Cancer Gene Therapy

Papers
(The TQCC of Cancer Gene Therapy is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
ArticleCitations
Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms433
Key chemokines direct migration of immune cells in solid tumors186
Cancer-associated fibroblasts: overview, progress, challenges, and directions156
Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death129
METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway98
TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials89
The KRAS-G12C inhibitor: activity and resistance64
ESCRT-III-mediated membrane repair in cell death and tumor resistance53
LOX-1 and cancer: an indissoluble liaison50
Use of CAR T-cell for acute lymphoblastic leukemia (ALL) treatment: a review study50
HDAC3-dependent transcriptional repression of FOXA2 regulates FTO/m6A/MYC signaling to contribute to the development of gastric cancer50
Nanomedicine-based cancer immunotherapy: recent trends and future perspectives45
Roles of miRNA dysregulation in the pathogenesis of multiple myeloma40
Autophagy and gastrointestinal cancers: the behind the scenes role of long non-coding RNAs in initiation, progression, and treatment resistance38
Expression pattern of m6A regulators is significantly correlated with malignancy and antitumor immune response of breast cancer38
Hsa_circRNA_102002 facilitates metastasis of papillary thyroid cancer through regulating miR-488-3p/HAS2 axis38
Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy36
CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model35
Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy34
Oncolytic adenoviruses synergistically enhance anti-PD-L1 and anti-CTLA-4 immunotherapy by modulating the tumour microenvironment in a 4T1 orthotopic mouse model33
Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma33
TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential33
Extracellular vesicles-encapsulated microRNA-10a-5p shed from cancer-associated fibroblast facilitates cervical squamous cell carcinoma cell angiogenesis and tumorigenicity via Hedgehog signaling path29
GINS2 promotes EMT in pancreatic cancer via specifically stimulating ERK/MAPK signaling28
LncRNA LINC01857 promotes cell growth and diminishes apoptosis via PI3K/mTOR pathway and EMT process by regulating miR-141-3p/MAP4K4 axis in diffuse large B-cell lymphoma28
Cytokine-enhanced cytolytic activity of exosomes from NK Cells27
Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD4027
Chimeric Antigen Receptor-modified T cells targeting EphA2 for the immunotherapy of paediatric bone tumours26
Oncolytic virus promotes tumor-reactive infiltrating lymphocytes for adoptive cell therapy26
LncRNA KCNQ1OT1 facilitates the progression of bladder cancer by targeting MiR-218-5p/HS3ST3B125
The V-ATPases in cancer and cell death25
circSFMBT1 promotes pancreatic cancer growth and metastasis via targeting miR-330-5p/PAK1 axis25
MicroRNA-375 represses tumor angiogenesis and reverses resistance to sorafenib in hepatocarcinoma24
Recent updates on chimeric antigen receptor T cell therapy for hepatocellular carcinoma23
Protein post-translational modifications in the regulation of cancer hallmarks23
Anti-SSTR2 antibody-drug conjugate for neuroendocrine tumor therapy23
YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer22
Elevating microRNA-1-3p shuttled by cancer-associated fibroblasts-derived extracellular vesicles suppresses breast cancer progression and metastasis by inhibiting GLIS122
LncRNA HLA-F-AS1 promotes colorectal cancer metastasis by inducing PFN1 in colorectal cancer-derived extracellular vesicles and mediating macrophage polarization22
Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness22
The changing face of gastric cancer: epidemiologic trends and advances in novel therapies21
LncRNAs in breast cancer: a link to future approaches21
EPHA5 mutation predicts the durable clinical benefit of immune checkpoint inhibitors in patients with lung adenocarcinoma21
Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis21
Regulation of DNA methylation machinery by epi-miRNAs in human cancer: emerging new targets in cancer therapy21
PRMT5: a putative oncogene and therapeutic target in prostate cancer21
LincRNA-ROR is activated by H3K27 acetylation and induces EMT in retinoblastoma by acting as a sponge of miR-32 to activate the Notch signaling pathway21
Delivery technologies to engineer natural killer cells for cancer immunotherapy20
FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis20
circRACGAP1 promotes non-small cell lung cancer proliferation by regulating miR-144-5p/CDKL1 signaling pathway20
LncRNA UCA1 promotes SOX12 expression in breast cancer by regulating m6A modification of miR-375 by METTL14 through DNA methylation19
Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway19
Upregulated lncRNA DLX6-AS1 underpins hepatocellular carcinoma progression via the miR-513c/Cul4A/ANXA10 axis19
Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation19
SNHG17/miR-384/ELF1 axis promotes cell growth by transcriptional regulation of CTNNB1 to activate Wnt/β-catenin pathway in oral squamous cell carcinoma18
Vector engineering, strategies and targets in cancer gene therapy18
Overcoming target epitope masking resistance that can occur on low-antigen-expresser AML blasts after IL-1RAP chimeric antigen receptor T cell therapy using the inducible caspase 9 suicide gene safety18
Genetically engineered mesenchymal stem cells: targeted delivery of immunomodulatory agents for tumor eradication18
RHPN1-AS1 promotes cell proliferation and migration via miR-665/Akt3 in ovarian cancer17
Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia-inducible factor-1α (HIF-1α) in support of spermatogenesis and tumorigenesis17
An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway17
Synergistic tumor inhibition of colon cancer cells by nitazoxanide and obeticholic acid, a farnesoid X receptor ligand17
Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma17
Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules17
LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma16
Recent advances in immune therapies for gastric cancer16
Apatinib prevents natural killer cell dysfunction to enhance the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma16
microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner15
BATF3 promotes malignant phenotype of colorectal cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 axis15
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas15
LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF115
Long non-coding RNA LINC02446 suppresses the proliferation and metastasis of bladder cancer cells by binding with EIF3G and regulating the mTOR signalling pathway15
SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells15
Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes15
SMURF1, a promoter of tumor cell progression?15
Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling15
Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy15
Circular RNA hsa_circ_0009172 suppresses gastric cancer by regulation of microRNA-485-3p-mediated NTRK314
Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells14
LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression14
METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression14
m6A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis14
Clinical trials of self-replicating RNA-based cancer vaccines14
LncRNA KCNQ1OT1 regulates the invasion and migration of hepatocellular carcinoma by acting on S1PR1 through miR-14914
LncRNA SNHG5 promotes the proliferation and cancer stem cell-like properties of HCC by regulating UPF1 and Wnt-signaling pathway14
Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A114
miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer13
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN113
Decellularized normal and cancer tissues as tools for cancer research13
Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma13
Proof of principle study of sequential combination atezolizumab and Vigil in relapsed ovarian cancer13
m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer13
CircRNA circ_0006156 inhibits the metastasis of prostate cancer by blocking the ubiquitination of S100A913
Viroimmunotherapy for breast cancer: promises, problems and future directions13
Downregulation of SBF2-AS1 functions as a tumor suppressor in clear cell renal cell carcinoma by inhibiting miR-338-3p-targeted ETS113
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway12
A new immunotherapy strategy targeted CD30 in peripheral T-cell lymphomas: CAR-modified T-cell therapy based on CD30 mAb12
c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 112
RETRACTED ARTICLE: circ_001504 promotes the development of renal cell carcinoma by sponging microRNA-149 to increase NUCB212
Cannabinoids orchestrate cross-talk between cancer cells and endothelial cells in colorectal cancer12
Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment12
Safety of Adeno-associated virus-based vector-mediated gene therapy—impact of vector dose12
NEAT1 in bone marrow mesenchymal stem cell-derived extracellular vesicles promotes melanoma by inducing M2 macrophage polarization12
YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma12
Silencing long noncoding RNA colon cancer-associated transcript-1 upregulates microRNA-34a-5p to promote proliferation and differentiation of osteoblasts in osteoporosis12
Tumor suppressor immune gene therapy to reverse immunotherapy resistance12
Recent progress in exosome research: isolation, characterization and clinical applications12
Mechanisms of drug resistance mediated by long non-coding RNAs in non-small-cell lung cancer12
Enhanced antitumor immune response in melanoma tumor model by anti-PD-1 small interference RNA encapsulated in nanoliposomes12
Long-term response to autologous anti-CD19 chimeric antigen receptor T cells in relapsed or refractory B cell acute lymphoblastic leukemia: a systematic review and meta-analysis12
LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway11
MicroRNA-766-3p-mediated downregulation of HNF4G inhibits proliferation in colorectal cancer cells through the PI3K/AKT pathway11
Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model11
Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin11
EZH1/2 as targets for cancer therapy11
Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer11
UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P5311
DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP11
Downregulation of miR-335 exhibited an oncogenic effect via promoting KDM3A/YAP1 networks in clear cell renal cell carcinoma11
Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling11
Human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p inhibits progression of human endometrial cancer cells through downregulating MEST11
LSD1-mediated stabilization of SEPT6 protein activates the TGF-β1 pathway and regulates non-small-cell lung cancer metastasis10
CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy10
RETRACTED ARTICLE: microRNA-211-mediated targeting of the INHBA-TGF-β axis suppresses prostate tumor formation and growth10
ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis10
Molecular mechanism of miR-34b-5p and RNA binding protein HuR binding to lncRNA OIP5-AS1 in colon cancer cells10
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway10
CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells10
microRNA-9-5p regulates the mitochondrial function of hepatocellular carcinoma cells through suppressing PDK410
The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs10
The LIN28B/TGF-β/TGFBI feedback loop promotes cell migration and tumour initiation potential in cholangiocarcinoma10
Long non-coding RNA FOXD3-AS1 silencing exerts tumor suppressive effects in nasopharyngeal carcinoma by downregulating FOXD3 expression via microRNA-185-3p upregulation10
New targeted and epigenetic therapeutic strategies for the treatment of uveal melanoma10
Cancer immunotherapies revisited: state of the art of conventional treatments and next-generation nanomedicines10
Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis9
RETRACTED ARTICLE: Silencing of long non-coding RNA XIST represses gastric cancer progression through blocking NFκB pathway via inhibiting HNF4A-mediated transcription of EPHA19
CDK4/6-USP51 axis regulates lung adenocarcinoma metastasis through ZEB19
Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice9
Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse9
Bone marrow stromal cells-derived microRNA-181-containing extracellular vesicles inhibit ovarian cancer cell chemoresistance by downregulating MEST via the Wnt/β-catenin signaling pathway9
Intratumoral DNA-based delivery of checkpoint-inhibiting antibodies and interleukin 12 triggers T cell infiltration and anti-tumor response9
Genomic alterations caused by HPV integration in a cohort of Chinese endocervical adenocarcinomas9
Whole-exome sequencing in eccrine porocarcinoma indicates promising therapeutic strategies9
Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours9
Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways9
The application of CRISPR/Cas9 system in cervical carcinogenesis9
Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer9
LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells9
Flotillin-1 palmitoylation turnover by APT-1 and ZDHHC-19 promotes cervical cancer progression by suppressing IGF-1 receptor desensitization and proteostasis9
Correction: Cancer-associated fibroblasts: overview, progress, challenges, and directions9
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