Oncogene

Article	Citations
A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma	151
A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability	144
The functional roles of TCA cycle metabolites in cancer	138
Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations	131
Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines	125
Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity	118
Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo	110
HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence	105
HDAC inhibition potentiates anti-tumor activity of macrophages and enhances anti-PD-L1-mediated tumor suppression	98
Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches	96
CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1	96
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis	91
Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma	90
STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis	88
Counteracting CAR T cell dysfunction	87
Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer	83
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy	82
Hypoxic exosomal HIF-1α-stabilizing circZNF91 promotes chemoresistance of normoxic pancreatic cancer cells via enhancing glycolysis	81
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy	79
Loss and revival of androgen receptor signaling in advanced prostate cancer	78
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization	76
Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance	73
RETRACTED ARTICLE: MSC-induced lncRNA AGAP2-AS1 promotes stemness and trastuzumab resistance through regulating CPT1 expression and fatty acid oxidation in breast cancer	71
Oncogenic functions and therapeutic targeting of EphA2 in cancer	70
Plasma exosomes from endometrial cancer patients contain LGALS3BP to promote endometrial cancer progression	68

Partial EMT in head and neck cancer biology: a spectrum instead of a switch	68
ROS production by mitochondria: function or dysfunction?	68
Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment	66
N7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-catenin pathway in nasopharyngeal carcinoma	66
Is PD-L1 a consistent biomarker for anti-PD-1 therapy? The model of balstilimab in a virally-driven tumor	66
Role of p38 MAP kinase in cancer stem cells and metastasis	62
Turning up the heat on non-immunoreactive tumors: pyroptosis influences the tumor immune microenvironment in bladder cancer	62
The role of MET in chemotherapy resistance	62
Nerve fibers in the tumor microenvironment in neurotropic cancer—pancreatic cancer and cholangiocarcinoma	61
A highly annotated database of genes associated with platinum resistance in cancer	60
DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway	60
LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit	60
A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination	59
VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk	59
Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions	59
METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2	58
METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent manner	58
The role of natural killer cell in gastrointestinal cancer: killer or helper	57
Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients	56
MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling	56
CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation	56
The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2	54
Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand	54
COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells	53
CD8+ T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer	53
Supercharging BRD4 with NUT in carcinoma	53
CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer	53
Cancer biology and molecular genetics of A3 adenosine receptor	51
Tumor-associated macrophages promote PD-L1 expression in tumor cells by regulating PKM2 nuclear translocation in pancreatic ductal adenocarcinoma	51
Going beyond Polycomb: EZH2 functions in prostate cancer	51
Going circular: history, present, and future of circRNAs in cancer	50
Targeting STAT3 by a small molecule suppresses pancreatic cancer progression	50
Clocking cancer: the circadian clock as a target in cancer therapy	49
Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment	49
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies	49
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer	49
Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPβ-mediated PDGFB autocrine and paracrine signaling	48
C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism	48
Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer	48
Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness and metabolism in lung cancer metastasis	48
The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA–RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis	47
BRD4 inhibition sensitizes cervical cancer to radiotherapy by attenuating DNA repair	47
Tumor-derived exosomes deliver the tumor suppressor miR-3591-3p to induce M2 macrophage polarization and promote glioma progression	47
Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation	47
Antibody-based cancer therapy	47
The role of R-spondin proteins in cancer biology	47
Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis	46
STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts	45
PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer	45
Malignant peripheral nerve sheath tumor: models, biology, and translation	45

Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling	45
Aurora-A kinase oncogenic signaling mediates TGF-β-induced triple-negative breast cancer plasticity and chemoresistance	44
Tumor-derived exosomal long noncoding RNA LINC01133, regulated by Periostin, contributes to pancreatic ductal adenocarcinoma epithelial-mesenchymal transition through the Wnt/β-catenin pathway by sile	44
RBMX suppresses tumorigenicity and progression of bladder cancer by interacting with the hnRNP A1 protein to regulate PKM alternative splicing	44
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma	44
STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway	44
CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages through physical interactions with TGF-β receptors in colorectal cancer	43
Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways	43
YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer	43
PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer	43
MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cells	43
