Journal of Clinical Epidemiology

Article	Citations
Visualizing the value of diagnostic tests and prediction models, part III. Numerical example with discrete risk groups and miscalibration	313
Meta-analysis of individual participant data and informed consent: a small step, but important and neglected	250
Guideline organizations’ guidance documents paper 10: developing recommendations about diagnostic tests and strategies	210
Empirical evaluation of the methods used in systematic reviews including observational studies and randomized trials	205
Strong and high-quality evidence synthesis needs Cochrane: a statement of support by the GRADE Guidance Group	152
Editorial Board	135
The construct of certainty of evidence has not been disseminated to systematic reviews and clinical practice guidelines; response to ‘The GRADE Working Group’ et al	128
A general explanation of the counterfactual definition of confounding	126
Use of artificial intelligence to support the assessment of the methodological quality of systematic reviews	118
Harms were detected but not reported in six clinical trials of gabapentin	117
Statistical robustness of randomized controlled trials in high-impact journals has improved but was low across medical specialties	116
Corrigendum to ‘Identifying type 1 and 2 diabetes in research datasets where classification biomarkers are unavailable: assessing the accuracy of published approaches’ [Journal of Clinical Epidemiolog	115
Reporting of funding and conflicts of interest improved from preprints to peer-reviewed publications of biomedical research	99
Pharmacovigilance studies without a priori hypothesis: systematic review highlights inappropriate multiple testing correction procedures	97
Advances in methodologies of negative controls: a scoping review	95
Screening colonoscopy similarly prevented distal and proximal colorectal cancer: a prospective study among 55–69-year-olds	95
A Bayesian-adaptive decision-theoretic approach can reduce the sample sizes for multiarm exercise oncology trials	92
RETRACTED: Part II: a step-by-step guide to latent class analysis	87
Integrating personomics into precision medicine	84
Types and associated methodologies of overviews of reviews in health care: a methodological study with published examples	80
Measuring the environmental impact of health interventions in randomized controlled trials – A scoping review	79
External validation, impact assessment and clinical utilization of clinical prediction models: a prospective cohort study	78
Predicting COVID-19 prognosis in the ICU remained challenging: external validation in a multinational regional cohort	75
External validation of six COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting	67
Evaluation of tools used to assess adherence to PRISMA 2020 reveals inconsistent methods and poor tool implementability: part I of a systematic review	61

Potential interactions between digoxin and direct oral anticoagulants: application of cohort & novel case-crossover designs	61
Two-decade health-related quality of life and performance on physical function tests in midaged women: findings from a prospective cohort study	61
Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence	61
The walking man approach to interpreting the receiver operating characteristic curve and area under the receiver operating characteristic curve	60
Results reporting for clinical trials led by medical universities and university hospitals in the nordic countries was often missing or delayed	57
JBI series paper 2: tailored evidence synthesis approaches are required to answer diverse questions: a pragmatic evidence synthesis toolkit from JBI	56
Librarian involvement in systematic reviews was associated with higher quality of reported search methods: a cross-sectional survey	56
GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses	56
Searching two or more databases decreased the risk of missing relevant studies: a metaresearch study	53
Handling missing data in clinical research	52
Methodological use and report of AMSTAR 2: a cross-sectional study	52
Table of Contents	51
Editors' Choice September 2024	50
Editors’ Choice: October 2024	49
The World Conference on Research Integrity 2024	47
Methodological quality assessment tools for diagnosis and prognosis research: overview and guidance	46
Heterogeneity across outcomes reported in clinical trials for older adults with depression: a systematic survey	45
Maternal early warning scores shown to be methodologically weak and at high risk of bias	45
Year-to-year variation in attack rates could result in underpowered respiratory syncytial virus vaccine efficacy trials	44
Is it time for a common peer review format for biomedical journals?	44
A population-based recalibration method for updating survival neural networks models for cardiovascular risk prediction in United Kingdom and China	43
The performance of three nutritional tools varied in colorectal cancer patients: a retrospective analysis	42
Improved reporting of selection processes in clinical database research: author's reply	42
Table of Contents	42
Controversy and debate: challenges with the need to improve the reference standard in diagnosis paper 1: two challenges: absence of a clear cut, easily replicable test for the reference standard; unet	40
Table of Contents	40
Response to “Homeopathy: A null field or effective psychotherapy?”	39
Prevalence of and factors associated with potentially redundant randomized controlled trials: a cross-sectional study	39
