OOIR: Observatory of International Research

Papers

(The TQCC of Chemical Research in Toxicology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Issue Publication Information	161
Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation	81
Issue Editorial Masthead	63
Organophosphorus Pesticides Promote Protein Cross-Linking	62
Genetically Encoded Fluorescent Redox Indicators for Unveiling Redox Signaling and Oxidative Toxicity	53
Issue Publication Information	52
Correction to “Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice”	50
Mass Spectrometric Quantitation of N′-Nitrosonornicotine-1N-oxide in the Urine of Cigarette Smokers and Smokeless Tobacco Users	49
Environmental Stability Determines the Cytotoxicity of Metal–Organic Frameworks to a Nitrogen-Fixing Bacterium Azotobacter vinelandii	49
Issue Editorial Masthead	48
Issue Publication Information	47
Issue Publication Information	47
Systematic Approaches for the Encoding of Chemical Groups: A Case Study	40
Special Issue on Tobacco: Chemistry, Mechanisms, Biomarkers and Disease Prevention	39
Issue Editorial Masthead	39
Issue Publication Information	37
Metals Come in Many Flavors–Is Inference about the Health Effects of Tattoo Inks Based on the Analysis of Inorganic Elements Justified?	35
Correction to “Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA Adductomics”	33
Letter to the Editor Regarding Benzophenone Accumulates over Time from the Degradation of Octocrylene in Commercial Sunscreen Products	33
Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs	33
miR133b Microinjection during Early Development Targets Transcripts of Cardiomyocyte Ion Channels and Induces Oil-like Cardiotoxicity in Zebrafish (Danio rerio) Embryos	32
In Vitro and In Vivo Analysis of Fentanyl and Fentalog Metabolites using Hyphenated Chromatographic Techniques: A Review	31
Prediction and Structure–Activity Relationship Analysis on Ready Biodegradability of Chemical Using Machine Learning Method	31
Issue Publication Information	30
Correction to DNA Polymerase II Supports the Replicative Bypass of N²-Alkyl-2′-deoxyguanosine Lesions in Escherichia coli Cells	29

Reply to the Comment on Critical Choices in Predicting Stone Wool Biodurability: Lysosomal Fluid Compositions and Binder Effects	29
Issue Publication Information	28
Pancreatic INS-1 β-Cell Response to Thapsigargin and Rotenone: A Comparative Proteomics Analysis Uncovers Key Pathways of β-Cell Dysfunction	27
Issue Editorial Masthead	27
Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response	26
Antidepressant Actions of Ketamine: Potential Role of L-Type Calcium Channels	25
Zebrafish Oatp1d1 Acts as a Cellular Efflux Transporter of the Anionic Herbicide Bromoxynil	25
Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction	25
Multiplatform Metabolomics to Understand the Imidacloprid-Induced Toxicity in Drosophila	24
Human CYP2C19 Substrate and Inhibitor Characterization of Organophosphate Pesticides	24
Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating CD36 Upregulation	23
Machine Learning Enables Accurate Prediction of Quinone Formation during Drug Metabolism	22
Correction to “Structural and Mechanistic Investigation of the Unusual Metabolism of Nifurtimox”	22
Issue Publication Information	21
Heterogeneity of Harmful Constituent Profiles in Smokeless Tobacco Products from Five African Countries	21
Detrimental Role of CXCR3 in α-Naphthylisothiocyanate- and Triptolide-Induced Cholestatic Liver Injury	20
Issue Editorial Masthead	20
Identification of Tellurium Metabolite in Broccoli Using Complementary Analyses of Inorganic and Organic Mass Spectrometry	19
Dissecting the Enantioselective Neurotoxicity of Isocarbophos: Chiral Insight from Cellular, Molecular, and Computational Investigations	19
Effects of E-Cigarette Flavor Enhancing Capsules on Inhalable Aerosols	18