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential	43
Functional characterization of uveal melanoma oncogenes	43
Myeloid-derived suppressor cells promote lung cancer metastasis by CCL11 to activate ERK and AKT signaling and induce epithelial-mesenchymal transition in tumor cells	42
Small non-coding RNAs in human cancer: function, clinical utility, and characterization	42
Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer	42
Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma	42
Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression	42
Lymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a	41
A dysbiotic microbiome promotes head and neck squamous cell carcinoma	39
CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic Hedgehog-Medulloblastoma model	39
How artificial intelligence might disrupt diagnostics in hematology in the near future	39
EphA2–YES1–ANXA2 pathway promotes gastric cancer progression and metastasis	39
The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions	39
FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis	39
Glioblastoma heterogeneity at single cell resolution	39
CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway	38
POLE, POLD1, and NTHL1: the last but not the least hereditary cancer-predisposing genes	38
IGF1R acts as a cancer-promoting factor in the tumor microenvironment facilitating lung metastasis implantation and progression	38
The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity	38
Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges	38
Selective inhibition of stemness through EGFR/FOXA2/SOX9 axis reduces pancreatic cancer metastasis	38
Transcription factors in colorectal cancer: molecular mechanism and therapeutic implications	38
CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis	37
Polyploid giant cancer cells, stemness and epithelial-mesenchymal plasticity elicited by human cytomegalovirus	37
YTHDF2 is a potential target of AML1/ETO-HIF1α loop-mediated cell proliferation in t(8;21) AML	37
The HSF1/miR-135b-5p axis induces protective autophagy to promote oxaliplatin resistance through the MUL1/ULK1 pathway in colorectal cancer	36
NK and NKT cells have distinct properties and functions in cancer	36
The m6A reading protein YTHDF3 potentiates tumorigenicity of cancer stem-like cells in ocular melanoma through facilitating CTNNB1 translation	36
FOXO3a-driven miRNA signatures suppresses VEGF-A/NRP1 signaling and breast cancer metastasis	35
Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics	35
Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence	35
Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-κB signaling	35
Meta-analysis of mucosal microbiota reveals universal microbial signatures and dysbiosis in gastric carcinogenesis	35
SOX2 mediates metabolic reprogramming of prostate cancer cells	35
KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer	35
Comprehensive characterisation of intronic mis-splicing mutations in human cancers	35
Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer	35
CTGF regulates cell proliferation, migration, and glucose metabolism through activation of FAK signaling in triple-negative breast cancer	35
Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF-mutant melanoma	35
POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation	35
OGT regulated O-GlcNAcylation promotes papillary thyroid cancer malignancy via activating YAP	34
ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab	34
Altered gut microbiome composition by appendectomy contributes to colorectal cancer	34
LncRNA GAL promotes colorectal cancer liver metastasis through stabilizing GLUT1	34
NSD2 promotes tumor angiogenesis through methylating and activating STAT3 protein	34
Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma	34
Src: coordinating metabolism in cancer	34
Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases	34
DNA methylome profiling of circulating tumor cells in lung cancer at single base-pair resolution	34
Androgen receptor promotes renal cell carcinoma (RCC) vasculogenic mimicry (VM) via altering TWIST1 nonsense-mediated decay through lncRNA-TANAR	33
N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing	33
The proprotein convertase furin in cancer: more than an oncogene	33
Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis	33
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer	33
N6-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression	33
DNMT1-mediated epigenetic silencing of TRAF6 promotes prostate cancer tumorigenesis and metastasis by enhancing EZH2 stability	32
Plectin is a regulator of prostate cancer growth and metastasis	32
Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53	32
M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression	32
PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma	32
Recent advances in preclinical models for lung squamous cell carcinoma	32
O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis	31
p53 partial loss-of-function mutations sensitize to chemotherapy	31
BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors	31
Nerve growth factor receptor increases the tumor growth and metastatic potential of triple-negative breast cancer cells	31
Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway	31
Radiation-induced YAP activation confers glioma radioresistance via promoting FGF2 transcription and DNA damage repair	31
αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression	31
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L	30

ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma	30
YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis	30
O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation	30
LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target	30
SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis	30
NOP10 predicts lung cancer prognosis and its associated small nucleolar RNAs drive proliferation and migration	30
Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS	30
OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer	30
CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis	30
The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer	30
HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer	29
Glioblastoma-associated microglia-derived exosomal circKIF18A promotes angiogenesis by targeting FOXC2	29
STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway	29
Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma	29
