OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Carcinogenesis is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
MiR‐15a‐3p regulates ferroptosis via targeting glutathione peroxidase GPX4 in colorectal cancer	41
Fibroblast growth factor‐2, derived from cancer‐associated fibroblasts, stimulates growth and progression of human breast cancer cells via FGFR1 signaling	38
Tocilizumab potentiates cisplatin cytotoxicity and targets cancer stem cells in triple‐negative breast cancer	36
Targeting glycosylated antigens on cancer cells using siglec‐7/9‐based CAR T‐cells	36
The interplay between cancer associated fibroblasts and immune cells in the context of radiation therapy	33
Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy	31
Circ0106714 inhibits tumorigenesis of colorectal cancer by sponging miR‐942‐5p and releasing DLG2 via Hippo‐YAP signaling	29
Breast cancer stem cells: A review of their characteristics and the agents that affect them	28
M2‐like tumor‐associated macrophages‐secreted Wnt1 and Wnt3a promotes dedifferentiation and metastasis via activating β‐catenin pathway in thyroid cancer	28
Analysis of circulating breast cancer cell heterogeneity and interactions with peripheral blood mononuclear cells	27
Nicotinamide N‐methyltransferase decreases 5‐fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect	26
Tocilizumab inhibits IL‐8 and the proangiogenic potential of triple negative breast cancer cells	26
Alternative splicing related genetic variants contribute to bladder cancer risk	25
T‐cell receptor affinity in the age of cancer immunotherapy	25
Transcriptome profiling reveals that VNPP433‐3β, the lead next‐generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial–mesenchymal transition and stem cell marker	24
Inhibiting Wnt/beta‐catenin in CTNNB1‐mutated endometrial cancer	23
Solamargine inhibits the growth of hepatocellular carcinoma and enhances the anticancer effect of sorafenib by regulating HOTTIP‐TUG1/miR‐4726‐5p/MUC1 pathway	23
IL‐6 and IL‐8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor	23
lncRNA CERS6‐AS1 as ceRNA promote cell proliferation of breast cancer by sponging miR‐125a‐5p to upregulate BAP1 expression	22
USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51‐AKT1 signaling	22
Comprehensive single institute experience with melanoma TIL: Long term clinical results, toxicity profile, and prognostic factors of response	21
Triterpenoid ursolic acid drives metabolic rewiring and epigenetic reprogramming in treatment/prevention of human prostate cancer	20
N⁶‐Methyladenosine (m⁶A) readers are dysregulated in renal cell carcinoma	19
Focal adhesion kinase (FAK) inhibitor‐defactinib suppresses the malignant progression of human esophageal squamous cell carcinoma (ESCC) cells via effective blockade of PI3K/AKT axis and downstream mo	19
The LncRNA FGD5‐AS1/miR‐497‐5p axis regulates septin 2 (SEPT2) to accelerate cancer progression and increase cisplatin‐resistance in laryngeal squamous cell carcinoma	19

ALKBH5‐mediated m6A‐demethylation of USP1 regulated T‐cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B	19
L‐fucose, a sugary regulator of antitumor immunity and immunotherapies	18
MicroRNA‐141‐3p regulates cellular proliferation, migration, and invasion in esophageal cancer by targeting tuberous sclerosis complex 1	18
The humanized mouse: Emerging translational potential	17
miR‐885‐5p inhibits proliferation and metastasis by targeting IGF2BP1 and GALNT3 in human intrahepatic cholangiocarcinoma	17
Autophagy modulates FSS‐induced epithelial–mesenchymal transition in hepatocellular carcinoma cells	16
USF1‐induced overexpression of long noncoding RNA WDFY3‐AS2 promotes lung adenocarcinoma progression via targeting miR‐491‐5p/ZNF703 axis	16
SALL4 promotes tumor progression in breast cancer by targeting EMT	16
A novel long noncoding RNA, LOC440173, promotes the progression of esophageal squamous cell carcinoma by modulating the miR‐30d‐5p/HDAC9 axis and the epithelial–mesenchymal transition	16
TP53 mutations in head and neck cancer	15
LINC02381 aggravates breast cancer through the miR‐1271‐5p/FN1 axis to activate PI3K/AKT pathway	15