In Vitro and In Vivo Metabolic Activation and Hepatotoxicity of Environmental Pollutant 2,6-Dimethylphenol	18
A New Explanation for the Mystery of Rasputin’s Survival of Cyanide Poisoning: Eating Raw Garlic	18
Toxicoproteomics of Mono(2-ethylhexyl) phthalate and Perfluorooctanesulfonic Acid in Models of Prostatic Diseases	18
Issue Editorial Masthead	18
Exploring the Cellular Impact of Size-Segregated Cigarette Aerosols: Insights into Indoor Particulate Matter Toxicity and Potential Therapeutic Interventions	18
Theoretical Validation of In Chemico Skin Sensitization Assay “ADRA” Using the Products Formed by Nucleophilic Reagents and Chemicals	17
Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor	17
Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors	17
Issue Editorial Masthead	17
Use of Solvent Mapping for Characterizing the Binding Site and for Predicting the Inhibition of the Human Ether-á-Go-Go-Related K⁺ Channel	17
Automated Solid-Phase Microextraction and Negative Chemical Ionization GC-MS for the Measurement of Synthetic Pyrethroids	16
Issue Publication Information	16
Induction of Protective Response Associated with Expressional Alterations in Neuronal G Protein-Coupled Receptors in Polystyrene Nanoparticle Exposed Caenorhabditis elegans	16
Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ_1–42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells	16
Correction to The Impact of the COVID-19 Pandemic on the Future of Science Careers	16
Investigation of 2′-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N′-Nitrosonornicotine Metabolism	16
Issue Publication Information	16
Recent Advances in DNA Lesion Mapping and Repair Mechanisms	16
LA-ICP-MS and Immunohistochemical Staining with Lanthanide-Labeled Antibodies to Study the Uptake of CeO₂ Nanoparticles by Macrophages in Tissue Sections	16
Transcription Factor ELF1 Modulates Cisplatin Sensitivity in Prostate Cancer by Targeting MEIS Homeobox 2	15
Carbonyls and Aerosol Mass Generation from Vaping Nicotine Salt Solutions Using Fourth- and Third-Generation E-Cigarette Devices: Effects of Coil Resistance, Coil Age, and Coil Metal Material	15
Development of a Liquid Chromatography–Mass Spectrometry-Based In Vitro Assay to Assess Changes in Steroid Hormones Due to Exposure to Per- and Polyfluoroalkyl Substances	15
New Synthetic Analogs of Nitrogen Mustard DNA Interstrand Cross-Links and Their Use to Study Lesion Bypass by DNA Polymerases	15
Cystine/Glutamate Xc^– Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathion	15
Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans	15
An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Conce	14
MicroRNA Expression Influences Methylmercury-Induced Lipid Accumulation and Mitochondrial Toxicity in Caenorhabditis elegans	14
Nonclinical Evaluation of Antibacterial Oxazolidinones Contezolid and Contezolid Acefosamil with Low Serotonergic Neurotoxicity	14
Cannabis Vaping: Existing and Emerging Modalities, Chemistry, and Pulmonary Toxicology	14
Increased Levels of the Acrolein Metabolite 3-Hydroxypropyl Mercapturic Acid in the Urine of e-Cigarette Users	14

Examining the Oxidation States of Metals in Aerosols Emitted by Electronic Cigarettes	14
Amino Reactivity of Glutardialdehyde and Monoaldehydes─Chemoassay Profile vs Skin Sensitization Potency	14
Carrier Solvents of Electronic Nicotine Delivery Systems Alter Pulmonary Surfactant	14
Response to the Letter to the Editor by Dr. Christian Surber	14
The Dawn of a New Era in Drug Discovery? Drug Screening and the Increasing Biological Complexity of Testing Models	14
Role of Particulate Matter from Afghanistan and Iraq in Deployment-Related Lung Disease	14
Protein Haptenation and Its Role in Allergy	14
Novel Processes Associated with the Repair of Interstrand Cross-Links Derived from Abasic Sites in Duplex DNA: Roles for the Base Excision Repair Glycosylase NEIL3 and the SRAP Protein HMCES	14
