Biological & Pharmaceutical Bulletin

Article	Citations
Neuroprotective Effects of Limonene (+) against Aβ42-Induced Neurotoxicity in a <i>Drosophila</i> Model of Alzheimer’s Disease	52
circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells <i>via</i> Pyroptosis	47
Gastrodin Inhibits H<sub>2</sub>O<sub>2</sub>-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6	42
Lipid Nanoparticles for Cell-Specific <i>in Vivo</i> Targeted Delivery of Nucleic Acids	41
Glabridin Alleviates Inflammation and Nociception in Rodents by Activating BK<sub>Ca</sub> Channels and Reducing NO Levels	33
Resveratrol Attenuates Inflammatory Bowel Disease in Mice by Regulating SUMO1	32
Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats	31
Characterization and Immunological Activities of Polysaccharides from <i>Polygonatum sibiricum</i>	29
<i>Lycium barbarum</i> Polysaccharide Antagonizes LPS-Induced Inflammation by Altering the Glycolysis and Differentiation of Macrophages by Triggering the Degradation of PKM2	23
MiR-140-3p Ameliorates the Progression of Osteoarthritis <i>via</i> Targeting CXCR4	23
Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More	22
Withdrawal: Remote Reminiscence Using Immersive Virtual Reality May Be Efficacious for Reducing Anxiety in Patients with Mild Cognitive Impairment Even in COVID-19 Pandemic: A Case Report	19
Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood–Brain Barrier	19
Application of Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids as a Model of Epithelial Damage and Fibrosis in Inflammatory Bowel Disease	18
Trimethylamine-<i>N</i>-oxide Specifically Impairs Endothelium-Derived Hyperpolarizing Factor-Type Relaxation in Rat Femoral Artery	18
<i>Dendrobium officinale</i> Attenuates Myocardial Fibrosis <i>via</i> Inhibiting EMT Signaling Pathway in HFD/STZ-Induced Diabetic Mice	18
Potential Mechanisms Underlying the Hepatic–Protective Effects of Danshensu on Iron Overload Mice	18
Risk Factors for Pseudoaldosteronism with Yokukansan Use: Analysis Using the Japanese Adverse Drug Report (JADER) Database	18
Ginsenoside Rd Inhibits Glioblastoma Cell Proliferation by Up-Regulating the Expression of miR-144-5p	18
Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell–Cell Junctions and Vascular Permeability	17
TGF-β and Cancer Immunotherapy	17
Dexmedetomidine Protects SK-N-SH Nerve Cells from Oxidative Injury by Maintaining Iron Homeostasis	17
Astragaloside IV Ameliorates Cognitive Impairment and Neuroinflammation in an Oligomeric Aβ Induced Alzheimer’s Disease Mouse Model <i>via</i> Inhibition of Microglial Activation and NADPH	17
Therapeutic Application of Small Extracellular Vesicles (sEVs): Pharmaceutical and Pharmacokinetic Challenges	17
Protective Effect of Saponins-Enriched Fraction of <i>Gynostemma pentaphyllum</i> against High Choline-Induced Vascular Endothelial Dysfunction and Hepatic Damage in Mice	16

Beta-Asarone Alleviates Myocardial Ischemia–Reperfusion Injury by Inhibiting Inflammatory Response and NLRP3 Inflammasome Mediated Pyroptosis	16
Norisoboldine Attenuates Sepsis-Induced Acute Lung Injury by Modulating Macrophage Polarization <i>via</i> PKM2/HIF-1α/PGC-1α Pathway	16
Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates	16
Anti-metastatic Effects of Baicalein by Targeting STAT3 Activity in Breast Cancer Cells	16
Low Levels of Brain-Derived Neurotrophic Factor Trigger Self-aggregated Amyloid β-Induced Neuronal Cell Death in an Alzheimer’s Cell Model	16
