OOIR: Observatory of International Research

Papers

(The median citation count of Chemical Research in Toxicology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Elevating Research and Careers in the Development of Safer Drugs through Artificial Intelligence	126
Oxidative Deformylation of the Predominant DNA Lesion 5-Formyl-2′-deoxyuridine	125
Issue Publication Information	101
Issue Publication Information	92
Issue Editorial Masthead	72
Issue Editorial Masthead	69
Recent Advances in DNA Lesion Mapping and Repair Mechanisms	65
Identification of an Epoxide Metabolite of Amitriptyline In Vitro and In Vivo	63
Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction	61
Surfactant Coformulants in Glyphosate-Based Herbicides: Current Gaps, and Paths Forward in Human Biomonitoring	57
Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy	56
Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides	56
Protein Haptenation and Its Role in Allergy	55
Structure–Activity Relationship of Protein-Mediated Molecular Initiating Events of Organ-Specific Toxicities	54
Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs	53
Dissecting the Enantioselective Neurotoxicity of Isocarbophos: Chiral Insight from Cellular, Molecular, and Computational Investigations	52
Predicting Liver-Related In Vitro Endpoints with Machine Learning to Support Early Detection of Drug-Induced Liver Injury	51
Coumarin-Based Noncytotoxicity Fluorescent Dye for Tracking Actin Protein in In-Vivo Imaging	49
LA-ICP-MS and Immunohistochemical Staining with Lanthanide-Labeled Antibodies to Study the Uptake of CeO₂ Nanoparticles by Macrophages in Tissue Sections	46
Characterization of the Childhood Exposome with High-Resolution Mass Spectrometry	43
Systematic Investigation of CYP3A4 Using Side-by-Side Comparisons of Apo, Active Site, and Allosteric-Bound States	41
A Weakly Supervised Deep Learning Framework for Whole Slide Classification to Facilitate Digital Pathology in Animal Study	36
A Review on the Recent Applications of Deep Learning in Predictive Drug Toxicological Studies	35
Mechanistic Insights into Toxicity of Titanium Dioxide Nanoparticles at the Micro- and Macro-levels	35
Response to ‘Comments on “Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of Commercial Little Cigars”’ Letter to Editor	34

Issue Editorial Masthead	34
Issue Editorial Masthead	34
Issue Editorial Masthead	33
2,2′,4,4′-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPARγ Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation	32
Issue Editorial Masthead	32
Mixture Toxicity in Human Health: Integrating One Health, Exposomics, and Modern Risk Assessment Strategies	31
Federated Learning in Computational Toxicology: An Industrial Perspective on the Effiris Hackathon	31
ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics	31
LC–MS/MS Analysis of Reaction Products of Arginine/Methylarginines with Methylglyoxal/Glyoxal	29
Structural Elucidation of Agrochemical Metabolic Transformation Products Based on Infrared Ion Spectroscopy to Improve In Silico Toxicity Assessment	29
Issue Publication Information	29
Predictive Modeling of DNA Damage Outcomes: Classification of Mutational Determinants Using Augmented Machine Learning Techniques	28
Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury	28
Modeling the Toxicokinetics of Suspensions of Soluble Metallic Nanomaterials	27
Conditional Binding of Arsenic Trioxide (ATO) to Cysteine-Rich Zinc Finger Motifs within RBCC Domain of PML Protein	27
HDAC6-Mediated NLRP3 Inflammasome Activation Is Involved in Nickel Nanoparticle-Induced Pulmonary Inflammation and Fibrosis	27
Prediction of Cytochrome P450 Substrates Using the Explainable Multitask Deep Learning Models	27
Quantum-Mechanical Approach to Predicting the Carcinogenic Potency of N -Nitroso Impurities in Pharmaceuticals	27
Quantum Mechanical Assessment of Nitrosamine Potency	27
Assessing the Toxicity of Terpene- and Amino Acid-Based Natural Deep Eutectic Solvents	26
The Toxicity of Poly(acrylonitrile-styrene–butadiene) Microplastics toward Hyalella azteca Is Associated with Biofragmentation and Oxidative Stress	26
