Biological & Pharmaceutical Bulletin

Article	Citations
<i>Lycium barbarum</i> Polysaccharide Antagonizes LPS-Induced Inflammation by Altering the Glycolysis and Differentiation of Macrophages by Triggering the Degradation of PKM2	34
Norisoboldine Attenuates Sepsis-Induced Acute Lung Injury by Modulating Macrophage Polarization <i>via</i> PKM2/HIF-1α/PGC-1α Pathway	31
TGF-β and Cancer Immunotherapy	31
Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood–Brain Barrier	27
Withdrawal: Remote Reminiscence Using Immersive Virtual Reality May Be Efficacious for Reducing Anxiety in Patients with Mild Cognitive Impairment Even in COVID-19 Pandemic: A Case Report	25
Astragaloside IV Ameliorates Cognitive Impairment and Neuroinflammation in an Oligomeric Aβ Induced Alzheimer’s Disease Mouse Model <i>via</i> Inhibition of Microglial Activation and NADPH	22
Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates	21
Protective Effect of Panduratin A on Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Cells and Acute Kidney Injury in Mice	20
Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell–Cell Junctions and Vascular Permeability	20
Anti-metastatic Effects of Baicalein by Targeting STAT3 Activity in Breast Cancer Cells	20
Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis	20
Edaravone Ameliorates Cerebral Ischemia–Reperfusion Injury by Downregulating Ferroptosis <i>via</i> the Nrf2/FPN Pathway in Rats	19
Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma <i>via</i> ROS/Mitochondria Pathway	18
Galangin Reverses Hepatic Fibrosis by Inducing HSCs Apoptosis <i>via</i> the PI3K/Akt, Bax/Bcl-2, and Wnt/β-Catenin Pathway in LX-2 Cells	18
Nicotine Enhances Object Recognition Memory <i>via</i> Stimulating α4β2 and α7 Nicotinic Acetylcholine Receptors in the Medial Prefrontal Cortex of Mice	17
Ampelopsin Inhibits Breast Cancer Cell Growth through Mitochondrial Apoptosis Pathway	17
Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells	17
Loganin Inhibits Lipopolysaccharide-Induced Inflammation and Oxidative Response through the Activation of the Nrf2/HO-1 Signaling Pathway in RAW264.7 Macrophages	16
Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway	16
Therapeutic Advantage of Tyk2 Inhibition for Treating Autoimmune and Chronic Inflammatory Diseases	16
Increased 20S Proteasome Expression and the Effect of Bortezomib during Cisplatin-Induced Muscle Atrophy	16
The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells	16
Activation of Host Immune Cells by Probiotic-Derived Extracellular Vesicles <i>via</i> TLR2-Mediated Signaling Pathways	16
The Role of TNF-α in the Pathogenesis of Temporomandibular Disorders	16
Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft	15

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Hum	15
MicroRNA-221 Upregulates the Expression of P-gp and Bcl-2 by Activating the Stat3 Pathway to Promote Doxorubicin Resistance in Osteosarcoma Cells	15
Epigallocatechin-3-Gallate Suppresses the Expression of TNF-α-Induced MMP-1 <i>via</i> MAPK/ERK Signaling Pathways in Human Dermal Fibroblasts	15
Artesunate Provides Neuroprotection against Cerebral Ischemia–Reperfusion Injury <i>via</i> the TLR-4/NF-κB Pathway in Rats	14
Russelioside A, a Pregnane Glycoside from <i>Caralluma tuberculate</i>, Inhibits Cell-Intrinsic NF-κB Activity and Metastatic Ability of Breast Cancer Cells	14
Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level	14
Puerarin Protects against Myocardial Ischemia/Reperfusion Injury by Inhibiting Ferroptosis	14
Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes	14
Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9	13
STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses	13
Impact of Gut Microbiota on the Pharmacokinetics of Glycyrrhizic Acid in Yokukansan, a Kampo Medicine	13
Germacrone Reduces Cisplatin-Induced Toxicity of Renal Proximal Tubular Cells <i>via</i> Inhibition of Organic Cation Transporter	13
Comparative Analysis of Anti-inflammatory Activity of the Constituents of the Rhizome of <i>Cnidium officinale</i> Using Rat Hepatocytes	13
Ferulic Acid Ameliorates Isoproterenol-Induced Heart Failure by Decreasing Oxidative Stress and Inhibiting Cardiocyte Apoptosis <i>via</i> Activating Nrf2 Signaling Pathway in Rats	13
Salidroside Induces Apoptosis in Human Gastric Cancer Cells <i>via</i> the Downregulation of ENO1/PKM2/GLUT1 Expression	12
Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23	12
Cigarette Smoke Extract and Its Cytotoxic Factor Acrolein Inhibit Nitric Oxide Production in Human Vascular Endothelial Cells	12
Hydrogen Sulfide Improves Functional Recovery in Rat Traumatic Spinal Cord Injury Model by Inducing Nuclear Translocation of NF-E2-Related Factor 2	12
Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia	12
Insights into Dynamic Mechanism of Ligand Binding to Peroxisome Proliferator-Activated Receptor γ toward Potential Pharmacological Applications	12
Development, Characterization and Potential Applications of a Multicellular Spheroidal Human Blood–Brain Barrier Model Integrating Three Conditionally Immortalized Cell Lines	11
<i>trans</i>-Fatty Acids as an Enhancer of Inflammation and Cell Death: Molecular Basis for Their Pathological Actions	11
Use of Iontophoresis Technology for Transdermal Delivery of a Minimal mRNA Vaccine as a Potential Melanoma Therapeutic	11
Trends of the Use of Anti-methicillin-Resistant <i>Staphylococcus aureus</i> Agents in Japan Based on Sales Data from 2006 to 2015	11
Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist	11
Pannexin 1 Mediates Gastric Cancer Cell Epithelial–Mesenchymal Transition <i>via</i> Aquaporin 5	11
Inhibitory Effect of Astragalus Polysaccharide Combined with Cisplatin on Cell Cycle and Migration of Nasopharyngeal Carcinoma Cell Lines	11
Study on the Inhibitory Activity and Possible Mechanism of Myriocin on Clinically Relevant Drug-Resistant <i>Candida albicans</i> and Its Biofilms	11
Rosmarinic Acid Protects Mice from Concanavalin A-Induced Hepatic Injury through AMPK Signaling	11
Microbial Rhodopsins as Multi-functional Photoreactive Membrane Proteins for Optogenetics	11
Effects of Proton Pump Inhibitors on Survival Outcomes in Patients with Metastatic or Unresectable Urothelial Carcinoma Treated with Pembrolizumab	11
Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery	11
Reciprocal Relationship between Ca<sup>2+</sup> Signaling and Ca<sup>2+</sup>-Gated Ion Channels as a Potential Target for Drug Discovery	10
Protective Effect of Fuzi Lizhong Decoction against Non-alcoholic Fatty Liver Disease <i>via</i> Anti-inflammatory Response through Regulating p53 and PPARG Signaling	10
The Physiological and Pathophysiological Role of IL-6/STAT3-Mediated Signal Transduction and STAT3 Binding Partners in Therapeutic Applications	10
V-ATPase a3 Subunit in Secretory Lysosome Trafficking in Osteoclasts	10
Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways	10
Signal Detection of Potential Hepatotoxic Drugs: Case-Control Study Using Both a Spontaneous Reporting System and Electronic Medical Records	10
Licochalcone B Induced Apoptosis and Autophagy in Osteosarcoma Tumor Cells <i>via</i> the Inactivation of PI3K/AKT/mTOR Pathway	10