Association of Hypnotic Drug Use with Fall Incidents in Hospitalized Elderly Patients: A Case-Crossover Study	15
Protective Effect of Panduratin A on Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Cells and Acute Kidney Injury in Mice	15
Drug Repositioning and Target Finding Based on Clinical Evidence	15
Induced Prostanoid Synthesis Regulates the Balance between Th1- and Th2-Producing Inflammatory Cytokines in the Thymus of Diet-Restricted Mice	15
Ampelopsin Inhibits Breast Cancer Cell Growth through Mitochondrial Apoptosis Pathway	14
Propofol Attenuates Inflammatory Damage <i>via</i> Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury	14
Nicotine Enhances Object Recognition Memory <i>via</i> Stimulating α4β2 and α7 Nicotinic Acetylcholine Receptors in the Medial Prefrontal Cortex of Mice	14
Kosen-cha, a Polymerized Catechin-Rich Green Tea, as a Potential Functional Beverage for the Reduction of Body Weight and Cardiovascular Risk Factors: A Pilot Study in Obese Patients	14
Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells	14
Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis	14
Ferulic Acid Ameliorates Isoproterenol-Induced Heart Failure by Decreasing Oxidative Stress and Inhibiting Cardiocyte Apoptosis <i>via</i> Activating Nrf2 Signaling Pathway in Rats	13
Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma <i>via</i> ROS/Mitochondria Pathway	13
Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway	13
Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level	13
Loganin Inhibits Lipopolysaccharide-Induced Inflammation and Oxidative Response through the Activation of the Nrf2/HO-1 Signaling Pathway in RAW264.7 Macrophages	13
Galangin Reverses Hepatic Fibrosis by Inducing HSCs Apoptosis <i>via</i> the PI3K/Akt, Bax/Bcl-2, and Wnt/β-Catenin Pathway in LX-2 Cells	13
MicroRNA-221 Upregulates the Expression of P-gp and Bcl-2 by Activating the Stat3 Pathway to Promote Doxorubicin Resistance in Osteosarcoma Cells	13
Elaidic Acid Potentiates Extracellular ATP-Induced Apoptosis <i>via</i> the P2X<sub>7</sub>-ROS-ASK1-p38 Axis in Microglial Cell Lines	12
Increased 20S Proteasome Expression and the Effect of Bortezomib during Cisplatin-Induced Muscle Atrophy	12
Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes	12
The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells	12
Therapeutic Advantage of Tyk2 Inhibition for Treating Autoimmune and Chronic Inflammatory Diseases	12
Edaravone Improves Intermittent Hypoxia-Induced Cognitive Impairment and Hippocampal Damage in Rats	12
The Role of TNF-α in the Pathogenesis of Temporomandibular Disorders	12
Kaempferol Protects Renal Fibrosis through Activating the BMP-7-Smad1/5 Signaling Pathway	12
Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft	12
Involvement of A2B Receptor in DNA Damage Response and Radiosensitizing Effect of A2B Receptor Antagonists on Mouse B16 Melanoma	12
Synergistic Interaction of Ochratoxin A and Acrylamide Toxins in Human Kidney and Liver Cells	11
Comparative Analysis of Anti-inflammatory Activity of the Constituents of the Rhizome of <i>Cnidium officinale</i> Using Rat Hepatocytes	11
Trends of the Use of Anti-methicillin-Resistant <i>Staphylococcus aureus</i> Agents in Japan Based on Sales Data from 2006 to 2015	11
L-Theanine Attenuates Isoflurane-Induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice	11
Oridonin Suppresses Human Gastric Cancer Growth <i>in Vitro</i> and <i>in Vivo</i> <i>via</i> Inhibition of VEGF, Integrin β3, and PCNA	11
Edaravone Ameliorates Cerebral Ischemia–Reperfusion Injury by Downregulating Ferroptosis <i>via</i> the Nrf2/FPN Pathway in Rats	11
Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23	11
STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses	11
Impact of Gut Microbiota on the Pharmacokinetics of Glycyrrhizic Acid in Yokukansan, a Kampo Medicine	10
Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia	10
Improved Detection Sensitivity of an Antigen Test for SARS-CoV-2 Nucleocapsid Proteins with Thio-NAD Cycling	10
Cholestyramine, a Bile Acid Sequestrant, Increases Cecal Short Chain Fatty Acids and Intestinal Immunoglobulin A in Mice	10
Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9	10
Russelioside A, a Pregnane Glycoside from <i>Caralluma tuberculate</i>, Inhibits Cell-Intrinsic NF-κB Activity and Metastatic Ability of Breast Cancer Cells	10
Cigarette Smoke Extract and Its Cytotoxic Factor Acrolein Inhibit Nitric Oxide Production in Human Vascular Endothelial Cells	10
Docetaxel Upregulates HMGB1 Levels in Non-small Cell Lung Cancer	10
Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, a	10
Microbial Rhodopsins as Multi-functional Photoreactive Membrane Proteins for Optogenetics	10

Study on the Inhibitory Activity and Possible Mechanism of Myriocin on Clinically Relevant Drug-Resistant <i>Candida albicans</i> and Its Biofilms	10
Osthole Improves Cognitive Function of Vascular Dementia Rats: Reducing Aβ Deposition <i>via</i> Inhibition NLRP3 Inflammasome	10
Rosmarinic Acid Protects Mice from Concanavalin A-Induced Hepatic Injury through AMPK Signaling	10
Protective Effect of Fuzi Lizhong Decoction against Non-alcoholic Fatty Liver Disease <i>via</i> Anti-inflammatory Response through Regulating p53 and PPARG Signaling	10
Germacrone Reduces Cisplatin-Induced Toxicity of Renal Proximal Tubular Cells <i>via</i> Inhibition of Organic Cation Transporter	10
Reduced Serum Cholesterol and Triglyceride Levels in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD)-Induced Mouse Model of Non-alcoholic Steatohepatitis (NASH)	9
Effects of Proton Pump Inhibitors on Survival Outcomes in Patients with Metastatic or Unresectable Urothelial Carcinoma Treated with Pembrolizumab	9
Development of a Diagnostic Screening Strategy for Niemann–Pick Diseases Based on Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analyses of <i>N</i>-Palmitoyl-<i>O</	9
Development, characterization and potential applications of a multicellular spheroidal human blood-brain barrier model integrating three conditionally immortalized cell lines	9
Pegfilgrastim (PEG-G-CSF) Induces Anti-polyethylene Glycol (PEG) IgM <i>via</i> a T Cell-Dependent Mechanism	9
Activation of Host Immune Cells by Probiotic-Derived Extracellular Vesicles <i>via</i> TLR2-Mediated Signaling Pathways	9
Azithromycin Inhibits Constitutive Airway Epithelial Sodium Channel Activation <i>in Vitro</i> and Modulates Downstream Pathogenesis <i>in Vivo</i>	9
Detection of Abacavir-Induced Structural Alterations in Human Leukocyte Antigen-B*57 : 01 Using Phage Display	9
Sinomenine Can Inhibit the Growth and Invasion Ability of Retinoblastoma Cell through Regulating PI3K/AKT Signaling Pathway	9
Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Hum	9
β-Aminoisobutyric Acid Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice	9
A Novel Binary Supercooled Liquid Formulation for Transdermal Drug Delivery	9
Induction of PD-L1 by Nitric Oxide <i>via</i> JNK Activation in A172 Glioblastoma Cells	9
Tapentadol in Cancer Patients with Neuropathic Pain: A Comparison of Methadone, Oxycodone, Fentanyl, and Hydromorphone	9
