OOIR: Observatory of International Research

Papers

(The H4-Index of Phytomedicine is 72. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Effects of Clausena lansium leaves volatile oil emulsion against Staphylococcus aureus in mice via autophagy modulation	270
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor	256
Baicalin attenuates pulmonary hypertension by targeting AMPK/CPT1A-mediated fatty acid metabolism	241
Exploring Dimethylsulfoniopropionate as a potential treatment for Alzheimer's disease: A study using the 3 × Tg-AD mouse model	235
Notoginsenoside R1 reduces acquired lymphedema and increases lymphangiogenesis by promoting VEGF-C expression via cAMP/PKA/CREB signaling	195
Guanxinning tablets plus aspirin versus aspirin monotherapy to reduce cardiovascular events after percutaneous coronary intervention: A cluster-randomized controlled trial (GAP trial)	194
The pathogenesis of hepatocellular carcinoma: ERK/ULK1/NCOA4-mediated inhibition of iron autophagy, and Epimedium extract targeted modulation of this pathway to treat hepatocellular carcinoma	171
Sanguinarine ameliorates DSS induced ulcerative colitis by inhibiting NLRP3 inflammasome activation and modulating intestinal microbiota in C57BL/6 mice	168
Pterostilbene mitigates scopolamine-induced cognitive impairment by modulating cholinergic pathway and reducing neuroinflammation	152
Uncovering the underlying mechanism of yuanhuacine against colorectal cancer by transcriptomics and experimental investigations	150
Wei-dong granules ameliorate functional dyspepsia via multi-targeted gut-brain axis modulation	145
Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6	145
Comparative effectiveness of glycyrrhizic acid preparations aimed at improving liver function of patients with chronic hepatitis B: A network meta-analysis of 53 randomized controlled trials	143
Modified Ganlu Xiaodu decoction attenuates airway barrier injury in Mycoplasma pneumoniae pneumonia by inhibiting ZBP1-mediated PANoptosis	135
Diacerein attenuates sepsis shock mortality through combined suppression of vascular inflammation, stiffness, and permeability	133
Naringenin exerts antiarrhythmic action in septic cardiomyopathy by downregulating the CaMKⅡ/Drp1/Bcl-2 pathway	128
Inhibition of influenza a virus infection by natural isoquinoline alkaloid neferine targeting virus nucleoprotein	126
Neuroprotective role of geniposide-loaded UMSC nanovesicles in depression via P2ry12 downregulation	125
Multi-omics characterization of prognostic signature and novel molecular subtypes associated with anoikis and in vitro validation of CDKN2A in thyroid carcinoma	123
Artemisia Argyi essential oil ameliorates acetaminophen-induced hepatotoxicity via CYP2E1 and γ-glutamyl cycle reprogramming	123
Hypoglycemic TCM formulas (Huangqi-Gegen drug pair) have the potential as an Alzheimer's disease	119
Lavender: phytochemistry, pharmacology, cross-disciplinary applications, and clinical efficacy	118
Astragaloside IV alleviates post-traumatic cytotoxic edema via inhibition of AQP4 expression and subcellular localization	117
Artesunate triggers ferroptosis in ovarian cancer via GP130-mediated IL-6/STAT3/OTUB1/SLC711 axis disruption	106
Gastrodin ameliorates DSS-induced ulcerative colitis via enhancing the abundance of Akkermansia muciniphila and modulating the metabolites	106

