OOIR: Observatory of International Research

Papers

(The median citation count of Chemical Research in Toxicology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Elevating Research and Careers in the Development of Safer Drugs through Artificial Intelligence	99
Oxidative Deformylation of the Predominant DNA Lesion 5-Formyl-2′-deoxyuridine	98
Predicting Liver-Related In Vitro Endpoints with Machine Learning to Support Early Detection of Drug-Induced Liver Injury	82
Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs	69
Recent Advances in DNA Lesion Mapping and Repair Mechanisms	64
Protein Haptenation and Its Role in Allergy	56
Issue Publication Information	54
Issue Publication Information	52
Issue Editorial Masthead	51
Issue Editorial Masthead	51
A Weakly Supervised Deep Learning Framework for Whole Slide Classification to Facilitate Digital Pathology in Animal Study	49
Identification of an Epoxide Metabolite of Amitriptyline In Vitro and In Vivo	49
Surfactant Coformulants in Glyphosate-Based Herbicides: Current Gaps, and Paths Forward in Human Biomonitoring	49
Systematic Investigation of CYP3A4 Using Side-by-Side Comparisons of Apo, Active Site, and Allosteric-Bound States	48
Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides	47
Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy	44
Cellular Interactions and Fatty Acid Transporter CD36-Mediated Uptake of Per- and Polyfluorinated Alkyl Substances (PFAS)	43
Mechanistic Insights into Toxicity of Titanium Dioxide Nanoparticles at the Micro- and Macro-levels	41
Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction	41
Dissecting the Enantioselective Neurotoxicity of Isocarbophos: Chiral Insight from Cellular, Molecular, and Computational Investigations	39
LA-ICP-MS and Immunohistochemical Staining with Lanthanide-Labeled Antibodies to Study the Uptake of CeO₂ Nanoparticles by Macrophages in Tissue Sections	37
Electrochemical Simulation of the Oxidative Capsaicin Metabolism	36
A Review on the Recent Applications of Deep Learning in Predictive Drug Toxicological Studies	36
Alternaria alternata Mycotoxins Activate the Aryl Hydrocarbon Receptor and Nrf2-ARE Pathway to Alter the Structure and Immune Response of Colon Epithelial Cells	35
In Vitro and In Vivo Analysis of Fentanyl and Fentalog Metabolites using Hyphenated Chromatographic Techniques: A Review	34

Quantum Mechanical Assessment of Nitrosamine Potency	31
Coumarin-Based Noncytotoxicity Fluorescent Dye for Tracking Actin Protein in In-Vivo Imaging	31
Issue Editorial Masthead	30
Response to ‘Comments on “Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of Commercial Little Cigars”’ Letter to Editor	30
Issue Editorial Masthead	30
Issue Editorial Masthead	29
Issue Editorial Masthead	29
Products Generated by Amine-Catalyzed Strand Cleavage at Apurinic/Apyrimidinic Sites in DNA: New Insights from a Biomimetic Nucleoside Model System	28
Modeling the Toxicokinetics of Suspensions of Soluble Metallic Nanomaterials	28
ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics	28
The Toxicity of Poly(acrylonitrile-styrene–butadiene) Microplastics toward Hyalella azteca Is Associated with Biofragmentation and Oxidative Stress	27
Structural Elucidation of Agrochemical Metabolic Transformation Products Based on Infrared Ion Spectroscopy to Improve In Silico Toxicity Assessment	27
Assessing the Toxicity of Terpene- and Amino Acid-Based Natural Deep Eutectic Solvents	27
Photosensitized Oxidation of Free and Peptide Tryptophan to N-Formylkynurenine	26
Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash	26
LC–MS/MS Analysis of Reaction Products of Arginine/Methylarginines with Methylglyoxal/Glyoxal	26
Prediction of Cytochrome P450 Substrates Using the Explainable Multitask Deep Learning Models	26
Issue Publication Information	26
Conditional Binding of Arsenic Trioxide (ATO) to Cysteine-Rich Zinc Finger Motifs within RBCC Domain of PML Protein	26
Leveraging Cell Painting Images to Expand the Applicability Domain and Actively Improve Deep Learning Quantitative Structure–Activity Relationship Models	26
Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury	25
Federated Learning in Computational Toxicology: An Industrial Perspective on the Effiris Hackathon	24
