Journal of Clinical Epidemiology

Article	Citations
Visualizing the value of diagnostic tests and prediction models, part III. Numerical example with discrete risk groups and miscalibration	333
Meta-analysis of individual participant data and informed consent: a small step, but important and neglected	261
Guideline organizations’ guidance documents paper 10: developing recommendations about diagnostic tests and strategies	217
Empirical evaluation of the methods used in systematic reviews including observational studies and randomized trials	213
Strong and high-quality evidence synthesis needs Cochrane: a statement of support by the GRADE Guidance Group	160
The construct of certainty of evidence has not been disseminated to systematic reviews and clinical practice guidelines; response to ‘The GRADE Working Group’ et al	141
Editorial Board	141
A general explanation of the counterfactual definition of confounding	139
Use of artificial intelligence to support the assessment of the methodological quality of systematic reviews	134
Harms were detected but not reported in six clinical trials of gabapentin	129
Corrigendum to ‘Identifying type 1 and 2 diabetes in research datasets where classification biomarkers are unavailable: assessing the accuracy of published approaches’ [Journal of Clinical Epidemiolog	125
Screening colonoscopy similarly prevented distal and proximal colorectal cancer: a prospective study among 55–69-year-olds	123
A Bayesian-adaptive decision-theoretic approach can reduce the sample sizes for multiarm exercise oncology trials	123
RETRACTED: Part II: a step-by-step guide to latent class analysis	105
External validation of six COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting	102
Types and associated methodologies of overviews of reviews in health care: a methodological study with published examples	102
Two-decade health-related quality of life and performance on physical function tests in midaged women: findings from a prospective cohort study	100
Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence	97
Potential interactions between digoxin and direct oral anticoagulants: application of cohort & novel case-crossover designs	94
Predicting COVID-19 prognosis in the ICU remained challenging: external validation in a multinational regional cohort	85
Librarian involvement in systematic reviews was associated with higher quality of reported search methods: a cross-sectional survey	84
Pharmacovigilance studies without a priori hypothesis: systematic review highlights inappropriate multiple testing correction procedures	84
Methodological use and report of AMSTAR 2: a cross-sectional study	76
Integrating personomics into precision medicine	72
Rethinking Methodological Appraisal in Overviews of Systematic Reviews: A Participatory Validation Framework	69

Reporting of funding and conflicts of interest improved from preprints to peer-reviewed publications of biomedical research	69
Statistical robustness of randomized controlled trials in high-impact journals has improved but was low across medical specialties	66
External validation, impact assessment and clinical utilization of clinical prediction models: a prospective cohort study	64
Modified case-crossover estimators were unbiased in the presence of temporal trends in the exposure of interest: a simulation study	63
Advances in methodologies of negative controls: a scoping review	63
The walking man approach to interpreting the receiver operating characteristic curve and area under the receiver operating characteristic curve	63
Whole population cohorts vs sampled comparators designs for evaluating health and educational outcomes of children with inborn rare conditions: a simulation study	61
Measuring the environmental impact of health interventions in randomized controlled trials – A scoping review	59
GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses	59
Searching two or more databases decreased the risk of missing relevant studies: a metaresearch study	56
JBI series paper 2: tailored evidence synthesis approaches are required to answer diverse questions: a pragmatic evidence synthesis toolkit from JBI	55
Evaluation of tools used to assess adherence to PRISMA 2020 reveals inconsistent methods and poor tool implementability: part I of a systematic review	54
Results reporting for clinical trials led by medical universities and university hospitals in the nordic countries was often missing or delayed	53
Handling missing data in clinical research	51
Editors' Choice September 2024	49
Table of Contents	49
Editors’ Choice: October 2024	48
The World Conference on Research Integrity 2024	47
Is it time for a common peer review format for biomedical journals?	46
Heterogeneity across outcomes reported in clinical trials for older adults with depression: a systematic survey	46
Year-to-year variation in attack rates could result in underpowered respiratory syncytial virus vaccine efficacy trials	46
A population-based recalibration method for updating survival neural networks models for cardiovascular risk prediction in United Kingdom and China	45
The performance of three nutritional tools varied in colorectal cancer patients: a retrospective analysis	45
Improved reporting of selection processes in clinical database research: author's reply	44
Table of Contents	44
Table of Contents	43
Prevalence of and factors associated with potentially redundant randomized controlled trials: a cross-sectional study	43
Response to “Homeopathy: A null field or effective psychotherapy?”	42
Many systematic reviews with a single author are indexed in PubMed	40
