OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Clinical Biochemistry and Nutrition is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
TRIM62 knockdown by inhibiting the TLR4/NF-κB pathway and NLRP3 inflammasome attenuates cognitive impairment induced by diabetes in mice	37
A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study	26
The accumulation of copper in the brain of Down syndrome promotes oxidative stress: possible mechanism underlying cognitive impairment	20
Characterization of the gut phageome of Japanese patients with ulcerative colitis under endoscopic remission	18
Development of sandwich ELISAs for detecting glucagon-like peptide-1 secretion from intestinal L-cells and their application in STC-1 cells and mice	16
25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification	15
Quenching effect of cerium oxide nanoparticles on singlet oxygen: validation of the potential for reaction with multiple reactive oxygen species	15
Sirtuin 3 ameliorates inflammatory bowel disease via inhibiting intestinal inflammation and oxidative stress	13
Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients	12
The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease	12
The hypotaurine-taurine pathway as an antioxidative mechanism in patients with acute liver failure	12
Induction of <i>MYCN</i>-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist	11
Effect of folic acid supplementation on the change of plasma <i>S</i>-adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial	11
Relationships between body mass index and constipation, gastroesophageal reflux disease, stool forms based on the Bristol Stool Form Scale, and education level: results from an internet survey in Japa	11
Nobiletin, a polymethoxylated flavonoid from citrus, enhances IL-4 production in DO11.10 mice via antigen-presenting cells	10
Changes in plasma-concentration ratios of branched-chain amino acids in acute and convalescent phases of bacterial pneumonia	10
8-Prenylnaringenin suppresses obesity in high-fat diet-fed C57BL/6J mice via adiponectin secretion	9
Newly developed evaluation for intestinal permeability using <i>Caenorhabditis elegans</i>: protective effects of agaro-oligosaccharides on ‍intestinal permeability	9
Comparison of the oxidative profiles before and after revascularization in peripheral arterial disease: a pilot study	9
Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway	9
Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated	9
Association of alcohol intake and female gender with high expression of TMPRSS2 in tongue as potential risk for SARS-CoV-2 infection	9
A mixed antioxidant supplement improves cognitive function, and coordination in aged mice	8
Linear association between aging and decreased blood thiol antioxidant activity in patients with cataract	8
Gut dysbiosis induced by a high-salt diet aggravates atherosclerosis by increasing the absorption of saturated fatty acids in ApoE-deficient mice	8

Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients	8
LC/MS/MS detection of uric acid oxidation metabolites to evaluate reactive oxygen and nitrogen species <i>in vivo</i> with application to pseudo-inflammation	8
Fat-free oral nutritional supplements for patients after acute illness: a prospective observational study	8
Singlet oxygen from endoperoxide initiates an intracellular reactive oxygen species release in HaCaT keratinocytes	8
A nutritional intervention that promotes increased vegetable intake in Japanese with non-alcoholic fatty liver disease: a six-month trial	8
Coenzyme Q10 levels increase with embryonic development in medaka	7
Stimulatory effects of collagen production induced by coenzyme Q<sub>10</sub> in cultured skin fibroblasts	7
Twendee X, a mixed antioxidant supplement, improves cognitive function, coordination, and neurotrophic factor expression in long-term vitamin E-deficient mice	7
Intragastric bacterial infection and endoscopic findings in <i>Helicobacter pylori</i>-negative patients	7
GPRC5A regulates proliferation and oxidative stress by inhibiting the STAT3/Socs3/c-‍MYC pathway in hepatocellular carcinoma	7
Analysis of serum zinc level in patients with severe trauma	7
Treatment with broad-spectrum antibiotics upregulates Sglt1 and induces small intestinal villous hyperplasia in mice	7
Relative low muscle mass and muscle strength is associated with the prevalence of metabolic syndrome in patients with type 2 diabetes	7
Poricoic acid a inhibits mitochondrial dysfunction in myocardial infarction by activating SIRT3	7
