OOIR: Observatory of International Research

Papers

(The median citation count of Matrix Biology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Fibroblasts: The arbiters of extracellular matrix remodeling	75
Targeting the renin-angiotensin-aldosterone system in fibrosis	73
Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes	64
Cardiac fibroblast activation during myocardial infarction wound healing	60
Extracellular matrix-derived peptides in tissue remodeling and fibrosis	54
Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development	51
TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression	46
Spatial-omics: Novel approaches to probe cell heterogeneity and extracellular matrix biology	45
Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers	43
Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis	40
Accumulation of versican facilitates wound healing: Implication of its initial ADAMTS-cleavage site	40
The elephant in the lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung development and regeneration	38
Basement membrane ligands initiate distinct signalling networks to direct cell shape	38
Decorin regulates cartilage pericellular matrix micromechanobiology	37
Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon	37
Tendon response to matrix unloading is determined by the patho-physiological niche	35
Regulators of cardiac fibroblast cell state	35
Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function	35
Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix	34
A novel ADAMTS17 variant that causes Weill-Marchesani syndrome 4 alters fibrillin-1 and collagen type I deposition in the extracellular matrix	33
Fibroblast heterogeneity and its impact on extracellular matrix and immune landscape remodeling in cancer	32
Fibronectin has multifunctional roles in posterior capsular opacification (PCO)	32
Role of collagen XII in skin homeostasis and repair	31
Role of autophagy in intervertebral disc and cartilage function: implications in health and disease	30
Multimerin-2 maintains vascular stability and permeability	29

Cancer associated fibroblast: Mediators of tumorigenesis	29
Computational model predicts paracrine and intracellular drivers of fibroblast phenotype after myocardial infarction	29
Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores	28
TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease	28
A novel mechanism in wound healing: Laminin 332 drives MMP9/14 activity by recruiting syndecan-1 and CD44	27
Autophagy, tissue repair, and fibrosis: a delicate balance	27
Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype	27
Cardiac fibroblast diversity in health and disease	27
T-cell regulation of fibroblasts and cardiac fibrosis	26
Connexin43 gap junction drives fascia mobilization and repair of deep skin wounds	26
Mechanisms of procollagen and HSP47 sorting during ER-to-Golgi trafficking	25
Periostin and matrix stiffness combine to regulate myofibroblast differentiation and fibronectin synthesis during palatal healing	24
Distinct extracellular–matrix remodeling events precede symptoms of inflammation	24
Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer	23
Schwann cells contribute to keloid formation	23
Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis	23
The C-type lectin CD93 controls endothelial cell migration via activation of the Rho family of small GTPases	23
H-Ras activation and fibroblast-induced TGF-β signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma	22
ECM-regulation of autophagy: The yin and the yang of autophagy during wound healing	21
Calponin 1 increases cancer-associated fibroblasts-mediated matrix stiffness to promote chemoresistance in gastric cancer	21
Significance of host heparanase in promoting tumor growth and metastasis	20
Heparanase promotes myeloma stemness and in vivo tumorigenesis	20
Biglycan: A regulator of hepatorenal inflammation and autophagy	20
Citrullination as a novel posttranslational modification of matrix metalloproteinases	19
Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis	19
Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers	19
Scavenger Receptor Cysteine-Rich domains of Lysyl Oxidase-Like2 regulate endothelial ECM and angiogenesis through non-catalytic scaffolding mechanisms	19
Atrial fibrillation and cardiac fibrosis: A review on the potential of extracellular matrix proteins as biomarkers	18
Targeting cellular stress in vitro improves osteoblast homeostasis, matrix collagen content and mineralization in two murine models of osteogenesis imperfecta	18
A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy	18
Reciprocal integrin/integrin antagonism through kindlin-2 and Rho GTPases regulates cell cohesion and collective migration	18
Causes and consequences of DNA damage-induced autophagy	17
Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome	17
PGC1α suppresses kidney cancer progression by inhibiting collagen-induced SNAIL expression	17
Glypican-6 stimulates intestinal elongation by simultaneously regulating Hedgehog and non-canonical Wnt signaling	16
A novel ocular function for decorin in the aqueous humor outflow	16
Asporin, an extracellular matrix protein, is a beneficial regulator of cardiac remodeling	16
Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension	16
Autophagy: Instructions from the extracellular matrix	16
The basement membrane in the cross-roads between the lung and kidney	16
Microfibrillar-associated protein 4 in health and disease	15
Multi-scale models of lung fibrosis	15
Dynamics of the lens basement membrane capsule and its interaction with connective tissue-like extracapsular matrix proteins	14
Organization of the laminin polymer node	14
Cartilage oligomeric matrix protein fine-tunes disturbed flow-induced endothelial activation and atherogenesis	14
The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism	14
The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors	13
Protein quality control by the proteasome and autophagy: A regulatory role of ubiquitin and liquid-liquid phase separation	13
Hedgehog signaling underlying tendon and enthesis development and pathology	13
Organelle-specific mechanisms of drug-induced autophagy-dependent cell death	13

Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy	13
Corneal fibroblast collagen type IV negative feedback modulation of TGF beta: A fibrosis modulating system likely active in other organs	13
Alternative splicing controls cell lineage-specific responses to endogenous innate immune triggers within the extracellular matrix	13
Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair	13
A collagen Vα1-derived fragment inhibits FGF-2 induced-angiogenesis by modulating endothelial cells plasticity through its heparin-binding site	12
Fibrillin-1 regulates white adipose tissue development, homeostasis, and function	12
Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate	12
Heparanase 2 (Hpa2) attenuates tumor growth by inducing Sox2 expression	12
Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia	11
Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis	11
Site-specific glycosylation of proteoglycans: A revisited frontier in proteoglycan research	11
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice	11
Heparanase 2 (Hpa2) attenuates the growth of pancreatic carcinoma	11
Latent TGFβ complexes are transglutaminase cross-linked to fibrillin to facilitate TGFβ activation	11
Chemotherapy treatment induces pro-invasive changes in liver ECM composition	11
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues	11
Autophagy in the mesh of collagen VI	11
Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts	10
Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid	10
Analysis of extracellular matrix network dynamics in cancer using the MatriNet database	10
Nitrosylation of tissue transglutaminase enhances fibroblast migration and regulates MMP activation	10
Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation	10
Mammary collagen is under reproductive control with implications for breast cancer	10
RIPK3-MLKL signaling activates mitochondrial CaMKII and drives intrarenal extracellular matrix production during CKD	10
Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology	10
Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish	10
Human intestinal myofibroblasts deposited collagen VI enhances adhesiveness for T cells – A novel mechanism for maintenance of intestinal inflammation	9
Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2	9
ADAM15 is required for optimal collagen cross-linking and scar formation following myocardial infarction	9
Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironment	9
Tenascin-C restricts reactive astrogliosis in the ischemic brain	9
Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging	9
Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma	9
Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland	8
PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis	8
A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage	8
Cysteine-rich domain of type III collagen N-propeptide inhibits fibroblast activation by attenuating TGFβ signaling	8
A common SNP risk variant MT1-MMP causative for Dupuytren's disease has a specific defect in collagenolytic activity	8
O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development	8
The alternative matrisome: Alternative splicing of ECM proteins in development, homeostasis and tumor progression	8
Activation of the ATX/LPA/LPARs axis induces a fibrotic response in skeletal muscle	8
Putting the brakes on autophagy: The role of heparan sulfate modified proteins in the balance of anabolic and catabolic pathways and intracellular quality control	8
Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function	7
When lipid homeostasis runs havoc: Lipotoxicity links lysosomal dysfunction to autophagy	7
Matrisome alterations in obesity – Adipose tissue transcriptome study on monozygotic weight-discordant twins	7
Mechanistic interrogation of mutation-independent disease modulators of RDEB identifies the small leucine-rich proteoglycan PRELP as a TGF-β antagonist and inhibitor of fibrosis	7
Induction of heparanase 2 (Hpa2) expression by stress is mediated by ATF3	7
EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin deposition	7
Molecular mechanisms mediating stiffening in the mechanically adaptable connective tissues of sea cucumbers	7
The synthesis and secretion of versican isoform V3 by mammalian cells: A role for N-linked glycosylation	7
Accumulation of versican and lack of versikine ameliorate acute colitis	7
Increased expression of the pathological O-glycosylated form of oncofetal fibronectin in the multidrug resistance phenotype of cancer cells	7
Echinatin maintains glutathione homeostasis in vascular smooth muscle cells to protect against matrix remodeling and arterial stiffening	7
Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo	7
Ameloblastin promotes polarization of ameloblast cell lines in a 3-D cell culture system	7
Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells	7
Mechanical loading is required for initiation of extracellular matrix deposition at the developing murine myotendinous junction	7
Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility	6
Systematic Analysis of Actively Transcribed Core Matrisome Genes Across Tissues and Cell Phenotypes	6
Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection	6
Ubiquitin conjugating enzymes in the regulation of the autophagy-dependent degradation pathway	6
Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro	6
EMILIN-1 deficiency promotes chronic inflammatory disease through TGFβ signaling alteration and impairment of the gC1q/α4β1 integrin interaction	6
Obesity impairs skeletal muscle repair through NID-1 mediated extracellular matrix remodeling by mesenchymal progenitors	6
The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc	6
Infiltrating CD8+ T cells and M2 macrophages are retained in tumor matrix tracks enriched in low tension fibronectin fibers	6
Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis	6
Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and disease	6