Simultaneous Screening of SARS-CoV-2 Omicron and Delta Variants Using High-Resolution Melting Analysis	9
Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways	9
Epigallocatechin-3-Gallate Suppresses the Expression of TNF-α-Induced MMP-1 <i>via</i> MAPK/ERK Signaling Pathways in Human Dermal Fibroblasts	9
Pannexin 1 Mediates Gastric Cancer Cell Epithelial–Mesenchymal Transition <i>via</i> Aquaporin 5	9
Safety of Remdesivir in 20 Children with COVID-19—Case Series—	8
Andrographolide/Phospholipid/Cyclodextrin Complex-Loaded Nanoemulsion: Preparation, Optimization, <i>in Vitro</i> and <i>in Vivo</i> Evaluation	8
Gomisin N Exerts Anti-liver Cancer Effects and Regulates PI3K–Akt and mTOR–ULK1 Pathways <i>in Vitro</i>	8
Berberine Encapsulated in Exosomes Derived from Platelet-Rich Plasma Promotes Chondrogenic Differentiation of the Bone Marrow Mesenchymal Stem Cells <i>via</i> the Wnt/β-Catenin Pathway	8
Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1	8
Morphine Stimulates Migration and Growth and Alleviates the Effects of Chemo Drugs <i>via</i> AMPK-Dependent Induction of Epithelial–Mesenchymal Transition in Esophageal Carcinoma Cells	8
Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery	8
Exopolysaccharide Produced by Plant-Derived <i>Lactobacillus plantarum</i> SN35N Exhibits Antiviral Activity	8
Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist	8
Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice	8
Linarin Protects the Kidney against Ischemia/Reperfusion Injury <i>via</i> the Inhibition of Bioactive ETS2/IL-12	8
WSF-7 Inhibits Obesity-Mediated PPARγ Phosphorylation and Improves Insulin Sensitivity in 3T3-L1 Adipocytes	8
Oroxylin A Exerts Its Antitumor Effects in Human Gallbladder Cancer <i>via</i> Inhibition of the PTEN/PI3K/AKT Signaling Pathway	8
<i>trans</i>-Fatty Acids as an Enhancer of Inflammation and Cell Death: Molecular Basis for Their Pathological Actions	8
Androgen-Dependent Differences in the Amounts of <i>CYP</i> mRNAs in the Pig Kidney	8
Trends Associated with Hemorrhoids in Japan: Data Mining of Medical Information Datasets and the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) Open Data Japa	8
Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice	8
The Japanese Herbal (Kampo) Medicine Hochuekkito Attenuates Lung Inflammation in Lung Emphysema	8
The Lysosome Pathway Degrades CD81 on the Cell Surface by Poly-ubiquitination and Clathrin-Mediated Endocytosis	8
Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Indivi	8
Anti-obesity Effect of Fermented Persimmon Extracts <i>via</i> Activation of AMP-Activated Protein Kinase	8
Reconstituted Human Organ Models as a Translational Tool for Human Organ Response: Definition, Expectations, Cases, and Strategies for Implementation in Drug Discovery and Development	8
Accumulation of Toxic Advanced Glycation End-Products Induces Cytotoxicity and Inflammation in Hepatocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells	8
Effects of Cholesterol on Membrane Stability of Human Erythrocytes	8
Extract of <i>Salvia przewalskii</i> Repair Tissue Damage in Chronic Hypoxia Maybe through the RhoA–ROCK Signalling Pathway	8
Hepatoprotective Effect of Neoagarooligosaccharide <i>via</i> Activation of Nrf2 and Enhanced Antioxidant Efficacy	8
The Light-Inducible Genes <i>Per2</i>, <i>Cry1a</i>, and <i>Cry2a</i> Regulate Oxidative Status in Zebrafish	8
A Lipid-Based Nanocarrier Containing Active Vitamin D<sub>3</sub> Ameliorates NASH in Mice <i>via</i> Direct and Intestine-Mediated Effects on Liver Inflammation	8
