OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Gene Therapy is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Reducing the risks of nuclear war—the role of health professionals	116
Homeostatic cytokines tune naivety and stemness of cord blood-derived transgenic T cells	93
Correction to: Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis	73
Correction: UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53	70
Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma	66
ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy	62
Adeno-associated virus-delivered alpha synuclein inhibits bladder cancer growth via the p53/p21 signaling pathway	53
Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X	51
Small extracellular vesicle TGF-β in cancer progression and immune evasion	49
P38 kinase in gastrointestinal cancers	46
Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis	45
Use of CRISPR-based screens to identify mechanisms of chemotherapy resistance	45
Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer	43
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells	43
CircPKN2 promotes ferroptosis in bladder cancer by promoting the ubiquitination of Stearoyl-CoA Desaturase 1	40
Correction to: FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis	34
Role of non-coding RNAs in neuroblastoma	33
Expressed prognostic biomarkers for primary prostate cancer independent of multifocality and transcriptome heterogeneity	32
PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma	32
Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence	31
Self-replicating messenger RNA based cancer immunotherapy	30
SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells	30
Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy	30
The target atlas for antibody-drug conjugates across solid cancers	27
Oncolytic adenoviruses synergistically enhance anti-PD-L1 and anti-CTLA-4 immunotherapy by modulating the tumour microenvironment in a 4T1 orthotopic mouse model	26

Pathophysiological role of ion channels and transporters in HER2-positive breast cancer	26
Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer	26
Targeted inactivation of EWSR1 : : FLI1 gene in Ewing sarcoma via CRISPR/Cas9 driven by an Ewing-specific GGAA promoter	26
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication	25
Correction: Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment	25
Enhanced antitumor immune response in melanoma tumor model by anti-PD-1 small interference RNA encapsulated in nanoliposomes	25
Correction to: Lycium barbarum glycopeptide targets PER2 to inhibit lipogenesis in glioblastoma by downregulating SREBP1c	25
CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages	24
Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent Glioblastoma	24
circXRCC5 foster gastric cancer growth and metastasis by the HNRNPC/circXRCC5/miR-655-3p/RREB1/UBA2 positive feedback loop	24
Aberrant DNA methylation impacts HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemia	24
Evaluation of the stability and intratumoral delivery of foreign transgenes encoded by an oncolytic Foamy Virus vector	23
LncRNA CALML3-AS1 modulated by m6A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression	22
m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer	22
Exploring RNA biology in pseudomyxoma peritonei uncovers splicing dysregulation as a novel, targetable molecular vulnerability	21
Identification of HDAC4 as a potential therapeutic target and prognostic biomarker for ZFTA-fused ependymomas	21
Editorial Expression of Concern: E1A-induced apoptosis does not prevent replication of adenoviruses with deletion of E1b in majority of infected cancer cells	21
Editorial Expression of Concern: p73β-expressing recombinant adenovirus: a potential anticancer agent	21
Retraction Note: Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting	20
BETA prime: a first-in-man phase 1 study of AdAPT-001, an armed oncolytic adenovirus for solid tumors	20
A conditionally replicative adenovirus vector containing the synNotch receptor gene for the treatment of muscle-invasive bladder cancer	19
Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification	19
CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy	19
Suppression of FOXO1 activity by SIRT1-mediated deacetylation weakening the intratumoral androgen autocrine function in glioblastoma	19
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma	19
Diving into the dark kinome: lessons learned from LMTK3	18
EZH1/2 as targets for cancer therapy	18
Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway	17
LOXL1-AS1 inhibits JAK2 ubiquitination and promotes cholangiocarcinoma progression through JAK2/STAT3 signaling	17
m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1	17
Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction	16
Knock-out of 5-lipoxygenase in overexpressing tumor cells—consequences on gene expression and cellular function	16
CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process	16
Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway	16
Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer	15
METTL3 promotes the malignancy of non-small cell lung cancer by N6-methyladenosine modifying SFRP2	15
Extracellular vesicles released by glioma cells are decorated by Annexin A2 allowing for cellular uptake via heparan sulfate	15
RETRACTED ARTICLE: Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting	15
Downregulation of TMEM220 promotes tumor progression in Hepatocellular Carcinoma	14
ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer	14
p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy	14
Reversible downregulation of MYC in a spheroid model of metastatic epithelial ovarian cancer	14
IER3: exploring its dual function as an oncogene and tumor suppressor	14
Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse	14
Hidden patterns of gene expression provide prognostic insight for colorectal cancer	14
Chimeric Ad5/35 oncolytic adenovirus overcome preexisting neutralizing antibodies and enhance tumor targeting efficiency	14
A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma	14
Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis	13
Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia	13
Therapeutic potential of synthetic microRNA mimics based on the miR-15/107 consensus sequence	13

Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses	13
