Current Medicinal Chemistry

Papers
(The TQCC of Current Medicinal Chemistry is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)
ArticleCitations
Metal-Organic Framework (MOF)-Based Drug Delivery182
Zeolitic Imidazolate Frameworks (ZIF-8) for Biomedical Applications: A Review155
Recent Research on Flavonoids and their Biomedical Applications152
Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development122
The Role of Zinc and Copper in Insulin Resistance and Diabetes Mellitus100
The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis - Current Status76
Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy70
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update63
Advances in Pharmacological Activities and Mechanisms of Glycyrrhizic Acid63
Cyclosporine A: Chemistry and Toxicity – A Review59
The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein56
Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors55
A Comprehensive Review on Oxysterols and Related Diseases55
Deep Learning in Drug Target Interaction Prediction: Current and Future Perspectives52
Metal Toxicity and Speciation: A Review50
Histone Modifications and their Role in Epigenetics of Cancer49
Central Regulatory Role of Cytokines in Periodontitis and Targeting Options48
Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications48
Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review47
Recent Progress of Benzimidazole Hybrids for Anticancer Potential45
Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints45
Anti-Coronavirus Vaccines: Past Investigations on SARS-CoV-1 and MERS-CoV, the Approved Vaccines from BioNTech/Pfizer, Moderna, Oxford/AstraZeneca and others under Development Against SARSCoV- 2 Infec43
Indole Derivatives as Anti-Tubercular Agents: An Overview on their Synthesis and Biological Activities40
Targeting the JAK/STAT Signaling Pathway for Breast Cancer39
Natural Anti-inflammatory Compounds as Drug Candidates in Alzheimer’s Disease38
Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential37
Recent Advances in Elucidating Paclitaxel Resistance Mechanisms in Non-small Cell Lung Cancer and Strategies to Overcome Drug Resistance36
Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke36
Monoamine Oxidase-B (MAO-B) Inhibitors in the Treatment of Alzheimer’s and Parkinson’s Disease36
Machine Learning Approaches in Parkinson’s Disease36
Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity35
Recent Advances in Fe-MOF Compositions for Biomedical Applications35
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)34
Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Different Disease States: Recent Updates34
New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door33
Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies33
New Perspectives in the Pharmacological Potential of Naringin in Medicine33
The Role of Plant-Derived Compounds in Managing Diabetes Mellitus: A Review of Literature from 2014 To 201933
Tubulin Inhibitors Binding to Colchicine-Site: A Review from 2015 to 201932
Nerve Growth Factor, Stress and Diseases32
A critical transcription factor NF-κB as a cancer therapeutic target and its inhibitors as cancer treatment options32
Nanoparticles in Combating Cancer: Opportunities and Limitations: A Brief Review32
The Nitric Oxide Pathway in Pulmonary Arterial Hypertension: Pathomechanism, Biomarkers and Drug Targets31
Anti-angiogenic Agents: A Review on Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors30
Natural Products as Potential Anti-Alzheimer Agents30
Another Look at Dietary Polyphenols: Challenges in Cancer Prevention and Treatment29
Small Molecular Gemcitabine Prodrugs for Cancer Therapy29
Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Monocyte/Lymphocyte Ratios in Mood Disorders29
Neuronal Development-Related miRNAs as Biomarkers for Alzheimer's Disease, Depression, Schizophrenia and Ionizing Radiation Exposure29
1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature28
Romidepsin (FK228), A Histone Deacetylase Inhibitor and its Analogues in Cancer Chemotherapy28
Copper Complexes as Antitumor Agents:In vitroandIn vivoEvidence28
Protective Role of Natural Products in Glioblastoma Multiforme: A Focus on Nitric Oxide Pathway28
Survey of Similarity-Based Prediction of Drug-Protein Interactions28
