OOIR: Observatory of International Research

Papers

(The median citation count of Chemical Research in Toxicology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Elevating Research and Careers in the Development of Safer Drugs through Artificial Intelligence	147
Oxidative Deformylation of the Predominant DNA Lesion 5-Formyl-2′-deoxyuridine	143
Issue Publication Information	122
Issue Publication Information	109
Issue Editorial Masthead	83
Issue Editorial Masthead	80
Recent Advances in DNA Lesion Mapping and Repair Mechanisms	68
Identification of an Epoxide Metabolite of Amitriptyline In Vitro and In Vivo	66
Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction	64
Surfactant Coformulants in Glyphosate-Based Herbicides: Current Gaps, and Paths Forward in Human Biomonitoring	61
Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides	58
Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs	57
Characterization of the Childhood Exposome with High-Resolution Mass Spectrometry	56
Dissecting the Enantioselective Neurotoxicity of Isocarbophos: Chiral Insight from Cellular, Molecular, and Computational Investigations	56
Coumarin-Based Noncytotoxicity Fluorescent Dye for Tracking Actin Protein in In-Vivo Imaging	54
Systematic Investigation of CYP3A4 Using Side-by-Side Comparisons of Apo, Active Site, and Allosteric-Bound States	51
Predicting Liver-Related In Vitro Endpoints with Machine Learning to Support Early Detection of Drug-Induced Liver Injury	48
Structure–Activity Relationship of Protein-Mediated Molecular Initiating Events of Organ-Specific Toxicities	44
Mechanistic Insights into Toxicity of Titanium Dioxide Nanoparticles at the Micro- and Macro-levels	44
Protein Haptenation and Its Role in Allergy	42
A Weakly Supervised Deep Learning Framework for Whole Slide Classification to Facilitate Digital Pathology in Animal Study	40
Issue Editorial Masthead	39
A Review on the Recent Applications of Deep Learning in Predictive Drug Toxicological Studies	39
Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy	39
Issue Editorial Masthead	37

Issue Editorial Masthead	36
Issue Editorial Masthead	35
ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics	34
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N′-Nitrosonornicotine (NNN) in the Rat	33
Photosensitized Oxidation of Free and Peptide Tryptophan to N-Formylkynurenine	32
Predictive Modeling of DNA Damage Outcomes: Classification of Mutational Determinants Using Augmented Machine Learning Techniques	31
Leveraging Cell Painting Images to Expand the Applicability Domain and Actively Improve Deep Learning Quantitative Structure–Activity Relationship Models	31
Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury	31
Assessing the Toxicity of Terpene- and Amino Acid-Based Natural Deep Eutectic Solvents	31
Issue Publication Information	31
The Toxicity of Poly(acrylonitrile-styrene–butadiene) Microplastics toward Hyalella azteca Is Associated with Biofragmentation and Oxidative Stress	30
Modeling the Toxicokinetics of Suspensions of Soluble Metallic Nanomaterials	30
Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash	29
Computational Prediction of Metabolic α-Carbon Hydroxylation Potential of N -Nitrosamines: Overcoming Data Limitations for Carcinogenicity Assessment	29
Quantum Mechanical Assessment of Nitrosamine Potency	29
Few-Shot Prediction of Toxicity of Ionic Liquids Supported by Attentive Model-Agnostic Meta-Learning	28
LC–MS/MS Analysis of Reaction Products of Arginine/Methylarginines with Methylglyoxal/Glyoxal	28
Endogenous DNA Damage and Its Role in Human Disease	28
Quantum-Mechanical Approach to Predicting the Carcinogenic Potency of N -Nitroso Impurities in Pharmaceuticals	28
Federated Learning in Computational Toxicology: An Industrial Perspective on the Effiris Hackathon	27
HDAC6-Mediated NLRP3 Inflammasome Activation Is Involved in Nickel Nanoparticle-Induced Pulmonary Inflammation and Fibrosis	27
Structural Elucidation of Agrochemical Metabolic Transformation Products Based on Infrared Ion Spectroscopy to Improve In Silico Toxicity Assessment	26
