OOIR: Observatory of International Research

Papers

(The median citation count of Xenotransplantation is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months	63
Prevention of infection in xenotransplantation: Designated pathogen‐free swine in the safety equation	36
Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies	35
The final obstacle to successful pre‐clinical xenotransplantation?	33
Cold non‐ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig‐to‐baboon xenotransplantation	32
Coronavirus disease 2019 (COVID‐19) outbreak: Could pigs be vectors for human infections?	32
Genetically engineered pig kidney transplantation in a brain‐dead human subject	26
Factors influencing attitudes toward xenotransplantation clinical trials: A report of focus group studies	25
Sensitive detection systems for infectious agents in xenotransplantation*	23
The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?	22
Evidence suggesting that deletion of expression of N‐glycolylneuraminic acid (Neu5Gc) in the organ‐source pig is associated with increased antibody‐mediated rejection of kidney transplants in baboons	22
Decellularized xenografts in regenerative medicine: From processing to clinical application	22
Growth hormone receptor knockout: Relevance to xenotransplantation	21
Toward acellular xenogeneic heart valve prostheses: Histological and biomechanical characterization of decellularized and enzymatically deglycosylated porcine pulmonary heart valve matrices	21
Physiological aspects of pig kidney xenotransplantation and implications for management following transplant	20
The porcine cytomegalovirus (PCMV) will not stop xenotransplantation	19
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation	19
Recent progress and remaining hurdles toward clinical xenotransplantation	19
Bone xenotransplantation: A review of the history, orthopedic clinical literature, and a single‐center case series	17
Racial differences in attitudes to clinical pig organ Xenotransplantation	16
Long‐term follow‐up for the microbiological safety of clinical microencapsulated neonatal porcine islet transplantation	16
Commentary on achievement of first life‐saving xenoheart transplant	16
Xeno‐regenerative medicine: A novel concept for donor kidney fabrication	15
Long‐term porcine islet graft survival in diabetic non‐human primates treated with clinically available immunosuppressants	14
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models	13

Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?	13
Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation	12
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons	12
Initial evidence that blockade of the CD40/CD154 costimulation pathway alone is sufficient as maintenance therapy in xenotransplantation	11
Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons	11
How the COVID‐19 pandemic may impact public support for clinical xenotransplantation in the United States?	11
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation	11
The problem of the “4th xenoantigen” after pig organ transplantation in non‐human primates may be overcome by expression of human “protective” proteins	11
Recommendations to the IRB review process in preparation of xenotransplantation clinical trials	11
A perspective on the potential detrimental role of inflammation in pig orthotopic heart xenotransplantation	10
Challenges and practical realities of long‐term patient follow‐up in three xeno‐islet clinical trials: The experience in pig islet xenotransplantation trials in New Zealand and Argentina	10
Further information on possible animal sources for human COVID‐19	10
Solid organ xenotransplantation at the interface between research and clinical development: Regulatory aspects	10
Xenotransplantation of tannic acid‐encapsulated neonatal porcine islets decreases proinflammatory innate immune responses	10
Immunological selection and monitoring of patients undergoing pig kidney transplantation	9
Potential roles of mesenchymal stromal cells in islet allo‐ and xenotransplantation for type 1 diabetes mellitus	9
Update on possible animal sources for COVID‐19 in humans	9
World first pig‐to‐human cardiac xenotransplantation	9
The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic	9
The attitudes of religious group leaders towards xenotransplantation: A focus group study	9
Experimental approach to nasal septal cartilage regeneration with adipose tissue‐derived stem cells and decellularized porcine septal cartilage	9
Knowledge of and attitude toward xenotransplantation among medical students in China: A cross‐sectional study	9
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood	9
Assessment of glomerular filtration and tubular secretion in baboons with life‐supporting pig kidney grafts	8
