Biofactors

Article	Citations
	249
Downregulation of microRNA‐326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer	142
Bioactive peptides in preterm human milk: Impact of maternal characteristics and their association to neonatal outcomes	97
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Shaggy functions downstream of dMyc and their concurrent downregulation confers additive rescue against tau toxicity in Drosophila	48
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF‐κB signaling pathway	48
Insights into an indolicidin‐derived low‐toxic anti‐microbial peptide's efficacy against bacterial cells while preserving eukaryotic cell viability	46
The cardioprotective effects of hydrogen sulfide by targeting endoplasmic reticulum stress and the Nrf2 signaling pathway: A review	42
Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas‐mediated signaling	39
Golgi stress response: A regulatory mechanism of Golgi function	36
Vitamin D metabolism is altered during aging alone or combined with obesity in male mice	36
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Blockade of PD‐1 and CTLA‐4: A potent immunotherapeutic approach for hepatocellular carcinoma	29
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Tau, tau kinases, and tauopathies: An updated overview	29
Issue Highlights	28
α‐Asarone alleviates allergic asthma by stabilizing mast cells through inhibition of ERK/JAK2‐STAT3 pathway	27
Tenascin‐C regulates migration of SOX10 tendon stem cells via integrin‐α9 for promoting patellar tendon remodeling	26
REVERBA couples the circadian clock to Leydig cell steroidogenesis	25
Docosahexaenoic acid may inhibit immune evasion of colorectal cancer cells through targeting immune checkpoint and immunomodulator genes and their controlling microRNAs	25

Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae	24
Biochemical and cellular studies of three human 3‐phosphoglycerate dehydrogenase variants responsible for pathological reduced L‐serine levels	24
Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII	23
A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes	23
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P38α contributes to TNF‐α‐induced IL‐8 production in human gingival cells	22
Myasthenia gravis: The pharmacological basis of traditional Chinese medicine for its clinical application	22
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The functional roles of S‐adenosyl‐methionine and S‐adenosyl‐homocysteine and their involvement in trisomy 21	20
Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers	20
Celastrol attenuates high‐fructose diet‐induced inflammation and insulin resistance via inhibition of 11β‐hydroxysteroid dehydrogenase type 1 activity in rat adipose tissues	19
Deciphering potential molecular mechanisms in clear cell renal cell carcinoma based on the ubiquitin‐conjugating enzyme E2 related genes: Identifying UBE2C correlates to infiltra	19
Reactive oxygen species as a double‐edged sword: The role of oxidative enzymes in antitumor therapy	19
Endogenous chemicals guard health through inhibiting ferroptotic cell death	19
Attenuation of p38 MAPK/NF‐κB/TRPV1/CGRP is involved in the antinociceptive effect of hesperidin methyl chalcone and taxifolin in paclitaxel‐indu	18
Construction of lysosome‐related prognostic signature to predict the survival outcomes and selecting suitable drugs for patients with HNSCC	18
Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS‐mediated pathways	18
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK‐mTOR pathway in sheep associated with prolificacy	17
Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK‐3β/β‐catenin pathway	17
Human antigen R (HuR) and Cold inducible RNA‐binding protein (CIRP) influence intestinal mucosal barrier function in ulcerative colitis by competitive regulation on Claudin1	17
PON1 has palmitoyl‐protein thioesterase (PPT) activity, and can affect the presence of SR‐B1 on the endothelial cell membrane	17
Issue Highlights	17
Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor p	17
Harnessing tumor‐derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer	16
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis	16
Neuroinflammation in Alzheimer's disease and beneficial action of luteolin	16
Exploring the therapeutic potential of naturally occurring piceatannol in non‐communicable diseases	16
Catechol‐induced covalent modifications modulate the aggregation tendency of α‐synuclein: An in‐solution and in‐silico study	15
Dioscin: A review on pharmacological properties and therapeutic values	15
Salvia hispanica L. (chia) seed improves redox state and reverts extracellular matrix collagen deposition in skeletal muscle of sucrose‐rich diet‐fed rats	15
Navigating the immune landscape with plasma cells: A pan‐cancer signature for precision immunotherapy	15
Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice	14
FAM49B drives colorectal cancer progression by stabilizing c‐Myc through NEK9 phosphorylation	14
Polyphenols as modulators of pre‐established gut microbiota dysbiosis: State‐of‐the‐art	14
Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review	14
