OOIR: Observatory of International Research

Papers

(The H4-Index of Current Medicinal Chemistry is 33. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Zeolitic Imidazolate Frameworks (ZIF-8) for Biomedical Applications: A Review	155
Recent Research on Flavonoids and their Biomedical Applications	152
Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development	125
The Role of Zinc and Copper in Insulin Resistance and Diabetes Mellitus	100
The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis - Current Status	76
Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy	70
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update	66
Advances in Pharmacological Activities and Mechanisms of Glycyrrhizic Acid	63
The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein	56
Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors	55
A Comprehensive Review on Oxysterols and Related Diseases	55
Deep Learning in Drug Target Interaction Prediction: Current and Future Perspectives	52
Metal Toxicity and Speciation: A Review	50
Histone Modifications and their Role in Epigenetics of Cancer	49
Central Regulatory Role of Cytokines in Periodontitis and Targeting Options	48
Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications	48
Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review	47
Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints	45
Anti-Coronavirus Vaccines: Past Investigations on SARS-CoV-1 and MERS-CoV, the Approved Vaccines from BioNTech/Pfizer, Moderna, Oxford/AstraZeneca and others under Development Against SARSCoV- 2 Infec	43
Indole Derivatives as Anti-Tubercular Agents: An Overview on their Synthesis and Biological Activities	40
Targeting the JAK/STAT Signaling Pathway for Breast Cancer	39
Natural Anti-inflammatory Compounds as Drug Candidates in Alzheimer’s Disease	38
Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential	37
Machine Learning Approaches in Parkinson’s Disease	36
Recent Advances in Elucidating Paclitaxel Resistance Mechanisms in Non-small Cell Lung Cancer and Strategies to Overcome Drug Resistance	36

Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke	36
Monoamine Oxidase-B (MAO-B) Inhibitors in the Treatment of Alzheimer’s and Parkinson’s Disease	36
Recent Advances in Fe-MOF Compositions for Biomedical Applications	35
Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity	35
Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Different Disease States: Recent Updates	34
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)	34
The Role of Plant-Derived Compounds in Managing Diabetes Mellitus: A Review of Literature from 2014 To 2019	33
New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door	33
Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies	33
New Perspectives in the Pharmacological Potential of Naringin in Medicine	33