OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Clinical Biochemistry and Nutrition is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Development of sandwich ELISAs for detecting glucagon-like peptide-1 secretion from intestinal L-cells and their application in STC-1 cells and mice	44
DNA-mediated ZNF649 downregulation modulates the Hedgehog signaling pathway to ‍reduce the sensitivity of gastric cardia cancer to ‍5-FU	25
TRIM62 knockdown by inhibiting the TLR4/NF-κB pathway and NLRP3 inflammasome attenuates cognitive impairment induced by diabetes in mice	23
Quenching effect of cerium oxide nanoparticles on singlet oxygen: validation of the potential for reaction with multiple reactive oxygen species	23
Characterization of the gut phageome of Japanese patients with ulcerative colitis under endoscopic remission	20
Association between dietary fiber intake and mortality in populations with accelerated biological aging: a study based on NHANES 1999–2018 data	19
Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients	17
Sirtuin 3 ameliorates inflammatory bowel disease via inhibiting intestinal inflammation and oxidative stress	16
Mechanism of enteral nutrition in regulating Tfh/Tfr immune imbalance in colorectal cancer via the TLR4 signaling pathway	16
A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study	15
Nobiletin, a polymethoxylated flavonoid from citrus, enhances IL-4 production in DO11.10 mice via antigen-presenting cells	15
Induction of <i>MYCN</i>-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist	15
Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated	14
Comparison of the oxidative profiles before and after revascularization in peripheral arterial disease: a pilot study	14
Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway	14
Relationships between body mass index and constipation, gastroesophageal reflux disease, stool forms based on the Bristol Stool Form Scale, and education level: results from an internet survey in Japa	13
Newly developed evaluation for intestinal permeability using <i>Caenorhabditis elegans</i>: protective effects of agaro-oligosaccharides on ‍intestinal permeability	13
LC/MS/MS detection of uric acid oxidation metabolites to evaluate reactive oxygen and nitrogen species <i>in vivo</i> with application to pseudo-inflammation	13
8-Prenylnaringenin suppresses obesity in high-fat diet-fed C57BL/6J mice via adiponectin secretion	13
Shear stress stimuli-induced erythrocytes’ mechanical damage, and its relation to erythrocytes’ membrane oxidation and cellular aging	12
Reactive oxygen species generation by photothermal effects of adhesive near-infrared agents on the plasma membrane	12
Fat-free oral nutritional supplements for patients after acute illness: a prospective observational study	11
Intragastric bacterial infection and endoscopic findings in <i>Helicobacter pylori</i>-negative patients	11
Gut dysbiosis induced by a high-salt diet aggravates atherosclerosis by increasing the absorption of saturated fatty acids in ApoE-deficient mice	11
Linear association between aging and decreased blood thiol antioxidant activity in patients with cataract	10

GPRC5A regulates proliferation and oxidative stress by inhibiting the STAT3/Socs3/c-‍MYC pathway in hepatocellular carcinoma	10
A mixed antioxidant supplement improves cognitive function, and coordination in aged mice	10
Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients	10
Analysis of serum zinc level in patients with severe trauma	9
NEK7 inhibition attenuates Aβ<sub>42</sub>-induced cognitive impairment by regulating TLR4/NF-κB and the NLRP3 inflammasome in mice	9
Poricoic acid a inhibits mitochondrial dysfunction in myocardial infarction by activating SIRT3	9
Twendee X, a mixed antioxidant supplement, improves cognitive function, coordination, and neurotrophic factor expression in long-term vitamin E-deficient mice	9
Enhancement of cytotoxic effects with ALA-PDT on treatment of radioresistant cancer cells	8
Association of serum vitamin D and serum vitamin C with the risk of melanoma among adults in the United States: a cross-sectional analysis of 2003–2006 and 2017–2018 NHANES data	8
The effects of lutein, zeaxanthin and anthocyanins supplementation on visual function and vision protection in healthy school-‍aged children: a single-center prospective randomized controlled study	8
