Current Medicinal Chemistry

Article	Citations
SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavir	212
Metal-Organic Framework (MOF)-Based Drug Delivery	148
Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges	122
Recent Research on Flavonoids and their Biomedical Applications	119
Zeolitic Imidazolate Frameworks (ZIF-8) for Biomedical Applications: A Review	118
Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review	103
Bioactive Secondary Metabolites from Endophytic Fungi	98
Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development	96
Comprehensive Review on Graphene Oxide for Use in Drug Delivery System	85
Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents	80
The Role of Zinc and Copper in Insulin Resistance and Diabetes Mellitus	75
Acyclovir in the Treatment of Herpes Viruses – A Review	72
Natural Polymer-based Stimuli-responsive Hydrogels	71
The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications	69
Antiviral Activities of Human Host Defense Peptides	67
Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy	59
A Review: The Anti-inflammatory, Anticancer and Antibacterial Properties of Four Kinds of Licorice Flavonoids Isolated from Licorice	59
A Systematic Review on Anti-diabetic Properties of Chalcones	57
The Application of Hydrogels Based on Natural Polymers for Tissue Engineering	56
The Role of Matrix Gla Protein (MGP) in Vascular Calcification	54
The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein	54
Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease	52
The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis - Current Status	50
Natural Polymers Based Hydrogels for Cell Culture Applications	48
B7-H3 Immune Checkpoint Protein in Human Cancer	47

Cyclosporine A: Chemistry and Toxicity – A Review	45
Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications	45
Advances in Pharmacological Activities and Mechanisms of Glycyrrhizic Acid	45
Anti-Coronavirus Vaccines: Past Investigations on SARS-CoV-1 and MERS-CoV, the Approved Vaccines from BioNTech/Pfizer, Moderna, Oxford/AstraZeneca and others under Development Against SARSCoV- 2 Infec	44
Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review	44
FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment	44
Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints	44
Role of Pro-inflammatory Cytokines in Regulation of Skeletal Muscle Metabolism: A Systematic Review	43
Inflammation as the Common Biological Link Between Depression and Cardiovascular Diseases: Can Carnosine Exert a Protective Role?	43
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update	43
A Comprehensive Review on Oxysterols and Related Diseases	42
Recent Progress of Benzimidazole Hybrids for Anticancer Potential	41
Deep Learning in Drug Target Interaction Prediction: Current and Future Perspectives	41
Central Regulatory Role of Cytokines in Periodontitis and Targeting Options	40
Terpenes, Phenylpropanoids, Sulfur and Other Essential Oil Constituents as Inhibitors of Cholinesterases	39
Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors	38
Structural Basis of Drug Recognition by Human Serum Albumin	38
Metal Toxicity and Speciation: A Review	36
Indole Derivatives as Anti-Tubercular Agents: An Overview on their Synthesis and Biological Activities	35
Nanoparticles in Combating Cancer: Opportunities and Limitations: A Brief Review	34
Metal Complexes as Promising Agents for Biomedical Applications	33
Natural Anti-inflammatory Compounds as Drug Candidates in Alzheimer’s Disease	33
Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects	32
Recent Advances in Elucidating Paclitaxel Resistance Mechanisms in Non-small Cell Lung Cancer and Strategies to Overcome Drug Resistance	32
Lipids as Activators of Innate Immunity in Peptide Vaccine Delivery	31
Targeting the JAK/STAT Signaling Pathway for Breast Cancer	31
New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door	31
Natural Products as Potential Anti-Alzheimer Agents	30
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)	30
