Biological & Pharmaceutical Bulletin

Article	Citations
Disproportionality Analysis of Safety Signals for a Wide Variety of Opioid-Related Adverse Events in Elderly Patients Using the Japanese Adverse Drug Event Report (JADER) Database	41
Chlorogenic Acid Inhibited Epithelial–Mesenchymal Transition to Treat Pulmonary Fibrosis through Modulating Autophagy	40
Changes in Pharmacy Students’ Awareness of Hepatitis B Patients through Patient Lectures as Humanity Education: Findings from Questionnaire Surveys of Face-to-Face and Simultaneous Remote Classes	30
New Directions for Advanced Targeting Strategies of EGFR Signaling in Cancer	27
Genipin Attenuates Sepsis-Induced Splenocyte Apoptosis <i>via</i> the Inhibition of Endoplasmic Reticulum Stress	27
Protective Effect of Pemafibrate Treatment against Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats	27
Russelioside A, a Pregnane Glycoside from <i>Caralluma tuberculate</i>, Inhibits Cell-Intrinsic NF-κB Activity and Metastatic Ability of Breast Cancer Cells	27
Errata for Biological and Pharmaceutical Bulletin	25
Prediction of the Area under the Curve Using Limited-Point Blood Sampling in a Cocktail Study to Assess Multiple CYP Activities	23
Dietary Zinc Deficiency Induces Ca<sub>v</sub>3.2-Dependent Nociceptive Hypersensitivity in Mice	21
Intestinal Absorption of Alogliptin Is Mediated by a Fruit-Juice-Sensitive Transporter	21
Effects of Disodium Cromoglycate Treatment in the Early Stage of Diabetic Nephropathy: Focus on Collagen Deposition	21
Effect of Amino Acid Substitution on Cell Adhesion Properties of Octa-arginine	21
Effect of Chronic Ethanol Consumption on Exogenous Glucose Metabolism in Rats Using [1-<sup>13</sup>C], [2-<sup>13</sup>C], and [3-<sup>13</sup>C]glucose Breath Tes	20
Characterization of Potentially Inappropriate Medications That Need Special Attention in the Elderly with Dementia by Analyzing Pharmacy Claims Data	20
Association between Weight Gain and Sex-Related Differences through 5-Fluorouracil Administration	20
Clinical Consumption of Compound Opioid Analgesics in China: A Retrospective Analysis of National Data 2015–2018	19
Novel Screening System for Biliary Excretion of Drugs Using Human Cholangiocyte Organoid Monolayers with Directional Drug Transport	19
Reduced Relaxant Response to Adenine in the Superior Mesenteric Artery of Spontaneously Hypertensive Rats	18
Comprehensive Exploration of Medications That Affect the Bleeding Risk of Oral Anticoagulant Users	18
Vitamin K3 Suppresses Pyroptosis in THP-1 Cells through Inhibition of NF-κB and JNK Signaling Pathways	18
Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database	17
Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma	17
Cross-Cancer Type Evaluation of Potential Interstitial Lung Disease Complications of Immune Checkpoint Inhibitors Using JADER	16
Assessment of Adherence to Post-exposure Prophylaxis with Oseltamivir in Healthcare Workers: A Retrospective Questionnaire-Based Study	16

Target Therapeutic Ranges of Anti-MRSA Drugs, Linezolid, Tedizolid and Daptomycin, and the Necessity of TDM	15
Development of an Analytical Method for Unsaturated Disaccharides from Heparan Sulfate Using Dansylhydrazine Derivatization and High-Performance Liquid Chromatography with Fluorescence Detection	14
A Novel Function of Sphingosylphosphorylcholine on the Inhibitory Effects of Acetylcholinesterase Activity	14
Macrophage Response Driven by Extracellular ATP	14
Sorghum (<i>Sorghum bicolor</i>) Extract-Induced Adipogenesis Is Independent of PPARγ Ser273 Phosphorylation in 3T3-L1 Adipocytes	14
Comparison of Addition of Indications for Antineoplastic Agents Approved in the United States and Japan from 2001 to 2020	14
Selective Inhibitory Effect of Hesperetin on the Automaticity of the Guinea Pig Pulmonary Vein Myocardium	13
