Journal of Molecular Medicine-Jmm

Article	Citations
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches	76
Mitigating off-target effects in CRISPR/Cas9-mediated in vivo gene editing	61
Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases	57
ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease	55
The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells	54
Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein	52
Glycosylation is a key in SARS-CoV-2 infection	48
The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis	44
Cancer research using organoid technology	44
AMPK: a key regulator of energy stress and calcium-induced autophagy	43
Expanding and validating the biomarkers for mitochondrial diseases	43
Disturbed lipid and amino acid metabolisms in COVID-19 patients	42
SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1α	40
A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia	40
COVID-19: molecular diagnostics overview	40
Organoids of the female reproductive tract	40
Evolving AAV-delivered therapeutics towards ultimate cures	39
Obesity and its impact on COVID-19	37
Endocrine resistance in breast cancer: from molecular mechanisms to therapeutic strategies	37
Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions	37
Insights into the biased activity of dextromethorphan and haloperidol towards SARS-CoV-2 NSP6: in silico binding mechanistic analysis	35
Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role	34
Lysosomal storage diseases: current therapies and future alternatives	34
Diagnosing the novel SARS-CoV-2 by quantitative RT-PCR: variations and opportunities	33
Novel therapeutic approaches for treatment of COVID-19	33

Genetic engineering in organoids	32
ACE polymorphisms and COVID-19-related mortality in Europe	32
High glucose: an emerging association between diabetes mellitus and cancer progression	31
The human coronaviruses (HCoVs) and the molecular mechanisms of SARS-CoV-2 infection	31
Neutralization of extracellular NAMPT (nicotinamide phosphoribosyltransferase) ameliorates experimental murine colitis	31
Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis	31
Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregul	31
Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell	31
Extracellular vesicles-associated tRNA-derived fragments (tRFs): biogenesis, biological functions, and their role as potential biomarkers in human diseases	31
The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis	31
TCF21: a critical transcription factor in health and cancer	30
Immuno-epidemiology and pathophysiology of coronavirus disease 2019 (COVID-19)	28
NLRP3 inflammasome priming and activation in cholestatic liver injury via the sphingosine 1-phosphate/S1P receptor 2/Gα(12/13)/MAPK signaling pathway	28
Stress-mediated generation of deleterious ROS in healthy individuals - role of cytochrome c oxidase	28
Oxidized LDL induces vimentin secretion by macrophages and contributes to atherosclerotic inflammation	27
Memantine in neurological disorders – schizophrenia and depression	27
Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke	27
Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer	26
High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity	25
Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders	25
Sex differences on adipose tissue remodeling: from molecular mechanisms to therapeutic interventions	24
The FOXO family of transcription factors: key molecular players in gastric cancer	23
Mitochondrial dynamics and its impact on human health and diseases: inside the DRP1 blackbox	23
CD27 expression on Treg cells limits immune responses against tumors	23
Non-coding RNAs regulating mitochondrial function in cardiovascular diseases	23
Nrf2 as a potential target for Parkinson’s disease therapy	22
P2X7 receptor: a critical regulator and potential target for breast cancer	22
Corticosteroid enhances epithelial barrier function in intestinal organoids derived from patients with Crohn’s disease	21
Wnt signaling in kidney: the initiator or terminator?	20
The anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer	20
Multiple sclerosis is linked to MAPKERK overactivity in microglia	20
hPSC-derived organoids: models of human development and disease	20
Current and future direction in treatment of HPV-related cervical disease	20
Lipid accumulation and novel insight into vascular smooth muscle cells in atherosclerosis	20
Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance	20
NLRP6 contributes to inflammation and brain injury following intracerebral haemorrhage by activating autophagy	19
Impact of β-glycerophosphate on the bioenergetic profile of vascular smooth muscle cells	19
Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target	19
3D kidney organoids for bench-to-bedside translation	19
Differential regulation of osteopontin and CD44 correlates with infertility status in PCOS patients	18
Liquid biopsies for multiple myeloma in a time of precision medicine	18
Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence	18
An update to “novel therapeutic approaches for treatment of COVID-19”	18
Cooperative signaling between integrins and growth factor receptors in fibrosis	18
