Journal of Molecular Medicine-Jmm

Article	Citations
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches	107
Endocrine resistance in breast cancer: from molecular mechanisms to therapeutic strategies	57
AMPK: a key regulator of energy stress and calcium-induced autophagy	56
Obesity and its impact on COVID-19	55
Glycosylation is a key in SARS-CoV-2 infection	55
Disturbed lipid and amino acid metabolisms in COVID-19 patients	53
The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis	52
Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions	51
Organoids of the female reproductive tract	49
Non-coding RNAs regulating mitochondrial function in cardiovascular diseases	44
Extracellular vesicles-associated tRNA-derived fragments (tRFs): biogenesis, biological functions, and their role as potential biomarkers in human diseases	43
Evolving AAV-delivered therapeutics towards ultimate cures	43
Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell	42
Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role	41
Genetic engineering in organoids	37
The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis	37
High glucose: an emerging association between diabetes mellitus and cancer progression	36
The human coronaviruses (HCoVs) and the molecular mechanisms of SARS-CoV-2 infection	36
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota	33
Memantine in neurological disorders – schizophrenia and depression	32
High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity	31
Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders	31
NLRP3 inflammasome priming and activation in cholestatic liver injury via the sphingosine 1-phosphate/S1P receptor 2/Gα(12/13)/MAPK signaling pathway	31
Corticosteroid enhances epithelial barrier function in intestinal organoids derived from patients with Crohn’s disease	29
Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer	29

Clinical perspectives on the age-related increase of immunosuppressive activity	27
Multiple sclerosis is linked to MAPKERK overactivity in microglia	27
Nrf2 as a potential target for Parkinson’s disease therapy	26
Mitochondrial dynamics and its impact on human health and diseases: inside the DRP1 blackbox	26
P2X7 receptor: a critical regulator and potential target for breast cancer	26
Lipid accumulation and novel insight into vascular smooth muscle cells in atherosclerosis	25
CD27 expression on Treg cells limits immune responses against tumors	25
The FOXO family of transcription factors: key molecular players in gastric cancer	25
Current and future direction in treatment of HPV-related cervical disease	25
Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance	23
Cooperative signaling between integrins and growth factor receptors in fibrosis	22
Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence	22
The ethics of human-embryoids model: a call for consistency	22
In vivo optical molecular imaging of inflammation and immunity	21
Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR	21
Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1	21
JAK2 regulates paclitaxel resistance in triple negative breast cancers	21
Oviduct as a sensor of embryo quality: deciphering the extracellular vesicle (EV)-mediated embryo-maternal dialogue	21
Somatic non-cancerous PIK3CA-related overgrowth syndrome treated with alpelisib in North America	20
Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway	20
Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways	20
Gaucher disease – more than just a rare lipid storage disease	20
NF-κB in control of regulatory T cell development, identity, and function	20
Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy	19
FoxO3 and oxidative stress: a multifaceted role in cellular adaptation	19
PBX1: a key character of the hallmarks of cancer	19
Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective	18
Dysregulation of circRNA expression in the peripheral blood of individuals with schizophrenia and bipolar disorder	18
An update to “novel therapeutic approaches for treatment of COVID-19”	18
RNA sequencing reveals BMP4 as a basis for the dual-target treatment of diabetic retinopathy	18
The transrepression and transactivation roles of CtBPs in the pathogenesis of different diseases	18
SAMHD1 in cancer: curse or cure?	18
Regional specification and complementation with non-neuroectodermal cells in human brain organoids	18
Expression and function of Smad7 in autoimmune and inflammatory diseases	18
Epigenetic modifications of Klotho expression in kidney diseases	18
Soluble IL-6R-mediated IL-6 trans-signaling activation contributes to the pathological development of psoriasis	18
White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure	17
Epigenetic mechanisms regulate sex-specific bias in disease manifestations	17
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations	17
Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy	17
Roles of E3 ubiquitin ligases in gastric cancer carcinogenesis and their effects on cisplatin resistance	16
Gastrointestinal epithelial innate immunity—regionalization and organoids as new model	16
LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1	16
ZMIZ proteins: partners in transcriptional regulation and risk factors for human disease	16