Tubulin Inhibitors Binding to Colchicine-Site: A Review from 2015 to 2019	30
Recent Advances in Fe-MOF Compositions for Biomedical Applications	30
Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity	30
LncRNAs: Potential Novel Prognostic and Diagnostic Biomarkers in Colorectal Cancer	29
Marine Natural Products with High Anticancer Activities	29
The Role of Plant-Derived Compounds in Managing Diabetes Mellitus: A Review of Literature from 2014 To 2019	29
Autophagy Modulators and Neuroinflammation	28
Monoamine Oxidase-B (MAO-B) Inhibitors in the Treatment of Alzheimer’s and Parkinson’s Disease	28
1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature	28
New Perspectives in the Pharmacological Potential of Naringin in Medicine	28
A critical transcription factor NF-κB as a cancer therapeutic target and its inhibitors as cancer treatment options	28
Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies	28
Survey of Similarity-Based Prediction of Drug-Protein Interactions	28
Neuronal Development-Related miRNAs as Biomarkers for Alzheimer's Disease, Depression, Schizophrenia and Ionizing Radiation Exposure	28
Selective MMP-13 Inhibitors: Promising Agents for the Therapy of Osteoarthritis	27
Machine Learning Approaches in Parkinson’s Disease	27
Nerve Growth Factor, Stress and Diseases	27
Recent Advances in Peptide-Based Approaches for Cancer Treatment	27
Exosome-like Nanoparticles: A New Type of Nanocarrier	27
Chitosan-Nanocellulose Composites for Regenerative Medicine Applications	27
The Close Interplay of Nitro-Oxidative Stress, Advanced Glycation end Products and Inflammation in Inflammatory Bowel Diseases	27

Formulation and Application of Nanoemulsions for Nutraceuticals and Phytochemicals	27
L-carnosine and its Derivatives as New Therapeutic Agents for the Prevention and Treatment of Vascular Complications of Diabetes	26
The Nitric Oxide Pathway in Pulmonary Arterial Hypertension: Pathomechanism, Biomarkers and Drug Targets	26
The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms	26
Protective Role of Natural Products in Glioblastoma Multiforme: A Focus on Nitric Oxide Pathway	26
Coronary Artery Disease and Endothelial Dysfunction: Novel Diagnostic and Therapeutic Approaches	25
Translational Theragnosis of Ovarian Cancer: where do we stand?	25
Pharmacological Advances in the Treatment of Age-related Macular Degeneration	25
Carnosine and Diabetic Nephropathy	25
Evidence of Protein Binding by a Nucleopeptide Based on a Thyminedecorated L-Diaminopropanoic Acid through CD and In Silico Studies	25
Romidepsin (FK228), A Histone Deacetylase Inhibitor and its Analogues in Cancer Chemotherapy	25
Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy	25
Small-Molecule CSF1R Inhibitors as Anticancer Agents	25
Anti-angiogenic Agents: A Review on Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors	25
Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes	25
The Mechanism of Action of Praziquantel: Can New Drugs Exploit Similar Mechanisms?	25
Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters	24
Small Molecular Gemcitabine Prodrugs for Cancer Therapy	24
Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential	24
Recent Advances in Multi-target Drugs Targeting Protein Kinases and Histone Deacetylases in Cancer Therapy	24
Microbiota, Immune System and Autism Spectrum Disorders: An Integrative Model towards Novel Treatment Options	24
203/212Pb Theranostic Radiopharmaceuticals for Image-guided Radionuclide Therapy for Cancer	23
Dietary Epicatechin, A Novel Anti-aging Bioactive Small Molecule	23
Another Look at Dietary Polyphenols: Challenges in Cancer Prevention and Treatment	23
Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade	23
Discovery and Development of the Oral Complement Factor D Inhibitor Danicopan (ACH-4471)	23
Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Monocyte/Lymphocyte Ratios in Mood Disorders	23
Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder	23
Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis	22
Genotype Driven Therapy for Non-Small Cell Lung Cancer: Resistance, Pan Inhibitors and Immunotherapy	22