Meta-analysis of multi-jurisdictional health administrative data from distributed networks approximated individual-level multivariable regression	38
A method was developed for correcting the bias in the usual study weights in meta-analyses	38
Incorporating postmenopausal women's perspectives into osteoporosis clinical guidelines: a systematic review	37
Many systematic reviews with a single author are indexed in PubMed	37
A call for methodological guidance to support initiatives to develop diagnostic criteria for conditions without reference standard diagnostic tests	36
Indirectness (transferability) is critical when considering existing economic evaluations for GRADE clinical practice guidelines: a systematic review	36
Conflict of interest policies for editors and peer reviewers in medical journals: cross-sectional study	36
Priority-setting criteria for clinical practice guideline development on rare genetic neurodevelopmental disorders: a Delphi study within the European Reference Network ITHACA	35
Editorial Board	34
Promoting responsible scientific research: integrating retractions into the ORCID profile	34
Resourcing and validation of the GRADE ontology: reply to Dedeepya et al.	33
Improving grading of recommendations assessment, development, and evaluation evidence tables part 4: a three-arm noninferiority randomized trial demonstrates improved understanding of content in summa	33
A multimethods randomized trial found that plain language versions improved parents’ understanding of health recommendations	32
Item response theory may account for unequal item weighting and individual-level measurement error in trials that use PROMs: a psychometric sensitivity analysis of the TOPKAT trial	32
Avoiding overadjustment bias in social epidemiology through appropriate covariate selection: a primer	32
Predictors of citation rates and the problem of citation bias: a scoping review	32
Consistency of protocol and safety data reporting in clinical trial registrations and corresponding publications of interventions involving MDMA and psilocybin	31
Editors' Choice - July 2023	30
Surrogate endpoint metaregression: useful statistics for regulators and trialists	30
Qualitative study of guideline panelists: innovative surveys provided valuable insights regarding patient values and preferences	30
Re: living recommendations do not ‘flip-flop’ - Examining the probability of directional changes to recommendations in living guidelines	29
Editorial Board	29

A framework for evaluating predictive models	29
Editors’ Choice January 2025	28
Characteristics and completeness of reporting of systematic reviews of prevalence studies in adult populations: a metaresearch study	27
Guideline organizations’ guidance documents paper 4: interest-holder engagement	27
Use of clustering techniques for clinical and epidemiological research: practical tips using an example from rheumatology	27
The impact of climate change on health needs structured evidence assessment and an evidence to action framework to make decisions: a proposal to adopt the GRADE approach	27
Use of participant data and biological samples is insufficiently described in participant information leaflets	27
A metaresearch study finds unclear impact of institutional conflicts of interest on conclusions of studies investigating volume–outcome relationships	27
Reply: A needed evolution in GRADE to address dissemination (publication) bias	27
Including nonrandomized studies of interventions in systematic reviews: principles and practicalities	26
Accounting for differential exclusions in the Nordic-European initiative on colorectal cancer trial discloses stronger-than-reported effects of screening colonoscopy	26
Validation of the Persistent Somatic Symptom Stigma Scale for Healthcare Professionals	26
Incorporating non-randomized evidence in cochrane intervention reviews: a scoping review	26
Systematic review of multivariable prognostic models for outcomes at least 30 days after hip fracture finds 18 mortality models but no nonmortality models warranting validation	26
Methods for living guidelines: early guidance based on practical experience. Paper 5: decisions on methods for evidence synthesis and recommendation development for living guidelines	25
In a pilot study, automated real-time systematic review updates were feasible, accurate, and work-saving	25
Implementing a randomization consent to enable Trials within Cohorts in the Swiss HIV Cohort Study – A mixed-methods study	25
Health state utility differed systematically in breast cancer patients between the EORTC QLU-C10D and the PROMIS Preference Score	25
Assessing the scientific integrity of the collected work of one author or author group	25
A new taxonomy is proposed for defining the interests of stakeholders’ representatives in health research: the case of guideline development	24
Including conference abstracts rarely changed systematic review conclusions: a case study from a living network meta-analysis of COVID-19 treatments	24
Regulatory context for protocol amendments and public reporting in psychedelic trials	24
A methodological review of network meta-analyses applied to complex interventions for public health and a typology of the node-making process	24
GRADE guidance 36: updates to GRADE's approach to addressing inconsistency	24
Defining decision thresholds for judgments on health benefits and harms using the grading of recommendations assessment, development, and evaluation (GRADE) evidence to decision (EtD) frameworks: a ra	24
Part I: A friendly introduction to latent class analysis	24