Edaravone, a scavenger for multiple reactive oxygen species, reacts with singlet oxygen to yield 2-oxo-3-(phenylhydrazono)-butanoic acid	6
Copper in the tumor microenvironment and tumor metastasis	6
Enhancement of cytotoxic effects with ALA-PDT on treatment of radioresistant cancer cells	6
Reduced prosaposin levels in HepG2 cells with long-term coenzyme Q10 deficiency	6
Involvement of α-klotho in growth hormone (GH) signaling	6
HIF1α/CCL7/KIAA1199 axis mediates hypoxia-induced gastric cancer aggravation and glycolysis alteration	6
NEK7 inhibition attenuates Aβ<sub>42</sub>-induced cognitive impairment by regulating TLR4/NF-κB and the NLRP3 inflammasome in mice	6
Inhibition of ALA dehydratase activity in heme biosynthesis reduces cytoglobin expression which is related to the proliferation and viability of keloid fibroblasts	6
Modulations of the mTORC2–GATA3 axis by ‍an ‍isorhamnetin activated endosomal–lysosomal system of the J774.1 macrophage-like cell line	6
Evaluation of malnutrition by objective nutritional indexes and predictors in hospitalized patients with COVID-19	5
High poly-γ-glutamic acid-containing natto improves lipid metabolism and alters intestinal microbiota in mice fed a high-fat diet	5
Effects of ergothioneine on oxidative DNA damage and immune response induced by circadian rhythm disturbance in mice	5
Optimizing vitamin supplementation via reference interval update of vitamins A, E, B1, and B6 using HPLC	5
Adiponectin inhibits chemokine-induced cell migration via direct interaction with platelet factor 4	5
Background factors of idiopathic peptic ulcers and optimal treatment methods: a multicenter retrospective Japanese study	5
Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment	5
Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy	5
Dietary antioxidants and flavonoids intake, and their association with inflammation and oxidative stress parameters in asthmatic women: a case-control study	5
Imaging analysis for multiple paramagnetic agents using OMRI and electrophoresis	5
Sanguinarine attenuates hypoxia/reoxygenation-triggered H9c2 cell injury through activation of the Nrf2/NLRP3 pathway	5
Association between upper limb muscle quality and knee osteoarthritis in dynapenia: an observational cross-sectional study	5
FOXM1 transcriptionally activates NEIL3 to inhibit ferroptosis in lung adenocarcinoma cells	5
Reducing early pregnancy loss with vitamin D<sub>3</sub>: an analysis of serum 1,25-(OH)D<sub>3</sub> modulation and miscarriage risk	5
Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1α in mouse soleus muscles	4
Increasing trend of <i>Helicobacter pylori</i>-uninfected gastric cancer without gastric atrophy	4
Iron as spirit of life to share under monopoly	4
Redox state as assessed using the measurement of human non-mercaptalbumin in embryo culture media is associated with successful embryo development in human <i>in vitro</i> fertilization	4
Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-‍L1 expression level reflects tumor resistance	4
Crosstalk of copper and zinc in the pathogenesis of vascular dementia	4
3-(4-Hydroxy-3-methoxyphenyl) propionic acid mitigates dexamethasone-induced muscle atrophy by attenuating Atrogin-1 and MuRF-1 expression in mouse C2C12 skeletal myotubes	4
Relationship between serum pyridoxal 5'-‍phosphate concentration and cognitive function in older Japanese	4
Acute effect of fructose, sucrose, and isomaltulose on uric acid metabolism in healthy participants	4
Introduction to serial reviews: Copper biology in health and disease	4
Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and ‍reduction of trans-epidermal water loss: a ‍randomized, double-blind, and	4
Improvement trend for individual health guidance intervention according to Japan clinical guidelines by public health nurses for type 2 diabetes mellitus who visited for medical checkups regularly: a	4
A questionnaire-based survey on the etiopathogenesis of chronic constipation during a medical check-up in Japan	4

Knockdown of LRRK2 inhibits the progression of lung cancer by regulating TLR4/NF-κB pathways and NLRP3 inflammasome	4
The association between serum zinc level and clinical features in patients with inflammatory bowel disease	4
Effective disruption of cancer cell membranes by photodynamic therapy with cell membrane-adhesive photosensitizer	4
Effects of luseogliflozin treatment on hyperglycemia-induced muscle atrophy in rats	4
Andrographolide derivative CX-10 alleviates ulcerative colitis by modulating autophagy and cellular stress	4
Protective effects of liposomes encapsulating ferulic acid against CCl<sub>4</sub>-induced oxidative liver damage <i>in vivo</i> rat model	4