Endogenous DNA Damage and Its Role in Human Disease	26
Leveraging Cell Painting Images to Expand the Applicability Domain and Actively Improve Deep Learning Quantitative Structure–Activity Relationship Models	26
Computational Prediction of Metabolic α-Carbon Hydroxylation Potential of N -Nitrosamines: Overcoming Data Limitations for Carcinogenicity Assessment	25
Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash	25
Photosensitized Oxidation of Free and Peptide Tryptophan to N-Formylkynurenine	25
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N′-Nitrosonornicotine (NNN) in the Rat	24
Issue Editorial Masthead	24
Advancing Drug Safety in Drug Development: Bridging Computational Predictions for Enhanced Toxicity Prediction	24
Issue Publication Information	23
Issue Publication Information	23
Capturing Differential Quality of Experimental Evidence in a Predictive Quantum-Mechanical Model for Respiratory Sensitization	23
Melatonin Vapes Contain Potential Contaminants and Alter the Human Bronchial Epithelial Transcriptome	22
Zebrafish Larvae as a Predictive Model for the Risk of Chemical-Induced Cholestasis: Phenotypic Evaluation and Nomogram Formation	22
CYP3A4-Mediated Metabolic Activation and Cytotoxicity of Chlortoluron	21
Acrylamide-Aggravated Liver Injury by Activating Endoplasmic Reticulum Stress in Female Mice with Diabetes	21
Circular RNAs: A Potential Regulator in Environmental Chemical Carcinogenesis	21
Nontargeted Analysis in Tobacco Research: Challenges and Opportunities	21
Detection of Trace Skin Sensitizers Using Novel Nucleophiles with Quaternary Ammonium by Liquid Chromatography–Mass Spectrometry	21
Free Radicals in Little Cigar Mainstream Smoke and the Potential Influence of Flavoring Chemicals on Free Radical Production	20
Chemoproteomic Approach for Identifying Nuclear Arsenite-Binding Proteins	20
Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[def,p]chrysene in Human Oral Cells	20
Navigating Transcriptomic Connectivity Mapping Workflows to Link Chemicals with Bioactivities	20
Integrative Data Mining Approach: Case Study with Adverse Outcome Pathway Network Leading to Pulmonary Fibrosis	20
Correction to “1,4-Benzoquinone (PBQ) Induced Toxicity in Lung Epithelial Cells Is Mediated by the Disruption of the Microtubule Network and Activation of Caspase-3”	19
Neuroprotection Against a Panel of Toxicants via a Novel Analog of the Natural Product Fraxinellone	19
Photo-oxidation and Photoreduction of Catechols by Chlorophyll Metabolites and Methylene Blue	19
Deep Learning Models Compared to Experimental Variability for the Prediction of CYP3A4 Time-Dependent Inhibition	19
Toward In Silico NAMs Analysis of Thyroid Disruption Leading to Developmental Neurotoxicity─A Collection of AOP-Anchored Computational Models	19
Heterogeneous Oxidation Products of Fine Particulate Isoprene Epoxydiol-Derived Methyltetrol Sulfates Increase Oxidative Stress and Inflammatory Gene Responses in Human Lung Cells	19

Simultaneous Quantification of Biomarkers for Bis-(2-chloroethyl) Sulfide and 1,2-Bis(2-chloroethylthio) Ethane Exposure in Human Urine at Trace Exposure Levels by Gas Chromatography Tandem Mass Spect	19
Dopamine Release Impairments Accompany Locomotor and Cognitive Deficiencies in Rotenone-Treated Parkinson’s Disease Model Zebrafish	19
Cytocompatibility of Ti₃C₂T_x MXene with Red Blood Cells and Human Umbilical Vein Endothelial Cells and the Underlying Mechanisms	19
The Genotoxicity of Stress	18
A Photoinducible DNA Cross-Linking Agent with Potent Cytotoxicity and Selectivity Toward Triple-Negative Breast Cancer Cell Line	18
Call for Papers for a Special Issue on Mass Spectrometry Advances for Environmental and Human Health	18
Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA Adductomics	18
Novel In Vitro Intestinal Microbiome Model to Study Lipidomic and Metabolomic Adaptations Due to Exposure to Glyphosate, Perfluorooctanoic Acid, and Docusate Sodium	18
Issue Editorial Masthead	18
