OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Clinical Pharmacology and Therapeutics is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Research progress in targeted therapies for gastric cancer	27
Search for nutritional and inflammatory marker ratios to predict neutropenia in FEC therapy for breast cancer: A retrospective observational study	19
Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study	11
Potential drug-drug interactions in a multi-center study of death cases of COVID-19: The significance of appropriate drug choice	10
A decision tree model for predicting high mono-N-desethylamiodarone concentrations and reducing tissue toxicity in patients with low-dose amiodarone therapy: A multicentral retrospective cohort study	8
Post-marketing safety concerns with montelukast: A pharmacovigilance study based on the FDA adverse event reporting system	8
Activated charcoal helps in the diagnosis of dabigatran overdose: A case study	7
Comparison of the efficacy and safety of tofacitinib and mavrilimumab in patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials	7
Association between ABCB1 C3435T polymorphism and antiepileptic drug resistance in epilepsy: An updated meta-analysis based on 62 studies	6
Adverse event profiles of drugs used for treatment of juvenile idiopathic arthritis according to spontaneous reporting system database	6
A cross-sectional study on the potential drug-drug interaction risk of COVID-19 patients in hospital	6
Network pharmacology analysis and clinical efficacy of the traditional Chinese medicine Bu-Shen-Jian-Pi. Part 2: Modulation of hypoxia, redox status, and mitochondrial protection in a neuroblastoma ce	6
Severe drug-induced immune hemolytic anemia due to cefmetazole: A case report	5
Methotrexate for treating polymyalgia rheumatica: A meta-analysis of randomized controlled trials	5
Analysis based on Monte Carlo simulation: How effective is tigecycline in routine antimicrobial therapy?	5
Effects of iguratimod in the treatment of palindromic rheumatism: Case report	5
Self-reported urinary urgency in association with vitamin D and psychiatric symptoms among patients with musculoskeletal pain	5
Drug-induced hepatotoxicity linked to zoledronic acid in the treatment of an elderly man with primary osteoporosis	5
Interferon α-induced lupus-like reaction in a mycosis fungoides patient: A case report	5
Cost-utility analysis of pembrolizumab versus nivolumab in the treatment of metastatic colorectal cancer from the perspective of the healthcare payer	4
Factors affecting outcome in hospitalized patients treated according to recommendations from clinical pharmacologists	4
Methylobacterium infection-induced peritonitis in a patient with renal insufficiency: A case report and literature review	4
Drug-drug interaction between remdesivir and immunosuppressant agents in a kidney transplant recipient	4
Safety profile of carbapenems: Data mining of the FDA adverse events reporting system	4
Sodium-glucose cotransporter-2 inhibitor treatment has differential effects on the incidence of various malignancies: Evidence from a spontaneous adverse reaction database	4

Pegylated-interferon alpha (PEG-IFNα)-induced interstitial lung disease in a patient with chronic hepatitis B: A case report and literature review	4
Retrospective evaluation of medical information for predicting tazobactam/piperacillin-induced liver injury	4
Metformin alone and in combination with sitagliptin induces depression and impairs quality of life in type 2 diabetes mellitus patients: An observational study	3
Comparative efficacy and safety of topiroxostat at different dosages in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials	3
Elevation of serum creatine kinase induced by anti-thyroid drugs: Two case reports and a literature review	3
COVID-19: Effect-modelling of vaccination in Germany with regard to the mutant strain B.1.1.7 and occupancy of ICU facilities	3
Degree of serum LDL cholesterol reduction by simvastatin and ezetimibe is dependent on baseline LDL cholesterol concentration but not on baseline values and changes in cholesterol synthesis and absorp	3
Pharmacokinetics, safety, and bioequivalence of apixaban tablets in healthy Chinese subjects under fasting and fed conditions	3
Pharmacokinetics and bioequivalence study of two ciprofloxacin hydrochloride tablets in healthy Chinese subjects under fasting and fed conditions: A randomized, open-label, two-formulation, two-sequen	3
Sub-therapeutic trimethoprim and sulfamethoxazole plasma concentrations during continuous venovenous hemofiltration in a patient with COVID-19 and pulmonary Pneumocystis jirovecii co-infection: A case	3
Prevalence of and factors associated with the prescription of phytopharmaceuticals in outpatients with urinary tract infections	3
Bleeding events associated with recombinant human soluble thrombomodulin, classified according to renal function, in sepsis-induced disseminated intravascular coagulation	3
