Oncogene

Article	Citations
P-glycoprotein: from genomics to mechanism	793
Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells	750
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention	731
Toxic proteins released from mitochondria in cell death	648
Isolation of cancer stem cells from adult glioblastoma multiforme	632
β-Catenin destruction complex: insights and questions from a structural perspective	470
Integrating signals from RTKs to ERK/MAPK	437
From receptors to stress-activated MAP kinases	414
The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting	379
Epstein–Barr virus and oncogenesis: from latent genes to tumours	379
eIF4E – from translation to transformation	356
CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells	294
Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours	293
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death	289
Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus	287
High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation	248
DNA double strand break repair and chromosomal translocation: Lessons from animal models	246
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network	227
Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells	225
Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes	219
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies	215
Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7	212
Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players	209
Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients	206
The ERK and JNK pathways in the regulation of metabolic reprogramming	200

Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer	198
Cell growth control by G protein-coupled receptors: from signal transduction to signal integration	197
Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients	195
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells	191
Caspase activation – stepping on the gas or releasing the brakes? Lessons from humans and flies	187
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis	186
Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice	185
From Src Homology domains to other signaling modules: proposal of the `protein recognition code'	181
Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice	179
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK	177
Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis	175
Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways	167
Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift	163
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)	163
Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation	162
Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment	158
Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions	157
RETRACTED ARTICLE: E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage	157
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer	154
Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer	151
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer	151
Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma	149
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase	148
YAP1-induced MALAT1 promotes epithelial–mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer	145
Control of MAPK signalling: from complexity to what really matters	142
Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor	141
From Tpr-Met to Met, tumorigenesis and tubes	135
BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability	134
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors	134
Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles	133
Development of melanocyte precursors from the vertebrate neural crest	133
Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1	132
Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2–p12.1	132
The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter	130
Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1	129
Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis	129
Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors	126
Epstein–Barr virus infection in humans: from harmless to life endangering virus–lymphocyte interactions	125
Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes	124
Characterization of mammary tumors from Brg1 heterozygous mice	124
Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI	124
Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria	124
MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer	122
Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis	120
Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance	119
Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer	118
Lessons learned from BRCA1 and BRCA2	118
Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10	117
Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation	117
New insights into cell cycle control from the Drosophila endocycle	117

CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin–TGFβ signaling	115
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient	115
WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer	115
In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A	114
KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner	113
The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment	113
Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance	113
Direct cancer tissue proteomics: a method to identify candidate cancer biomarkers from formalin-fixed paraffin-embedded archival tissues	112
Drosophila AP-1: lessons from an invertebrate	111
ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival	110
Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis	110
An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment	110
Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade	109
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition	108
Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer	108
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell – cell contacts	107
p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage	106
Connexins in cancer: bridging the gap to the clinic	105
Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer	105
Microenvironmental oxygen pressure orchestrates an anti- and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes	105
IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma	104
Regulation of angiogenesis: apoptotic cues from the ECM	103
Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24	103
Extracellular vesicles swarm the cancer microenvironment: from tumor–stroma communication to drug intervention	103
p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-κB activity and Fas expression	102
CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation	101
Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis	101
Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway	100
Radiation carcinogenesis: lessons from Chernobyl	99
Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling	98
Males absent on the first (MOF): from flies to humans	98
Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-κB and Myc/Max	98
Breast cancer metastases are molecularly distinct from their primary tumors	97
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells	97
A Sox2–Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells	95
Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target	95
Exosome-mediated transfer of lncRUNX2-AS1 from multiple myeloma cells to MSCs contributes to osteogenesis	95
The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells	95
Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein – Barr virus	94
Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer	94
Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis	93
circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer	93
Proteomic analysis reveals successive aberrations in protein expression from healthy mucosa to invasive head and neck cancer	92
From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents	92
Identification of radiation-specific responses from gene expression profile	92
Drug methylation in cancer therapy: lessons from the TPMT polymorphism	92
p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells	91
Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions	91
Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor	91
BCR/ABL: from molecular mechanisms of leukemia induction to treatment of chronic myelogenous leukemia	91
Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon	91
The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs	90
Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex	90
Circulating cell-free DNA in breast cancer: size profiling, levels, and methylation patterns lead to prognostic and predictive classifiers	90
Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae	89
Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53	89
Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma	89
The role of translation in neoplastic transformation from a pathologist's point of view	89
Jak2 inhibition deactivates Lyn kinase through the SET–PP2A–SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients	88
NF-κB-dependent MnSOD expression protects adenocarcinoma cells from TNF-α-induced apoptosis	88
Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors	88
The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1	87
Rho GTPases in cancer: friend or foe?	87
SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond	86
miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer	86
Mitochondrial fission causes cisplatin resistance under hypoxic conditions via ROS in ovarian cancer cells	85
Induction of heat shock proteins by heregulin β1 leads to protection from apoptosis and anchorage-independent growth	85
Neurotransmitters: emerging targets in cancer	85
Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients	84
Long-term tumor-free survival from treatment with the GFP–TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells	84
LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P	83
piRNA-823 delivered by multiple myeloma-derived extracellular vesicles promoted tumorigenesis through re-educating endothelial cells in the tumor environment	83
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition	83
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors	82
Apoptotic cues from the extracellular matrix: regulators of angiogenesis	82
BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo	82
Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer	82
G-proteins in growth and apoptosis: lessons from the heart	82
Tumour exosomes from cells harbouring PTPRZ1–MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma	81
YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage	80