Engineered Exosomes: A Promising Drug Delivery Strategy for Brain Diseases	22
Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis	22
Thioredoxin, Glutathione and Related Molecules in Tumors of the Nervous System	22
Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders	22
Drug Repurposing: A Strategy for Discovering Inhibitors against Emerging Viral Infections	22
The Emerging Roles of Exosomes in the Chemoresistance of Hepatocellular Carcinoma	22
Sulfur-containing Secondary Metabolites as Neuroprotective Agents	21
Gonadotropin-Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development	21
Recent Advances in the Rational Drug Design Based on Multi-target Ligands	21
Current Scenario and Future Prospect in the Management of COVID-19	21
Endothelial Dysfunction in Dyslipidaemia: Molecular Mechanisms and Clinical Implications	21
Influence of Oxidative Stress on Catalytic and Non-glycolytic Functions of Glyceraldehyde-3-phosphate Dehydrogenase	21
Clinical and Translational Research Challenges in Biliary Tract Cancers	21
Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants	21
Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Different Disease States: Recent Updates	21
Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids	21
A comparative analysis on different enzyme immobilization nanomaterials: Progress, constraints, and recent trends	21
Natural Product Inhibitors of Cyclooxygenase (COX) Enzyme: A Review on Current Status and Future Perspectives	20
The CXCL12-CXCR4 Signaling Axis Plays a Key Role in Cancer Metastasis and is a Potential Target for Developing Novel Therapeutics against Metastatic Cancer	20
Stimuli-responsive Drug Delivery Nanocarriers in the Treatment of Breast Cancer	20
Perspectives on Drug Repurposing	20
Diffuse Intrinsic Pontine Glioma (DIPG): Breakthrough and Clinical Perspective	20
Recent Advances in Asialoglycoprotein Receptor and Glycyrrhetinic Acid Receptor-Mediated and/or pH-Responsive Hepatocellular Carcinoma- Targeted Drug Delivery	20
Targeting Bacterial Antioxidant Systems for Antibiotics Development	20
Mechanistic Insights of Soluble Uric Acid-related Kidney Disease	20
Resveratrol and Prostate Cancer: The Power of Phytochemicals	20
Biotechnological Potential of Streptomyces Siderophores as New Antibiotics	20
Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research	20
Synthesis and Antioxidant Properties of Organoselenium Compounds	20
Targeting Mammalian Target of Rapamycin: Prospects for the Treatment of Inflammatory Bowel Diseases	20
Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice	20
The Healing Effects of Spices in Chronic Diseases	19
Cardioprotective Properties of HDL: Structural and Functional Considerations	19
Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors	19
The Role of Endothelial Related Circulating Biomarkers in COVID-19. A Systematic Review and Meta-analysis	19
A Walk in Nature: Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways	19
Enalos Suite of Tools: Enhancing Cheminformatics and Nanoinfor - matics through KNIME	19
Monoclonal Antibodies Carried in Drug Delivery Nanosystems as a Strategy for Cancer Treatment	19
Copper Complexes as Antitumor Agents:In vitroandIn vivoEvidence	19
Tryptophan Metabolism in Atherosclerosis and Diabetes	19
Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke	19
The Potential of Frog Skin Peptides for Anti-Infective Therapies: The Case of Esculentin-1a(1-21)NH2	19
Curcumin: A Dietary Phytochemical for Targeting the Phenotype and Function of Dendritic Cells	19
The Roles of Programmed Cell Death Ligand-1/ Programmed Cell Death-1 (PD-L1/PD-1) in HPV-induced Cervical Cancer and Potential for their Use in Blockade Therapy	19
Mitochondria-Associated Membranes (MAMs): A Novel Therapeutic Target for Treating Metabolic Syndrome	18
A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century	18
Lactoferrin in Bone Tissue Regeneration	18
Recent Progress in Polynuclear Ruthenium Complex-Based DNA Binders/Structural Probes and Anticancer Agents	18
