Phytomedicine

Article	Citations
Effects of Clausena lansium leaves volatile oil emulsion against Staphylococcus aureus in mice via autophagy modulation	270
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor	256
Baicalin attenuates pulmonary hypertension by targeting AMPK/CPT1A-mediated fatty acid metabolism	241
Exploring Dimethylsulfoniopropionate as a potential treatment for Alzheimer's disease: A study using the 3 × Tg-AD mouse model	235
Notoginsenoside R1 reduces acquired lymphedema and increases lymphangiogenesis by promoting VEGF-C expression via cAMP/PKA/CREB signaling	195
Guanxinning tablets plus aspirin versus aspirin monotherapy to reduce cardiovascular events after percutaneous coronary intervention: A cluster-randomized controlled trial (GAP trial)	194
The pathogenesis of hepatocellular carcinoma: ERK/ULK1/NCOA4-mediated inhibition of iron autophagy, and Epimedium extract targeted modulation of this pathway to treat hepatocellular carcinoma	171
Sanguinarine ameliorates DSS induced ulcerative colitis by inhibiting NLRP3 inflammasome activation and modulating intestinal microbiota in C57BL/6 mice	168
Pterostilbene mitigates scopolamine-induced cognitive impairment by modulating cholinergic pathway and reducing neuroinflammation	152
Uncovering the underlying mechanism of yuanhuacine against colorectal cancer by transcriptomics and experimental investigations	150
Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6	145
Wei-dong granules ameliorate functional dyspepsia via multi-targeted gut-brain axis modulation	145
Comparative effectiveness of glycyrrhizic acid preparations aimed at improving liver function of patients with chronic hepatitis B: A network meta-analysis of 53 randomized controlled trials	143
Modified Ganlu Xiaodu decoction attenuates airway barrier injury in Mycoplasma pneumoniae pneumonia by inhibiting ZBP1-mediated PANoptosis	135
Diacerein attenuates sepsis shock mortality through combined suppression of vascular inflammation, stiffness, and permeability	133
Naringenin exerts antiarrhythmic action in septic cardiomyopathy by downregulating the CaMKⅡ/Drp1/Bcl-2 pathway	128
Inhibition of influenza a virus infection by natural isoquinoline alkaloid neferine targeting virus nucleoprotein	126
Neuroprotective role of geniposide-loaded UMSC nanovesicles in depression via P2ry12 downregulation	125
Artemisia Argyi essential oil ameliorates acetaminophen-induced hepatotoxicity via CYP2E1 and γ-glutamyl cycle reprogramming	123
Multi-omics characterization of prognostic signature and novel molecular subtypes associated with anoikis and in vitro validation of CDKN2A in thyroid carcinoma	123
Hypoglycemic TCM formulas (Huangqi-Gegen drug pair) have the potential as an Alzheimer's disease	119
Lavender: phytochemistry, pharmacology, cross-disciplinary applications, and clinical efficacy	118
Astragaloside IV alleviates post-traumatic cytotoxic edema via inhibition of AQP4 expression and subcellular localization	117
Pedunculoside ameliorates metabolic dysfunction-associated steatotic liver disease by targeting HNRNPA1 and modulating PPARα signaling pathway to enhance Mitochondrial Fatty Acid β-Oxidation	106
Artesunate triggers ferroptosis in ovarian cancer via GP130-mediated IL-6/STAT3/OTUB1/SLC711 axis disruption	106

Gastrodin ameliorates DSS-induced ulcerative colitis via enhancing the abundance of Akkermansia muciniphila and modulating the metabolites	106
Effect of modified Jianpi Yangzheng on regulating content of PKM2 in gastric cancer cells-derived exosomes	105
Clinical efficacy of Jingyin granules, a Chinese patent medicine, in treating patients infected with coronavirus disease 2019	104
Dissecting the neuronal mechanisms of pinoresinol against methamphetamine addiction based on network and experimental pharmacology	101
Sanfeng Tongqiao Dripping Pills alleviate House Dust Mite-induced allergic rhinitis in mice by inhibiting Th2 differentiation and repairing the nasal epithelial barrier	100
