OOIR: Observatory of International Research

Papers

(The median citation count of Matrix Biology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes	70
Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon	47
Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function	45
Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis	44
Decorin regulates cartilage pericellular matrix micromechanobiology	43
Autophagy, tissue repair, and fibrosis: a delicate balance	40
Role of collagen XII in skin homeostasis and repair	37
Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix	37
TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease	37
Schwann cells contribute to keloid formation	35
Role of autophagy in intervertebral disc and cartilage function: implications in health and disease	34
Microfibrillar-associated protein 4 in health and disease	32
Connexin43 gap junction drives fascia mobilization and repair of deep skin wounds	29
Calponin 1 increases cancer-associated fibroblasts-mediated matrix stiffness to promote chemoresistance in gastric cancer	29
Periostin and matrix stiffness combine to regulate myofibroblast differentiation and fibronectin synthesis during palatal healing	28
The C-type lectin CD93 controls endothelial cell migration via activation of the Rho family of small GTPases	27
A novel mechanism in wound healing: Laminin 332 drives MMP9/14 activity by recruiting syndecan-1 and CD44	27
Distinct extracellular–matrix remodeling events precede symptoms of inflammation	26
Mechanisms of procollagen and HSP47 sorting during ER-to-Golgi trafficking	26
Causes and consequences of DNA damage-induced autophagy	26
Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer	25
Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis	24
Targeting cellular stress in vitro improves osteoblast homeostasis, matrix collagen content and mineralization in two murine models of osteogenesis imperfecta	23
Biglycan: A regulator of hepatorenal inflammation and autophagy	22
The basement membrane in the cross-roads between the lung and kidney	22

Significance of host heparanase in promoting tumor growth and metastasis	22
ECM-regulation of autophagy: The yin and the yang of autophagy during wound healing	22
Citrullination as a novel posttranslational modification of matrix metalloproteinases	21
Organization of the laminin polymer node	20
Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers	20
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues	20
Asporin, an extracellular matrix protein, is a beneficial regulator of cardiac remodeling	19
A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy	19
Autophagy: Instructions from the extracellular matrix	19
Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension	19
The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors	19
A novel ocular function for decorin in the aqueous humor outflow	19
Dynamics of the lens basement membrane capsule and its interaction with connective tissue-like extracapsular matrix proteins	18
Reciprocal integrin/integrin antagonism through kindlin-2 and Rho GTPases regulates cell cohesion and collective migration	18
Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair	18
Heparanase 2 (Hpa2) attenuates tumor growth by inducing Sox2 expression	18
Mammary collagen is under reproductive control with implications for breast cancer	18
Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis	17
Hedgehog signaling underlying tendon and enthesis development and pathology	17
Organelle-specific mechanisms of drug-induced autophagy-dependent cell death	16
The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism	16
Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma	16
Protein quality control by the proteasome and autophagy: A regulatory role of ubiquitin and liquid-liquid phase separation	16
Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy	16
Latent TGFβ complexes are transglutaminase cross-linked to fibrillin to facilitate TGFβ activation	16
Cartilage oligomeric matrix protein fine-tunes disturbed flow-induced endothelial activation and atherogenesis	16
Fibrillin-1 regulates white adipose tissue development, homeostasis, and function	16
Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology	15
Chemotherapy treatment induces pro-invasive changes in liver ECM composition	15
A collagen Vα1-derived fragment inhibits FGF-2 induced-angiogenesis by modulating endothelial cells plasticity through its heparin-binding site	15
Alternative splicing controls cell lineage-specific responses to endogenous innate immune triggers within the extracellular matrix	15
Corneal fibroblast collagen type IV negative feedback modulation of TGF beta: A fibrosis modulating system likely active in other organs	15
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice	14
Autophagy in the mesh of collagen VI	14
Cysteine-rich domain of type III collagen N-propeptide inhibits fibroblast activation by attenuating TGFβ signaling	14
Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish	14
Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate	14
Human intestinal myofibroblasts deposited collagen VI enhances adhesiveness for T cells – A novel mechanism for maintenance of intestinal inflammation	14
Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging	13
Site-specific glycosylation of proteoglycans: A revisited frontier in proteoglycan research	13
Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation	13
Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility	12
Tenascin-C restricts reactive astrogliosis in the ischemic brain	12
Heparanase 2 (Hpa2) attenuates the growth of pancreatic carcinoma	12
Echinatin maintains glutathione homeostasis in vascular smooth muscle cells to protect against matrix remodeling and arterial stiffening	12
Tumor-associated fibrosis impairs the response to immunotherapy	12
Analysis of extracellular matrix network dynamics in cancer using the MatriNet database	12
Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo	12
Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2	12
Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts	11

Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid	11
Nitrosylation of tissue transglutaminase enhances fibroblast migration and regulates MMP activation	11
RIPK3-MLKL signaling activates mitochondrial CaMKII and drives intrarenal extracellular matrix production during CKD	11
Putting the brakes on autophagy: The role of heparan sulfate modified proteins in the balance of anabolic and catabolic pathways and intracellular quality control	11
The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc	11
Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review	11
O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development	11
Mechanical loading is required for initiation of extracellular matrix deposition at the developing murine myotendinous junction	10
Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection	10
Activation of the ATX/LPA/LPARs axis induces a fibrotic response in skeletal muscle	10
Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironment	10
Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland	10
ADAM15 is required for optimal collagen cross-linking and scar formation following myocardial infarction	10
ADAMTS6 cleaves the large latent TGFβ complex and increases the mechanotension of cells to activate TGFβ	10
PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis	10
Elevated TGFβ signaling contributes to ocular anterior segment dysgenesis in Col4a1 mutant mice	9
Matrisome alterations in obesity – Adipose tissue transcriptome study on monozygotic weight-discordant twins	9
Collagen VI deposition mediates stromal T cell trapping through inhibition of T cell motility in the prostate tumor microenvironment	9
Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function	9
Targeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharides	9
A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage	9
Mechanistic interrogation of mutation-independent disease modulators of RDEB identifies the small leucine-rich proteoglycan PRELP as a TGF-β antagonist and inhibitor of fibrosis	9
Molecular mechanisms mediating stiffening in the mechanically adaptable connective tissues of sea cucumbers	9
Systematic Analysis of Actively Transcribed Core Matrisome Genes Across Tissues and Cell Phenotypes	9
Accumulation of versican and lack of versikine ameliorate acute colitis	9
Induction of heparanase 2 (Hpa2) expression by stress is mediated by ATF3	9
Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection	8
Autocrine IL-6 drives cell and extracellular matrix anisotropy in scar fibroblasts	8
When lipid homeostasis runs havoc: Lipotoxicity links lysosomal dysfunction to autophagy	8
ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation	8
EMILIN-1 deficiency promotes chronic inflammatory disease through TGFβ signaling alteration and impairment of the gC1q/α4β1 integrin interaction	8
Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma	8
Regulation of the collagen IV network by the basement membrane protein perlecan is crucial for squamous epithelial cell morphogenesis and organ architecture	8
Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis	8
Infiltrating CD8+ T cells and M2 macrophages are retained in tumor matrix tracks enriched in low tension fibronectin fibers	8
Substrate stiffness regulates the recurrent glioblastoma cell morphology and aggressiveness	8
CCBE1 promotes mitochondrial fusion by inhibiting the TGFβ-DRP1 axis to prevent the progression of hepatocellular carcinoma	8
Obesity impairs skeletal muscle repair through NID-1 mediated extracellular matrix remodeling by mesenchymal progenitors	8
Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and disease	8
EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin deposition	8
LTBP1 promotes fibrillin incorporation into the extracellular matrix	8
Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells	8
A common SNP risk variant MT1-MMP causative for Dupuytren's disease has a specific defect in collagenolytic activity	8
The gelatinases, matrix metalloproteinases 2 and 9, play individual roles in skeleton development	7
Positive feedback loops between fibroblasts and the mechanical environment contribute to dermal fibrosis	7
Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons	7
Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9	7
Matricellular proteins in atherosclerosis development	7
Increased expression of the pathological O-glycosylated form of oncofetal fibronectin in the multidrug resistance phenotype of cancer cells	7
Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction	7
Mutant MESD links cellular stress to type I collagen aggregation in osteogenesis imperfecta type XX	7
Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function	7
Modulating tenascin-C functions by targeting the MAtrix REgulating MOtif, “MAREMO”	7
Ubiquitin conjugating enzymes in the regulation of the autophagy-dependent degradation pathway	7
Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro	7
Ameloblastin promotes polarization of ameloblast cell lines in a 3-D cell culture system	7
Elevated TGFβ signaling contributes to cerebral small vessel disease in mouse models of Gould syndrome	7
The dynamic kidney matrisome - is the circadian clock in control?	7
TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids	7
Circulating hyaluronic acid signature in CAP and ARDS – the role of pneumolysin in hyaluronic acid shedding	7
Degradomics technologies in matrisome exploration	6
Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating WNT signaling	6
The extracellular matrix – immune microenvironment crosstalk in cancer therapy: Challenges and opportunities	6
Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis	6
Temporally and spatially regulated collagen XVIII isoforms are involved in ureteric tree development via the TSP1-like domain	6
Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing	6
Molecular cues for immune cells from small leucine-rich repeat proteoglycans in their extracellular matrix-associated and free forms	6
Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis	6