Polyphyllin E Inhibits Proliferation, Migration and Invasion of Ovarian Cancer Cells by Down-Regulating the AKT/NF-κB Pathway	10
Exopolysaccharide Produced by Plant-Derived <i>Lactobacillus plantarum</i> SN35N Exhibits Antiviral Activity	10
Pharmacology of Antagonism of GPCR	10
Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, a	10
Tapentadol in Cancer Patients with Neuropathic Pain: A Comparison of Methadone, Oxycodone, Fentanyl, and Hydromorphone	10
Androgen-Dependent Differences in the Amounts of <i>CYP</i> mRNAs in the Pig Kidney	10
Improved Detection Sensitivity of an Antigen Test for SARS-CoV-2 Nucleocapsid Proteins with Thio-NAD Cycling	10
Detection Method of Falsified Medicines by Using a Low-Cost Raman Scattering Spectrometer Combined with Soft Independent Modeling of Class Analogy and Partial Least Squares Discriminant Analysis	9
Lag Time for New Innovative, First-in-Class, Drug Approval in Japan	9
Dexmedetomidine Reduces the Lidocaine-Induced Neurotoxicity by Inhibiting Inflammasome Activation and Reducing Pyroptosis in Rats	9
Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice	9

Acute Ramelteon Treatment Maintains the Cardiac Rhythms of Rats during Non-REM Sleep	9
Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice	9
Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Indivi	9
Transient ETV2 Expression Promotes the Generation of Mature Endothelial Cells from Human Pluripotent Stem Cells	9
Accumulation of Toxic Advanced Glycation End-Products Induces Cytotoxicity and Inflammation in Hepatocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells	9
Trends Associated with Hemorrhoids in Japan: Data Mining of Medical Information Datasets and the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) Open Data Japa	9
The Light-Inducible Genes <i>Per2</i>, <i>Cry1a</i>, and <i>Cry2a</i> Regulate Oxidative Status in Zebrafish	9
The Japanese Herbal (Kampo) Medicine Hochuekkito Attenuates Lung Inflammation in Lung Emphysema	9
Estrogen Receptor β as a Possible Double-Edged Sword Molecule in Breast Cancer: A Mechanism of Alteration of Its Role by Exposure to Endocrine-Disrupting Chemicals	9
The Many Roles of Lysophospholipid Mediators and Japanese Contributions to This Field	9
High-Dose Vitamin C Exerts Its Anti-cancer Effects in a Xenograft Model of Colon Cancer by Suppressing Angiogenesis	9
Vitexin Attenuates Non-alcoholic Fatty Liver Disease Lipid Accumulation in High Fat-Diet Fed Mice by Activating Autophagy and Reducing Endoplasmic Reticulum Stress in Liver	9
Development of an SS-Cleavable pH-Activated Lipid-Like Material (ssPalm) as a Nucleic Acid Delivery Device	9
Safety and Biocompatibility of Mupirocin Nanoparticle-Loaded Hydrogel on Burn Wound in Rat Model	8
Topical Xerostomia Treatment with Hyaluronate Sheets Containing Pilocarpine	8
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells	8
Macrophage Response Driven by Extracellular ATP	8
Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity	8
Inhibition of Stearoyl-CoA Desaturase 1 Potentiates Anti-tumor Activity of Amodiaquine in Non-small Cell Lung Cancer	8
Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells	8
Andrographolide/Phospholipid/Cyclodextrin Complex-Loaded Nanoemulsion: Preparation, Optimization, <i>in Vitro</i> and <i>in Vivo</i> Evaluation	8
Different Renal Chronotoxicity of Bromobenzene and Its Intermediate Metabolites in Mice	8
Quantitative Proteomics-Based Blood–Brain Barrier Study	8
Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1	8
Simultaneous Screening of SARS-CoV-2 Omicron and Delta Variants Using High-Resolution Melting Analysis	8