Predictive Modeling of DNA Damage Outcomes: Classification of Mutational Determinants Using Augmented Machine Learning Techniques	24
2,2′,4,4′-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPARγ Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation	23
Advancing Drug Safety in Drug Development: Bridging Computational Predictions for Enhanced Toxicity Prediction	23
Quantum-Mechanical Approach to Predicting the Carcinogenic Potency of N -Nitroso Impurities in Pharmaceuticals	23
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N′-Nitrosonornicotine (NNN) in the Rat	23
Issue Editorial Masthead	23
Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01	23
Computational Prediction of Metabolic α-Carbon Hydroxylation Potential of N -Nitrosamines: Overcoming Data Limitations for Carcinogenicity Assessment	23
HDAC6-Mediated NLRP3 Inflammasome Activation Is Involved in Nickel Nanoparticle-Induced Pulmonary Inflammation and Fibrosis	23
Nucleophilic Thiol Proteins Bind Covalently to Abasic Sites in DNA	22
Issue Publication Information	22
Issue Publication Information	22
Capturing Differential Quality of Experimental Evidence in a Predictive Quantum-Mechanical Model for Respiratory Sensitization	22
Nontargeted Analysis in Tobacco Research: Challenges and Opportunities	22
Melatonin Vapes Contain Potential Contaminants and Alter the Human Bronchial Epithelial Transcriptome	21
Integrative Data Mining Approach: Case Study with Adverse Outcome Pathway Network Leading to Pulmonary Fibrosis	21
Chemoproteomic Approach for Identifying Nuclear Arsenite-Binding Proteins	21
Zebrafish Larvae as a Predictive Model for the Risk of Chemical-Induced Cholestasis: Phenotypic Evaluation and Nomogram Formation	21
Detection of Trace Skin Sensitizers Using Novel Nucleophiles with Quaternary Ammonium by Liquid Chromatography–Mass Spectrometry	21
Free Radicals in Little Cigar Mainstream Smoke and the Potential Influence of Flavoring Chemicals on Free Radical Production	21
Photo-oxidation and Photoreduction of Catechols by Chlorophyll Metabolites and Methylene Blue	20
Deep Learning Models Compared to Experimental Variability for the Prediction of CYP3A4 Time-Dependent Inhibition	20
Acrylamide-Aggravated Liver Injury by Activating Endoplasmic Reticulum Stress in Female Mice with Diabetes	20
Circular RNAs: A Potential Regulator in Environmental Chemical Carcinogenesis	20
CYP3A4-Mediated Metabolic Activation and Cytotoxicity of Chlortoluron	20
Dopamine Release Impairments Accompany Locomotor and Cognitive Deficiencies in Rotenone-Treated Parkinson’s Disease Model Zebrafish	19
Navigating Transcriptomic Connectivity Mapping Workflows to Link Chemicals with Bioactivities	19
Aldehyde-Associated Mutagenesis─Current State of Knowledge	19

The Genotoxicity of Stress	18
Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[def,p]chrysene in Human Oral Cells	18
Simultaneous Quantification of Biomarkers for Bis-(2-chloroethyl) Sulfide and 1,2-Bis(2-chloroethylthio) Ethane Exposure in Human Urine at Trace Exposure Levels by Gas Chromatography Tandem Mass Spect	18
Call for Papers for a Special Issue on Mass Spectrometry Advances for Environmental and Human Health	18
Diethylhexyl Phthalate and Bisphenol A Promote Vincristine and Tamoxifen Resistancein Vitro	18
Heterogeneous Oxidation Products of Fine Particulate Isoprene Epoxydiol-Derived Methyltetrol Sulfates Increase Oxidative Stress and Inflammatory Gene Responses in Human Lung Cells	18
Characterization of a Novel Thermostable DNA Lyase Used To Prepare DNA for Next-Generation Sequencing	18
Cytocompatibility of Ti₃C₂T_x MXene with Red Blood Cells and Human Umbilical Vein Endothelial Cells and the Underlying Mechanisms	18
Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6	17
Cell Painting and Chemical Structure Read-Across Can Complement Each Other for Rat Acute Oral Toxicity Prediction in Chemical Early Derisking	17
Role of Human Aldo–Keto Reductases in the Nitroreduction of 1-Nitropyrene and 1,8-Dinitropyrene	17
Increased JUUL Emissions from Initial Puffs after Removing and Reinserting Pod	17
Introduction to the Special Issue: AI Meets Toxicology	17