Engineered Exosomes: A Promising Drug Delivery Strategy for Brain Diseases27
Protective Effects of Curcumin against Lipopolysaccharide-Induced Toxicity27
Ferroptosis: A Trusted Ally in Combating Drug Resistance in Cancer27
Artificial Intelligence as a Business Partner in Cardiovascular Precision Medicine: An Emerging Approach for Disease Detection and Treatment Optimization27
Recent Advances in Multi-target Drugs Targeting Protein Kinases and Histone Deacetylases in Cancer Therapy27
Biotechnological Potential of Streptomyces Siderophores as New Antibiotics26
Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade26
Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder26
Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis26
203/212Pb Theranostic Radiopharmaceuticals for Image-guided Radionuclide Therapy for Cancer26
Translational Theragnosis of Ovarian Cancer: where do we stand?26
A comparative analysis on different enzyme immobilization nanomaterials: Progress, constraints, and recent trends26
Natural Product Inhibitors of Cyclooxygenase (COX) Enzyme: A Review on Current Status and Future Perspectives26
Dietary Epicatechin, A Novel Anti-aging Bioactive Small Molecule26
Evidence of Protein Binding by a Nucleopeptide Based on a Thyminedecorated L-Diaminopropanoic Acid through CD and In Silico Studies26
Resveratrol and Prostate Cancer: The Power of Phytochemicals26
Diffuse Intrinsic Pontine Glioma (DIPG): Breakthrough and Clinical Perspective25
OX40 and OX40L Interaction in Cancer25
Molecular Mechanism of the Canonical Oncogenic lncRNA MALAT1 in Gastric Cancer25
Recent Advances in Asialoglycoprotein Receptor and Glycyrrhetinic Acid Receptor-Mediated and/or pH-Responsive Hepatocellular Carcinoma- Targeted Drug Delivery25
Tryptophan Metabolism in Atherosclerosis and Diabetes25
Drug Repurposing: A Strategy for Discovering Inhibitors against Emerging Viral Infections25
Perspectives on Drug Repurposing25
Indole and Indoline Scaffolds in Antimicrobials: Overview, Synthesis and Recent Advances in Antimicrobial Research24
Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors24
Structure-based Virtual Screening, Molecular Docking, Molecular Dynamics Simulation, and Metabolic Reactivity Studies of Quinazoline Derivatives for their Anti-EGFR Activity Against Tumor Angiogenesis24
Monoclonal Antibodies Carried in Drug Delivery Nanosystems as a Strategy for Cancer Treatment24
Gonadotropin-Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development24
Biofilm Formation as Valuable Target to Fight against Severe Chronic Infections24
Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders24
Synthesis and Antioxidant Properties of Organoselenium Compounds23
Risk Factors, Mechanisms and Treatments of Thromboangiitis Obliterans: An Overview of Recent Research23
LPS/TLR4 Pathways in Breast Cancer: Insights into Cell Signalling23
Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance23
Targeting Mammalian Target of Rapamycin: Prospects for the Treatment of Inflammatory Bowel Diseases23
Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis23
A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century23
The Emerging Roles of Exosomes in the Chemoresistance of Hepatocellular Carcinoma23
A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases23
Advances in Polyaniline for Biomedical Applications23
The Roles of Programmed Cell Death Ligand-1/ Programmed Cell Death-1 (PD-L1/PD-1) in HPV-induced Cervical Cancer and Potential for their Use in Blockade Therapy22
Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases22
Antimalarial Drug Discovery: From Quinine to the Most Recent Promising Clinical Drug Candidates22
Curcumin: A Dietary Phytochemical for Targeting the Phenotype and Function of Dendritic Cells22
The CXCL12-CXCR4 Signaling Axis Plays a Key Role in Cancer Metastasis and is a Potential Target for Developing Novel Therapeutics against Metastatic Cancer22
Azole Derivatives: Recent Advances as Potent Antibacterial and Antifungal Agents22
Flavonoids and PI3K/Akt/mTOR Signaling Cascade: A Potential Crosstalk in Anticancer Treatment22
Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and Paraoxonase-122
Current Scenario and Future Prospect in the Management of COVID-1922