Target Therapeutic Ranges of Anti-MRSA Drugs, Linezolid, Tedizolid and Daptomycin, and the Necessity of TDM	8
Curculigoside Represses the Proliferation and Metastasis of Osteosarcoma <i>via</i> the JAK/STAT and NF-κB Signaling Pathways	8
Linarin Protects the Kidney against Ischemia/Reperfusion Injury <i>via</i> the Inhibition of Bioactive ETS2/IL-12	8
Safety of Remdesivir in 20 Children with COVID-19—Case Series—	8
Emodin Suppresses the Migration and Invasion of Melanoma Cells	8
Berberine Encapsulated in Exosomes Derived from Platelet-Rich Plasma Promotes Chondrogenic Differentiation of the Bone Marrow Mesenchymal Stem Cells <i>via</i> the Wnt/β-Catenin Pathway	8
Effect of <i>N</i>-Acetyl Cysteine on Renal Interstitial Fibrosis in Mice	8
Yi-Zhi-Fang-Dai Formula Exerts a Protective Effect on the Injury of Tight Junction Scaffold Proteins <i>in Vitro</i> and <i>in Vivo</i> by Mediating Autophagy through Regulatio	8
Dexmedetomidine relieved neuropathic pain and inflammation response induced by CCI through HMGB1/TLR4/NF-κB signal pathway	8
Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury <i>via</i> Suppression of Macrophage Involved Inflammation	8
Effect of Ginsenoside Rb2 on a Myocardial Cell Model of Coronary Heart Disease through Nrf2/HO-1 Signaling Pathway	8
Evaluation of the Estrogenic Action Potential of Royal Jelly by Genomic Signaling Pathway <i>in Vitro</i> and <i>in Vivo</i>	8
Down-Regulation of Ubiquitin-Specific Peptidase 9X Inhibited Proliferation, Migration and Invasion of Osteosarcoma <i>via</i> ERK1/2 and PI3K/Akt Signaling Pathways	8
Methylglyoxal-Derived Advanced Glycation End Products (AGE4) Promote Cell Proliferation and Survival in Renal Cell Carcinoma Cells through the RAGE/Akt/ERK Signaling Pathways	8
PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from <i>Eclipta prostrata</i> L.	7
Sex, Organ, and Breed Differences in the mRNA Expression of Drug Transporters in the Liver and Kidney of Pigs	7
<i>N</i>,<i>N</i>′-1,10-Bis(Naringin) Triethylenetetraamine, Synthesis and as a Cu(II) Chelator for Alzheimer’s Disease Therapy	7
Synthesis and Biological Evaluation of Salicylic Acid Analogues of Celecoxib as a New Class of Selective Cyclooxygenase-1 Inhibitor	7
Hesperidin Inhibits UVB-Induced VEGF Production and Angiogenesis <i>via</i> the Inhibition of PI3K/Akt Pathway in HR-1 Hairless Mice	7
Deletion of TRPC3 or TRPC6 Fails to Attenuate the Formation of Inflammation and Fibrosis in Non-alcoholic Steatohepatitis	7
Total Saponins from <i>Paris forrestii</i> Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp <i>via</i> ERK Signaling Pathway	7
Artesunate Inhibits Apoptosis and Promotes Survival in Schwann Cells <i>via</i> the PI3K/AKT/mTOR Axis in Diabetic Peripheral Neuropathy	7
Health Effects and Safety Assurance of Nanoparticles in Vulnerable Generations	7
<i>Polygonatum sibiricum</i> Polysaccharide Inhibited Liver Cancer in a Simulated Tumor Microenvironment by Eliminating TLR4/STAT3 Pathway	7
Pharmaceutical Care Contributes to the Advanced Management of Patients Receiving Immune Checkpoint Inhibitors	7
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells <i>via</i> ROS Production and PI3K/AKT Pathway Inhibition	7
Comparison of the Safety and Effectiveness of Four Direct Oral Anticoagulants in Japanese Patients with Nonvalvular Atrial Fibrillation Using Real-World Data	7
PI3K/AKT1 Signaling Pathway Mediates Sinomenine-Induced Hepatocellular Carcinoma Cells Apoptosis: An <i>in Vitro</i> and <i>in Vivo</i> Study	7
Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin	7