The Role of SGLT2 Inhibitor Ipragliflozin on Cardiac Hypertrophy and microRNA Expression Profiles in a Non-diabetic Rat Model of Cardiomyopathy	13
Effect of Celecoxib Administration on the Skin of 40-Week-Old Mice	13
Lymphatic Transport and Immune Activation Effect by Locally Administered Extracellular Vesicles from <i>Saccharomyces cerevisiae</i> as Biocompatible Vaccine Adjuvants	13
Chronic Treatment with Aβ42 with a Toxic Conformer and LPS Induces Inflammatory Responses in BV-2 Microglia with Dysregulation of Hypoxia-Inducible Factor Expression	13
Process Optimization of Charge-Reversible Lipid Nanoparticles for Cytosolic Protein Delivery Using the Design-of-Experiment Approach	13
Vascular Leakage Prevention by Roundabout 4 under Pathological Conditions	13
Impact of Drugs and Patient Characteristics on Life Expectancy during the Induction Phase of Dialysis	12
Lipopolysaccharide Priming Exacerbates Anaphylatoxin C5a-Induced Anaphylaxis in Mice	12
3-Nitropropionic Acid Enhances Ferroptotic Cell Death <i>via</i> NOX2-Mediated ROS Generation in STHdhQ111 Striatal Cells Carrying Mutant Huntingtin	12
Amodiaquine Analogs Are Potent Inhibitors of Interleukin-6 Production Induced by Activation of Toll-Like Receptors Recognizing Pathogen Nucleic Acids	12
Shimanami Leaf Intake Affects Bowel Movement and Intestinal Microbiota in Mice	12
Population Pharmacokinetic Model of Amiodarone and <i>N</i>-Desethylamiodarone Focusing on Glucocorticoid and Inflammation	12
Magnitude of Fruit Juice–Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices	12
LncRNA <i>Gm16638-201</i> Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors	12
RasGRP2 Attenuates TAGE Modification of eNOS in Vascular Endothelial Cells	12
Indomethacin, a Non-steroidal Anti-inflammatory Drug, Induces Skin Dryness <i>via</i> PPARγ in Mice	12
Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner	12
3′,4′-Dihydroxyflavonol Attenuates Lipopolysaccharide-Induced Neuroinflammatory Responses of Microglial Cells by Suppressing AKT–mTOR and NF-κB Pathways	11
Inhibition of p38 Mitogen-Activated Protein Kinases Attenuates Methylmercury Toxicity in SH-SY5Y Neuroblastoma Cells	11
Dosing Optimization of Ampicillin-Sulbactam Based on Cystatin C in Elderly Patients with Pneumonia	11
Piperacillin Exacerbates Vancomycin-Induced Toxicity in Renal Proximal Tubular Cells	11
A Reactive Metabolite of Clozapine Induces Hematopoietic Toxicity in HL-60 Cells Undergoing Granulocytic Differentiation through Its Effect on Glutathione Metabolism	11
Usefulness of an Intermittently Scanned Continuous Glucose Monitoring System for Risk Management of Individuals without Diabetes in Japan	11
Inhibition Mechanism of SARS-CoV-2 Infection by a Cholesterol Derivative, Nat-20(S)-yne	11
Exploring Cell-Penetrating Peptides as Penetration Enhancers in Eye Drop Formulations Using a Reconstructed Human Corneal Epithelial Model	11
Pharmacological Investigation of Hypoalbuminemia on the Prolonged and Potentiated Action of Midazolam in Rats	11
Kuanoniamine C Suppresses Adipogenesis and White Adipose Tissue Expansion by Modulating Mitochondrial Function	11
Fosphenytoin Alleviates Herpes Simplex Virus Infection-Induced Provoked and Spontaneous Pain-Like Behaviors in Mice	11
Structural Perspective of the Double-Stranded RNA Transport Mechanism by SID-1 Family Proteins	11
Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates	11
Effects of Antibacterial Agents on Cancerous Cell Proliferation	10
Detoxification and Activating Blood Circulation Decoction Promotes Reendothelialization of Damaged Blood Vessels <i>via</i> VEGF Signaling Pathway Activation by miRNA-126	10
Tapentadol in Cancer Patients with Neuropathic Pain: A Comparison of Methadone, Oxycodone, Fentanyl, and Hydromorphone	10
