OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Gene Therapy is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Key chemokines direct migration of immune cells in solid tumors	237
Cancer-associated fibroblasts: overview, progress, challenges, and directions	183
The KRAS-G12C inhibitor: activity and resistance	89
Use of CAR T-cell for acute lymphoblastic leukemia (ALL) treatment: a review study	73
LOX-1 and cancer: an indissoluble liaison	65
Nanomedicine-based cancer immunotherapy: recent trends and future perspectives	53
Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy	49
CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model	46
Protein post-translational modifications in the regulation of cancer hallmarks	46
Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy	45
The V-ATPases in cancer and cell death	44
Roles of miRNA dysregulation in the pathogenesis of multiple myeloma	42
Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma	41
Autophagy and gastrointestinal cancers: the behind the scenes role of long non-coding RNAs in initiation, progression, and treatment resistance	41
Oncolytic adenoviruses synergistically enhance anti-PD-L1 and anti-CTLA-4 immunotherapy by modulating the tumour microenvironment in a 4T1 orthotopic mouse model	40
TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential	38
Extracellular vesicles-encapsulated microRNA-10a-5p shed from cancer-associated fibroblast facilitates cervical squamous cell carcinoma cell angiogenesis and tumorigenicity via Hedgehog signaling path	34
Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy	31
Recent updates on chimeric antigen receptor T cell therapy for hepatocellular carcinoma	30
LncRNAs in breast cancer: a link to future approaches	30
LncRNA LINC01857 promotes cell growth and diminishes apoptosis via PI3K/mTOR pathway and EMT process by regulating miR-141-3p/MAP4K4 axis in diffuse large B-cell lymphoma	30
Cytokine-enhanced cytolytic activity of exosomes from NK Cells	30
Elevating microRNA-1-3p shuttled by cancer-associated fibroblasts-derived extracellular vesicles suppresses breast cancer progression and metastasis by inhibiting GLIS1	29
Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness	28
Recent progress in exosome research: isolation, characterization and clinical applications	28

Delivery technologies to engineer natural killer cells for cancer immunotherapy	28
LncRNA SNHG5 promotes the proliferation and cancer stem cell-like properties of HCC by regulating UPF1 and Wnt-signaling pathway	27
PRMT5: a putative oncogene and therapeutic target in prostate cancer	26
Vector engineering, strategies and targets in cancer gene therapy	26
LncRNA HLA-F-AS1 promotes colorectal cancer metastasis by inducing PFN1 in colorectal cancer-derived extracellular vesicles and mediating macrophage polarization	26
YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer	24
Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway	24
Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma	24
Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis	23
Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation	22
Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling	22
Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia-inducible factor-1α (HIF-1α) in support of spermatogenesis and tumorigenesis	22
m6A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis	21
LncRNA UCA1 promotes SOX12 expression in breast cancer by regulating m6A modification of miR-375 by METTL14 through DNA methylation	21
Clinical trials of self-replicating RNA-based cancer vaccines	21
FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis	21
Decellularized normal and cancer tissues as tools for cancer research	20
SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells	20
SNHG17/miR-384/ELF1 axis promotes cell growth by transcriptional regulation of CTNNB1 to activate Wnt/β-catenin pathway in oral squamous cell carcinoma	20
Proof of principle study of sequential combination atezolizumab and Vigil in relapsed ovarian cancer	20
Upregulated lncRNA DLX6-AS1 underpins hepatocellular carcinoma progression via the miR-513c/Cul4A/ANXA10 axis	20
Overcoming target epitope masking resistance that can occur on low-antigen-expresser AML blasts after IL-1RAP chimeric antigen receptor T cell therapy using the inducible caspase 9 suicide gene safety	20
LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma	20
LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression	20
Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules	19
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas	19
LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells	19
