OOIR: Observatory of International Research

Papers

(The TQCC of Protein and Peptide Letters is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Effects of Glutathionylation on Guanylyltransferase Activity of NS5 N-terminal Capping Domain from Dengue, Japanese Encephalitis, and Zika Viruses	59
The Sensitive Genes in Response to Various Metal Ion Stresses in the Yeast Saccharomyces cerevisiae	31
Amplification of Amyloid Protein-induced Aggregation of the Eukaryotic Ribosome	15
Structural Shifts of the Parvovirus B19 Capsid Receptor-binding Domain: A Peptide Study	15
Water-soluble Moringa oleifera Seed Lectin Exhibits Monoaminergic Pathway-linked Anti-depressive-like Effects in Mice	14
Effective Plant-Derived Proteins and Peptides in Leukemia Treatment	14
Molecular Interactions of the Antimicrobial Peptide Tritrpticin with Mixed Nanoaggregates: A Fluorescence Spectroscopy Study	13
FOXN3 Expression Regulated by miR-299-5p Inhibiting the Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells	13
Understanding Protein Functions in the Biological Context	13
Heat-Shock Triggers Inverted Induction of Hypo-S-Nitrosylation and Hyper-O-GlcNAcylation	13
HSP90-regulated CHIP/TRIM21/p21 Axis Involves in the Senescence of Osteosarcoma Cells	11
Construction and Evaluation of Recombinant Chimeric Fibrillin and Elastin Fragment in Human Mesenchymal Stem Cells	11
Effect of Adipokinetic Hormone on Learning-Memory in a Scopolamine-Induced Alzheimer's Model in Mice	10
LINC01836 Promotes Colorectal Cancer Progression and Functions as ceRNA to Target SLC17A9 by Sponging miR-1226-3p	10
The Application of a Recombinant Antimicrobial Peptide of Thrombocidin-1 Expressed in Pichia pastoris as a Novel Approach Against Some Oral Pathogenic Bacteria: An In Vitro Study	10
Evaluation of the Anti-Liver Cancer Activity of Protein Fractions Isolated from Adenium obesum Leaf Extract	10
ZP3 Expression in Pancreatic Adenocarcinoma: Its Implications for the Prognosis and Therapy	10
The Implication of Hypocretin in Drug Abuse and Arousal in the Brain Stem	10
Inhibition of Canonical Wnt Signaling in Renal Cell Carcinoma Bone Metastasis: An Immunohistochemical Analysis of DKK1 and LRP5 Expression	10
Plasma/Serum Proteomics based on Mass Spectrometry	9
Increased Expression of Recombinant Chitosanase by Co-expression of Hac1p in the Yeast Pichia pastoris	9
An Overview of the Role of Membrane Proteins in Microbial Solvents Tolerance	9
Current Trends and Applications of Food-derived Antihypertensive Peptides for the Management of Cardiovascular Disease	9
Unraveling the Role of Functional Amyloids and Amyloid Peptides in Disease Detection	8
Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study	8

PLEKHG7 Expression: A Biomarker for Prognosis and Targeted Therapy in Diffuse Large B-cell Lymphoma	8
Human Serum Albumin Aggregation and its Modulation Using Nanoparticles: A Review	8
Trypsin/α-Amylase Inhibitors from Capsicum chinense Seeds: Characterization and Antifungal Activity against Fungi of Agronomic Importance	8
Comprehensive Analysis of lncRNA and mRNA Expression Profile of Macrophage RAW264.7 Stimulated by Antimicrobial Peptide BSN-37	8
SNHG3/miR-330-5p/HSD11B1 Alleviates Myocardial Ischemia-reperfusion Injury by Regulating the ERK/p38 Signaling Pathway	8
Unveiling the Molecular Mechanism of Diosmetin and its Impact on Multifaceted Cellular Signaling Pathways	7
A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease	7
Association between Higher Expression of Vav1 in Hepatocellular Carcinoma and Unfavourable Clinicopathological Features and Prognosis	7
Molecular Bases of Protein Antigenicity and Determinants of Immunogenicity, Anergy, and Mitogenicity	7
