OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Carcinogenesis is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
	46
Issue Information ‐ Ed Board	45
Cover Image, Volume 62, Issue 4	43
The Parkinson's disease‐associated protein α‐synuclein inhibits hepatoma by exosome delivery	35
Combined Inhibition of XPO1 and DNA Methylation Exerts Synergistic Effects in DLBCL	33
Inhibition of the RBMS1/PRNP axis improves ferroptosis resistance‐mediated oxaliplatin chemoresistance in colorectal cancer	31
Potentiated effects of lactate receptor GPR81 on immune microenvironment in breast cancer	29
Delta‐Like Homolog 2 Facilitates Malignancy of Hepatocellular Carcinoma via Activating EGFR/PKM2 Signaling Pathway	27
Forkhead Box Q1 is a novel regulator of autophagy in breast cancer cells	26
PTPN2 Expression in Hypopharyngeal Squamous Cell Carcinoma and Its Clinical Significance	26
UBE2D1 promotes glioblastoma proliferation by modulating p21 ubiquitination	24
CRISPR‐Based Gene Dependency Screens Reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer	24
RELA promotes the progression of oral squamous cell carcinoma via TFAP2A‐Wnt/β‐catenin signaling	23
HNRNPC promotes estrogen receptor‐positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A‐dependent manner	23
Predictive Value of Neutrophil Extracellular Traps in Neoadjuvant Chemotherapy for Muscle‐Invasive Bladder Cancer	23
SIRT1 promotes doxorubicin‐induced breast cancer drug resistance and tumor angiogenesis via regulating GSH‐mediated redox homeostasis	23
Histone lactylation facilitates hepatocellular carcinoma progression by upregulating endothelial cell‐specific molecule 1 expression	22
IRF2BP2 drives lymphatic metastasis in OSCC cells by elevating mitochondrial fission‐dependent fatty acid oxidation	21
The FOXO1/G6PC axis promotes gastric cancer progression and mediates 5‐fluorouracil resistance by targeting the PI3K/AKT/mTOR signaling pathway	20
Issue Information ‐ Ed Board	19
	19
	19
Issue Information ‐ Ed Board	19
Venetoclax Synergizes With Regorafenib for Colorectal Cancer by Targeting BCL‐2	18
	18

Blocking the ATR‐SerRS‐VEGFA pathway targets angiogenesis for UV‐induced cutaneous squamous cell carcinoma	17
Oncogenic fusion of CD63‐BCAR4 contributes cancer stem cell‐like properties via ALDH1 activity	17
VPS45 Contributes to the Progression of Hepatocellular Carcinoma by Triggering the Wnt/β‐Catenin Signaling Pathway	17
Hepatitis B Virus X Protein Contributes to Hepatocellular Carcinoma via Upregulation of KIAA1429 Methyltransferase and mRNA m6A Hypermethylation of HSPG2/Perlecan	17
	17
Identification of concurrent STAT3::RARA and RARA::STAT5b fusions in a variant APL case	17
Transmembrane protein 147, as a potential Sorafenib target, could expedite cell cycle process and confer adverse prognosis in hepatocellular carcinoma	16
Circ_0007429/miR‐637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC	16
Atypical BCR‐ABL1 transcript in mixed phenotype acute leukemia with bone marrow necrosis	16
Homologous recombination repair gene mutations in colorectal cancer favors treatment of immune checkpoint inhibitors	16
DNTT activation, TdT‐aided gene length mutation, and better prognosis in ATG‐based regimen allo‐HSCT in AML	16
Identification of a Novel RUNX1::HMGN1 Fusion in Therapy Acute Myeloid Leukemia	16
High‐Fat Diet Promotes Glycolysis in Hepatocellular Carcinoma by Suppressing Hepatic Kisspeptin Signaling in Mice	16
HORMAD1 Polymorphisms Influence Susceptibility to Esophageal Squamous Cell Carcinoma Through Gene–Smoking Interaction	16
Correction to “Cucurbitacin B Induces Inhibitory Effects via CIP2A/PP2A/Akt Pathway in Glioblastoma Multiforme”	16
ELOVL6 promotes the progression of head and neck squamous cell carcinoma via activating WNT/β‐catenin pathway	16
AKR1C3 suppresses ferroptosis in hepatocellular carcinoma through regulation of YAP/SLC7A11 signaling pathway	15
Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells	15
Divergence of mutational signatures in association with breast cancer subtype	15
β‐Elemene Inhibits Adrenocortical Carcinoma Cell Proliferation and Migration, and Induces Apoptosis by Up‐Regulating miR‐486‐3p/Targeting NPTX1 Axis	15
ZNF695 Promotes Colorectal Cancer Progression Through Transcriptional Activation of CBX8 and Subsequent Wnt/β‐Catenin Signaling Activation	15
	15
Issue Information ‐ Ed Board	15
YTHDF1 enhances stemness and chemoresistance in triple‐negative breast cancer cells by upregulating SIAH2	15
	15
Levels of Bile Acid Metabolism Are Associated With Alterations of Gut Microbes in Hepatocellular Carcinoma	15
CYP4F11, an NRF2 Target Gene, Promotes Hepatocellular Carcinoma Cell Growth	14
KNTC1 knockdown inhibits the proliferation and migration of osteosarcoma cells by MCM2	14
	14
Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5	14
Plakophilin 1 in carcinogenesis	14
Inhibition of Growth and Survival of Head and Neck Cancer Cells by Silibinin Involves the Down‐Regulation of Erk1/2, AKT and STAT3 Signaling	14
Targeting TROP2 and Exploiting AUNIP as a Determinant of ADC Cytotoxicity and Chemosensitivity in HNSCC and ESCA Cancers	14
Issue Information ‐ Ed Board	13
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway	13
Upregulation of collagen type X alpha 1 promotes the progress of triple‐negative breast cancer via Wnt/β‐catenin signaling	13
HMGB3 Contributes to Anti‐PD‐1 Resistance by Inhibiting IFN‐γ‐Driven Ferroptosis in TNBC	13
A‐to‐I‐Edited miR‐1304‐3p Inhibits Glycolysis and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inactivating Wnt5a/ROR2 Signaling	13
The 5‐Methylcytosine RNA Modification in Hepatitis B Virus‐Negative Hepatocellular Carcinoma: Insights From Long‐Read Nanopore Sequencing	13
HDAC inhibitor regulates the tumor immune microenvironment via pyroptosis in triple negative breast cancer	13
SFRP2 ⁺ CAFs Expressing Myofibroblastic Phenotype Are Involved in Glutamine Metabolism and Malignant Behaviors of Laryngeal Squamous Cell Carcinoma b	13
Doublecortin‐like kinase 1 is a therapeutic target in squamous cell carcinoma	13
Tissue‐of‐origin for cancers determines HIF‐1 activation induced phenotypic heterogeneity	13
Imatinib Impedes EMT and Notch Signalling by Inhibiting p300 Acetyltransferase in Breast Cancer Cells	13
Potential Crosstalk Between ANXA1+ Epithelial Cells and FABP4+ TAM Cells of Ferroptosis‐Related Molecular Clusters Promotes an Immunosuppressive Microenvironment in Non‐Small Cell Lung Cancer	13
Sodium Overload–Related Molecular Subtypes and a Four‐Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia	12
	12
Evaluation of Epidermal Growth Factor Receptor and Its Inducible Feedback Inhibitor Leucine Rich Repeats and Immunoglobulin Like Domains 1 as Prognostic Marker in Oral Cancer	12
Loss of PTPRS elicits potent metastatic capability and resistance to temozolomide in glioblastoma	12
Energy balance‐related factors in childhood and adolescence and risk of colorectal cancer based on KRAS, PIK3CA, and BRAF mutations and MMR status	12

M2 macrophage exosome‐derived Apoc1 promotes ferroptosis resistance in osteosarcoma by inhibiting ACSF2 deubiquitination	12
	12
Association of SIRT6 Expression With Risk of Pneumonitis Induced by Radiotherapy in Cancer Patients	12
EXPRESSION OF CONCERN: Growth Inhibition of Pancreatic Cancer Cells by Histone Deacetylase Inhibitor Belinostat Through Suppression of Multiple Pathways Including Hif, Nfkb,	12
Linarin Suppresses the Progression of Colorectal Cancer by Inhibiting the HIF‐1α/PD‐L1 Axis	12
LATS‐regulated nuclear‐cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial–mesenchymal transition	12
Predictive significance of PRR11 in prognosis and immune infiltration of glioma patients	12
Cover Image, Volume 62, Issue 2	12
Review: PD‐L1 as an emerging target in the treatment and prevention of keratinocytic skin cancer	12
