OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Gene Therapy is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Reducing the risks of nuclear war—the role of health professionals	137
Use of CRISPR-based screens to identify mechanisms of chemotherapy resistance	134
Defining treatment-resistant brain cancer: Genetic screening to identify oncogene-driven immunomodulation and therapy resistance	125
Correction to: Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis	119
Platelet activation: a barrier to effective antitumor immunity	104
ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy	79
Characteristics and developmental trajectory of clinical trials focused on tumor-infiltrating lymphocytes for cancer treatment	77
Small extracellular vesicle TGF-β in cancer progression and immune evasion	70
Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X	66
Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma	65
P38 kinase in gastrointestinal cancers	56
Application of CAR-T therapy in solid tumors: current opportunities and challenges	52
Ending nuclear weapons, before they end us	48
Unveiling the role of the extracellular matrix in the osteosarcoma tumor microenvironment through integrated transcriptomics and experimental validation	46
Pan-cancer oncogenic properties and therapeutic potential of SF3B4	45
Role of non-coding RNAs in neuroblastoma	45
Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer	42
Self-replicating messenger RNA based cancer immunotherapy	40
NRAV promotes HCC stemness via the m6A-regulated let-7c-5p/LIN28B axis	38
CircPKN2 promotes ferroptosis in bladder cancer by promoting the ubiquitination of Stearoyl-CoA Desaturase 1	37
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells	36
Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis	35
PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma	34
Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy	33
circXRCC5 foster gastric cancer growth and metastasis by the HNRNPC/circXRCC5/miR-655-3p/RREB1/UBA2 positive feedback loop	31

Real-world outcomes of Adjuvant De Gramont versus Xelox chemotherapy in reSected gasTric cancER: a propensity score-matched analysis (ASTER study)	31
LncRNA CALML3-AS1 modulated by m6A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression	31
Bacillus Calmette-Guerin induces CD8+ T cell infiltration and suppresses tumor progression in microsatellite stable colorectal cancer by downregulating ARID1A	30
Correction to: Lycium barbarum glycopeptide targets PER2 to inhibit lipogenesis in glioblastoma by downregulating SREBP1c	29
CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages	29
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication	28
Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent Glioblastoma	28
BCL-xL dependency in chromophobe renal cell carcinoma	28
Targeted inactivation of EWSR1 : : FLI1 gene in Ewing sarcoma via CRISPR/Cas9 driven by an Ewing-specific GGAA promoter	27
The target atlas for antibody-drug conjugates across solid cancers	26
Exploring RNA biology in pseudomyxoma peritonei uncovers splicing dysregulation as a novel, targetable molecular vulnerability	26
NRF2-SOX4 complex regulates PSPH in hepatocellular carcinoma and modulates M2 macrophage differentiation	26
WTAP stabilized by USP7 contributes to enzalutamide resistance in prostate cancer via mediating AKT m6A-modification	26
Identification of HDAC4 as a potential therapeutic target and prognostic biomarker for ZFTA-fused ependymomas	26
Suppression of FOXO1 activity by SIRT1-mediated deacetylation weakening the intratumoral androgen autocrine function in glioblastoma	25
A conditionally replicative adenovirus vector containing the synNotch receptor gene for the treatment of muscle-invasive bladder cancer	25
LOXL1-AS1 inhibits JAK2 ubiquitination and promotes cholangiocarcinoma progression through JAK2/STAT3 signaling	24
Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification	24
EZH1/2 as targets for cancer therapy	23
SMAD4-armed oncolytic adenovirus therapy potentiates the chemotherapy effects in NSCLC through suppression of the Wnt/β-catenin pathway	23
The FOSB-IGFBP5-IGF-1 axis: a novel regulatory pathway that suppresses prostate cancer growth	22
Retraction Note: Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting	22
CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process	22
BETA prime: a first-in-man phase 1 study of AdAPT-001, an armed oncolytic adenovirus for solid tumors	21
Editorial Expression of Concern: p73β-expressing recombinant adenovirus: a potential anticancer agent	21
Editorial Expression of Concern: E1A-induced apoptosis does not prevent replication of adenoviruses with deletion of E1b in majority of infected cancer cells	21
Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway	20
Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse	20
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma	20
Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer	20
Landscape and functional impact of variants of unknown significance of immune response genes in human cancer	20
m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1	20
Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction	20
HIF-1α/IL-8 axis in hypoxic macrophages promotes esophageal cancer progression by enhancing PD-L1 expression	19
A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma	19
Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway	19
IER3: exploring its dual function as an oncogene and tumor suppressor	19
Hidden patterns of gene expression provide prognostic insight for colorectal cancer	19
ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer	19
Reversible downregulation of MYC in a spheroid model of metastatic epithelial ovarian cancer	19
Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis	19
METTL3 promotes the malignancy of non-small cell lung cancer by N6-methyladenosine modifying SFRP2	18
p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy	18
Knock-out of 5-lipoxygenase in overexpressing tumor cells—consequences on gene expression and cellular function	18
Pleiotropic mechanisms of cancer-associated fibroblast-mediated resistance in hepatocellular carcinoma: emerging therapeutic vulnerabilities and targeting strategies	18
Extracellular vesicles released by glioma cells are decorated by Annexin A2 allowing for cellular uptake via heparan sulfate	18
Chimeric Ad5/35 oncolytic adenovirus overcome preexisting neutralizing antibodies and enhance tumor targeting efficiency	18
Structural regulation of PLK1 activity: implications for cell cycle function and drug discovery	18