Conditional Binding of Arsenic Trioxide (ATO) to Cysteine-Rich Zinc Finger Motifs within RBCC Domain of PML Protein	26
Prediction of Cytochrome P450 Substrates Using the Explainable Multitask Deep Learning Models	26
Mixture Toxicity in Human Health: Integrating One Health, Exposomics, and Modern Risk Assessment Strategies	25
Issue Editorial Masthead	25
Advancing Drug Safety in Drug Development: Bridging Computational Predictions for Enhanced Toxicity Prediction	25
Issue Publication Information	24
Issue Publication Information	24
Heterogeneous Oxidation Products of Fine Particulate Isoprene Epoxydiol-Derived Methyltetrol Sulfates Increase Oxidative Stress and Inflammatory Gene Responses in Human Lung Cells	23
Melatonin Vapes Contain Potential Contaminants and Alter the Human Bronchial Epithelial Transcriptome	23
Capturing Differential Quality of Experimental Evidence in a Predictive Quantum-Mechanical Model for Respiratory Sensitization	23
Zebrafish Larvae as a Predictive Model for the Risk of Chemical-Induced Cholestasis: Phenotypic Evaluation and Nomogram Formation	23
CYP3A4-Mediated Metabolic Activation and Cytotoxicity of Chlortoluron	23
Navigating Transcriptomic Connectivity Mapping Workflows to Link Chemicals with Bioactivities	22
Circular RNAs: A Potential Regulator in Environmental Chemical Carcinogenesis	22
Detection of Trace Skin Sensitizers Using Novel Nucleophiles with Quaternary Ammonium by Liquid Chromatography–Mass Spectrometry	22
Chemoproteomic Approach for Identifying Nuclear Arsenite-Binding Proteins	21
Simultaneous Quantification of Biomarkers for Bis-(2-chloroethyl) Sulfide and 1,2-Bis(2-chloroethylthio) Ethane Exposure in Human Urine at Trace Exposure Levels by Gas Chromatography Tandem Mass Spect	21
Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[def,p]chrysene in Human Oral Cells	21
Acrylamide-Aggravated Liver Injury by Activating Endoplasmic Reticulum Stress in Female Mice with Diabetes	21
Dopamine Release Impairments Accompany Locomotor and Cognitive Deficiencies in Rotenone-Treated Parkinson’s Disease Model Zebrafish	21
Free Radicals in Little Cigar Mainstream Smoke and the Potential Influence of Flavoring Chemicals on Free Radical Production	20
Correction to “1,4-Benzoquinone (PBQ) Induced Toxicity in Lung Epithelial Cells Is Mediated by the Disruption of the Microtubule Network and Activation of Caspase-3”	20
3D Printing Filament Composition, Emissions, and Induced Proinflammatory Responses	20
Toward In Silico NAMs Analysis of Thyroid Disruption Leading to Developmental Neurotoxicity─A Collection of AOP-Anchored Computational Models	20
Nontargeted Analysis in Tobacco Research: Challenges and Opportunities	20
Neuroprotection Against a Panel of Toxicants via a Novel Analog of the Natural Product Fraxinellone	20
Integrative Data Mining Approach: Case Study with Adverse Outcome Pathway Network Leading to Pulmonary Fibrosis	20
Call for Papers for a Special Issue on Mass Spectrometry Advances for Environmental and Human Health	19

The Genotoxicity of Stress	19
Photo-oxidation and Photoreduction of Catechols by Chlorophyll Metabolites and Methylene Blue	19
Deep Learning Models Compared to Experimental Variability for the Prediction of CYP3A4 Time-Dependent Inhibition	19
Cytocompatibility of Ti₃C₂T_x MXene with Red Blood Cells and Human Umbilical Vein Endothelial Cells and the Underlying Mechanisms	19
Aldehyde-Associated Mutagenesis─Current State of Knowledge	19
Novel In Vitro Intestinal Microbiome Model to Study Lipidomic and Metabolomic Adaptations Due to Exposure to Glyphosate, Perfluorooctanoic Acid, and Docusate Sodium	18
Issue Editorial Masthead	18
Correction to “Use of Structural Alerts for Reactive Metabolites in the Application SpotRM”	18
Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA Adductomics	18
A Photoinducible DNA Cross-Linking Agent with Potent Cytotoxicity and Selectivity Toward Triple-Negative Breast Cancer Cell Line	18
Photosensitizing Properties of the Topical Retinoid Drug Adapalene	18
Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing	18