Variable Surface Antigens of Plasmodium falciparum: Protein Families with Divergent Roles	7
Binding of l-Anilino-8-Napthalenesulfonate to Free and Coformycin-Complexed Bovine Adenosine Deaminase	7
Protein Tyrosine Phosphatase Receptor-type Q: Structure, Activity, and Implications in Human Disease	7
Gelsolin Inhibits the Proliferation of Colon Cancer Cells by Enhancing the Expression of TNFR2/CASP10 as a Death Receptor Pathway	6
Neuroprotective Effect of Dexmedetomidine Pretreatment on Sevoflurane- Initiated Neurotoxicity Via the Mir-204-5p/SOX4 Axis	6
Guanidinium-based Integrated Peptide Dendrimers: Pioneer Nanocarrier in Cancer Therapy	6
Regulatory Mechanism of lncRNA CTBP1-AS2 in Nasopharyngeal Carcinoma Cell Proliferation and Apoptosis via the miR-140-5p/BMP2 Axis	6
Synthesis of Two Designed Hairprin Peptides on a Newly Developed 1,6-Hexanediol Diacrylate (HDODA)-Crosslinked Polystyrene Resin	6
Improved Soluble Expression in Escherichia coli and Easily Purified Recombinant Human Bone Morphogenetic 7-2 Fusion Protein	6
Dexmedetomidine Alleviates Brain Ischemia/Reperfusion Injury by Regulating Metastasis-associated Lung Adenocarcinoma Transcript 1/MicroRNA-140-5p/ Nuclear Factor Erythroid-derived 2-like 2 Axis	6
UPBEAT1-ROS-POD-PAL System under Different Xylogenesis Scenarios in Karelian Birch (Betula pendula Roth var. carelica (Mercl.) Hämet-Ahti)	6
P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats	6
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta	6
Neuropeptide Network of Polycystic Ovary Syndrome – A Review	6
Targeting APE1: Advancements in the Diagnosis and Treatment of Tumors	6
Preface	6
A Review on Recent Advancement in Expression Strategies Used in Bacillus subtilis	6
Lessons Learnt and the Way Forward for Drug Development Against Isocitrate Lyase from Mycobacterium tuberculosis	5
Methods of PARP-1 Determination and its Importance in Living Organisms	5
Meclofenoxate Inhibits Aggregation of Alpha-synuclein in vitro	5
Screening of MMP-2 Inhibiting Phytoconstituents for the Development of Newer Pancreatic Cancer Treatment Modalities	5
Feasibility of Domain Segmentation of B19V VP1u Using Intein Technology for Structural Studies	5
Wogonin Restrains the Malignant Progression of Lung Cancer Through Modulating MMP1 and PI3K/AKT Signaling Pathway	5
Identifying the Role of Individual Seal IAPP Amino Acids in Inhibiting the Aggregation of Human IAPP	5
Structural and Functional Analysis of Urease Accessory Protein E from Vancomycin-Resistance Staphylococcus aureus MU50 Strain	5
Knockdown of Programmed Death 1 Inhibited Progression of Papillary Thyroid Carcinoma in Mice	5
Insights into Coronavirus Papain-like Protease Structure, Function and Inhibitors	5
Unidentified N-glycans by N-glycosidase A were Identified by Nglycosidase F under Denaturing Conditions in Plant Glycoprotein	5
Cold-Induced RNA-Binding Protein and RNA-Binding Motif Protein 3: Two RNA Molecular Chaperones Closely Related to Reproductive Development and Reproductive System Diseases	5
Thermodynamics of the Association of Aminoglycoside Antibiotics with Human Angiogenin	5
Modified Levels of Renin Angiotensin Related Components in the Frontal Cortex and Hippocampus were Associated with Neuroinflammation and Lower Neuroprotective Effects of NGF During Acute Hepatic Encep	5
Preparation of IgE Antibody and Distribution of IgE+ Secretory Cells in the Palatine Tonsil of Bactrian Camel	5
Development of a Peptide-Based Multiepitope Vaccine from the SARS-CoV-2 Spike Protein for Targeted Immune Response Against COVID-19	5
