Development

Article	Citations
Retinal organoids: a window into human retinal development	90
Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features	82
Bioelectric signaling as a unique regulator of development and regeneration	77
A single-cell atlas of mouse lung development	77
Stem cell quiescence: the challenging path to activation	74
Understanding axial progenitor biology in vivo and in vitro	73
Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart	68
Characterization of primary models of human trophoblast	61
Normal Table of Xenopus development: a new graphical resource	60
Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapia	58
Axial elongation of caudalized human organoids mimics aspects of neural tube development	52
Mammalian primordial germ cell specification	52
Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment	52
TEAD family transcription factors in development and disease	52
TGFβ family signaling and development	51
Cyclical endometrial repair and regeneration	50
Arabidopsis root responses to salinity depend on pectin modification and cell wall sensing	49
Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment	48
Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species	46
Segmentation and patterning of the vertebrate hindbrain	46
WNT signaling in pre-granulosa cells is required for ovarian folliculogenesis and female fertility	45
Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridization	45
The many bits of positional information	44
Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks	44
CNS macrophages differentially rely on an intronicCsf1renhancer for their development	43

MOrgAna: accessible quantitative analysis of organoids with machine learning	43
Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification	42
Developmental single-cell transcriptomics in the Lytechinus variegatus sea urchin embryo	42
The origins and roles of osteoclasts in bone development, homeostasis and repair	41
Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development	40
What determines organ size during development and regeneration?	38
Deep learning for bioimage analysis in developmental biology	38
Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation	38
Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition	38
Human assembloids	37
HY5 and phytochrome activity modulate shoot-to-root coordination during thermomorphogenesis in Arabidopsis	37
lncRNAs in development and differentiation: from sequence motifs to functional characterization	36
Tissue clearing and 3D imaging in developmental biology	35
Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse	35
The multiple facets of Cajal-Retzius neurons	35
The road to generating transplantable organs: from blastocyst complementation to interspecies chimeras	34
Sculpting with stem cells: how models of embryo development take shape	34
Human embryo implantation	34
Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation	34
Enhancer-gene specificity in development and disease	32
Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition	32
Stem cells in pulmonary alveolar regeneration	32
Nuclear pore complexes in development and tissue homeostasis	32
Inferring cell junction tension and pressure from cell geometry	31
The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency	31
Hedgehog signaling and the primary cilium: implications for spatial and temporal constraints on signaling	31
Hox genes in development and beyond	31
A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome	30
The origin and mechanisms of smooth muscle cell development in vertebrates	30
ERECTA family signaling constrains CLAVATA3 and WUSCHEL to the center of the shoot apical meristem	30
Microglia in brain development and regeneration	30
Development of the mammalian main olfactory bulb	30
The development and stem cells of the esophagus	30
Single-nuclei transcriptome analysis of the shoot apex vascular system differentiation in Populus	29
Retinal ganglion cell interactions shape the developing mammalian visual system	29
Mechanical and signaling mechanisms that guide pre-implantation embryo movement	29
CFAP61 is required for sperm flagellum formation and male fertility in human and mouse	29
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds	29
The ECM as a driver of heart development and repair	29
The complex three-dimensional organization of epithelial tissues	29
Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice	28
Self-organized cell migration across scales – from single cell movement to tissue formation	28
Developmental mechanisms of sex differences: from cells to organisms	28
Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature	28
Distinct contributions of ECM proteins to basement membrane mechanical properties in Drosophila	28
Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force	28
Gene expression variation in Arabidopsis embryos at single-nucleus resolution	26
SCARECROW is deployed in distinct contexts during rice and maize leaf development	26
Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells	26
Cyclical fate restriction: a new view of neural crest cell fate specification	25

Ceramides mediate positional signals in Arabidopsis thaliana protoderm differentiation	24
Integrated molecular analysis identifies a conserved pericyte gene signature in zebrafish	24
Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain	24
Development and maintenance of tendons and ligaments	24
Biology of resident tissue macrophages	24
Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs	24
Asynchrony of ovule primordia initiation in Arabidopsis	24
A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish	23
Cell cycle control during early embryogenesis	23
Single-cell morphometrics reveals ancestral principles of notochord development	23
Model systems for regeneration:Arabidopsis	23
The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development	23
Diversity and robustness of bone morphogenetic protein pattern formation	23
Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration	23
Wnt/beta-catenin signalling is dispensable for adult neural stem cell homeostasis and activation	23
Knock-in tagging in zebrafish facilitated by insertion into non-coding regions	23
Gynoecium and fruit development in Arabidopsis	23
Immune cells in cardiac repair and regeneration	22
FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway	22