PARP14 regulates cyclin D1 expression to promote cell-cycle progression	29
The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy	29
Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers	29
KIAA1429 is a potential prognostic marker in colorectal cancer by promoting the proliferation via downregulating WEE1 expression in an m6A-independent manner	29
Spontaneous and inherited TP53 genetic alterations	29
AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms	29
CEMIP, a novel adaptor protein of OGT, promotes colorectal cancer metastasis through glutamine metabolic reprogramming via reciprocal regulation of β-catenin	29
Cell-type deconvolution analysis identifies cancer-associated myofibroblast component as a poor prognostic factor in multiple cancer types	29
Positive feedback regulation of lncRNA PVT1 and HIF2α contributes to clear cell renal cell carcinoma tumorigenesis and metastasis	28
Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth	28
miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche	28
Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic	28
Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair	28
A detailed characterization of stepwise activation of the androgen receptor variant 7 in prostate cancer cells	28
RNA bisulfite sequencing reveals NSUN2-mediated suppression of epithelial differentiation in pancreatic cancer	28
Molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon reveals potential new therapeutic targets	28
Epiregulin confers EGFR-TKI resistance via EGFR/ErbB2 heterodimer in non-small cell lung cancer	28
The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target	28
Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC	28
Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis	28
The role of polyamines in gastric cancer	28
FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs	27
RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7	27
Applicability of liquid biopsies to represent the mutational profile of tumor tissue from different cancer entities	27
FOXM1 is required for small cell lung cancer tumorigenesis and associated with poor clinical prognosis	27
FBP1 regulates proliferation, metastasis, and chemoresistance by participating in C-MYC/STAT3 signaling axis in ovarian cancer	27
CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis	27
DCision-making in tumors governs T cell anti-tumor immunity	27
Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancer	27
Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma	27
MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression	27
PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma	26
FOXP1 drives osteosarcoma development by repressing P21 and RB transcription downstream of P53	26
FRMD6 has tumor suppressor functions in prostate cancer	26
G9a controls pluripotent-like identity and tumor-initiating function in human colorectal cancer	26
Monitoring the 5′UTR landscape reveals isoform switches to drive translational efficiencies in cancer	26
A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer	26
Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer	26
Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer	26
H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma	26
A micropeptide XBP1SBM encoded by lncRNA promotes angiogenesis and metastasis of TNBC via XBP1s pathway	26
β-Catenin-CCL2 feedback loop mediates crosstalk between cancer cells and macrophages that regulates breast cancer stem cells	26
PP2A-B55: substrates and regulators in the control of cellular functions	26
SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer	26
ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer	26
C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv	26
Classifying gastric cancer using FLORA reveals clinically relevant molecular subtypes and highlights LINC01614 as a biomarker for patient prognosis	25
IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination	25
Mechanisms driving chromosomal translocations: lost in time and space	25
Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth	25
SMARCA4 oncogenic potential via IRAK1 enhancer to activate Gankyrin and AKR1B10 in liver cancer	25
The molecular march of primary and recurrent nasopharyngeal carcinoma	25
Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis	25
RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2-dependent manner	25
The critical role of STAT3 in biogenesis of tumor-derived exosomes with potency of inducing cancer cachexia in vitro and in vivo	25
Mutant collagen COL11A1 enhances cancerous invasion	25
Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer	25
Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis	25
p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance	25
MALAT1 modulated FOXP3 ubiquitination then affected GINS1 transcription and drived NSCLC proliferation	25
Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer	25
HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer	24
miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma	24
The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors	24
MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3	24
CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing β-catenin	24
Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells	24
The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers	24
M6A methylation of DEGS2, a key ceramide-synthesizing enzyme, is involved in colorectal cancer progression through ceramide synthesis	24
Wnt-TCF7-SOX9 axis promotes cholangiocarcinoma proliferation and pemigatinib resistance in a FGF7-FGFR2 autocrine pathway	24
RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-κB and MAPK signaling pathways	24
IDH2 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in multiple myeloma	24
The NQO1/p53/SREBP1 axis promotes hepatocellular carcinoma progression and metastasis by regulating Snail stability	24
P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis	24
NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancer	24
LncRNA PINK1-AS promotes Gαi1-driven gastric cancer tumorigenesis by sponging microRNA-200a	24
PARK7 maintains the stemness of glioblastoma stem cells by stabilizing epidermal growth factor receptor variant III	24
Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity	24
Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach	24
Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance	24
CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1	24