Mixed lineage kinase domain-like pseudokinase-mediated necroptosis aggravates periodontitis progression	16
Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression	16
Lipid metabolism in idiopathic pulmonary fibrosis: From pathogenesis to therapy	16
Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change	15
Activated microglia–induced neuroinflammatory cytokines lead to photoreceptor apoptosis in Aβ-injected mice	15
c-Met up-regulates the expression of PD-L1 through MAPK/NF-κBp65 pathway	15

Apamin inhibits renal fibrosis via suppressing TGF-β1 and STAT3 signaling in vivo and in vitro	15
ABCB1 in dermatology: roles in skin diseases and their treatment	15
PiRNA pathway in the cardiovascular system: a novel regulator of cardiac differentiation, repair and regeneration	14
Endogenous cortisol excess confers a unique lipid signature and metabolic network	14
Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients	14
Circulating tumor cells in colorectal cancer in the era of precision medicine	14
Mucosal immunity and tRNA, tRF, and tiRNA	14
MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression	14
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma	13
Leukocyte cytokine responses in adult patients with mitochondrial DNA defects	13
Insulin-mediated immune dysfunction in the development of preeclampsia	13
Regulation of endothelial progenitor cell functions during hyperglycemia: new therapeutic targets in diabetic wound healing	13
Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes	13
Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology	13
Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis	13
The role of the individual TOM subunits in the association of PINK1 with depolarized mitochondria	13
The roles of collagen in chronic kidney disease and vascular calcification	13
Histone deacetylase 3 (HDAC3) as an important epigenetic regulator of kidney diseases	13
Deciphering therapeutic options for neurodegenerative diseases: insights from SIRT1	13
Unleashing the power of NK cells in anticancer immunotherapy	13
Copper chaperone antioxidant 1: multiple roles and a potential therapeutic target	13
Recapitulating lipid accumulation and related metabolic dysregulation in human liver-derived organoids	13
Mechanism of METTL14-mediated m6A modification in non-small cell lung cancer cell resistance to cisplatin	12
A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods	12
SUMOylation targeting mitophagy in cardiovascular diseases	12
Exploring the link between chronobiology and drug delivery: effects on cancer therapy	12
Glucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23)	12
Self-organization of organoids from endoderm-derived cells	12
Bone marrow adiposity during pathologic bone loss: molecular mechanisms underlying the cellular events	12
ATF3 in atherosclerosis: a controversial transcription factor	12
The important roles of microRNAs in depression: new research progress and future prospects	11
Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis	11
N-Methyl-D-aspartate receptor activation, novel mechanism of homocysteine-induced blood–retinal barrier dysfunction	11
Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease	11
DUOX1 in mammalian disease pathophysiology	11
GSK-3α aggravates inflammation, metabolic derangement, and cardiac injury post-ischemia/reperfusion	11
Nets, pulmonary arterial hypertension, and thrombo-inflammation	11
AMPKα-like proteins as LKB1 downstream targets in cell physiology and cancer	10
Ziprasidone suppresses pancreatic adenocarcinoma cell proliferation by targeting GOT1 to trigger glutamine metabolism reprogramming	10
Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation	10
PRMT4 drives post-ischemic angiogenesis via YB1/VEGF signaling	10
3D culture conditions support Kaposi’s sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells	10
The role of hypoxia-inducible factor 1α in hepatic lipid metabolism	10
Strategies for simultaneous and successive delivery of RNA	10
Targeted 1H NMR metabolomics and immunological phenotyping of human fresh blood and serum samples discriminate between healthy individuals and inflammatory bowel disease patients treated with anti-TNF	10
Role of non-coding RNA in immune microenvironment and anticancer therapy of gastric cancer	10
Circulating circRNA as biomarkers for dilated cardiomyopathy etiology	10
Epigenetic regulation of Toll-like receptors 2 and 4 in kidney disease	10
Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster	10
Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction	10
Identification of the immune gene expression signature associated with recurrence of high-grade gliomas	9
Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions	9
Cerebral derailment after myocardial infarct: mechanisms and effects of the signaling from the ischemic heart to brain	9
Inhibition of p38 MAPK decreases hyperglycemia-induced nephrin endocytosis and attenuates albuminuria	9
TGF-β1/Smad3 upregulates UCA1 to promote liver fibrosis through DKK1 and miR18a	9
Histone modification in podocyte injury of diabetic nephropathy	9
The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of β-cells	9
