OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Molecular Medicine-Jmm is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Mitochondrial transplantation as a possible therapeutic option for sarcopenia	81
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy	75
Histone modification in podocyte injury of diabetic nephropathy	69
PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma	57
The PER3rs772027021 SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria	54
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway	50
Nets, pulmonary arterial hypertension, and thrombo-inflammation	42
Flotillin- 1 ameliorates experimental diabetic retinopathy by inhibiting ferroptosis in blood-retinal barrier	39
IGFBP2 function as a novel biomarker for active lupus nephritis	39
Neurovascular abnormalities in retinopathy of prematurity and emerging therapies	38
Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections	37
Synergistic effect of the sphingosine kinase inhibitor safingol in combination with 2'-nitroflavone in breast cancer	36
Rewriting the vascular script: epigenetic modifiers as scribes of metabolic reprogramming in pulmonary hypertension	35
Relationship between CXCR4 and GNG4 in the Brain and Chronic Stress-Induced Atherosclerosis	35
A comprehensive review of m6 A methylation in coronary heart disease	34
PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma	34
Inhibition of p38 MAPK decreases hyperglycemia-induced nephrin endocytosis and attenuates albuminuria	31
Circular RNAs: regulators of vascular smooth muscle cells in cardiovascular diseases	30
Fibrin as the mediator of tumor cell interaction with platelets	30
Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis	29
Genotypic analysis of a large cohort of patients with suspected atypical hemolytic uremic syndrome	29
CREB-H is a stress-regulator of hepcidin gene expression during early postnatal development	29
Acid-sensing ion channel 1a exacerbates renal ischemia–reperfusion injury through the NF-κB/NLRP3 inflammasome pathway	27
Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform	27
CircRNA CDR1AS promotes cardiac ischemia–reperfusion injury in mice by triggering cardiomyocyte autosis	27

Leukocyte cytokine responses in adult patients with mitochondrial DNA defects	26
Valproic acid modulates collagen architecture in the postoperative conjunctival scar	26
Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro	25
DNA origami: a tool to evaluate and harness transcription factors	23
Mesenchymal stem cell–derived extracellular vesicles in periodontal bone repair	23
Correction to: Liquid biopsies for multiple myeloma in a time of precision medicine	23
Retraction Note: Radiation-induced glucocorticoid receptor promotes CD44 + prostate cancer stem cell growth through activation of SGK1-Wnt/β-catenin signaling	23
The role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications	22
The critical role of LRG1 in pathological fibrosis	22
Progress in diagnosis and treatment of Leber’s hereditary optic neuropathy	22
Macrophage co-culture promotes cell reprogramming and prevents ferroptosis in aging fibroblasts for neurodegeneration therapy	22
Rare and low-frequency variants in families with otitis media	21
RNA-Seq for the detection of gene fusions in solid tumors: development and validation of the JAX FusionSeq™ 2.0 assay	21
SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels	20
Vav2 promotes ductus arteriosus anatomic closure via the remodeling of smooth muscle cells by Rac1 activation	20
Targeting ferroptosis for the treatment of female reproductive system disorders	20
The plasma exosomes from patients with primary Sjögren’s syndrome contain epithelial cell–derived proteins involved in ferroptosis	20
Bicuspid aortic valve aortopathy is characterized by embryonic epithelial to mesenchymal transition and endothelial instability	20
Research progress and application of liver organoids for disease modeling and regenerative therapy	19
4-Hydroxychalcone alleviated Angiotensin II-induced atrial fibrillation via immunoproteasome-IKK-NF-κB signaling pathway modulation	19
Correction to: PRMT4 drives post-ischemic angiogenesis via YB1/VEGF signaling	19
Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels	19
Retraction Note: Stabilization of the histone acetyltransferase Tip60 by deubiquitinating enzyme USP7 stimulates the release of pro-inflammatory mediators in acute lung injury	18
Whole genome DNA methylation profiles define Meniere’s disease subclusters	17
Integration of clinical characteristics and molecular signatures of the tumor microenvironment to predict the prognosis of neuroblastoma	17
Circulating extracellular vesicles are associated with pathophysiological condition including metabolic syndrome-related dysmetabolism in children and adolescents with obesity	17
Syncytin-1, syncytin-2 and suppressyn in human health and disease	17
Elucidation of endothelial progenitor cell dysfunction in diabetes by RNA sequencing and constructing lncRNA–miRNA–mRNA competing endogenous RNA network	17
Identification of mutational signature for lung adenocarcinoma prognosis and immunotherapy prediction	16
Transcriptional changes in multiple endocrine organs from lethal cases of COVID-19	16
A bioactive soluble recombinant mouse LIGHT promotes effective tumor immune cell infiltration delaying tumor growth	16
Exploring endothelial dysfunction in major rheumatic diseases: current trends and future directions	16