Nrf2 Expression Is Decreased in LRRK2 Transgenic Mouse Brain and LRRK2 Overexpressing SH-SY5Y Cells	10
Effect of a Single Dose of Oxaliplatin on the Induction of Peripheral Neuropathy in a Rat Model: An <i>in Vivo</i> Electrophysiological Study	10
Perineural Treatment with High Mobility Group Box-1 Monoclonal Antibody Prevents Initiation of Pain-Like Behaviors in Female Mice with Trigeminal Neuropathy	10
L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α<sub>1B</sub> Receptor at the Second Transmembrane Interface	10
ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia	10
Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway	10
Innovative System for Delivering Nucleic Acids/Genes Based on Controlled Intracellular Trafficking as Well as Controlled Biodistribution for Nanomedicines	10
Intracerebroventricular Administration of Dermorphin-Dynorphin Analogs Producing Antidepressant-Like Effects through Activation of μ<sub>1</sub>- and κ-Opioid Receptors in Mice	10
Dose Individualization of Oral Multi-Kinase Inhibitors for the Implementation of Therapeutic Drug Monitoring	10
Structure and Immunomodulatory Activity of Glycogen Derived from Honeybee Larvae (<i>Apis mellifera</i>)	10

Cloperastine Reduces IL-6 Expression <i>via</i> Akt/GSK3/Nrf2 Signaling in Monocytes/Macrophages and Ameliorates Symptoms in a Mouse Sepsis Model Induced by Lipopolysaccharide	9
Calcium Peroxide-Containing Polydimethylsiloxane-Based Microwells for Inhibiting Cell Death in Spheroids through Improved Oxygen Supply	9
Dictamnine Ameliorates DNFB-Induced Atopic Dermatitis Like Skin Lesions in Mice by Inhibiting M1 Macrophage Polarization and Promoting Autophagy	9
Platelets Affect the Activity of Amino Acid Transporter SNAT4 in HuH-7 Human Hepatoma Cells	9
Foreword	9
Clinical Analysis and <i>in Vitro</i> Correlation of BCRP-Mediated Drug–Drug Interaction in the Gastrointestinal Tract	9
Phosphatidylcholine-Plasmalogen-Oleic Acid Has Protective Effects against Arachidonic Acid-Induced Cytotoxicity	9
Impact of Cilostazol Pharmacokinetics on the Development of Cardiovascular Side Effects in Patients with Cerebral Infarction	9
Antidepressant Effect of Intracerebroventricularly Administered Deltorphin Analogs in the Mouse Tail Suspension Test	9
Incorrect Holding Angle of Dry Powder Inhaler during the Drug-Loading Step Significantly Decreases Output Efficiency	9
Andrographolide/Phospholipid/Cyclodextrin Complex-Loaded Nanoemulsion: Preparation, Optimization, <i>in Vitro</i> and <i>in Vivo</i> Evaluation	9
Chronotropic and Inotropic Effects of Sudachitin, a Polymethoxyflavone from the Peel of <i>Citrus sudachi</i> on Isolated Rat Atria and Its Underlying Mechanisms	9
Carbon Monoxide Alleviates Post-ischemia–reperfusion Skeletal Muscle Injury and Systemic Inflammation	8
Substrate-Dependent Alteration in the <i>C</i>- and <i>O</i>-Prenylation Specificities of <i>Cannabis</i> Prenyltransferase	8
Infliximab Treatment Persistence among Japanese Patients with Chronic Inflammatory Diseases: A Retrospective Japanese Claims Data Study	8
Methylselenocysteine Potentiates Etoposide-Induced Cytotoxicity by Enhancing Gap Junction Activity	8
Panobinostat, a Histone Deacetylase Inhibitor, Reduces LPS-Induced Expression of Inducible Nitric Oxide Synthase in Rat Immortalized Microglia HAPI Cells	8
Siweixizangmaoru Decoction Ameliorated Type II Collagen-Induced Arthritis in Rats <i>via</i> Regulating JAK2–STAT3 and NF-κB Signaling Pathway	8
Signal Detection of Potential Hepatotoxic Drugs: Case-Control Study Using Both a Spontaneous Reporting System and Electronic Medical Records	8
The Cyclin-Dependent Kinase 4/6 Inhibitor Abemaciclib Is Tolerated Better than Palbociclib by Advanced Breast Cancer Patients with High Serum Albumin Levels	8
