OOIR: Observatory of International Research

Papers

(The median citation count of Xenotransplantation is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
	101
Invited commentary	34
Systemic inflammation in the xenotransplant recipient (SIXR) can occur in the absence of pCMV infection	34
Transthoracic echocardiography is a simple tool for size matching in cardiac xenotransplantation	31
Hendrik Jan (Henk) Schuurman, MSc, PhD (1950–2024): In Memoriam	27
Bioinformatic analysis as a first step to predict the compatibility of hematopoiesis and immune system genes between humans and pigs	25
Anti‐pig antibodies in swine veterinarian serum: Implications for clinical xenotransplantation	19
Xenotransplantation of tannic acid‐encapsulated neonatal porcine islets decreases proinflammatory innate immune responses	19
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation	19
Xenotransplantation Literature Update July–December 2024	16
First transplantation of a pig heart from a multiple gene‐modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs	16
Human erythrocyte fragmentation during ex‐vivo pig organ perfusion	15
ECG Features in Orthotopic Cardiac Xenotransplantation: Comparisons With Published Literature	15
hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood	14
Issue Information	13
Xenotransplantation of neonatal porcine bone marrow‐derived mesenchymal stem cells improves murine hind limb ischemia through lymphangiogenesis and angiogenesis	13
Heterogenous expression of endocrine and progenitor cells within the neonatal porcine pancreatic lobes–Implications for neonatal porcine islet xenotransplantation	12
Xenotransplantation: A historical–ethical account of viewpoints	12
	12
Modified CD40L‐Activated B‐Cell Proliferation Model for Validating the Suppressive Activity of CD40‐CD154 Pathway Inhibitors	11
He reshaped the forefront of xenotransplantation: Agustin Pasqual Dalmasso (1933–2021)	11
The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats	11
Evidence suggesting that deletion of expression of N‐glycolylneuraminic acid (Neu5Gc) in the organ‐source pig is associated with increased antibody‐mediated rejection of kidney transplants in baboons	11
An ethical algorithm for xenotransplantation? Further transparency and clarity needed	11
Xenoreactive antibodies in α‐granules of human platelets bind pig liver endothelial cells	10

Porcine‐derived medical therapies for SARS‐CoV‐2: Traversing Muslim bioethical concerns and assuring equity	10
What does the PERV copy number tell us?	9
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons	9
Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation	9
Issue Information	8
Religion and Attitudes Toward Xenotransplantation: Results of a Nationwide Survey in the United States	8
Xenotransplantation Literature Update December 2023–June 2024	8
The case for the therapeutic use of mechanistic/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation	8
Organ xenotransplantation acceptance in veterinary students: A multicentric opinion study in Spain	7
Defect in Sensing Human Thrombin by Porcine Endothelial Protease‐Activated Receptor‐1: Molecular Incompatibility Between Porcine PAR‐1 and Human Thrombin	7
Announcement	7
Xenotransplantation in the Age of Genome Editing: Results From the Expert Report for the Federal Ethics Committee on Nonhuman Biotechnology With a Special Focus on Animal Ethics	7
Issue Information	7
Recent progress in the pig‐to‐nonhuman primate kidney transplantation model: Report of a symposium	7
Xenotransplantation of pig islet cells: Potential adverse impact of virus infections on their functionality and insulin production	7
Overcoming perioperative inflammation as a hurdle for successful preclinical orthotopic cardiac xenogeneic transplantations – particular in regard of the mandatory use of heart‐lung machines	7
Evaluation of Complement‐Dependent Cytotoxicity Assays for Gene‐Edited Pig‐to‐Human Xenotransplantation	7
Exploring attitudes toward xenotransplantation: A scoping review of healthcare workers, healthcare students, and kidney patients	6
Observations on hydronephrosis after pig kidney transplantation in baboons	6
Commentary on achievement of first life‐saving xenoheart transplant	6
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation	6
	6
A compositional analysis of native and decellularized porcine nasal septum cartilage	6
Genetic diversity, growth and heart function of Auckland Island pigs, a potential source for organ xenotransplantation	6
Antibodies against hyaluronan oligosaccharides in xenotransplantation	5
Historic progress in xenotransplantation with successful transplantation of genetically‐edited pig kidneys into living recipients	5
Xenotransplantation of neonatal porcine bone marrow–derived mesenchymal stem cells improves diabetic wound healing by promoting angiogenesis and lymphangiogenesis	5
Comparative Inhibitory Effects of Tacrolimus, Cyclosporine, and Rapamycin on Human Anti‐Pig Xenogeneic Mixed Lymphocyte Reactions	5
International Xenotransplantation Association (IXA) Position Paper on the History, Current Status, and Regulation of Xenotransplantation	5
Issue Information	5
Two‐day Static Cold Preservation of α1,3‐Galactosyltransferase Knockout Kidney Grafts Before Simulated Xenotransplantation	5
Cover image	5
Xenotransplantation, Ethics, and Pediatric Decedent Studies	5
The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic	5
Issue Information	5
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo‐glycans	4
Antibody‐mediated rejection in xenotransplantation: Can it be prevented or reversed?	4
	4
Generation of glycans depleted decellularized porcine pericardium, using digestive enzymatic supplements and enzymatic mixtures for food industry	4
The impact of IdeS (imlifidase) on allo‐specific, xeno‐reactive, and protective antibodies in a sensitized rhesus macaque model	4
Alteration of γδ T cell subsets in non‐human primates transplanted with GGTA1 gene‐deficient porcine blood vessels	4
In vivo induction of regulatory T cells by anti‐CD45RB antibody causes transferable tolerance to discordant human xenogenic islets	4
Large‐Scale Formation and Long‐Term Culture of Hepatocyte Organoids From Streamlined In Vivo Genome‐Edited GGTA1^−/− Pigs for Bioartificial Liver Applications	4
Asking the Right Questions: Larry Faucette's Journey Through Xenotransplant	4
In Memoriam – Guy Alexandre (1934–2024)	4
Sex Differences in Maturation and Function of Neonatal Porcine Islets Upon Transplantation in Mice	4
Xenotransplantation clinical trials: Should patients with diminished capacity be permitted to enroll?	3
How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs	3
Invited commentary: Initial reflections on the world's first clinical genetically‐engineered pig heart transplant	3
Issue Information	3