Systemic and local effect of oxidative stress on recurrent aphthous stomatitis: systematic review	16
Central dopamine receptors: Radiotracers unveiling the Role of dopaminergic tone in obesity	16
Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions	16
FoxO3 and oxidative stress: a multifaceted role in cellular adaptation	15
Extragustatory bitter taste receptors in head and neck health and disease	15
Kielin/chordin-like protein deficiency causes cardiac aging in male mice	15
Dispensable role of Rac1 and Rac3 after cochlear hair cell specification	15
Nischarin expression may have differing roles in male and female melanoma patients	15
Statin therapy protects against abdominal aortic aneurysms by inducing the accumulation of regulatory T cells in ApoE−/− mice	15
Copper chaperone antioxidant 1: multiple roles and a potential therapeutic target	15
Unproductive alternative splicing of ATM exon 7: mapping of critical regulatory elements and identification of 34 spliceogenic variants	15
Large extracellular vesicles derived from human regulatory macrophages (L-EVMreg) attenuate CD3/CD28-induced T-cell activation in vitro	14
Correction to: Matrix metalloproteinase‑7 induces E‑cadherin cleavage in acid‑exposed primary human pharyngeal epithelial cells via the ROS/ERK/c‑Jun pathway	14
Rare variants in cardiomyopathy genes predispose to cardiac injury in severe COVID-19 patients of African or Hispanic ancestry	14
EVs vs. EVs: MSCs and Tregs as a source of invisible possibilities	14
POFUT1 as a cancer biomarker: insights into its oncogenic mechanisms and clinical relevance	14
Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo	14
Abnormal protein SUMOylation in liver disease: novel target for therapy	13

Targeting EphA2: a promising strategy to overcome chemoresistance and drug resistance in cancer	13
Targeted metabolomics reveals tricarboxylic acid cycle-related metabolites serve as predictive biomarkers for trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer	13
The regulatory role of LncRNA HCG18 in various cancers	13
Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells	13
Two-trace two-dimensional correlation spectra (2T2D-COS) analysis using FTIR spectra to monitor the immune response by COVID-19	13
VSMC-specific TRPC1 deletion attenuates angiotensin II-induced hypertension and cardiovascular remodeling	13
Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts	13
EV-T synergizes with AZD5582 to overcome TRAIL resistance through concomitant suppression of cFLIP, MCL-1, and IAPs in hepatocarcinoma	13
Are there foetal extracellular vesicles in maternal blood? Prospects for diagnostic biomarker discovery	13
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma	12
Suppression of PGE2/EP2 signaling alleviates Hirschsprung disease by upregulating p38 mitogen-activated protein kinase activity	12
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder	12
DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis	12
Loss of CAA interruption and intergenerational CAG instability in Chinese patients with Huntington’s disease	12
Nintedanib reduces severity of post-traumatic joint contracture by modulating fibrosis and inflammation	12
Exploring the role of tRNA-derived small RNAs (tsRNAs) in disease: implications for HIF-1 pathway modulation	12
Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice	12
Recent advances in the molecular mechanisms of low-intensity pulsed ultrasound against inflammation	12
Identification of STAT3 and MYC as critical ferroptosis-related biomarkers in septic cardiomyopathy: a bioinformatics and experimental study	12
The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration	12
Lipidomic insights on abdominal aortic aneurysm and peripheral arterial disease	12
Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease	11
Dilated cardiomyopathy in patients with PRDM16 haploinsufficiency	11
Protective role of M3 muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury	11
Etiopathogenesis of medication-related osteonecrosis of the jaws: a review	11
SMARCC1 promotes M2 macrophage polarization and reduces ferroptosis in lung cancer by activating FLOT1 transcription	11
Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation	11
Regulation of innate lymphoid cell by microbial metabolites	11
TIPE2: a novel regulatory factor for cardiovascular-related diseases	10
ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death	10
Correction to: Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function	10
Correction to: Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death	10
Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer	10
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer	10
Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice	10
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases	10
Mitochondria targeted esculetin administration improves insulin resistance and hyperglycemia-induced atherosclerosis in db/db mice	10
Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers	10
The FOXO family of transcription factors: key molecular players in gastric cancer	10
Regulation of wound healing and fibrosis by galectins	10
Correction to: Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14	10
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer	10
NLRC3 attenuates osteoclastogenesis by limiting TNFα+ Th17 cell response in osteoporosis	10
Pkhd1cyli/cyli mice have altered renal Pkhd1 mRNA processing and hormonally sensitive liver disease	10