Meta-analysis of multi-jurisdictional health administrative data from distributed networks approximated individual-level multivariable regression	40
A method was developed for correcting the bias in the usual study weights in meta-analyses	40
Incorporating postmenopausal women's perspectives into osteoporosis clinical guidelines: a systematic review	39
Indirectness (transferability) is critical when considering existing economic evaluations for GRADE clinical practice guidelines: a systematic review	38
A multimethods randomized trial found that plain language versions improved parents’ understanding of health recommendations	38
Resourcing and validation of the GRADE ontology: reply to Dedeepya et al.	37
Priority-setting criteria for clinical practice guideline development on rare genetic neurodevelopmental disorders: a Delphi study within the European Reference Network ITHACA	37
Editorial Board	37
Promoting responsible scientific research: integrating retractions into the ORCID profile	37
Improving grading of recommendations assessment, development, and evaluation evidence tables part 4: a three-arm noninferiority randomized trial demonstrates improved understanding of content in summa	36
Controversy and debate: challenges with the need to improve the reference standard in diagnosis paper 1: two challenges: absence of a clear cut, easily replicable test for the reference standard; unet	36
Item response theory may account for unequal item weighting and individual-level measurement error in trials that use PROMs: a psychometric sensitivity analysis of the TOPKAT trial	36
Predictors of citation rates and the problem of citation bias: a scoping review	35
Consistency of protocol and safety data reporting in clinical trial registrations and corresponding publications of interventions involving MDMA and psilocybin	35
Maternal early warning scores shown to be methodologically weak and at high risk of bias	34
Conflict of interest policies for editors and peer reviewers in medical journals: cross-sectional study	34
Avoiding overadjustment bias in social epidemiology through appropriate covariate selection: a primer	34
Methodological quality assessment tools for diagnosis and prognosis research: overview and guidance	34
Methods used by guideline developers to create out-of-hospital health guidelines: a cross-sectional survey	32
Editorial Board	31
Editors' Choice - July 2023	31

A framework for evaluating predictive models	31
The impact of climate change on health needs structured evidence assessment and an evidence to action framework to make decisions: a proposal to adopt the GRADE approach	30
Re: living recommendations do not ‘flip-flop’ - Examining the probability of directional changes to recommendations in living guidelines	30
A metaresearch study finds unclear impact of institutional conflicts of interest on conclusions of studies investigating volume–outcome relationships	30
Editors’ Choice January 2025	30
Reply: A needed evolution in GRADE to address dissemination (publication) bias	29
Use of participant data and biological samples is insufficiently described in participant information leaflets	29
Including nonrandomized studies of interventions in systematic reviews: principles and practicalities	29
Characteristics and completeness of reporting of systematic reviews of prevalence studies in adult populations: a metaresearch study	29
Systematic review of multivariable prognostic models for outcomes at least 30 days after hip fracture finds 18 mortality models but no nonmortality models warranting validation	28
Assessing the scientific integrity of the collected work of one author or author group	28
Accounting for differential exclusions in the Nordic-European initiative on colorectal cancer trial discloses stronger-than-reported effects of screening colonoscopy	28
Implementing a randomization consent to enable Trials within Cohorts in the Swiss HIV Cohort Study – A mixed-methods study	28
Validation of the Persistent Somatic Symptom Stigma Scale for Healthcare Professionals	28
Including conference abstracts rarely changed systematic review conclusions: a case study from a living network meta-analysis of COVID-19 treatments	27
Regulatory context for protocol amendments and public reporting in psychedelic trials	27
A methodological review of network meta-analyses applied to complex interventions for public health and a typology of the node-making process	27
Editors’ Choice: June 2026	27
A new taxonomy is proposed for defining the interests of stakeholders’ representatives in health research: the case of guideline development	27
Health state utility differed systematically in breast cancer patients between the EORTC QLU-C10D and the PROMIS Preference Score	27
How should covariates be handled in randomized trials? Empirical evidence from 50 trials and recommendations for practice	26
Part I: A friendly introduction to latent class analysis	26
Defining decision thresholds for judgments on health benefits and harms using the grading of recommendations assessment, development, and evaluation (GRADE) evidence to decision (EtD) frameworks: a ra	26
Methods for living guidelines: early guidance based on practical experience. Paper 5: decisions on methods for evidence synthesis and recommendation development for living guidelines	26
Incorporating non-randomized evidence in cochrane intervention reviews: a scoping review	25
Table of Contents	25
In a pilot study, automated real-time systematic review updates were feasible, accurate, and work-saving	25
GRADE guidance 36: updates to GRADE's approach to addressing inconsistency	25