Editors’ Choice: June 2026	24
Prevalence of patient partner authorship and acknowledgment in child health research publications: an umbrella review	23
Gynecological trials frequently exclude people based on their symptoms rather than their condition: a systematic review of Cochrane reviews and their component trials	23
Author’s reply: “The importance of properly specifying your target trial emulation: commentary on Mésidor et al.”	23
Answers to comments by Jonas Schmidt, Casper Urth Pedersen, and Sisse Helle Njor	23
New research questions identified for Cochrane reviews: a cross-sectional study of a specialized register: part two: fertility	23
13-Year colorectal cancer risk after lower-quality, higher-quality and no screening colonoscopy: a cohort study	23
AMSTAR 2 is only partially applicable to systematic reviews of non-intervention studies: a meta-research study	23
Reporting of health equity considerations in vaccine trials for COVID-19: a methodological review	23
Developing and externally validating multinomial prediction models for methotrexate treatment outcomes in patients with rheumatoid arthritis: results from an international collaboration	22
Patient-reported outcomes and measures are under-utilised in advanced therapy medicinal products trials for orphan conditions	22
Mapping intersectional sociodemographic inequalities in measurement and prevalence of depressive symptoms: a intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy	22
Implementation of a dynamic model updating pipeline provides a systematic process for maintaining performance of prediction models	22
Statistical strategies to analyze local control after radiotherapy	22
Toward an observatory of the evolution of clinical trials through phylomemy reconstruction: the COVID-19 vaccines example	22
AI-enabled exploitation of open science: a response to Zil-E-Ali on safeguarding data research integrity	22
Joint modeling of endpoints can be used to answer various research questions in randomized clinical trials	22
Editorial, April 2025	22
Peer review reports of randomized controlled trials in oncology can be short and superficial	22
Underserved groups remain underserved as eligibility criteria routinely exclude them from breast cancer trials	22
Pain and physical function are common core domains across 40 core outcome sets of musculoskeletal conditions: a systematic review	21
Gastrointestinal prophylaxis for COVID-19: an illustration of severe bias arising from inappropriate comparators in observational studies	21
Ratios are misleading exposure variables that compromise a regression model unless fundamental scaling assumptions are satisfied: a comment on Valente et al	21
Reply to “Some additional considerations on the evidence for fluoxetine in pediatric depression”	21
Psychometric properties and reference values for the instrumented timed-up and go test in adults	21
Flexible approaches to clinical trials	21
A scoping review of the assessment reports of genetic or genomic tests reveals inconsistent consideration of key dimensions of clinical utility	21
The use of guidelines in multimorbidity-related practice: an exploratory questionnaire survey	21
Validation and impact of algorithms for identifying variables in observational studies of routinely collected data	20
Informed consent for national registration of COVID-19 vaccination caused information bias of vaccine effectiveness estimates mostly in older adults: a bias correction study	20
Adapting World Health Organization COVID-19 living guidelines balancing methodological rigor with efficiency and flexibility: a case study from Argentina	20
No short-term mortality from benzodiazepine use post-acute ischemic stroke after accounting for bias	20
Missing PRO data replacements require clearer models and mechanisms	20
The role of scoping reviews in guideline development	19
Psychometric properties and domains covered by patient-reported outcome measures used in trials assessing interventions for chronic pain	19
Broadening the scope of meta-research: from methodologists to interest-holders	19
Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis	19
Table of Contents	19
The methods adopted by Autier et al do not support their conclusions	18
Response rates in email vs. mail surveys for urologists: a randomized controlled trial	18
Editorial Board	18
Generative artificial intelligence and academic writing: friend or foe?	18
Editorial Board	18
Assessment of Standards for Reporting of Diagnostic Accuracy (STARD) 2015 guideline adherence in medical imaging diagnostic accuracy studies published in 2023	18
Exploring the use and usefulness of living guidelines for consumers: international online survey of patients' and carers' views	18
When the example used does not justify the conclusions drawn	18
Presentation approaches for enhancing interpretability of patient-reported outcomes in meta-analyses: a systematic survey of Cochrane reviews	18
Strength of statistical evidence for the efficacy of cancer drugs: a Bayesian reanalysis of randomized trials supporting Food and Drug Administration approval	18
Informative statements to communicate the findings of systematic reviews of interventions: cross-cultural translation of Grading of Recommendations, Assessment, Development and Evaluation plain langua	18
2,109 randomized oncology trials map continuous, meager improvements in progression-free and overall survival over 50 years	17
Table of Contents	17
A multistakeholder development process to prioritize and translate COVID-19 health recommendations for patients, caregivers and the public. A case study of the COVID-19 recommendation map	17