Quantitative developmental biology in vitro using micropatterning	22
Polyploid cardiomyocytes: implications for heart regeneration	22
Mosaic CRISPR-stop enables rapid phenotyping of nonsense mutations in essential genes	22
The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration	22
Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster	22
Regulatory mechanisms governing epidermal stem cell function during development and homeostasis	21
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum	21
longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth	21
Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse	21
Symbiosis: the other cells in development	21
KATNB1 is a master regulator of multiple katanin enzymes in male meiosis and haploid germ cell development	21
Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts	21
The biomechanical basis of biased epithelial tube elongation in lung and kidney development	21
Stable iPSC-derived NKX2-1+ lung bud tip progenitor organoids give rise to airway and alveolar cell types	21
Age reprogramming: cell rejuvenation by partial reprogramming	21
High temperature perception in leaves promotes vascular regeneration and graft formation in distant tissues	21
What machine learning can do for developmental biology	20
Msl3 promotes germline stem cell differentiation in female Drosophila	20
An L-type lectin receptor-like kinase promotes starch accumulation during rice pollen maturation	20
The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development	20
The Drosophila ribosome protein S5 paralog RpS5b promotes germ cell and follicle cell differentiation during oogenesis	20
Cell type-specific dynamics underlie cellular growth variability in plants	20
Focal adhesion-mediated cell anchoring and migration: fromin vitrotoin vivo	20
Visualizing polymeric components that define distinct root barriers across plant lineages	20
Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells	20
Germ cell determination and the developmental origin of germ cell tumors	20
Enhancer RNAs step forward: new insights into enhancer function	20
Cell state transitions: definitions and challenges	20
APETALA2 functions as a temporal factor together with BLADE-ON-PETIOLE2 and MADS29 to control flower and grain development in barley	20
The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing	20
The origin and role of the renal stroma	20
Proper timing of a quiescence period in precursor prospermatogonia is required for stem cell pool establishment in the male germline	19
Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives	19
CCDC38 is required for sperm flagellum biogenesis and male fertility in mice	19
Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents	19
Robustness and timing of cellular differentiation through population-based symmetry breaking	19
Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity	19
Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling	19
Rectified random cell motility as a mechanism for embryo elongation	19
Dynamics of hunchback translation in real-time and at single-mRNA resolution in the Drosophila embryo	19
In vitro models of the human heart	19
An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters	19
Aster repulsion drives short-ranged ordering in the Drosophila syncytial blastoderm	19
Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis	19
A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina	19
Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids	19
Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice	19
Calcium and activity-dependent signaling in the developing cerebral cortex	19
Metaphloem development in the Arabidopsis root tip	18
C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella	18
Deep learning is widely applicable to phenotyping embryonic development and disease	18
FGF signalling plays similar roles in development and regeneration of the skeleton in the brittle star Amphiura filiformis	18
DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development	18
An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells	18
Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants	18
The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis	18
FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice	18
Sequestration to lipid droplets promotes histone availability by preventing turnover of excess histones	18
Avian auditory hair cell regeneration is accompanied by JAK/STAT-dependent expression of immune-related genes in supporting cells	18
Building neuromuscular junctions in vitro	18
Notch signaling in development and homeostasis	18

Shedding light on developmental ERK signaling with genetically encoded biosensors	18
Premeiotic endoreplication is essential for obligate parthenogenesis in geckos	18
Single-molecule tracking technologies for quantifying the dynamics of gene regulation in cells, tissue and embryos	18
Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing	17
Exocrine gland structure-function relationships	17
PEG10 viral aspartic protease domain is essential for the maintenance of fetal capillary structure in the mouse placenta	17
INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes	17
Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations	17
Towards understanding the origin of animal development	17
Molecular and cellular architecture of the larval sensory organ in the cnidarian Nematostella vectensis	17
Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation	17
Expansion and innovation in auxin signaling: where do we grow from here?	17
Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis	17
Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration	17
Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity	17
A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development	16
Reprogramming cellular identity in vivo	16
Clathrin-mediated endocytosis is essential for the selective degradation of maternal membrane proteins and preimplantation development	16
Ciona embryonic tail bending is driven by asymmetrical notochord contractility and coordinated by epithelial proliferation	16
Ethylene signaling increases reactive oxygen species accumulation to drive root hair initiation in Arabidopsis	16
Fatty acid-binding proteins and fatty acid synthase influence glial reactivity and promote the formation of Müller glia-derived progenitor cells in the chick retina	16