RGD peptides released from βig-h3, a TGF-β-induced cell-adhesive molecule, mediate apoptosis	80
Induction of cells with cancer stem cell properties from nontumorigenic human mammary epithelial cells by defined reprogramming factors	80
Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1	80
Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions	79
Wild-type blocking polymerase chain reaction for detection of single nucleotide minority mutations from clinical specimens	79
Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression	79
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo	78
Heat-shock proteins: chaperoning DNA repair	77
Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors	77
mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53	76
The unexpected role of lymphotoxin β receptor signaling in carcinogenesis: from lymphoid tissue formation to liver and prostate cancer development	76
STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells	76
Epstein-Barr virus EBNA3C can disrupt multiple cell cycle checkpoints and induce nuclear division divorced from cytokinesis	76
miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT	75
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4	74
Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control	74
Hsa_circ_0001361 promotes bladder cancer invasion and metastasis through miR-491-5p/MMP9 axis	74
A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene	74
Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-κB but is related to downregulation of initiator caspases and DR4	73
Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties through adipsin	73
Characterization of p53 oligomerization domain mutations isolated from Li–Fraumeni and Li–Fraumeni like family members	73
Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles	72
Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis	72
MicroRNA-mediated breast cancer metastasis: from primary site to distant organs	72
The UVB-induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes	72
A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer	71
NUDT21 regulates circRNA cyclization and ceRNA crosstalk in hepatocellular carcinoma	71
Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis	71
Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca2+/PI3K/AKT pathway	71
ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts	71
Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128	71
MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells	71
Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL	71
Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis	70
miR-34c may protect lung cancer cells from paclitaxel-induced apoptosis	70
Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin	69
Ovarian cancer ascites protects from TRAIL-induced cell death through αvβ5 integrin-mediated focal adhesion kinase and Akt activation	69
The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family	69
Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-β pathway	69
Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation	68
Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts	68
EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin	68
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration	68
Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis	68
Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer	67
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma	67
A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes	67
Eph receptor signalling: from catalytic to non-catalytic functions	67
ATF-2 controls transcription of Maspin and GADD45α genes independently from p53 to suppress mammary tumors	67
Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer	66
The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance	66
Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway	66
PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor	66
O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit	66
Gz signaling: emerging divergence from Gi signaling	66
Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis	65
Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma	65
Long non-coding RNA NONHSAT101069 promotes epirubicin resistance, migration, and invasion of breast cancer cells through NONHSAT101069/miR-129-5p/Twist1 axis	64
A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome	64
Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer	63
Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin	63
ASPM promotes prostate cancer stemness and progression by augmenting Wnt−Dvl-3−β-catenin signaling	62
EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis	62
Tissue necrosis and its role in cancer progression	62
Hsa_circ_101555 functions as a competing endogenous RNA of miR-597-5p to promote colorectal cancer progression	62
Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers	62
HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells	62
Type I and type II reactions in TRAIL-induced apoptosis – results from dose–response studies	61
Linc00173 promotes chemoresistance and progression of small cell lung cancer by sponging miR-218 to regulate Etk expression	61
Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities	61
Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis	61
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma	61
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis	61
Apolipoprotein C-1 maintains cell survival by preventing from apoptosis in pancreatic cancer cells	60
NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer	60
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2	60
An HER3-targeting antibody–drug conjugate incorporating a DNA topoisomerase I inhibitor U3-1402 conquers EGFR tyrosine kinase inhibitor-resistant NSCLC	59
The E7 protein from human papillomavirus type 16 enhances keratinocyte migration in an Akt-dependent manner	59
A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1	59
Base excision repair regulates PD-L1 expression in cancer cells	59
Unbalanced YAP–SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma	59
EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene	59
Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cells	58
Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein	58
Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets	58
MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer	58
The miR-186-3p/EREG axis orchestrates tamoxifen resistance and aerobic glycolysis in breast cancer cells	58
Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells	58
Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence	58
EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids	57
The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress	57
Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion	57
Secondary peripheral chondrosarcoma evolving from osteochondroma as a result of outgrowth of cells with functional EXT	57
Notch3: from subtle structural differences to functional diversity	57
IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma	57
Establishment of a monkey kidney epithelial cell line with the BARF1 open reading frame from Epstein-Barr Virus	57
Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis	57
KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC	56
Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases	56
Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Cι-mediated attenuation of p38 MAP kinase signaling	56
B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis	56
BCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlations	56
Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer	55
Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase	55
The lncRNA BORG facilitates the survival and chemoresistance of triple-negative breast cancers	55
AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation	55
Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum	55
How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42	55
Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding	54
The molecular and cell biology of pediatric low-grade gliomas	54
Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis	54
Does the reservoir for self-renewal stem from the ends?	54
Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway	54
Bclaf1 promotes angiogenesis by regulating HIF-1α transcription in hepatocellular carcinoma	54
Circular RNA profile identifies circOSBPL10 as an oncogenic factor and prognostic marker in gastric cancer	54
Binding of human papillomavirus 16 E5 to the 16 kDa subunit c (proteolipid) of the vacuolar H+-ATPase can be dissociated from the E5-mediated epidermal growth factor receptor overactivation	53
Exosome-derived miR-339-5p mediates radiosensitivity by targeting Cdc25A in locally advanced esophageal squamous cell carcinoma	53
Targeting the FANCJ–BRCA1 interaction promotes a switch from recombination to polη-dependent bypass	53
MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway	53
Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells	53
Mesenchymal cells generated from patients with myelodysplastic syndromes are devoid of chromosomal clonal markers and support short- and long-term hematopoiesis in vitro	52
ERBB3 mutations in cancer: biological aspects, prevalence and therapeutics	52
Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma	52
Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma	52
Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance	52
Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site	52
Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis	52
Nodal-dependant Cripto signaling in ES cells: from stem cells to tumor biology	52
Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice	51
IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells	51
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling	51
The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis	51
Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma	51
Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo	51
LCE: an open web portal to explore gene expression and clinical associations in lung cancer	51
Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality	50
Targeting colon cancer with the novel STAT3 inhibitor bruceantinol	50
Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1	50
Complementing mutations in core binding factor leukemias: from mouse models to clinical applications	50
USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis	50
Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics	49
Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A	49
TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis	49
The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis	49
Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size	49

Dexamethasone-mediated protection from drug cytotoxicity: association with p21WAF1/CIP1 protein accumulation?	49
TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment	49
In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter	49
Oncogenic microRNA-411 promotes lung carcinogenesis by directly targeting suppressor genes SPRY4 and TXNIP	49
Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis	49
MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target	48
Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment	48
Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis	48
R-Ras is regulated by activators and effectors distinct from those that control Ras function	48
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma	48
Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines	48
Adipose stromal cell targeting suppresses prostate cancer epithelial-mesenchymal transition and chemoresistance	48
A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein	48
The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation	48
TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance	48
Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner	48
Hsp90ab1 stabilizes LRP5 to promote epithelial–mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression	48
A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating cells isolated from a Brca1-associated mouse model of breast cancer	48
Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells	48
Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death	48