Current Medicinal Chemistry

Papers
(The TQCC of Current Medicinal Chemistry is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavir211
Metal-Organic Framework (MOF)-Based Drug Delivery142
Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges118
Zeolitic Imidazolate Frameworks (ZIF-8) for Biomedical Applications: A Review114
Recent Research on Flavonoids and their Biomedical Applications113
Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review98
Bioactive Secondary Metabolites from Endophytic Fungi93
Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development93
Polyoxometalates in Biomedicine: Update and Overview86
Comprehensive Review on Graphene Oxide for Use in Drug Delivery System84
Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents79
The Role of Zinc and Copper in Insulin Resistance and Diabetes Mellitus73
Acyclovir in the Treatment of Herpes Viruses – A Review71
The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications68
Natural Polymer-based Stimuli-responsive Hydrogels67
Antiviral Activities of Human Host Defense Peptides66
Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy58
A Review: The Anti-inflammatory, Anticancer and Antibacterial Properties of Four Kinds of Licorice Flavonoids Isolated from Licorice57
A Systematic Review on Anti-diabetic Properties of Chalcones57
The Application of Hydrogels Based on Natural Polymers for Tissue Engineering56
The Role of Matrix Gla Protein (MGP) in Vascular Calcification52
The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein52
Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease50
The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis - Current Status48
B7-H3 Immune Checkpoint Protein in Human Cancer46
Natural Polymers Based Hydrogels for Cell Culture Applications46
Cyclosporine A: Chemistry and Toxicity – A Review44
Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications44
Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review44
Advances in Pharmacological Activities and Mechanisms of Glycyrrhizic Acid43
Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints43
Anti-Coronavirus Vaccines: Past Investigations on SARS-CoV-1 and MERS-CoV, the Approved Vaccines from BioNTech/Pfizer, Moderna, Oxford/AstraZeneca and others under Development Against SARSCoV- 2 Infec43
FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment42
Inflammation as the Common Biological Link Between Depression and Cardiovascular Diseases: Can Carnosine Exert a Protective Role?42
Role of Pro-inflammatory Cytokines in Regulation of Skeletal Muscle Metabolism: A Systematic Review41
A Comprehensive Review on Oxysterols and Related Diseases40
Recent Progress of Benzimidazole Hybrids for Anticancer Potential40
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update40
Terpenes, Phenylpropanoids, Sulfur and Other Essential Oil Constituents as Inhibitors of Cholinesterases38
Deep Learning in Drug Target Interaction Prediction: Current and Future Perspectives38
Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors37
Structural Basis of Drug Recognition by Human Serum Albumin36
Central Regulatory Role of Cytokines in Periodontitis and Targeting Options35
Indole Derivatives as Anti-Tubercular Agents: An Overview on their Synthesis and Biological Activities34
Nanoparticles in Combating Cancer: Opportunities and Limitations: A Brief Review33
Metal Complexes as Promising Agents for Biomedical Applications32
Natural Anti-inflammatory Compounds as Drug Candidates in Alzheimer’s Disease32
New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door31
Metal Toxicity and Speciation: A Review31
Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects31
Recent Advances in Elucidating Paclitaxel Resistance Mechanisms in Non-small Cell Lung Cancer and Strategies to Overcome Drug Resistance31
Targeting the JAK/STAT Signaling Pathway for Breast Cancer31
Tubulin Inhibitors Binding to Colchicine-Site: A Review from 2015 to 201930
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)30
Lipids as Activators of Innate Immunity in Peptide Vaccine Delivery29
LncRNAs: Potential Novel Prognostic and Diagnostic Biomarkers in Colorectal Cancer29
Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity29
Natural Products as Potential Anti-Alzheimer Agents29
Recent Advances in Fe-MOF Compositions for Biomedical Applications29
Marine Natural Products with High Anticancer Activities28
Obesity and Body Composition in Man and Woman: Associated Diseases and the New Role of Gut Microbiota28
Neuronal Development-Related miRNAs as Biomarkers for Alzheimer's Disease, Depression, Schizophrenia and Ionizing Radiation Exposure28
Obesity Therapy: How and Why?28
The Role of Plant-Derived Compounds in Managing Diabetes Mellitus: A Review of Literature from 2014 To 201928
Autophagy Modulators and Neuroinflammation28
New Perspectives in the Pharmacological Potential of Naringin in Medicine28
A critical transcription factor NF-κB as a cancer therapeutic target and its inhibitors as cancer treatment options28
Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators27
Selective MMP-13 Inhibitors: Promising Agents for the Therapy of Osteoarthritis27
Formulation and Application of Nanoemulsions for Nutraceuticals and Phytochemicals27
1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature27
Recent Advances in Peptide-Based Approaches for Cancer Treatment26
Machine Learning Approaches in Parkinson’s Disease26
The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms26
Chitosan-Nanocellulose Composites for Regenerative Medicine Applications26
Survey of Similarity-Based Prediction of Drug-Protein Interactions26
L-carnosine and its Derivatives as New Therapeutic Agents for the Prevention and Treatment of Vascular Complications of Diabetes26
The Nitric Oxide Pathway in Pulmonary Arterial Hypertension: Pathomechanism, Biomarkers and Drug Targets26
Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies26
Monoamine Oxidase-B (MAO-B) Inhibitors in the Treatment of Alzheimer’s and Parkinson’s Disease26
The Close Interplay of Nitro-Oxidative Stress, Advanced Glycation end Products and Inflammation in Inflammatory Bowel Diseases26
Protective Role of Natural Products in Glioblastoma Multiforme: A Focus on Nitric Oxide Pathway26
Evidence of Protein Binding by a Nucleopeptide Based on a Thyminedecorated L-Diaminopropanoic Acid through CD and In Silico Studies25
Nerve Growth Factor, Stress and Diseases25
Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes25
Coronary Artery Disease and Endothelial Dysfunction: Novel Diagnostic and Therapeutic Approaches25
Small-Molecule CSF1R Inhibitors as Anticancer Agents25
Translational Theragnosis of Ovarian Cancer: where do we stand?24
The Mechanism of Action of Praziquantel: Can New Drugs Exploit Similar Mechanisms?24
Recent Advances in Multi-target Drugs Targeting Protein Kinases and Histone Deacetylases in Cancer Therapy24
Pharmacological Advances in the Treatment of Age-related Macular Degeneration24
Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy24
Anti-angiogenic Agents: A Review on Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors24
Exosome-like Nanoparticles: A New Type of Nanocarrier24
Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential23
Dietary Epicatechin, A Novel Anti-aging Bioactive Small Molecule23
Small Molecular Gemcitabine Prodrugs for Cancer Therapy23
Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art23
Romidepsin (FK228), A Histone Deacetylase Inhibitor and its Analogues in Cancer Chemotherapy23
Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder23
Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters23
Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade23
Carnosine and Diabetic Nephropathy23
Microbiota, Immune System and Autism Spectrum Disorders: An Integrative Model towards Novel Treatment Options22
Genotype Driven Therapy for Non-Small Cell Lung Cancer: Resistance, Pan Inhibitors and Immunotherapy22
The Emerging Roles of Exosomes in the Chemoresistance of Hepatocellular Carcinoma22
Discovery and Development of the Oral Complement Factor D Inhibitor Danicopan (ACH-4471)22
203/212Pb Theranostic Radiopharmaceuticals for Image-guided Radionuclide Therapy for Cancer22
Drug Repurposing: A Strategy for Discovering Inhibitors against Emerging Viral Infections22
Targeting the Endothelial Ca2+ Toolkit to Rescue Endothelial Dysfunction in Obesity Associated-Hypertension21
Endothelial Dysfunction in Dyslipidaemia: Molecular Mechanisms and Clinical Implications21
Clinical and Translational Research Challenges in Biliary Tract Cancers21
Another Look at Dietary Polyphenols: Challenges in Cancer Prevention and Treatment21
Current Scenario and Future Prospect in the Management of COVID-1921
Influence of Oxidative Stress on Catalytic and Non-glycolytic Functions of Glyceraldehyde-3-phosphate Dehydrogenase21
Thioredoxin, Glutathione and Related Molecules in Tumors of the Nervous System21
Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Monocyte/Lymphocyte Ratios in Mood Disorders21
Engineered Exosomes: A Promising Drug Delivery Strategy for Brain Diseases21
Gonadotropin-Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development21
Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Different Disease States: Recent Updates21
Recent Advances in the Rational Drug Design Based on Multi-target Ligands21
Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants21
Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis20
Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids20
Mechanistic Insights of Soluble Uric Acid-related Kidney Disease20
Diffuse Intrinsic Pontine Glioma (DIPG): Breakthrough and Clinical Perspective20
Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research20
Stimuli-responsive Drug Delivery Nanocarriers in the Treatment of Breast Cancer20
Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice20
Natural Product Inhibitors of Cyclooxygenase (COX) Enzyme: A Review on Current Status and Future Perspectives20