Long-term response to autologous anti-CD19 chimeric antigen receptor T cells in relapsed or refractory B cell acute lymphoblastic leukemia: a systematic review and meta-analysis	19
SMURF1, a promoter of tumor cell progression?	18
microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner	18
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway	18
Extracellular vesicles released by glioma cells are decorated by Annexin A2 allowing for cellular uptake via heparan sulfate	18
CAR T therapies in multiple myeloma: unleashing the future	17
Recent advances in immune therapies for gastric cancer	17
Tumor suppressor immune gene therapy to reverse immunotherapy resistance	17
Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis	16
Long non-coding RNA LINC02446 suppresses the proliferation and metastasis of bladder cancer cells by binding with EIF3G and regulating the mTOR signalling pathway	16
Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells	16
CircRNA circ_0006156 inhibits the metastasis of prostate cancer by blocking the ubiquitination of S100A9	16
LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF1	16
Safety of Adeno-associated virus-based vector-mediated gene therapy—impact of vector dose	16
m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer	16
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1	16
Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma	16
Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer	16
Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling	16
Viroimmunotherapy for breast cancer: promises, problems and future directions	15
EZH1/2 as targets for cancer therapy	15
METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression	15
YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma	15

Circular RNA hsa_circ_0009172 suppresses gastric cancer by regulation of microRNA-485-3p-mediated NTRK3	15
LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway	14
Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424-5p/SOX9 axis through PI3K/AKT pathway	14
Streptococcal bacterial components in cancer therapy	14
Cannabinoids orchestrate cross-talk between cancer cells and endothelial cells in colorectal cancer	14
c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1	14
Next generation self-replicating RNA vectors for vaccines and immunotherapies	14
The application of CRISPR/Cas9 system in cervical carcinogenesis	13
A new immunotherapy strategy targeted CD30 in peripheral T-cell lymphomas: CAR-modified T-cell therapy based on CD30 mAb	13
Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways	13
Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment	13
Enhanced antitumor immune response in melanoma tumor model by anti-PD-1 small interference RNA encapsulated in nanoliposomes	13
Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1	13
Downregulation of miR-335 exhibited an oncogenic effect via promoting KDM3A/YAP1 networks in clear cell renal cell carcinoma	13
Human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p inhibits progression of human endometrial cancer cells through downregulating MEST	13
Silencing long noncoding RNA colon cancer-associated transcript-1 upregulates microRNA-34a-5p to promote proliferation and differentiation of osteoblasts in osteoporosis	13
Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours	12
DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP	12
The LIN28B/TGF-β/TGFBI feedback loop promotes cell migration and tumour initiation potential in cholangiocarcinoma	12
LSD1-mediated stabilization of SEPT6 protein activates the TGF-β1 pathway and regulates non-small-cell lung cancer metastasis	12
New targeted and epigenetic therapeutic strategies for the treatment of uveal melanoma	12
Cancer immunotherapies revisited: state of the art of conventional treatments and next-generation nanomedicines	12
Targeting GNAQ/11 through PKC inhibition in uveal melanoma	12
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma	12
MicroRNA-766-3p-mediated downregulation of HNF4G inhibits proliferation in colorectal cancer cells through the PI3K/AKT pathway	12
Whole-exome sequencing in eccrine porocarcinoma indicates promising therapeutic strategies	12
Flotillin-1 palmitoylation turnover by APT-1 and ZDHHC-19 promotes cervical cancer progression by suppressing IGF-1 receptor desensitization and proteostasis	12
Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin	12
Intratumoral DNA-based delivery of checkpoint-inhibiting antibodies and interleukin 12 triggers T cell infiltration and anti-tumor response	12
CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy	12