Involvement of α-klotho in growth hormone (GH) signaling	8
Modulations of the mTORC2–GATA3 axis by ‍an ‍isorhamnetin activated endosomal–lysosomal system of the J774.1 macrophage-like cell line	8
Inhibition of ALA dehydratase activity in heme biosynthesis reduces cytoglobin expression which is related to the proliferation and viability of keloid fibroblasts	8
Background factors of idiopathic peptic ulcers and optimal treatment methods: a multicenter retrospective Japanese study	8
Adiponectin inhibits chemokine-induced cell migration via direct interaction with platelet factor 4	8
HIF1α/CCL7/KIAA1199 axis mediates hypoxia-induced gastric cancer aggravation and glycolysis alteration	8
Association between comprehensive dietary antioxidant index and stroke: mediating role of ‍oxidative stress	8
Evaluation of malnutrition by objective nutritional indexes and predictors in hospitalized patients with COVID-19	8
High poly-γ-glutamic acid-containing natto improves lipid metabolism and alters intestinal microbiota in mice fed a high-fat diet	7
Effects of ergothioneine on oxidative DNA damage and immune response induced by circadian rhythm disturbance in mice	7
Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and ‍reduction of trans-epidermal water loss: a ‍randomized, double-blind, and	7
Hypoglycemia and altered bile acid metabolism are linked to latent iron deficiency in young Japanese women	7
Association between upper limb muscle quality and knee osteoarthritis in dynapenia: an observational cross-sectional study	7
Reducing early pregnancy loss with vitamin D<sub>3</sub>: an analysis of serum 1,25-(OH)D<sub>3</sub> modulation and miscarriage risk	7
Lipoprotein(a): structural basis, bidirectional risk, and therapeutic frontiers	7
Sanguinarine attenuates hypoxia/reoxygenation-triggered H9c2 cell injury through activation of the Nrf2/NLRP3 pathway	7
Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment	7
FOXM1 transcriptionally activates NEIL3 to inhibit ferroptosis in lung adenocarcinoma cells	7
Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-‍L1 expression level reflects tumor resistance	6
Effects of luseogliflozin treatment on hyperglycemia-induced muscle atrophy in rats	6
Exploring the potential targets and molecular mechanisms of cordycepin against gastric cancer based on bioinformatics analysis and network pharmacology	6
<i>N</i>-oxide-based and trioxolane-based fluorescent probes for monitoring labile iron and labile heme: an update	6
Dietary antioxidants and flavonoids intake, and their association with inflammation and oxidative stress parameters in asthmatic women: a case-control study	6
Protective effects of liposomes encapsulating ferulic acid against CCl<sub>4</sub>-induced oxidative liver damage <i>in vivo</i> rat model	5
Knockdown of LRRK2 inhibits the progression of lung cancer by regulating TLR4/NF-κB pathways and NLRP3 inflammasome	5
Effects of body position on high-resolution manometry parameters and their correlations with symptoms	5
Mixed lesions in premalignant colorectal polyps	5
Acute effect of fructose, sucrose, and isomaltulose on uric acid metabolism in healthy participants	5
Comparative neuroprotective and antioxidant roles of vitamin E isoforms: a review	5
Andrographolide derivative CX-10 alleviates ulcerative colitis by modulating autophagy and cellular stress	5
The ratio of TG/CysC is a significant indicator of nephritis in children with IgA vasculitis	5
Relationship between serum pyridoxal 5'-‍phosphate concentration and cognitive function in older Japanese	5
Effect of fat ingestion on postprandial oxidative status in healthy young women: a pilot study	5
The association between serum zinc level and clinical features in patients with inflammatory bowel disease	5
Optimizing vitamin supplementation via reference interval update of vitamins A, E, B1, and B6 using HPLC	5
Improvement trend for individual health guidance intervention according to Japan clinical guidelines by public health nurses for type 2 diabetes mellitus who visited for medical checkups regularly: a	5
Effective disruption of cancer cell membranes by photodynamic therapy with cell membrane-adhesive photosensitizer	5
Reduced phase angle as a potential indicator of mild cognitive impairment	5
3-(4-Hydroxy-3-methoxyphenyl) propionic acid mitigates dexamethasone-induced muscle atrophy by attenuating Atrogin-1 and MuRF-1 expression in mouse C2C12 skeletal myotubes	5