Di-2-ethylhexyl Phthalate Reprograms Epithelial–Mesenchymal Transition and Lenvatinib Responsiveness in Hepatoma Cells via SPAG4-Dependent MAPK/ERK Signaling	17
Cell Painting and Chemical Structure Read-Across Can Complement Each Other for Rat Acute Oral Toxicity Prediction in Chemical Early Derisking	17
DNA Structure-Dependent Enrichment of Oxidative Lesions	17
Role of Human Aldo–Keto Reductases in the Nitroreduction of 1-Nitropyrene and 1,8-Dinitropyrene	17
Binding of Per- and Polyfluoroalkyl Substances to β-Lactoglobulin from Bovine Milk	17
Issue Publication Information	16
Advancing Science in India: Chemistry and Toxicology	16
Screening the Tox21 Compound Library for Chemicals That Stimulate the Adrenergic β1 Receptor	16
Issue Editorial Masthead	16
Phthalate Exposure: Prevalence, Health Effects, Regulatory Frameworks, and Remediation	16
RNA Oxidative Damage by the Iron-Fenton Reaction is Influenced by Bicarbonate Concentration and Ligand Strength	16
Issue Editorial Masthead	16
New Aminobiphenylcysteine Derivatives in Globin and Urine of Rats Dosed with 4-Aminobiphenyl, a Tobacco Smoke Carcinogen	16
Introduction to the Special Issue: AI Meets Toxicology	16
Toxicity, Chemistry, and Public Health Relevance of Emerging Nicotine Analog Vapes, Pods, and Pouches	16
Mechanism-Based Inactivation of CYP2C19 by Anwuligan Resulting in Changes in Pharmacokinetic Properties of Amitriptyline	15
Activation of V-Domain Immunoglobulin Suppressor of T-Cell Activation by Baloxavir Marboxil Ameliorates Systemic Lupus Erythematosus through Inhibiting Lysophosphatidylcholine/CD40 Ligand	15
Issue Publication Information	15
Next-Generation Sequencing Analysis of 8-Oxo-7,8-dihydroguanine in Human Mitochondrial DNA	15
Computer-Aided Discovery and Redesign for Respiratory Sensitization: A Tiered Mechanistic Model to Deliver Robust Performance Across a Diverse Chemical Space	15
Nuclear DNA and Mitochondrial Damage of the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Human Neuroblastoma Cells	15
Correction to “Structure-Based Reactivity Profiles of Reactive Metabolites with Glutathione”	15
Women in Toxicology Special Issue	15
Spatiotemporal Visualization of Paraquat Distribution, Toxicokinetics, and Its Detoxification in Zebrafish Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging	15
Facile Biological Oxidation of Dopamine to 6-Hydroxydopamine p-Quinone in a Sequential Two-Step Process: Implications for Parkinson’s Disease	15
Issue Editorial Masthead	14
Mitochondrial DNA Damage Induced by Aristolochic Acid I: Recognizing the Heart as a Target Organ	14
Mechanisms Mediating the Combined Toxicity of Paraquat and Maneb in SH-SY5Y Neuroblastoma Cells	14
Nicotine Dosimetry in Evaluating Electronic Cigarettes Compared to Cigarette Smoking: Implications for Tobacco Regulatory Science	14
Toxicological Evaluation of Ionic Liquids: QSAR Approach for Acetylcholinesterase Enzyme Inhibition	14
N-Doped Graphene for Biomedical Applications: A Comparative Biocompatibility Assessment of Green and Chemical Exfoliation	14
Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes	14
Sex-Specific Modulation of Drug Metabolizing Enzymes, Transporters, and Pro-Inflammatory Cytokines by Arsenic Trioxide in C57Bl/6 Mice	14
Cadmium Exposure and Cardiovascular Diseases	14
Tox24 Challenge	13
8-Oxo-2′-deoxyguanosine Replication in Mutational Hot Spot Sequences of the p53 Gene in Human Cells Is Less Mutagenic than That of the Corresponding Formamidopyrimidine	13
Hazard Profiling of Commercially Relevant Quantum Dot Components Revealed Synergistic Interactions between Heavy Metals and Polymers	13
Recent Contributions of Mass Spectrometry-Based “Omics” in the Studies of Breast Cancer	13
Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis	13
Issue Editorial Masthead	13
Human Keratinocyte Responses to Woodsmoke Chemicals	13
One-Week Kava Dietary Supplementation Increases Both Urinary N- and O-Glucuronides of NNAL, a Lung Carcinogen Major Metabolite, among Smokers	13
QSAR-ME Profiler 2025: A New Software for QSA(P)R Predictions Supported by Structural Analysis	13