Histone Deacetylases (HDACs) in Gastric Cancer: An Update of their Emerging Prognostic and Therapeutic Role22
Immunoconjugates for Cancer Targeting: A Review of Antibody-Drug Conjugates and Antibody-Functionalized Nanoparticles21
Cholecystokinin-2 Receptor Targeting with Radiolabeled Peptides: Current Status and Future Directions21
Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years21
The Role of Endothelial Related Circulating Biomarkers in COVID-19. A Systematic Review and Meta-analysis21
High-Intensity Focused Ultrasound in the Treatment of Breast Cancer21
Endometrial Cancer: Genetic, Metabolic Characteristics, Therapeutic Strategies and Nanomedicine21
Fluorine-Containing Inhalation Anesthetics: Chemistry, Properties and Pharmacology21
The mTOR/4E-BP1/eIF4E Signalling Pathway as a Source of Cancer Drug Targets21
Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids21
Alport Syndrome: A Comprehensive Review on Genetics, Pathophysiology, Histology, Clinical and Therapeutic Perspectives21
Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment20
Applications of Micro/Nanotechnology in Ultrasound-based Drug Delivery and Therapy for Tumor20
Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review20
Review—Recent Advancements in Electrochemical Biosensors for Alzheimer’s Disease Biomarkers Detection20
Impact of Epigenetic Alterations in the Development of Oral Diseases20
Application of Machine Learning Techniques to Predict Binding Affinity for Drug Targets: A Study of Cyclin-Dependent Kinase 219
Secondary Metabolites from Deep-Sea Derived Microorganisms19
Targeting the NLRP3 Inflammasome in Diabetic Nephropathy19
Mitochondria-Associated Membranes (MAMs): A Novel Therapeutic Target for Treating Metabolic Syndrome19
The Association between Depression and Gastroesophageal Reflux based on Phylogenetic Analysis of miRNA Biomarkers19
Gut Microbiota and Cardiovascular Disease: Symbiosis Versus Dysbiosis19
Ultrasound-Based Drug Delivery System19
The Chronicle of COVID-19 and Possible Strategies to Curb the Pandemic19
HuR as Therapeutic Target in Cancer: What the Future Holds19
Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer’s Disease19
Recent Trends in Tubulin-Binding Combretastatin A-4 Analogs for Anticancer Drug Development18
Resveratrol, a Molecule with Anti-Inflammatory and Anti-Cancer Activities: Natural Product to Chemical Synthesis18
Research Progress in Predicting DNA Methylation Modifications and the Relation with Human Diseases18
Enalos Suite of Tools: Enhancing Cheminformatics and Nanoinfor - matics through KNIME18
Overview of PROTACs Targeting the Estrogen Receptor: Achievements for Biological and Drug Discovery18
Neurokinin-1 Receptor (NK-1R) Antagonists: Potential Targets in the Treatment of Glioblastoma Multiforme18
Enzyme Replacement Therapy for Genetic Disorders Associated with Enzyme Deficiency18
Natural Sourced Inhibitors of EGFR, PDGFR, FGFR and VEGFRMediated Signaling Pathways as Potential Anticancer Agents18
Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer’s Disease and Depression18
Recent Advances in the Development of Casein Kinase 1 Inhibitors18
Metabolic and Amino Acid Alterations of the Tumor Microenvironment18
Nanomedicine-Combined Immunotherapy for Cancer17
Falcipain-2 and Falcipain-3 Inhibitors as Promising Antimalarial Agents17
C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development17
Neuropharmacology of Organoselenium Compounds in Mental Disorders and Degenerative Diseases17
GABA System in Depression: Impact on Pathophysiology and Psychopharmacology17
The Beneficial Hemodynamic Actions of SGLT-2 Inhibitors beyond the Management of Hyperglycemia17
Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity17
Beneficial Effects of Dietary Polyphenols in the Prevention and Treatment of NAFLD: Cell-Signaling Pathways Underlying Health Effects17
Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020)17
Cucurbitacins and the Immune System: Update in Research on Anti- inflammatory, Antioxidant, and Immunomodulatory Mechanisms17
Microbiome in Critical Care: An Unconventional and Unknown Ally17
The Therapeutic use of the Zonulin Inhibitor AT-1001 (Larazotide) for a Variety of Acute and Chronic Inflammatory Diseases17
