
Hsp90 inhibition protects brain endothelial cells against LPS‐induced injury	4
Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle	4
PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects	4
The possible role of the nucleoside adenosine in countering skin aging: A review	4
22‐kD growth hormone‐induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation	4
Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases	4
A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes	4
Nutrient‐sensing amyloid metastasis	3
Role of ferroptosis inhibitors in the management of diabetes	3
Effects of rosmarinic acid, carnosic acid, rosmanol, carnosol, and ursolic acid on the pathogenesis of respiratory diseases	3
Suffruticosol A elevates osteoblast differentiation targeting BMP2‐Smad/1/5/8‐RUNX2 in pre‐osteoblasts	3
Dicer and Drosha expression in patients with nephrotic syndrome	3
Wnt inhibitory 1 ameliorates neovascularization and attenuates photoreceptor injury in an oxygen‐induced retinopathy mouse model	3
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure‐induced cardiotoxicity in swine	3
Regulation of citrulline synthesis in human enterocytes: Role of hypoxia and inflammation	3
Application of peptide biomarkers in life analysis based on liquid chromatography–mass spectrometry technology	3
Tau, tau kinases, and tauopathies: An updated overview	3
Plasmalogens and platelet‐activating factor roles in chronic inflammatory diseases	2
Modulatory effects of point‐mutated IL‐32θ (A94V) on tumor progression in triple‐negative breast cancer cells	2
Cardiac troponins: Mechanisms of release and role in healthy and diseased subjects	2
Lnc‐hipk1 inhibits mouse adipocyte apoptosis as a sponge of miR‐497	2
Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue	2
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role of SIRT1	2
Thyroid hormones inhibit apoptosis of macrophage induced by oxidized low‐density lipoprotein	2
Nesting and fate of transplanted stem cells in hypoxic/ischemic injured tissues: The role of HIF1α/sirtuins and downstream molecular interactions	2
Shaggy functions downstream of dMyc and their concurrent downregulation confers additive rescue against tau toxicity in Drosophila	2
Celastrol attenuates high‐fructose diet‐induced inflammation and insulin resistance via inhibition of 11β‐hydroxysteroid dehydrogenase type 1 activity in rat adipose tissues	2
Maternal erythrocyte fatty acid composition as a predictive marker for pregnancy health	2
Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation	2
Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review	2
Longevity effects of hispidol in Caenorhabditis elegans	2
Topical application of gemcitabine generates microvesicle particles in human and murine skin	2
Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases	2
The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy	2
Evaluation of photostability and phototoxicity of esterified derivatives of ubiquinol‐10 and their application as prodrugs of reduced coenzyme Q10 for topical administration	2
New biomarkers and therapeutic targets of human liver cancer: Transcriptomic findings	2
Platelet‐activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury	2
The unique molecular targets associated antioxidant and antifibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach	2
Roles of circular RNAs in osteogenic/osteoclastogenic differentiation	2
Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects	2
Light‐activatable multifunctional paclitaxel nanoprodrug for synergistic chemo‐photodynamic therapy in liver cancer	2
FERM domain‐containing protein 6 exerts a tumor‐inhibiting role in thyroid cancer by antagonizing oncogenic YAP1	2
Therapeutic potential of phytochemicals for cystic fibrosis	2
Metformin and thymoquinone co‐treatment enhance 5‐fluorouracil cytotoxicity by suppressing the PI3K/mTOR/HIF1α pathway and increasing oxidative stress in colon cancer	2
Platelet activating factor: Have we been missing the forest for the trees?	2
MiR‐1471 protects the aggravation of non‐small‐cell lung carcinoma by targeting FOXL1	2