Toll-interacting protein impacts on inflammation, autophagy, and vacuole trafficking in human disease	18
The ethics of human-embryoids model: a call for consistency	17
Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway	17
In vivo optical molecular imaging of inflammation and immunity	17
Epigenetic modifications of Klotho expression in kidney diseases	17
Exploring the VISTA of microglia: immune checkpoints in CNS inflammation	17

Somatic non-cancerous PIK3CA-related overgrowth syndrome treated with alpelisib in North America	16
Signaling lipids as diagnostic biomarkers for ocular surface cicatrizing conjunctivitis	16
Dysregulation of circRNA expression in the peripheral blood of individuals with schizophrenia and bipolar disorder	16
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations	16
Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways	16
Clinical perspectives on the age-related increase of immunosuppressive activity	16
RNA sequencing reveals BMP4 as a basis for the dual-target treatment of diabetic retinopathy	16
JAK2 regulates paclitaxel resistance in triple negative breast cancers	16
Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1	16
Oviduct as a sensor of embryo quality: deciphering the extracellular vesicle (EV)-mediated embryo-maternal dialogue	16
The transrepression and transactivation roles of CtBPs in the pathogenesis of different diseases	16
Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR	15
The herbal extract EPs® 7630 increases the antimicrobial airway defense through monocyte-dependent induction of IL-22 in T cells	15
PBX1: a key character of the hallmarks of cancer	15
Need for a precise molecular diagnosis in Beckwith-Wiedemann and Silver-Russell syndrome: what has to be considered and why it is important	15
Phenotypic characteristics of commonly used inbred mouse strains	15
CU06-1004 (endothelial dysfunction blocker) ameliorates astrocyte end-feet swelling by stabilizing endothelial cell junctions in cerebral ischemia/reperfusion injury	14
Expression and function of Smad7 in autoimmune and inflammatory diseases	14
MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression	14
The impact of DNA demethylation on the upregulation of the NRN1 and TNFAIP3 genes associated with advanced gastric cancer	14
Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression	14
Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy	14
Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis	14
HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD	14
Epigenetic mechanisms regulate sex-specific bias in disease manifestations	14
Immune landscape and a novel immunotherapy-related gene signature associated with clinical outcome in early-stage lung adenocarcinoma	14
ABCB1 in dermatology: roles in skin diseases and their treatment	14
Regional specification and complementation with non-neuroectodermal cells in human brain organoids	13
Gastrointestinal epithelial innate immunity—regionalization and organoids as new model	13
LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1	13
Gaucher disease – more than just a rare lipid storage disease	13
HMGB1: an important regulator of myeloid differentiation and acute myeloid leukemia as well as a promising therapeutic target	13
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota	13
SAMHD1 in cancer: curse or cure?	13
TNFSF13 upregulation confers chemotherapeutic resistance via triggering autophagy initiation in triple-negative breast cancer	13
TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells	13
Soluble IL-6R-mediated IL-6 trans-signaling activation contributes to the pathological development of psoriasis	13
The therapeutic potential of Aurora kinases targeting in glioblastoma: from preclinical research to translational oncology	12
ZMIZ proteins: partners in transcriptional regulation and risk factors for human disease	12
Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes	12
Roles of E3 ubiquitin ligases in gastric cancer carcinogenesis and their effects on cisplatin resistance	12
Histone deacetylase 3 (HDAC3) as an important epigenetic regulator of kidney diseases	12
Circulating tumor cells in colorectal cancer in the era of precision medicine	12
Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients	12
Critical role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas	12
Endogenous cortisol excess confers a unique lipid signature and metabolic network	12
Pyruvate dehydrogenase kinase/lactate axis: a therapeutic target for neovascular age-related macular degeneration identified by metabolomics	12
Stem cell therapies for retinal diseases: from bench to bedside	11
Mixed lineage kinase domain-like pseudokinase-mediated necroptosis aggravates periodontitis progression	11
Exploring the link between chronobiology and drug delivery: effects on cancer therapy	11
Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change	11
Unleashing the power of NK cells in anticancer immunotherapy	11
Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models	11
Mucosal immunity and tRNA, tRF, and tiRNA	11
Relevance of iNOS expression in tumor growth and maintenance of cancer stem cells in a bladder cancer model	11