Qualitative study of guideline panelists: innovative surveys provided valuable insights regarding patient values and preferences	25
Use of clustering techniques for clinical and epidemiological research: practical tips using an example from rheumatology	24
AMSTAR 2 is only partially applicable to systematic reviews of non-intervention studies: a meta-research study	24
New research questions identified for Cochrane reviews: a cross-sectional study of a specialized register: part two: fertility	24
Guideline organizations’ guidance documents paper 4: interest-holder engagement	24
Author’s reply: “The importance of properly specifying your target trial emulation: commentary on Mésidor et al.”	24
13-Year colorectal cancer risk after lower-quality, higher-quality and no screening colonoscopy: a cohort study	24
Surrogate endpoint metaregression: useful statistics for regulators and trialists	24
Answers to comments by Jonas Schmidt, Casper Urth Pedersen, and Sisse Helle Njor	24
Reporting of health equity considerations in vaccine trials for COVID-19: a methodological review	24
Statistical strategies to analyze local control after radiotherapy	23
Implementation of a dynamic model updating pipeline provides a systematic process for maintaining performance of prediction models	23
Prevalence of patient partner authorship and acknowledgment in child health research publications: an umbrella review	23
Editorial, April 2025	23
Underserved groups remain underserved as eligibility criteria routinely exclude them from breast cancer trials	23
Pain and physical function are common core domains across 40 core outcome sets of musculoskeletal conditions: a systematic review	23
Gynecological trials frequently exclude people based on their symptoms rather than their condition: a systematic review of Cochrane reviews and their component trials	23
Joint modeling of endpoints can be used to answer various research questions in randomized clinical trials	23
Peer review reports of randomized controlled trials in oncology can be short and superficial	23
Broadening the scope of meta-research: from methodologists to interest-holders	22
Toward an observatory of the evolution of clinical trials through phylomemy reconstruction: the COVID-19 vaccines example	22
Table of Contents	22
Developing and externally validating multinomial prediction models for methotrexate treatment outcomes in patients with rheumatoid arthritis: results from an international collaboration	22
No short-term mortality from benzodiazepine use post-acute ischemic stroke after accounting for bias	22
Mapping intersectional sociodemographic inequalities in measurement and prevalence of depressive symptoms: a intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy	22
The use of guidelines in multimorbidity-related practice: an exploratory questionnaire survey	21
Adapting World Health Organization COVID-19 living guidelines balancing methodological rigor with efficiency and flexibility: a case study from Argentina	21
Validation and impact of algorithms for identifying variables in observational studies of routinely collected data	21
Reply to “Some additional considerations on the evidence for fluoxetine in pediatric depression”	20
Gastrointestinal prophylaxis for COVID-19: an illustration of severe bias arising from inappropriate comparators in observational studies	20
A scoping review of the assessment reports of genetic or genomic tests reveals inconsistent consideration of key dimensions of clinical utility	20
The role of scoping reviews in guideline development	19
AI-enabled exploitation of open science: a response to Zil-E-Ali on safeguarding data research integrity	19
Generative artificial intelligence and academic writing: friend or foe?	19
Flexible approaches to clinical trials	19
Patient-reported outcomes and measures are under-utilised in advanced therapy medicinal products trials for orphan conditions	19
Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis	19
Psychometric properties and reference values for the instrumented timed-up and go test in adults	19
Ratios are misleading exposure variables that compromise a regression model unless fundamental scaling assumptions are satisfied: a comment on Valente et al	19
Informed consent for national registration of COVID-19 vaccination caused information bias of vaccine effectiveness estimates mostly in older adults: a bias correction study	19
Psychometric properties and domains covered by patient-reported outcome measures used in trials assessing interventions for chronic pain	18
Editorial Board	18
Informative statements to communicate the findings of systematic reviews of interventions: cross-cultural translation of Grading of Recommendations, Assessment, Development and Evaluation plain langua	18
An umbrella review reveals that control variables are rarely considered as a source of heterogeneity in systematic reviews of observational studies	18
Challenges with need to improve the reference standard in diagnosis: paper 2: real-world case examples from GRADE for when a reference standard is not clearly defined/ easily replicable or when it is	18
Strength of statistical evidence for the efficacy of cancer drugs: a Bayesian reanalysis of randomized trials supporting Food and Drug Administration approval	18
Characterizing updated and living meta-analyses Part 1: A methodological scoping review on methods for conducting meta-analyses in updated and living systematic reviews	18
Presentation approaches for enhancing interpretability of patient-reported outcomes in meta-analyses: a systematic survey of Cochrane reviews	18
