OOIR: Observatory of International Research

Papers

(The median citation count of Xenotransplantation is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months	79
Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies	42
Decellularized xenografts in regenerative medicine: From processing to clinical application	31
Genetically engineered pig kidney transplantation in a brain‐dead human subject	29
Factors influencing attitudes toward xenotransplantation clinical trials: A report of focus group studies	28
Physiological aspects of pig kidney xenotransplantation and implications for management following transplant	24
The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?	24
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation	23
Recent progress and remaining hurdles toward clinical xenotransplantation	22
Evidence suggesting that deletion of expression of N‐glycolylneuraminic acid (Neu5Gc) in the organ‐source pig is associated with increased antibody‐mediated rejection of kidney transplants in baboons	22
The porcine cytomegalovirus (PCMV) will not stop xenotransplantation	19
Long‐term porcine islet graft survival in diabetic non‐human primates treated with clinically available immunosuppressants	16
Commentary on achievement of first life‐saving xenoheart transplant	16
Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?	15
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models	15
Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation	14
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons	13
The problem of the “4th xenoantigen” after pig organ transplantation in non‐human primates may be overcome by expression of human “protective” proteins	12
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation	12
Experimental approach to nasal septal cartilage regeneration with adipose tissue‐derived stem cells and decellularized porcine septal cartilage	12
The attitudes of religious group leaders towards xenotransplantation: A focus group study	12
A perspective on the potential detrimental role of inflammation in pig orthotopic heart xenotransplantation	12
Initial evidence that blockade of the CD40/CD154 costimulation pathway alone is sufficient as maintenance therapy in xenotransplantation	11
PCR and peptide based PCMV detection in pig – development and application of a combined testing procedure differentiating newly from latent infected pigs	11
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood	11

Xenotransplantation of tannic acid‐encapsulated neonatal porcine islets decreases proinflammatory innate immune responses	11
World first pig‐to‐human cardiac xenotransplantation	11
The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic	10
Immunological selection and monitoring of patients undergoing pig kidney transplantation	10
Potential roles of mesenchymal stromal cells in islet allo‐ and xenotransplantation for type 1 diabetes mellitus	10
Attitudes of patients with renal disease on xenotransplantation: A systematic review	10
The first clinical trial—Kidney or heart?	10
Assessment of glomerular filtration and tubular secretion in baboons with life‐supporting pig kidney grafts	9
Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters	9
Coagulation, inflammation, and CD46 transgene expression in neonatal porcine islet xenotransplantation	9
Xenotransplantation: A historical–ethical account of viewpoints	9
The case for the therapeutic use of mechanistic/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation	8
Xenotransplantation of neonatal porcine bone marrow–derived mesenchymal stem cells improves diabetic wound healing by promoting angiogenesis and lymphangiogenesis	8
Xenotransplantation of neonatal porcine bone marrow‐derived mesenchymal stem cells improves murine hind limb ischemia through lymphangiogenesis and angiogenesis	8
Pig‐to‐human kidney transplantation using brain‐dead donors as recipients: One giant leap, or only one small step for transplantkind?	7
The road to the first FDA‐approved genetically engineered pig heart transplantation into human	7
Invited commentary: Initial reflections on the world's first clinical genetically‐engineered pig heart transplant	7
Early testing of porcine organ xenotransplantation products in humans: Microbial safety as illustrated for porcine cytomegalovirus	7
Anti‐thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival	6
Generating liver using blastocyst complementation: Opportunities and challenges	6
The effects of necrostatin‐1 on the in vitro development and function of young porcine islets over 14‐day prolonged tissue culture	6
Current state of clinical trials on xenograft	6
Lebanese medical students’ knowledge on and attitude toward xenotransplantation and its ethical issues: A cross‐sectional study	6
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo‐glycans	6
Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation	6
Generation of glycans depleted decellularized porcine pericardium, using digestive enzymatic supplements and enzymatic mixtures for food industry	5