Investigation of the relationship between colonoscopy insertion difficulty factors and endoscope shape using an endoscopic position detection unit	4

Relationship between critical care nutrition and post-intensive care syndrome in surviving ventilated patients with COVID-19: a multicenter prospective observational study	4
Ginsenoside RK1 inhibits microglial activation and ROS production and alleviates vascular dementia in rats	4
Evaluation of cold atmospheric pressure plasma irradiation of water as a method of singlet oxygen generation	4
Porphyromonas gingivalis lipopolysaccharide regulates cell proliferation, apoptosis, autophagy in esophageal squamous cell carcinoma via TLR4/MYD88/JNK pathway	4
Quality analysis of the clinical laboratory literature and its effectiveness on clinical quality improvement: a systematic review	4
A randomized, double-blinded study evaluating effect of matcha green tea on human fecal microbiota	4
Therapeutic potential of hydrogen-rich water (HRW) in oxidative stress-related diseases	4
Letter to the Editor: Increased uric acid levels following fructose consumption: a biochemical perspective	4
Vicious cycle of vitamin B<sub>1</sub> insufficiency and heart failure in cardiology outpatients	4
Acute effect of proprotein convertase subtilisin/kexin type 9 inhibitor on oxidized low-density lipoprotein and lipid profile in patients at cardiovascular risk	4
Unique and overlapping roles of NRF2 and NRF1 in transcriptional regulation	4
Short-term intake of delta-tocotrienol on lipid profiles in healthy subjects	4
β-Elemene inhibits adipogenesis in 3T3-L1 cells by regulating AMPK pathway	4
Influence of transarterial chemoembolization on serum opsonic activity in hepatocellular carcinoma measured by chemiluminescence	4
Response to the Letter	3
Anti-aging effects of glycyrrhizin via maintaining Klotho levels	3
5-<i>N</i>-Carboxyimino-6-aminopyrimidine-2,4(3<i>H</i>)-dione, a novel indicator for hypochlorite formation	3
Method for detecting CoQ10 incorporation in the mitochondrial respiratory chain supercomplex	3
Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI	3
Female patients with end-stage renal failure treated by hemodialysis had a low mortality rate and small patient number compared to male patients: 5-year follow-up study in Japan	3
National trends in hospitalizations for gastrointestinal bleeding in Japan	3
MiR-301b-3p targets and regulates EBF3 to impact the stem-like phenotype of breast cancer cells through glycolysis	3
Aging-related dysregulation of energy metabolism and mitochondrial dynamics in ‍microglia	3
Development of ratiometric sirtuin fluorescence probes via cleavage of a coumarin dye	3
Can bone mass measured via bioelectrical impedance analysis be used to diagnose sarcopenia?	3
Impact of cyanidin 3-<i>O</i>-glucoside on rat micro-and systemic circulation, possibly thorough angiogenesis	3
Effect of omega-3 fatty acids on sleep: a systematic review and meta-analysis of randomized controlled trials	3
Levosimendan alleviates myocardial ischemia-reperfusion injury by regulating mitochondrial autophagy through cGAS-STING signaling pathway	3
Controlling systemic disease from the gut: intestinal ROS as an upstream driver of systemic inflammation	3
Simple method for estimating low muscle mass in persons with bioelectrical impedance analysis measurement difficulties	3
Innovative novel candy made from a low-solubility amorphous material promotes saliva secretion: a randomized, double-blind, placebo-controlled crossover comparative trial	3
Miso, fermented soybean paste, suppresses high-fat/high-sucrose diet-induced muscle atrophy in mice	3
Interaction between inorganic phosphate concentration and glucose metabolism in mild refeeding syndrome model	3
Is nerve-directed stretching effective for improving of ankle joint flexibility and tissue stiffness in older men?	3
Antioxidant polymer nanoparticles ameliorate cancer cachexia via intestinal ROS scavenging	3
Heat-treated and/or lysozyme-treated <i>Enterococcus faecalis</i> (FK-23) improves the progression of renal disease in a unilateral ischemia-reperfusion injury rat model	3
High-fat diet causes mitochondrial damage and downregulation of mitofusin-2 and optic atrophy-1 in multiple organs	3
DNA methylation of CA10 regulates the ‍proliferation and metastasis of bladder cancer	2