Influence of the Th1 Cytokine Environment on CCL5 Production from Langerhans Cells	8
Ginsenosides in <i>Panax ginseng</i> Extract Promote Anagen Transition by Suppressing BMP4 Expression and Promote Human Hair Growth by Stimulating Follicle-Cell Proliferation	8
Effect of Orally Ingested Water Containing H<sub>2</sub>-Filled Ultrafine Bubbles (UFBs) on Ethanol-Induced Oxidative Stress in Rats	8
A Novel Cross-Immune Antigen Vaccine Platform for Influenza Virus Type A	8
Downregulation of Genes for Skeletal Muscle Extracellular Matrix Components by Cisplatin	8
Ononin Relieves the Thyroid Cancer Progression through Targeting the Caspase 3 and CD274 Expression Levels	8
Impact of Polypharmacy and Risk Factors for Exacerbation of Lower Urinary Tract Symptoms in Patients with Urological Conditions: A Retrospective Study in a Japanese Municipal Hospital	8
Extracellular Vesicles Derived from the Serum of <i>Seriola quinqueradiata</i> Induce Human Umbilical Vein Endothelial Cell Proliferation through Angiogenic Signaling	8
Mogroside Alleviates Diabetes Mellitus and Modulates Intestinal Microflora in Type 2 Diabetic Mice	8
Self-controlled Case Series Study for Acute Kidney Injury after Starting Proton Pump Inhibitors or Potassium-Competitive Acid Blocker in Patients with Cancer Using a Large Claims Database	8
Association between Early Guanfacine Discontinuation and Somnolence for Attention-Deficit/Hyperactivity Disorder	8
Anacardic Acid Derivatives Isolated from Fungal Species <i>Tyromyces fissilis</i> as New Histone Acetyltransferase Inhibitors	8
The Mechanism of 5-Fluorouracil-Induced Hyperpigmentation in HRM-2 Hairless Mice: Focus on the Increase of Blood Vessels	7
Endogenous SOLOIST/MRTFB i4, a Neuronal Isoform of MKL2/MRTFB, Positively and Negatively Regulates SRF Target Immediate Early Genes in Neuro-2a Cells	7
Docosahexaenoic Acid and Eicosapentaenoic Acid Inhibit the Contractile Responses of the Guinea Pig Lower Gastrointestinal Tract	7
Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, a	7
Saikosaponin A Inhibits Growth of Human Bladder Carcinoma T24 and 5637 Cells Both <i>in Vitro</i> and <i>in Vivo</i>	7
Analysis of Risk Factors for Developing Tuberculosis in Patients Who Received Prophylactic Latent Tuberculosis Infection Treatment with Experience of Biologic Medications	7
Involvement of Gap Junctions in Acetylcholine-Induced Endothelium-Derived Hyperpolarization-Type Dilation of Retinal Arterioles in Rats	7
New Drug Delivery Systems for Stable Oral Absorption: Theory, Strategies, and Applications	7
Discover Novel Covalent Inhibitors Targeting FLT3 through Hybrid Virtual Screening Strategy	7
Emedastine Inhibits Th1 and Th2 Cell Differentiation Mediated by Mast Cells	7
Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis	7
Withdrawal: Remote Reminiscence Using Immersive Virtual Reality May Be Efficacious for Reducing Anxiety in Patients with Mild Cognitive Impairment Even in COVID-19 Pandemic: A Case Report	7
Possible Therapeutic Applications of Targeting STAP Proteins in Cancer	7
Inhibition Effect of <i>Eucommia ulmoides</i> Leaf Extract on Interleukin 8 Production by A549 Cells	7
Protective Effects of <i>Coptis chinensis</i> Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells	7
Longitudinal Trend in Antimicrobial Susceptibility among <i>Haemophilus influenzae</i>: A Single-Centre Study in Japan	7
Discovery and Verification of Key Liver Cancer Genes and Alternative Splicing Events Based on Second-Generation Sequencing Data Analysis	7
Foreword	7
Inhibitory Actions of Antidepressants, Hypnotics, and Anxiolytics on Recombinant Human Acetylcholinesterase Activity	7
Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells	7