Knock‐out of N‐glycolylneuraminic acid attenuates antibody‐mediated rejection in xenogenically perfused porcine lungs	5
Mixed xenogeneic porcine chimerism tolerizes human anti‐pig natural antibody‐producing cells in a humanized mouse model	5
Opinions of nursing and theology faculty students on Xenotransplantation	5
Third update on possible animal sources for human COVID‐19	5
Mathieu Jaboulay's (1860–1913) contribution to xenotransplantation	5
First transplantation of a pig heart from a multiple gene‐modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs	5
Comparison of islet isolation result and clinical applicability according to GMP‐grade collagenase enzyme blend in adult porcine islet isolation and culture	5
Patient informed consent for a clinical trial of gene‐edited pig kidney transplantation: A representative consent form	4
Development and characterization of Gal KO porcine bone marrow‐derived mesenchymal stem cells	4
Acceptance of xenotransplantation by patients waiting for organ donation: A qualitative study	4
Human erythrocyte fragmentation during ex‐vivo pig organ perfusion	4
Development of a panel for detection of pathogens in xenotransplantation donor pigs	4
Peritoneal dissolved oxygen and function of encapsulated adult porcine islets transplanted in streptozotocin diabetic mice	4
Should you need an organ… Flemish secondary school students’ attitudes toward xenotransplantation and transgenetic organ donation	4
Recent progress in the pig‐to‐nonhuman primate kidney transplantation model: Report of a symposium	4
Genetic modifications designed for xenotransplantation attenuate sialoadhesin‐dependent binding of human erythrocytes to porcine macrophages	4
Porcine cytomegalovirus: A very unwelcome stowaway	4
High‐quality porcine islets isolated from aged miniature pigs	4
Detection of cell‐free pig DNA using integrated PERV sequences to monitor xenotransplant tissue damage and rejection	4
Patients’ opinions 10 years after receiving encapsulated porcine islet xenotransplantation without immunosuppression	4
Long‐term efficacy and safety of porcine islet macrobeads in nonimmunosuppressed diabetic cynomolgus macaques	4
An intrinsic link to an extrinsic cause of cardiac xenograft growth after xenotransplantation	4
Antibodies against hyaluronan oligosaccharides in xenotransplantation	3
Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants	3

Limited availability of methods for the detection of xenotransplantation‐relevant viruses in veterinary laboratories	3
Glycocalyx dynamics and the inflammatory response of genetically modified porcine endothelial cells	3
hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood	3
Expert opinion on the identification, risk assessment, and mitigation of microorganisms and parasites relevant to xenotransplantation products from pigs	3
Complement blockade with eculizumab to treat acute symptomatic humoral rejection after heart transplantation	3
Antibody‐mediated rejection in xenotransplantation: Can it be prevented or reversed?	3
Xenotransplantation Literature Update January/February 2021	3
In defense of xenotransplantation research: Because of, not in spite of, animal welfare concerns	3
Overcoming perioperative inflammation as a hurdle for successful preclinical orthotopic cardiac xenogeneic transplantations – particular in regard of the mandatory use of heart‐lung machines	3
Late graft failure of pig‐to‐rhesus renal xenografts has features of glomerulopathy and recipients have anti‐swine leukocyte antigen class I and class II antibodies	3
What is the clinical relevance of deviant serum calcium and phosphate levels after pig‐to‐primate kidney xenotransplantation?	3
Genetic diversity, growth and heart function of Auckland Island pigs, a potential source for organ xenotransplantation	2
Xenogeneic Sertoli cells modulate immune response in an evolutionary distant mouse model through the production of interleukin‐10 and PD‐1 ligands expression	2
A message from Mr. David Bennett Jr., the son of the first patient to receive a gene‐edited pig heart transplant	2
Xenotransplantation literature update March 2021–March 2023	2
Abstracts	2
Hemodynamics in pig‐to‐baboon heterotopic thoracic cardiac xenotransplantation: Recovery from perioperative cardiac xenograft dysfunction and impairment by cardiac overgrowth	2
Xenotransplantation literature update for September – October 2020	2
Pancreas preservation in extracellular‐type p38 inhibitor‐containing solution improves islet yield for porcine islet isolation	2
Incidence of serum antibodies to xenoantigens on triple‐knockout pig cells in different human groups	2
Comparison of methods for the detection of porcine cytomegalovirus/roseolovirus in relation to biosafety monitoring of xenotransplantation products	2
Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A	2
Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood	2
What does the PERV copy number tell us?	2
Deceased humans and living pigs as sources of kidneys for clinical transplantation—Can they be compared?	2