Xenotransplantation of decellularized pig heart valves—Regulatory aspects in Europe	8
Coagulation, inflammation, and CD46 transgene expression in neonatal porcine islet xenotransplantation	8
Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters	8
Comparative study of impact of animal source on physical, structural, and biological properties of bone xenograft	8
The first clinical trial—Kidney or heart?	8
Xenogeneic mesenchymal stem cell transplantation for mandibular defect regeneration	7
Attitudes of patients with renal disease on xenotransplantation: A systematic review	7
Regulatory aspects of xenotransplantation in Korea	7
Xenotransplantation: A historical–ethical account of viewpoints	7
Xenotransplantation of neonatal porcine bone marrow‐derived mesenchymal stem cells improves murine hind limb ischemia through lymphangiogenesis and angiogenesis	7
Invited commentary: Initial reflections on the world's first clinical genetically‐engineered pig heart transplant	7
Deep anterior lamellar keratoplasty with cross‐linked acellular porcine corneal stroma to manage fungal keratitis	7
Solid‐phase silica‐based extraction leads to underestimation of residual DNA in decellularized tissues	7
The human T‐cell proliferative response to triple‐knockout pig cells in mixed lymphocyte reaction	6
Efficacy of ATG and Rituximab in capuchin monkeys (a New World monkey)–An in vitro study relevant to xenotransplantation	6
Regulatory changes in China on xenotransplantation and related products	6
Anti‐thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival	6
Early testing of porcine organ xenotransplantation products in humans: Microbial safety as illustrated for porcine cytomegalovirus	6
Partnership of the International Xenotransplantation Association, The Transplantation Society, and World Health Organization in the development of guidance documents and policies for xenotransplantati	6
The effects of necrostatin‐1 on the in vitro development and function of young porcine islets over 14‐day prolonged tissue culture	5
Xenotransplantation of neonatal porcine bone marrow–derived mesenchymal stem cells improves diabetic wound healing by promoting angiogenesis and lymphangiogenesis	5
Upfront use of eculizumab to treat early acute antibody‐mediated rejection after kidney allotransplantation and relevance for xenotransplantation	5
PCR and peptide based PCMV detection in pig – development and application of a combined testing procedure differentiating newly from latent infected pigs	5
Generation of glycans depleted decellularized porcine pericardium, using digestive enzymatic supplements and enzymatic mixtures for food industry	5
Xenotransplantation in Australia: Development of the regulatory process	5
Pig‐to‐human kidney transplantation using brain‐dead donors as recipients: One giant leap, or only one small step for transplantkind?	5

The road to the first FDA‐approved genetically engineered pig heart transplantation into human	5
Lebanese medical students’ knowledge on and attitude toward xenotransplantation and its ethical issues: A cross‐sectional study	5
Dot blots of solubilized extracellular matrix allow quantification of human antibodies bound to epitopes present in decellularized porcine pulmonary heart valves	5
Extracellular histones and xenotransplantation	5
Cytokine‐inducible promoters to drive dynamic transgene expression: The “Smart Graft” strategy	4
Human erythrocyte fragmentation during ex‐vivo pig organ perfusion	4
Immunological response in cynomolgus macaques to porcine α‐1,3 galactosyltransferase knockout viable skin xenotransplants—A pre‐clinical study	4
Development and characterization of Gal KO porcine bone marrow‐derived mesenchymal stem cells	4
Third update on possible animal sources for human COVID‐19	4
Long‐term efficacy and safety of porcine islet macrobeads in nonimmunosuppressed diabetic cynomolgus macaques	4
Generating liver using blastocyst complementation: Opportunities and challenges	4
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo‐glycans	4
Current state of clinical trials on xenograft	4
Recent progress in the pig‐to‐nonhuman primate kidney transplantation model: Report of a symposium	4
Mixed xenogeneic porcine chimerism tolerizes human anti‐pig natural antibody‐producing cells in a humanized mouse model	4
Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation	4
Opinions of nursing and theology faculty students on Xenotransplantation	4
Peritoneal dissolved oxygen and function of encapsulated adult porcine islets transplanted in streptozotocin diabetic mice	4
Detection of cell‐free pig DNA using integrated PERV sequences to monitor xenotransplant tissue damage and rejection	4