Nitric Oxide and Immune Responses in Cancer: Searching for New Therapeutic Strategies16
Dual-target Inhibitors Based on BRD4: Novel Therapeutic Approaches for Cancer16
Pharmacologically Active Vanadium Species: Distribution in Biological Media and Interaction with Molecular Targets16
Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders16
A Systematic Review of the Anti-inflammatory Effects of Gallium Compounds16
Long-Term Accumulation of Metals in the Skeleton as Related to Osteoporotic Derangements16
Preparation and Applications of Superparamagnetic Iron Oxide Nanoparticles in Novel Drug Delivery Systems: An Overview16
Use of Exogenous Enzymes in Human Therapy: Approved Drugs and Potential Applications16
Trefoil Factor Family (TFF) Peptides and their Different Roles in the Mucosal Innate Immune Defense and More: An Update16
Current Phthalocyanines Delivery Systems in Photodynamic Therapy: An Updated Review16
Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm16
Drug Repurposing: Promises of Edaravone Target Drug in Traumatic Brain Injury16
Recent Design and Structure-Activity Relationship Studies on the Modifications of DHFR Inhibitors as Anticancer Agents16
Dehydrocholesterol Reductase 24 (DHCR24): Medicinal Chemistry, Pharmacology and Novel Therapeutic Options16
Regulation of Apolipoprotein B by Natural Products and Nutraceuticals: A Comprehensive Review15
Recent Progress on the Discovery of NLRP3 Inhibitors and their Therapeutic Potential15
Electrostatic Potential Energy in Protein-Drug Complexes15
Biochemical Markers in the Prediction of Contrast-induced Acute Kidney Injury15
Targeting Inflammatory Mediators: An Anticancer Mechanism of Thymoquinone Action15
Recent Advances in Combretastatin A-4 Inspired Inhibitors of Tubulin Polymerization: An Update15
Recent Advances in Paclitaxel-based Self-Delivery Nanomedicine for Cancer Therapy15
The Role of miRNAs in Metabolic Diseases15
The Correlation between Lipid Metabolism Disorders and Prostate Cancer15
Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer15
The Role of Interleukin-6 in the Pathogenesis, Prognosis and Treatment of Severe COVID-1915
Biomedical Applications of Bacterial Cellulose based Composite Hydrogels15
Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways15
Mitophagy: A Novel Therapeutic Target for Treating DN15
The Effect of Oxidative Stress and Antioxidant Therapies on Pancreatic β-cell Dysfunction: Results from in Vitro and in Vivo Studies15
Benzoxazine: A Privileged Scaffold in Medicinal Chemistry15
Discovery of Anticancer Agents from 2-Pyrazoline-Based Compounds15
Advancements within Modern Machine Learning Methodology: Impacts and Prospects in Biomarker Discovery15
Heterocycles in Breast Cancer Treatment: The Use of Pyrazole Derivatives14
Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA Targeting14
Natural Products as a Promising Therapeutic Strategy to Target Cancer Stem Cells14
Cellular Functional, Protective or Damaging Responses Associated with Different Redox Imbalance Intensities: A Comprehensive Review14
Cancer Treatments Using Low-Temperature Plasma14
An Updated Review of the Cross-talk Between MicroRNAs and Epigenetic Factors in Cancers14
The Significant Role of Nutraceutical Compounds in Ulcerative Colitis Treatment14
Role of C1QBP/p32 and its Therapeutic Potential in Breast Carcinoma and other Cancers14
Ligand- and Structure-Based Drug Design and Optimization using KNIME14
mTOR Targeted Cancer Chemoprevention by Flavonoids14
Small Molecule Inhibitors Targeting Key Proteins in the DNA Damage Response for Cancer Therapy14
Tanshinone IIA: Pharmacology, Total Synthesis, and Progress in Structure-modifications14
Advances in Biomedical Application of Nanocellulose-Based Materials: A Review14
Recent Advances in the Medicinal Chemistry of Phenothiazines, New Anticancer and Antiprotozoal Agents14
Dual Targeting Strategies on Histone Deacetylase 6 (HDAC6) and Heat Shock Protein 90 (Hsp90)14
EndMT: Potential Target of H2S against Atherosclerosis14
New Insights on Fak and Fak Inhibitors14
Essential Principles and Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging14
Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents14
Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data14
Gut Microbiota and Autoimmune Diseases: A Charming Real World Together with Probiotics14