The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats	2
Characterisation of transgenic pigs expressing a human T cell‐depleting anti‐CD2 monoclonal antibody	2
Close contacts of xenograft recipients: Ethical considerations due to risk of xenozoonosis	2
Recellularized bovine pericardium with autologous mesenchymal stem cells reduces immune activation	2
Natural anti‐pig antibodies in infant baboons	2
Porcine‐derived medical therapies for SARS‐CoV‐2: Traversing Muslim bioethical concerns and assuring equity	2
SARS‐CoV‐2 does not infect pigs, but this has to be verified regularly	2
Specificity profile of αGal antibodies in αGalT KO mice as probed with comprehensive printed glycan array: Comparison with human anti‐Galili antibodies	2
The impact of IdeS (imlifidase) on allo‐specific, xeno‐reactive, and protective antibodies in a sensitized rhesus macaque model	2
Systemic inflammation in xenograft recipients (SIXR) or undetected PCMV/PRV transmission?	2
Transthoracic echocardiography is a simple tool for size matching in cardiac xenotransplantation	1
Increased human complement pathway regulatory protein gene dose is associated with increased endothelial expression and prolonged survival during ex‐vivo perfusion of GTKO pig lungs with human blood	1
Invited commentary	1
Observations on hydronephrosis after pig kidney transplantation in baboons	1
Xenotransplantation literature update, November/December 2020	1
Xenotransplantation clinical trials: Should patients with diminished capacity be permitted to enroll?	1
Advantages of the retroperitoneal retrocolic space as the transplant site for encapsulated xenogeneic islets	1
MRI monitoring of transplanted neonatal porcine islets labeled with polyvinylpyrrolidone‐coated superparamagnetic iron oxide nanoparticles in a mouse model	1
In vivo induction of regulatory T cells by anti‐CD45RB antibody causes transferable tolerance to discordant human xenogenic islets	1
Xenotransplantation literature update March 2023–November 2023	1
Limited environmental stability of infectious porcine endogenous retrovirus type C; Usage of reverse transcriptase in combination with viral RNA as markers for infectious virus	1
Invited commentary on “Deep Anterior lamellar keratoplasty with Cross‐linked Acellular Porcine Corneal Stroma to Manage Fungal Keratitis”	1
The Young Investigator Committee of the International Xenotransplantation Association—Perspective of advancements in the field in 2023	1
Large‐gap peripheral nerve repair using xenogeneic transplants in rhesus macaques	1
Pressing ethical issues relating to clinical pig organ transplantation studies	1
Bioinformatic analysis as a first step to predict the compatibility of hematopoiesis and immune system genes between humans and pigs	1
International Xenotransplantation Association (IXA) 25th anniversary	1
Xenotransplantation of pig islet cells: Potential adverse impact of virus infections on their functionality and insulin production	1
Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency	1
Modeling human anti‐pig xenoimmune responses in a pig artery tissue grafted humanized mouse model	1
Evaluation of knowledge, attitude, and awareness of liver transplant patients toward xenotransplantation	1
Open invitation to contribute ideas to a multifaceted approach to ethics in xenotransplantation	1
Generation and transplantation of hepatocytes‐like cells using human origin hepatogenic serum for acute liver injury treatment	1
Semi‐automated digital quantification of cellular infiltrates for in vivo evaluation of transplanted islets of Langerhans encapsulated with bioactive materials	1
Barriers toward xenotransplantation in Arab World	1
Systemic inflammation in the xenotransplant recipient (SIXR) can occur in the absence of pCMV infection	1
A compositional analysis of native and decellularized porcine nasal septum cartilage	1
Exploring attitudes toward xenotransplantation: A scoping review of healthcare workers, healthcare students, and kidney patients	1
Meeting report: Xenotransplantation Development Conference in Neijiang, China	1
Organ xenotransplantation acceptance in veterinary students: A multicentric opinion study in Spain	1
A study of knowledge and acceptance of kidney xenotransplantation among Chinese kidney transplant recipients and candidates	1
Improved osseointegration using porcine xenograft compared to demineralized bone matrix for the treatment of critical defects in a small animal model	1
Auxiliary liver xenotransplantation technique in a transgenic pig‐to‐non‐human primate model: A surgical approach to prolong survival	1
Emergence of novel circoviruses in humans and pigs and their possible importance for xenotransplantation and blood transfusions	1
Historic progress in xenotransplantation with successful transplantation of genetically‐edited pig kidneys into living recipients	1
Heterogenous expression of endocrine and progenitor cells within the neonatal porcine pancreatic lobes–Implications for neonatal porcine islet xenotransplantation	1
Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs	1