Correction to “Use of Structural Alerts for Reactive Metabolites in the Application SpotRM”	18
Issue Publication Information	18
Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing	18
Binding of Per- and Polyfluoroalkyl Substances to β-Lactoglobulin from Bovine Milk	18
Aldehyde-Associated Mutagenesis─Current State of Knowledge	18
Introduction to the Special Issue: AI Meets Toxicology	18
Cell Painting and Chemical Structure Read-Across Can Complement Each Other for Rat Acute Oral Toxicity Prediction in Chemical Early Derisking	18
RNA Oxidative Damage by the Iron-Fenton Reaction is Influenced by Bicarbonate Concentration and Ligand Strength	18
Role of Human Aldo–Keto Reductases in the Nitroreduction of 1-Nitropyrene and 1,8-Dinitropyrene	17
Toxicity, Chemistry, and Public Health Relevance of Emerging Nicotine Analog Vapes, Pods, and Pouches	17
Natural Products in Redox Toxicology	17
Photosensitizing Properties of the Topical Retinoid Drug Adapalene	17
New Aminobiphenylcysteine Derivatives in Globin and Urine of Rats Dosed with 4-Aminobiphenyl, a Tobacco Smoke Carcinogen	17
Phthalate Exposure: Prevalence, Health Effects, Regulatory Frameworks, and Remediation	17
Spatiotemporal Visualization of Paraquat Distribution, Toxicokinetics, and Its Detoxification in Zebrafish Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging	16
Issue Editorial Masthead	16
Correction to “Structure-Based Reactivity Profiles of Reactive Metabolites with Glutathione”	16
Issue Publication Information	16
Issue Publication Information	16
Issue Editorial Masthead	16
Activation of V-Domain Immunoglobulin Suppressor of T-Cell Activation by Baloxavir Marboxil Ameliorates Systemic Lupus Erythematosus through Inhibiting Lysophosphatidylcholine/CD40 Ligand	15
Computer-Aided Discovery and Redesign for Respiratory Sensitization: A Tiered Mechanistic Model to Deliver Robust Performance Across a Diverse Chemical Space	15
Recent Contributions of Mass Spectrometry-Based “Omics” in the Studies of Breast Cancer	15
Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis	15
Nuclear DNA and Mitochondrial Damage of the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Human Neuroblastoma Cells	15
Women in Toxicology Special Issue	15
Hazard Profiling of Commercially Relevant Quantum Dot Components Revealed Synergistic Interactions between Heavy Metals and Polymers	15
N-Doped Graphene for Biomedical Applications: A Comparative Biocompatibility Assessment of Green and Chemical Exfoliation	14
Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi	14
Idiosyncratic Drug Reactions: A 35-Year Chemical Research in Toxicology Perspective	14
Cannabidiol Toxicity Driven by Hydroxyquinone Formation	14
Nicotine Dosimetry in Evaluating Electronic Cigarettes Compared to Cigarette Smoking: Implications for Tobacco Regulatory Science	14
One-Week Kava Dietary Supplementation Increases Both Urinary N- and O-Glucuronides of NNAL, a Lung Carcinogen Major Metabolite, among Smokers	14
Cadmium Exposure and Cardiovascular Diseases	14
Dissolution Rate of Nanomaterials Determined by Ions and Particle Size under Lysosomal Conditions: Contributions to Standardization of Simulant Fluids and Analytical Methods	14
Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes	14
Mitochondrial DNA Damage Induced by Aristolochic Acid I: Recognizing the Heart as a Target Organ	14
Issue Editorial Masthead	14
Toxicological Evaluation of Ionic Liquids: QSAR Approach for Acetylcholinesterase Enzyme Inhibition	14
Facile Biological Oxidation of Dopamine to 6-Hydroxydopamine p-Quinone in a Sequential Two-Step Process: Implications for Parkinson’s Disease	14
Phthalate Exposure and Coronary Heart Disease: Possible Implications of Oxidative Stress and Altered miRNA Expression	13
QSAR-ME Profiler 2025: A New Software for QSA(P)R Predictions Supported by Structural Analysis	13
Mechanisms Mediating the Combined Toxicity of Paraquat and Maneb in SH-SY5Y Neuroblastoma Cells	13
Mechanism-Based Inactivation of CYP2C19 by Anwuligan Resulting in Changes in Pharmacokinetic Properties of Amitriptyline	13