A Photoinducible DNA Cross-Linking Agent with Potent Cytotoxicity and Selectivity Toward Triple-Negative Breast Cancer Cell Line	17
Issue Publication Information	17
Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA Adductomics	17
Issue Editorial Masthead	17
Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC–MS Analyses	17
Novel In Vitro Intestinal Microbiome Model to Study Lipidomic and Metabolomic Adaptations Due to Exposure to Glyphosate, Perfluorooctanoic Acid, and Docusate Sodium	17
RNA Oxidative Damage by the Iron-Fenton Reaction is Influenced by Bicarbonate Concentration and Ligand Strength	17
Correction to “Use of Structural Alerts for Reactive Metabolites in the Application SpotRM”	17
Phthalate Exposure: Prevalence, Health Effects, Regulatory Frameworks, and Remediation	16
New Aminobiphenylcysteine Derivatives in Globin and Urine of Rats Dosed with 4-Aminobiphenyl, a Tobacco Smoke Carcinogen	16
Photosensitizing Properties of the Topical Retinoid Drug Adapalene	16
Activation of V-Domain Immunoglobulin Suppressor of T-Cell Activation by Baloxavir Marboxil Ameliorates Systemic Lupus Erythematosus through Inhibiting Lysophosphatidylcholine/CD40 Ligand	16
Binding of Per- and Polyfluoroalkyl Substances to β-Lactoglobulin from Bovine Milk	16
Natural Products in Redox Toxicology	16
Spatiotemporal Visualization of Paraquat Distribution, Toxicokinetics, and Its Detoxification in Zebrafish Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging	15
Issue Editorial Masthead	15
Tox24 Challenge	15
Correction to “Structure-Based Reactivity Profiles of Reactive Metabolites with Glutathione”	15
Issue Publication Information	15
One-Week Kava Dietary Supplementation Increases Both Urinary N- and O-Glucuronides of NNAL, a Lung Carcinogen Major Metabolite, among Smokers	15
Issue Publication Information	15
Issue Editorial Masthead	15
Computer-Aided Discovery and Redesign for Respiratory Sensitization: A Tiered Mechanistic Model to Deliver Robust Performance Across a Diverse Chemical Space	14
Facile Biological Oxidation of Dopamine to 6-Hydroxydopamine p-Quinone in a Sequential Two-Step Process: Implications for Parkinson’s Disease	14
Examining Metal Contents in Primary and Secondhand Aerosols Released by Electronic Cigarettes	14
Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis	14
N-Doped Graphene for Biomedical Applications: A Comparative Biocompatibility Assessment of Green and Chemical Exfoliation	14
Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi	14
Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes	14
8-Oxo-2′-deoxyguanosine Replication in Mutational Hot Spot Sequences of the p53 Gene in Human Cells Is Less Mutagenic than That of the Corresponding Formamidopyrimidine	14
Nuclear DNA and Mitochondrial Damage of the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Human Neuroblastoma Cells	14
Hazard Profiling of Commercially Relevant Quantum Dot Components Revealed Synergistic Interactions between Heavy Metals and Polymers	14
Women in Toxicology Special Issue	14
Interindividual Variability in Cytochrome P450 3A and 1A Activity Influences Sunitinib Metabolism and Bioactivation	14
A Computational Approach for Respiratory Hazard Identification of Flavor Chemicals in Tobacco Products	14
Idiosyncratic Drug Reactions: A 35-Year Chemical Research in Toxicology Perspective	14
Cannabidiol Toxicity Driven by Hydroxyquinone Formation	13
Profiling How the Gut Microbiome Modulates Host Xenobiotic Metabolism in Response to Benzo[a]pyrene and 1-Nitropyrene Exposure	13
Human Keratinocyte Responses to Woodsmoke Chemicals	13
Interview with Professor Cynthia J. Burrows, 2022 Founders Award Winner, American Chemical Society Division of Chemical Toxicology	13
Histotoxicity of AIEgen Based on Triphenylamine for the Simultaneous and Discriminatory Sensing of Hg²⁺ and Ag⁺ Directly in Aqueous Media for Environmental Applications	13
Mechanisms Mediating the Combined Toxicity of Paraquat and Maneb in SH-SY5Y Neuroblastoma Cells	13
Recent Contributions of Mass Spectrometry-Based “Omics” in the Studies of Breast Cancer	13
Chemoproteomic Approach for the Quantitative Identification of Arsenic-Binding Proteins	13
Chlorogenic Acid Alleviates Early-Life GenX Exposure-Induced Neurotoxicity via Decreasing Lipopolysaccharide-Induced Pyroptosis by the Systemic Translocation and Suppressing the PI3K/AKT/NF-κB Pathway	13