Xijiao Dihuang decoction combined with Yinqiao powder promotes autophagy-dependent ROS decrease to inhibit ROS/NLRP3/pyroptosis regulation axis in influenza virus infection	99
Shenfu injection ameliorates coagulopathy in sepsis-associated liver injury via dual inhibition of endothelial cell pyroptosis	98
Huangqi Jianzhong decoction improves gastric intestinal metaplasia in rats by regulating the gut‒thyroid axis	97
Angelicin alleviates sepsis-associated encephalopathy via inhibition of IKK2 and the NF-κB pathway	95
Ginsenoside Rh2: A shining and potential natural product in the treatment of human nonmalignant and malignant diseases in the near future	95
Identification of Asari Radix et Rhizoma derived from three close Asarum species using the complete chloroplast genome	94
Targeting the virulence factor suilysin: a structure-guided discovery of chebulinic acid as a potent antivirulence agent	94
Rosmarinic acid potentiates and detoxifies tacrine in combination for Alzheimer's disease	92
Andrographolide induces ferroptosis in colorectal cancer via P53-mediated downregulation of the SLC7A11/GPX4 signaling pathway	92
Echinacoside inhibits tumor immune evasion by downregulating inducible PD-L1 and reshaping tumor immune landscape in breast and colorectal cancer	92
Okanin attenuates ovariectomy-induced bone loss in mice model through inhibition of IKKβ-mediated NF-κB p65 phosphorylation	92
Efficacy and safety of Kegan Liyan oral liquid for patients with acute pharyngitis: A randomized, double-blinded, placebo-controlled, multi-center trial	92
Astilbin alleviates hepatic fibrosis through PXR-PINK1/Parkin pathway: A new strategy by regulating hepatic stellate cells-macrophage crosstalk	91
Anti-tumor effects of novel alkannin derivatives with potent selectivity on comprehensive analysis	90
Effect of emodin on Streptococcus suis by targeting β-ketoacyl-acyl carrier protein synthase Ⅱ	88
Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporosis by inhibiting ferroptosis through the Nrf2/GPX4/SLC7A11 pathway	87
Bakuchiol mitigates colitis through GPR120 activation	87
Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties	85
Notoginsenoside Fc, a novel renoprotective agent, ameliorates glomerular endothelial cells pyroptosis and mitochondrial dysfunction in diabetic nephropathy through regulating HMGCS2 pathway	85
Madecassoside alleviates acute kidney injury by regulating JNK-mediated oxidative stress and programmed cell death	84
Vitamin K2 (MK7) alleviates arsenic-induced cardiac hypertrophy by suppressing the EGR3/BOK mitochondrial apoptosis pathway	84
Comparative analysis of lipid-lowering mechanisms in efficacy-divergent traditional Chinese medicines	83
Salidroside derivative SHPL-49 attenuates glutamate excitotoxicity in acute ischemic stroke via promoting NR2A-CAMKⅡα-Akt /CREB pathway	83
Phenethyl isothiocyanate ameliorates high-fat diet-induced obesity by antagonizing hypothalamic leptin resistance	81
Xin-yi-san contains potent human CYP1A2 inhibitors and its combined use with theophylline in treatment increases adverse risks in patients	81
Aristolone in Nardostachys jatamansi DC. induces mesenteric vasodilation and ameliorates hypertension via activation of the KATP channel and PDK1-Akt-eNOS pathway	80
Exploring the boost of steaming with wine on Ligustri Lucidi Fructus in treating postmenopausal osteoporosis based on superior “multi-component structure” and iron/bone metabolism coregulation	79
Biomarkers and potential mechanisms of Chinese medicine compound (Chuanhong Zhongfeng Capsule) in the treatment of acute cerebral infarction	79
SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway	78
Bazibushen attenuates fibroblast senescence in silica-induced pulmonary fibrosis via FOXO1/PINK1/Parkin Axis	77
Shengmai san-derived compound prescriptions: A review on chemical constituents, pharmacokinetic studies, quality control, and pharmacological properties	77
Zhilining Formula alleviates DSS-induced colitis through suppressing inflammation and gut barrier dysfunction via the AHR/NF-κBp65 axis	76