Sulfur-containing Secondary Metabolites as Neuroprotective Agents20
Role of microRNAs in Chronic Lymphocytic Leukemia Pathogenesis20
Targeting Mammalian Target of Rapamycin: Prospects for the Treatment of Inflammatory Bowel Diseases20
A comparative analysis on different enzyme immobilization nanomaterials: Progress, constraints, and recent trends19
Perspectives on Drug Repurposing19
The Role of Endothelial Related Circulating Biomarkers in COVID-19. A Systematic Review and Meta-analysis19
The Healing Effects of Spices in Chronic Diseases19
Monoclonal Antibodies Carried in Drug Delivery Nanosystems as a Strategy for Cancer Treatment19
Resveratrol and Prostate Cancer: The Power of Phytochemicals19
Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis19
Targeting Bacterial Antioxidant Systems for Antibiotics Development19
Enalos Suite of Tools: Enhancing Cheminformatics and Nanoinfor - matics through KNIME19
The Potential of Frog Skin Peptides for Anti-Infective Therapies: The Case of Esculentin-1a(1-21)NH219
Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders19
Biotechnological Potential of Streptomyces Siderophores as New Antibiotics19
The CXCL12-CXCR4 Signaling Axis Plays a Key Role in Cancer Metastasis and is a Potential Target for Developing Novel Therapeutics against Metastatic Cancer19
A Walk in Nature: Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways19
Curcumin: A Dietary Phytochemical for Targeting the Phenotype and Function of Dendritic Cells18
Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment18
Functional Chitosan-based Materials for Biological Applications18
The Roles of Programmed Cell Death Ligand-1/ Programmed Cell Death-1 (PD-L1/PD-1) in HPV-induced Cervical Cancer and Potential for their Use in Blockade Therapy18
Biofilm Formation as Valuable Target to Fight against Severe Chronic Infections18
Molecular Mechanism of the Canonical Oncogenic lncRNA MALAT1 in Gastric Cancer18
Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis18
Recent Advances in Asialoglycoprotein Receptor and Glycyrrhetinic Acid Receptor-Mediated and/or pH-Responsive Hepatocellular Carcinoma- Targeted Drug Delivery18
Recent Progress in Polynuclear Ruthenium Complex-Based DNA Binders/Structural Probes and Anticancer Agents18
The Chronicle of COVID-19 and Possible Strategies to Curb the Pandemic18
Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors18
Histone Deacetylases (HDACs) in Gastric Cancer: An Update of their Emerging Prognostic and Therapeutic Role18
Lactoferrin in Bone Tissue Regeneration18
OX40 and OX40L Interaction in Cancer18
Application of Machine Learning Techniques to Predict Binding Affinity for Drug Targets: A Study of Cyclin-Dependent Kinase 218
Artificial Intelligence as a Business Partner in Cardiovascular Precision Medicine: An Emerging Approach for Disease Detection and Treatment Optimization18
Cardioprotective Properties of HDL: Structural and Functional Considerations18
Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and Paraoxonase-117
Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke17
Mitochondria-Associated Membranes (MAMs): A Novel Therapeutic Target for Treating Metabolic Syndrome17
Flavonoids and PI3K/Akt/mTOR Signaling Cascade: A Potential Crosstalk in Anticancer Treatment17
Synthesis and Antioxidant Properties of Organoselenium Compounds17
Applications of Micro/Nanotechnology in Ultrasound-based Drug Delivery and Therapy for Tumor17
Fluorine-Containing Inhalation Anesthetics: Chemistry, Properties and Pharmacology17
Copper Complexes as Antitumor Agents:In vitroandIn vivoEvidence17
The Effects of Dietary Supplements that Overactivate the Nrf2/ARE System17
Hydrogels based on Natural Polymers for Medicinal Applications17
Neutrophils as Sentinel Cells of the Immune System: A Role of the MPO-halide-system in Innate and Adaptive Immunity17
Tryptophan Metabolism in Atherosclerosis and Diabetes17
Secondary Metabolites from Deep-Sea Derived Microorganisms17
Immunoconjugates for Cancer Targeting: A Review of Antibody-Drug Conjugates and Antibody-Functionalized Nanoparticles17
A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century17
Metabolic and Amino Acid Alterations of the Tumor Microenvironment17
Indole and Indoline Scaffolds in Antimicrobials: Overview, Synthesis and Recent Advances in Antimicrobial Research16
Cellulose-based Biosensor for Bio-molecules Detection in Medical Diagnosis: A Mini-Review16
Carbohydrates: Potential Sweet Tools Against Cancer16
High-Intensity Focused Ultrasound in the Treatment of Breast Cancer16
In Vitro Data of Current Therapies for SARS-CoV-216
Histone Modifications and their Role in Epigenetics of Cancer16
Immunotherapy for Uveal Melanoma - Current Knowledge and Perspectives16
Antimalarial Drug Discovery: From Quinine to the Most Recent Promising Clinical Drug Candidates16
Nanomedicine-Combined Immunotherapy for Cancer16
Risk Factors, Mechanisms and Treatments of Thromboangiitis Obliterans: An Overview of Recent Research16