Oxidative Deformylation of the Predominant DNA Lesion 5-Formyl-2′-deoxyuridine	14
Nicotinamide riboside Induced Energy Stress and Metabolic Reprogramming in BEAS-2B Cells	13
Mass Spectrometric Detection and Differentiation of Enzymatically Active Abrin and Ricin Combined with a Novel Affinity Enrichment Technique	13
O⁶-Alkylguanine-DNA Alkyltransferase Maintains Genome Integrity by Forming DNA–Protein Cross-Links during Inflammation-Associated Peroxynitrite-Mediated DNA Damage	13
Identification of an Epoxide Metabolite of Amitriptyline In Vitro and In Vivo	13
Antioxidant Activity and Skin Sensitization of Eugenol and Isoeugenol: Two Sides of the Same Coin?	13
Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides	13
The Amyloid Aggregation Accelerator Diacetyl Prevents Cognitive Decline in Alzheimer’s Mouse Models	13
Identification of Formaldehyde-Induced DNA–RNA Cross-Links in the A/J Mouse Lung Tumorigenesis Model	13
Unraveling Interspecies Differences in the Phase I Hepatic Metabolism of Alternariol and Alternariol Monomethyl Ether: Closing Data Gaps for a Comprehensive Risk Assessment	13
Chronic Exposure to Climbazole Induces Oxidative Stress and Sex Hormone Imbalance in the Testes of Male Zebrafish	13
The Selective SIRT3 Inhibitor 3-TYP Represses Primary Myeloma Growth by Reducing c-Myc Stability	13
Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity	13
Autophagy Plays a Protective Role in Sodium Hydrosulfide-Induced Acute Lung Injury by Attenuating Oxidative Stress and Inflammation in Rats	13
Inhibition of UVA Damage on Human Skin Dermis Fibroblasts by the Isoflavonoid Intermediate Deoxybenzoin-3A	13
Cellular Interactions and Fatty Acid Transporter CD36-Mediated Uptake of Per- and Polyfluorinated Alkyl Substances (PFAS)	13
A Wide Range of Flavoring–Carrier Fluid Adducts Form in E-Cigarette Liquids	13
Computational Approach to Link Chemicals in Anthropogenic Smoke Particulate Matter with Toxicity	13
Cel-CS1K: A Celastrol–Chitosan Conjugate for Treating Diet-Induced Obesity	13
Pathogenic and Commensal Gut Bacteria Harboring Glycerol/Diol Dehydratase Metabolize Glycerol and Produce DNA-Reactive Acrolein	13
Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies	13
Electrochemical Simulation of the Oxidative Capsaicin Metabolism	13
In Vitro Glucuronidation of Caribbean Ciguatoxins in Fish: First Report of Conjugative Ciguatoxin Metabolites	12
Probing the Hidden Role of Mitochondrial DNA Damage and Dysfunction in the Etiology of Aristolochic Acid Nephropathy	12
Short-Term Exposure to Foodborne Xenoestrogens Affects Breast Cancer Cell Morphology and Motility Relevant for Metastatic Behavior In Vitro	12
The Intercalator Ethidium Bromide Generates Covalent Adducts at Apurinic/Apyrimidinic Sites in DNA	12
Metabolic and Lipid Alterations in Mice Brain Cortex after PM_2.5 Exposure	12
Mechanistic Insights into Toxicity of Titanium Dioxide Nanoparticles at the Micro- and Macro-levels	12
Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice	12
Updating Reaction Mechanistic Domains for Skin Sensitization: 1. Nucleophilic Skin Sensitizers	12
Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O⁶-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presen	12
Current Challenges to Align Inflammatory Key Events in Animals and Lung Cell Models In Vitro	12
In Vitro Screening for ToxCast Chemicals Binding to Thyroxine-Binding Globulin	12
Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19	11
Coumarin-Based Noncytotoxicity Fluorescent Dye for Tracking Actin Protein in In-Vivo Imaging	11
Alternaria alternata Mycotoxins Activate the Aryl Hydrocarbon Receptor and Nrf2-ARE Pathway to Alter the Structure and Immune Response of Colon Epithelial Cells	11
