Phytotherapy Research

Article	Citations
Harnessing the Potential of Carotenoids for Cancer Therapy: An Integrated Machine Learning and MST Based Approach	155
Vegetable‐derived indole enhances the melanoma‐treating efficacy of chemotherapeutics	141
Pharmacovigilance of unlicensed cannabidiol in European countries	121
The influence of propolis plus Hyoscyamus niger L. against COVID‐19: A phase II, multicenter, placebo‐controlled, randomized trial	117
Targeting Mitochondrial Dysfunction by Natural Products for the Treatment of Diabetic Kidney Disease	91
Phytoncides could potentially inhibit the spike protein of SARS‐CoV‐2 variants	89
Issue Information	88
Curcumin and Its Protein Targets: Literature Review and Systems Biology Analysis	88
Ethanol extract of Pueraria lobata improve acute myocardial infarction in rats via regulating gut microbiota and bile acid metabolism	86
Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling	82
Unleashing the Therapeutic Power of Natural Alkaloids in Triple‐Negative Breast Cancer: State‐of‐the‐Art Advances and Future Directions	80
RETRACTION : Epigallocatechin‐3‐Gallate Enhances Differentiation of Acute Promyelocytic Leukemia Cells via Inhibition of PML	78
Piperine Improves DSS‐Induced Colitis in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota	78
Anti‐Warburg effect via generation of ROS and inhibition of PKM2/β‐catenin mediates apoptosis of lambertianic acid in prostate cancer cells	77
Phase III randomized clinical trial of BV‐4051, an Ayurvedic polyherbal formulation in moderate SARS‐CoV‐2 infections and its impact on inflammatory biomarkers	74
Saponin monomers: Potential candidates for the treatment of type 2 diabetes mellitus and its complications	71
Icaritin Sensitizes Hepatocellular Carcinoma to PD ‐ L1 Therapy by NQO1	67
Bryodulcosigenin attenuates bleomycin‐induced pulmonary fibrosis via inhibiting AMPK‐mediated mesenchymal epithelial transition and oxidative stress	64
Effects of gypenoside L‐containingGynostemma pentaphyllumextract on fatigue and physical performance: A double‐blind, placebo‐controlled, randomized trial	64
Correction to “Antiinflammatory Effects and Chemical Constituents of Veronicastrum axillare ”	64
Xanthohumol Regulates Mitophagy in Osteosarcoma Cells via AMPK‐ULK1‐FUNDC1 Signaling Pathway	62
Natural compounds as obesity pharmacotherapies	61
The effect of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis: A double‐blind, placebo, controlled randomized clinical trial	61
Schisandra B, a representative lignan from Schisandra chinensis, improves cisplatin‐induced toxicity: An in vitro study	61
Modulation of miRNAs by Phytochemicals in Cerebral Ischemia: A Systematic Review of In Vitro and In Vivo Studies	60

Harnessing Essential Oils for Acetylcholinesterase Inhibition: A Literature Review	59
Zingibroside R1 Isolated From Achyranthes bidentata Blume Ameliorates LPS/D‐GalN‐Induced Liver Injury by Regulating Succinic Acid Metabolism via the	57
Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum)	55
Efficacy of frankincense‐based herbal product in urinary incontinence: A randomized, double‐blind, placebo‐ and active‐controlled clinical trial	54
Asiatic Acid Ameliorates MNNG ‐Induced Chronic Atrophic Gastritis by Inhibiting the Activation of the HRAS	53
Antiplatelet effect of ginkgo diterpene lactone meglumine injection in acute ischemic stroke: A randomized, double‐blind, placebo‐controlled clinical trial	53
Astragalin Inhibits Oxidative Stress‐Induced Pyroptosis and Apoptosis in Mouse Models of Renal Ischemia/Reperfusion Injury by Activating the SIRT1 /N	52
Phytochemicals targeting ferroptosis in cardiovascular diseases: Recent advances and therapeutic perspectives	52
The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double‐blind, controlled trial	51
Effects of different natural products in patients with non‐alcoholic fatty liver disease—A network meta‐analysis of randomized controlled trials	50
Preclinical studies of the antitumor effect of curcumin‐loaded polymeric nanocapsules: A systematic review and meta‐analysis	48