Integrative multi-omics unravels the amelioration effects of Zanthoxylum bungeanum Maxim. on non-alcoholic fatty liver disease	76
Integration of pharmacodynamics and metabolomics reveals the therapeutic effects of 6-acetylacteoside on ovariectomy-induced osteoporosis mice	76
Suo Quan Wan ameliorates bladder overactivity and regulates neurotransmission via regulating Myosin Va protein expression	76
A combination of Tropaeolum majus herb and Armoracia rusticana root for the treatment of acute bronchitis	76
Nobiletin targets SREBP1/ACLY to induce autophagy-dependent cell death of gastric cancer cells through PI3K/Akt/mTOR signaling pathway	74
Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k/akt pathway-mediated apoptosis, autophagy and ferroptosis	74
Kirenol alleviates cerebral ischemic injury by promoting synaptic plasticity via HDAC2-mediated BDNF expression	74
Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway	73
Qingjin Pingchuan formula attenuates pulmonary inflammation by reprogramming neutrophil SHP1-JAK2/SRC-STAT3 signaling	73
A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Tongmai Yangxin pill on ventricular remodeling in acute anterior STEMI patients after primary PCI	73
Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via NF-κB pathway inhibition	72
6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier	72
Nobiletin alleviates UV-induced skin photodamage through protein kinase B-dependent mitochondrial protection and suppression of mitogen-activated protein kinase signaling	72

Multi-omics analyses reveal that hesperidin ameliorates high-altitude pulmonary hypertension by restoring gut-lung axis homeostasis	71
Protective effect of a novel nonsteroidal organoselenium compound SLL-1-43 on ulcerative colitis through down-regulating NOX2 signaling pathway in vitro and in vivo	71
High-fat Diet-associated Digestive Cancers: Mechanisms, Natural Product-based Therapies, and Drug Development	71
Fuzhengjiedu formula exerts protective effect against LPS-induced acute lung injury via gut-lung axis	71
Ginsenoside Rg1 modulates PI3K/AKT pathway for enhanced osteogenesis via GPER	71
Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of Alzheimer's disease	71
Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy	71
Salvianolic acid B alleviates rheumatoid arthritis by inhibiting oxidative stress and pyroptosis through the Keap1-Nrf2/ROS/NLRP3 axis	70
Natural products as Nrf2 modulators for ferroptosis inhibition in renal disease therapy: Recent progress and future prospects	70
Targeting autophagy to discover the Piper wallichii petroleum ether fraction exhibiting antiaging and anti-Alzheimer's disease effects in Caenorhabditis elegans	69
Polyphenolic extracts from Diospyros kaki and Vitis vinifera by-products stimulate cytoprotective effects in bacteria-cell host interactions by mediation of transcription factor Nrf2	69
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis	69
Traditional Chinese medicine and mitophagy: A novel approach for cardiovascular disease management	69
Oleandrin-mediated suppression of MELK induces apoptosis, autophagy, and ferroptosis in human non-small cell lung cancer cells	69
Gut microbiome and tissue metabolomics reveal the compatibility effects of Xiaoyaosan on depression based on “gut-liver-kidney” axis	69
Verbascoside: A neuroprotective phenylethanoid glycosides with anti-depressive properties	69
Astragaloside IV remodels gastric inflammation-cancer transformation by modulating the CXCL5-CXCR2 axis-mediated epithelial-mesenchymal transition	68
Siwu decoction suppress myeloid-derived suppressor cells through tumour cells necroptosis to inhibit hepatocellular carcinoma	68
Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats	68
Efficacy and safety of Qianlieshutong Capsules in the treatment for Type Ⅲ prostatitis: a post-marketing, multicenter, randomized, double-blind, single-dummy, active-controlled, parallel-group clinica	68
Huaier-induced suppression of cancer-associated fibroblasts confers immunotherapeutic sensitivity in triple-negative breast cancer	67