The birth of Dolly and xenotransplantation 25 years on	3
Updateon xenotransplantation for May/June 2021	3
	3
	3
Treatment of Presumptive Rejection After Orthotopic Pig‐to‐Baboon Cardiac Xenotransplantation	3
Long‐term efficacy and safety of porcine islet macrobeads in nonimmunosuppressed diabetic cynomolgus macaques	3
Use of Brain Death Recipients in Xenotransplantation: A Double‐Edged Sword	3
Long‐term control of diabetes by tofacitinib‐based immunosuppressive regimen after allo islet transplantation in diabetic rhesus monkeys that rejected previously transplanted porcine islets	3
	3
The International Human Xenotransplantation Inventory: Current Data and Future Directions	3
SARS‐CoV‐2 does not infect pigs, but this has to be verified regularly	3
Xenotransplantation at 30 years – A personal reminiscence and some thoughts for the future	2
Combinatorial Decellularization as a Better Approach to Porcine Liver Extracellular Matrix Scaffold Fabrication With Preserved Bioactivity: A Comparative Evaluation	2
Issue Information	2
International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation	2
Issue Information	2
Expert opinion on the identification, risk assessment, and mitigation of microorganisms and parasites relevant to xenotransplantation products from pigs	2
	2
Knock‐out of N‐glycolylneuraminic acid attenuates antibody‐mediated rejection in xenogenically perfused porcine lungs	2
Patient informed consent for a clinical trial of gene‐edited pig kidney transplantation: A representative consent form	2
Issue Information	2
Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants	2
Pig‐to‐human kidney transplantation using brain‐dead donors as recipients: One giant leap, or only one small step for transplantkind?	2
An IgM Cleaving Enzyme for Clearance of Anti‐Pig Xenoreactive Antibodies in a Nonhuman Primate Model	2
Xenotransplantation literature update March 2023–November 2023	2
The porcine cytomegalovirus (PCMV) will not stop xenotransplantation	2
Genetically engineered pig kidney transplantation in a brain‐dead human subject	2
Clinical cardiac xenotransplantation first in the clinical arena	2
In Memoriam: Sir Roy Calne, FRCS, FRS, 1930–2024	2
Bridging Therapies—Ex Vivo Liver Xenoperfusion and the Role of Machine Perfusion: An Update	2
Comparison of islet isolation result and clinical applicability according to GMP‐grade collagenase enzyme blend in adult porcine islet isolation and culture	2
Molecular incompatibility between pig CD200 and human CD200 receptor in in vitro xenogeneic immune responses	2
Anti–Non‐Gal Antibodies Against Porcine Protein Antigens as Barrier to Long‐Term Grafting of Xenografts in Humans	2
Non‐Classical Swine Leukocyte Antigens SLA‐6, ‐7, and ‐8, Are Xenoantigens for Some Waitlisted Patients	1
Assessment of glomerular filtration and tubular secretion in baboons with life‐supporting pig kidney grafts	1
Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A	1
Xenotransplantation in China: Past, Present, and Future	1
MRI monitoring of transplanted neonatal porcine islets labeled with polyvinylpyrrolidone‐coated superparamagnetic iron oxide nanoparticles in a mouse model	1
Novel factors potentially initiating acute antibody‐mediated rejection in pig kidney xenografts despite an efficient immunosuppressive regimen	1
Development and characterization of islet‐derived mesenchymal stem cells from clinical grade neonatal porcine cryopreserved islets	1
Attitudes Toward Renal Xenotransplantation in a Muslim Country: Analysis of Specific Subgroups	1
Xenogeneic Sertoli cells modulate immune response in an evolutionary distant mouse model through the production of interleukin‐10 and PD‐1 ligands expression	1
Iscalimab Combined With Transient Tesidolumab Prolongs Survival in Pig‐to‐Rhesus Monkey Renal Xenografts	1
Lessons learned from the first cardiac xenotransplant in a consciously consenting human: Psychiatric considerations and the impact of media exposure	1
Cover image	1
COVER IMAGE	1
Mathieu Jaboulay's (1860–1913) contribution to xenotransplantation	1
Evaluation of knowledge, attitude, and awareness of liver transplant patients toward xenotransplantation	1
The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?	1
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood	1
Issue Information	1
The attitudes of religious group leaders towards xenotransplantation: A focus group study	1
Cover image	1
Invited commentary	1
Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency	1
A murine groin site cardiac transplantation model—applicable tool for studying roles of peripheral lymph nodes in transplantation	1
Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?	1