Development

Article	Citations
The extracellular matrix in development	203
Mechanisms of human embryo development: from cell fate to tissue shape and back	110
The lateral plate mesoderm	88
Principles and mechanisms of asymmetric cell division	82
Retinal organoids: a window into human retinal development	80
Development of the cochlea	71
A single-cell atlas of mouse lung development	66
Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features	66
Bioelectric signaling as a unique regulator of development and regeneration	64
The molecular and cellular features of 2-cell-like cells: a reference guide	62
Understanding axial progenitor biology in vivo and in vitro	58
Branching morphogenesis	58
Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart	55
Neuronal and glial regulation of CNS angiogenesis and barriergenesis	55
Stem cell quiescence: the challenging path to activation	54
Establishing the pattern of the vertebrate limb	51
The regulation of Yorkie, YAP and TAZ: new insights into the Hippo pathway	51
Characterization of primary models of human trophoblast	49
Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapia	47
From pluripotency to totipotency: an experimentalist's guide to cellular potency	46
Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment	46
Mechanisms of heart valve development and disease	45
Axial elongation of caudalized human organoids mimics aspects of neural tube development	44
Orchestrating morphogenesis: building the body plan by cell shape changes and movements	43
Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration	43

Development of a straight vertebrate body axis	43
The heart of the neural crest: cardiac neural crest cells in development and regeneration	41
Segmentation and patterning of the vertebrate hindbrain	41
Transcriptional adaptation: a mechanism underlying genetic robustness	41
TGFβ family signaling and development	41
Normal Table of Xenopus development: a new graphical resource	40
Mammalian primordial germ cell specification	39
Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment	39
WNT signaling in pre-granulosa cells is required for ovarian folliculogenesis and female fertility	38
Development and plasticity of the corpus callosum	38
Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation	37
Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases	37
GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells	37
TEAD family transcription factors in development and disease	36
Neural crest lineage analysis: from past to future trajectory	36
A single cell RNA sequencing resource for early sea urchin development	36
Cyclical endometrial repair and regeneration	36
Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification	35
Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks	35
Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridization	35
The many bits of positional information	35
Mechanical feedback-loop regulation of morphogenesis in plants	34
CNS macrophages differentially rely on an intronicCsf1renhancer for their development	33
Hallmarks of intestinal stem cells	33
What determines organ size during development and regeneration?	33
Arabidopsis root responses to salinity depend on pectin modification and cell wall sensing	33
Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species	33
Stochasticity and determinism in cell fate decisions	32
The multiple facets of Cajal-Retzius neurons	32
Insulin/IGF signaling and TORC1 promote vitellogenesis via inducing juvenile hormone biosynthesis in the American cockroach	32
The pulse of morphogenesis: actomyosin dynamics and regulation in epithelia	32
Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition	32
Developmental single-cell transcriptomics in the Lytechinus variegatus sea urchin embryo	31
Phyllotaxis as geometric canalization during plant development	31
MOrgAna: accessible quantitative analysis of organoids with machine learning	31
lncRNAs in development and differentiation: from sequence motifs to functional characterization	31
Circular RNAs in cell differentiation and development	30
Common principles of early mammalian embryo self-organisation	30
Understanding angiodiversity: insights from single cell biology	30
Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development	29
Hedgehog signaling and the primary cilium: implications for spatial and temporal constraints on signaling	29
Deep learning for bioimage analysis in developmental biology	29
Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse	28
Tissue clearing and 3D imaging in developmental biology	28
Sculpting with stem cells: how models of embryo development take shape	28
Gene-environment interactions: aligning birth defects research with complex etiology	28
HY5 and phytochrome activity modulate shoot-to-root coordination during thermomorphogenesis in Arabidopsis	27
Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation	27
Stem cells in pulmonary alveolar regeneration	27
Nuclear pore complexes in development and tissue homeostasis	27

The origins and roles of osteoclasts in bone development, homeostasis and repair	26
Model systems for regeneration: Drosophila	26
A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome	26
The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency	26
Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition	25
Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse	25
The complex three-dimensional organization of epithelial tissues	25
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds	24
FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research	24
Mechanical and signaling mechanisms that guide pre-implantation embryo movement	24
The road to generating transplantable organs: from blastocyst complementation to interspecies chimeras	24
The HK5 and HK6 cytokinin receptors mediate diverse developmental pathways in rice	24
Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature	24
Single-nuclei transcriptome analysis of the shoot apex vascular system differentiation in Populus	23