Echinacoside promotes collagen synthesis and survival via activation of IGF‐1 signaling to alleviate UVB‐induced dermal fibroblast photoaging	14
Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update	13
Caffeic acid phenethyl ester surmounts acquired resistance of AZD9291 in non‐small cell lung cancer cells	13
Correction to “Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects”	13
New biomarkers and therapeutic targets of human liver cancer: Transcriptomic findings	13
Correction to “Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition”	13
Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells	12
miR‐222 exerts negative regulation on insulin signaling pathway in 3T3‐L1 adipocytes	12
Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context	12
Retraction	12
Nuclear receptor 4A1 (NR4A1) upregulated by n‐butylidenephthalide via the mitogen‐activated protein kinase (MAPK) pathway ameliorates drug‐induced gingival enlargement	12
Retraction	12
NRF2, a crucial modulator of skin cells protection against vitiligo, psoriasis, and cancer	11
Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins	11
Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials	11

Platelet‐activating factor as an endogenous cofactor of food anaphylaxis	11
Rat brown adipose tissue thermogenic markers are modulated by estrous cycle phases and short‐term fasting	10
High‐fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice	10
Quercetin prevents cadmium chloride‐induced hepatic steatosis and fibrosis by downregulating the transcription ofmiR‐21	10
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Luteolin: The wonder flavonoid	10
A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β‐caryophyllene	10
SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80‐K307	10
Targeting stress granules in neurodegenerative diseases: A focus on biological function and dynamics disorders	10
Plectalibertellenone A suppresses colorectal cancer cell motility and glucose metabolism by targeting TGF‐β/Smad and Wnt pathways	9
Thiamine disulfide derivatives in thiol redox regulation: Role of thioredoxin and glutathione systems	9
O‐GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum	9
Integrative multi‐omic and machine learning approach for prognostic stratification and therapeutic targeting in lung squamous cell carcinoma	9
Role of miRNAs in breast cancer development and progression: Current research	9
Mitigation of experimental ER stress and diabetes mellitus induced peripheral neuropathy by autophagy promoter, 6‐BIO	9
ErbB2‐NOTCH1 axis controls autophagy in cardiac cells	9
Ameliorating diabetes‐induced testicular dysfunction by modulating PKC/Nrf2/Bcl‐2 signaling: Protective role of sulbutiamine	9
CXC chemokine receptor 4 ‐ mediated immune modulation and tumor microenvironment heterogeneity in gastric cancer: Utilizing multi‐omics approaches to identify potential therapeutic targets	9
Combinatorial effect of Apigenin‐resveratrol on white adipocyte plasticity and trans‐differentiation for activating lipid metabolism	9
The carcinogenesis of esophageal squamous cell cancer is positively regulated by USP13 through WISP1 deubiquitination	9
The influence of apigenin on cellular responses to radiation: From protection to sensitization	9
Wnt inhibitory 1 ameliorates neovascularization and attenuates photoreceptor injury in an oxygen‐induced retinopathy mouse model	8
Lactate dehydrogenase A is implicated in the pathogenesis of B‐cell lymphoma through regulation of the FER signaling pathway	8
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Identification and validation of the TRHDE‐AS1/hsa‐miR‐449a/ADAMTS5 axis as a novel prognostic biomarker in prostate cancer	8
22‐kD growth hormone‐induced nuclear GHR/STAT5/CyclinD1 signaling pathway plays an important role in promoting mesenchymal stem cell proliferation	8
Resolvins protect against diabetes‐induced colonic oxidative stress, barrier dysfunction, and associated diarrhea via the HO‐1 pathway	8
Platelet activating factor: Have we been missing the forest for the trees?	8
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Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases	8
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Lipid bilayer composition as a determinant of cancer cell sensitivity to tumoricidal protein‐lipid complexes	8
Comprehensive analysis of the value of angiogenesis and stemness‐related genes in the prognosis and immunotherapy of ovarian cancer	8
Erratum to “Revisiting the therapeutic potential of tocotrienol”	8
Planning the new phase of BioFactors: An IUBMB journal	7
Preface	7
Altered type I collagen networking in osteoporotic human femoral head revealed by histomorphometric and Fourier transform infrared imaging correlated analyses	7
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Metformin and thymoquinone co‐treatment enhance 5‐fluorouracil cytotoxicity by suppressing the PI3K/mTOR/HIF1α pathway and increasing oxidative stress in colon cancer	7
Issue Highlights	7
Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors	7