How Zinc-Binding Systems, Expressed by Human Pathogens, Acquire Zinc from the Colonized Host Environment: A Critical Review on Zincophores14
Combination Therapy of Chemotherapy or Radiotherapy and the Neurokinin-1 Receptor Antagonist Aprepitant: A New Antitumor Strategy?13
Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part A: Two-Component Sulfonamide Hybrids13
Targeting COVID-19 in Parkinson’s Patients: Drugs Repurposed13
Selenium-Derivative Compounds: A Review of New Perspectives in the Treatment of Alzheimer’s Disease13
The Role of Alternative Toxicological Trials in Drug Discovery Programs. The Case of Caenorhabditis elegans and Other Methods13
Natural Products for the Treatment of Neurodegenerative Diseases13
Stable Gastric Pentadecapeptide BPC 157: Prompt Particular Activation of Collateral Pathways13
Effects of Polyphenols in Aging and Neurodegeneration Associated with Oxidative Stress13
The Association between Migraine and Depression based on miRNA Biomarkers and Cohort Studies13
Five Years of the KNIME Vernalis Cheminformatics Community Contribution13
miR-30e-5p Regulates Autophagy and Apoptosis by Targeting Beclin1 Involved in Contrast-induced Acute Kidney Injury13
Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD13
Histone Deacetylases and their Inhibitors in Colorectal Cancer Therapy: Current Evidence and Future Considerations13
Parthenolide and its Analogues: A New Potential Strategy for the Treatment of Triple-Negative Breast Tumors13
Sulfonamide Moiety as “Molecular Chimera” in the Design of New Drugs13
PCSK 9: A Link Between Inflammation and Atherosclerosis13
Development of Aldose Reductase Inhibitors for the Treatment of Inflammatory Disorders and Cancer: Current Drug Design Strategies and Future Directions13
Regulatory Mechanisms of Vanillic Acid in Cardiovascular Diseases: A Review13
Pulmonary Surfactant: A Unique Biomaterial with Life-saving Therapeutic Applications12
Physiological Properties, Functions, and Trends in the Matrix Metalloproteinase Inhibitors in Inflammation-Mediated Human Diseases12
The Selective NLRP3-Inflammasome Inhibitor CY-09 Ameliorates Kidney Injury in Diabetic Nephropathy by Inhibiting NLRP3- inflammasome Activation12
Gold Nanoparticles in Triple-Negative Breast Cancer Therapeutics12
Impact of Curcumin on Microsomal Enzyme Activities: Drug Interaction and Chemopreventive Studies12
Multi-targeted HDAC Inhibitors as Anticancer Agents: Current Status and Future Prospective12
Resveratrol: A New Potential Therapeutic Agent for Melanoma?12
Ghrelin Based Therapy of Metabolic Diseases12
Review about Structure and Evaluation of Reactivators of Acetylcholinesterase Inhibited with Neurotoxic Organophosphorus Compounds12
Antimicrobial Application of Chitosan Derivatives and their Nanocomposites12
Advances in L-Type Calcium Channel Structures, Functions and Molecular Modeling12
Algae as a Source of Bioactive Compounds to Prevent the Development of Type 2 Diabetes Mellitus12
Thiazole and Related Heterocyclic Systems as Anticancer Agents: A Review on Synthetic Strategies, Mechanisms of Action and SAR Studies12
Nanoparticles as a Tool for Broadening Antifungal Activities12
Chalcogenium-AZT Derivatives: A Plausible Strategy To Tackle The RT-Inhibitors-Related Oxidative Stress While Maintaining Their Anti- HIV Properties12
Potential for Novel Therapeutic Uses of Alpha Lipoic Acid12
Trends in Deep Learning for Property-driven Drug Design12
Recent Advances in the Development of CBP/p300 Bromodomain Inhibitors12
Berberine: Pharmacological Features in Health, Disease and Aging12
An Overview of Zinc Oxide Nanoparticles Produced by Plant Extracts for Anti-tuberculosis Treatments12
Biogenic Gas Vesicles for Ultrasound Imaging and Targeted Therapeutics12
Interfering with Host Proteases in SARS-CoV-2 Entry as a Promising Therapeutic Strategy12
2D Materials-Based Aptamer Biosensors: Present Status and Way Forward12
Research Progresses of Targeted Therapy and Immunotherapy for Hepatocellular Carcinoma12
Non-coding RNAs as Novel Biomarkers in Cancer Drug Resistance11
The Effect of CB1 Antagonism on Hepatic Oxidative/Nitrosative Stress and Inflammation in Nonalcoholic Fatty Liver Disease11
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