(The TQCC of Oncogene is 48. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-06-01 to 2023-06-01.)
P-glycoprotein: from genomics to mechanism793
Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells750
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention731
Toxic proteins released from mitochondria in cell death648
Isolation of cancer stem cells from adult glioblastoma multiforme632
β-Catenin destruction complex: insights and questions from a structural perspective470
Integrating signals from RTKs to ERK/MAPK437
From receptors to stress-activated MAP kinases414
The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting379
Epstein–Barr virus and oncogenesis: from latent genes to tumours379
eIF4E – from translation to transformation356
CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells294
Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours293
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death289
Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus287
High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation248
DNA double strand break repair and chromosomal translocation: Lessons from animal models246
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network227
Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells225
Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes219
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies215
Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7212
Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players209
Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients206
The ERK and JNK pathways in the regulation of metabolic reprogramming200
Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer198
Cell growth control by G protein-coupled receptors: from signal transduction to signal integration197
Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients195
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells191
Caspase activation – stepping on the gas or releasing the brakes? Lessons from humans and flies187
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis186
Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice185
From Src Homology domains to other signaling modules: proposal of the `protein recognition code'181
Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice179
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK177
Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis175
Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways167
Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift163
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)163
Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation162
Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment158
Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions157
RETRACTED ARTICLE: E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage157
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer154
Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer151
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer151
Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma149
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase148
YAP1-induced MALAT1 promotes epithelial–mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer145
Control of MAPK signalling: from complexity to what really matters142
Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor141
From Tpr-Met to Met, tumorigenesis and tubes135
BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability134
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors134
Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles133
Development of melanocyte precursors from the vertebrate neural crest133
Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1132
Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2–p12.1132
The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter130
Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1129
Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis129
Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors126
Epstein–Barr virus infection in humans: from harmless to life endangering virus–lymphocyte interactions125
Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes124
Characterization of mammary tumors from Brg1 heterozygous mice124
Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI124
Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria124
MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer122
Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis120
Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance119
Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer118
Lessons learned from BRCA1 and BRCA2118
Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10117
Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation117
New insights into cell cycle control from the Drosophila endocycle117
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin–TGFβ signaling115
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient115
WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer115
In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A114
KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner113
The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment113
Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance113
Direct cancer tissue proteomics: a method to identify candidate cancer biomarkers from formalin-fixed paraffin-embedded archival tissues112
Drosophila AP-1: lessons from an invertebrate111
ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival110
Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis110
An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment110
Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade109
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition108
Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer108
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell – cell contacts107
p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage106
Connexins in cancer: bridging the gap to the clinic105
Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer105
Microenvironmental oxygen pressure orchestrates an anti- and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes105
IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma104
Regulation of angiogenesis: apoptotic cues from the ECM103
Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24103
Extracellular vesicles swarm the cancer microenvironment: from tumor–stroma communication to drug intervention103
p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-κB activity and Fas expression102
CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation101
Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis101
Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway100
Radiation carcinogenesis: lessons from Chernobyl99
Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling98
Males absent on the first (MOF): from flies to humans98
Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-κB and Myc/Max98
Breast cancer metastases are molecularly distinct from their primary tumors97
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells97
A Sox2–Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells95
Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target95
Exosome-mediated transfer of lncRUNX2-AS1 from multiple myeloma cells to MSCs contributes to osteogenesis95
The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells95
Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein – Barr virus94
Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer94
Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis93
circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer93
Proteomic analysis reveals successive aberrations in protein expression from healthy mucosa to invasive head and neck cancer92
From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents92
Identification of radiation-specific responses from gene expression profile92
Drug methylation in cancer therapy: lessons from the TPMT polymorphism92
p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells91
Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions91
Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor91
BCR/ABL: from molecular mechanisms of leukemia induction to treatment of chronic myelogenous leukemia91
Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon91
The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs90
Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex90
Circulating cell-free DNA in breast cancer: size profiling, levels, and methylation patterns lead to prognostic and predictive classifiers90
Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae89
Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p5389
Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma89
The role of translation in neoplastic transformation from a pathologist's point of view89
Jak2 inhibition deactivates Lyn kinase through the SET–PP2A–SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients88
NF-κB-dependent MnSOD expression protects adenocarcinoma cells from TNF-α-induced apoptosis88
Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors88
The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP187
Rho GTPases in cancer: friend or foe?87
SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond86
miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer86
Mitochondrial fission causes cisplatin resistance under hypoxic conditions via ROS in ovarian cancer cells85
Induction of heat shock proteins by heregulin β1 leads to protection from apoptosis and anchorage-independent growth85
Neurotransmitters: emerging targets in cancer85
Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients84
Long-term tumor-free survival from treatment with the GFP–TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells84
LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P83
piRNA-823 delivered by multiple myeloma-derived extracellular vesicles promoted tumorigenesis through re-educating endothelial cells in the tumor environment83
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition83
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors82
Apoptotic cues from the extracellular matrix: regulators of angiogenesis82
BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo82
Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer82
G-proteins in growth and apoptosis: lessons from the heart82
Tumour exosomes from cells harbouring PTPRZ1–MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma81
YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage80
RGD peptides released from βig-h3, a TGF-β-induced cell-adhesive molecule, mediate apoptosis80
Induction of cells with cancer stem cell properties from nontumorigenic human mammary epithelial cells by defined reprogramming factors80
Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-180
Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions79
Wild-type blocking polymerase chain reaction for detection of single nucleotide minority mutations from clinical specimens79
Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression79
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo78
Heat-shock proteins: chaperoning DNA repair77
Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors77
mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p5376
The unexpected role of lymphotoxin β receptor signaling in carcinogenesis: from lymphoid tissue formation to liver and prostate cancer development76
STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells76
Epstein-Barr virus EBNA3C can disrupt multiple cell cycle checkpoints and induce nuclear division divorced from cytokinesis76
miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT75
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 474
Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control74
Hsa_circ_0001361 promotes bladder cancer invasion and metastasis through miR-491-5p/MMP9 axis74
A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene74
Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-κB but is related to downregulation of initiator caspases and DR473
Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties through adipsin73
Characterization of p53 oligomerization domain mutations isolated from Li–Fraumeni and Li–Fraumeni like family members73
Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles72
Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis72
MicroRNA-mediated breast cancer metastasis: from primary site to distant organs72
The UVB-induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes72
A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer71
NUDT21 regulates circRNA cyclization and ceRNA crosstalk in hepatocellular carcinoma71
Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis71
Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca2+/PI3K/AKT pathway71
ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts71
Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-12871
MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells71
Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL71
Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis70
miR-34c may protect lung cancer cells from paclitaxel-induced apoptosis70
Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin69
Ovarian cancer ascites protects from TRAIL-induced cell death through αvβ5 integrin-mediated focal adhesion kinase and Akt activation69
The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family69
Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-β pathway69
Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation68
Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts68
EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin68
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration68
Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis68
Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer67
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma67
A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes67
Eph receptor signalling: from catalytic to non-catalytic functions67
ATF-2 controls transcription of Maspin and GADD45α genes independently from p53 to suppress mammary tumors67
Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer66
The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance66
Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway66
PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor66
O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit66
Gz signaling: emerging divergence from Gi signaling66
Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis65
Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma65
Long non-coding RNA NONHSAT101069 promotes epirubicin resistance, migration, and invasion of breast cancer cells through NONHSAT101069/miR-129-5p/Twist1 axis64
A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome64
Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer63
Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin63
ASPM promotes prostate cancer stemness and progression by augmenting Wnt−Dvl-3−β-catenin signaling62
EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis62
Tissue necrosis and its role in cancer progression62
Hsa_circ_101555 functions as a competing endogenous RNA of miR-597-5p to promote colorectal cancer progression62
Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers62
HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells62
Type I and type II reactions in TRAIL-induced apoptosis – results from dose–response studies61
Linc00173 promotes chemoresistance and progression of small cell lung cancer by sponging miR-218 to regulate Etk expression61
Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities61
Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis61
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma61
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis61
Apolipoprotein C-1 maintains cell survival by preventing from apoptosis in pancreatic cancer cells60
NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer60
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD260
An HER3-targeting antibody–drug conjugate incorporating a DNA topoisomerase I inhibitor U3-1402 conquers EGFR tyrosine kinase inhibitor-resistant NSCLC59
The E7 protein from human papillomavirus type 16 enhances keratinocyte migration in an Akt-dependent manner59
A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI159
Base excision repair regulates PD-L1 expression in cancer cells59
Unbalanced YAP–SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma59
EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene59
Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cells58
Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein58
Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets58
MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer58
The miR-186-3p/EREG axis orchestrates tamoxifen resistance and aerobic glycolysis in breast cancer cells58
Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells58
Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence58
EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids57
The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress57
Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion57
Secondary peripheral chondrosarcoma evolving from osteochondroma as a result of outgrowth of cells with functional EXT57
Notch3: from subtle structural differences to functional diversity57
IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma57
Establishment of a monkey kidney epithelial cell line with the BARF1 open reading frame from Epstein-Barr Virus57
Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis57
KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC56
Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases56
Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Cι-mediated attenuation of p38 MAP kinase signaling56
B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis56
BCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlations56
Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer55
Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase55
The lncRNA BORG facilitates the survival and chemoresistance of triple-negative breast cancers55
AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation55
Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum55
How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc4255
Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding54
The molecular and cell biology of pediatric low-grade gliomas54
Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis54
Does the reservoir for self-renewal stem from the ends?54
Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway54
Bclaf1 promotes angiogenesis by regulating HIF-1α transcription in hepatocellular carcinoma54
Circular RNA profile identifies circOSBPL10 as an oncogenic factor and prognostic marker in gastric cancer54
Binding of human papillomavirus 16 E5 to the 16 kDa subunit c (proteolipid) of the vacuolar H+-ATPase can be dissociated from the E5-mediated epidermal growth factor receptor overactivation53
Exosome-derived miR-339-5p mediates radiosensitivity by targeting Cdc25A in locally advanced esophageal squamous cell carcinoma53
Targeting the FANCJ–BRCA1 interaction promotes a switch from recombination to polη-dependent bypass53
MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway53
Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells53
Mesenchymal cells generated from patients with myelodysplastic syndromes are devoid of chromosomal clonal markers and support short- and long-term hematopoiesis in vitro52
ERBB3 mutations in cancer: biological aspects, prevalence and therapeutics52
Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma52
Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma52
Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance52
Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site52
Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis52
Nodal-dependant Cripto signaling in ES cells: from stem cells to tumor biology52
Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice51
IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells51
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling51
The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis51
Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma51
Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo51
LCE: an open web portal to explore gene expression and clinical associations in lung cancer51
Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality50
Targeting colon cancer with the novel STAT3 inhibitor bruceantinol50
Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch150
Complementing mutations in core binding factor leukemias: from mouse models to clinical applications50
USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis50
Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics49
Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A49
TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis49
The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis49
Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size49
Dexamethasone-mediated protection from drug cytotoxicity: association with p21WAF1/CIP1 protein accumulation?49
TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment49
In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter49
Oncogenic microRNA-411 promotes lung carcinogenesis by directly targeting suppressor genes SPRY4 and TXNIP49
Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis49
MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target48
Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment48
Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis48
R-Ras is regulated by activators and effectors distinct from those that control Ras function48
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma48
Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines48
Adipose stromal cell targeting suppresses prostate cancer epithelial-mesenchymal transition and chemoresistance48
A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein48
The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation48
TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance48
Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner48
Hsp90ab1 stabilizes LRP5 to promote epithelial–mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression48
A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating cells isolated from a Brca1-associated mouse model of breast cancer48
Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells48
Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death48