Role of Mitochondrial Dysfunction in the Pathogenesis of Cisplatin-Induced Myotube Atrophy	7
High-Dose Vitamin C Administration Inhibits the Invasion and Proliferation of Melanoma Cells in Mice Ovary	7
Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine	7
Evaluation of Agonistic Activity of Fluorinated and Nonfluorinated Fentanyl Analogs on μ-Opioid Receptor Using a Cell-Based Assay System	7
Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice	7
Dose Individualization of Oral Multi-Kinase Inhibitors for the Implementation of Therapeutic Drug Monitoring	7
Anti-allergic Inflammatory Components from the Leaves of <i>Piper crocatum</i> Ruiz & Pav.	7
NSC23766 and Ehop016 Suppress Herpes Simplex Virus-1 Replication by Inhibiting Rac1 Activity	7
3′,4′,7-Trihydroxyflavone Downregulates NO Production in LPS- or IFN-γ-Activated MG6 Microglial Cells by Attenuating the JNK–STAT1 Pathway	7
Nicotine Enhances Firing Activity of Layer 5 Pyramidal Neurons in the Medial Prefrontal Cortex through Inhibition of Kv7 Channels	7
Expression, Purification and Characterization of CAR/NCOA-1 Tethered Protein in <i>E. coli</i> Using Maltose-Binding Protein Fusion Tag and Gelatinized Corn Starch	7
Rivaroxaban Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Hypertension	7
Effects of Uremic Toxins on the Binding of Aripiprazole to Human Serum Albumin	6
Mesenchymal Stem Cells Alter the Inflammatory Response of C2C12 Mouse Skeletal Muscle Cells	6
Overexpressed Hsa_circ_0001326 Contributes to the Decreased Cell Viability in SWAN71 Cells by Regulating MiR-186-5p/p27 Kip1 Axis	6
<i>Astragalus</i> Polysaccharide Suppresses Cell Proliferation and Invasion by Up-Regulation of miR-195-5p in Non-small Cell Lung Cancer	6
Disproportionality Analysis of Safety Signals for a Wide Variety of Opioid-Related Adverse Events in Elderly Patients Using the Japanese Adverse Drug Event Report (JADER) Database	6
Topical Application of BMS-509744, a Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase, Ameliorates Imiquimod-Induced Skin Inflammation in Mice	6
Strengthening the Competitiveness of Japan’s Pharmaceutical Industry: Analysis of Country Differences in the Origin of New Drugs and Japan’s Highly Productive Firm	6
Onset Mechanism and Pharmaceutical Management of Dry Skin	6
KB-R7943 Inhibits the Mitochondrial Ca<sup>2+</sup> Uniporter but Not Na<sup>+</sup>–Ca<sup>2+</sup> Exchanger in Cardiomyocyte-Derived H9c2 Cells	6
Angiotensin (1–7) Attenuates the Nociceptive Behavior Induced by Substance P and NMDA <i>via</i> Spinal MAS1	6
<i>In Vitro</i> and <i>in Vivo</i> Comparative Study of Oral Nanoparticles and Gut Iontophoresis as Oral Delivery Systems for Insulin	6
Effects of Bepridil and Pimozide, Existing Medicines Capable of Blocking T-Type Ca<sup>2+</sup> Channels, on Visceral Pain in Mice	6
Panaxytriol Inhibits Lipopolysaccharide-Induced Microglia Activation in Brain Inflammation <i>in Vivo</i>	6
Diurnal Changes in Protein Expression at the Blood–Brain Barrier in Mice	6

LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance <i>via</i> Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes	6
Pyoluteorin Induces Apoptosis and Autophagy in NSCLC Cells	6
Comparison of the Stimulatory and Inhibitory Effects of Steroid Hormones and α-Naphthoflavone on Steroid Hormone Hydroxylation Catalyzed by Human Cytochrome P450 3A Subfamilies	6
Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells	6
Octa-arginine and Octa-lysine Promote Cell Adhesion through Heparan Sulfate Proteoglycans and Integrins	6