Curcumin as a therapeutic agent in cancer therapy: Focusing on its modulatory effects on circularRNAs	47
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the	46
Ellagitannin Component Punicalin Ameliorates Cognitive Dysfunction, Oxidative Stress, and Neuroinflammation via the Inhibition of cGAS‐STING Signaling in the Brain of an Aging Mo	46
Oncopreventive and Oncotherapeutic Potential of Plant Secondary Metabolites Against Gastric Cancer: A Review	45
Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies	45
Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents	45
Issue Information	44
Protective Effects of Oxyberberine Against Hyperuricemic Nephropathy: Mechanistic Insights From In Silico, In Vitro, and In Vivo Studies	44
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4′‐Hydroxychalcone Induces Ferroptosis in Glioblastoma Through the xCT/GSH/GPX4 Axis Under the Regulation of the AKT/mTORC1/4EBP1 Path	44
Co‐administration of sub‐effective doses of the constituents of Crocus sativus L. crocins with those of the antipsychotics clozapine and risperidone counteract memory deficits caused by blockad	44
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Upregulation of key factors of viral entry of corona‐ and influenza viruses upon TLR3‐signaling in cells from the respiratory tract and clinical treatment options by 1,8‐Cineol	42
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The effects of Garcinia cambogia (hydroxycitric acid) on lipid profile: A systematic review and meta‐analysis of randomized controlled trials	41
Immunostimulant plant proteins: Potential candidates as vaccine adjuvants	41
Curcumin Alleviates Bone Cancer Pain by Inhibiting Satellite Glial Cell Activity via Janus Kinase 1/Signal Transducer and Transcription 3 Pathway Activator	41
Mechanisms and Potential of Antitumor Therapy With Natural Products Regulating Non‐Coding RNAs	40
Jatrorrhizine alleviates cytokine storm secondary lung injury via regulating CD39‐dominant purinergic braking and downstream NLRP3 inflammasome	40
Xanthohumol Alleviates Inflammatory Bowel Disease‐Associated Osteoporosis via Regulating Gut Microbial Metabolites	40
Brazilian red propolis exerts a cytotoxic action against prostate cancer cells and upregulates human monocyte functions	38
A grape (Vitis vinifera L.) pomace water extract modulates inflammatory and immune response in SW‐480 cells and isolated mouse colon	38
Exploring the therapeutic implications of natural compounds modulating apoptosis in vascular dementia	37
Ouratein D, a Biflavanone From Ouratea spectabilis, Alleviates Betacoronavirus Infection by Mitigating Inflammation, Lung Damage and Viral Replication	37
Mitochondrial‐targeted curcumin inhibits T‐cell activation via Nrf2 and inhibits graft‐versus‐host‐disease in a mouse model	36
Nootkatone alleviates rotenone‐induced Parkinson's disease symptoms through activation of the PI3K/Akt signaling pathway	36
Hyperoside prevents doxorubicin‐induced cardiotoxicity by inhibiting NOXs/ROS/NLRP3 inflammasome signaling pathway	36
Substantial Effects of Carotenoids on Skin Health: A Mechanistic Perspective	36
Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction	36
Fangchinoline abrogates growth and survival of hepatocellular carcinoma by negative regulation of c‐met/HGF and its associated downstream signaling pathways	36
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Is the mushroom Meripilus giganteus a potential cancer chemopreventive agent?	35
Bavachinin selectively modulates PPAR γ and maintains bone homeostasis in Type 2 Diabetes	35
Issue Information	35
Curcumin supplementation as a complementary and alternative medicine for COVID‐19 patients	35
SH‐PRO extract alleviates benign prostatic hyperplasia via ROS‐mediated activation of PARP/caspase 3 and inhibition of FOXO3a/AR/PSA s	35
Effects of Dietary Polyphenols on Vasculogenic Erectile Dysfunction: A Systematic Review of Pre‐Clinical Studies	35
Erucin Alleviates Cardiac Hypertrophy by Improving Mitochondrial Function via Nrf2‐Sirt3 Pathway	34
Astragaloside IV ameliorates radiation‐induced nerve cell damage by activating the BDNF/TrkB signaling pathway	34