Advances in Smoking Related In Vitro Inhalation Toxicology: A Perspective Case of Challenges and Opportunities from Progresses in Lung-on-Chip Technologies	11
Chemistry, Pharmacology, and Toxicology of Monoisoamyl Dimercaptosuccinic Acid: A Chelating Agent for Chronic Metal Poisoning	11
Structure–Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity	11
Toxicity of Water- and Organic-Soluble Wood Tar Fractions from Biomass Burning in Lung Epithelial Cells	11
Impact of Metal–Organic Frameworks on Protein Expression	11
A Weakly Supervised Deep Learning Framework for Whole Slide Classification to Facilitate Digital Pathology in Animal Study	11
Machine Learning Model for Screening Thyroid Stimulating Hormone Receptor Agonists Based on Updated Datasets and Improved Applicability Domain Metrics	11
Ecotoxicity Risk of Low-Dose Methylmercury Exposure to Caenorhabditis elegans: Multigenerational Toxicity and Population Discrepancy	11
Novel Δ⁸-Tetrahydrocannabinol Vaporizers Contain Unlabeled Adulterants, Unintended Byproducts of Chemical Synthesis, and Heavy Metals	11
Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy	11
Association of Urinary N7-(1-hydroxyl-3-buten-1-yl) Guanine (EB-GII) Adducts and Butadiene-Mercapturic Acids with Lung Cancer Development in Cigarette Smokers	11
Multi-DNA Adduct and Abasic Site Quantitation In Vivo by Nano-Liquid Chromatography/High-Resolution Orbitrap Tandem Mass Spectrometry: Methodology for Biomonitoring Colorectal DNA Damage	11
Chlorobenzoquinones Aggravate RSL3-Induced Ferroptosis in ROS-Dependent Manner	11
Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat	11
Behavior Effects of Structurally Diverse Per- and Polyfluoroalkyl Substances in Zebrafish	11
Comparison of Cellular Morphological Descriptors and Molecular Fingerprints for the Prediction of Cytotoxicity- and Proliferation-Related Assays	10
Burn Pit Smoke Condensate-Mediated Toxicity in Human Airway Epithelial Cells	10
Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals	10
Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2	10
Searching for LINCS to Stress: Using Text Mining to Automate Reference Chemical Curation	10
Surfactant Coformulants in Glyphosate-Based Herbicides: Current Gaps, and Paths Forward in Human Biomonitoring	10
Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice	10
Novel 4-Hydroxybenzyl Adducts in Human Hemoglobin: Structures and Mechanisms of Formation	10
PFOS-Induced Perturbations in Trophoblast Functions through the Oip5os1/miR-155/Rnd3 Axis in PE	10
Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-Null, and CYP2A6-Humanized Mice	10
Underlying Mechanisms of Allopurinol in Eliminating Renal Toxicity Induced by Melamine–Uric Acid Complex Formation: A Computational Study	10
Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-l-cysteine Stimulates Changes in Energy Metabolites and Amino Acids in the BeWo Human Placental Trophoblast Model during Syncytiali	10
A Review on the Recent Applications of Deep Learning in Predictive Drug Toxicological Studies	10
Mechanistic Insights into the Role of Iron, Copper, and Carbonaceous Component on the Oxidative Potential of Ultrafine Particulate Matter	10
Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct	10
Using Rotenone to Model Parkinson’s Disease in Mice: A Review of the Role of Pharmacokinetics	10
Effects of Chemicals in Reporter Gene Bioassays with Different Metabolic Activities Compared to Baseline Toxicity	10
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes	10
Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to N-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite	10
New Insights into the Phototoxicity of Anthracene-Based Chromophores: The Chloride Salt Effect	10
Principal Metabolites in Extracts of Different Plants Responsible for Antibacterial Effects	9

Correction to Aberrant Cytokinesis and Cell Fusion Result in Multinucleation in HepG2 Cells Exposed to Silica Nanoparticles	9