Hyodeoxycholic Acid (HDCA) Prevents Development of Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice: Possible Role of Synergism between DSS and HDCA in Increasing Fecal Bile Acid Levels	6
Establishment of Three Types of Immortalized Human Skin Stem Cell Lines Derived from the Single Donor	6
Clinical Aspects of Drug–Drug Interaction and Drug Nephrotoxicity at Renal Organic Cation Transporters 2 (OCT2) and Multidrug and Toxin Exclusion 1, and 2-K (MATE1/MATE2-K)	6
Development of a Competitive Enzyme-Linked Immunosorbent Assay for the Determination of Sunitinib Unaffected by Light-Induced Isomerization	6
PC3-Secreted Microprotein Is Expressed in Glioblastoma Stem-Like Cells and Human Glioma Tissues	6
A Radiolabeled Self-assembled Nanoparticle Probe for Diagnosis of Lung-Metastatic Melanoma	6
Low Expression of Rasal2 Promotes Non-small Cell Lung Cancer Metastasis through Ras/ERK Pathway	6
Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange S	6
Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma	6
Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices	6
The Role of Potassium Channels in Chronic Stress-Induced Brain Injury	6
Acetaminophen Exerts an Analgesic Effect on Muscular Hyperalgesia in Repeated Cold-Stressed Rats through the Enhancement of the Descending Pain Inhibitory System Involving Spinal 5-HT<sub>3</	6
LncRNA Snhg5 Attenuates Status Epilepticus Induced Inflammation through Regulating NF-κΒ Signaling Pathway	6
Machine Learning-Based Model for Estimating Vancomycin Maintenance Dose to Target the Area under the Concentration Curve of 400–600 mg·h/L in Japanese Patients	6
Functional Alterations of Multidrug Resistance-Associated Proteins 2 and 5, and Breast Cancer Resistance Protein upon Snail-Induced Epithelial–Mesenchymal Transition in HCC827 Cells	6
Infliximab Treatment Persistence among Japanese Patients with Chronic Inflammatory Diseases: A Retrospective Japanese Claims Data Study	6
Proton Pumping ATPases: Rotational Catalysis, Physiological Roles in Oral Pathogenic Bacteria, and Inhibitors	5
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) Targets Estrogen Receptor β, to Evoke the Resistance of Human Breast Cancer MCF-7 Cells to G-1, an Agonist for G Protein-Coupled Estrogen Receptor 1	5
Hsa_circ_0002060 Knockdown Ameliorates Osteoporosis by Targeting MiR-198-5p	5
Candidone Inhibits Migration and Invasion, and Induces Apoptosis in HepG2 Cells	5
Cytotoxic Effects of Water-Soluble Extracts of Coarse and Fine Atmospheric Particulate Matter on Mast Cell Lines	5
Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice	5
Study on Catalpol Content in <i>Rehmannia glutinosa</i> Root, an Important Ingredient in Kampo Prescriptions	5
Temozolomide Induces Endocytosis of EGFRvIII <i>via</i> p38-Mediated Non-canonical Phosphorylation in Glioblastoma Cells	5
Cathepsin G-Induced Cell Aggregation of Breast Cancer MCF-7 Decreases Doxorubicin Sensitivity in a Hypoxia-Inducible Factor-Independent Mechanism	5
Calycosin may Alleviate Ang II-Induced Pro-proliferative Effects on Glomerular Mesangial Cells <i>via</i> Partially Inhibiting Autophagy and ERK Signaling Pathway	5
Effects of Josamycin on Scratching Behavior in NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions	5
Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy <i>via</i> Inhibiting Apoptosis and NLRP3 Inflammasome Activation	5
Targeting the Oxytocin System to Ameliorate Early Life Depressive-Like Behaviors in Maternally-Separated Rats	5
Pharmaceutical Technology Innovation Strategy Based on the Function of Blood Transport Proteins as DDS Carriers for the Treatment of Intractable Disorders and Cancer	5