CYP2A6 Activity and Deuterated 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Metabolism in Cigarette Smokers	13
Chemoproteomic Approach for the Quantitative Identification of Arsenic-Binding Proteins	13
Production of Peroxymonocarbonate by Steady-State Micromolar H₂O₂ and Activated Macrophages in the Presence of CO₂/HCO₃^– Evidenced by Boronate Pr	13
Tox24 Challenge	13
Human Keratinocyte Responses to Woodsmoke Chemicals	13
High-Field Asymmetric Waveform Ion Mobility Spectrometry Analysis of Carcinogenic Aromatic Amines in Tobacco Smoke with an Orbitrap Tribrid Mass Spectrometer	13
Quantification of Intracellular DNA–Protein Cross-Links with N7-Methyl-2′-Deoxyguanosine and Their Contribution to Cytotoxicity	13
Modelling In vitro Mutagenicity Using Multi-Task Deep Learning and REACH Data	13
Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis	13
Interview with Professor Cynthia J. Burrows, 2022 Founders Award Winner, American Chemical Society Division of Chemical Toxicology	13
8-Oxo-2′-deoxyguanosine Replication in Mutational Hot Spot Sequences of the p53 Gene in Human Cells Is Less Mutagenic than That of the Corresponding Formamidopyrimidine	13
Liver and Intestinal Fatty Acid Binding Proteins Are Not Critical for Perfluorooctanesulfonate (PFOS) Tissue Distribution and Elimination in Mice	13
Honoring Larry Marnett, Founding Editor of Chemical Research in Toxicology	13
Quantitation of Ten Urinary Nicotine Metabolites, Including 4-Hydroxy-4-(3-pyridyl) Butanoic Acid, a Product of Nicotine 2′-Oxidation, and CYP2A6 Activity in Japanese Americans, Native Hawaiians, and	13
Chlorogenic Acid Alleviates Early-Life GenX Exposure-Induced Neurotoxicity via Decreasing Lipopolysaccharide-Induced Pyroptosis by the Systemic Translocation and Suppressing the PI3K/AKT/NF-κB Pathway	13
Human CYP2C19 Substrate and Inhibitor Characterization of Organophosphate Pesticides	12
A New Explanation for the Mystery of Rasputin’s Survival of Cyanide Poisoning: Eating Raw Garlic	12
Prediction of Internal Exposures after Virtual Oral Doses of Disparate Chemicals in Rats and Humans Using Simplified Physiologically Based Pharmacokinetic Models with In Silico-Generated Input	12
Histotoxicity of AIEgen Based on Triphenylamine for the Simultaneous and Discriminatory Sensing of Hg²⁺ and Ag⁺ Directly in Aqueous Media for Environmental Applications	12
Antioxidant Activity and Skin Sensitization of Eugenol and Isoeugenol: Two Sides of the Same Coin?	12
Nucleophilic Addition of Thiols to Methacrylates for Biomedical Applications Revisited	12
Special Issue on Tobacco: Chemistry, Mechanisms, Biomarkers and Disease Prevention	12
Correction to “Oxymatrine Inhibits Liver Cancer Progression by Regulating SIRT1/YY1/GPX4 Axis-Mediated Ferroptosis”	12
Inhibitory Effects of Alkaloids on OATP1B1 In Vitro and In Vivo: Prediction for Food/Herb–Drug Interactions and Hepatoprotective Effects Based on Structure–Activity Relationships	12
Chlorobenzoquinones Aggravate RSL3-Induced Ferroptosis in ROS-Dependent Manner	12
Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice	11
Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study	11

Impact of Dietary Practices on DNA Adduct Formation by Aristolochic Acid I in Mice: Drinking Alkaline Water as a Risk Mitigation Strategy	11
Increased Levels of the Acrolein Metabolite 3-Hydroxypropyl Mercapturic Acid in the Urine of e-Cigarette Users	11
Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating CD36 Upregulation	11
Binding of N -(1,3-Dimethylbutyl)- N’ -phenyl- p -phenylene	11
New Insights into the Phototoxicity of Anthracene-Based Chromophores: The Chloride Salt Effect	11
The Challenge and Opportunity to Rationally Design Safer Commercial Chemicals	11
Carbonyls and Aerosol Mass Generation from Vaping Nicotine Salt Solutions Using Fourth- and Third-Generation E-Cigarette Devices: Effects of Coil Resistance, Coil Age, and Coil Metal Material	11
Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct	11
Multiplatform Metabolomics to Understand the Imidacloprid-Induced Toxicity in Drosophila	11