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Modulation of CD36‐mediated lipid accumulation and senescence by vitamin E analogs in monocytes and macrophages	6
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration	6
Glycosaminoglycan dermatan sulfate supplementation decreases diet‐induced obesity and metabolic dysfunction in mice	6
Long non‐coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR‐4673/TPX2 axis and activating Wnt/β‐catenin signaling pathway	6
Uptake and time‐dependent subcellular localization of native and micellar curcumin in intestinal cells	6
Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high‐fat diet	6
Insights into the antiosteoporotic mechanism of the soy‐derived isoflavone genistein: Modulation of the Wnt/beta‐catenin signaling	6
Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals	6
FAM84B acts as a tumor promoter in human glioma via affecting the Akt/GSK‐3β/β‐catenin pathway	6
HDL‐mediated reduction of cholesterol content inhibits the proliferation of prostate cancer cells induced by LDL: Role of ABCA1 and proteasome inhibition	6
Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue	5
Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed flavanols	5
The role of LncRNA‐regulated autophagy in AKI	5
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Lemon extract reduces the hepatic oxidative stress and persulfidation levels by upregulating the Nrf2 and Trx1 expression in old rats	5
CORRIGENDUM	5
Recent research progress of biologically active peptides	5
Retraction	5
Knockdown of lncRNA TUG1 attenuates cerebral ischemia/reperfusion injury through regulating miR‐142‐3p	5
Effects of rosmarinic acid, carnosic acid, rosmanol, carnosol, and ursolic acid on the pathogenesis of respiratory diseases	5
Ginger and its constituents: Role in treatment of inflammatory bowel disease	5
The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense	5
Retraction	5
Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of	5
Secondary CoQ10 deficiency, bioenergetics unbalance in disease and aging	5
Melatonin ameliorates arsenic‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats	5
Sulforaphane prevents diabetes‐induced hepatic ferroptosis by activating Nrf2 signaling axis	4
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Retraction	4
The role of exosomal non‐codingRNAsin aging‐related diseases	4
Molecular basis of progressive familial intrahepatic cholestasis 3. A proteomics study	4
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?	4
Issue Information	4
High‐fat‐induced nonalcoholic fatty liver potentiates vulnerability to and the severity of viral hepatitis in a C3H/HeN mouse model	4
Therapeutics studies and biological properties of Teucrium polium (Lamiaceae)	4
Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR/AKT	4
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Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A2 activity and traditional cardiovascular risk factors	4
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Preface	4
Retraction	4
NXNL1 negatively regulates osteoblast differentiation via GDF15‐induced PP2A Cα dependent manner in MC3T3‐E1 cells	4
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia	4
miR‐23b/TAB3/NF‐κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia–reperfusion in rats: The protective effect of chlorogenic acid	4
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The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy	4
Topical application of gemcitabine generates microvesicle particles in human and murine skin	3
High‐density lipoprotein lipid peroxidation as a diagnostics biomarker in coronary artery disease	3
The possible role of the nucleoside adenosine in countering skin aging: A review	3
Therapeutic potential of phytochemicals for cystic fibrosis	3
Issue Information ‐ Cover	3
Breast cancer diagnosis and management guided by data augmentation, utilizing an integrated framework of SHAP and random augmentation	3
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role ofSIRT1	3
Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases	3
Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway	3
Mechanisms of cancer cell death induction by triptolide	3
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications	3
Epigallocatechin‐3‐gallate attenuates arsenic‐induced fibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations and antioxidant activities	3
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance	3
Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development	3
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation	3
Neutrophil to lymphocyte ratio is not related to carotid atherosclerosis progression and cardiovascular events in the primary prevention of cardiovascular disease: Results from the IMPROVE	3
N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning	3
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FERM domain‐containing protein 6 exerts a tumor‐inhibiting role in thyroid cancer by antagonizing oncogenic YAP1	3
Dietary restriction alters insulin signaling pathway in the brain	3
Melatonin mediated activation of MAP kinase pathway may reduce DNA damage stress in plants: A review	3