NrCAM secreted by endometrial stromal cells enhances the progestin sensitivity of endometrial cancer cells through epigenetic modulation of PRB	13
HIF-1α/IL-8 axis in hypoxic macrophages promotes esophageal cancer progression by enhancing PD-L1 expression	13
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice	13
WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer	13
Correction to: Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression	13
CRISPR-Cas gene knockouts to optimize engineered T cells for cancer immunotherapy	13
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma	13
Glimmers of hope for targeting oncogenic KRAS-G12D	13
CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR	13
SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation	13
METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression	13
Utilizing nullomers in cell-free RNA for early cancer detection	13
MiR-181c sensitizes ovarian cancer cells to paclitaxel by targeting GRP78 through the PI3K/Akt pathway	13
Tumor suppressor immune gene therapy to reverse immunotherapy resistance	13
Blocking tri-methylguanosine synthase 1 (TGS1) stops anchorage-independent growth of canine sarcomas	13
STAT5a and SH2B3 novel mutations display malignancy roles in a triple-negative primary myelofibrosis patient	12
DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP	12
Correction to: Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway	12
Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy	12
FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner	12
Global characterization of megakaryocytes in bone marrow, peripheral blood, and cord blood by single-cell RNA sequencing	12
RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma	12
An alternative fully human anti-BCMA CAR-T shows response for relapsed or refractory multiple myeloma with anti-BCMA CAR-T exposures previously	12
HPV status represents dominant trait driving delineation of survival-associated gene co-expression networks in head and neck cancer	12
Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus	12
Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways	12
TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling	12
Correction: Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway	12
MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts	12
The long-term effectiveness and mechanism of oncolytic virotherapy combined with anti-PD-L1 antibody in colorectal cancer patient	12
Gastrointestinal infections and gastrointestinal haemorrhage are underestimated but serious adverse events in chimeric antigen receptor T-cell recipients: A real-world study	12
Estrogen receptor status heterogeneity in breast cancer tumor: role in response to endocrine treatment	11
Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition	11
Somatic copy number alteration predicts clinical benefit of lung adenocarcinoma patients treated with cytokine-induced killer plus chemotherapy	11
Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines	11
Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens	11
RETRACTED ARTICLE: Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9	11
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway	11
A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation	11
A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer	11
Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through global changes in gene expression and JNK activation	11
GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway	11
Correction: microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner	11
Retraction Note: microRNA-133a exerts tumor suppressive role in oral squamous cell carcinoma through the Notch signaling pathway via downregulation of CTBP2	10
Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma	10
m6A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis	10
GAS5 attenuates the malignant progression of glioma stem-like cells by promoting E-cadherin	10
Anti-leukemia effects of omipalisib in acute myeloid leukemia: inhibition of PI3K/AKT/mTOR signaling and suppression of mitochondrial biogenesis	10
Microbiota in tumors: new factor influencing cancer development	10
Olfactomedin 4 produces dysplasia but suppresses metastasis of colon cancer	10
Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model	10
Systems analysis identifies endothelin 1 axis blockade for enhancing the anti-tumor effect of multikinase inhibitor	10
Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents	10
Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells	10
Correction: Hedyotis diffusae Herba-Andrographis Herba inhibits the cellular proliferation of nasopharyngeal carcinoma and triggers DNA damage through activation of p53 and p21	10
Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent m	10
Therapeutic targeting of the tryptophan-kynurenine-aryl hydrocarbon receptor pathway with apigenin in MED12-mutant leiomyoma cells	10
Editorial Expression of Concern: Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells	10
Atypical phosphatase DUSP11 inhibition promotes nc886 expression and potentiates gemcitabine-mediated cell death through NF-kB modulation	9
Retraction Note: circ_001504 promotes the development of renal cell carcinoma by sponging microRNA-149 to increase NUCB2	9
Unveiling mitochondrial and ribosomal gene deregulation and tumor microenvironment dynamics in acute myeloid leukemia	9
LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma	9
Correction: Synergistic tumor inhibition of colon cancer cells by nitazoxanide and obeticholic acid, a farnesoid X receptor ligand	9
GTF2E2 downregulated by miR-340-5p inhibits the malignant progression of glioblastoma	9
CILP is a potential pan-cancer marker: combined silico study and in vitro analyses	9
Methylstat sensitizes ovarian cancer cells to PARP-inhibition by targeting the histone demethylases JMJD1B/C	9
Correction to: ERCC6L that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating MAPK signalling pathw	9
Cleavage and polyadenylation machinery as a novel targetable vulnerability for human cancer	9
Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion	9
IGH repertoire analysis at scale: deciphering the complexity of B cell infiltration and migration in esophageal squamous cell carcinoma	9
Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy	9
Suicide gene strategies applied in ovarian cancer studies	9
Identification of a novel prognostic ADME-related signature associated with tumor immunity for aiding therapy in head and neck squamous cell carcinoma	9