Pedunculoside ameliorates metabolic dysfunction-associated steatotic liver disease by targeting HNRNPA1 and modulating PPARα signaling pathway to enhance Mitochondrial Fatty Acid β-Oxidation	106
Effect of modified Jianpi Yangzheng on regulating content of PKM2 in gastric cancer cells-derived exosomes	105
Clinical efficacy of Jingyin granules, a Chinese patent medicine, in treating patients infected with coronavirus disease 2019	104
Dissecting the neuronal mechanisms of pinoresinol against methamphetamine addiction based on network and experimental pharmacology	101
Sanfeng Tongqiao Dripping Pills alleviate House Dust Mite-induced allergic rhinitis in mice by inhibiting Th2 differentiation and repairing the nasal epithelial barrier	100
Xijiao Dihuang decoction combined with Yinqiao powder promotes autophagy-dependent ROS decrease to inhibit ROS/NLRP3/pyroptosis regulation axis in influenza virus infection	99
Shenfu injection ameliorates coagulopathy in sepsis-associated liver injury via dual inhibition of endothelial cell pyroptosis	98
Huangqi Jianzhong decoction improves gastric intestinal metaplasia in rats by regulating the gut‒thyroid axis	97
Ginsenoside Rh2: A shining and potential natural product in the treatment of human nonmalignant and malignant diseases in the near future	95
Angelicin alleviates sepsis-associated encephalopathy via inhibition of IKK2 and the NF-κB pathway	95
Identification of Asari Radix et Rhizoma derived from three close Asarum species using the complete chloroplast genome	94
Targeting the virulence factor suilysin: a structure-guided discovery of chebulinic acid as a potent antivirulence agent	94
Echinacoside inhibits tumor immune evasion by downregulating inducible PD-L1 and reshaping tumor immune landscape in breast and colorectal cancer	92
Okanin attenuates ovariectomy-induced bone loss in mice model through inhibition of IKKβ-mediated NF-κB p65 phosphorylation	92
Efficacy and safety of Kegan Liyan oral liquid for patients with acute pharyngitis: A randomized, double-blinded, placebo-controlled, multi-center trial	92
Rosmarinic acid potentiates and detoxifies tacrine in combination for Alzheimer's disease	92
Andrographolide induces ferroptosis in colorectal cancer via P53-mediated downregulation of the SLC7A11/GPX4 signaling pathway	92
Astilbin alleviates hepatic fibrosis through PXR-PINK1/Parkin pathway: A new strategy by regulating hepatic stellate cells-macrophage crosstalk	91
Anti-tumor effects of novel alkannin derivatives with potent selectivity on comprehensive analysis	90
Effect of emodin on Streptococcus suis by targeting β-ketoacyl-acyl carrier protein synthase Ⅱ	88
Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporosis by inhibiting ferroptosis through the Nrf2/GPX4/SLC7A11 pathway	87
Bakuchiol mitigates colitis through GPR120 activation	87
Notoginsenoside Fc, a novel renoprotective agent, ameliorates glomerular endothelial cells pyroptosis and mitochondrial dysfunction in diabetic nephropathy through regulating HMGCS2 pathway	85
Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties	85
Vitamin K2 (MK7) alleviates arsenic-induced cardiac hypertrophy by suppressing the EGR3/BOK mitochondrial apoptosis pathway	84
Madecassoside alleviates acute kidney injury by regulating JNK-mediated oxidative stress and programmed cell death	84
Comparative analysis of lipid-lowering mechanisms in efficacy-divergent traditional Chinese medicines	83
Salidroside derivative SHPL-49 attenuates glutamate excitotoxicity in acute ischemic stroke via promoting NR2A-CAMKⅡα-Akt /CREB pathway	83
Xin-yi-san contains potent human CYP1A2 inhibitors and its combined use with theophylline in treatment increases adverse risks in patients	81
Phenethyl isothiocyanate ameliorates high-fat diet-induced obesity by antagonizing hypothalamic leptin resistance	81
Aristolone in Nardostachys jatamansi DC. induces mesenteric vasodilation and ameliorates hypertension via activation of the KATP channel and PDK1-Akt-eNOS pathway	80
Biomarkers and potential mechanisms of Chinese medicine compound (Chuanhong Zhongfeng Capsule) in the treatment of acute cerebral infarction	79
Exploring the boost of steaming with wine on Ligustri Lucidi Fructus in treating postmenopausal osteoporosis based on superior “multi-component structure” and iron/bone metabolism coregulation	79
SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway	78
Shengmai san-derived compound prescriptions: A review on chemical constituents, pharmacokinetic studies, quality control, and pharmacological properties	77
Bazibushen attenuates fibroblast senescence in silica-induced pulmonary fibrosis via FOXO1/PINK1/Parkin Axis	77
Integrative multi-omics unravels the amelioration effects of Zanthoxylum bungeanum Maxim. on non-alcoholic fatty liver disease	76
Integration of pharmacodynamics and metabolomics reveals the therapeutic effects of 6-acetylacteoside on ovariectomy-induced osteoporosis mice	76
Suo Quan Wan ameliorates bladder overactivity and regulates neurotransmission via regulating Myosin Va protein expression	76
A combination of Tropaeolum majus herb and Armoracia rusticana root for the treatment of acute bronchitis	76
Zhilining Formula alleviates DSS-induced colitis through suppressing inflammation and gut barrier dysfunction via the AHR/NF-κBp65 axis	76
Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k/akt pathway-mediated apoptosis, autophagy and ferroptosis	74
Kirenol alleviates cerebral ischemic injury by promoting synaptic plasticity via HDAC2-mediated BDNF expression	74
Nobiletin targets SREBP1/ACLY to induce autophagy-dependent cell death of gastric cancer cells through PI3K/Akt/mTOR signaling pathway	74
Qingjin Pingchuan formula attenuates pulmonary inflammation by reprogramming neutrophil SHP1-JAK2/SRC-STAT3 signaling	73
A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Tongmai Yangxin pill on ventricular remodeling in acute anterior STEMI patients after primary PCI	73
Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway	73
6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier	72
Nobiletin alleviates UV-induced skin photodamage through protein kinase B-dependent mitochondrial protection and suppression of mitogen-activated protein kinase signaling	72
Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via NF-κB pathway inhibition	72