Expression and Purification of His-Tagged Variants of Human Hepatitis A Virus 3C Protease	4
Characterization of a Novel Thermostable 7α-Hydroxysteroid Dehydrogenase	4
The Agonistic Activity of the Human Epidermal Growth Factor is Reduced by the D46G Substitution	4
Proteomic Analysis of the Colistin-resistant E. coli Clinical Isolate: Explorations of the Resistome	4
Applications of CRISPR Cas-9 in Ovarian Cancer Research	4
Anticancer and Antimicrobial Evaluations on Alternative Reading Frame (ARF) Peptides and their Derivatives	4
Disruption of Staphylococcus aureus Biofilms with Purified Moringa oleifera Leaf Extract Protein	4
Some Minor Characteristics of Spectrophotometric Determination of Antioxidant System and Phenolic Metabolism Enzyme Activity in Wood Plant Tissues of Pinus sylvestris L.	4

Combining Network Pharmacology, Molecular Docking and Preliminary Experiments to Explore the Mechanism of Action of FZKA Formula on Non-small Cell Lung Cancer	4
Effect of Propeptide Mutations on the Directed Evolution of Rhizomucor miehei Lipase	4
Interaction of the Seed Lectin from Parkia Platycephala (Mimosoideae) with Carbohydrates and Complex Glycans	4
The LL-37 Antimicrobial Peptide as a Treatment for Systematic Infection of Acinetobacter baumannii in a Mouse Model	4
Natural Amphibian-Derived Host Defense Peptides: Peptide Immunomodulators with Potential Therapeutic Value	4
Improving Acid-Base Pair Concentration in Wash/Elution Buffer Eliminates Elution Peak-Shouldering in Cation Exchange Chromatography	4
Preface	4
The Roles of Ciliary Neurotrophic Factor - from Neuronutrition to Energy Metabolism	4
In Silico Analysis of Natural Plant-Derived Cyclotides with Antifungal Activity against Pathogenic Fungi	4
Design, Synthesis and DNA-Binding Activities of GCN4 Peptide Dimer Studied by Circular Dichroism Spectroscopy	4
Design of Artificial C-Peptides as Potential Anti-HIV-1 Inhibitors Based on 6-HB Formation Mechanism	4
Comparison of Adjuvant Effects of Montanide ISA-720 and Heat Shock Protein 27 in Increasing Immunostimulatory Properties of HIV-1 Nef-Vif Fusion Protein Construct	4
A Functional Human Glycogen Debranching Enzyme Encoded by a Synthetic Gene: Its Implications for Glycogen Storage Disease Type III Management	4
Antimicrobial Peptides: An Overview of their Structure, Function and Mechanism of Action	4
Purification, Crystallization, and Preliminary X-ray Diffraction Studies on Hemoglobin from the Angora Goat (Capra Aegagrus Hircus)	4
Proteomic Analysis of Glucose-Induced Cardiac Myoblasts and the Potential Role of mir-92b-5p in Regulating Sarcomere Proteins Under a Hyperglycemic Environment	4
Structural Analysis Revealed the Interaction of Cardenolides from Calotropis procera with Na+/K+ ATPases from Herbivores	4
Concentration-mediated Folding and Unfolding of Collagen Triple Helix	4
Precision Enzyme: Targeted Drug Discovery in Neurodegenerative Disorders	4
Structural Properties of Rat Intestinal Fatty Acid-Binding Protein with its Dynamics: Insights into Intrinsic Disorder	3
Effect of Bromelain on Chronic Unpredictable Stress-induced Behavioral, Biochemical, and Monoamine Changes in Wistar Albino Rat Model of Depression	3
Aloperine Protects Against Cisplatin-Induced Injury in Kidney Cells Via Modulating PI3K/AKT/Nfκb-Mediated NLRP3 Inflammasome	3
Antimicrobial Activity of a Defensin-Rich Fraction from Capsicum chinense Fruits: Insights for Biotechnological Applications against Fungal Infections	3
Circ_0006789 Promotes the Progression of Hepatocellular Carcinoma Cells via Modulating miR-1324 and SOX12	3
Process Development for the Production and Purification of PEGylated RhG-CSF Expressed in Escherichia coli	3