Comments, suggestions, and criticisms of the Pragmatic Explanatory Continuum Indicator Summary-2 design tool: a citation analysis	17
Inclusion of harm outcomes in core outcome sets requires careful consideration	17

Epidemiology and reporting characteristics of systematic reviews of clinical prediction models: a scoping review	17
Table of Contents	17
Table of Contents	17
Sponsorship bias in oncology cost effectiveness analysis	17
Behavior of prediction performance metrics with rare events	17
An umbrella review reveals that control variables are rarely considered as a source of heterogeneity in systematic reviews of observational studies	17
Challenges with need to improve the reference standard in diagnosis: paper 2: real-world case examples from GRADE for when a reference standard is not clearly defined/ easily replicable or when it is	17
Editorial Board	17
There is a need to address uptake of core outcome sets in research and guidelines	17
Cox regression using a calendar time scale was unbiased in simulations of COVID-19 vaccine effectiveness & safety	17
Methodological challenges in pilot trials of herbal medicine: barriers to evidence-based practice	16
A multifaceted graphical display, including treatment ranking, was developed to aid interpretation of network meta-analysis	16
Content validity: judging the relevance, comprehensiveness, and comprehensibility of an outcome measurement instrument – a COSMIN perspective	16
Calculating follow-up completeness: a comparison of multiple methods under different simulated scenarios and a use case	16
Development of a refined harmonization approach for longitudinal cognitive data in people with HIV	16
Assessing the trustworthiness of health guidelines recommendations: the Transparent, Rigorous, Usable, Standardised and Trustworthy Guide (TRUSTGUIDES) tools development	16
The influence of the dynamic context of the pandemic on the predictive performance of mortality predictions over time in older patients hospitalized for COVID-19	16
Considerations for the use of biochemical laboratory registry data in clinical and public health research	16
Weekly updating of guideline recommendations was feasible: the Australian National COVID-19 clinical evidence Taskforce	16
Beyond the binary: integrating “real-world evidence” with randomized trials in contemporary health care	16
Inconsistency in publishers' responses to integrity concerns about published research. Evidence and suggested improvements	16
Associations of hypothetical early intensive in-hospital rehabilitation with activities of daily living after hip fracture surgery in patients with and without dementia: emulating a randomized control	16
David Sackett Young Investigator Award 2021	15
Most systematic reviews that used the term “update” in title/abstract were not an updated version	15
Expanding the debate on real-world evidence: toward an approach focused on complementarity and methodological rigor	15
The value of international collaboration	15
Automated evidence surveillance with AI-enabled pre-ranking with cutoff in living guideline maintenance: a simulation study	15
Empirical studies of balance do not justify a requirement for 1,000 patients per trial	15
Differentiating between mapping reviews and evidence gap maps	14
Decision criteria for selecting essential medicines and their connection to guidelines: an interpretive descriptive qualitative interview study	14
A review of health equity considerations in Cochrane reviews of lifestyle interventions for cardiovascular health in adults	14
High certainty evidence is stable and trustworthy, whereas evidence of moderate or lower certainty may be equally prone to being unstable	14
Meta-research studies should improve and evaluate their own data sharing practices	14
Critical elements of synthesis questions are incompletely reported: survey of systematic reviews of intervention effects	14
Data quality assessment of interventional trials in public trial databases	14
Equity issues rarely addressed in the development of COVID-19 formal recommendations and good practice statements: a cross-sectional study	14
Table of Contents	14
Persistent ethnic disparities in authorship within top European and North American medical journals: a serial cross-sectional analysis	14
Large responses to antidepressants or methodological artifacts? A secondary analysis of STAR∗D, a single-arm, open-label, nonindustry antidepressant trial	14
Geriatric impairments were directly and indirectly associated with mortality in older patients with cancer: a structural equation analysis	14
Prospective registration was associated with a reduced risk of bias for randomized controlled trials: a meta-research study	13
Methods for living guidelines: early guidance based on practical experience. Paper 3: selecting and prioritizing questions for living guidelines	13
Evaluating the Integration of the Reported Treatment Mechanisms and Goal of Treatment in Randomized Controlled Trials for Low Back Pain: Protocol for a Meta-Epidemiological Analysis	13
Paper 2: themes from semistructured interviews	13
Variation observed in consensus judgments between pairs of reviewers when assessing the risk of bias due to missing evidence in a sample of published meta-analyses of nutrition research	13
The importance of reporting computed tomography scan intervals in real-world oncology studies: a simulation analysis of afatinib in advanced-stage non-small cell lung cancer	13