The Beneficial Hemodynamic Actions of SGLT-2 Inhibitors beyond the Management of Hyperglycemia16
The Association between Depression and Gastroesophageal Reflux based on Phylogenetic Analysis of miRNA Biomarkers16
HuR as Therapeutic Target in Cancer: What the Future Holds16
Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders16
Review—Recent Advancements in Electrochemical Biosensors for Alzheimer’s Disease Biomarkers Detection16
Recent Progress on the Discovery of NLRP3 Inhibitors and their Therapeutic Potential16
Biomedical Applications of Hemicellulose-Based Hydrogels16
Meet Our Editorial Board Member15
LPS/TLR4 Pathways in Breast Cancer: Insights into Cell Signalling15
Impact of Epigenetic Alterations in the Development of Oral Diseases15
Role of Fatty Acid Binding Protein 4 (FABP4) in Kidney Disease15
Recent Advances of Chitosan and its Derivatives in Biomedical Applications15
p53: An Attractive Therapeutic Target for Cancer15
Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer’s Disease and Depression15
Ferroptosis: A Trusted Ally in Combating Drug Resistance in Cancer15
Cholecystokinin-2 Receptor Targeting with Radiolabeled Peptides: Current Status and Future Directions15
Long-Term Accumulation of Metals in the Skeleton as Related to Osteoporotic Derangements15
Research Progress in Predicting DNA Methylation Modifications and the Relation with Human Diseases15
Molecular Markers of Regulatory T Cells in Cancer Immunotherapy with Special Focus on Acute Myeloid Leukemia (AML) - A Systematic Review15
Dual-target Inhibitors Based on BRD4: Novel Therapeutic Approaches for Cancer15
Alport Syndrome: A Comprehensive Review on Genetics, Pathophysiology, Histology, Clinical and Therapeutic Perspectives15
Metabolomics-Guided Isolation of Anti-Trypanosomal Compounds from Endophytic Fungi of the Mangrove plant Avicennia Lanata15
Recent Design and Structure-Activity Relationship Studies on the Modifications of DHFR Inhibitors as Anticancer Agents15
A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases15
Mitochondria Associated Membranes (MAMs): Emerging Drug Targets for Diabetes15
The Effect of Oxidative Stress and Antioxidant Therapies on Pancreatic β-cell Dysfunction: Results from in Vitro and in Vivo Studies15
Recent Advances in the Development of Casein Kinase 1 Inhibitors15
Cubilin, the Intrinsic Factor-Vitamin B12 Receptor in Development and Disease15
Carnosine and Kidney Diseases: What We Currently Know?15
Targeting Inflammatory Mediators: An Anticancer Mechanism of Thymoquinone Action15
Quaternized Chitosan Nanoparticles in Vaccine Applications15
Trefoil Factor Family (TFF) Peptides and their Different Roles in the Mucosal Innate Immune Defense and More: An Update15
Self-assembling Peptides in Current Nanomedicine: Versatile Nanomaterials for Drug Delivery15
Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm14
Biochemical Markers in the Prediction of Contrast-induced Acute Kidney Injury14
Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility14
Electrostatic Potential Energy in Protein-Drug Complexes14
Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years14
Recent Advances in Combretastatin A-4 Inspired Inhibitors of Tubulin Polymerization: An Update14
Ultrasound-Based Drug Delivery System14
Ligand- and Structure-Based Drug Design and Optimization using KNIME14
Current Development of Metal Complexes with Diamine Ligands as Potential Anticancer Agents14
Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity14
Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance14
Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents14
Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data14
A Systematic Review of the Anti-inflammatory Effects of Gallium Compounds14
Neurokinin-1 Receptor (NK-1R) Antagonists: Potential Targets in the Treatment of Glioblastoma Multiforme14
Obesity and Cardioprotection14
Drug Repurposing: Promises of Edaravone Target Drug in Traumatic Brain Injury14
Small Molecule Inhibitors Targeting Key Proteins in the DNA Damage Response for Cancer Therapy14
Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer14
Cellular Communication in Bone Homeostasis and the Related Anti-osteoporotic Drug Development14
Targeting the NLRP3 Inflammasome in Diabetic Nephropathy14
The Role of Interleukin-6 in the Pathogenesis, Prognosis and Treatment of Severe COVID-1913
Insights into the Design of Inhibitors of the Urease Enzyme - A Major Target for the Treatment of Helicobacter pylori Infections13
Metabolic Remodeling Induced by Adipocytes: A New Achilles' Heel in Invasive Breast Cancer?13
Natural-based Hydrogels: A Journey from Simple to Smart Networks for Medical Examination13
Implantable Medical Devices and Tissue Engineering: An Overview of Manufacturing Processes and the Use of Polymeric Matrices for Manufacturing and Coating their Surfaces13
Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges13
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