OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Gene Therapy is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Reducing the risks of nuclear war—the role of health professionals	118
Correction to: Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis	116
Platelet activation: a barrier to effective antitumor immunity	104
Use of CRISPR-based screens to identify mechanisms of chemotherapy resistance	100
Small extracellular vesicle TGF-β in cancer progression and immune evasion	95
Defining treatment-resistant brain cancer: Genetic screening to identify oncogene-driven immunomodulation and therapy resistance	87
Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma	83
ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy	72
Adeno-associated virus-delivered alpha synuclein inhibits bladder cancer growth via the p53/p21 signaling pathway	71
P38 kinase in gastrointestinal cancers	63
Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X	60
Correction to: FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis	59
Ending nuclear weapons, before they end us	52
Pan-cancer oncogenic properties and therapeutic potential of SF3B4	52
Self-replicating messenger RNA based cancer immunotherapy	46
Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer	44
Role of non-coding RNAs in neuroblastoma	44
Expressed prognostic biomarkers for primary prostate cancer independent of multifocality and transcriptome heterogeneity	42
CircPKN2 promotes ferroptosis in bladder cancer by promoting the ubiquitination of Stearoyl-CoA Desaturase 1	41
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells	40
PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma	37
Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence	37
Unveiling the role of the extracellular matrix in the osteosarcoma tumor microenvironment through integrated transcriptomics and experimental validation	36
SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells	35
NRAV promotes HCC stemness via the m6A-regulated let-7c-5p/LIN28B axis	34

Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis	34
Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy	33
Exploring RNA biology in pseudomyxoma peritonei uncovers splicing dysregulation as a novel, targetable molecular vulnerability	30
Correction to: Lycium barbarum glycopeptide targets PER2 to inhibit lipogenesis in glioblastoma by downregulating SREBP1c	30
circXRCC5 foster gastric cancer growth and metastasis by the HNRNPC/circXRCC5/miR-655-3p/RREB1/UBA2 positive feedback loop	30
Aberrant DNA methylation impacts HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemia	30
Evaluation of the stability and intratumoral delivery of foreign transgenes encoded by an oncolytic Foamy Virus vector	29
CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages	29
BCL-xL dependency in chromophobe renal cell carcinoma	28
Real-world outcomes of Adjuvant De Gramont versus Xelox chemotherapy in reSected gasTric cancER: a propensity score-matched analysis (ASTER study)	28
Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent Glioblastoma	28
Targeted inactivation of EWSR1 : : FLI1 gene in Ewing sarcoma via CRISPR/Cas9 driven by an Ewing-specific GGAA promoter	26
Pathophysiological role of ion channels and transporters in HER2-positive breast cancer	26
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication	24
Bacillus Calmette-Guerin induces CD8+ T cell infiltration and suppresses tumor progression in microsatellite stable colorectal cancer by downregulating ARID1A	24
LncRNA CALML3-AS1 modulated by m6A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression	24
m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer	24
The target atlas for antibody-drug conjugates across solid cancers	24
Editorial Expression of Concern: p73β-expressing recombinant adenovirus: a potential anticancer agent	23
Editorial Expression of Concern: E1A-induced apoptosis does not prevent replication of adenoviruses with deletion of E1b in majority of infected cancer cells	22
Identification of HDAC4 as a potential therapeutic target and prognostic biomarker for ZFTA-fused ependymomas	22
Retraction Note: Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting	22
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma	21
Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway	21
Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification	20
CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process	20
NRF2-SOX4 complex regulates PSPH in hepatocellular carcinoma and modulates M2 macrophage differentiation	20
BETA prime: a first-in-man phase 1 study of AdAPT-001, an armed oncolytic adenovirus for solid tumors	20
m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1	20
Reversible downregulation of MYC in a spheroid model of metastatic epithelial ovarian cancer	19
Suppression of FOXO1 activity by SIRT1-mediated deacetylation weakening the intratumoral androgen autocrine function in glioblastoma	19
A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma	19
RETRACTED ARTICLE: Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting	19
Glimmers of hope for targeting oncogenic KRAS-G12D	19
Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway	19
A conditionally replicative adenovirus vector containing the synNotch receptor gene for the treatment of muscle-invasive bladder cancer	19
LOXL1-AS1 inhibits JAK2 ubiquitination and promotes cholangiocarcinoma progression through JAK2/STAT3 signaling	19
p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy	19
Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis	19
EZH1/2 as targets for cancer therapy	19
HIF-1α/IL-8 axis in hypoxic macrophages promotes esophageal cancer progression by enhancing PD-L1 expression	19
Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction	19
Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse	19
SMAD4-armed oncolytic adenovirus therapy potentiates the chemotherapy effects in NSCLC through suppression of the Wnt/β-catenin pathway	19
Chimeric Ad5/35 oncolytic adenovirus overcome preexisting neutralizing antibodies and enhance tumor targeting efficiency	19
IER3: exploring its dual function as an oncogene and tumor suppressor	18
Structural regulation of PLK1 activity: implications for cell cycle function and drug discovery	18
ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer	18
Hidden patterns of gene expression provide prognostic insight for colorectal cancer	17
METTL3 promotes the malignancy of non-small cell lung cancer by N6-methyladenosine modifying SFRP2	17

Extracellular vesicles released by glioma cells are decorated by Annexin A2 allowing for cellular uptake via heparan sulfate	17
Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer	17
Blocking tri-methylguanosine synthase 1 (TGS1) stops anchorage-independent growth of canine sarcomas	17
Knock-out of 5-lipoxygenase in overexpressing tumor cells—consequences on gene expression and cellular function	17
Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia	17
Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses	16
SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation	16
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice	16
WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer	16
Therapeutic potential of synthetic microRNA mimics based on the miR-15/107 consensus sequence	16
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma	16
NrCAM secreted by endometrial stromal cells enhances the progestin sensitivity of endometrial cancer cells through epigenetic modulation of PRB	16
CRISPR-Cas gene knockouts to optimize engineered T cells for cancer immunotherapy	16
CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR	16
Utilizing nullomers in cell-free RNA for early cancer detection	16
TFF3 sensitizes cervical carcinoma cells to cisplatin toxicity by binding to IGF2R	16
MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts	15
Correction to: Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway	15
An alternative fully human anti-BCMA CAR-T shows response for relapsed or refractory multiple myeloma with anti-BCMA CAR-T exposures previously	15
FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner	15
The long-term effectiveness and mechanism of oncolytic virotherapy combined with anti-PD-L1 antibody in colorectal cancer patient	15
Correction to: Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression	15
Correction: Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway	15
Global characterization of megakaryocytes in bone marrow, peripheral blood, and cord blood by single-cell RNA sequencing	15
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway	14
Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy	14
Gastrointestinal infections and gastrointestinal haemorrhage are underestimated but serious adverse events in chimeric antigen receptor T-cell recipients: A real-world study	14
MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response	14
RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma	14
STAT5a and SH2B3 novel mutations display malignancy roles in a triple-negative primary myelofibrosis patient	14
GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway	14
Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus	14
GPR107: A key driver of breast cancer invasion and metastasis through collagen IV modulation	14
Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens	13
Integration of humanized ROBO1 CAR in PD-1 locus in natural killer cells delivers synergistic tumor-killing effect against non-small cell lung cancer	13
Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells	13
A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer	13
Activating NRF2E79Q mutation alters the differentiation of human non-small cell lung cancer	13
A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation	13
TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling	13
Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines	13
Engineered L-asparaginase variants with enhanced therapeutic properties to improve treatment of childhood acute lymphatic leukemia	13
HPV status represents dominant trait driving delineation of survival-associated gene co-expression networks in head and neck cancer	13
Estrogen receptor status heterogeneity in breast cancer tumor: role in response to endocrine treatment	12
Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer	12
Editorial Expression of Concern: Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells	12
Oleuropein regulates ubiquitination-mediated Mcl-1 turnover and exhibits antitumor activity	12
Somatic copy number alteration predicts clinical benefit of lung adenocarcinoma patients treated with cytokine-induced killer plus chemotherapy	12
Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma	12
Therapeutic targeting of the tryptophan-kynurenine-aryl hydrocarbon receptor pathway with apigenin in MED12-mutant leiomyoma cells	12
Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model	12
Microbiota in tumors: new factor influencing cancer development	12
Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition	12
Correction: Hedyotis diffusae Herba-Andrographis Herba inhibits the cellular proliferation of nasopharyngeal carcinoma and triggers DNA damage through activation of p53 and p21	12
GAS5 attenuates the malignant progression of glioma stem-like cells by promoting E-cadherin	12
Retraction Note: microRNA-133a exerts tumor suppressive role in oral squamous cell carcinoma through the Notch signaling pathway via downregulation of CTBP2	12
m6A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis	11
Correction to: ERCC6L that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating MAPK signalling pathw	11
Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy	11
RUNX1A isoform is overexpressed in acute myeloid leukemia and is associated with FLT3 internal tandem duplications	11
Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion	11
Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative colitis-associated colorectal cancer and MMP1 as a potential therapeutic target	11
Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents	11
GTF2E2 downregulated by miR-340-5p inhibits the malignant progression of glioblastoma	11
Long non-coding RNAs and signaling networks in non-small cell lung cancer: mechanistic insights into tumor pathogenesis	11
The dual role of GPX4 in breast cancer: mechanisms of therapeutic resistance and potential for novel targeted therapies	11
Identification of a novel prognostic ADME-related signature associated with tumor immunity for aiding therapy in head and neck squamous cell carcinoma	11
New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene	11
Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent m	11
Olfactomedin 4 produces dysplasia but suppresses metastasis of colon cancer	11
Anti-leukemia effects of omipalisib in acute myeloid leukemia: inhibition of PI3K/AKT/mTOR signaling and suppression of mitochondrial biogenesis	11
Atypical phosphatase DUSP11 inhibition promotes nc886 expression and potentiates gemcitabine-mediated cell death through NF-kB modulation	11
Cleavage and polyadenylation machinery as a novel targetable vulnerability for human cancer	11
Suicide gene strategies applied in ovarian cancer studies	11