OOIR: Observatory of International Research

Papers

(The TQCC of Amino Acids is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Multiple sclerosis and myelin basic protein: insights into protein disorder and disease	66
Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease	62
Use of alternative protein sources for fishmeal replacement in the diet of largemouth bass (Micropterus salmoides). Part I: effects of poultry by-product meal and soybean meal on growth, feed utilizat	52
Proline metabolism and redox; maintaining a balance in health and disease	50
The serum amino acid profile in COVID-19	49
The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review	45
Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function	45
Hydroxyproline in animal metabolism, nutrition, and cell signaling	42
Proline metabolism in cancer	40
Hunting the main protease of SARS-CoV-2 by plitidepsin: Molecular docking and temperature-dependent molecular dynamics simulations	36
Amino acid metabolism as a therapeutic target in cancer: a review	35
Proline metabolism and transport in retinal health and disease	34
The role of posttranslational modification in moonlighting glyceraldehyde-3-phosphate dehydrogenase structure and function	33
Glycine regulates mucosal immunity and the intestinal microbial composition in weaned piglets	33
Protein carbonylation in food and nutrition: a concise update	32
Proteomic comparison of different synaptosome preparation procedures	32
Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization	29
Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target	28
Methionine sulfoxide and the methionine sulfoxide reductase system as modulators of signal transduction pathways: a review	28
Lyophilization and homogenization of biological samples improves reproducibility and reduces standard deviation in molecular biology techniques	27
Use of alternative protein sources for fishmeal replacement in the diet of largemouth bass (Micropterus salmoides). Part II: effects of supplementation with methionine or taurine on growth, feed utili	26
Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment	24
PYCR, a key enzyme in proline metabolism, functions in tumorigenesis	23
Cystine reduces tight junction permeability and intestinal inflammation induced by oxidative stress in Caco-2 cells	21
Determination of amino acids in human biological fluids by high-performance liquid chromatography: critical review	21

PepQSAR: a comprehensive data source and information platform for peptide quantitative structure–activity relationships	20
Human cell receptors: potential drug targets to combat COVID-19	20
Protective effects of glycine against lipopolysaccharide-induced intestinal apoptosis and inflammation	20
Oxidative testicular injury: effect of l-leucine on redox, cholinergic and purinergic dysfunctions, and dysregulated metabolic pathways	20
Transglutaminase 2: a novel therapeutic target for idiopathic pulmonary fibrosis using selective small molecule inhibitors	20
Paleoproteomic profiling of organic residues on prehistoric pottery from Malta	20
Chiral resolution of plasma amino acids reveals enantiomer-selective associations with organ functions	20
The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer	20
Cortisol enhances citrulline synthesis from proline in enterocytes of suckling piglets	19
Novel antimicrobial cruzioseptin peptides extracted from the splendid leaf frog, Cruziohyla calcarifer	19
Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies	19
Taurine protects dopaminergic neurons in paraquat-induced Parkinson’s disease mouse model through PI3K/Akt signaling pathways	18
Oxidation of amino acids, glucose, and fatty acids as metabolic fuels in enterocytes of developing pigs	17
Feeding intact proteins, peptides, or free amino acids to monogastric farm animals	17
Disruption of kynurenine pathway reveals physiological importance of tryptophan catabolism in Henosepilachna vigintioctopunctata	17
Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplan	17
N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations	17
Rational design of stapled antimicrobial peptides	16
LEAP2 has antagonized the ghrelin receptor GHSR1a since its emergence in ancient fish	16
Molecular targets for antifungals in amino acid and protein biosynthetic pathways	16
Apoptosis-mediated anticancer activity in prostate cancer cells of a chestnut honey (Castanea sativa L.) quinoline–pyrrolidine gamma-lactam alkaloid	16
High performance liquid chromatography determination of l-glutamate, l-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer’s disease	16
Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?	16
Taurine ameliorates axonal damage in sciatic nerve of diabetic rats and high glucose exposed DRG neuron by PI3K/Akt/mTOR-dependent pathway	16
Dietary supplementation with monosodium glutamate enhances milk production by lactating sows and the growth of suckling piglets	16
Development, validation of a GC–MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special empha	16
Functional roles of polyamines and their metabolite acrolein in eukaryotic cells	15
Alarin alleviated cardiac fibrosis via attenuating oxidative stress in heart failure rats	15
Monitoring peptide tyrosine nitration by spectroscopic methods	15
Reprogramming of mitochondrial proline metabolism promotes liver tumorigenesis	14
Anti-inflammatory effect of l-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters	14
Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis	14
Dual effects of the tryptophan-derived bacterial metabolite indole on colonic epithelial cell metabolism and physiology: comparison with its co-metabolite indoxyl sulfate	14
Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy	14
Factors associated with elevated plasma phenylalanine in patients with heart failure	14
Profile of urinary amino acids and their post-translational modifications (PTM) including advanced glycation end-products (AGEs) of lysine, arginine and cysteine in lean and obese ZSF1 rats	14
Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy	14
Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology—part I	14
In silico identification of novel ACE and DPP-IV inhibitory peptides derived from buffalo milk proteins and evaluation of their inhibitory mechanisms	14
The introduction of l-phenylalanine into antimicrobial peptide protonectin enhances the selective antibacterial activity of its derivative phe-Prt against Gram-positive bacteria	13
Effects of N-acetylcysteine supplementation on disease activity, oxidative stress, and inflammatory and metabolic parameters in rheumatoid arthritis patients: a randomized double-blind placebo-control	13
Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent	13
Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women	13
Effects of dietary protein intake on the oxidation of glutamate, glutamine, glucose and palmitate in tissues of largemouth bass (Micropterus salmoides)	13
A mix of functional amino acids and grape polyphenols promotes the growth of piglets, modulates the gut microbiota in vivo and regulates epithelial homeostasis in intestinal organoids	13
Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides	13
The use of BCAA to decrease delayed-onset muscle soreness after a single bout of exercise: a systematic review and meta-analysis	13
Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women	13
Isocyanide-based consecutive Bargellini/Ugi reactions: an efficient method for the synthesis of pseudo-peptides containing three amide bonds	12
Effects of the l-tyrosine-derived bacterial metabolite p-cresol on colonic and peripheral cells	12