Phycocyanin as a nature-inspired antidiabetic agent: A systematic review	67
Vialinin A alleviates oxidative stress and neuronal injuries after ischaemic stroke by accelerating Keap1 degradation through inhibiting USP4-mediated deubiquitination	67
Protopanaxatriol activates EGFR and HER2 to strengthen the molecules of skin protection in human keratinocytes	67
Study on the mechanism of Trichosanthes kirilowii Maxim. against COPD based on serum chemical composition analysis, network pharmacology, and experimental study	67
Dihydromyricetin regulates the miR-155-5p/SIRT1/VDAC1 pathway to promote liver regeneration and improve alcohol-induced liver injury	67
Study on the anti-liver cirrhosis of Fuzheng Huayu tablet : Targeting macrophage PPARα axis-fatty acid metabolic	66
Celastrol induces DNA damage and cell death in BCR-ABL T315I-mutant CML by targeting YY1 and HMCES	65
Formononetin improves cardiac function and depressive behaviours in myocardial infarction with depression by targeting GSK-3β to regulate macrophage/microglial polarization	65
Ethyl acetate extract of Antenoron Filiforme inhibits the proliferation of triple negative breast cancer cells via suppressing Skp2/p21 signaling axis	65
Unveiling the metabolites underlying the skin anti-ageing properties of Cytinus hypocistis (L.) L. through a biochemometric approach	65
Dendrobium huoshanense flavone attenuates radiation enteritis by enhancing gut immunity to inhibit inflammation and fibrosis	64
Mechanisms of traditional Chinese medicine in the treatment and prevention of gastric cancer	64
Shenling Kaixin granules attenuate depression via multi-target mechanisms: evidence from CSDS model and cellular studies	63
Didymin halts knee osteoarthritis progression by targeting the GSK3B/5-LOX/11-HETE pathway to suppress chondrocyte ferroptosis	63
Astragalus polysaccharides attenuate chemotherapy-induced immune injury by modulating gut microbiota and polyunsaturated fatty acid metabolism	63
Cynaroside attenuates uropathogenic Escherichia coli adhesion and invasion by suppressing bacterial virulence and down-modulating urothelial Caveolin-1 signaling	63
Caffeine enhances chemosensitivity to irinotecan in the treatment of colorectal cancer	62
Congming decoction alleviates Alzheimer’s Disease induced by Aβ25-35 in rats via the microbiota-metabolism-inflammation axis, demonstrating its formulation advantages	62
Xiao-Er-An-Shen Granule inhibits dopamine production to ameliorate Tourette syndrome in mice	61
Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway	61
Mechanisms for the biological activity of Gastrodia elata Blume and its constituents: A comprehensive review on sedative-hypnotic, and antidepressant properties	61
Xinjia Dayuan San for MDR-GN pneumonia: A randomized controlled trial	61
Hong Guo Ginseng Guo (HGGG) protects against kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome and regulating intestinal flora	61
Transcriptome profiling Revealed the potential mechanisms of Shen Lin Bai Zhu San n-butanol extract on DSS induced Colitis in Mice and LC-MS analysis	61
Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study	61
Efficacy and safety of YOXINTINE for depression: A double-blinded, randomized, placebo-controlled, phase 2 clinical trial	61
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway	61
Modified Xiaoyaosan rescues depression-like behavior via remodeling gut microbiota and leucine metabolism	61
Baicalin and ginsenoside Rb1 suppress the activation of cardiac fibroblasts via regulating the GRK2/AT1R/MasR network	60
Novel strategies for identification and prevention of idiosyncratic liver injury caused by TCM compatibility: Exemplification by Epimedii Folium and Psoraleae Fructus	60
Anacardic acid mitigates post‑MI cardiac fibrosis via suppressing p38/JNK–GATA3 pathway and H3K9ac‑dependent epigenetic regulation	60
Unraveling the role of Globularia species in modern medicine based on evidence from photochemistry, traditional uses and biological activities	60