Apamin inhibits renal fibrosis via suppressing TGF-β1 and STAT3 signaling in vivo and in vitro	11
Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy	11
Gut microbiota and atherosclerosis: role of B cell for atherosclerosis focusing on the gut-immune-B2 cell axis	11
A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods	11
Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis	11
The role of the individual TOM subunits in the association of PINK1 with depolarized mitochondria	10
Identification of the immune gene expression signature associated with recurrence of high-grade gliomas	10
White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure	10
Critical roles of macrophages in pressure overload-induced cardiac remodeling	10
Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine	10
Insulin-mediated immune dysfunction in the development of preeclampsia	10
3D culture conditions support Kaposi’s sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells	10
Glucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23)	10
c-Met up-regulates the expression of PD-L1 through MAPK/NF-κBp65 pathway	10
Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis	10
Microparticles expressing myeloperoxidase as potential biomarkers in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV)	10
Treatment of murine colitis by Saccharomyces boulardii secreting atrial natriuretic peptide	10
Bone marrow adiposity during pathologic bone loss: molecular mechanisms underlying the cellular events	10
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations	10
Revisiting lactate dynamics in cancer—a metabolic expertise or an alternative attempt to survive?	10
Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity	10
Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes	9
PiRNA pathway in the cardiovascular system: a novel regulator of cardiac differentiation, repair and regeneration	9
The important roles of microRNAs in depression: new research progress and future prospects	9
Self-organization of organoids from endoderm-derived cells	9

Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions	9
HIF2α regulates the synthesis and release of epinephrine in the adrenal medulla	9
Endothelial glycocalyx degradation in multisystem inflammatory syndrome in children related to COVID-19	9
Local Wnt3a treatment restores bone regeneration in large osseous defects after surgical debridement of osteomyelitis	9
Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor β1	9
Leukocyte immunoglobulin-like receptor B4 protects against cardiac hypertrophy via SHP-2-dependent inhibition of the NF-κB pathway	9
Recapitulating lipid accumulation and related metabolic dysregulation in human liver-derived organoids	9
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma	9
Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease	9
N-Methyl-D-aspartate receptor activation, novel mechanism of homocysteine-induced blood–retinal barrier dysfunction	9
Sars-Cov-2 interference in HEME production: is it the time for an early predictive biomarker?	9
AMPKα-like proteins as LKB1 downstream targets in cell physiology and cancer	9
The roles of collagen in chronic kidney disease and vascular calcification	9
Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology	9
Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation	9
Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective	8
Human carnosinase 1 overexpression aggravates diabetes and renal impairment in BTBROb/Ob mice	8
Circulating circRNA as biomarkers for dilated cardiomyopathy etiology	8
ATF3 in atherosclerosis: a controversial transcription factor	8
Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress–mediated hippocampal damage after myocardial infarction	8
Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner	8
NF-κB in control of regulatory T cell development, identity, and function	8
Regulation of endothelial progenitor cell functions during hyperglycemia: new therapeutic targets in diabetic wound healing	8
PRMT4 drives post-ischemic angiogenesis via YB1/VEGF signaling	7
Epigenetic regulation of Toll-like receptors 2 and 4 in kidney disease	7
Inhibition of p38 MAPK decreases hyperglycemia-induced nephrin endocytosis and attenuates albuminuria	7
Strategies for simultaneous and successive delivery of RNA	7
Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster	7
Nets, pulmonary arterial hypertension, and thrombo-inflammation	7
Histone modification in podocyte injury of diabetic nephropathy	7
Retinal tissue develops an inflammatory reaction to tobacco smoke and electronic cigarette vapor in mice	7
Activated microglia–induced neuroinflammatory cytokines lead to photoreceptor apoptosis in Aβ-injected mice	7
SUMOylation targeting mitophagy in cardiovascular diseases	7
Cerebral derailment after myocardial infarct: mechanisms and effects of the signaling from the ischemic heart to brain	7
Deciphering therapeutic options for neurodegenerative diseases: insights from SIRT1	7
Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling	7
I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy	7
Targeting TJP1 attenuates cell–cell aggregation and modulates chemosensitivity against doxorubicin in leiomyosarcoma	7