Cannabidiol Toxicity Driven by Hydroxyquinone Formation	13
Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi	13
Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis	12
Prediction of Ligand Binding to Transthyretin Using Machine Learning Algorithms and Low-Dimensional Molecular Descriptors: A Tox24 Challenge Study	12
Chemoproteomic Approach for the Quantitative Identification of Arsenic-Binding Proteins	12
Quantification of Intracellular DNA–Protein Cross-Links with N7-Methyl-2′-Deoxyguanosine and Their Contribution to Cytotoxicity	12
Interview with Professor Cynthia J. Burrows, 2022 Founders Award Winner, American Chemical Society Division of Chemical Toxicology	12
Liver and Intestinal Fatty Acid Binding Proteins Are Not Critical for Perfluorooctanesulfonate (PFOS) Tissue Distribution and Elimination in Mice	12
Issue Publication Information	12
Histotoxicity of AIEgen Based on Triphenylamine for the Simultaneous and Discriminatory Sensing of Hg²⁺ and Ag⁺ Directly in Aqueous Media for Environmental Applications	12
Phthalate Exposure and Coronary Heart Disease: Possible Implications of Oxidative Stress and Altered miRNA Expression	12
Quantitation of Ten Urinary Nicotine Metabolites, Including 4-Hydroxy-4-(3-pyridyl) Butanoic Acid, a Product of Nicotine 2′-Oxidation, and CYP2A6 Activity in Japanese Americans, Native Hawaiians, and	12
Sensitive Quantification of the Ethylene Oxide Hemoglobin Adduct N -(2-Hydroxyethyl)- l -valine from M	12
Production of Peroxymonocarbonate by Steady-State Micromolar H₂O₂ and Activated Macrophages in the Presence of CO₂/HCO₃^– Evidenced by Boronate Pr	12
High-Field Asymmetric Waveform Ion Mobility Spectrometry Analysis of Carcinogenic Aromatic Amines in Tobacco Smoke with an Orbitrap Tribrid Mass Spectrometer	12
CYP2A6 Activity and Deuterated 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Metabolism in Cigarette Smokers	11
Generation of Interstrand DNA Cross-Links under Conditions of Acid Stress	11
Antioxidant Activity and Skin Sensitization of Eugenol and Isoeugenol: Two Sides of the Same Coin?	11
Carbonyls and Aerosol Mass Generation from Vaping Nicotine Salt Solutions Using Fourth- and Third-Generation E-Cigarette Devices: Effects of Coil Resistance, Coil Age, and Coil Metal Material	11
Modelling In vitro Mutagenicity Using Multi-Task Deep Learning and REACH Data	11
Chlorogenic Acid Alleviates Early-Life GenX Exposure-Induced Neurotoxicity via Decreasing Lipopolysaccharide-Induced Pyroptosis by the Systemic Translocation and Suppressing the PI3K/AKT/NF-κB Pathway	11
Special Issue on Tobacco: Chemistry, Mechanisms, Biomarkers and Disease Prevention	11
Human CYP2C19 Substrate and Inhibitor Characterization of Organophosphate Pesticides	11
Context-Aware Multilevel Classification of Semantic Relations in Drug-Adverse Drug Reaction (ADR) Networks–Predicting Drug-Induced Liver Injury (DILI) as a Case Study	11
Correction to “Oxymatrine Inhibits Liver Cancer Progression by Regulating SIRT1/YY1/GPX4 Axis-Mediated Ferroptosis”	11

Nucleophilic Addition of Thiols to Methacrylates for Biomedical Applications Revisited	11
Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct	10
Comparative Study of Molecular Descriptors and AI-Based Embeddings for Toxicity Prediction	10
Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice	10
Uncovering the Hidden Risks: How PLA and PLGA Microplastics Disrupt Gut Microbiota and Metabolic Health	10
Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-Null, and CYP2A6-Humanized Mice	10
New Insights into the Phototoxicity of Anthracene-Based Chromophores: The Chloride Salt Effect	10
Effects of E-Cigarette Flavor Enhancing Capsules on Inhalable Aerosols	10
Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study	10
Chlorobenzoquinones Aggravate RSL3-Induced Ferroptosis in ROS-Dependent Manner	10
Leveraging Consensus Docking Approaches for Human Mitochondrial Complexes I and III	10
Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating CD36 Upregulation	10