New insights into phytochemicals via protein glycosylation focused on aging and diabetes	60
Exploring the neuroprotective effect and potential mechanism of Shenrong Guben Huanshao Pill based on multi-omics analysis	60
Targeting astrocytic Nrf2 by Trilobatin alleviates lipopolysaccharide-induced depressive-like behaviors and cognitive impairment in mice: Mechanistic insights into gut microbiota and metabolites modul	59
Fucoidan alleviates renal fibrosis in mice via Akkermansia muciniphila-mediated suppression of NEU1-TLR4-NFκB signaling axis	59
Zedoarondiol regulates steatosis and inflammation in alcoholic liver injury via PTP1B-target mechanisms	59
Kavain for health promotion and disease mitigation: Pharmacological promise and therapeutic perspectives	59
Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway	58
Targeting GATA6 with pedunculoside inhibits fetal gene expression to attenuate pathological cardiac hypertrophy	58
Parthenolide ameliorates inflammation in sepsis via covalently targeting Trim33 and inhibiting NF-κB pathway	58
Lanatoside C inhibits herpes simplex virus 1 replication by regulating NRF2 distribution within cells	58
Rapid antiepileptic activity identification of isopimpinellin using a multi-model of epilepsy based on behavior-biomarker-BBB screening pipeline	58
Gut microbiota-dependent modulation of pre-metastatic niches by Jianpi Yangzheng decoction in the prevention of lung metastasis of gastric cancer	58
Carpaine alleviates tendinopathy in mice by promoting the ubiquitin-proteasomal degradation of p65 via targeting the E3 ubiquitin ligase LRSAM1	58
Corrigendum to “Qiji Shujiang granules alleviates dopaminergic neuronal injury of parkinson's disease by inhibiting NLRP3/Caspase-1 pathway mediated pyroptosis” [Phytomedicine, 120, 2023, 155019]	57
Xingnao jianshen prescription reduces mitochondrial cristae breakage by protecting GPX1 from oxidation against cerebral ischemia-reperfusion injury	57
Ramulus Mori (Sangzhi) alkaloids enhance pancreatic β-Cell maturation and function by targeting the CD81/endoplasmic reticulum stress pathway	57
Huoxin pill prevents excessive inflammation and cardiac dysfunction following myocardial infarction by inhibiting adverse Wnt/β‑catenin signaling activation	57
Deciphering the therapeutic potential of SheXiangXinTongNing: Interplay between gut microbiota and brain metabolomics in a CUMS mice model, with a focus on tryptophan metabolism	56
Semen Cuscutae-Fructus Lycii attenuates tripterygium glycosides-induced spermatogenesis dysfunction by inhibiting oxidative stress-mediated ferroptosis via the Nrf2/HO-1 pathway	56
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin signaling to promote mitophagy and attenuate inflammation in chondrocytes	56
Lancao decoction alleviates cognitive dysfunction: A new therapeutic drug and its therapeutic mechanism	56
The extracts of Ardisia elliptica fruit attenuate inflammation in LPS-activated BV2 microglia via JNK, ERK1/2, p38, and NF-κB signaling inhibition	56
Isoliquiritigenin alleviates abnormal sarcomere contraction and inflammation in myofascial trigger points via the IL‐17RA/Act1/p38 pathway in rats	55
Chlorella pyrenoidosa-derived extracellular vesicles ameliorate ulcerative colitis through microbiota-mediated AKT/mTOR/ferroptosis pathway	55
Glycyrrhetinic acid orchestrates ERS-pyroptosis crosstalk to elicit immunogenic cell death in hepatocellular carcinoma	55
Kaempferol induces programmed cell death in Naegleria fowleri	55
Network pharmacology screening, in vitro and in vivo evaluation of antianxiety and antidepressant drug-food analogue	55

Wumei Wan alleviates intestinal fibrosis via the microbiota–metabolite–YAP–mechanotransduction axis	55
Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins—A new model for evaluating the content of prominent components of Chinese herbs	55
Kaempferol alleviates schizophrenia-like social and cognitive deficits through cholinergic modulation	55
RNA-binding domain 2 of nucleolin is important for the autophagy induction of curcumol in nasopharyngeal carcinoma cells	54