Antioxidant Responses are Crucial for Defense against Misfolded Human Z-Type α₁-Antitrypsin	3
Expression, Purification, and Evaluation of Antibody Responses and Antibody-Immunogen Complex Simulation of a Designed Multi-Epitope Vaccine against SARS-COV-2	3
Cyclopeptide-based Anti-liver Cancer Agents: A Mini-review	3
Overview of Lignocellulolytic Enzyme Systems with Special Reference to Valorization of Lignocellulosic Biomass	3
The Role of TGFBR3 in the Development of Lung Cancer	3
Design, Expression, and Purification of a Fusion Enzyme Containing Terminal Deoxynucleotidyl Transferase from B. bovis and DNA-Binding Proteins from E. coli	3
First Display of Haloalkane Dehalogenase LinB on the Surface of Bacillus subtilis Spore	3
Corrigendum to: Neuropeptide Network of Polycystic Ovary Syndrome – A Review	3
Synthesis, Anticancer Activity, Docking Calculations and Hydrolytic Stability Studies of Bioconjugates of Monofluorenated Analogue of BIM- 23052	3
MicroRNA-605-3p Inhibited the Growth and Chemoresistance of Osteosarcoma Cells via Negatively Modulating RAF1	3
F18 Promiscuous Epitope of Acr1 Protein of Mycobacterium tuberculosis Induces the Secretion of IL-10 and Tregs but Not IL-6	3
Interaction of Synthetic Pyrethroid Insecticide Deltamethrin with Human Alpha-2-Macroglobulin: Spectroscopic and Molecular Docking Studies	3
Corrigendum to: Investigation of the Expression and Regulation of SCG5 in the Context of the Chromogranin-Secretogranin Family in Malignant Tumors	3
Development of an Autoinducible Plasmid for Recombinant Protein Production	3
Study on the Analgesic Activity of Peptide from Conus achates	3
Analysis of the Interaction of UBE2Q1 with B4GALT1 and P53: Experimental and Molecular Modeling Study	3
Optimizing Sleep in Athletes: The Potential of α-Lactalbumin in Nutrition Intervention	3
Participation of CWINV and SUS Genes in Sucrose Utilization in the Disruption of Cambium Derivatives Differentiation of Silver Birch	3
Biophysical Insight into Protein Folding, Aggregate Formation and its Inhibition Strategies	3
Structure of Cadmiull}-Substituted Phospholipase A2 from Agkistrodon halys Pallas at 2.8A Resolution	3
Polyvinyl Alcohol can Stabilize FITC Conjugated Recombinant Annexin V for Apoptotic Cells Detection	3
Wogonin and Alleviation of Hyperglycemia via Inhibition of DAG Mediated PKC Expression. A Brief Insight	3
Plant-derived Cyclotides in Immunomodulation and their TherapeuticPotential	3
Protein Arginine Methyltransferase 1 and its Dynamic Regulation Associated with Cellular Processes and Diseases	3
The Function and Modification of Human Defensin 5	3
Exploring the Potential Long-term Impact of SARS-CoV-2 on Protein Misfolding and Amyloid-related Conditions	3
Mimicking LysC Proteolysis by ‘Arginine Modification-cum-Trypsin Digestion’: Comparison of Bottom-up & Middle-down Proteomic Approaches by ESI Q-TOF MS	3
Circ_0008768 Suppresses the Pancreatic Cancer Progression via miR-330- 3p/PTEN Axis	3
Hsa_circ_0000437 Inhibits the Development of Endometrial Carcinoma through miR-626/CDKN1B Axis	3
Unlocking the Keratinolytic Potential of Brevibacillus agri Derived Keratinase: A Molecular Characterization Study	3
Estrogen Sulfotransferase SULT1E1 Expression Levels and Regulated Factors in Malignant Tumours	3
Production of Soluble Murine TRAILs in Escherichia coli with Zn²⁺ Supplementation	3
Biochemical Aspects of the Spiral Grain Formation in Scots Pine (Pinus Sylvestris L.) Wood. Some Differences and Similarities with Biochemical Indicators of Abnormal Xylogenesis in Karelian Birch (Bet	3
Exploring the Cell Wall and Secretory Proteins of Mycobacterium leprae as Biomarkers	3