HER3 V104 mutations regulate cell signaling, growth, and drug sensitivity in cancer	12
Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane	11
A variant in CYP26B1 associated with esophageal squamous cell carcinoma risk by affecting retinoic acid metabolism	11
A Combinatorial Model of Serum tsRNAs as a Diagnostic Biomarker for Non‐Small Cell Lung Cancer	11
Deciphering CD4⁺ T cell‐mediated responses against cancer	11
A systems biology‐based approach to screen key splicing factors in hepatocellular carcinoma	11
Regulation of programmed death ligand 1 (PD‐L1) expression by TNF‐related apoptosis‐inducing ligand (TRAIL) in triple‐negative breast cancer cells	11
Genetic variations associated with telomere length predict the risk of recurrence of non‐oropharyngeal head and neck squamous cell carcinoma	11
The HDAC2–MTA3 interaction induces nonsmall cell lung cancer cell migration and invasion by targeting c‐Myc and cyclin D1	11
Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF‐κB pathway, and elevated MMP13 expression	11
	11
Diosmetin: A dietary flavone as modulator of signaling pathways in cancer progression	11
The cumulative antitumor effects of regorafenib and radiotherapy in hepatocellular carcinoma	11
Integrative Bioinformatics Analysis and Experimental Study of NLRP12 Reveal Its Prognostic Value and Potential Functions in Ovarian Cancer	11
The JAK3^Q988P mutation reveals oncogenic potential and resistance to ruxolitinib	11
Targeting Hippo/YAP in intrahepatic cholangiocarcinoma: Promising molecules in cancer therapy	11
Computed Tomography‐Based Radiomics and Genomics Analyses for Survival Prediction of Stage III Unresectable Non‐Small Cell Lung Cancer Treated With Definitive Chemoradiotherapy and Immunotherapy	11
Breast Cancer‐Derived AZU1 Educates Neutrophils to Promote Tumor Progression and Metastasis Through PAD4‐Dependent Extracellular Trap Formation	11
Epitranscriptomic Regulation of ALDOA by SHMT2‐Mediated m6A Modification Drives Gastric Cancer Malignancy	10
Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling	10
Monocarboxylate Transporter‐1 Is Dispensable for Hepatocellular Carcinoma Development	10
KCNE3 Facilitates M1 Macrophage Polarization by Suppressing the Wnt/β‐Catenin Pathway, Inhibiting Glioma Proliferation, Migration, and Invasion	10
circEIF3I Promotes Colorectal Cancer Metastasis by Regulating the miR‐328‐3p/NCAPH Axis	10
Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression	10
HIF‐1α regulates the cell viability in radioiodine‐resistant papillary thyroid carcinoma cells induced by hypoxia through PKM2/NF‐κB signaling pathway	10
	10
GRPEL2 Modulates Apoptosis in Esophageal Squamous Cell Carcinoma via the JNK Signaling Pathway	10
	10
MicroRNA‐505‐5p/‐3p Regulates the Proliferation, Invasion, Apoptosis, and Temozolomide Resistance in Mesenchymal Glioma Stem Cells by Targeting AUF1	10
Baicalein promotes KDM4E to induce BICD1 and inhibit triple‐negative breast cancer progression by blocking PAR1 signaling	10
GRP78 promotes bone metastasis of prostate cancer by regulating bone microenvironment through Sonic hedgehog signaling	10
	10
Lesser prevalence of polyps/WNT‐dysregulation and concomitant upregulation of gamma‐catenin/MYC point to alternate pathways in colorectal cancer in India	10
TRIM16 E121D variant affects the risk and prognosis of hepatocellular carcinoma by modulating the Wnt/β‐catenin pathway	10
Integrated Analysis Reveals ZNF184 as a Novel Regulator of Stemness‐Associated Paclitaxel Resistance and Tumor Progression in Breast Cancer	10
BORIS variant SF2(C2/A4) promotes the malignant development of liver cancer by activating epithelial‐mesenchymal transition and hepatic stellate cells	10
circPPP2R4 promotes colorectal cancer progression and reduces ROS production through the miR‐646/FOXK1 axis	9
Corrigendum	9
Sulforaphane impaired immune checkpoint blockade therapy through activating ΔNP63α/PD‐L1 axis in gastric cancer	9