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Formononetin attenuates cigarette smoke‐induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/C	34
Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition	34
Neuroinflammation inhibition and neuroprotective effects of purpurin, a potential anti‐AD compound, screened via network proximity and gene enrichment analyses	34
The effect of saffron (Crocus sativus L.) on glycemia, lipid profile, and antioxidant status in patients with type‐2 diabetes mellitus: A randomized placebo‐controlled trial	33
Tetrandrine Alleviates Pulmonary Fibrosis by Modulating Lung Microbiota‐Derived Metabolism and Ameliorating Alveolar Epithelial Cell Senescence	33
Peiminine regulates bone‐fat balance by canonical Wnt/β‐catenin pathway in an ovariectomized rat model	33
Trifolirhizin reduces osteoclast formation and prevents inflammatory osteolysis by inhibiting RANKL‐induced activation of NF‐κB and MAPK signaling pathways and ROS	33
Sulforaphane Attenuates PM 2.5 ‐Induced Chronic Obstructive Pulmonary Disease by Modulation of Nrf2 Activating and EGFR	33
Kaempferol Suppresses Abdominal Aortic Aneurysm Development via Modulation of Macrophage Polarization Through the STAT / TNF	33
Antitumor effect of luteolin proven by patient‐derived organoids of gastric cancer	33
Effect of walnut consumption on markers of endothelial function in adults: A systematic review and meta‐analysis of randomized controlled trials	33
Columbianadin Ameliorates Myocardial Injury by Inhibiting Autophagy Through the PI3K/Akt/mTOR Signaling Pathway in AMI Mice and Hypoxic H9c2 Cells	32
Traditional medicinal plants in the treatment of gastrointestinal parasites in humans: A systematic review and meta‐analysis of clinical and experimental evidence	32
Pterostilbene Exhibits Broad‐Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV‐A	32
miRNA, phytometabolites and disease: Connecting the dots	32
Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways	32
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Effect of sumac powder on clinical symptoms, hyperandrogenism, inflammation, blood glucose, lipid profiles in women with polycystic ovary syndrome: A double‐blind randomized clinical trial	32
Acetylshikonin Derived From Arnebia euchroma (Royle) Johnst Kills Multidrug‐Resistant Gram‐Positive Pathogens In Vitro and In Vivo	32
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol	31
Garlic‐Derived Exosomes Alleviate Intestinal Fibrosis in Crohn's Disease by Modulating PFKFB3 ‐Mediated Metabolic Reprogramming	31
Efficacy of Extracts of Oleogum Resin of Boswellia in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta‐Analysis	31
Lotusine ameliorates propionic acid‐induced autism spectrum disorder‐like behavior in mice by activating D1 dopamine receptor in medial prefrontal cortex	31
Gut microbiota, bile acids, and nature compounds	31
Eriodictyol Regulates Macrophage Polarization to Treat Rheumatoid Arthritis by Inhibiting Jumonji Domain‐Containing Protein D3 ‐Mediated Demethylatio	31
Ginkgo Flavone Aglycone Ameliorates Atherosclerosis via Inhibiting Endothelial Pyroptosis by Activating the Nrf2 Pathway	30
Resistant starch from black rice, Oryza sativaL. var. ameliorates renal inflammation, fibrosis and injury in insulin resistant rats	30
Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing	30
Cornuside, by regulating the AGEs‐RAGE‐IκBα‐ERK1/2 signaling pathway, ameliorates cognitive impairment associated with brain aging	30
Artemether Ameliorates Non‐Alcoholic Steatohepatitis by Restraining Cross‐Talk Between Lipotoxicity‐Induced Hepatic Hepatocytes and Macrophages	30
The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis	30
A randomized, double‐blind, placebo‐controlled study of Cistanche tubulosa and Ginkgo biloba extracts for the improvement of cognitive function in middle‐aged and elderly people	30
A Review on Antifungal Activity of Plant Essential Oils	30
Therapeutic effect of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves on ischemic stroke via the microbiota–gut–brain axis	30
Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling pathway	30
Withanolides: Promising candidates for cancer therapy	30
Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity	30
Curcumin and nano‐curcumin applications in psychiatric disorders	30
Effects of ginseng consumption on the biomarkers of oxidative stress: A systematic review and meta‐analysis	30
Hypoglycemic Effect of Ginsenoside Compound K Mediated by N‐Acetylserotonin Derived From Gut Microbiota	29
Phytochemicals as Modulators of NETosis : A Comprehensive Review on Their Mechanisms and Therapeutic Potential	29
Oxyimperatorin Suppresses the Pathologies of Rheumatoid Arthritis and the Growth of Synovial Organoids Through Targeting the PI3K /	29
Salvianolic Acid B Inhibits ZBP1‐Mediated PANoptosis in Mycobacterium tuberculosis‐Infected Macrophages by Targeting TNFR1	29
Natural products targeting macroautophagy signaling in hepatocellular carcinoma therapy: Recent evidence and perspectives	29
Formononetin Induces Ferroptosis in Activated Hepatic Stellate Cells to Attenuate Liver Fibrosis by Targeting NADPH Oxidase 4	29
Formononetin From Sophora flavescens Aiton Alleviates Atopic Dermatitis by Suppressing Neutrophil Extracellular Traps	28
A Comparison of British and US Pharmacopoeia Standards for Quality of Ashwagandha Dietary Supplements in Commerce	28
Ginsenoside Compound K Mitigates Mitochondrial Fission Through Bile Acid Receptors/YAP Signaling to Counteract Podocyte Injury in Lupus Nephritis	28
Curcumin suppressed the proliferation and apoptosis of HPV‐positive cervical cancer cells by directly targeting the E6 protein	28
Tanshinone IIA improves contextual fear‐ and anxiety‐like behaviors in mice via the CREB/BDNF/TrkB signaling pathway	28
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Behavioral and Neuroprotective Properties of the Phytoestrogen 8‐Prenylnaringenin (8‐PN) in Ovariectomized Mice	28
Bioactive Sphingolipids of Cordyceps sinensis Modulate Tumor Immunity Through the SphK1 ‐Mediated Cer/	28
Taxifolin‐mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid‐induced osteonecrosis of the femoral head	28
A Systematic Review and Meta‐Analysis of Randomized Controlled Trials on the Impact of Resveratrol Supplementation on Anthropometric Indices in Patients With Type 2 Diabetes	28
Systematic Review and Network Meta‐Analysis of the Effects of Plant Extracts on Cognitive Function and Quality of Life in Stroke Patients	28
Potato protease inhibitor II prevents obesity by inducing browning of white adipose tissue in mice via β3 adrenergic receptor signaling pathway	28
Astragaloside IV Exhibited Antidiabetic Effects by Improving Glucose Metabolism, Repairing Damaged Gut Barrier and Regulating Intestinal Microbiota	28
Germacrone alleviates breast cancer‐associated osteolysis by inhibiting osteoclastogenesis via inhibition of MAPK/NF‐κB signaling pathways	28
Phytochemicals in MASLD : A Focused Review of Gut Microbiome‐Linked Mechanisms	27
Unlocking the Therapeutic Potential of Autophagy Modulation by Natural Products in Tackling Non‐Alcoholic Fatty Liver Disease	27
Saikosaponin D Alleviates Liver Ischemia–Reperfusion Injury by Inhibiting Mitophagy‐Associated Ferroptosis via the STAT3 / P	27
Combination of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos improves cardiac function of diabetic cardiomyopathy mice by regulating the unfolded protein response signaling pathway	27
Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12‐month, randomized, double‐blind, placebo‐controlled trial	27
Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4‐ankyrin repeat domain	27
Effects of adjuvant berberine therapy on acute ischemic stroke: A meta‐analysis	27
Sinigrin Selectively Mitigates the Acute‐Cardiac Inflammatory Response Through an AMPK‐Dependent Mechanism	27
Isoliquiritigenin Exhibits Anti‐Inflammatory Responses in Acute Lung Injury by Covalently Binding to the Myeloid Differentiation Protein‐2 Domain	27
Effects of Sumac Supplementation on Lipid Profile: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials	27