Hydrogen Sulfide Improves Functional Recovery in Rat Traumatic Spinal Cord Injury Model by Inducing Nuclear Translocation of NF-E2-Related Factor 2	8
Trends of Antifungal Use Based on Sales Data in Japan from 2006 to 2015	8
Prescription of Colchicine with Other Dangerous Concomitant Medications: A Nation-Wide Survey Using the Japanese Claims Database	7
Comparison of the Safety and Effectiveness of Four Direct Oral Anticoagulants in Japanese Patients with Nonvalvular Atrial Fibrillation Using Real-World Data	7
Inhibitory effect of Astragalus Polysaccharide combined with cisplatin on cell cycle and migration of nasopharyngeal carcinoma cell lines	7
Dexmedetomidine Reduces the Lidocaine-Induced Neurotoxicity by Inhibiting Inflammasome Activation and Reducing Pyroptosis in Rats	7
Polyphyllin E Inhibits Proliferation, Migration and Invasion of Ovarian Cancer Cells by Down-Regulating the AKT/NF-κB Pathway	7
3′,4′,7-Trihydroxyflavone Downregulates NO Production in LPS- or IFN-γ-Activated MG6 Microglial Cells by Attenuating the JNK–STAT1 Pathway	7
Curculigoside Represses the Proliferation and Metastasis of Osteosarcoma <i>via</i> the JAK/STAT and NF-κB Signaling Pathways	7
Development of an SS-Cleavable pH-Activated Lipid-Like Material (ssPalm) as a Nucleic Acid Delivery Device	7
8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice	7
Influence of Crocetin, a Natural Carotenoid Dicarboxylic Acid in Saffron, on L-Type Ca<sup>2+</sup> Current, Intracellular Ca<sup>2+</sup> Handling and Contraction of Isolated	7
<i>Dendrobium nobile</i> Alkaloids Protects against H<sub>2</sub>O<sub>2</sub>-Induced Neuronal Injury by Suppressing JAK–STATs Pathway Activation in N2A Cells	7
Pharmaceutical Care Contributes to the Advanced Management of Patients Receiving Immune Checkpoint Inhibitors	7
Signal Detection of Potential Hepatotoxic Drugs: Case-Control Study Using Both a Spontaneous Reporting System and Electronic Medical Records	7
Synthesis and Biological Evaluation of Salicylic Acid Analogues of Celecoxib as a New Class of Selective Cyclooxygenase-1 Inhibitor	7
Methylglyoxal-Derived Advanced Glycation End Products (AGE4) Promote Cell Proliferation and Survival in Renal Cell Carcinoma Cells through the RAGE/Akt/ERK Signaling Pathways	7
V-ATPase a3 Subunit in Secretory Lysosome Trafficking in Osteoclasts	7
Safety and Biocompatibility of Mupirocin Nanoparticle-Loaded Hydrogel on Burn Wound in Rat Model	7
Transport Characteristics of 5-Aminosalicylic Acid Derivatives Conjugated with Amino Acids <i>via</i> Human H<sup>+</sup>-Coupled Oligopeptide Transporter PEPT1	7
High-Dose Vitamin C Administration Inhibits the Invasion and Proliferation of Melanoma Cells in Mice Ovary	7
Macrophage Response Driven by Extracellular ATP	7
Salidroside Induces Apoptosis in Human Gastric Cancer Cells <i>via</i> the Downregulation of ENO1/PKM2/GLUT1 Expression	7
Equol Inhibits Mushroom Tyrosinase <i>in Vitro</i> through Tight Binding	7
Pharmacokinetics, Tissue Distribution, and Druggability Prediction of the Natural Anticancer Active Compound Cytisine <i>N</i>-Isoflavones Combined with Computer Simulation	7
Reciprocal Relationship between Ca<sup>2+</sup> Signaling and Ca<sup>2+</sup>-Gated Ion Channels as a Potential Target for Drug Discovery	7
Emodin Suppresses the Migration and Invasion of Melanoma Cells	7
Amelioration of the Lipogenesis, Oxidative Stress and Apoptosis of Hepatocytes by a Novel Proteoglycan from <i>Ganoderma lucidum</i>	7
