Cancer Gene Therapy

Article	Citations
Reviewer Recognition	201
Retraction Note: Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2	106
Retraction Note: Upregulating microRNA-498 inhibits gastric cancer proliferation invasion and chemoresistance through inverse interaction of Bmi1	83
Retraction Note: MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma	63
Retraction Note: VP2 capsid domain of the H-1 parvovirus determines susceptibility of human cancer cells to H-1 viral infection	60
Reducing the risks of nuclear war—the role of health professionals	59
Exploring metabolic reprogramming in esophageal cancer: the role of key enzymes in glucose, amino acid, and nucleotide pathways and targeted therapies	54
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas	51
Therapeutic efficacy of the novel SHP2 degrader SHP2-D26, alone or in combination, against lung cancer is associated with modulation of p70S6K/S6, Bim and Mcl-1	43
Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4	41
Targeting CLK4 inhibits the metastasis and progression of breast cancer by inactivating TGF-β pathway	39
RETRACTED ARTICLE: MiR-151-3p transferred by cancer-associated fibroblast-derived extracellular vesicles promotes osteosarcoma progression through the CHL1/integrin 1β/TGF-β axis	38
The KRAS-G12C inhibitor: activity and resistance	37
RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential	34
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway	33
P38 kinase in gastrointestinal cancers	32
Small extracellular vesicle TGF-β in cancer progression and immune evasion	30
FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner	30
Therapeutic applications of local injection of hsa-miR-634 into canine spontaneous malignant melanoma tumors	30
MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts	29
M2 macrophage exosomal LINC01001 promotes non-small cell lung cancer development by affecting METTL3 and glycolysis pathway	29
A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT	29
Correction: TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas	27
An alternative fully human anti-BCMA CAR-T shows response for relapsed or refractory multiple myeloma with anti-BCMA CAR-T exposures previously	27
ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy	26

STAT5a and SH2B3 novel mutations display malignancy roles in a triple-negative primary myelofibrosis patient	25
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy	24
Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT	24
Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment	24
Modification of the tumor microenvironment enhances immunity with plasmid gene therapy	23
Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression	23
Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathway	23
Role of MARK2 in the nervous system and cancer	23
m6A reader IGF2BP2 promotes lymphatic metastasis by stabilizing DPP4 in papillary thyroid carcinoma	22
Gastrointestinal infections and gastrointestinal haemorrhage are underestimated but serious adverse events in chimeric antigen receptor T-cell recipients: A real-world study	22
The long-term effectiveness and mechanism of oncolytic virotherapy combined with anti-PD-L1 antibody in colorectal cancer patient	22
miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression	22
SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer	22
RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma	21
Correction: SPRTN is involved in hepatocellular carcinoma development through the ER stress response	21
Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis	21
TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling	21
IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway	21
Caveolin-1 knockout mitigates breast cancer metastasis to the lungs via integrin α3 dysregulation in 4T1-induced syngeneic breast cancer model	20
Pathophysiological role of ion channels and transporters in hepatocellular carcinoma	20
Mesothelin expression correlates with elevated inhibitory immune activity in patients with colorectal cancer	20
GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway	19
YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma	19
SIX3 function in cancer: progression and comprehensive analysis	19
Correction to: Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis	19
Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness	19
Global characterization of megakaryocytes in bone marrow, peripheral blood, and cord blood by single-cell RNA sequencing	18
Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis	18
Correction to: MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state	18
Next generation self-replicating RNA vectors for vaccines and immunotherapies	18
Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor	18
Correction to: Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway	17
Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma	17
FUT6 inhibits the proliferation, migration, invasion, and EGF-induced EMT of head and neck squamous cell carcinoma (HNSCC) by regulating EGFR/ERK/STAT signaling pathway	17
ARID2 suppression promotes tumor progression and upregulates cytokeratin 8, 18 and β-4 integrin expression in TP53-mutated tobacco-related oral cancer and has prognostic implications	17
DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP	16
Correction to: Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression	16
Correction to: An investigation of Sigma-1 receptor expression and ligand-induced endoplasmic reticulum stress in breast cancer	16
The cross-talk of cancer-associated fibroblasts assist in prognosis and immunotherapy in patients with breast carcinoma	15
Correction: Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4	15
NCBP2 and TFRC are novel prognostic biomarkers in oral squamous cell carcinoma	14
Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X	14
MCPIP1 Suppresses the NF-κB Signaling Pathway Through Negative Regulation of K63-Linked Ubiquitylation of TRAF6 in Colorectal Cancer	14
Single-cell discovery of the scene and potential immunotherapeutic target in hypopharyngeal tumor environment	14
Cytoplasmic localization of IRF5 induces Wnt5a/E-cadherin degradation and promotes gastric cancer cells metastasis	14
HPV status represents dominant trait driving delineation of survival-associated gene co-expression networks in head and neck cancer	14
Proteomic time course of breast cancer cells highlights enhanced sensitivity to Stat3 and Src inhibitors prior to endocrine resistance development	14
SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation	14
MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo	13
Use of CRISPR-based screens to identify mechanisms of chemotherapy resistance	13

Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression	13
Acute myeloid leukemia cell-derived extracellular vesicles carrying microRNA-548ac regulate hematopoietic function via the TRIM28/STAT3 pathway	13
Correction: Cancer-associated fibroblasts: overview, progress, challenges, and directions	13
Long-term response to autologous anti-CD19 chimeric antigen receptor T cells in relapsed or refractory B cell acute lymphoblastic leukemia: a systematic review and meta-analysis	13
Cannabinoids orchestrate cross-talk between cancer cells and endothelial cells in colorectal cancer	13
PCA3 controls chromatin organization and p53 signal activation by regulating LAP2α-lamin A complexes	13
Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin	13
Publisher Correction: Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma	13
RETRACTED ARTICLE: Targeting KDM1B-dependent miR-215-AR-AGR2-axis promotes sensitivity to enzalutamide-resistant prostate cancer	13
Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis	13
Correction: UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53	13
Transcription factor p53-mediated activation of miR-519d-3p and downregulation of E2F1 attenuates prostate cancer growth and metastasis	13
Correction: Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin	13
Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways	12
Adeno-associated virus-delivered alpha synuclein inhibits bladder cancer growth via the p53/p21 signaling pathway	12
Suppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction	12
Homeostatic cytokines tune naivety and stemness of cord blood-derived transgenic T cells	12
NCOA3, a new player in melanoma susceptibility and a therapeutic target	12
Correction: Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation	12
Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus	12
Alternative splicing events in tumor immune infiltration in renal clear cell carcinomas	12
BAG2, MAD2L1, and MDK are cancer-driver genes and candidate targets for novel therapies in malignant pleural mesothelioma	12
Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene	12
Retraction Note: Circular RNA hsa_circ_0009172 suppresses gastric cancer by regulation of microRNA-485-3p-mediated NTRK3	11
Correction: Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway	11
Oncolytic virus encoding 4-1BBL and IL15 enhances the efficacy of tumor-infiltrating lymphocyte adoptive therapy in HCC	11
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner	11
BAIAP2L2 promotes the malignancy of hepatocellular carcinoma via GABPB1-mediated reactive oxygen species imbalance	11
PIK3CA mutation fortifies molecular determinants for immune signaling in vascular cancers	11
Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy	11
Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis	11
Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation	11
Long noncoding RNA LINC01291 promotes the aggressive properties of melanoma by functioning as a competing endogenous RNA for microRNA-625-5p and subsequently increasing IGF-1R expression	10
Elevated GIGYF2 expression suppresses tumor migration and enhances sensitivity to temozolomide in malignant glioma	10
Cytokine-enhanced cytolytic activity of exosomes from NK Cells	10
Human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p inhibits progression of human endometrial cancer cells through downregulating MEST	10
Correction: Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2	10
The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs	10
Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy	10
Publisher Correction: Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia-inducible factor-1α (HIF-1α) in support of spermatogenesis and tumorigenesis	10
Expressed prognostic biomarkers for primary prostate cancer independent of multifocality and transcriptome heterogeneity	10
RETRACTED ARTICLE: Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9	10
Recent advances in immune therapies for gastric cancer	10
Overexpression of microRNA-130a represses uveal melanoma cell migration and invasion through inactivation of the Wnt/β-catenin signaling pathway by downregulating USP6	10
Intrinsic S phase checkpoint enforced by an antiproliferative oncosuppressor cytokine	10
Targeting GNAQ/11 through PKC inhibition in uveal melanoma	10
Therapeutic utility of engineered myeloid cells in the tumor microenvironment	10
Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling	9
Use of CAR T-cell for acute lymphoblastic leukemia (ALL) treatment: a review study	9
Identification of an immune gene-associated prognostic signature in patients with bladder cancer	9
c-Myc-induced long noncoding RNA MIRE cooperates with hnRNPK to stabilize ELF2 mRNA and promotes clear cell renal cell carcinogenesis	9
Production of an interleukin-10 blocking antibody by genetically engineered macrophages increases cancer cell death in human gastrointestinal tumor slice cultures	9
Research progress and application of single-cell sequencing in head and neck malignant tumors	9
Somatic copy number alteration predicts clinical benefit of lung adenocarcinoma patients treated with cytokine-induced killer plus chemotherapy	9
Vector engineering, strategies and targets in cancer gene therapy	9
Blocked metabotropic glutamate receptor 5 enhances chemosensitivity in hepatocellular carcinoma and attenuates chemotoxicity in the normal liver by regulating DNA damage	9
Ribosomal S6 protein kinase 4 promotes resistance to EZH2 inhibitors in glioblastoma	9
Arvanil induces ferroptosis of hepatocellular carcinoma by binding to MICU1	9
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer	9
SUMOylation inhibition enhances multiple myeloma sensitivity to lenalidomide	9
Cutting both ways: the innate immune response to oncolytic virotherapy	9
A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA	9
Tafazzin mediates tamoxifen resistance by regulating cellular phospholipid composition in ER-positive breast cancer	9
Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis	9
CircPKN2 promotes ferroptosis in bladder cancer by promoting the ubiquitination of Stearoyl-CoA Desaturase 1	8
Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m6A-modified PTEN mRNA in pancreatic ductal adenocarcinoma	8
Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform	8
NF-κB-activated oncogene inhibition strategy for cancer gene therapy	8
A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation	8
Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines	8
Microbiota in tumors: new factor influencing cancer development	8
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels	8
Baicalein inhibits cell proliferation and induces apoptosis in brain glioma cells by downregulating the LGR4-EGFR pathway	8
N6-methyladenosine modification of RIMS binding protein 2 promotes head and neck squamous cell carcinoma proliferation and radiotherapy tolerance through endoplasmic reticulum stress	8
Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer	8
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells	8
MISEV2023: Shaping the Future of EV Research by Enhancing Rigour, Reproducibility and Transparency	8
Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification	8
The splicing factor SF3B1 confers ferroptosis resistance and promotes lung adenocarcinoma progression via upregulation of SLC7A11	8
Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells	8

UGT1A7 altered HER2-positive breast cancer response to trastuzumab by affecting epithelial-to-mesenchymal transition: A potential biomarker to identify patients resistant to trastuzumab treatment	8
Schwann cell derived pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma	8
Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens	8