Components in Prunus mume and their targets in the alleviation of severe depression identified using network pharmacology analysis	3
High-dose ulinastatin reduces postoperative bleeding and provides platelet-protective effects in patients undergoing heart valve replacement surgery	3
Imipenem cilastatin sodium-associated thrombocytopenia in an older patient: A case report and literature review	3
Tocilizumab: A retrospective multi-center cohort study of critically ill patients with COVID-19	3
Deprescribing proton pump inhibitors: A study in hospitalized patients in Slovenia	3
Activated charcoal can be used to aid the diagnosis of an overdose of dabigatran etexilate	3
Pharmacokinetic comparison between tablet of varenicline tartrate and orally disintegrating film of varenicline salicylate in healthy subjects	3
COVID-19 pandemic management using the 14-day projected incidence	3
Pharmacokinetic and bioequivalence of lenalidomide in multiple myeloma patients	2
Can a β-glucan-containing orthomolecular agent (Saccharomyces sp.) containing metabolic cofactors attenuate cytokine activation and alleviate hypoxia in COVID-19 patients?	2
Pharmacokinetics and bioequivalence of tofacitinib 5 mg in healthy Korean male subjects	2
Topics in focus 2025 The International Journal of Clinical Pharmacology and Therapeutics	2
CYP51A1 polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant	2
Network target theory and network pharmacology: Next generation drug research in medicine using AI models	2
Improving the long-term response to antidepressants by establishing an individualized platform based on variability and chronotherapy	2
Intrathecal drug-infusion system for treating pain in advanced cancer: New research in patient management	2
Warfarin pharmacokinetics and pharmacodynamics are not affected by concomitant administration of the long-acting GLP-1 receptor agonist polyethylene glycol loxenatide	2
Pharmacokinetics and pharmacodynamics of amiodarone in patients with hypertriglyceridemia: Two case reports	2
Comparison of the efficacy and safety of tocilizumab, sarilumab, and sirukumab in comparison with adalimumab as monotherapy in patients with active rheumatoid arthritis: A Bayesian network meta-analys	2
Bioequivalence study of two formulations of afatinib dimaleate tablets in healthy subjects under fasting conditions: A randomized, open-label, single-dose, crossover trial	2
Risks of malignant lymphoma in rheumatoid arthritis patients receiving methotrexate-alone and in combination therapy compared with the general population: A study based on a Japanese medical claims da	2
Prevalence of therapeutic drug monitoring and adherence to imatinib in chronic myeloid leukemia in Japan	2
Association of gynecomastia with antidiabetic medications in older adults: Data mining from different national pharmacovigilance databases	2
Sodium-glucose cotransporter 2 (SGLT2) inhibitors, as potential (off-label) anti-obesity agents and effects on cardiovascular risk: A systematic review and meta-analysis	2
Analysis of risk factors for hypoglycemia in patients with gastrointestinal bleeding induced by somatostatin for injection and establishment of the prediction model	2
Hypersensitivity reaction to high-dose methotrexate and methotrexate-induced acral erythema in a child with acute lymphoblastic leukemia	2
Severe genital cutaneous toxicity with sunitinib	2
Clinical effects of atomizing inhalation of antibiotics on germ clearance rate and adverse reactions in respiratory infectious diseases: A meta-analysis	2
Aplastic anemia associated with osimertinib: Analysis of the FDA adverse event reporting system	2
Securing a diagnosis in patients presenting with suspected paracetamol (acetaminophen) poisoning: A retrospective cohort study	2
Evaluation of the risk factors for the failure of a single prophylactic dose of anticholinergic drugs for irinotecan-induced cholinergic symptoms	2
Duodenal perforation caused by imatinib mesylate during adjuvant treatment of gastric stromal tumor: Case report	2
Is compressed colchicine tablet superior to other colchicine preparations in patients with familial Mediterranean fever?	2
Bisphosphonates in combination with alendronate sodium increase bone mineral density and modulate IL-6, TNF-α, and IGF-1 in patients with osteoporosis	2
Successful management of tumor necrosis factor-alpha inhibitor-induced Sweet syndrome in a patient with ulcerative colitis: A case report	2
Pharmacology of repair after peripheral nerve injury	2
Analgesia with reduced incidence of adverse reactions using flurbiprofen axetil in combination with half standard-dose opioids in primary total knee arthroplasty	2
The International Journal of Clinical Pharmacology and Therapeutics: Medical-scientific publishing tradition with adaptability, innovation, and momentum	2

Bioavailability study of Enoxaparin Sodium Chemi (80 mg/0.8 mL) and Clexane (80 mg/0.8 mL) subcutaneous injection in healthy adults	2