HIF2α regulates the synthesis and release of epinephrine in the adrenal medulla	9
Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis	9
Endothelial glycocalyx degradation in multisystem inflammatory syndrome in children related to COVID-19	9
Neurovascular abnormalities in retinopathy of prematurity and emerging therapies	9
Recent advances in the molecular mechanisms of low-intensity pulsed ultrasound against inflammation	9
Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway	9
Nucleophosmin/B23 promotes endometrial cancer cell escape from macrophage phagocytosis by increasing CD24 expression	9
The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori	9
A cell-based drug delivery platform for treating central nervous system inflammation	9
Mitochondrial transplantation as a possible therapeutic option for sarcopenia	9
Genetic modification by overexpression of target gene in mesenchymal stromal cell for treating liver diseases	8
Sterile inflammation in the pathogenesis of maturation failure of arteriovenous fistula	8
TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis	8
Anti-fibrotic effects of pharmacologic FGF-2: a review of recent literature	8
Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases	8
Retinal tissue develops an inflammatory reaction to tobacco smoke and electronic cigarette vapor in mice	8
The regulatory role of LncRNA HCG18 in various cancers	8
Tissue and cell-type-specific transduction using rAAV vectors in lung diseases	8
SUMOylation of Pdia3 exacerbates proinsulin misfolding and ER stress in pancreatic beta cells	8
HSP27 role in cardioprotection by modulating chemotherapeutic doxorubicin-induced cell death	8
Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress–mediated hippocampal damage after myocardial infarction	8
Calorie restriction and breast cancer treatment: a mini-review	8
2,3,5,6-Tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation	8

The therapeutic effect of mesenchymal stem cells in diabetic kidney disease	7
RETRACTED ARTICLE: Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function	7
Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice	7
Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer	7
Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity	7
X-linked genes exhibit miR6891-5p-regulated skewing in Sjögren’s syndrome	7
A novel ceRNA regulatory network involving the long noncoding NEAT1, miRNA-466f-3p and its mRNA target in osteoblast autophagy and osteoporosis	7
The multiple functions of PrPC in physiological, cancer, and neurodegenerative contexts	7
Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects	7
Functional roles of E3 ubiquitin ligases in prostate cancer	7
The mechanisms of exosomes in diabetic foot ulcers healing: a detailed review	7
Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling	7
LMO3 reprograms visceral adipocyte metabolism during obesity	7
I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy	7
Adhesion G protein-coupled receptor gluing action guides tissue development and disease	7
New insights into macrophage subsets in atherosclerosis	7
COVID-19 in multiple-myeloma patients: cellular and humoral immunity against SARS-CoV-2 in a short- and long-term view	7
The diagnostic potential of a circRNA–miRNA network in non-small cell lung cancer	7
The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration	7
Knockdown of SOX9 alleviates tracheal fibrosis through the Wnt/β-catenin signaling pathway	7
Nicotinamide riboside kinase-2 regulates metabolic adaptation in the ischemic heart	7
Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis	6
Regulation of wound healing and fibrosis by galectins	6
Diminished miR-374c-5p negatively regulates IL (interleukin)-6 in unexplained recurrent spontaneous abortion	6
Growth hormone/IGF-I-dependent signaling restores decreased expression of the myokine SPARC in aged skeletal muscle	6
EVs vs. EVs: MSCs and Tregs as a source of invisible possibilities	6
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B2 receptor antagonism	6
Androgen-dependent tissue factor pathway inhibitor regulating protein: a review of its peripheral actions and association with cardiometabolic diseases	6
Sexual dimorphism in cardiac remodeling: the molecular mechanisms ruled by sex hormones in the heart	6
Realizing the potential of organoids—an interview with Hans Clevers	6
Sympathetic nerve-adipocyte interactions in response to acute stress	6
Liquid–liquid phase separation in Alzheimer’s disease	6
mTOR-FABP4 signal is activated in brain arteriovenous malformations in humans	6
G-quadruplexes from non-coding RNAs	6
Uremic mouse model to study vascular calcification and “inflamm-aging”	6
Targets and regulation of microRNA-652-3p in homoeostasis and disease	6
Dysregulation of miRNA-30e-3p targeting IL-1β in an international cohort of systemic autoinflammatory disease patients	6
Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology	6
Endotoxin tolerance and low activation of TLR-4/NF-κB axis in monocytes of COVID-19 patients	6
Recent updates on targeting the molecular mediators of NAFLD	6
WWOX and metabolic regulation in normal and pathological conditions	6