CD137 Protein Expression Pattern Determines the Functional Role of Galectin‐9 in Colorectal Cancer	9
NSUN2 promotes lung adenocarcinoma progression through stabilizing PIK3R2 mRNA in an m⁵C‐dependent manner	9
Harnessing Cuproptosis for Antitumor Immunity: A Review of Current Evidence and Therapeutic Strategies	9
CDK10 suppresses metastasis of lung adenocarcinoma through inhibition of the ETS2/c‐Raf/p‐MEK/p‐ERK signaling loop	9
NSUN2 Promotes Prostate Cancer Cell Proliferation and Migration Through m5C Modifications of YES1	9
KDM6A Exhibits Antitumor Activities Toward Ovarian Cancer by Epigenetically Activating Transcription of ISG‐15	9
Associations of mitochondrial DNA copy number with incident risks of gastrointestinal cancers: A prospective case–cohort study	9
HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway	9
Dysregulated BCL9 Controls Tumorigenicity and Ferroptosis Susceptibility by Binding With Nrf2 in Thyroid Carcinoma	9
SRPK1 Activation Facilitates Gli3^S664 Phosphorylation and Promotes Metastasis in Esophageal Squamous Cell Carcinoma	9
AN02, a Naovel Curcumin Derivative, Orchestrates APC‐SMAD4‐Mediated CTLA‐4 Degradation for Ovarian Cancer Therapy	9
Metabolism‐focused CRISPR screen unveils mitochondrial pyruvate carrier 1 as a critical driver for PARP inhibitor resistance in lung cancer	9
KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradation	9
Triiodothyronine (T3) suppresses hepatic tumorigenesis and development by inhibiting the phosphorylation of ERK	9
Whole‐Genome Bisulfite Sequencing Identifies Blood‐Based DNA Methylation Biomarker for Hepatocellular Carcinoma	9
Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis	8
microRNA‐2117 Negatively Regulates Liver Cancer Stem Cells Expansion and Chemoresistance Via Targeting SOX2	8
γ‐Tocotrienol enhances autophagy of gastric cancer cells by the regulation of GSK3β/β‐Catenin pathway	8
ZNF480 Accelerates Chemotherapy Resistance in Breast Cancer by Competing With TRIM28 and Stabilizing LSD1 to Upregulate the AKT‐GSK3β‐Snail Pathway	8
ACKR3 orchestrates Hedgehog signaling to promote renal cell carcinoma progression	8
Acylglycerol Kinase Sensitizes Glioblastoma to Temozolomide via Limiting Mitochondrial Damage Related Cellular Senescence	8
Mass cytometry and transcriptomic profiling reveal PD1 blockade induced alterations in oral carcinogenesis	8
Loss of SETD2‐mediated downregulation of intracellular and exosomal miRNA‐10b determines MAPK pathway activation and multidrug resistance in renal cancer	8
Alkaliptosis induction counteracts paclitaxel‐resistant ovarian cancer cells via ATP6V0D1‐mediated ABCB1 inhibition	8
TMED3 stabilizes SMAD2 by counteracting NEDD4‐mediated ubiquitination to promote ovarian cancer	8
ATP citrate lyase promotes the progression of hepatocellular carcinoma by activating the REGγ‐proteasome pathway	8
Regulation of SELENOF translation by eIF4a3: Possible role in prostate cancer progression	8
Liquiritin Enhances Chemosensitivity to Doxorubicin in Breast Cancer by Promoting Ubiquitination‐Mediated Degradation of MCL1	8
	8
Tumor‐derived extracellular vesicles confer 5‐fluorouracil resistance in esophageal cancer via long noncoding RNA AC116025.2 delivery	8
Issue Information ‐ Ed Board	8
Cover Image, Volume 63, Issue 5	8

LUCAT1 Mediates MYC‐Targeted Suppression of Squamous Cell Carcinoma	8
Characterizing Genetic Susceptibility to Colorectal Cancer in Taiwan Through Genome‐Wide Association Study	8
	8
RUNX1 Directly Activates WNT2 to Orchestrate Tumor‐Associated Macrophage Reprogramming in Colorectal Cancer	8
Issue Information ‐ Ed Board	8
Dihydroartemisinin synergistically enhances the cytotoxic effects of oxaliplatin in colon cancer by targeting the PHB2‐RCHY1 mediated signaling pathway	8
	8
Precision therapy for cancer prevention by targeting carcinogenesis	7
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells	7