Influence of Size, Flexibility, Hydrophobicity, Surface Charge, and Surface Chemistry on the Biodistribution of Orally Administered Polymer Nanoparticles	7
RasGRP2 Attenuates Oxygen Deprivation-Induced Autophagy in Vascular Endothelial Cells	7
Biochemical Characterizations of the Putative Amidase Endolysin Ecd18980 Catalytic Domain from <i>Clostridioides difficile</i>	7
Curcumin Is Primarily Distributed in Lung, Spleen and Liver, Metabolized to Glucuronide and Sulfate, and Excreted through Bile and Urine by Using an Amorphous Curcumin Formulation with High Absorbabil	7
Assessment of Risk of Acidosis in Patients with Mild-to-Moderate Chronic Kidney Disease Treated with Intravenous Branched-Chain Amino Acid-Enriched Solution: A Propensity Score Matching Analysis	7
Ketogenic Diet Alleviates Mechanical Allodynia in the Models of Inflammatory and Neuropathic Pain in Male Mice	7
Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using <i>in Silico</i> Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity	6
<i>Ajania purpurea</i> Extract Attenuates LPS-Induced Inflammation in RAW264.7 Cells and Peritonitis Mice	6
Development of a Novel Gastric Process Simulation Model: The Successful Assessment of Bioequivalence and Bioinequivalence of a Biopharmaceutics Classification System Class II Weak Acid Drug	6
Goji Berry Juice Prevents Tumor Necrosis Factor Alpha-Induced Xerostomia in Human Salivary Gland Cells	6
Development, Characterization and Potential Applications of a Multicellular Spheroidal Human Blood–Brain Barrier Model Integrating Three Conditionally Immortalized Cell Lines	6
Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy <i>via</i> Inhibiting Apoptosis and NLRP3 Inflammasome Activation	6
Point Mutation Analysis of the Drug Efflux Pump MexB in Clinical Isolates of <i>Pseudomonas aeruginosa</i>	6
Risk Factors for Treatment Transition in Patients with Low-Risk Atrial Fibrillation Patients Undergoing Anticoagulation Monotherapy: A Large Claims Database Study in Japan	6
Machine Learning-Based Model for Estimating Vancomycin Maintenance Dose to Target the Area under the Concentration Curve of 400–600 mg·h/L in Japanese Patients	6
Phospholipid Scramblase 1 Localizes Proximal to Sphingomyelin Synthase Isoforms but Is Not Involved in Sphingomyelin Synthesis	6
Biotransformation of Morphinone and Its Glutathione Adduct Derived from Morphine by Anaerobic Gut Microbes in Guinea Pigs	6
The Potential Effects of 2,3,4-Trihydroxybenzophenone on the Transient Cerebral Ischemic Stroke in Male Mice	6
Foreword	6
Insights into Dynamic Mechanism of Ligand Binding to Peroxisome Proliferator-Activated Receptor γ toward Potential Pharmacological Applications	6
Development of siRNA Delivery System by Lipid Nanoparticles Modified with Functional Materials for Cancer Treatment	6
Study on the Protective Effect of Schizandrin B against Acetaminophen-Induced Cytotoxicity in Human Hepatocyte	6
Contamination-Free Milling of Ketoprofen Nanoparticles Using Mannitol Medium and Hoover Automatic Muller: Optimization of Effective Design of Experiment	6
Development of a Nanocarrier-Based Splenic B Cell-Targeting System for Loading Antigens <i>in Vitro</i>	6
Effects of Ingested Water Volume on Oral Absorption of Fenofibrate, a BCS Class II Drug, from Micronized and Amorphous Solid Dispersion Formulations in Rats	6
Octa-arginine and Octa-lysine Promote Cell Adhesion through Heparan Sulfate Proteoglycans and Integrins	6
The Combined Use of 5 or More Drugs Is a Factor Related to Lower Adherence to S-1 in S-1 and Oxaliplatin Treatment for Advanced Gastric Cancer	6
Analysis of Risk Factors for Infusion-Related Reactions Following Rituximab Administration in Patients with Desensitization before Renal Transplantation	6

Risk Assessment for Heart Failure in Patients with Type 2 Diabetes Mellitus Treated with Dipeptidyl Peptidase 4 Inhibitor Using a Large Claims Dataset	6