EV-T synergizes with AZD5582 to overcome TRAIL resistance through concomitant suppression of cFLIP, MCL-1, and IAPs in hepatocarcinoma	6
miR profile in pagetic osteoclasts: from large-scale sequencing to gene expression study	6
Genetic abnormalities in biopsy-proven, adult-onset hemolytic uremic syndrome and C3 glomerulopathy	6
A comprehensive review on phytochemicals for fatty liver: are they potential adjuvants?	6
Predictive value of common genetic variants in idiopathic pulmonary fibrosis survival	6
Recessive ciliopathy mutations in primary endocardial fibroelastosis: a rare neonatal cardiomyopathy in a case of Alstrom syndrome	5
RNA-Seq for the detection of gene fusions in solid tumors: development and validation of the JAX FusionSeq™ 2.0 assay	5
Progranulin, a moderator of estrogen/estrogen receptor α binding, regulates bone homeostasis through PERK/p-eIF2 signaling pathway	5
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases	5
The role of immunosuppressive myofibroblasts in the aging process and age-related diseases	5
The mutual interplay of redox signaling and connexins	5
Targeting EphA2: a promising strategy to overcome chemoresistance and drug resistance in cancer	5
TREM-2 mediates dendritic cell–induced NO to suppress Th17 activation and ameliorate chronic kidney diseases	5
CARMA1 is required for Notch1-induced NF-κB activation in SIL-TAL1-negative T cell acute lymphoblastic leukemia	5
A multitarget angiogenesis inhibitor, CTT peptide-endostatin mimic-kringle 5, prevents diet-induced obesity	5
Serum exosomal coronin 1A and dynamin 2 as neural tube defect biomarkers	5
The role of CDHR3 in susceptibility to otitis media	5
Human colorectal cancer-associated carbohydrate antigen on annexin A2 protein	5
Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation	5
CTHRC1 promotes colorectal cancer progression by recruiting tumor-associated macrophages via up-regulation of CCL15	5
Molecular therapy of cardiac ischemia–reperfusion injury based on mitochondria and ferroptosis	5
Kielin/chordin-like protein deficiency causes cardiac aging in male mice	5
Phase separation in immune regulation and immune-related diseases	5
Predisposition to Graves’ disease and Graves’ ophthalmopathy by genetic variants of IL2RA	5
ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and dissection in mice	5
ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death	5
Advances in gene therapy for neurogenetic diseases: a brief review	5
Galectin-3 and soluble RAGE as new biomarkers of post-infarction cardiac remodeling	5
Molecular characterization of ctDNA from Chinese patients with advanced gastric adenocarcinoma reveals actionable alterations for targeted and immune therapy	5
HIF-1 mediated activation of antimicrobial peptide LL-37 in type 2 diabetic patients	5
Ataluren suppresses a premature termination codon in an MPS I-H mouse	5
Blocking prokineticin receptors attenuates synovitis and joint destruction in collagen-induced arthritis	4
Insufficient SIRT1 in macrophages promotes oxidative stress and inflammation during scarring	4
The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype	4
LAMP2A regulates the balance of mesenchymal stem cell adipo-osteogenesis via the Wnt/β-catenin/GSK3β signaling pathway	4
IGFBP2 function as a novel biomarker for active lupus nephritis	4
The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis	4
Melatonin inhibits senescence-associated melanin pigmentation through the p53-TYR pathway in human primary melanocytes and the skin of C57BL/6 J mice after UVB irradiation	4
Silencing of Mcl-1 overcomes resistance of melanoma cells against TRAIL-armed oncolytic adenovirus by enhancement of apoptosis	4
Statin therapy protects against abdominal aortic aneurysms by inducing the accumulation of regulatory T cells in ApoE−/− mice	4
Spinal fluid IgG antibodies from patients with demyelinating diseases bind multiple sclerosis-associated bacteria	4
Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A	4
Clarithromycin impairs tissue-resident memory and Th17 responses to macrolide-resistant Streptococcus pneumoniae infections	4
Synthetic polypeptide crotamine: characterization as a myotoxin and as a target of combinatorial peptides	4
Novel insights into the nervous system affected by prolonged hyperglycemia	4
MyD88 in hepatic stellate cells promotes the development of alcoholic fatty liver via the AKT pathway	4
Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization	4
Clinical significance of mutational variants in beta and alpha genes in patients with hemoglobinopathies from two large Greek centers: a complex interplay between genotype and phenotype	4
A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane	4
Circular RNAs: regulators of vascular smooth muscle cells in cardiovascular diseases	4
Acid-sensing ion channel 1a exacerbates renal ischemia–reperfusion injury through the NF-κB/NLRP3 inflammasome pathway	4
Molecular evidence for a clonal relationship between synchronous uterine endometrioid carcinoma and ovarian clear cell carcinoma: a new example of “precursor escape”?	4
Loss of CAA interruption and intergenerational CAG instability in Chinese patients with Huntington’s disease	4
Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis	4