Tumor-derived S100A14 targeted astrocytes via TLR4 to Recruit myeloid-derived suppressor cells promoting brain metastasis and Curdione reversal effect	54
Celastrol induces ferroptosis in ccRCC through TEF-Driven ACOX2 upregulation and metabolic reprogramming	54
Corynoline inhibits esophageal squamous cell carcinoma growth via targeting Pim-3	54
Linarin protects against asthma-induced airway epithelial ferroptosis and inflammation via ALDH2 regulation	54
Berberine facilitates alveolar bone regeneration via Ptgs2-mediated dual regulation of osteoblast differentiation and fibroblast inhibition	54
Single-nucleus analysis reveals Dengzhan Shengmai capsule prevents cardiac fibrosis after myocardial infarction in rat by targeting Ltbp2+ fibroblast subset	54
Polydatin mitigates thrombosis by inhibiting PHD2-induced proline hydroxylation on collagen, reducing platelet adhesion	54
Chinese herbal medicine alleviates the pathogenesis of polycystic ovary syndrome by improving oxidative stress and glucose metabolism via mitochondrial Sirtuin 3 signaling	54
Oral rhein attenuate nonalcoholic steatohepatitis in mice through the modulation of gut microbiota and Th17 cell differentiation	53
Characterizing the specific mechanism of series processed Coptidis Rhizoma by multi-organ metabolomics combined with network pharmacology and molecular docking	53
Preventive mechanisms of Chinese Tibetan medicine Triphala against nonalcoholic fatty liver disease	53
Rutin ameliorates HCD-induced cholesterol metabolism disorder in zebrafish larvae revealed by transcriptome and metabolome analysis	53
Anti-tumor effects of Cinnamomum camphora essential oil in breast cancer via NOX4 modulation by (+)-2-bornanone	53
Intestinal 8 gingerol attenuates TBI-induced neuroinflammation by inhibiting microglia NLRP3 inflammasome activation in a PINK1/Parkin-dependent manner	53
Beneficial effects of Dendrobium officinale National Herbal Drink on metabolic immune crosstalk via regulate SCFAs-Th17/Treg	52
Exploring the possible mechanism(s) underlying the nephroprotective effect of Zhenwu Decoction in diabetic kidney disease: An integrated analysis	52
Fraxetin reduces endometriotic lesions through activation of ER stress, induction of mitochondria-mediated apoptosis, and generation of ROS	52
A Rhodiola-derived acidic glycopeptide maintains sleep homeostasis by regulating brain lipid metabolism in Drosophila	52
Xiaochaihutang ameliorates depression-like behaviors induced via chronic social defeat stress by regulating exon-specific Bdnf transcription through H3K18 acetylation in the hippocampus of mice	52
Wendan Decoction exerts therapeutic effects on insomnia by regulating gut microbiota and tryptophan metabolism	52
Tanshinone IIA positively regulates the Keap1-Nrf2 system to alleviate pulmonary fibrosis via the sestrin2-sqstm1 signaling axis-mediated autophagy	52
Oligomeric proanthocyanidin attenuates asthma severity and airway remodeling by modulating epithelial-smooth muscle cell interactions	52
Ellagic acid inhibits CDK12 to increase osteoblast differentiation and alleviate osteoporosis in hindlimb-unloaded and ovariectomized mice	52
Unveiling the therapeutic potential of Taxifolin in Cancer: From molecular mechanisms to immune modulation and synergistic combinations	52
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice	52
Phenotypic screening identified polydatin alleviating cartilage degeneration by modulating SIRT3-dependent mitochondrial dysfunction	52
ESL attenuates BLM-induced IPF in mice: Dual mediation of the TLR4/NF-κB and TGF-β1/PI3K/Akt/FOXO3a pathways	52
Dioscin suppresses epithelial-mesenchymal transition in gastric cancer by upregulating Cx43 to inhibit the VEGFA/PI3K/Akt/mTOR pathway	52
Gut microbiome and glial cell dialog: Role of TCM in the treatment of depression	52
YiQiChuTan formula (YQCTF) inhibit the progression of non-small cell lung cancer via down-regulating EGFR/ITGB2 signaling: Triangulated evidence from network pharmacology, proteomic profiling, and exp	52