Randomized, open-label, crossover trial comparing the pharmacokinetic profile of a novel oral aspirin solution and a chewed aspirin tablet	2
Benefits of immunoglobulin substitution in primary and secondary immunodeficiencies: Interim analysis of a prospective, long-term non-interventional study	2
Pharmacokinetic evaluation and relative bioavailability pilot study of fidaxomicin in healthy Chinese subjects: An open, randomized, single-dose, cross-over study	2
Severe autoimmune hemolytic anemia associated with glucose-6-phosphate dehydrogenase deficiency as a complication of nivolumab treatment: A case report	2
Prediction of hyperkalemia occurrence in patients using co-trimoxazole: Clinical adjustment of a Markov model	1
A randomized, double-blind, three-arm, parallel group, single-dose phase I study to evaluate the pharmacokinetic similarity between SB12 (a proposed eculizumab biosimilar) and eculizumab (Soliris) in	1
Lemborexant add-on further improves the effect of galantamine on sleepwake disorder in Alzheimer’s disease	1
Advantages of an abdominal anticoagulant subcutaneous injection procedure based on a personal digital assistant and positioning card system: A clinical trial with a historical control cohort	1
An HPLC-MS/MS method for determination of sulbactam in human plasma and its pharmacokinetic application in critically ill patients with augmented renal clearance	1
Evaluation of the comparative pharmacokinetic properties of a new orally disintegrating tablet of tegoprazan in healthy Korean subjects	1
Increased pharmacy purchases of cardiovascular drugs from wholesalers prior to the first and second COVID-19 lockdowns	1
A pharmacokinetic analysis of amisulpride in adult Chinese patients with schizophrenia: Impact of creatinine clearance	1
Evidence that anticoagulant use decreases in-hospital deaths in patients with new-onset atrial fibrillation	1
Longevity – via traditional Chinese medicine and macrobiotics to AI-driven network pharmacology and clinical pharmacology	1
Atovaquone-induced thrombocytopenia: A case report	1
A case of a geriatric patient with thrombocytopenia after partial recovery from COVID-19	1
Clinical Handbook of Psychotropic Drugs for Children and Adolescents (5th Edition)	1
Can non-renal clearance and/or bioavailability of drugs be assessed reliably in renal impairment studies with oral drug administration?	1
Comparison of the acid suppression effects between low-dose esomeprazole and famotidine in healthy subjects	1
Subcutaneous infliximab CT-P13 without intravenous induction in psoriatic arthritis: A case report and pharmacokinetic considerations	1
Comparative efficacy and safety of secukinumab 75 mg, 150 mg, and 300 mg in patients with active ankylosing spondylitis	1
Microdialysis as a potential tool for comparative assessment of tissue pharmacokinetics of two different patches containing lidocaine: A crossover pilot study	1
Network pharmacology analysis and molecular docking using the Chinese herbal agent WYHX formula (according to Yan Dexin): Management of coronary artery disease	1
Augmented renal clearance in neurosurgical patients receiving vancomycin: Limited prognostic value for the duration of hospitalization, treatment course, fever, and changes in the CSF test and CRP	1
Population pharmacokinetics of meropenem among post-operative patients in Pakistan	1
Effects of reduced edoxaban administration on bleeding risk and D-dimer levels in patients wearing elastic stockings after total hip arthroplasty: A retrospective cohort study	1
Evaluation of the representativeness of the German Oncology Dynamics dataset	1
Evaluating real-world data in COVID-19 antigen and PCR testing	1
Does methotrexate use increase the risk of dementia in patients with rheumatoid arthritis?	1
Differentiation of bone marrow mesenchymal stem cells modulated by Bushen Tian Sui decoction via the TGF-β1-Smad2/3 signaling pathway: In vitro evidence and potential clinical application in delayed f	1
Association between first-step analgesic use and cancer in patients with diabetes	1
Inotersen and severe thrombocytopenia: 2 case reports and review	1
H1 antihistamine-induced adverse events and time to onset: A retrospective analysis using the Japanese Adverse Drug Event Report Database	1
Nocebo effects of Janus kinase inhibitors in the treatment of active ankylosing spondylitis	1
Neonatal pain score after use of paracetamol: Is there a relationship with serum trough concentration at steady state in preterm and term neonates?	1
Safety profiles of new xanthine oxidase inhibitors: A post-marketing study	1
Treatment of delayed fracture healing with Bushen Tiansui decoction: Analysis of active agents and targets using bioinformatics and network pharmacology analysis	1
Nocebo responses in randomized controlled trials of COVID-19 vaccines	1
Ocular myasthenia gravis-like symptoms associated with erenumab: Case report	1