Leveraging Consensus Docking Approaches for Human Mitochondrial Complexes I and III	11
Issue Editorial Masthead	11
Effects of E-Cigarette Flavor Enhancing Capsules on Inhalable Aerosols	11
Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-Null, and CYP2A6-Humanized Mice	10
Call for Papers: Special Issue on Nucleic Acid Modifications	10
Inhibition of Nicotine Metabolism by Cannabidiol (CBD) and 7-Hydroxycannabidiol (7-OH-CBD)	10
Searching for LINCS to Stress: Using Text Mining to Automate Reference Chemical Curation	10
Pesticides Inhibit Retinoic Acid Catabolism in PLHC-1 and ZFL Fish Hepatic Cell Lines	10
New Docking, Molecular Dynamics, and QSAR Models to Predict Disruption of Human and Rat Transthyretin Function by Per- and Polyfluoroalkyl Substances (PFAS)	10
Identification of the Major Product of Guanine Oxidation in DNA by Ozone	10
8-OxodGuo and Fapy•dG Mutagenicity in Escherichia coli Increases Significantly when They Are Part of a Tandem Lesion with 5-Formyl-2′-deoxyuridine	10
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes	10
Issue Publication Information	10
The Human Glyoxalase Gene Family in Health and Disease	10
Comparative Study of Molecular Descriptors and AI-Based Embeddings for Toxicity Prediction	10
Chemical Exposures and Impact on Health	10
Ambient Fine Particulate Matter and Cancer: Current Evidence and Future Perspectives	10
Issue Publication Information	10
Polyamine Adducts with AP Sites: Interaction with DNA Polymerases and AP Endonucleases	10
Isotope Labeling Mass Spectrometry to Quantify Endogenous and Exogenous DNA Adducts and Metabolites of 1,3-Butadiene In Vivo	9
Effect of Cigarette Type and Smoking Behavior on Urinary Metabolite Levels of Tobacco-Associated Toxicants	9
Metabolic Characterization of Sarin, Cyclosarin, and Novichoks (A-230, A-232) in Human Liver Microsomes	9
Endocrine Disruptor 2,7-Dibromocarbazole Disrupts Energy Metabolism and Alters Locomotor Behavior in Juvenile Zebrafish	9
Is Baikiain in Tara Flour a Causative Agent for the Adverse Events Associated with the Recalled Frozen French Lentil & Leek Crumbles Food Product? - A Working Hypothesis	9
Combining Molecular Docking and Pharmacophore Models Predicts Ligand Binding of Endocrine-Disrupting Chemicals to Nuclear Receptors	9
Evidence for the Metabolic Activation of Deferasirox In Vitro and In Vivo	9
Issue Publication Information	9
Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World	9
Introducing the Inaugural Early Career Board for Chemical Research in Toxicology	9
Evaluation of Six Aromatic Amines in the Mainstream Smoke of Commercial Cigars	9
Covalently Active Metabolites of Bisphenol A Analogs by Mass Spectrometry Diagnostic Ions: Possible Mechanisms of Their Toxicity	9
Review of the Protective Effects of Selenium against T-2 Toxin-Induced Toxicity	9
Correction to “Identification of Butyrylcholinesterase-Derived Small Molecule Peptides Indicative of Novichok Nerve Agent Exposures”	9
Mixtures-Inclusive In Silico Models of Ocular Toxicity Based on United States and International Hazard Categories	9
Perfluorohexyloctane: More than Meets the Eye?	9
Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking	9
MlrA, an Essential Enzyme for Microcystins and Nodularin on First Step Biodegradation in Microcystin-Degrading Bacteria	9
Nuclear SUMOylation and Proteotoxic Stress Responses to Metals with Different Ligand Preferences	8
Issue Publication Information	8
Ratiometric Fluorescent Probe for the Detection of Nanomolar Phosgene in Solution and Gaseous Phase: Advancing Crime Detection Applications	8
Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1,8-Dinitropyrene and Its Metabolite 1-Amino-8-nitropyrene via Nitroreduction in Human	8
Urinary Profile of Alkylated DNA Adducts and DNA Oxidative Damage in Sulfur Mustard-Exposed Rats Revealed by Mass Spectrometry Quantification	8
Interview with Dr. Wei Yang, 2022 Keynote Speaker, American Chemical Society Division of Chemical Toxicology	8
A Membrane Biophysics Perspective on the Mechanism of Alcohol Toxicity	8