Construction of mitochondrial quality regulation genes‐related prognostic model based on bulk‐RNA‐seq analysis in multiple myeloma	2
The role of plant‐derived natural antioxidants in reduction of oxidative stress	2
Astrocytic aerobic glycolysis provides lactate to support neuronal oxidative metabolism in the hippocampus	2
Issue Information ‐ Cover	2
Analytical determinations of luteolin	2
Retraction	2
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer	2
Preface	2
Rigosertib is more potent than wortmannin and rapamycin against adult T‐cell leukemia‐lymphoma	2
Involvement of metformin and aging in salivary expression of ACE2 and TMPRSS2	2
Novel enzyme‐resistant pancreatic polypeptide analogs evoke pancreatic beta‐cell rest, enhance islet cell turnover, and inhibit food intake in mice	2
Promising influences of gingerols against metabolic syndrome: A mechanistic review	2
Fisetin is a selective adenosine triphosphate‐competitive inhibitor for mitogen‐activated protein kinase kinase 4 to inhibit lipopolysaccharide‐stimulated inflammation	2
Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans	2
Delphinidin or α‐amyrin attenuated liver steatosis and metabolic disarrangement in rats fed a high‐fat diet	2
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,	2
The role of P450 enzymes in malaria and other vector‐borne infectious diseases	2
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RETRACTION: Systemic inflammation and oxidative stress induced by inhaled Paraquat in rat improved by Carvacrol, possible role of PPARγ receptors	2
Thyroid hormones inhibit apoptosis of macrophage induced by oxidized low‐density lipoprotein	2
Cip2A modulates osteogenic differentiation via the ERK‐Runx2 pathway in MG63 cells	2
Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway	2
Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells	2
Berberine chloride loaded nano‐PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis	2
Quercetin attenuates angiotensin II‐induced proliferation of vascular smooth muscle cells and p53 pathway activation in vitro and in vivo	2
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	2
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Redox‐sensitive signaling pathways in renal cell carcinoma	2
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Harnessing the ubiquitin proteasome system as a key player in stem cell biology	2
Issue Highlights	2
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Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy	1
Interleukin‐9 deficiency affects lipopolysaccharide‐induced macrophage‐related oxidative stress and myocardial cell apoptosis via the Nrf2 pathway both in vivo and in vitro	1
Harnessing the therapeutic potential of phytochemicals in neuroblastoma	1
Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1	1
Angiopoietin‐like protein 4 induces growth hormone variant secretion and aggravates insulin resistance during pregnancy, linking obesity to gestational diabetes mellitus	1
BAG3 regulates cilia homeostasis of glioblastoma via its WW domain	1
Natural product fargesin interferes with H3 histone lactylation via targeting PKM2 to inhibit non‐small cell lung cancer tumorigenesis	1
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis	1
New transcriptome and clinical findings of platelet‐activating factor in chronic spontaneous urticaria: Pathogenic and treatment relevance	1
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The HIF‐1/SNHG1/miR‐199a‐3p/TFAM axis explains tumor angiogenesis and metastasis under hypoxic conditions in breast cancer	1
Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans	1
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?	1
Quercetin and its derivatives from lotus (Nelumbo nucifera) seedpod extract combat radioresistance by suppressing ACSL4	1
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Limosilactobacillus reuteri DSM 17938 relieves inflammation, endoplasmic reticulum stress, and autophagy in hippocampus of western diet‐fed rats by modulation of systemic inflammatio	1
Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue	1
Stachydrine, N‐acetylornithine and trimethylamine N‐oxide levels as candidate milk biomarkers of maternal consumption of an obesogenic diet during lactation	1
Roles of circular RNAs in osteogenic/osteoclastogenic differentiation	1
Issue Highlights	1
Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes	1
Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA‐29a‐3p/CCNT2 axis	1
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia	1
Arsenic‐induced transition of thymic inflammation‐to‐fibrosis involves Stat3‐Twist1 interaction: Melatonin to the rescue	1
Fisetin, a major component derived from mulberry (Morus australis Poir.) leaves, prevents vascular abnormal contraction	1
Dose‐dependent effects of anthocyanin‐rich extracts on obesity‐induced inflammation and gut microbiota modulation	1
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma	1
Lnc‐hipk1 inhibits mouse adipocyte apoptosis as a sponge of miR‐497	1
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma	1