Glimmers of hope for targeting oncogenic KRAS-G12D	18
Blocking tri-methylguanosine synthase 1 (TGS1) stops anchorage-independent growth of canine sarcomas	17

CRISPR-Cas gene knockouts to optimize engineered T cells for cancer immunotherapy	17
WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer	17
Therapeutic potential of synthetic microRNA mimics based on the miR-15/107 consensus sequence	17
Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia	17
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice	17
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma	16
MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts	16
CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR	16
Effective delivery of genome editor to cervical cancer targeting Mcl1 for cancer therapy	16
FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner	16
SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation	16
TFF3 sensitizes cervical carcinoma cells to cisplatin toxicity by binding to IGF2R	16
Utilizing nullomers in cell-free RNA for early cancer detection	16
GPR107: A key driver of breast cancer invasion and metastasis through collagen IV modulation	15
Global characterization of megakaryocytes in bone marrow, peripheral blood, and cord blood by single-cell RNA sequencing	15
Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus	15
Correction: Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway	15
Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy	15
Correction to: Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression	15
TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling	14
MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response	14
Gastrointestinal infections and gastrointestinal haemorrhage are underestimated but serious adverse events in chimeric antigen receptor T-cell recipients: A real-world study	14
GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway	14
The long-term effectiveness and mechanism of oncolytic virotherapy combined with anti-PD-L1 antibody in colorectal cancer patient	14
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway	14
Correction to: Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway	14
RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma	14
An alternative fully human anti-BCMA CAR-T shows response for relapsed or refractory multiple myeloma with anti-BCMA CAR-T exposures previously	14
HPV status represents dominant trait driving delineation of survival-associated gene co-expression networks in head and neck cancer	14
STAT5a and SH2B3 novel mutations display malignancy roles in a triple-negative primary myelofibrosis patient	14
Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer	13
Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma	13
Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens	13
Engineered L-asparaginase variants with enhanced therapeutic properties to improve treatment of childhood acute lymphatic leukemia	13
Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells	13
Microbiota in tumors: new factor influencing cancer development	13
Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines	13
Clathrin-associated SCYL2 contributes to the activation of PI3K/AKT signaling and tumorigenesis through PTEN phosphorylation in adult T-cell leukemia/lymphoma	13
SPARC family proteins: matricellular modulators of cancer progression and therapeutic resistance	13
Integration of humanized ROBO1 CAR in PD-1 locus in natural killer cells delivers synergistic tumor-killing effect against non-small cell lung cancer	13
Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition	13
A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation	13
Estrogen receptor status heterogeneity in breast cancer tumor: role in response to endocrine treatment	12
Retraction Note: microRNA-133a exerts tumor suppressive role in oral squamous cell carcinoma through the Notch signaling pathway via downregulation of CTBP2	12
New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene	12
Correction: Pan-cancer oncogenic properties and therapeutic potential of SF3B4	12
Olfactomedin 4 produces dysplasia but suppresses metastasis of colon cancer	12
GAS5 attenuates the malignant progression of glioma stem-like cells by promoting E-cadherin	12
m6A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis	12
Activating NRF2E79Q mutation alters the differentiation of human non-small cell lung cancer	12
Editorial Expression of Concern: Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells	12
Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents	12
Correction: Hedyotis diffusae Herba-Andrographis Herba inhibits the cellular proliferation of nasopharyngeal carcinoma and triggers DNA damage through activation of p53 and p21	12
Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model	12
Therapeutic targeting of the tryptophan-kynurenine-aryl hydrocarbon receptor pathway with apigenin in MED12-mutant leiomyoma cells	12
Anti-leukemia effects of omipalisib in acute myeloid leukemia: inhibition of PI3K/AKT/mTOR signaling and suppression of mitochondrial biogenesis	12
Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent m	12
Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative colitis-associated colorectal cancer and MMP1 as a potential therapeutic target	11
RUNX1A isoform is overexpressed in acute myeloid leukemia and is associated with FLT3 internal tandem duplications	11
GTF2E2 downregulated by miR-340-5p inhibits the malignant progression of glioblastoma	11
Has_circ_ASH1L acts as a sponge for miR-1254 to promote the malignant progression of cervical cancer by targeting CD36	11
Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy	11
Oleuropein regulates ubiquitination-mediated Mcl-1 turnover and exhibits antitumor activity	11
Cleavage and polyadenylation machinery as a novel targetable vulnerability for human cancer	11
The dual role of GPX4 in breast cancer: mechanisms of therapeutic resistance and potential for novel targeted therapies	11
Methylstat sensitizes ovarian cancer cells to PARP-inhibition by targeting the histone demethylases JMJD1B/C	11
Suicide gene strategies applied in ovarian cancer studies	11
Identification of a novel prognostic ADME-related signature associated with tumor immunity for aiding therapy in head and neck squamous cell carcinoma	11
Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion	11
Long non-coding RNAs and signaling networks in non-small cell lung cancer: mechanistic insights into tumor pathogenesis	11
Atypical phosphatase DUSP11 inhibition promotes nc886 expression and potentiates gemcitabine-mediated cell death through NF-kB modulation	11