Anticancer Effects of New Disulfiram Analogs	6
Ciclesonide Inhibits SARS-CoV-2 Papain-Like Protease <i>in Vitro</i>	6
Mechanism of Human Cytomegalovirus-Induced Epithelial–Mesenchymal Transition in Glioma Cells <i>via</i> the Upregulation of RIP2 Expression	6
Skin Dryness Induced in the KK-Ay/TaJcl Type 2 Diabetes Mouse Model Deteriorates Following Dapagliflozin Administration	6
Functional Analysis of Modified Caco-2 Cells Carrying CES2A1 as a Model for Intestinal Absorption of Prodrugs	6
Structural Impact Assessment of Cytochrome P450 2A13 Polymorphisms Using Molecular Dynamics Simulations	6
Development of SCAR Markers to Identify Medicinal Cultivars of <i>Paeonia lactiflora</i>	5
Royal Jelly Maintains Epidermal Stem Cell Properties by Repressing Senescence	5
SRF and SRF Cofactor mRNA Expression Is Differentially Regulated by BDNF Stimulation in Cortical Neurons	5
A Novel Lithocholic Acid Derivative Upregulates Detoxification-Related Genes in Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids	5
A Complex of Type I Platelet-Activating Factor Acetylhydrolase (PAF-AH) Catalytic Subunits Switches from α1/α2 Heterodimer to α2/α2 Homodimer during Adipocyte Differentiation of 3T3-L1 Cells	5
The Role of TNF-α in the Pathogenesis of Temporomandibular Disorders	5
Non-neuronal Cholinergic Muscarinic Acetylcholine Receptors in the Regulation of Immune Function	5
Abnormal Pressure Stress Reduces Interleukin-1β-Induced Cyclooxygenase-2 Expression in Cultured Rat Vascular Smooth Muscle Cells	5
Synergistic Effect of Baculovirus-Mediated Endostatin and Angiostatin Combined with Gemcitabine in Hepatocellular Carcinoma	5
LncRNA Snhg5 Attenuates Status Epilepticus Induced Inflammation through Regulating NF-κΒ Signaling Pathway	5
Curculigoside Represses the Proliferation and Metastasis of Osteosarcoma <i>via</i> the JAK/STAT and NF-κB Signaling Pathways	5
Salidroside Induces Apoptosis in Human Gastric Cancer Cells <i>via</i> the Downregulation of ENO1/PKM2/GLUT1 Expression	5
Improved Detection Sensitivity of an Antigen Test for SARS-CoV-2 Nucleocapsid Proteins with Thio-NAD Cycling	5
Medical Economic Benefit Derived from the Use of Tracing Reports by Pharmacy-Based Pharmacists for Pharmaceutical Intervention and Reduction of Leftover Medicines	5
Usefulness of the Albumin–Bilirubin Score in Determining the Initial Dose of Voriconazole for Patients with Liver Cirrhosis	5
Serum Concentrations of Infliximab and IL-6 for Predicting One-Year Discontinuation of Infliximab Treatment Owing to Secondary Non-response in Patients with Rheumatoid Arthritis	5
Association between Inhalation Instruction Method in Community Pharmacies and Inhaler Device Handling Error in Patients with Obstructive Lung Disease: An Evaluation of the Impact of Practical Demonstr	5
Effects of Body Composition on Renal Function Estimates in Older Patients	5
Assessment of Diagnosis Timing of Attention-Deficit/Hyperactivity Disorder in Working-Age Workers with Psychiatric Diseases Using Large Claims Data	5
Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of <i>in Silico</i> Liver-to-Plasma Partition Coefficients	5
Quetiapine Reverses the Behavior and Myelination in Alcohol-Exposed Gestational Diabetes Mellitus Offspring Mice <i>via</i> ERK1/2 Signaling	5
Prevention of Renal Interstitial Fibrosis by Suplatast in a Mouse Model	5
Proton Pumping ATPases: Rotational Catalysis, Physiological Roles in Oral Pathogenic Bacteria, and Inhibitors	5
Functional Domain Mapping of Werner Interacting Protein 1 (WRNIP1)	5
Removal of Soluble ACE2 in VeroE6 Cells by 17β-Estradiol Reduces SARS-CoV-2 Infectivity	5
Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways	5