Unlocking the Potential of Phyllanthus Species From Traditional Knowledge to Clinical Trials: An Updated Review of Metabolomics Approach in Diabetes Inte	27
Celastrol Suppresses SHH‐MB Growth via ROS‐Induced Stress: Evidence From In Vitro and In Vivo Studies	27
Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis	27
Total flavonoids of Rhizoma drynariae promote angiogenesis and osteogenesis in bone defects	27
The effects of flavonoids in experimental sepsis: A systematic review and meta‐analysis	27
Reniformin A Suppresses Triple‐Negative Breast Cancer Progression by Inducing DRP1‐Mediated Mitochondrial Dysfunction and Apoptosis	27
Bavachinin Suppresses the Growth of Melanoma Cells by eEF2K / eEF2 Signaling and Induces Autophagy	27
Betulin Protects Against Cardiac Hypertrophy by Improving AMPK /Nrf2‐Dependent Mitochondrial Function	26
Mechanism Study on Liquiritin Alleviating Nociceptive Sensitization in Knee Osteoarthritis via Promoting M2 Macrophage Polarization Through Regulatio	26
Protective effects of 4‐geranyloxy‐2,6‐dihydroxybenzophenonel on DSS‐induced ulcerative colitis in mice via regulation of cAMP/PKA/CREB and NF‐κB	26

Phytosomes as a New Frontier and Emerging Nanotechnology Platform for Phytopharmaceuticals: Therapeutic and Clinical Applications	26
Ursolic acid inhibits the activation of smoothened‐independent non‐canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade	26
A review on phytoestrogens: Current status and future direction	26
The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled c	26
Harnessing Dietary Phytochemicals to Modulate Signaling Pathways in Cancer Chemoprevention—A Review	26
Efficacy and Safety of Curcumin as an Adjuvant to Standard Chemotherapy in Advanced and Metastatic Breast Cancer Patients: A Randomized Controlled Study	26
MicroRNAs for Diabetes Management: From Natural Bioactive Compounds to Nucleotide Networks	26
Salidroside improves blood–brain barrier integrity and cognitive function in hypobaric hypoxia mice by inhibiting microglia activation through GSK3β	26
Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease	26
Honokiol inhibits epithelial–mesenchymal transition and hepatic fibrosis via activation of Ecadherin/GSK3β/JNK and inhibition of AKT/ERK/p38/β‐catenin/	25
Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats	25
Cancer metabolism control by natural products: Pyruvate kinase M2 targeting therapeutics	25
Medicinal herbs consumption in relation to cardiometabolic indices and coronary artery stenosis in participants undergoing coronary angiography: A cross‐sectional study	25
Isoferulic Acid Mitigates Acute Lung Injury Induced by Sepsis Through the Inhibition of JAK2	25
The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress	25
Molecular dynamics simulation and in vitro evaluation of herb–drug interactions involving dietary polyphenols and CDK inhibitors in breast cancer chemotherapy	25
Hepatoprotective effect of dietary pterostilbene against high‐fat‐diet‐induced lipid accumulation exacerbated by chronic jet lag via SIRT1 and SIRT3 activation	25
The SLCO4A1‐Mediated Transmembrane Transport of Lysionotin Attenuates Acute Lung Injury Through Activating the AMPK/Nrf2 Signaling Pathway	25
Thymol inTrachyspermum ammiseed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine‐induced Alzheimer's disease mouse model	25
Ameliorative effect ofLuffa cylindricafruits onCaenorhabditis elegansand cellular models of Alzheimer's disease‐related pathology via autophagy induction	25
Integrated Microbiome and Metabolomic to Explore the Mechanism of Coptisine in Alleviating Ulcerative Colitis	25
Potential use of curcumin against methicillin‐resistant Staphylococcus infection	25
Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis	25
Maslinic Acid Ameliorates DSS‐Induced Experimental Colitis by Suppressing Th Cell‐Mediated Inflammation via AICD Induction	25
Potential mechanism of oral baicalin treating psoriasis via suppressing Wnt signaling pathway and inhibiting Th17/IL‐17 axis by activating PPARγ	25
Plant‐derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use	25