Assessment of Standards for Reporting of Diagnostic Accuracy (STARD) 2015 guideline adherence in medical imaging diagnostic accuracy studies published in 2023	18
2,109 randomized oncology trials map continuous, meager improvements in progression-free and overall survival over 50 years	18
Table of Contents	18
The methods adopted by Autier et al do not support their conclusions	18

Response rates in email vs. mail surveys for urologists: a randomized controlled trial	18
Editorial Board	18
Table of Contents	18
Table of Contents	18
Editorial Board	17
There is a need to address uptake of core outcome sets in research and guidelines	17
Development of a refined harmonization approach for longitudinal cognitive data in people with HIV	17
Inclusion of harm outcomes in core outcome sets requires careful consideration	17
Cox regression using a calendar time scale was unbiased in simulations of COVID-19 vaccine effectiveness & safety	17
Comments, suggestions, and criticisms of the Pragmatic Explanatory Continuum Indicator Summary-2 design tool: a citation analysis	17
Epidemiology and reporting characteristics of systematic reviews of clinical prediction models: a scoping review	17
Sponsorship bias in oncology cost effectiveness analysis	17
A multistakeholder development process to prioritize and translate COVID-19 health recommendations for patients, caregivers and the public. A case study of the COVID-19 recommendation map	17
Considerations for the use of biochemical laboratory registry data in clinical and public health research	16
Methodological challenges in pilot trials of herbal medicine: barriers to evidence-based practice	16
Content validity: judging the relevance, comprehensiveness, and comprehensibility of an outcome measurement instrument – a COSMIN perspective	16
David Sackett Young Investigator Award 2021	16
Inconsistency in publishers' responses to integrity concerns about published research. Evidence and suggested improvements	16
Beyond the binary: integrating “real-world evidence” with randomized trials in contemporary health care	16
Behavior of prediction performance metrics with rare events	16
Associations of hypothetical early intensive in-hospital rehabilitation with activities of daily living after hip fracture surgery in patients with and without dementia: emulating a randomized control	16
A multifaceted graphical display, including treatment ranking, was developed to aid interpretation of network meta-analysis	16
The influence of the dynamic context of the pandemic on the predictive performance of mortality predictions over time in older patients hospitalized for COVID-19	16
Expanding the debate on real-world evidence: toward an approach focused on complementarity and methodological rigor	16
Calculating follow-up completeness: a comparison of multiple methods under different simulated scenarios and a use case	16
Exploring the use and usefulness of living guidelines for consumers: international online survey of patients' and carers' views	16
Weekly updating of guideline recommendations was feasible: the Australian National COVID-19 clinical evidence Taskforce	16
Reporting of withdrawn participants in randomized controlled trials assessing targeted therapies in immune-mediated skin diseases: a cross-sectional study of trials from systematic reviews	16
Table of Contents	15
Empirical studies of balance do not justify a requirement for 1,000 patients per trial	15
Differentiating between mapping reviews and evidence gap maps	15
Most systematic reviews that used the term “update” in title/abstract were not an updated version	15
Critical elements of synthesis questions are incompletely reported: survey of systematic reviews of intervention effects	15
The value of international collaboration	15
A review of health equity considerations in Cochrane reviews of lifestyle interventions for cardiovascular health in adults	14
Large responses to antidepressants or methodological artifacts? A secondary analysis of STAR∗D, a single-arm, open-label, nonindustry antidepressant trial	14
Paper 4: a systematic review on the use of logic models and frameworks for methodological conduct of evidence synthesis	14
Large variation existed in standardized mean difference estimates using different calculation methods in clinical trials	14
Statistical model assessment in published dose-response meta-analyses is suboptimal: evidence from a methodological review and reanalysis of 242 datasets	14
Equity issues rarely addressed in the development of COVID-19 formal recommendations and good practice statements: a cross-sectional study	14
Researcher-patient partnership generated actionable recommendations, using quantitative evaluation and deliberative dialogue, to improve meaningful engagement	14
Comparative effectiveness research considered methodological insights from simulation studies in physician's prescribing preference	14
Methods for living guidelines: early guidance based on practical experience. Paper 3: selecting and prioritizing questions for living guidelines	14
Estimates of sensitivity and specificity of serological tests for SARS-CoV-2 specific antibodies using a Bayesian latent class model approach	14
Persistent ethnic disparities in authorship within top European and North American medical journals: a serial cross-sectional analysis	14
Geriatric impairments were directly and indirectly associated with mortality in older patients with cancer: a structural equation analysis	14
Funding matters: time to update preferred reporting items for systematic reviews and meta-analyses?	14