Prediction of Human Pharmacokinetics Profile of Monoclonal Antibody Using hFcRn Transgenic Mouse Model	5
Genipin Attenuates Sepsis-Induced Splenocyte Apoptosis <i>via</i> the Inhibition of Endoplasmic Reticulum Stress	5
CRISPR-Cas9-Edited <i>SNCA</i> Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity	5
Mechanotransduction-Targeting Drugs Attenuate Stiffness-Induced Hepatic Stellate Cell Activation <i>in Vitro</i>	5
The Ethyl Acetate Subfraction of <i>Polygonum cuspidatum</i> Root Containing Emodin Affect EBV Gene Expression and Induce EBV-Positive Cells Apoptosis	5
A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production	5
Inhibitory Effect of a Late Sodium Current Blocker, NCC-3902, on the Automaticity of the Guinea Pig Pulmonary Vein Myocardium	5
Possible Therapeutic Applications of Targeting STAP Proteins in Cancer	5
Classification of Skin Injury Risk Caused by Extravasation of Electrolyte Solutions or Infusions in a Rat Model	5
Effective Anticancer Therapy by Combination of Nanoparticles Encapsulating Chemotherapeutic Agents and Weak Electric Current	5
Prostacyclin Synthase as an Ambivalent Regulator of Inflammatory Reactions	5
Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation	5
Radiosynthesis and <i>in Vivo</i> and <i>ex Vivo</i> Evaluation of Isomeric [<sup>11</sup>C]methoxy Analogs of Nimesulide as Brain Cyclooxygenase-2-Targeted Imaging	5
Indomethacin, a Non-steroidal Anti-inflammatory Drug, Induces Skin Dryness <i>via</i> PPARγ in Mice	5
Tranexamic Acid Improves the Disrupted Formation of Collagen and Fibrillin-1 Fibers Produced by Fibroblasts Repetitively Irradiated with UVA	5
Pharmacokinetic and Adsorptive Analyses of Administration of Oral Voriconazole Suspension <i>via</i> Enteral Feeding Tube in Intensive Care Unit Patients	5
Effects of Simulated Weightlessness on Metabolizing Enzymes and Pharmacokinetics of Folic Acid in SD Rats	5
Evaluation of Methods to Assess CYP3A Induction Risk in Clinical Practice Using <i>in Vitro</i> Induction Parameters	5
Anti-inflammatory Effects of Sanhuang-Siwu-Tang in Lipopolysaccharide-Stimulated RAW264.7 Macrophages and BV2 Microglial Cells	5
Analgesic Effects of Sokeikakketsuto on Chemotherapy-Induced Mechanical Allodynia and Cold Hyperalgesia in Rats	5
The Carboxyl-Terminal Penta-Peptide Repeats of Major Royal Jelly Protein 3 Enhance Cell Proliferation	5
The C-Terminal Penta-Peptide Repeats of Major Royal Jelly Protein 3 Ameliorate the Progression of Inflammation <i>in Vivo</i> and <i>in Vitro</i>	5
Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases	5
Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for the Treatment or Prevention of Alcoholic Liver Disease	5
Estimation of the Viscosity of an Antibody Solution from the Diffusion Interaction Parameter	5
Inflammation-Induced Attenuation of Prostaglandin D<sub>2</sub> Elimination across Rat Blood–Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug R	5
Calcium Peroxide-Containing Polydimethylsiloxane-Based Microwells for Inhibiting Cell Death in Spheroids through Improved Oxygen Supply	5
Antidepressant Effect of Intracerebroventricularly Administered Deltorphin Analogs in the Mouse Tail Suspension Test	5
Role of Epoxyeicosatrienoic Acids in Acetylcholine-Induced Dilation of Rat Retinal Arterioles <i>in Vivo</i>	5
Cold-Restraint Stress-Induced Ultrasonic Vocalization as a Novel Tool to Measure Anxiety in Mice	5
The Antimicrobial Peptide Esculentin-1a(1–21)NH<sub>2</sub> Stimulates Wound Healing by Promoting Angiogenesis through the PI3K/AKT Pathway	5
Chemical Activation of Piezo1 Alters Biomechanical Behaviors toward Relaxation of Cultured Airway Smooth Muscle Cells	5