AOP Network Box: An Integrative Framework for Bridging Adverse Outcome Pathways and Biological Networks	10
Issue Publication Information	10
The Challenge and Opportunity to Rationally Design Safer Commercial Chemicals	10
Issue Editorial Masthead	10
Multiplatform Metabolomics to Understand the Imidacloprid-Induced Toxicity in Drosophila	10
Prediction of Internal Exposures after Virtual Oral Doses of Disparate Chemicals in Rats and Humans Using Simplified Physiologically Based Pharmacokinetic Models with In Silico-Generated Input	10
Binding of N -(1,3-Dimethylbutyl)- N’ -phenyl- p -phenylene	10
Inhibitory Effects of Alkaloids on OATP1B1 In Vitro and In Vivo: Prediction for Food/Herb–Drug Interactions and Hepatoprotective Effects Based on Structure–Activity Relationships	10
New Docking, Molecular Dynamics, and QSAR Models to Predict Disruption of Human and Rat Transthyretin Function by Per- and Polyfluoroalkyl Substances (PFAS)	10
Impact of Dietary Practices on DNA Adduct Formation by Aristolochic Acid I in Mice: Drinking Alkaline Water as a Risk Mitigation Strategy	10
Isotope Labeling Mass Spectrometry to Quantify Endogenous and Exogenous DNA Adducts and Metabolites of 1,3-Butadiene In Vivo	9
Polyamine Adducts with AP Sites: Interaction with DNA Polymerases and AP Endonucleases	9
Inhibition of Nicotine Metabolism by Cannabidiol (CBD) and 7-Hydroxycannabidiol (7-OH-CBD)	9
Covalently Active Metabolites of Bisphenol A Analogs by Mass Spectrometry Diagnostic Ions: Possible Mechanisms of Their Toxicity	9
Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking	9
Issue Publication Information	9
Correction to “Identification of Butyrylcholinesterase-Derived Small Molecule Peptides Indicative of Novichok Nerve Agent Exposures”	9
Issue Publication Information	9
Multiparametric and Pathomimetic In Vitro Platform Mimicking Human Hepatic Steatosis, Lipotoxicity, and Associated Metabolic Stress	9
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes	9
The Human Glyoxalase Gene Family in Health and Disease	9
Ambient Fine Particulate Matter and Cancer: Current Evidence and Future Perspectives	9
Combining Molecular Docking and Pharmacophore Models Predicts Ligand Binding of Endocrine-Disrupting Chemicals to Nuclear Receptors	9
Endocrine Disruptor 2,7-Dibromocarbazole Disrupts Energy Metabolism and Alters Locomotor Behavior in Juvenile Zebrafish	9
8-OxodGuo and Fapy•dG Mutagenicity in Escherichia coli Increases Significantly when They Are Part of a Tandem Lesion with 5-Formyl-2′-deoxyuridine	9
Call for Papers: Special Issue on Nucleic Acid Modifications	9
Searching for LINCS to Stress: Using Text Mining to Automate Reference Chemical Curation	9
MlrA, an Essential Enzyme for Microcystins and Nodularin on First Step Biodegradation in Microcystin-Degrading Bacteria	9
Is Baikiain in Tara Flour a Causative Agent for the Adverse Events Associated with the Recalled Frozen French Lentil & Leek Crumbles Food Product? - A Working Hypothesis	9
Review of the Protective Effects of Selenium against T-2 Toxin-Induced Toxicity	9
Evaluation of Six Aromatic Amines in the Mainstream Smoke of Commercial Cigars	9
Evidence for the Metabolic Activation of Deferasirox In Vitro and In Vivo	9
Effect of Cigarette Type and Smoking Behavior on Urinary Metabolite Levels of Tobacco-Associated Toxicants	9
Chemical Exposures and Impact on Health	9
Metabolic Characterization of Sarin, Cyclosarin, and Novichoks (A-230, A-232) in Human Liver Microsomes	8
Introducing the Inaugural Early Career Board for Chemical Research in Toxicology	8
Early ADME and Preliminary Toxicity Studies of I-152, an N -Acetyl- l -Cysteine/ <	8
A Computational Framework to Evaluate Interactions of BPA and Its Analogs with Human Liver X Receptor-Beta for Health Risk Assessment	8
Issue Editorial Masthead	8
Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1	8
Issue Publication Information	8
Free Radicals in Cannabis Smoke	8
Ratiometric Fluorescent Probe for the Detection of Nanomolar Phosgene in Solution and Gaseous Phase: Advancing Crime Detection Applications	8
Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1,8-Dinitropyrene and Its Metabolite 1-Amino-8-nitropyrene via Nitroreduction in Human	8
Data Exploration for Target Predictions Using Proprietary and Publicly Available Data Sets	8
Issue Publication Information	8
MetSim: Integrated Programmatic Access and Pathway Management for Xenobiotic Metabolism Simulators	8
Conformation and Pairing Properties of anO⁶-Methyl-2′-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA	8
A Membrane Biophysics Perspective on the Mechanism of Alcohol Toxicity	8
Quantification of Flavors, Volatile Organic Compounds, Tobacco Markers, and Tobacco-Specific Nitrosamines in Heated Tobacco Products and Their Mainstream Aerosol	8
Issue Publication Information	8
Migration of Soluble Polymers in Human Saliva during Swabbing Characterized by Direct Electrospray Ionization Mass Spectrometry	8
Perfluorohexyloctane: More than Meets the Eye?	8
Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World	8
Nature-Derived Epoxy Resin Monomers with Reduced Sensitizing Capacity─Isosorbide-Based Bis-Epoxides	8
Dried Matrix Spots: An Underutilized and Unexplored Technology in India	8
Nuclear SUMOylation and Proteotoxic Stress Responses to Metals with Different Ligand Preferences	8
Carbonyl Emissions and Heating Temperatures across 75 Nominally Identical Electronic Nicotine Delivery System Products: Do Manufacturing Variations Drive Pulmonary Toxicant Exposure?	8
Improving Volatile Organic Compound Exposure Assessment Using Biomonitoring by Relating Exposure Biomarker Levels in Blood and Urine	8
Untargeted DNA Adductomics Identifies Aristolochic Acid III as a Potent DNA-Damaging Agent among 11 Substituted Aromatic Genotoxicants in the Rat Urinary System	7
Identification of Specific Hemoglobin Adduct Patterns in Users of Different Tobacco/nicotine Products by Nontargeted GC–MS/MS Analysis	7
A Novel Inhibitor of Poly(ADP-Ribose) Polymerase-1 Inhibits Proliferation of a BRCA-Deficient Breast Cancer Cell Line *via* the DNA Damage–Activated cGAS–STING	7
Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements	7
Conformation-Dependent Lesion Bypass and Mutagenicity of Bulky 2-Acetylaminofluorene-Guanine DNA Adduct in Epigenetically Relevant Sequence Contexts	7
In Vitro Metabolism and p53 Activation of Genotoxic Chemicals: Abiotic CYP Enzyme vs Liver Microsomes	7
Issue Publication Information	7
Developing Role for Artificial Intelligence in Drug Discovery in Drug Design, Development, and Safety Assessment	7
Toxic Effects of Cobalt on Erythroid Progenitor Cells	7
The Potential Contribution of Hexavalent Chromium to the Carcinogenicity of Chrysotile Asbestos	7
Interview with Dr. Wei Yang, 2022 Keynote Speaker, American Chemical Society Division of Chemical Toxicology	7
Halogen Atoms in Bisphenol A Derivatives Enhance the Inhibitory Potency against Human and Rat Placental 3β-Hydroxysteroid Dehydrogenases	7
Urinary Profile of Alkylated DNA Adducts and DNA Oxidative Damage in Sulfur Mustard-Exposed Rats Revealed by Mass Spectrometry Quantification	7
Advancements in Nanomedicine for Allergic Diseases: Diagnosis, Toxicity, and Therapeutic Strategies	7
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells	7
A Quick Method for the Determination of the Fraction of Freebase Nicotine in Electronic Cigarettes	7
Evaluating the Toxicity of Electronic Cigarette Aerosols for Firsthand and Secondhand Exposure Under Different Device Operating Conditions	7
A Virtual Issue of Chemical Research in Toxicology in Celebration of the International Day of Women and Girls in Science	7
Issue Editorial Masthead	7
Quantum Chemical Evaluation and QSAR Modeling of N-Nitrosamine Carcinogenicity	7
Cytotoxic Homo- and Hetero-Dimers of o-toluidine, o-anisidine, and Aniline Formed by In Vitro Metabolism	7
Predicting Aquatic Species Sensitivity Distributions Using Machine Learning in a Regulatory Setting	7
Complex Reactivity of Bisphenol A Diglycidyl Ether (BADGE) with DNA	7
Analytical Identification of Novel Furan Metabolites in Human Hepatocytes and Urine: Implications for Liver and Respiratory Disease Research	7