Jinkui Shenqi pills ameliorate diabetes by regulating hypothalamic insulin resistance and POMC/AgRP expression and activity	51
Indole-3-carbinol inhibits PD-L1-mediated immune evasion in hepatocellular carcinoma via suppressing NF-κB p105 Ubiquitination	51
Taraxerol induces ferroptosis in breast cancer by targeting Nrf2 transcriptional activity to promote MIB2-mediated GPX4 ubiquitination	51
Siweixizangmaoru decoction attenuates collagen-induced arthritis via gut microbiota-dependent SCFA restoration and immunomodulation	51
Linderae Radix extract attenuates ulcerative colitis by inhibiting the JAK/STAT signaling pathway	51
Multi-level intervention of Tangluoning on mitochondrial thioredoxin deficiency in Schwann cells ameliorates diabetic peripheral neuropathy	51
Targeting p65 to inhibit Cas3 transcription by Onjisaponin B for radiation damage therapy in p65+/- mice	51
Morus alba L. (Sangzhi) alkaloids reduce polycystic ovary syndrome by improving hypothalamic-pituitary-ovarian axis function	51
Scutellarin-eluting stents attenuate coronary restenosis by inhibiting the abnormal proliferation and migration of vascular smooth muscle cells through suppression of NF-κB signaling	51
Sanmiao pill ameliorates rheumatoid arthritis via PPARγ-mediated lipid accumulation in macrophage: A multi-omics and experimental validation	51
Levo-tetrahydropalmatine ameliorates neuropathic pain by inhibiting the activation of the Clec7a-MAPK/NF-κB-NLRP3 inflammasome axis	51
Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review	51
Saponins from Dioscorea nipponinca Makino rehabilitate UVB-induced skin photoaging by inhibiting oxidative stress and apoptosis via targeting STAT3	51
Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs	50
The purified extract of Cremastrae pseudobulbus pleiones pseudobulbus (EPC) induces mitochondrial apoptosis in hepatocellular carcinoma cells through inhibiting a key oncogenic signaling pathway	50
Sweroside attenuates heart failure with preserved ejection fraction via targeting PCSK9-CD36 interaction to reduce cardiac-hepatic lipotoxicity	50
Single-cell profiling uncovers kaempferol-mediated immunoregulation in the protection against experimental autoimmune hepatitis	50
Eupalinolide B alleviates ulcerative colitis by targeting HMGB1 through modulation of the HMGB1/TLR4/MyD88/NF-κB signaling pathway	50
Advances in antitumor activity and mechanism of natural steroidal saponins: A review of advances, challenges, and future prospects	49
Bushen Huoxue Yiqi formula alleviates cardiac fibrosis in ischemic heart failure through SIRT1/Notch1 pathway-mediated EndMT	49
Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling	49
Ginger-processed Magnoliae Officinalis Cortex ameliorates ovalbumin-induced asthma by alleviating inflammation via the gut-lung axis	49
Celastrol ameliorates metabolic dysfunction associated steatohepatitis by regulating the CYP7B1-mediated alternative bile acid synthetic pathway	49
Tubson-2 decoction ameliorates rheumatoid arthritis complicated with osteoporosis in CIA rats involving isochlorogenic acid A regulating IL-17/MAPK pathway	49
Electrochemical-based quantitative fingerprint evaluation strategy combined with multi-markers assay by monolinear method for quality control of herbal medicine	49
Comparative analysis the chloroplast genomes of Celastrus (Celastraceae) species: Provide insights into molecular evolution, species identification and phylogenetic relationships	49
Exploring the antimicrobial activity of rare ginsenosides and the progress of their related pharmacological effects	49
Silymarin targets the FXR protein through microbial metabolite 7-keto-deoxycholic acid to treat MASLD in obese mice	49
Tongqiao Huoxue Decoction inhibits ferroptosis by facilitating ACSL4 ubiquitination degradation for neuroprotection against cerebral ischemia-reperfusion injury	49
XIAOPI formula inhibits chemoresistance and metastasis of triple-negative breast cancer by suppressing extracellular vesicle/CXCL1-induced TAM/PD-L1 signaling	49