Transposable elements, circular RNAs and mitochondrial transcription in age-related genomic regulation	23
Development of the mammalian main olfactory bulb	23
Evidence of two types of balance between stem cell mitosis and enterocyte nucleus growth in the Drosophila midgut	23
Human assembloids	23
Inferring cell junction tension and pressure from cell geometry	23
Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force	23
Cell death in animal development	23
Ceramides mediate positional signals in Arabidopsis thaliana protoderm differentiation	22
The ECM as a driver of heart development and repair	22
New trends in cellular therapy	22
Asynchrony of ovule primordia initiation in Arabidopsis	22
Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain	22
Self-organized cell migration across scales – from single cell movement to tissue formation	22
Retinal ganglion cell interactions shape the developing mammalian visual system	22
Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration	22
The origin and mechanisms of smooth muscle cell development in vertebrates	22
Gene expression variation in Arabidopsis embryos at single-nucleus resolution	22
CFAP61 is required for sperm flagellum formation and male fertility in human and mouse	22
Wnt/beta-catenin signalling is dispensable for adult neural stem cell homeostasis and activation	21
Cyclical fate restriction: a new view of neural crest cell fate specification	21
Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus	21
Developmental mechanisms of sex differences: from cells to organisms	21
Single-cell morphometrics reveals ancestral principles of notochord development	21
From head to tail: regionalization of the neural crest	21
Evolution and development of complex eyes: a celebration of diversity	21
Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells	21
ERECTA family signaling constrains CLAVATA3 and WUSCHEL to the center of the shoot apical meristem	20
Quantitative developmental biology in vitro using micropatterning	20
SCARECROW is deployed in distinct contexts during rice and maize leaf development	20
MMP14 is required for delamination of chick neural crest cells independently of its catalytic activity	20
The development and stem cells of the esophagus	20
Mosaic CRISPR-stop enables rapid phenotyping of nonsense mutations in essential genes	20
Model systems for regeneration:Arabidopsis	20
Integrated molecular analysis identifies a conserved pericyte gene signature in zebrafish	20
Fluid flow as a driver of embryonic morphogenesis	19
Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes	19
Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs	19
Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice	19
APETALA2 functions as a temporal factor together with BLADE-ON-PETIOLE2 and MADS29 to control flower and grain development in barley	19
The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing	19
Distinct contributions of ECM proteins to basement membrane mechanical properties in Drosophila	19
Microglia in brain development and regeneration	19
Polyploid cardiomyocytes: implications for heart regeneration	19
Development and maintenance of tendons and ligaments	19
Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives	18
Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts	18
The biomechanical basis of biased epithelial tube elongation in lung and kidney development	18
Enhancer-gene specificity in development and disease	18
The Drosophila ribosome protein S5 paralog RpS5b promotes germ cell and follicle cell differentiation during oogenesis	18
Gynoecium and fruit development in Arabidopsis	18
High temperature perception in leaves promotes vascular regeneration and graft formation in distant tissues	18
CCDC38 is required for sperm flagellum biogenesis and male fertility in mice	17
Knock-in tagging in zebrafish facilitated by insertion into non-coding regions	17
Diversity and robustness of bone morphogenetic protein pattern formation	17
Building neuromuscular junctions in vitro	17
Cell state transitions: definitions and challenges	17
The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development	17
Germ cell determination and the developmental origin of germ cell tumors	17
Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster	17
Metaphloem development in the Arabidopsis root tip	17
Towards understanding the origin of animal development	17
Shedding light on developmental ERK signaling with genetically encoded biosensors	17
The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration	17
Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells	17
Null hypotheses for developmental evolution	17
Regulatory mechanisms governing epidermal stem cell function during development and homeostasis	17

Cell cycle control during early embryogenesis	17
Msl3 promotes germline stem cell differentiation in female Drosophila	17
What machine learning can do for developmental biology	16
Deep learning is widely applicable to phenotyping embryonic development and disease	16
An L-type lectin receptor-like kinase promotes starch accumulation during rice pollen maturation	16
Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse	16
Robustness and timing of cellular differentiation through population-based symmetry breaking	16
Aster repulsion drives short-ranged ordering in the Drosophila syncytial blastoderm	16
Stable iPSC-derived NKX2-1+ lung bud tip progenitor organoids give rise to airway and alveolar cell types	16
Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations	16
longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth	16
FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway	16
Biology of resident tissue macrophages	16
The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development	16
FGF signalling plays similar roles in development and regeneration of the skeleton in the brittle star Amphiura filiformis	16
Immune cells in cardiac repair and regeneration	16
Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity	16
Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice	15
Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing	15
In vitro models of the human heart	15
Expansion and innovation in auxin signaling: where do we grow from here?	15
The initiation knot is a signaling center required for molar tooth development	15
Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids	15
Cell type-specific dynamics underlie cellular growth variability in plants	15
A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina	15
Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation	15
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation	15
Enhancer RNAs step forward: new insights into enhancer function	15
Understanding generation and regeneration of pancreatic β cells from a single-cell perspective	15
Human embryo implantation	15
The origin and role of the renal stroma	14
Generation of a homozygous mutant drug transporter (ABCB1) knockout line in the sea urchinLytechinus pictus	14
The zebrafish issue: 25 years on	14
Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo	14
Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling	14
Rectified random cell motility as a mechanism for embryo elongation	14
Premeiotic endoreplication is essential for obligate parthenogenesis in geckos	14
Ciona embryonic tail bending is driven by asymmetrical notochord contractility and coordinated by epithelial proliferation	14
Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity	14
An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells	14
Fgf-driven Tbx protein activities directly inducemyf5andmyodto initiate zebrafish myogenesis	14
C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella	14
Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration	14
Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelid Capitella teleta	14
DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development	14
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling	14
Avian auditory hair cell regeneration is accompanied by JAK/STAT-dependent expression of immune-related genes in supporting cells	14
The Arabidopsis stomatal polarity protein BASL mediates distinct processes before and after cell division to coordinate cell size and fate asymmetries	14
The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis	14
Reprogramming cellular identity in vivo	14
KATNB1 is a master regulator of multiple katanin enzymes in male meiosis and haploid germ cell development	14
Toll signalling promotes blastema cell proliferation during cricket leg regeneration via insect macrophages	14
Sequestration to lipid droplets promotes histone availability by preventing turnover of excess histones	14
When form meets function: the cells and signals that shape the lymphatic vasculature during development	13
Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis	13
Current approaches to fate mapping and lineage tracing using image data	13
Ethylene signaling increases reactive oxygen species accumulation to drive root hair initiation in Arabidopsis	13
Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development	13
let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner ear	13
Exocrine gland structure-function relationships	13
Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis	13
Age reprogramming: cell rejuvenation by partial reprogramming	13
E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling	13
KLF17 promotes human naïve pluripotency but is not required for its establishment	13
Reactive oligodendrocyte progenitor cells (re-)myelinate the regenerating zebrafish spinal cord	13
Sperm-borne miR-202 targets SEPT7 and regulates first cleavage of bovine embryos via cytoskeletal remodeling	13
Responsible use of organoids in precision medicine: the need for active participant involvement	13
Understanding the role of lipids and lipoproteins in development	13
Dynamic properties of mitochondria during human corticogenesis	13
PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation	13
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development	13
Lmo7 recruits myosin II heavy chain to regulate actomyosin contractility and apical domain size in Xenopus ectoderm	13
Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior	13
Defining epithelial-mesenchymal transitions in animal development	13
Endogenous CRISPR/Cas9 arrays for scalable whole-organism lineage tracing	12
Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression	12
Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle	12
Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice	12
A molecular and cellular analysis of human embryonic optic fissure closure related to the eye malformation coloboma	12
Testicular germ cell tumors arise in the absence of sex-specific differentiation	12
It takes all kinds: heterogeneity among satellite cells and fibro-adipogenic progenitors during skeletal muscle regeneration	12
Neuronal differentiation strategies: insights from single-cell sequencing and machine learning	12
Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development	12
Coordinated assembly and release of adhesions builds apical junctional belts during de novo polarisation of an epithelial tube	12
A new CUT&RUN low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/β-catenin tissue-specific genomic targets	12
Development of vascular regulation in the zebrafish embryo	12
Microbial influences on gut development and gut-brain communication	12
Planar cell polarity: moving from single cells to tissue-scale biology	12
Gene expression profiling of epidermal cell types in C. elegans using Targeted DamID	12
Visualizing polymeric components that define distinct root barriers across plant lineages	12
Lipid metabolism in focus: how the build-up and breakdown of lipids affects stem cells	12
Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents	12
Hypomorphic and hypermorphic mouse models of Fsip2 indicate its dosage-dependent roles in sperm tail and acrosome formation	12
Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival	12
A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development	12