Application of low-dose etomidate combined with oxycodone and midazolam in endoscopic injection sclerotherapy	1
Alleviation of renal ischemia-reperfusion injury by quercetin, kaempferol, and myricetin in Shiwei Hezi pill (SHP): Network pharmacology and molecular docking analysis of a traditional Tibetan herbal	1
An unusual case of acute myopericarditis after the first dose of capecitabine: Need for new cardioprotective strategies and risk stratification	1
Acute myeloid leukemia after 10 years of azathioprine treatment for Crohn’s disease	1
Low albumin combined with low-molecular-weight heparin as risk factors for liver injury using azvudine: Evidence from an analysis of COVID-19 patients in a national prospective pharmacovigilance datab	1
Use of mobile phone applications (apps) in preventing drug-drug interactions: A cross-sectional evaluation in a clinical setting in South India	1
Comparative efficacy and safety of etanercept biosimilars in comparison with etanercept in patients with rheumatoid arthritis who have insufficient response to methotrexate: A network meta-analysis	1
Bioequivalence of daclatasvir hydrochloride tablets in healthy Chinese subjects	1
Chronic myeloid leukemia in an ulcerative colitis patient receiving azathioprine: A case report	1
The association between alphablockers in the treatment of benign prostatic hyperplasia and heart failure: A nationwide population-based cohort study in South Korea	1
Effect of infusion time of intravenous acetaminophen on blood pressure in the intensive care unit	1
Hyperammonemia-induced impaired consciousness following mFOLFOX6 therapy in a patient with recurrent rectal cancer	1
Demographic and clinical characteristics of primary care patients vaccinated against COVID-19 in spring 2021	1
Primary and secondary prevention of stroke and cardiovascular events using evolocumab and alirocumab: Meta-analysis of randomized controlled trials	1
Favipiravir pharmacokinetics in COVID-19 patients with moderate to severe kidney dysfunction: Lessons learned	1
Evaluation of polypharmacy among chronic kidney disease patients in Egypt: A cross-sectional study	1
Drug-drug interactions between acenocoumarol and proton pump inhibitors in hospitalized patients: Overanticoagulation associated with intravenous omeprazole	1
Efficacy and safety of antiplatelet therapy in COVID-19: Insights from a meta-analysis of randomized controlled trials	1
Changes in the intestinal microbiota of patients with Parkinson’s disease and their clinical significance	1
Comparison of vancomycin area under the curve calculated based on Bayesian approach versus equation-based approach	1
Signal detection of botulinum toxin type A (BoNT/A) using the Korea Adverse Event Reporting System Database, 1999 – 2016	1
Monitoring of blood levels in patients administered CYP3A4 inhibitor during the maintenance phase of venetoclax administration	1
Clinical and research implications of uricase knockout and renal injury	1
Latent class analysis of patients’ background factors affecting the risk of specific adverse drug reactions to dipeptidyl peptidase 4 inhibitors	1
Pulmonary fibrosis insights and therapy targets from disease models and administration of the lipophilic diterpene, sodium tanshinone IIA sulfonate: Review and meta-analysis	1
Prescribing patterns in breast cancer survivors: A Korean National Health Insurance Service cohort study	1
Association between corticosteroid therapy and diagnosis of non-traumatic rotator cuff tear or rupture in patients followed in orthopedic practices in Germany	1
Analysis of neutropenia as a predictive factor of the efficacy of trifluridine-tipiracil treatment	1
Severe hypertriglyceridemia induced by S-1: Subsequent case series of four patients and further review of the literature	1
Early acute kidney injury after tacrolimus administration in heart transplant recipients receiving basiliximab induction therapy	1
Comparative efficacy and safety of dotinurad, febuxostat, and benzbromarone in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials	1
Platelet count and dose, but not comorbidities, predict severe neutropenia in cabazitaxel-treated prostate cancer patients: A retrospective observational study	1
Comparative bioavailability study with two sodium valproate tablet formulations administered under fasting conditions in healthy subjects	1
Porcine antilymphocyte globulin versus rabbit antithymocyte globulin for intensive immunosuppressive therapy of acquired aplastic anemia: A meta-analysis and systematic review	1
Impact of urinary albumin excretion on the onset of adverse reactions to vancomycin hydrochloride	1
Efficacy of antacids for cisplatin-induced gastrointestinal symptoms in the treatment of lung cancer	1
Predictors for non-attainment of meropenem target concentrations when treating infections in critically ill patients	1
Association between trough plasma voriconazole concentration and adverse drug reactions in elderly patients	1