Comparison of islet isolation result and clinical applicability according to GMP‐grade collagenase enzyme blend in adult porcine islet isolation and culture	4
What will be the cost of a genetically‐engineered pig organ for clinical xenotransplantation?	4
Should you need an organ… Flemish secondary school students’ attitudes toward xenotransplantation and transgenetic organ donation	3
Patients’ opinions 10 years after receiving encapsulated porcine islet xenotransplantation without immunosuppression	3
Acceptance of xenotransplantation by patients waiting for organ donation: A qualitative study	3
Clinical trials of xenotransplantation: The need for a worldwide registry	3
US Food and Drug Administration regulatory approaches for xenotransplantation products and xenografts	3
hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood	3
Knock‐out of N‐glycolylneuraminic acid attenuates antibody‐mediated rejection in xenogenically perfused porcine lungs	3
High‐quality porcine islets isolated from aged miniature pigs	3
Scleral defect repair using decellularized porcine sclera in a rabbit model	3
Complement blockade with eculizumab to treat acute symptomatic humoral rejection after heart transplantation	3
The case for the therapeutic use of mechanistic/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation	3
Atrase B, a novel metalloprotease with anti‐complement and anti‐coagulant activity, significantly delays discordant cardiac xenograft rejection	3
First transplantation of a pig heart from a multiple gene‐modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs	3
An intrinsic link to an extrinsic cause of cardiac xenograft growth after xenotransplantation	3
Patient informed consent for a clinical trial of gene‐edited pig kidney transplantation: A representative consent form	3
3′UTR enhances hCD47 cell surface expression, self‐signal function, and reduces ER stress in porcine fibroblasts	3
Commentary on the manuscript: "Meta‐analysis of public perception towards xenotransplantation"	3
Preparing IRB members for xenotransplantation clinical trials	3
Mathieu Jaboulay's (1860–1913) contribution to xenotransplantation	3
Porcine cytomegalovirus: A very unwelcome stowaway	3
Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants	3
Abstracts	2
Recellularized bovine pericardium with autologous mesenchymal stem cells reduces immune activation	2
Introduction to the theme issue on regulatory aspects of xenotransplantation	2
Porcine‐derived medical therapies for SARS‐CoV‐2: Traversing Muslim bioethical concerns and assuring equity	2
SARS‐CoV‐2 does not infect pigs, but this has to be verified regularly	2
Incompatibility between recipient CD47 and donor SIRPα is not a key risk factor for thrombocytopenia or anemia following rat liver xenotransplantation in mice	2
The impact of IdeS (imlifidase) on allo‐specific, xeno‐reactive, and protective antibodies in a sensitized rhesus macaque model	2
In defense of xenotransplantation research: Because of, not in spite of, animal welfare concerns	2
Characterization of putative regulatory isoforms of porcine tumor necrosis factor receptor 2 in endothelial cells	2
Deceased humans and living pigs as sources of kidneys for clinical transplantation—Can they be compared?	2
On the way (my way) to clinical xenogeneic heart transplantation. Presented at the 15th biannual IXA meeting, Munich, October 11, 2019	2
By definition….	2
Xenotransplantation literature update March 2021–March 2023	2
The evidence of a macrophage barrier in the xenotransplantation of human hematopoietic stem cells to severely immunodeficient rats	2
Xenotransplantation literature update for September – October 2020	2
Xenotransplantation Literature Update January/February 2021	2
Antibodies against hyaluronan oligosaccharides in xenotransplantation	2
Immunosuppressive and metabolic agents that influence allo‐ and xenograft survival by in vivo expansion of T regulatory cells	2
A message from Mr. David Bennett Jr., the son of the first patient to receive a gene‐edited pig heart transplant	2
Natural anti‐pig antibodies in infant baboons	2
Expression profile of Tripartite motif family (TRIM) in human fibroblasts (NHDF) infected with porcine endogenous retrovirus (PERV)	2
What does the PERV copy number tell us?	2
Specificity profile of αGal antibodies in αGalT KO mice as probed with comprehensive printed glycan array: Comparison with human anti‐Galili antibodies	2
What is the clinical relevance of deviant serum calcium and phosphate levels after pig‐to‐primate kidney xenotransplantation?	2
Pancreas preservation in extracellular‐type p38 inhibitor‐containing solution improves islet yield for porcine islet isolation	2
Human anti‐α‐fucose antibodies are xenoreactive toward GGTA1/CMAH knockout pigs	2