Mitochondrial Uncouplers Confer Protection by Activating AMP-Activated Protein Kinase to Inhibit Neuroinflammation Following Intracerebral Hemorrhage	7

Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice	7
Effect of <i>N</i>-Acetyl Cysteine on Renal Interstitial Fibrosis in Mice	7
Investigating DNA Methylation of <i>SHATI/NAT8L</i> Promoter Sites in Blood of Unmedicated Patients with Major Depressive Disorder	7
Evaluation of Proteinuria Using Urine Protein : Creatine Ratio in Treatment with Molecular Targeted Agents for Advanced Renal Cell Carcinoma	7
<i>Ziyuglycoside II</i> Inhibits Rotavirus Induced Diarrhea Possibly <i>via</i> TLR4/NF-κB Pathways	7
Dexmedetomidine relieved neuropathic pain and inflammation response induced by CCI through HMGB1/TLR4/NF-κB signal pathway	7
Total Saponins from <i>Paris forrestii</i> Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp <i>via</i> ERK Signaling Pathway	7
Pharmacology of Antagonism of GPCR	7
Puerarin Protects against Myocardial Ischemia/Reperfusion Injury by Inhibiting Ferroptosis	7
Nicotine Enhances Firing Activity of Layer 5 Pyramidal Neurons in the Medial Prefrontal Cortex through Inhibition of Kv7 Channels	6
Artesunate Provides Neuroprotection against Cerebral Ischemia–Reperfusion Injury <i>via</i> the TLR-4/NF-κB Pathway in Rats	6
Establishment of Three Types of Immortalized Human Skin Stem Cell Lines Derived from the Single Donor	6
Estrogen Receptor β as a Possible Double-Edged Sword Molecule in Breast Cancer: A Mechanism of Alteration of Its Role by Exposure to Endocrine-Disrupting Chemicals	6
Oxidative Formation of Methylglyoxal in Glycerol Preparations during Storage	6
Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin	6
Insights into Dynamic Mechanism of Ligand Binding to Peroxisome Proliferator-Activated Receptor γ toward Potential Pharmacological Applications	6
Effects of Oxidation of Human Serum Albumin on the Binding of Aripiprazole	6
Angiotensin (1–7) Attenuates the Nociceptive Behavior Induced by Substance P and NMDA <i>via</i> Spinal MAS1	6
Target Therapeutic Ranges of Anti-MRSA Drugs, Linezolid, Tedizolid and Daptomycin, and the Necessity of TDM	6
Inhibitory Effect of the Traditional Chinese Medicine <i>Ephedra sinica granules</i> on <i>Streptococcus pneumoniae</i> Pneumolysin	6
PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from <i>Eclipta prostrata</i> L.	6
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells <i>via</i> ROS Production and PI3K/AKT Pathway Inhibition	6
Low Expression of Rasal2 Promotes Non-small Cell Lung Cancer Metastasis through Ras/ERK Pathway	6
Quantitative Proteomics-Based Blood–Brain Barrier Study	6
Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury <i>via</i> Suppression of Macrophage Involved Inflammation	6
Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine	6
Latifolin Inhibits Oxidative Stress-Induced Senescence <i>via</i> Upregulation of SIRT1 in Human Dermal Fibroblasts	6
Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling	6
<i>Opuntia ficus</i> <i>indica</i> Fruits Ameliorate Cisplatin-Induced Nephrotoxicity in Mice	6
Synergistic Antinociceptive Activity of Tramadol/Acetaminophen Combination Mediated by μ-Opioid Receptors	6
Deletion of TRPC3 or TRPC6 Fails to Attenuate the Formation of Inflammation and Fibrosis in Non-alcoholic Steatohepatitis	6
Inhibition of Stearoyl-CoA Desaturase 1 Potentiates Anti-tumor Activity of Amodiaquine in Non-small Cell Lung Cancer	6
Yi-Zhi-Fang-Dai Formula Exerts a Protective Effect on the Injury of Tight Junction Scaffold Proteins <i>in Vitro</i> and <i>in Vivo</i> by Mediating Autophagy through Regulatio	6
Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells	6
Use of Iontophoresis Technology for Transdermal Delivery of a Minimal mRNA Vaccine as a Potential Melanoma Therapeutic	6
Licochalcone B Induced Apoptosis and Autophagy in Osteosarcoma Tumor Cells <i>via</i> the Inactivation of PI3K/AKT/mTOR Pathway	6
Establishment of a Simple Method for Inducing Neuronal Differentiation of P19 EC Cells without Embryoid Body Formation and Analysis of the Role of Histone Deacetylase 8 Activity in This Differentiatio	6
Anti-allergic Inflammatory Components from the Leaves of <i>Piper crocatum</i> Ruiz & Pav.	6
Three-Dimensional Culture of Umbilical Cord Mesenchymal Stem Cells Effectively Promotes Platelet Recovery in Immune Thrombocytopenia	6
Surface Modification of Liposomes Using IR700 Enables Efficient Controlled Contents Release Triggered by Near-IR Light	6
High-Dose Vitamin C Exerts Its Anti-cancer Effects in a Xenograft Model of Colon Cancer by Suppressing Angiogenesis	6
Role of Mitochondrial Dysfunction in the Pathogenesis of Cisplatin-Induced Myotube Atrophy	6
Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells	6
Risk Factors for Major Bleeding and Clinically Relevant Non-major Bleeding in Japanese Patients Treated with Edoxaban	6
Expression, Purification and Characterization of CAR/NCOA-1 Tethered Protein in <i>E. coli</i> Using Maltose-Binding Protein Fusion Tag and Gelatinized Corn Starch	6
<i>In Vitro</i> Inhibitory Effects of Sesamin on CYP4F2 Activity	6
Effect of Cinacalcet on the Redox Status of Albumin in Secondary Hyperparathyroidism Patients Receiving Hemodialysis	6
Strengthening the Competitiveness of Japan’s Pharmaceutical Industry: Analysis of Country Differences in the Origin of New Drugs and Japan’s Highly Productive Firm	6
Predicting Method for the Human Plasma Concentration–Time Profile of a Monoclonal Antibody from the Half-life of Non-human Primates	6
One-Pot Process for the Production of Ginsenoside Rd by Coupling Enzyme-Assisted Extraction with Selective Enzymolysis	6
The Role of Potassium Channels in Chronic Stress-Induced Brain Injury	6
Polyherbal Formulation Enhancing Cerebral Slow Waves in Sleeping Rats	6
Effects of Bepridil and Pimozide, Existing Medicines Capable of Blocking T-Type Ca<sup>2+</sup> Channels, on Visceral Pain in Mice	6
Different Renal Chronotoxicity of Bromobenzene and Its Intermediate Metabolites in Mice	6
<i>Acanthopanax senticosus</i> Root Extract Exerts Dual Action on Mouse Ileal Smooth Muscle Function, Leading to Modulation of Gastrointestinal Motility	6
Acute Ramelteon Treatment Maintains the Cardiac Rhythms of Rats during Non-REM Sleep	6
Effect of Ginsenoside Rb2 on a Myocardial Cell Model of Coronary Heart Disease through Nrf2/HO-1 Signaling Pathway	6
Topical Xerostomia Treatment with Hyaluronate Sheets Containing Pilocarpine	6
Development of a Competitive Enzyme-Linked Immunosorbent Assay for the Determination of Sunitinib Unaffected by Light-Induced Isomerization	5
Cytotoxic Effects of Water-Soluble Extracts of Coarse and Fine Atmospheric Particulate Matter on Mast Cell Lines	5
Role of Epoxyeicosatrienoic Acids in Acetylcholine-Induced Dilation of Rat Retinal Arterioles <i>in Vivo</i>	5
PI3K/AKT1 Signaling Pathway Mediates Sinomenine-Induced Hepatocellular Carcinoma Cells Apoptosis: An <i>in Vitro</i> and <i>in Vivo</i> Study	5
NSC23766 and Ehop016 Suppress Herpes Simplex Virus-1 Replication by Inhibiting Rac1 Activity	5