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Effects of sea buckthorn (Hippophae rhamnoides L.) on factors related to metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trial	25
Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice	24
Glycyrrhizic Acid Alleviates Osimertinib‐Induced Cutaneous Toxicity by Inhibiting Keratinocyte Apoptosis and Inflammation	24
Poncirus trifoliata Extract and Its Active Coumarins Alleviate Dexamethasone‐Induced Skeletal Muscle Atrophy by Regulating Protein Synthesis, Mitochondrial Biogenesis, and Gut Microb	24
Paeoniflorin‐6′‐O‐benzene sulfonate protected the intestinal epithelial barrier by restoring the inhibitory effect of GRK2 and β‐arrestin 2 on ERK1/2‐NF‐κB	24
A comprehensive review of antitumor properties of Angelica species and their antitumor‐responsible constituents and the underlying molecular mechanisms involved in tumor inhibition	24
Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta‐analysis of the clinical trials	24
Icariin Inhibits NF ‐ κB Signaling in Asthmatic Lung Epithelium by Promoting Nrf2 Signaling	24
Activation of MTCH2 by Momordin Ic Prevents Colitis and Colitis‐Associated Colorectal Cancer Through Rescuing the Mitochondrial Dysfunction of Macrop	24
A Marine‐Derived Small Molecule Inhibits Prostate Cancer Growth by Promoting Endoplasmic Reticulum Stress Induced Apoptosis and Autophagy	24
Yerba mate (Ilex paraguariensis A. St.‐Hil.) for new therapeutic and nutraceutical interventions: A review of patents issued in the last 20 years (2000–2020)	24
Morroniside Modulates Microglia Polarization via the CX3CL1/CX3CR1/PU.1 Axis in ApoE4 Transgenic Mice	24
Berberine Reduces Atrial Lipotoxicity and Endoplasmic Reticulum Stress to Alleviate Heart Failure With Preserved Ejection Fraction ( HFpEF )‐Associat	23
Targeting Programmed Cell Death in Myocardial Ischemia–Reperfusion Injury: Potential Mechanisms and Natural Medicine Treatments	23
Tussilagone ameliorates high‐fat diet‐induced hepatic steatosis by enhancing energy metabolism and antioxidant activity	23
Punicalagin Alleviates Acute Liver Injury via Dual STAT1 / NF ‐ κB	23
Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double‐blind clinic	23
The role of natural products as PCSK9 modulators: A review	23
Protective Effect of Flavonoids in Ulcerative Colitis: A Systematic Review and Meta‐Analysis of Preclinical Studies	23
Morin: A Comprehensive Review of Its Sources, Nutraceutical Prospects, Chemistry, and Pharmacological Insights	23
The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/AKT signaling pathway	23
Cannabidiol tempers alcohol intake and neuroendocrine and behavioural correlates in alcohol binge drinking  adolescent rats. Focus on calcitonin gene‐related peptide's brain levels	23
Natural Compounds Exert Anti‐Obesity Effects by Regulating Cytokines	23
Moringa oleiferaLam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies	23
Effect of Puerarin on Chronic Alcoholic Encephalopathy by Modulating the “Microbiota‐Gut‐Brain Axis” Lipopolysaccharides/Toll‐Like Receptors 4/Nuclear Factor Kappa‐B Inflammatory Pathway	23
Anticancer and chemopreventive potential of Morinda citrifolia L. bioactive compounds: A comprehensive update	23
Naringin protects against inflammation and apoptosis induced by intestinal ischemia–reperfusion injury through deactivation of cGAS‐STING signaling pathway	23
Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ ‐ ATF3 ‐Gpx4 Sign	23
Plumbagin Alleviates Mild Traumatic Brain Injury‐Induced Obsessive‐Compulsive Disorder in Mice by Inhibiting nNOS and Augmenting Cortico‐Striatal Ser	23
Kaempferol's potential effects againstSARS‐CoV‐2 andCOVID‐19‐associated cancer progression and chemo‐resistance	22
Anti‐inflammatory effect of dictamnine on allergic rhinitis via suppression of the LYN kinase‐mediated molecular signaling pathway during mast cell activation	22
Curdione inhibits ferroptosis in isoprenaline‐induced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway	22
Issue Information	22
Comparing the activity of propolis‐loaded nanoparticles or hydroethanolic extract on cytokine production by peripheral blood mononuclear cells	22
