OOIR: Observatory of International Research

Papers

(The TQCC of Xenotransplantation is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months	79
Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies	42
Decellularized xenografts in regenerative medicine: From processing to clinical application	31
Genetically engineered pig kidney transplantation in a brain‐dead human subject	29
Factors influencing attitudes toward xenotransplantation clinical trials: A report of focus group studies	28
Physiological aspects of pig kidney xenotransplantation and implications for management following transplant	24
The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?	24
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation	23
Recent progress and remaining hurdles toward clinical xenotransplantation	22
Evidence suggesting that deletion of expression of N‐glycolylneuraminic acid (Neu5Gc) in the organ‐source pig is associated with increased antibody‐mediated rejection of kidney transplants in baboons	22
The porcine cytomegalovirus (PCMV) will not stop xenotransplantation	19
Long‐term porcine islet graft survival in diabetic non‐human primates treated with clinically available immunosuppressants	16
Commentary on achievement of first life‐saving xenoheart transplant	16
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models	15
Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?	15
Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation	14
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons	13
Experimental approach to nasal septal cartilage regeneration with adipose tissue‐derived stem cells and decellularized porcine septal cartilage	12
The attitudes of religious group leaders towards xenotransplantation: A focus group study	12
A perspective on the potential detrimental role of inflammation in pig orthotopic heart xenotransplantation	12
The problem of the “4th xenoantigen” after pig organ transplantation in non‐human primates may be overcome by expression of human “protective” proteins	12
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation	12
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood	11
Xenotransplantation of tannic acid‐encapsulated neonatal porcine islets decreases proinflammatory innate immune responses	11
World first pig‐to‐human cardiac xenotransplantation	11

Initial evidence that blockade of the CD40/CD154 costimulation pathway alone is sufficient as maintenance therapy in xenotransplantation	11
PCR and peptide based PCMV detection in pig – development and application of a combined testing procedure differentiating newly from latent infected pigs	11
Potential roles of mesenchymal stromal cells in islet allo‐ and xenotransplantation for type 1 diabetes mellitus	10
Attitudes of patients with renal disease on xenotransplantation: A systematic review	10
The first clinical trial—Kidney or heart?	10
The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic	10
Immunological selection and monitoring of patients undergoing pig kidney transplantation	10
Xenotransplantation: A historical–ethical account of viewpoints	9
Assessment of glomerular filtration and tubular secretion in baboons with life‐supporting pig kidney grafts	9
Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters	9
Coagulation, inflammation, and CD46 transgene expression in neonatal porcine islet xenotransplantation	9
Xenotransplantation of neonatal porcine bone marrow‐derived mesenchymal stem cells improves murine hind limb ischemia through lymphangiogenesis and angiogenesis	8
The case for the therapeutic use of mechanistic/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation	8
Xenotransplantation of neonatal porcine bone marrow–derived mesenchymal stem cells improves diabetic wound healing by promoting angiogenesis and lymphangiogenesis	8
Invited commentary: Initial reflections on the world's first clinical genetically‐engineered pig heart transplant	7
Early testing of porcine organ xenotransplantation products in humans: Microbial safety as illustrated for porcine cytomegalovirus	7
Pig‐to‐human kidney transplantation using brain‐dead donors as recipients: One giant leap, or only one small step for transplantkind?	7
The road to the first FDA‐approved genetically engineered pig heart transplantation into human	7
Lebanese medical students’ knowledge on and attitude toward xenotransplantation and its ethical issues: A cross‐sectional study	6
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo‐glycans	6
Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation	6
Anti‐thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival	6
Generating liver using blastocyst complementation: Opportunities and challenges	6
The effects of necrostatin‐1 on the in vitro development and function of young porcine islets over 14‐day prolonged tissue culture	6
Current state of clinical trials on xenograft	6
Mixed xenogeneic porcine chimerism tolerizes human anti‐pig natural antibody‐producing cells in a humanized mouse model	5
Opinions of nursing and theology faculty students on Xenotransplantation	5
Third update on possible animal sources for human COVID‐19	5
Mathieu Jaboulay's (1860–1913) contribution to xenotransplantation	5
First transplantation of a pig heart from a multiple gene‐modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs	5
Comparison of islet isolation result and clinical applicability according to GMP‐grade collagenase enzyme blend in adult porcine islet isolation and culture	5
Generation of glycans depleted decellularized porcine pericardium, using digestive enzymatic supplements and enzymatic mixtures for food industry	5
Knock‐out of N‐glycolylneuraminic acid attenuates antibody‐mediated rejection in xenogenically perfused porcine lungs	5
Porcine cytomegalovirus: A very unwelcome stowaway	4
High‐quality porcine islets isolated from aged miniature pigs	4
Detection of cell‐free pig DNA using integrated PERV sequences to monitor xenotransplant tissue damage and rejection	4
Patients’ opinions 10 years after receiving encapsulated porcine islet xenotransplantation without immunosuppression	4
Long‐term efficacy and safety of porcine islet macrobeads in nonimmunosuppressed diabetic cynomolgus macaques	4
An intrinsic link to an extrinsic cause of cardiac xenograft growth after xenotransplantation	4
Patient informed consent for a clinical trial of gene‐edited pig kidney transplantation: A representative consent form	4
Development and characterization of Gal KO porcine bone marrow‐derived mesenchymal stem cells	4
Acceptance of xenotransplantation by patients waiting for organ donation: A qualitative study	4
Human erythrocyte fragmentation during ex‐vivo pig organ perfusion	4
Development of a panel for detection of pathogens in xenotransplantation donor pigs	4
Peritoneal dissolved oxygen and function of encapsulated adult porcine islets transplanted in streptozotocin diabetic mice	4
Should you need an organ… Flemish secondary school students’ attitudes toward xenotransplantation and transgenetic organ donation	4
Recent progress in the pig‐to‐nonhuman primate kidney transplantation model: Report of a symposium	4
Genetic modifications designed for xenotransplantation attenuate sialoadhesin‐dependent binding of human erythrocytes to porcine macrophages	4