Suppression of Hepatic Stellate Cell Death by Toxic Advanced Glycation End-Products	5
The Effect of Liver Hydrolysate on Chronic Ethanol-Induced Hepatic Injury in Normal Rats	5
Increased Expression of Sema3C Indicates a Poor Prognosis and Is Regulated by miR-142-5p in Glioma	5
Involvement of the Hippocampal Alpha2A-Adrenoceptors in Anxiety-Related Behaviors Elicited by Intermittent REM Sleep Deprivation-Induced Stress in Mice	5
LncRNA Snhg5 Attenuates Status Epilepticus Induced Inflammation through Regulating NF-κΒ Signaling Pathway	5
Inflammation-Induced Attenuation of Prostaglandin D<sub>2</sub> Elimination across Rat Blood–Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug R	5
Comparison of the Stimulatory and Inhibitory Effects of Steroid Hormones and α-Naphthoflavone on Steroid Hormone Hydroxylation Catalyzed by Human Cytochrome P450 3A Subfamilies	5
Increased Vancomycin Clearance in Patients with Solid Malignancies	5
Isosteviol Sodium Attenuates High Fat/High Cholesterol-Induced Kidney Dysfunction by Inhibiting Inflammation, Oxidative Stress and Apoptosis	5
Overexpressed Hsa_circ_0001326 Contributes to the Decreased Cell Viability in SWAN71 Cells by Regulating MiR-186-5p/p27 Kip1 Axis	5
Effective Anticancer Therapy by Combination of Nanoparticles Encapsulating Chemotherapeutic Agents and Weak Electric Current	5
Indomethacin, a Non-steroidal Anti-inflammatory Drug, Induces Skin Dryness <i>via</i> PPARγ in Mice	5
Pyoluteorin Induces Apoptosis and Autophagy in NSCLC Cells	5
Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange S	5
Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1	5
Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma	5
Evaluation of Agonistic Activity of Fluorinated and Nonfluorinated Fentanyl Analogs on μ-Opioid Receptor Using a Cell-Based Assay System	5
Mechanotransduction-Targeting Drugs Attenuate Stiffness-Induced Hepatic Stellate Cell Activation <i>in Vitro</i>	5
Lag Time for New Innovative, First-in-Class, Drug Approval in Japan	5
Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice	5
Antidepressant Effect of Intracerebroventricularly Administered Deltorphin Analogs in the Mouse Tail Suspension Test	5
The Physiological and Pathophysiological Role of IL-6/STAT3-Mediated Signal Transduction and STAT3 Binding Partners in Therapeutic Applications	5
Vitexin Attenuates Non-alcoholic Fatty Liver Disease Lipid Accumulation in High Fat-Diet Fed Mice by Activating Autophagy and Reducing Endoplasmic Reticulum Stress in Liver	5
Pharmacokinetic and Adsorptive Analyses of Administration of Oral Voriconazole Suspension <i>via</i> Enteral Feeding Tube in Intensive Care Unit Patients	5
Hesperidin Inhibits UVB-Induced VEGF Production and Angiogenesis <i>via</i> the Inhibition of PI3K/Akt Pathway in HR-1 Hairless Mice	5
LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance <i>via</i> Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes	5
Topical Application of BMS-509744, a Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase, Ameliorates Imiquimod-Induced Skin Inflammation in Mice	5
The Many Roles of Lysophospholipid Mediators and Japanese Contributions to This Field	5
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells	5
Effects of Uremic Toxins on the Binding of Aripiprazole to Human Serum Albumin	5
Cytoprotective Effects Evaluation of a Novel Danshensu Derivative DEX-018 against Oxidative Stress Injury in HUVECs	5
Daily Meal Supplemented with Astaxanthin-Enriched Yolk Has Mitigative Effects against Hypertension in Spontaneously Hypertensive Rats	5