Impact of Gut Microbiota on the Pharmacokinetics of Glycyrrhizic Acid in Yokukansan, a Kampo Medicine	5
<i>Salvia miltiorrhiza</i> Prevents Methylglyoxal-Induced Glucotoxicity <i>via</i> the Regulation of Apoptosis-Related Pathways and the Glyoxalase System in Human Umbilical Vei	5
Fabrication of 3D-Printed Contact Lens Composed of Polyethylene Glycol Diacrylate for Controlled Release of Azithromycin	5
Qualification of <i>In Vitro</i> Dissolution Absorption System 2 (IDAS2) with Caco-2 and MDCK Cell Monolayers: Dose Sensitivity Study Using BCS Class I and III Drugs	5
Renal Metabolomics Study and Critical Pathway Validation of Shenkang Injection in the Treatment of Chronic Renal Failure	5
Efficacy of Zinc Acetate in the Treatment of Zinc Deficiency in Elderly Inpatients and Effect of Total Dose on Its Replacement Therapy	5
Rapid Screening Detection of Genetically Modified Papaya by Loop-Mediated Isothermal Amplification	5
Clinical Profiles of Japanese Patients with Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis Collected by a Nationwide System from 2006 to 2023	5
Using Bio-Layer Interferometry to Evaluate Anti-PEG Antibody-Mediated Complement Activation	5
Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin	5
BET Inhibitors Induce p53-Independent Growth Arrest in HCT116 Cells <i>via</i> Epigenetic Control of the E2F1/c-<i>MYC</i> Axis	5
Transcriptional Mechanism of the Mouse β4-Galactosyltransferase 6 Gene in Mouse Neuroblastoma Cell Line Neuro-2a	5
Characterization of Novel Cell-Adhesive Peptides for Biomaterial Development	5
Selexipag Improves Lipopolysaccharide-Induced ARDS on C57BL/6 Mice by Modulating the cAMP/PKA and cAMP/Epac1 Signaling Pathways	5
Feasibility Study of Dendrimer-Based TTR-CRISPR pDNA Polyplex for Ocular Amyloidosis <i>in Vitro</i>	5
Astrocytic Responses to Binge Alcohol Intake in the Mouse Hindbrain	5
Identification of the RORα Transcriptional Network Contributes to the Search for Therapeutic Targets in Atherosclerosis	5
A Survey of Near-Miss Dispensing Errors in Hospital Pharmacies in Japan: DEPP-J Study—Multi-Center Prospective Observational Study—	5
<i>trans</i>-Fatty Acids as an Enhancer of Inflammation and Cell Death: Molecular Basis for Their Pathological Actions	4
Upregulated ClC3 Channels/Transporters Elicit Swelling-Activated Cl<sup>−</sup> Currents and Induce Excessive Cell Proliferation in Idiopathic Pulmonary Arterial Hypertension	4
PI3K/AKT1 Signaling Pathway Mediates Sinomenine-Induced Hepatocellular Carcinoma Cells Apoptosis: An <i>in Vitro</i> and <i>in Vivo</i> Study	4
Gambogenic Acid Inhibits Invasion and Metastasis of Melanoma through Regulation of lncRNA MEG3	4
Calculation of Human Melatonin Partial Metabolic Clearance in Healthy Adult Volunteers for Investigation of a Novel <i>in Vivo</i> CYP1A2 Phenotyping Method: A Pilot Study	4
Pharmacological Studies on the Ca<sup>2+</sup> Influx Pathways in Platelet-Activating Factor (PAF)-Induced Mouse Urinary Bladder Smooth Muscle Contraction	4
Expression of the Discoidin Domain Receptor Family Depended on Glucose and Their High Expression in Arterial Tissues in the Rat Model of Type 2 Diabetes	4
Current Status and Perspectives of Therapeutic Antibodies Targeting the Spike Protein S2 Subunit against SARS-CoV-2	4
Quantitative Assessment of the Post-translational Modifications of Human Serum Albumin by Dimethyl Trisulfide	4
Development of a Highly Sensitive and Rapid Liquid Chromatography–Tandem Mass Spectrometric Method Using a Basic Mobile Phase Additive to Determine the Characteristics of the Urinary Metabolites for N	4
Wogonin Attenuates Bleomycin-Induced Pulmonary Fibrosis and Oxidative Stress Injury <i>via</i> the MAPK Signaling Pathway	4
<i>Cry2</i> Alleviates Cisplatin-Induced Cytotoxicity in Mouse Renal Cortex Tubular Cell Lines	4