Suppression of Hepatic Stellate Cell Death by Toxic Advanced Glycation End-Products	5
Riluzole Promotes Neurite Growth in Rats after Spinal Cord Injury through the GSK-3β/CRMP-2 Pathway	5
Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1	5
Effect of Itraconazole and Its Metabolite Hydroxyitraconazole on the Blood Concentrations of Cyclosporine and Tacrolimus in Lung Transplant Recipients	5
Inhibitory Effects of Vitamin A and Its Derivatives on Cancer Cell Growth Not Mediated by Retinoic Acid Receptors	5
Possible Involvement of DNA Methylation and Protective Effect of Zebularine on Neuronal Cell Death after Glutamate Excitotoxity	5
Risk Analysis of Denosumab-Induced Hypocalcemia in Bone Metastasis Treatment: Renal Dysfunction Is Not a Risk Factor for Its Incidence in a Strict Denosumab Administration Management System with Calci	5
Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of <i>in Silico</i> Liver-to-Plasma Partition Coefficients	5
Transforming Growth Factor-β1 and Bone Morphogenetic Protein-2 Inhibit Differentiation into Mature Ependymal Multiciliated Cells	5
Imatinib Mesylate Exerted Antitumor Effect by Promoting Infiltration of Effector T Cells in Tumor	4
<i>Nmu</i>/<i>Nms</i>/<i>Gpr176</i> Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity	4
Bisdemethoxycurcumin Inhibits VEGF-Induced HUVECs Proliferation, Migration and Invasion through AMPK/mTOR Pathway-Dependent Autophagy Activation and Cell Cycle Arrest	4
Disulfiram Synergizes with SRC Inhibitors to Suppress the Growth of Pancreatic Ductal Adenocarcinoma Cells <i>in Vitro</i> and <i>in Vivo</i>	4
Juzentaihoto Suppresses Muscle Atrophy in KKAy Mice	4
Antiplatelet Effect of Mirtazapine <i>via</i> Co-blocking of the 5-HT<sub>2A</sub> and α<sub>2</sub>-Adrenergic Receptors on Platelets	4
Pharmacokinetic Variability of Caffeine in Routinely Treated Preterm Infants: Preliminary Considerations on Developmental Changes of Systemic Clearance	4
The Regulation Pathway of VEGF Gene Expression Is Different between 2D Cells and 3D Spheroids in Human Lung Cancer Cells	4
GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast Cancer Progression by Inducing Cell Proliferation, Migration and Invasion, and Activating the NF-κB Signaling Pathway	4
A Methoxyflavanone from <i>Perilla frutescens</i> Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells	4
The Role of SGLT2 Inhibitor Ipragliflozin on Cardiac Hypertrophy and microRNA Expression Profiles in a Non-diabetic Rat Model of Cardiomyopathy	4
Dectin-1 Reactivity to Paramylon Derived from <i>Euglena gracilis</i> EOD-1	4
Geriatric Patients Are at a High Risk of Hypokalemia Associated with Yokukansan Preparation: A Retrospective Cohort Study	4
Safety Evaluation of Initial CT-P6 Administration for 30 min during the Switch from Reference Trastuzumab in Maintenance Infusion: A Multicenter Observational Study	4
A Novel Lithocholic Acid Derivative Upregulates Detoxification-Related Genes in Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids	4
Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin	4
Difference in Cost-Effectiveness between First-Line and Third-Line or Later Nivolumab Therapy in Patients with HER2-Negative, Unresectable, Advanced or Recurrent Gastric or Gastro-Esophageal Junction	4
Construction of a Risk Prediction Model of Extended Release Oxycodone Tablet-Induced Nausea and Clarification of Predictive Factors	4
The Enhancing Effects of <i>S</i>-Allylcysteine on Liver Regeneration Are Associated with Increased Expression of mRNAs Encoding IGF-1 and Its Receptor in Two-Thirds Partially Hepatectomiz	4