Defining epithelial-mesenchymal transitions in animal development	16
A dynamic and mosaic basement membrane controls cell intercalation in Drosophila ovaries	16
Dynamic properties of mitochondria during human corticogenesis	16
Lipid metabolism in focus: how the build-up and breakdown of lipids affects stem cells	16
It takes all kinds: heterogeneity among satellite cells and fibro-adipogenic progenitors during skeletal muscle regeneration	16
Generation of a homozygous mutant drug transporter (ABCB1) knockout line in the sea urchinLytechinus pictus	16
SyNPL: Synthetic Notch pluripotent cell lines to monitor and manipulate cell interactions in vitro and in vivo	16
Gene expression profiling of epidermal cell types in C. elegans using Targeted DamID	16
Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development	16
Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice	16
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development	16
Tcf12 and NeuroD1 cooperatively drive neuronal migration during cortical development	15
The Caenorhabditis elegans anchor cell transcriptome: ribosome biogenesis drives cell invasion through basement membrane	15
The lysine deacetylase activity of histone deacetylases 1 and 2 is required to safeguard zygotic genome activation in mice and cattle	15
When form meets function: the cells and signals that shape the lymphatic vasculature during development	15
TMEM8C-mediated fusion is regionalized and regulated by NOTCH signalling during foetal myogenesis	15
A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling	15
Notch signaling enhances bone regeneration in the zebrafish mandible	15
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation	15
Increased lateral tension is sufficient for epithelial folding in Drosophila	15
The Arabidopsis stomatal polarity protein BASL mediates distinct processes before and after cell division to coordinate cell size and fate asymmetries	15
Sperm-borne miR-202 targets SEPT7 and regulates first cleavage of bovine embryos via cytoskeletal remodeling	15
Current approaches to fate mapping and lineage tracing using image data	15
Toll signalling promotes blastema cell proliferation during cricket leg regeneration via insect macrophages	15
E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling	15
Time to go: neural crest cell epithelial-to-mesenchymal transition	15
Technical challenges of studying early human development	15
Hypomorphic and hypermorphic mouse models of Fsip2 indicate its dosage-dependent roles in sperm tail and acrosome formation	15
Single-cell RNA sequencing reveals PDGFRα+ stromal cell subpopulations that promote proacinar cell differentiation in embryonic salivary gland organoids	15
Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies	15
Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis	15
Live imaging of the Drosophila ovarian niche shows spectrosome and centrosome dynamics during asymmetric germline stem cell division	15
The initiation knot is a signaling center required for molar tooth development	15
Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum	15
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling	15
KLF17 promotes human naïve pluripotency but is not required for its establishment	15
Autophagy promotes organelle clearance and organized cell separation of living root cap cells in Arabidopsis thaliana	14
Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds	14
Reactive oligodendrocyte progenitor cells (re-)myelinate the regenerating zebrafish spinal cord	14
Lmo7 recruits myosin II heavy chain to regulate actomyosin contractility and apical domain size inXenopusectoderm	14
Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior	14
A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals	14
Neuronal differentiation strategies: insights from single-cell sequencing and machine learning	14
Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos	14
PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation	14
Defective mesothelium and limited physical space are drivers of dysregulated lung development in a genetic model of congenital diaphragmatic hernia	14
Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions	14
Planar cell polarity: moving from single cells to tissue-scale biology	14
The zebrafish issue: 25 years on	14
Embryonic development in the acoelHofstenia miamia	14
LncRNA HBL1 is required for genome-wide PRC2 occupancy and function in cardiogenesis from human pluripotent stem cells	14
Srsf3 mediates alternative RNA splicing downstream of PDGFRα signaling in the facial mesenchyme	14
A new CUT&RUN low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/β-catenin tissue-specific genomic targets	14
Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation	14
Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development	14
Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging	14
Natural killer cells act as an extrinsic barrier for in vivo reprogramming	14
Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development	14
FGF signaling acts on different levels of mesoderm development within Spiralia	13
Sobp modulates the transcriptional activation of Six1 target genes and is required during craniofacial development	13
Testicular germ cell tumors arise in the absence of sex-specific differentiation	13
Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors inCaenorhabditis elegans	13
Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis	13
A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression	13
A molecular and cellular analysis of human embryonic optic fissure closure related to the eye malformation coloboma	13
Microbial influences on gut development and gut-brain communication	13
ABI transcription factors and PROTEIN L-ISOASPARTYL METHYLTRANSFERASE module mediate seed desiccation tolerance and longevity in Oryza sativa	13
Regenerative neurogenesis: the integration of developmental, physiological and immune signals	13
Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle	13
Immune landscape of human placental villi using single-cell analysis	13
Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival	13
Identification of disease-relevant modulators of the SHH pathway in the developing brain	13
Selective Cdk9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish	13
WASp controls oriented migration of endothelial cells to achieve functional vascular patterning	13