Variation observed in consensus judgments between pairs of reviewers when assessing the risk of bias due to missing evidence in a sample of published meta-analyses of nutrition research	14
Paper 2: themes from semistructured interviews	14
Introducing article numbering to Journal of Clinical Epidemiology	13
What should journals do to prevent the publication of methodologically flawed systematic reviews?	13
Decision criteria for selecting essential medicines and their connection to guidelines: an interpretive descriptive qualitative interview study	13
Handling missing patient-reported outcomes in longitudinal clinical trials: a simulation study	13
Methods for developing diagnostic criteria for conditions without objective tests, biomarkers, or reference standards: a scoping review	13
High certainty evidence is stable and trustworthy, whereas evidence of moderate or lower certainty may be equally prone to being unstable	13
“How-to”: scoping review?	13
The use of the E-value for sensitivity analysis	13
Editorial Board	13
Retracted randomized controlled trials were cited and not corrected in systematic reviews and clinical practice guidelines	13
Comparison between risk of bias-1 and risk of bias-2 tool and impact on network meta-analysis results—A case study from a living Cochrane review on psoriasis	13
Individual patient data meta-analysis estimates the minimal detectable change of the Geriatric Depression Scale-15	13
Misusing I2 for inconsistency, overlooking OIS for imprecision, and ignoring the continuum of certainty ratings: common pitfalls in GRADE assessments	13
Minimal important change was on the lower spectrum of previous estimates and responsiveness was sufficient for core outcomes in chronic low back pain	13
Data quality assessment of interventional trials in public trial databases	13
The complexity of the relationship between ethnicity and COVID-19 outcomes: author's reply	13
Quality of surgical patient-reported outcome measure validation studies is often deficient: a systematic review	13
The importance of reporting computed tomography scan intervals in real-world oncology studies: a simulation analysis of afatinib in advanced-stage non-small cell lung cancer	13
Prospective registration was associated with a reduced risk of bias for randomized controlled trials: a meta-research study	13
An exploratory descriptive survey on the use of GRADE and CINeMA: time-consuming, process transparency and subjectivity vs high-speed, practical challenges, and poor understanding	13
Meta-research studies should improve and evaluate their own data sharing practices	13
Increased endorsement of TRIPOD and other reporting guidelines by high impact factor journals: survey of instructions to authors	13
Assessing conflict of interest reporting and quality of clinical trials on infant formula: a systematic review	12
Recruitment and implementation challenges were common in stepped-wedge cluster randomized trials: Results from a methodological review	12
Persistent gender disparity in leading dental publications across 4 decades: an observational study	12
Complete case logistic regression with a dichotomised continuous outcome led to biased estimates	12
Indirect effects in mediation analyses should not be tested for statistical significance	12
The need for further guidance on the handling of multiple outcomes in randomized controlled trials: a scoping review of the methodological literature	12
Prevalence of patient and public involvement in child health randomized controlled trials and impact on research quality, loss to follow-up, and dissemination	12
Patient preference trials in oncology: a scoping review and recommendations on reporting	12
Reusing clinical trial data to consolidate and advance medical knowledge	12
Paper 6: engaging racially and ethnically diverse interest holders in evidence syntheses	12
Update of the agency for healthcare research and quality guidance on using nonrandomized studies in evidence syntheses	12
Existing research guidelines for inclusive trials methodology. Working toward the integration of qualitative research, equity, diversity, and inclusion and trials methodology: a focused mapping review	12
Equating and linking Patient-Reported Outcomes Measurement Information System 29-item questionnaire and 36-item Short-Form Health Survey domains using Rasch modeling	12
Applying calculations to clinical medicine requires nuance: response to Uy	12
Empirical estimation of disutilities and decision thresholds for composite endpoints	12
Guideline organizations' guidance documents paper 2: priority setting	12
Editors’ Choice January 2026	12
Text message incentives increased patient-reported outcomes survey response in emergency care: SWAT findings	12
Published registry-based pharmacoepidemiologic associations show limited concordance with agnostic medication-wide analyses	12
Potential waste in evidence synthesis for health screening: a scoping review and call for action	12
We extended the 2-week systematic review (2weekSR) methodology to larger, more complex systematic reviews: A case series	12
Sequential sample size calculations and learning curves safeguard the robust development of a clinical prediction model for individuals	11
A comparison of five statistical methods used to analyse longitudinal EORTC QLQ-C30 quality of life scores in randomised controlled trials: a simulation study	11
Analysis of risk of bias assessments in a sample of intervention systematic reviews, Part II: focus on risk of bias tools reveals few meet current appraisal standards	11