Pesticides Inhibit Retinoic Acid Catabolism in PLHC-1 and ZFL Fish Hepatic Cell Lines	9
Enhancing hERG Risk Assessment with Interpretable Classificatory and Regression Models	9
Trelagliptin Mitigates Macrophage Infiltration by Preventing the Breakdown of the Blood–Brain Barrier in the Brain of Middle Cerebral Artery Occlusion Mice	9
Issue Publication Information	9
Variation of Benzo[a]pyrene, NNN, and NNK Levels in 16 Commercial Smokeless Tobacco Products	9
Identification of the Major Product of Guanine Oxidation in DNA by Ozone	9
Women in Toxicology Special Issue	9
Issue Editorial Masthead	9
Silver Nanoparticles Induced Metabolic Perturbations in Pseudomonas aeruginosa: Evaluation Using the UPLC-QTof-MS^E Platform	9
Use of Cause-and-Effect Analysis to Optimize the Reliability of In Vitro Inhalation Toxicity Measurements Using an Air–Liquid Interface	9
Issue Editorial Masthead	9
Interview with Dr. Mingliang Fang, 2023 Young Investigator Award Recipient, American Chemical Society Division of Chemical Toxicology	9
Adenanthin Is an Efficient Inhibitor of Peroxiredoxins from Pathogens, Inhibits Bacterial Growth, and Potentiates Antibiotic Activities	9
Dedication of 35-year Chemical Research in Toxicology Anniversary to Founding Editor Larry Marnett	9
Carbonyl Yields in Cigars under Three Smoking Regimens Using a Linear Smoking Machine	9
Acyl Glucuronide and Coenzyme A Thioester Metabolites of Carboxylic Acid-Containing Drug Molecules: Layering Chemistry with Reactive Metabolism and Toxicology	9
Issue Publication Information	9
Response to ‘Comments on “Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of Commercial Little Cigars”’ Letter to Editor	9
Inhibition of Nicotine Metabolism by Cannabidiol (CBD) and 7-Hydroxycannabidiol (7-OH-CBD)	9
Chemical Research in Toxicology at 35: Recognizing the Impact of Professor Larry Marnett	9
Current Approaches to COVID-19 Drug Discovery and Safety Assessment	9
Dose-Dependent Molecular Responses of Labeo rohita to Triphenyl Phosphate	9
LC–MS/MS Analysis of Reaction Products of Arginine/Methylarginines with Methylglyoxal/Glyoxal	9
Metabolic Activation and Cytotoxicity of Labetalol Hydrochloride Mediated by Sulfotransferases	9
UVB Drives Metabolic Rewiring and Epigenetic Reprograming and Protection by Sulforaphane in Human Skin Keratinocytes	9
Deploying Validated Mass Spectrometry for Frontline Detection and Treatment of Human Poisoning by Long-Acting Anticoagulant Rodenticides	9
Unravelling the Mechanistic Understanding of Metal Nanoparticle-Induced Reactive Oxygen Species Formation: Insights from a Cu Nanoparticle Study	9
Issue Editorial Masthead	9
High Throughput Read-Across for Screening a Large Inventory of Related Structures by Balancing Artificial Intelligence/Machine Learning and Human Knowledge	9
GeoDILI: A Robust and Interpretable Model for Drug-Induced Liver Injury Prediction Using Graph Neural Network-Based Molecular Geometric Representation	8
Latent Variables Capture Pathway-Level Points of Departure in High-Throughput Toxicogenomic Data	8
Issue Editorial Masthead	8
Formation Mechanism and Toxicological Significance of Biogenic Mercury Selenide Nanoparticles in Human Hepatoma HepG2 Cells	8
A Classification Model to Identify Direct-Acting Mutagenic Polycyclic Aromatic Hydrocarbon Transformation Products	8
High Levels of BPA and BPF Exposure during Pregnancy Are Associated with Lower Birth Weight in Shenyang in Northeast China	8
Mouth Level Intake of Nicotine from Three Brands of Little Filtered Cigars with Widely Differing Product Characteristics Among Adult Consumers	8
Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models	8
Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53	8
Using Proteins As Markers for Anabolic Steroid Abuse: A New Perspective in Doping Control?	8