Sterile inflammation in the pathogenesis of maturation failure of arteriovenous fistula	7
The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of β-cells	7
Mechanism of METTL14-mediated m6A modification in non-small cell lung cancer cell resistance to cisplatin	7
Tissue and cell-type-specific transduction using rAAV vectors in lung diseases	7
A cell-based drug delivery platform for treating central nervous system inflammation	7
GSTM1 null and GSTT1 null: predictors of cisplatin-caused acute ototoxicity measured by DPOAEs	7
Neurovascular abnormalities in retinopathy of prematurity and emerging therapies	7
DUOX1 in mammalian disease pathophysiology	7
Genetic modification by overexpression of target gene in mesenchymal stromal cell for treating liver diseases	7
HSP27 role in cardioprotection by modulating chemotherapeutic doxorubicin-induced cell death	6
EV-T synergizes with AZD5582 to overcome TRAIL resistance through concomitant suppression of cFLIP, MCL-1, and IAPs in hepatocarcinoma	6
Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects	6
Role of non-coding RNA in immune microenvironment and anticancer therapy of gastric cancer	6
FoxO3 and oxidative stress: a multifaceted role in cellular adaptation	6
Realizing the potential of organoids—an interview with Hans Clevers	6
TGF-β1/Smad3 upregulates UCA1 to promote liver fibrosis through DKK1 and miR18a	6
Expression of long pentraxin 3 in human nasal mucosa fibroblasts, tissues, and secretions of chronic rhinosinusitis without nasal polyps	6
De novo mutation of cancer-related genes associates with particular neurodevelopmental disorders	6
The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance	6
RETRACTED ARTICLE: Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function	6
Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice	6
COVID-19 in multiple-myeloma patients: cellular and humoral immunity against SARS-CoV-2 in a short- and long-term view	6
Nucleophosmin/B23 promotes endometrial cancer cell escape from macrophage phagocytosis by increasing CD24 expression	6
Leukocyte cytokine responses in adult patients with mitochondrial DNA defects	6
SUMOylation of Pdia3 exacerbates proinsulin misfolding and ER stress in pancreatic beta cells	6
Targeted 1H NMR metabolomics and immunological phenotyping of human fresh blood and serum samples discriminate between healthy individuals and inflammatory bowel disease patients treated with anti-TNF	6
Targets and regulation of microRNA-652-3p in homoeostasis and disease	6
Genetic abnormalities in biopsy-proven, adult-onset hemolytic uremic syndrome and C3 glomerulopathy	6
Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway	6
Ziprasidone suppresses pancreatic adenocarcinoma cell proliferation by targeting GOT1 to trigger glutamine metabolism reprogramming	6
Synergistic effects of pazopanib and hyperthermia against uterine leiomyosarcoma growth mediated by downregulation of histone acetyltransferase 1	6
Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity	6
Enhancers and MYC interplay in hematopoiesis	6
Diminished miR-374c-5p negatively regulates IL (interleukin)-6 in unexplained recurrent spontaneous abortion	5
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B2 receptor antagonism	5
A multitarget angiogenesis inhibitor, CTT peptide-endostatin mimic-kringle 5, prevents diet-induced obesity	5
Progranulin, a moderator of estrogen/estrogen receptor α binding, regulates bone homeostasis through PERK/p-eIF2 signaling pathway	5
Bax inhibitor-1 deficiency leads to obesity by increasing Ca2+-dependent insulin secretion	5
Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis	5
Fetal programming effects of pentaerythritol tetranitrate in a rat model of superimposed preeclampsia	5
Galectin-3 and soluble RAGE as new biomarkers of post-infarction cardiac remodeling	5
Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation	5
A comprehensive review on phytochemicals for fatty liver: are they potential adjuvants?	5
CARMA1 is required for Notch1-induced NF-κB activation in SIL-TAL1-negative T cell acute lymphoblastic leukemia	5
Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology	5
2,3,5,6-Tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation	5
Molecular karyotyping and gene expression analysis in childhood cancer patients	5
Knockdown of SOX9 alleviates tracheal fibrosis through the Wnt/β-catenin signaling pathway	5
Sympathetic nerve-adipocyte interactions in response to acute stress	5
Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis	5
Molecular characterization of ctDNA from Chinese patients with advanced gastric adenocarcinoma reveals actionable alterations for targeted and immune therapy	5
RETRACTED ARTICLE: Stabilization of the histone acetyltransferase Tip60 by deubiquitinating enzyme USP7 stimulates the release of pro-inflammatory mediators in acute lung injury	5
Lipid metabolism in idiopathic pulmonary fibrosis: From pathogenesis to therapy	5
Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis	5
Functional roles of E3 ubiquitin ligases in prostate cancer	5
Human colorectal cancer-associated carbohydrate antigen on annexin A2 protein	5
The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration	5