NEAT1 in bone marrow mesenchymal stem cell-derived extracellular vesicles promotes melanoma by inducing M2 macrophage polarization	12
Molecular mechanism of miR-34b-5p and RNA binding protein HuR binding to lncRNA OIP5-AS1 in colon cancer cells	11
LncNAP1L6 activates MMP pathway by stabilizing the m6A-modified NAP1L2 to promote malignant progression in prostate cancer	11
Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting	11
CDK4/6-USP51 axis regulates lung adenocarcinoma metastasis through ZEB1	11
Non-classical Notch signaling by MDA-MB-231 breast cancer cell-derived small extracellular vesicles promotes malignancy in poorly invasive MCF-7 cells	11
Long non-coding RNA FOXD3-AS1 silencing exerts tumor suppressive effects in nasopharyngeal carcinoma by downregulating FOXD3 expression via microRNA-185-3p upregulation	11
Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells	11
CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells	10
Inhibition of myeloid PD-L1 suppresses osteoclastogenesis and cancer bone metastasis	10
LncRNA-NEF suppressed oxaliplatin resistance and epithelial-mesenchymal transition in colorectal cancer through epigenetically inactivating MEK/ERK signaling	10
Global characterization of megakaryocytes in bone marrow, peripheral blood, and cord blood by single-cell RNA sequencing	10
Correction: Cancer-associated fibroblasts: overview, progress, challenges, and directions	10
TAF1A and ZBTB41 serve as novel key genes in cervical cancer identified by integrated approaches	10
Lycium barbarum glycopeptide targets PER2 to inhibit lipogenesis in glioblastoma by downregulating SREBP1c	10
Regulation of tumor metabolism by post translational modifications on metabolic enzymes	10
RETRACTED ARTICLE: microRNA-211-mediated targeting of the INHBA-TGF-β axis suppresses prostate tumor formation and growth	10
Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia	10
RETRACTED ARTICLE: Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9	10
The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs	10
P38 kinase in gastrointestinal cancers	10
FUT6 inhibits the proliferation, migration, invasion, and EGF-induced EMT of head and neck squamous cell carcinoma (HNSCC) by regulating EGFR/ERK/STAT signaling pathway	10
Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses	10
ERRα coordinates actin and focal adhesion dynamics	10
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway	10
Genomic alterations caused by HPV integration in a cohort of Chinese endocervical adenocarcinomas	10
microRNA-9-5p regulates the mitochondrial function of hepatocellular carcinoma cells through suppressing PDK4	10
Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model	10
Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse	10
NCBP2 and TFRC are novel prognostic biomarkers in oral squamous cell carcinoma	10
Exosomal HMGA2 protein from EBV-positive NPC cells destroys vascular endothelial barriers and induces endothelial-to-mesenchymal transition to promote metastasis	10
Cancer vaccine strategies using self-replicating RNA viral platforms	10
Recent progress of CDK4/6 inhibitors’ current practice in breast cancer	10
HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor	9
RETRACTED ARTICLE: Silencing of long non-coding RNA XIST represses gastric cancer progression through blocking NFκB pathway via inhibiting HNF4A-mediated transcription of EPHA1	9
Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis	9
RETRACTED ARTICLE: CREB3L4 promotes angiogenesis and tumor progression in gastric cancer through regulating VEGFA expression	9
Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT	9
MiR-181c sensitizes ovarian cancer cells to paclitaxel by targeting GRP78 through the PI3K/Akt pathway	9
Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway	9
Overexpression of microRNA-130a represses uveal melanoma cell migration and invasion through inactivation of the Wnt/β-catenin signaling pathway by downregulating USP6	9
Targeting CLK4 inhibits the metastasis and progression of breast cancer by inactivating TGF-β pathway	9
Combination regimen of granulocyte colony-stimulating factor and recombinant human thrombopoietin improves the curative effect on elderly patients with leukemia through inducing pyroptosis and ferropt	9
circPTPN22 attenuates immune microenvironment of pancreatic cancer via STAT3 acetylation	9
E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA	9
Long noncoding RNA LINC01291 promotes the aggressive properties of melanoma by functioning as a competing endogenous RNA for microRNA-625-5p and subsequently increasing IGF-1R expression	9
Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X	9