Mass Spectrometric Profiling of Neuropeptides in Response to Copper Toxicity via Isobaric Tagging	8
Issue Publication Information	8
State-Dependent Inhibition of Voltage-Gated Sodium Channels in Neuroblastoma Neuro-2A Cells by Arachidonic Acid from Halichondria okadai	8
Pesticides and the Gut Microbiota: Implications for Parkinson’s Disease	8
Issue Editorial Masthead	8
Effects of a Second Local DNA Damage Event on the Toxicity of the Human Carcinogen 4-Aminobiphenyl: A Molecular Dynamics Study of a Damaged DNA Structure	8
Issue Publication Information	8
Quantum Mechanical Assessment of Nitrosamine Potency	8
Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions	8
Direct Alkylation of Deoxyguanosine by Azaserine Leads to O⁶-Carboxymethyldeoxyguanosine	8
Regulation of BTB (POZ) Structural Domain 6b by MicroRNA-222b in Zebrafish Embryos after Exposure to Di(2-ethylhexyl)phthalate at Low Concentrations	8
ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics	8
Chemical Exposures and Impact on Health	8
Nonylphenol Promoted Epithelial–Mesenchymal Transition in Colorectal Cancer Cells by Upregulating the Expression of Regulator of Cell Cycle	8
Autophagy Promotes α-Amanitin-Induced Apoptosis of Hepa1-6 Liver Cells	8
Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury	8
Introduction to the Special Issue: Mass Spectrometry Advances for Environmental and Human Health	8
Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats	8
Revealing Toxicological Mechanisms of Small Molecules Using Chemical Biology	7
Goniodomic Acid, a Transient Oxirane Intermediate in the Conversion of the Macrolide Algal Toxin Goniodomin A to Seco Acids	7
The Toxicity of Poly(acrylonitrile-styrene–butadiene) Microplastics toward Hyalella azteca Is Associated with Biofragmentation and Oxidative Stress	7
Polyamine Adducts with AP Sites: Interaction with DNA Polymerases and AP Endonucleases	7
Computational Investigation of the Bisphenolic Drug Metabolism by Cytochrome P450: What Factors Favor Intramolecular Phenol Coupling	7
Plasma Protein Binding Evaluations of Per- and Polyfluoroalkyl Substances for Category-Based Toxicokinetic Assessment	7
In Vitro Evaluation of DNA Damage Effect Markers toward Five Nitrogen Mustards Based on Liquid Chromatography–Tandem Mass Spectrometry	7
Practical Aspects of Flavin-Containing Monooxygenase-Mediated Metabolism	7
Characterizing the Transient Emission of Particles and Gases from a Single Puff of Electronic Cigarette Smoke	7
Repurposing the Antihypertensive Agent Hydralazine As an Inhibitor of the Base Excision Repair Enzyme APE1	7
In Vitro, In Vivo, and In Silico Analysis of Pyraclostrobin and Cyprodinil and Their Mixture Reveal New Targets and Signaling Mechanisms	7
Mutagenic and Cancer Risk Estimation of Particulate Bound Polycyclic Aromatic Hydrocarbons from the Emission of Different Biomass Fuels	7
Characterization and Quantification of Acrolein-Induced Modifications in Hemoglobin by Mass Spectrometry─Effect of Cigarette Smoking	7
Ambient Fine Particulate Matter and Cancer: Current Evidence and Future Perspectives	7
Products Generated by Amine-Catalyzed Strand Cleavage at Apurinic/Apyrimidinic Sites in DNA: New Insights from a Biomimetic Nucleoside Model System	7
Phototoxic Effects on Skin Biomolecules Induced by a Domestic Nail Polish Dryer Device	7
Design, Synthesis, and Biological Evaluation of New Oxadiazole Derivatives as Efficient Antihypertension Drugs	7
Issue Editorial Masthead	7
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K/Akt Activation and Its Impact on γ-H2AX Generation	7
What Makes a Potent Nitrosamine? Statistical Validation of Expert-Derived Structure–Activity Relationships	7
Leveraging Cell Painting Images to Expand the Applicability Domain and Actively Improve Deep Learning Quantitative Structure–Activity Relationship Models	7