Exploring IDI2-AS1, OIP5-AS1, and LITATS1: Changes in Long Non-coding RNAs Induced by the Poly I:C Stimulation	4
Accumulation of Toxic Advanced Glycation End-Products Induces Cytotoxicity and Inflammation in Hepatocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells	4
The Effects of Jabara Juice on the Intestinal Permeation of Fexofenadine	4
Importance of Cholesterol Side Chain in the Membrane Stability of Human Erythrocytes	4
Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma <i>via</i> ROS/Mitochondria Pathway	4
Pharmacokinetic and Adsorptive Analyses of Administration of Oral Voriconazole Suspension <i>via</i> Enteral Feeding Tube in Intensive Care Unit Patients	4
Inhibitory Effect of Astragalus Polysaccharide Combined with Cisplatin on Cell Cycle and Migration of Nasopharyngeal Carcinoma Cell Lines	4
Combination Therapy with Betamethasone and Josamycin Demonstrates Superior Therapeutic Efficacy in an NC/Nga Mouse Model of Atopic Dermatitis	4
Ca<sup>2+</sup> Signaling and Proliferation <i>via</i> Ca<sup>2+</sup>-Sensing Receptors in Human Hepatic Stellate LX-2 Cells	4
Decreased Analgesic Effect of Tramadol in Japanese Patients with CYP2D6 Intermediate Metabolizers after Orthopedic Surgery	4
Protective Effect of Salidroside on Acute Kidney Injury in Sepsis by Inhibiting Oxidative Stress, Mitochondrial Damage, and Cell Apoptosis	4
Dlx5 Represses the Transcriptional Activity of PPARγ	4
Therapeutic Drug Monitoring of Antibody Drugs	4
<i>Astragalus</i> Polysaccharide Suppresses Cell Proliferation and Invasion by Up-Regulation of miR-195-5p in Non-small Cell Lung Cancer	4
Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis	4
Regulation of Chloride Channels by Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced α-Defensin 5	4
Rapid Increase of Gastrointestinal P-Glycoprotein Functional Activity in Response to Etoposide Stimulation	4
Detection of Characteristic Phosphatidylcholine Containing Very Long Chain Fatty Acids in Cerebrospinal Fluid from Patients with X-Linked Adrenoleukodystrophy	4
Predicting the Safety of Ocular Iontophoresis Using Reconstructed Human Corneal Epithelial Cells	4
Vitexin Attenuates Non-alcoholic Fatty Liver Disease Lipid Accumulation in High Fat-Diet Fed Mice by Activating Autophagy and Reducing Endoplasmic Reticulum Stress in Liver	4
Extravasation of Noncytotoxic Agents: Skin Injury and Risk Classification	4
Comparison of the Speed of Enrollment for Clinical Trials Conducted by Japanese and Global Pharmaceutical Companies	4
Polyphyllin E Inhibits Proliferation, Migration and Invasion of Ovarian Cancer Cells by Down-Regulating the AKT/NF-κB Pathway	4
<i>MicroRNA-5572</i> Is Associated with Endoplasmic Reticulum Stress Responses in Low Zinc Treated and SOD1 G85R-Transfected HEK293 Cells	4
Nanaomycin K Inhibited Cell Proliferation and Epithelial–Mesenchymal Transition in Renal Cell Carcinoma	4
Pyoluteorin Induces Apoptosis and Autophagy in NSCLC Cells	4
Evaluating the Associated Hyperuricemia Risk with Sodium-Glucose Cotransporter 2 Inhibitors: A Sequence Symmetry Analysis Using the Japanese Administrative Claims Database	4
Possible Involvement of DNA Methylation and Protective Effect of Zebularine on Neuronal Cell Death after Glutamate Excitotoxity	4
Differences in Pharmaceutical Intervention Triggers for the Optimization of Medication by Patient Age: A University Hospital Study	4
Cathepsin G-Induced Cell Aggregation of Breast Cancer MCF-7 Decreases Doxorubicin Sensitivity in a Hypoxia-Inducible Factor-Independent Mechanism	4
Simple Cytosolic and Nuclear Introduction of Boron Compounds Using Cationic Lipids to Enhance Cancer Cell-Killing Activity in Boron Neutron Capture Therapy	4
Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D<sub>3</sub> Biosynthesis Pathways	4