Quercetin as a cancer chemopreventive or chemotherapeutic agent: Where we stand	22
In vitro characterization of iridoid and phenylethanoid glycosides from Cistanche phelypaea for nutraceutical and pharmacological applications	22
The therapeutic potential of typical plant‐derived compounds for the management of metabolic disorders	22
Antcin A, a phytosterol regulates SARS‐CoV‐2 spike protein‐mediated metabolic alteration in THP‐1 cells explored by the 1H‐NMR‐based metabolomics approach	22
Proteomic and metabolomic approaches elucidate the molecular mechanism of emodin against neuropathic pain through modulating the gamma‐aminobutyric acid (GABA)‐ergic pathway and PI3K	22
Genistein Ameliorates the Ischemic State of Random Skin Flap by Regulating Macrophage Polarization Through AMPK / SIRT1	22
Advances in Research on Marine Natural Products for Modulating the Inflammatory Microenvironment	22
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Issue Information	22
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A Prospective, Randomized, Double‐Blind, Placebo‐Controlled Clinical Study of Efficacy and Safety of Ashwagandha Root Extract Capsule on Skin and Hair Health in Healthy Adults	22
Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents	21
Green tea extract ameliorates macrophage‐driven emphysematous lesions in chronic obstructive pulmonary disease induced by cigarette smoke condensate	21
A Comprehensive Review of Biologically Active Natural Products on Human Papillomavirus (HPV) at a Glance	21
Hesperidin reduces systolic blood pressure in diabetic patients and has no effect on blood pressure in healthy individuals: A systematic review and meta‐analysis	21
Quercetin prevented diabetic nephropathy by inhibiting renal tubular epithelial cell apoptosis via the PI3K/AKT pathway	21
Ginger polysaccharide promotes myeloid‐derived suppressor cell apoptosis by regulating lipid metabolism	21
Aqueous extract ofCeratonia siliquaL. leaves elicits antioxidant, anti‐inflammatory, andAChEinhibiting effects in amyloid‐β42‐induced cognitive deficit mice: Role ofα7‐nAChR	21
Poricoic Acid A, an Active Ingredient Extracted From Poria cocos, Inhibits Lung Cancer Cell Growth by Suppressing MEK/ERK Signaling Pathway	21
Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima‐Media Thickness and Their Association With Cognitive Function in Aging and Neurodegenerat	21
Rutaecarpine Attenuates Hepatic Lipid Accumulation and Oxidative Stress by Activating Autophagy Through the AMPK / ULK1	21
Neurological recovery and neurogenesis by curcumin sustained‐release system cross‐linked with an acellular spinal cord scaffold in rat spinal cord injury: TargetingNLRP3inflammasome pathway	21
Sulforaphene‐Enriched Raphanus sativus L. Seed Extract Promotes Norepinephrine‐Induced Thermogenesis and Weight Loss by Modulating the Interplay Between	21
The effects of Capsicum annuum supplementation on lipid profiles in adults with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized controlled trials	21
Icariin, a phytoestrogen, exerts rapid estrogenic actions through crosstalk of estrogen receptors in osteoblasts	21
Curcumin: A Potential Detoxifier Against Chemical and Natural Toxicants	21
Fisetin attenuates doxorubicin‐induced cardiotoxicity by inhibiting the insulin‐like growth factor II receptor apoptotic pathway through estrogen receptor‐α/‐β activation	21
Alpinetin alleviates osteoporosis by promoting osteogenic differentiation in BMSCs by triggering autophagy via PKA/mTOR/ULK1 signaling	21
Propolis as an adjunctive therapy for treatment of uncomplicated cystitis in women: A randomized double‐blind placebo‐controlled trial	20
Efficacy of herbal treatments for functional dyspepsia: Meta‐analyses after subgroup reclassification	20
The effect of saffron supplementation on glycemic parameters: An overview of systematic reviews	20
Phytotherapy for Obesity Management: The Role of Gut Microbiota in Reshaping Adipose Tissue	20
Issue Information	20
An adventure from a work in progress: Challenges and opportunities of pharmacophylogeny in combat against COVID‐19	20