Conformation and Pairing Properties of anO⁶-Methyl-2′-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA	8
Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1	8
Quantification of Flavors, Volatile Organic Compounds, Tobacco Markers, and Tobacco-Specific Nitrosamines in Heated Tobacco Products and Their Mainstream Aerosol	8
Carbonyl Emissions and Heating Temperatures across 75 Nominally Identical Electronic Nicotine Delivery System Products: Do Manufacturing Variations Drive Pulmonary Toxicant Exposure?	8
Issue Publication Information	8
Improving Volatile Organic Compound Exposure Assessment Using Biomonitoring by Relating Exposure Biomarker Levels in Blood and Urine	8
Halogen Atoms in Bisphenol A Derivatives Enhance the Inhibitory Potency against Human and Rat Placental 3β-Hydroxysteroid Dehydrogenases	8
Issue Editorial Masthead	8
Conformation-Dependent Lesion Bypass and Mutagenicity of Bulky 2-Acetylaminofluorene-Guanine DNA Adduct in Epigenetically Relevant Sequence Contexts	8
Early ADME and Preliminary Toxicity Studies of I-152, an N -Acetyl- l -Cysteine/ <	8
Nature-Derived Epoxy Resin Monomers with Reduced Sensitizing Capacity─Isosorbide-Based Bis-Epoxides	8
Free Radicals in Cannabis Smoke	8
Migration of Soluble Polymers in Human Saliva during Swabbing Characterized by Direct Electrospray Ionization Mass Spectrometry	8
Issue Publication Information	8
Identification of Metoprolol Tartrate-Derived Reactive Metabolites Possibly Correlated with Its Cytotoxicity	8
A Novel Inhibitor of Poly(ADP-Ribose) Polymerase-1 Inhibits Proliferation of a BRCA-Deficient Breast Cancer Cell Line *via* the DNA Damage–Activated cGAS–STING	8
Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements	8
Issue Editorial Masthead	8
A Virtual Issue of Chemical Research in Toxicology in Celebration of the International Day of Women and Girls in Science	8
Data Exploration for Target Predictions Using Proprietary and Publicly Available Data Sets	8
Untargeted DNA Adductomics Identifies Aristolochic Acid III as a Potent DNA-Damaging Agent among 11 Substituted Aromatic Genotoxicants in the Rat Urinary System	7
In Vitro Metabolism and p53 Activation of Genotoxic Chemicals: Abiotic CYP Enzyme vs Liver Microsomes	7
Issue Editorial Masthead	7
Issue Publication Information	7
Effect of Butyrate on Food-Grade Titanium Dioxide Toxicity in Different Intestinal In Vitro Models	7
An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis	7
A Quick Method for the Determination of the Fraction of Freebase Nicotine in Electronic Cigarettes	7
High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter	7
Toxic Effects of Cobalt on Erythroid Progenitor Cells	7
A Computational Framework to Evaluate Interactions of BPA and Its Analogs with Human Liver X Receptor-Beta for Health Risk Assessment	7
Developing Role for Artificial Intelligence in Drug Discovery in Drug Design, Development, and Safety Assessment	7
Issue Publication Information	7
Complex Reactivity of Bisphenol A Diglycidyl Ether (BADGE) with DNA	7
Ultrasonic Extraction-Based Analysis of Persistent Organic Pollutants in Blubber from False Killer Whales	7
Imidazole-Based ALK5 Inhibitor Attenuates TGF-β/Smad-Mediated Hepatic Stellate Cell Activation and Hepatic Fibrogenesis	7
MetSim: Integrated Programmatic Access and Pathway Management for Xenobiotic Metabolism Simulators	7
Evaluating the Toxicity of Electronic Cigarette Aerosols for Firsthand and Secondhand Exposure Under Different Device Operating Conditions	7
Chronic Arsenic Exposure Perturbs Gut Microbiota and Bile Acid Homeostasis in Mice	7
Issue Publication Information	7
Advancements in Nanomedicine for Allergic Diseases: Diagnosis, Toxicity, and Therapeutic Strategies	7
Comparative Studies on Bulky DNA Damage Binding by Nucleotide Excision Repair Proteins Using Surface Plasmon Resonance, Differential Scanning Fluorometry, and DNase I Footprinting	7
Relationship of Urinary Mercapturic Acids of Selected Tobacco Smoke Constituents to Chronic Obstructive Pulmonary Disease in Cigarette Smokers of the Singapore Chinese Health Study	7