Enhanced neural differentiation of neural stem cells by sustained release of Shh from TG2 gene-modified EMSC co-culture in vitro	12
Age-related decline in the taurine content of the skin in rodents	12
Effect of l-Carnosine as adjunctive therapy in the management of children with autism spectrum disorder: a randomized controlled study	12
L-valine production in Corynebacterium glutamicum based on systematic metabolic engineering: progress and prospects	12
Polyamine synthesis from arginine and proline in tissues of developing chickens	12
Current status of PTMs structural databases: applications, limitations and prospects	12
Interference of dietary polyphenols with potentially toxic amino acid metabolites derived from the colonic microbiota	11
Plasma amino acids indicate glioblastoma with ATRX loss	11
Targeted metabolomics analysis of serum amino acid profiles in patients with Moyamoya disease	11
Tryptophan regulates bile and nitrogen metabolism in two pig gut lactobacilli species in vitro based on metabolomics study	11
Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria	11
Impact of probiotic Limosilactobacillus reuteri DSM 17938 on amino acid metabolism in the healthy newborn mouse	11
Meta-proteomic analysis of the Shandrin mammoth by EVA technology and high-resolution mass spectrometry: what is its gut microbiota telling us?	11
C-terminus amidation influences biological activity and membrane interaction of maculatin 1.1	11
Effect of L-Carnosine in children with autism spectrum disorders: a systematic review and meta-analysis of randomised controlled trials	10
Meta-proteomic analysis of two mammoth’s trunks by EVA technology and high-resolution mass spectrometry for an indirect picture of their habitat and the characterization of the collagen type I, alpha-	10
Effects of long-term taurine supplementation on age-related changes in skeletal muscle function of Sprague–Dawley rats	10
Sweroside: An iridoid glycoside of potential neuroprotective, antidiabetic, and antioxidant activities supported by molecular docking	10
Interaction of exercise training with taurine attenuates infarct size and cardiac dysfunction via Akt–Foxo3a–Caspase-8 signaling pathway	10
IHEC_RAAC: a online platform for identifying human enzyme classes via reduced amino acid cluster strategy	10
ImitateDB: A database for domain and motif mimicry incorporating host and pathogen protein interactions	10
Leucine ingestion promotes mTOR translocation to the periphery and enhances total and peripheral RPS6 phosphorylation in human skeletal muscle	10
Scope and limitations of pseudoprolines as individual amino acids in peptide synthesis	10
Targeted fluorescent imaging of a novel FITC-labeled PSMA ligand in prostate cancer	9
Fast killing kinetics, significant therapeutic index, and high stability of melittin-derived antimicrobial peptide	9
Cytoprotective effect of taurine against sodium chlorate-induced oxidative damage in human red blood cells: an ex vivo study	9
Sequence and N-glycan diversity analysis of immunoglobulin G from buffalo milk using RP-UHPLC MS/MS	9
l-Arginine increases AMPK phosphorylation and the oxidation of energy substrates in hepatocytes, skeletal muscle cells, and adipocytes	9
Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults	9
Effects of sex and estrous cycle on the brain and plasma arginine metabolic profile in rats	9
Free threonine in human breast milk is related to infant intestinal microbiota composition	9
Dietary supplementation with l-arginine between days 14 and 25 of gestation enhances NO and polyamine syntheses and the expression of angiogenic proteins in porcine placentae	9
Amino acids, post-translational modifications, nitric oxide, and oxidative stress in serum and urine of long COVID and ex COVID human subjects	9
Association between dietary essential amino acids intake and metabolic biomarkers: influence of obesity among Chinese children and adolescents	9
Changes in S-(2-succinyl)cysteine and advanced glycation end-products levels in mouse tissues associated with aging	9
Amino acids-targeted metabolomics reveals novel diagnostic biomarkers for ulcerative colitis and Crohn’s disease	9
Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients	9
Deciphering the conformational landscape of few selected aromatic noncoded amino acids (NCAAs) for applications in rational design of peptide therapeutics	9
Cholesterol-lowering effects of taurine through the reduction of ileal FXR signaling due to the alteration of ileal bile acid composition	9
Oral anserine supplementation does not attenuate type-2 diabetes or diabetic nephropathy in BTBR ob/ob mice	9