Comparative effectiveness research considered methodological insights from simulation studies in physician's prescribing preference	13
Increased endorsement of TRIPOD and other reporting guidelines by high impact factor journals: survey of instructions to authors	13
An exploratory descriptive survey on the use of GRADE and CINeMA: time-consuming, process transparency and subjectivity vs high-speed, practical challenges, and poor understanding	13
The use of the E-value for sensitivity analysis	13
“How-to”: scoping review?	13
Methods for developing diagnostic criteria for conditions without objective tests, biomarkers, or reference standards: a scoping review	13
Paper 4: a systematic review on the use of logic models and frameworks for methodological conduct of evidence synthesis	13
Researcher-patient partnership generated actionable recommendations, using quantitative evaluation and deliberative dialogue, to improve meaningful engagement	13
Retracted randomized controlled trials were cited and not corrected in systematic reviews and clinical practice guidelines	13
Misusing I2 for inconsistency, overlooking OIS for imprecision, and ignoring the continuum of certainty ratings: common pitfalls in GRADE assessments	13
Large variation existed in standardized mean difference estimates using different calculation methods in clinical trials	13
Statistical model assessment in published dose-response meta-analyses is suboptimal: evidence from a methodological review and reanalysis of 242 datasets	13
Funding matters: time to update preferred reporting items for systematic reviews and meta-analyses?	13
Estimates of sensitivity and specificity of serological tests for SARS-CoV-2 specific antibodies using a Bayesian latent class model approach	13
Handling missing patient-reported outcomes in longitudinal clinical trials: a simulation study	12
Methodological approaches for developing, reporting, and assessing evidence-based clinical practice guidelines: a systematic survey	12
Introducing article numbering to Journal of Clinical Epidemiology	12
Prevalence of patient and public involvement in child health randomized controlled trials and impact on research quality, loss to follow-up, and dissemination	12
Guideline organizations' guidance documents paper 2: priority setting	12
Sequential sample size calculations and learning curves safeguard the robust development of a clinical prediction model for individuals	12
The smallest worthwhile effect is superior to the MCID for estimating acceptable benefits of knee arthroplasty	12
Individual patient data meta-analysis estimates the minimal detectable change of the Geriatric Depression Scale-15	12
Comparison between risk of bias-1 and risk of bias-2 tool and impact on network meta-analysis results—A case study from a living Cochrane review on psoriasis	12
Editorial Board	12
Published registry-based pharmacoepidemiologic associations show limited concordance with agnostic medication-wide analyses	12
Quality of surgical patient-reported outcome measure validation studies is often deficient: a systematic review	12
Editors’ Choice January 2026	12
The challenges and opportunities of artificial intelligence and their impact on the journal	12
Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed	12
Minimal important change was on the lower spectrum of previous estimates and responsiveness was sufficient for core outcomes in chronic low back pain	12
The complexity of the relationship between ethnicity and COVID-19 outcomes: author's reply	12
Recruitment and implementation challenges were common in stepped-wedge cluster randomized trials: Results from a methodological review	12
Applying calculations to clinical medicine requires nuance: response to Uy	12
What should journals do to prevent the publication of methodologically flawed systematic reviews?	12
Assessing conflict of interest reporting and quality of clinical trials on infant formula: a systematic review	12
Update of the agency for healthcare research and quality guidance on using nonrandomized studies in evidence syntheses	12
The need for further guidance on the handling of multiple outcomes in randomized controlled trials: a scoping review of the methodological literature	11
We extended the 2-week systematic review (2weekSR) methodology to larger, more complex systematic reviews: A case series	11
Key considerations for planning adaptive platform trials: part 1	11
Patient preference trials in oncology: a scoping review and recommendations on reporting	11
Empirical estimation of disutilities and decision thresholds for composite endpoints	11
Reusing clinical trial data to consolidate and advance medical knowledge	11
Text message incentives increased patient-reported outcomes survey response in emergency care: SWAT findings	11
Understanding variation in the results of real-world evidence studies that seem to address the same question	11
Potential waste in evidence synthesis for health screening: a scoping review and call for action	11
No evidence of important difference in summary treatment effects between COVID-19 preprints and peer-reviewed publications: a meta-epidemiological study	11
Equating and linking Patient-Reported Outcomes Measurement Information System 29-item questionnaire and 36-item Short-Form Health Survey domains using Rasch modeling	11
Conceptualizing, operationalizing, and utilizing equity, diversity, and inclusion in clinical trials: a scoping review	11
A systematic review to identify how children and young people were included in the development of pediatric core outcome sets	11