Effectiveness of the serum ratio of L-cysteine to glutathione for the prediction of cardiovascular events	2
Homocysteine increases phosphorylation and aggregation of α-synuclein	2
Erratum	2
Availability of dietary secoisolariciresinol diglucoside on borderline blood cholesterol level in men: a randomized, parallel, controlled, double-blinded clinical trial	2
A newly developed solution for the preservation of short-chain fatty acids, bile acids, and microbiota in fecal specimens	2
Association of urinary 8-hydroxydeoxyguanosine level with arteriosclerosis-related factors in ‍healthy, urban residents aged ≥50 years in ‍Japan	2
Microglial inflammatory reactions regulated by oxidative stress	2
Exploratory analysis of the association between dietary niacin intakes and nonalcoholic fatty liver disease among US adults: 1999–2018 data analysis from the National Health and Nutrition Examination	2
Characterized factors of subjects who were first time diagnosed as hyperglycemia more than 126 ‍mg/dl during annual or biannual medical checkups: a case-control study in Japan	2
Identification of miRNAs associated with eosinophilic esophagitis shown by esophageal mucosal biopsy results of Japanese patients	2
Caveolae and caveolin-1 as targets of dietary polyphenols for protection against vascular endothelial dysfunction	2
Regulating effect of serum selenium on diabetic kidney disease related all-cause mortality: evidence from NHANES database	2
Advances in reaction-based synthetic fluorescent probes for studying the role of zinc and copper ions in living systems	2
Slowly progressive cell death induced by GPx4-deficiency occurs via MEK1/ERK2 activation as a downstream signal after iron-independent lipid peroxidation	2
Chemical generation of superoxide in the co-presence of riboflavin derivatives and NADH: evidence for a non-enzymatic redox pathway	2
Metabolic mediators of the causal relationship between inflammatory bowel disease and allergic rhinitis: insights from Mendelian randomization	2
Combined fructose and sucrose consumption from an early age aggravates cardiac oxidative damage and causes a dilated cardiomyopathy in ‍SHR rats	2
Oral supplementation of a cell preparation of <i>Enterococcus faecalis</i> strain EC-12 stimulates superoxide dismutase production in the livers of healthy and arthritis-induced mice	2
SMOC2 promoted vascular smooth muscle cell proliferation, migration, and extracellular matrix degradation by activating BMP/TGF‐β1 signaling pathway	2
The role of senescence indicators in the linkage between high-glycemic food intake and lung cancer: a Mendelian randomization study	2
Micheliolide reduces the damage, pyroptosis and oxidative stress of cardiomyocytes caused by OGD/R by regulating the AMPK signaling pathway	2
Nutritional roles and therapeutic potentials of dietary sphingomyelin in brain diseases	2
Single oral administration of quercetin glycosides prevented acute hyperglycemia by ‍promoting GLUT4 translocation in skeletal muscles through the activation of AMPK in mice	2
The dose-response relationships of the direct scavenging activity of amide-based local anesthetics against multiple free radicals	2
The effect of SIRT1 knockdown on the gene expression of CoQ10 biosynthetic enzymes	2
Ethanol enhances selenoprotein P expression via ERK-FoxO3a axis in HepG2 cells	2
Sebacic acid, a royal jelly-containing fatty acid, decreases LPS-induced IL-6 mRNA expression in ‍differentiated human THP-1 macrophage-like cells	2
Mitochondrial oxidative stress, cellular damages and stem cell aging in premature aging models with complex II electron transport defect	2
Influence of vitamin D status on the variability of collagen I C-telopeptide in pre- and post-‍menopausal healthy women	2
Eurycomanone from <i>Eurycoma longifolia</i> Jack upregulates neurotrophin-3 gene expression in ‍retinal Müller cells <i>in vitro</i>	2
Inhibition of lincRNA-Cox2 alleviates apoptosis and inflammatory injury of lipopolysaccharide-stimulated human bronchial epithelial cells via the Nrf2/HO-1 axis	2
Dietary flaxseed oil suppresses hyperglycemia and hyperinsulinemia through increasing in α-linolenic acid content in the muscle	2
Vitamin D insufficiency and disease risk in the elderly	2
The revelation of UCHL1 in malignant epithelial cells of TNBC reinforcing cisplatin resistance by modulating ferroptosis based on single-cell transcriptome data	2