Eugenol modulates genomic methylation and inactivates breast cancer‐associated fibroblasts through E2F1‐dependent downregulation of DNMT1/DNMT3A	15
Hyperactivation of MEK/ERK pathway by Ca²⁺/calmodulin‐dependent protein kinase kinase 2 promotes cellular proliferation by activating cyclin‐dependent kinases and minichromosome maintenance	15
Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo	14
FAM129B‐dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells	14
FAP^high α‐SMA^low cancer‐associated fibroblast‐derived SLPI protein encapsulated in extracellular vesicles promotes ovarian cancer development via activation of PI3K/AKT and downs	14
RNA‐seq reveals novel cancer‐selective and disease subtype‐independent mechanistic targets of withaferin A in human breast cancer cells	14
The role of transforming growth factor‐beta in immune suppression and chronic inflammation of squamous cell carcinomas	14
Anticancer activities of parthenolide in primary effusion lymphoma preclinical models	14
Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer	14
LncRNA UCA1 maintains the low‐tumorigenic and nonmetastatic status by stabilizing E‐cadherin in primary prostate cancer cells	13
Targeting mitochondrial metabolism for metastatic cancer therapy	13
A rohitukine derivative IIIM‐290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells	13
Computational modeling of malignant ascites reveals CCL5–SDC4 interaction in the immune microenvironment of ovarian cancer	13
VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal squamous cell carcinoma cancer phenotype	13
Slow N‐acetylation as a possible contributor to bladder carcinogenesis	13
CAF‐derived exosomes transmitted Gremlin‐1 promotes cancer progression and decreases the sensitivity of hepatoma cells to sorafenib	13
HPV‐16/18 E6‐induced APOBEC3B expression associates with proliferation of cervical cancer cells and hypomethylation of Cyclin D1	13
miR‐506‐loaded gelatin nanospheres target PENK and inactivate the ERK/Fos signaling pathway to suppress triple‐negative breast cancer aggressiveness	12
CMTM4 regulates epithelial–mesenchymal transition and PD‐L1 expression in head and neck squamous cell carcinoma	12
Withaferin A mediated changes of miRNA expression in breast cancer‐derived mammospheres	12
Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity	12
Myeloid derived suppressor cells in cancer, premalignancy and inflammation: A roadmap to cancer immunoprevention	11
Mcl‐1 targeting strategies unlock the proapoptotic potential of TRAIL in melanoma cells	11
USP39 mediates p21‐dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis	11
Regorafenib inhibits migration, invasion, and vasculogenic mimicry of hepatocellular carcinoma via targeting ID1‐mediated EMT	11
YAP/TEAD4‐induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma	11
Amateur antigen‐presenting cells in the tumor microenvironment	11
In vivo CRISPR–Cas9 knockout screening using quantitative PCR identifies thymosin beta‐4 X‐linked that promotes diffuse‐type gastric cancer metastasis	11
Upregulation of secreted phosphoprotein 1 affects malignant progression, prognosis, and resistance to cetuximab via the KRAS/MEK pathway in head and neck cancer	11
Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma	11
Genetic variants of the peroxisome proliferator‐activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer	11
PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway	10
Tumor‐derived exosomes: Key players in non‐small cell lung cancer metastasis and their implication for targeted therapy	10
Development and validation of 3‐CpG methylation prognostic signature based on different survival indicators for colorectal cancer	10
Associations of genetically predicted circulating insulin‐like growth factor‐1 and insulin‐like growth factor binding protein‐3 with bladder cancer risk	10
Longitudinal change of metabolite profile and its relation to multiple risk factors for the risk of developing hepatitis B‐related hepatocellular carcinoma	10
Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR)	10
H. pylori infection induces CXCL8 expression and promotes gastric cancer progress through downregulating KLF4	10