Apigenin enhances Nrf2-induced chaperone-mediated autophagy and mitigates α-synuclein pathology: Implications for Parkinson's disease therapy	49
Berberine alleviates ulcerative colitis by inhibiting inflammation through targeting IRGM1	49
Anti-inflammatory effect of Danhong injection through inhibition of GSDMD-mediated pyroptosis	49
Draconis Sanguis (DS) from the fruit of Daemonorops draco Bl. ameliorates cardiac function through optimizing myocardial energy metabolism by promoting angiogenesis in ischemic heart failure	48
Hickory nut polyphenols enhance oxidative stress resilience and improve the longevity of Caenorhabditis elegans through modulating DAF-16/DAF-2 insulin/IGF-1 signaling	48
Guizhi-Fuling Wan suppresses carcinoma-associated mesenchymal stem cells-induced ovarian cancer progression via STAT3 inhibition	48
β-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function	48
Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways	48
Peanut (Arachis hypogaea L.) seeds and by-products in metabolic syndrome and cardiovascular disorders: A systematic review of clinical studies	47
Integrated network pharmacology and UHPLC–Q–TOF LC–MS/MS phytochemical profiling demonstrate tilianin-mediated restoration of PDE10A/cAMP/PKA/CREB signaling in an MK-801-induced schizophrenia-like mod	47
Chrysophanol exerts neuroprotection against cerebral ischemia- reperfusion injury by regulating IκBα-stabilized MLKL via ZNF460-TRAF6 axis	47
QiShenYiQi pill inhibits atherosclerosis by promoting TTC39B-LXR mediated reverse cholesterol transport in liver	47
Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway	47
Handelin inhibits osteoclastogenesis and bone loss by targeting lipocalin-2 and restoring autophagy to suppress NF-κB signaling	47
Cardamonin intervenes in myocardial hypertrophy progression by regulating Usp18	47
Qing Hua Yu Du formula ameliorates alcoholic hepatic fibrosis by regulating MAPK/TLR4-MyD88 inflammatory pathways, restoring hepatic metabolism and modulating gut microbiota	47
Licochalcone B alleviates atherosclerosis by inhibiting endothelial inflammation via targeting the KEAP1/NRF2/NF-κB signalling pathway	47
Five-layer-funnel filtering mode discovers effective components of Chinese medicine formulas: Zhishi-Xiebai-Guizhi decoction as a case study	47
Chaihu Shugan San mitigates esophageal injury via AMPK-FUNDC1 mitochondrial homeostasis: Multi-omics insights	47
Tetrastigma hemsleyanum polysaccharides alleviate inflammatory bowel disease via the gut microbiota–SCFA–GPR43 signaling axis	47
Preclinical investigation and clinical trials of Red ginseng as an immunomodulator: a narrative review from 2015 to 2025	47
Restoring gut microbiota homeostasis to ameliorate colitis via Huangqin decoction	46
Clinical outcomes and safety of Chinese herbal medicine in the treatment of hyperuricemia: A retrospective real-world study	46
High-throughput screened kaempferitrin potentiates trastuzumab efficacy in HER2-positive gastric cancer by targeting Cyclooxygenase-2 to inhibit ERK signaling	46
Acteoside targeting glutamine synthetase ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis	46
Ziziphora clinopodioides Flavonoids improve ischemic stroke by targeting FUNDC1-mediated mitophagy to reduce ferroptosis	46
Paeoniflorin alleviates anxiety-like behaviors in sleep-deprived male mice by suppressing inflammation of the paraventricular nucleus of the hypothalamus	46
Resveratrol combats Salmonella infection via liberating vacuole-enclosed bacteria for enhanced autophagic clearance and blocking HMGA2-mediated G2/M arrest	46
Mechanistic insights into the anti-oxidative and anti-inflammatory functions of covalent-reactive cinnamyl compounds within Cinnamomum cassia	46
Efficacy and safety of Shen-Qi Paste, a Traditional Chinese Medicine, in dialysis patients with sarcopenia: A randomized, double-blind, placebo-controlled trial	46
Urolithin A promotes the degradation of TMSB10 to deformation F-actin in non-small-cell lung cancer	46