KIN17 promotes cell migration and invasion through stimulating the TGF‐β/Smad2 pathway in hepatocellular carcinoma	7
JD‐02, a novel Hsp90 inhibitor, induces ROS/SRC axis‐dependent cytoprotective autophagy in colorectal cancer cells	7
FAP positive cancer‐associated fibroblasts promote tumor progression and radioresistance in esophageal squamous cell carcinoma by transferring exosomal lncRNA AFAP1‐AS1	7
Adipocytes Promote Endometrial Cancer Progression Through Activation of the SIRT1‐HMMR Signaling Axis	7
Molecular Analysis of Genes CEBPA, NPM1, IDH1, and RUNX1 Polymorphisms as Biomarker Potential in Leukemia Patients	7
PKMYT1 induced by YAP/TEAD1 gives rise to the progression and worse prognosis of bladder cancer	7
Drug‐target Mendelian randomization revealed a significant association of genetically proxied metformin effects with increased prostate cancer risk	7
Expression of Concern: Amplification of Cyclinl1 in Uterine Cervical Carcinoma Has Prognostic Implications	7
Hypoxia Promotes Malignant Progression of Colorectal Cancer by Inducing POSTN⁺ Cancer‐Associated Fibroblast Formation	7
BATF promotes extramedullary infiltration through TGF‐β1/Smad/MMPs axis in acute myeloid leukemia	7
Effect of CHRDL1 on angiogenesis and metastasis of colorectal cancer cells via TGF‐β/VEGF pathway	7
Glutamine, Serine and Glycine at Increasing Concentrations Regulate Cisplatin Sensitivity in Gastric Cancer by Posttranslational Modifications of KDM4A	7
CircDUSP1 regulates tumor growth, metastasis, and paclitaxel sensitivity in triple‐negative breast cancer by targeting miR‐761/DACT2 signaling axis	7
ZMYM4 Acts as a Potential Prognostic Biomarker and Promotes the Malignant Progression of Hepatocellular Carcinoma Cells: It Is Regulated by miR‐34a‐5p	7
G2 and S phase‐expressed‐1 induces chromosomal instability in esophageal squamous cell carcinoma cells and inhibits cell apoptosis through ROS/JNK signaling	7
Issue Information ‐ Ed Board	7
Spatial Transcriptomic Landscape of Canine Oral Squamous Cell Carcinoma	7
Pregnane X Receptor Activation Induces Ferroptosis Resistance Through Upregulation of FSP1	7
	7
Issue Information ‐ Ed Board	7
RETRACTION: Arsenic Exposure Through Drinking Water Leads to Senescence and Alteration of Telomere Length in Humans: A Case‐Control Study in West Bengal, India	7
KLHDC7B as a novel diagnostic biomarker in urine exosomal mRNA promotes bladder urothelial carcinoma cell proliferation and migration, inhibits apoptosis	7
Elucidating the Mechanism of 1,4,5,6,7,8‐Hexahydropyrido[4,3‐d]Pyrimidine‐Induced Inhibition of Glioma Growth Through miR‐873‐3p	7
Uncovering the Role of DNA Repair Impairment in UVA‐Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells	7
Corrigendum	7
A systems biology approach and in vitro experiment indicated Rapamycin targets key cancer and cell cycle‐related genes and miRNAs in triple‐negative breast cancer cells	7
Radiotherapy and Immune System Interactions Historical Perspectives and Clinical Advancements	7
The serine protease CORIN promotes progression of gastric cancer by mediating the ERK1/2 MAPK pathway	7
	7
Effects of Isorhapontigenin on Cell Viability, Colony‐Forming Efficiency, and Ferroptosis via Methyltransferase‐Like 14‐Mediated m ⁶ A Modification o	7
Daurisoline suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting MEK1/2 kinase	7
TRAF6 Exerts Tumor‐Promoting Effects via Genetic and Autophagic Modulation in Gastric Cancer	7
CNOT4 suppresses nonsmall cell lung cancer progression by promoting the degradation of PAF1	7
The efficacy and safety of pH‐responsive and photothermal‐sensitive multifunctional nanoparticles loaded with cryptotanshinone for the treatment of gastric cancer	7
Identification of Plasma rRNA‐Derived Small RNA Biomarkers for Diagnosis of Colorectal Cancer	7
Issue Information ‐ Ed Board	7
PDZ‐binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway	7