The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme	10

Mitogen‐activated protein kinase‐activated protein kinase‐2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer	9
Pharmacologic inhibition of ataxia telangiectasia and Rad3‐related (ATR) in the treatment of head and neck squamous cell carcinoma	9
Methylseleninic acid overcomes programmed death‐ligand 1‐mediated resistance of prostate cancer and lung cancer	9
TNF‐α‐dependent lung inflammation upregulates superoxide dismutase‐2 to promote tumor cell proliferation in lung adenocarcinoma	9
Twist1 is required for the development of UVB‐induced squamous cell carcinoma	9
A novel terpenoid class for prevention and treatment of KRAS‐driven cancers: Comprehensive analysis using in situ, in vitro, and in vivo model systems	9
DDIT4 promotes malignancy of head and neck squamous cell carcinoma	9
Quercetin attenuates the proliferation of arsenic‐related lung cancer cells via a caspase‐dependent DNA damage signaling	9
ARNT‐dependent CCR8 reprogrammed LDH isoform expression correlates with poor clinical outcomes of prostate cancer	9
lnc‐HOTAIR predicts hepatocellular carcinoma in chronic hepatitis C genotype 4 following direct‐acting antivirals therapy	9
SCR7, an inhibitor of NHEJ can sensitize tumor cells to ionization radiation	9
SOX6 represses tumor growth of clear cell renal cell carcinoma by HMG domain‐dependent regulation of Wnt/β‐catenin signaling	8
HSP70 promotes tumor progression by stabilizing Skp2 expression in gastric cancer cells	8
Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells	8
Immunomodulatory role of thrombin in cancer progression	8
DNA methylome, transcriptome, and prostate cancer prevention by phenethyl isothiocyanate in TRAMP mice	8
Enrichment of progenitor cells by 2‐acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo	8
Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA‐30a in breast cancer	8
Toll‐like receptor‐4 deficiency inhibits ultraviolet radiation‐induced tumor development by modulation of immune and inflammatory responses	8
SIRT2 modulates VEGFD‐associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer	8
Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis	8
Role of solute carrier transporters SLC25A17 and SLC27A6 in acquired resistance to enzalutamide in castration‐resistant prostate cancer	8
LINC00662 modulates cervical cancer cell proliferation, invasion, and apoptosis via sponging miR‐103a‐3p and upregulating PDK4	8
Comprehensive analysis of PTEN‐related ceRNA network revealing the key pathways WDFY3‐AS2 ‐ miR‐21‐5p/miR‐221‐3p/miR‐222‐3p ‐ TIMP3 as potential biomarker in tumorigenesis and prognosis of kidney rena	8
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas	8
Circ‐E‐Cad encodes a protein that promotes the proliferation and migration of gastric cancer via the TGF‐β/Smad/C‐E‐Cad/PI3K/AKT pathway	8
Alternative splicing: An important regulatory mechanism in colorectal carcinoma	8
Common tumor‐suppressive signaling of thyroid hormone receptor beta in breast and thyroid cancer cells	8
Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression	7
Effects of radiation on tumor vasculature	7
Histone demethylase JMJD1A in cancer progression and therapeutic resistance	7
Cytoprotective autophagy induction by withaferin A in prostate cancer cells involves GABARAPL1	7
Novel mechanistic targets of forkhead box Q1 transcription factor in human breast cancer cells	7
A review of Plks: Thinking outside the (polo) box	7
MYC‐binding lncRNA EPIC1 promotes AKT‐mTORC1 signaling and rapamycin resistance in breast and ovarian cancer	7
Mefloquine induces ER stress and apoptosis in BRAFi‐resistant A375‐BRAF^V600E/NRAS^Q61K malignant melanoma cells targeting intracranial tumors in a bioluminescent murine model	7
AKR1C3 suppresses ferroptosis in hepatocellular carcinoma through regulation of YAP/SLC7A11 signaling pathway	7
HIF‐1α‐regulated stanniocalcin‐1 mediates gemcitabine resistance in pancreatic ductal adenocarcinoma via PI3K/AKT signaling pathway	7
MicroRNA‐519d‐3p antagonizes osteosarcoma resistance against cisplatin by targeting PD‐L1	7
Identification of a novel TNRC18‐RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML‐RARA	7
Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer	7
Cucurbitacin I (JSI‐124)‐dependent inhibition of STAT3 permanently suppresses the pro‐carcinogenic effects of active breast cancer‐associated fibroblasts	7
Diagnostic potential of circulating cell‐free nuclear and mitochondrial DNA for several cancer types and nonmalignant diseases: A study on suspected cancer patients	7
Systematic evaluation of the predictive gene expression signatures of immune checkpoint inhibitors in metastatic melanoma	7
Pharmacologic approaches to amino acid depletion for cancer therapy	7
Periostin secreted from podoplanin‐positive cancer‐associated fibroblasts promotes metastasis of gastric cancer by regulating cancer stem cells via AKT and YAP signaling pathway	6
Association of RANK and RANKL gene polymorphism with survival and calcium levels in multiple myeloma	6
Combined inhibition of BET bromodomain and mTORC1/2 provides therapeutic advantage for rhabdomyosarcoma by switching cell death mechanism	6
PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia	6
Transcriptional repression of E‐cadherin in nickel‐exposed lung epithelial cells mediated by loss of Sp1 binding at the promoter	6
Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma	6
The pancreatic cancer immune tumor microenvironment is negatively remodeled by gemcitabine while TGF‐β receptor plus dual checkpoint inhibition maintains antitumor immune cells	6
Risk SNP‐mediated LINC01614 upregulation drives head and neck squamous cell carcinoma progression via PI3K/AKT signaling pathway	6
Low expression of lncRNA SBF2‐AS1 regulates the miR‐302b‐3p/TGFBR2 axis, promoting metastasis in laryngeal cancer	6
Animal model and bioinformatics analyses suggest the TIMP1/MMP9 axis as a potential biomarker in oral squamous cell carcinoma	6
Intratumoural heterogeneity and clone evolution of oral squamous cell carcinoma	6
The potential underlying mechanism of the leukemia caused by MLL‐fusion and potential treatments	6
Ebp1 p48 promotes oncogenic properties in hepatocellular carcinoma through p38 MAPK/HIF1α activation and p53 downregulation	5
Bitter melon juice intake with gemcitabine intervention circumvents resistance to gemcitabine in pancreatic patient‐derived xenograft tumors	5
Silencing of UAP1L1 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma	5
Loss of prdm1a accelerates melanoma onset and progression	5
Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR‐1343‐3p/Bcl‐3 axis through TGFβ/Smad3/EMT signaling	5
Review: PD‐L1 as an emerging target in the treatment and prevention of keratinocytic skin cancer	5
Sulforaphane inhibits PRMT5 and MEP50 function to suppress the mesothelioma cancer cell phenotype	5
RAS induced senescence of skin keratinocytes is mediated through Rho‐associated protein kinase (ROCK)	5
Harnessing the power of the immune system in cancer immunotherapy and cancer prevention	5
Cancer biology functional genomics: From small RNAs to big dreams	5
HET0016 attenuates the stemness of breast cancer cells through targeting CYP4Z1	5
Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells	5
Regulation of programmed death ligand 1 (PD‐L1) expression by TNF‐related apoptosis‐inducing ligand (TRAIL) in triple‐negative breast cancer cells	5
Role of hemoglobin alpha and hemoglobin beta in non‐small‐cell lung cancer based on bioinformatics analysis	5
p21‐activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1	5
NUAK family kinase 2 is a novel therapeutic target for prostate cancer	5
Long noncoding RNA TFAP2A‐AS1 promotes oral squamous cell carcinoma cell growth and movement via competitively binding miR‐1297 and regulating TFAP2A expression	5
Monocarboxylate transporter 1 is a novel target for breast cancer stem like‐cell inhibition by diallyl trisulfide	5
PUS7 promotes the proliferation of colorectal cancer cells by directly stabilizing SIRT1 to activate the Wnt/β‐catenin pathway	5
The interaction between PDCD4 and YB1 is critical for cervical cancer stemness and cisplatin resistance	5
Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline‐deficient l‐amino acid‐defined diet prevents hepatocarcinogenesis in mice	5