OX40 and OX40L Interaction in Cancer	18
The Chronicle of COVID-19 and Possible Strategies to Curb the Pandemic	18

Biofilm Formation as Valuable Target to Fight against Severe Chronic Infections	18
Review—Recent Advancements in Electrochemical Biosensors for Alzheimer’s Disease Biomarkers Detection	18
A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases	18
Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis	18
Functional Chitosan-based Materials for Biological Applications	18
Carnosine and Kidney Diseases: What We Currently Know?	18
Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and Paraoxonase-1	18
Molecular Mechanism of the Canonical Oncogenic lncRNA MALAT1 in Gastric Cancer	18
Histone Deacetylases (HDACs) in Gastric Cancer: An Update of their Emerging Prognostic and Therapeutic Role	18
Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment	18
Flavonoids and PI3K/Akt/mTOR Signaling Cascade: A Potential Crosstalk in Anticancer Treatment	18
Application of Machine Learning Techniques to Predict Binding Affinity for Drug Targets: A Study of Cyclin-Dependent Kinase 2	18
Histone Modifications and their Role in Epigenetics of Cancer	18
Artificial Intelligence as a Business Partner in Cardiovascular Precision Medicine: An Emerging Approach for Disease Detection and Treatment Optimization	18
Indole and Indoline Scaffolds in Antimicrobials: Overview, Synthesis and Recent Advances in Antimicrobial Research	17
Hydrogels based on Natural Polymers for Medicinal Applications	17
Neutrophils as Sentinel Cells of the Immune System: A Role of the MPO-halide-system in Innate and Adaptive Immunity	17
Ferroptosis: A Trusted Ally in Combating Drug Resistance in Cancer	17
Immunoconjugates for Cancer Targeting: A Review of Antibody-Drug Conjugates and Antibody-Functionalized Nanoparticles	17
Applications of Micro/Nanotechnology in Ultrasound-based Drug Delivery and Therapy for Tumor	17
The Effects of Dietary Supplements that Overactivate the Nrf2/ARE System	17
Recent Advances in the Development of Casein Kinase 1 Inhibitors	17
Carbohydrates: Potential Sweet Tools Against Cancer	17
Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance	17
The Beneficial Hemodynamic Actions of SGLT-2 Inhibitors beyond the Management of Hyperglycemia	17
Metabolic and Amino Acid Alterations of the Tumor Microenvironment	17
Secondary Metabolites from Deep-Sea Derived Microorganisms	17
Fluorine-Containing Inhalation Anesthetics: Chemistry, Properties and Pharmacology	17
Risk Factors, Mechanisms and Treatments of Thromboangiitis Obliterans: An Overview of Recent Research	16
In Vitro Data of Current Therapies for SARS-CoV-2	16
Dual-target Inhibitors Based on BRD4: Novel Therapeutic Approaches for Cancer	16
The Association between Depression and Gastroesophageal Reflux based on Phylogenetic Analysis of miRNA Biomarkers	16
Molecular Markers of Regulatory T Cells in Cancer Immunotherapy with Special Focus on Acute Myeloid Leukemia (AML) - A Systematic Review	16
Cellular Communication in Bone Homeostasis and the Related Anti-osteoporotic Drug Development	16
Quaternized Chitosan Nanoparticles in Vaccine Applications	16
Antimalarial Drug Discovery: From Quinine to the Most Recent Promising Clinical Drug Candidates	16
Nanomedicine-Combined Immunotherapy for Cancer	16
Biomedical Applications of Hemicellulose-Based Hydrogels	16
Impact of Epigenetic Alterations in the Development of Oral Diseases	16
LPS/TLR4 Pathways in Breast Cancer: Insights into Cell Signalling	16
Immunotherapy for Uveal Melanoma - Current Knowledge and Perspectives	16
Alport Syndrome: A Comprehensive Review on Genetics, Pathophysiology, Histology, Clinical and Therapeutic Perspectives	16
HuR as Therapeutic Target in Cancer: What the Future Holds	16
Cellulose-based Biosensor for Bio-molecules Detection in Medical Diagnosis: A Mini-Review	16
Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders	16
High-Intensity Focused Ultrasound in the Treatment of Breast Cancer	16
Recent Progress on the Discovery of NLRP3 Inhibitors and their Therapeutic Potential	16
Cubilin, the Intrinsic Factor-Vitamin B12 Receptor in Development and Disease	16
Research Progress in Predicting DNA Methylation Modifications and the Relation with Human Diseases	16
Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility	16
Recent Advances of Chitosan and its Derivatives in Biomedical Applications	16
Metabolomics-Guided Isolation of Anti-Trypanosomal Compounds from Endophytic Fungi of the Mangrove plant Avicennia Lanata	16
Recent Design and Structure-Activity Relationship Studies on the Modifications of DHFR Inhibitors as Anticancer Agents	16
A Systematic Review of the Anti-inflammatory Effects of Gallium Compounds	16
Metabolic Remodeling Induced by Adipocytes: A New Achilles' Heel in Invasive Breast Cancer?	15
Trefoil Factor Family (TFF) Peptides and their Different Roles in the Mucosal Innate Immune Defense and More: An Update	15
Cholecystokinin-2 Receptor Targeting with Radiolabeled Peptides: Current Status and Future Directions	15
Neurokinin-1 Receptor (NK-1R) Antagonists: Potential Targets in the Treatment of Glioblastoma Multiforme	15
Advances in Polyaniline for Biomedical Applications	15
p53: An Attractive Therapeutic Target for Cancer	15
Mitochondria Associated Membranes (MAMs): Emerging Drug Targets for Diabetes	15
Role of Fatty Acid Binding Protein 4 (FABP4) in Kidney Disease	15
Targeting Inflammatory Mediators: An Anticancer Mechanism of Thymoquinone Action	15
Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer’s Disease and Depression	15
Self-assembling Peptides in Current Nanomedicine: Versatile Nanomaterials for Drug Delivery	15
Long-Term Accumulation of Metals in the Skeleton as Related to Osteoporotic Derangements	15
The Effect of Oxidative Stress and Antioxidant Therapies on Pancreatic β-cell Dysfunction: Results from in Vitro and in Vivo Studies	15
Development of Pin1 Inhibitors and their Potential as Therapeutic Agents	14
Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review	14
Biochemical Markers in the Prediction of Contrast-induced Acute Kidney Injury	14
Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer	14
The Therapeutic use of the Zonulin Inhibitor AT-1001 (Larazotide) for a Variety of Acute and Chronic Inflammatory Diseases	14
Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases	14
Recent Advances in Combretastatin A-4 Inspired Inhibitors of Tubulin Polymerization: An Update	14
Targeting the NLRP3 Inflammasome in Diabetic Nephropathy	14
Ligand- and Structure-Based Drug Design and Optimization using KNIME	14
Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm	14
Drug Repurposing: Promises of Edaravone Target Drug in Traumatic Brain Injury	14
Electrostatic Potential Energy in Protein-Drug Complexes	14
Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years	14
Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents	14
Implantable Medical Devices and Tissue Engineering: An Overview of Manufacturing Processes and the Use of Polymeric Matrices for Manufacturing and Coating their Surfaces	14
Insights into the Design of Inhibitors of the Urease Enzyme - A Major Target for the Treatment of Helicobacter pylori Infections	14
Ultrasound-Based Drug Delivery System	14
Nitric Oxide and Immune Responses in Cancer: Searching for New Therapeutic Strategies	14
mTOR Targeted Cancer Chemoprevention by Flavonoids	14
Small Molecule Inhibitors Targeting Key Proteins in the DNA Damage Response for Cancer Therapy	14
Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity	14
Recent Trends in Tubulin-Binding Combretastatin A-4 Analogs for Anticancer Drug Development	14
Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data	14
Use of Exogenous Enzymes in Human Therapy: Approved Drugs and Potential Applications	14
Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges	14
Hydrogel-clay Nanocomposites as Carriers for Controlled Release	14
Dehydrocholesterol Reductase 24 (DHCR24): Medicinal Chemistry, Pharmacology and Novel Therapeutic Options	13
Natural-based Hydrogels: A Journey from Simple to Smart Networks for Medical Examination	13