Nicotine Dosimetry in Evaluating Electronic Cigarettes Compared to Cigarette Smoking: Implications for Tobacco Regulatory Science	13
Cadmium Exposure and Cardiovascular Diseases	13
Dissolution Rate of Nanomaterials Determined by Ions and Particle Size under Lysosomal Conditions: Contributions to Standardization of Simulant Fluids and Analytical Methods	13
Honoring Larry Marnett, Founding Editor of Chemical Research in Toxicology	13
Quantification of Intracellular DNA–Protein Cross-Links with N7-Methyl-2′-Deoxyguanosine and Their Contribution to Cytotoxicity	13
P38 MAPK, NF-κB, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression	12
Pyrroloquinoline Quinone Chemistry, Biology, and Biosynthesis	12
Phthalate Exposure and Coronary Heart Disease: Possible Implications of Oxidative Stress and Altered miRNA Expression	12
Correction to “Oxymatrine Inhibits Liver Cancer Progression by Regulating SIRT1/YY1/GPX4 Axis-Mediated Ferroptosis”	12
The Challenge and Opportunity to Rationally Design Safer Commercial Chemicals	12
Machine Learning Models for Predicting Cytotoxicity of Nanomaterials	12
Quantitation of Ten Urinary Nicotine Metabolites, Including 4-Hydroxy-4-(3-pyridyl) Butanoic Acid, a Product of Nicotine 2′-Oxidation, and CYP2A6 Activity in Japanese Americans, Native Hawaiians, and	12
Liver and Intestinal Fatty Acid Binding Proteins Are Not Critical for Perfluorooctanesulfonate (PFOS) Tissue Distribution and Elimination in Mice	12
CYP2A6 Activity and Deuterated 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Metabolism in Cigarette Smokers	12
Effects of E-Cigarette Flavor Enhancing Capsules on Inhalable Aerosols	12
High-Field Asymmetric Waveform Ion Mobility Spectrometry Analysis of Carcinogenic Aromatic Amines in Tobacco Smoke with an Orbitrap Tribrid Mass Spectrometer	12
Production of Peroxymonocarbonate by Steady-State Micromolar H₂O₂ and Activated Macrophages in the Presence of CO₂/HCO₃^– Evidenced by Boronate Pr	12
Modelling In vitro Mutagenicity Using Multi-Task Deep Learning and REACH Data	12
Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis	12
A New Explanation for the Mystery of Rasputin’s Survival of Cyanide Poisoning: Eating Raw Garlic	12
Inhibitory Effects of Alkaloids on OATP1B1 In Vitro and In Vivo: Prediction for Food/Herb–Drug Interactions and Hepatoprotective Effects Based on Structure–Activity Relationships	12
Antioxidant Activity and Skin Sensitization of Eugenol and Isoeugenol: Two Sides of the Same Coin?	11

Prediction of Internal Exposures after Virtual Oral Doses of Disparate Chemicals in Rats and Humans Using Simplified Physiologically Based Pharmacokinetic Models with In Silico-Generated Input	11
The Dawn of a New Era in Drug Discovery? Drug Screening and the Increasing Biological Complexity of Testing Models	11
Carbonyls and Aerosol Mass Generation from Vaping Nicotine Salt Solutions Using Fourth- and Third-Generation E-Cigarette Devices: Effects of Coil Resistance, Coil Age, and Coil Metal Material	11
Human CYP2C19 Substrate and Inhibitor Characterization of Organophosphate Pesticides	11
Increased Levels of the Acrolein Metabolite 3-Hydroxypropyl Mercapturic Acid in the Urine of e-Cigarette Users	11
Special Issue on Tobacco: Chemistry, Mechanisms, Biomarkers and Disease Prevention	11
Comparative Study of Molecular Descriptors and AI-Based Embeddings for Toxicity Prediction	11
Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice	11
Multiplatform Metabolomics to Understand the Imidacloprid-Induced Toxicity in Drosophila	11
Chlorobenzoquinones Aggravate RSL3-Induced Ferroptosis in ROS-Dependent Manner	11
Nucleophilic Addition of Thiols to Methacrylates for Biomedical Applications Revisited	11
New Insights into the Phototoxicity of Anthracene-Based Chromophores: The Chloride Salt Effect	11
Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating CD36 Upregulation	11
Evidence for the Metabolic Activation of Deferasirox In Vitro and In Vivo	10
8-OxodGuo and Fapy•dG Mutagenicity in Escherichia coli Increases Significantly when They Are Part of a Tandem Lesion with 5-Formyl-2′-deoxyuridine	10
Issue Publication Information	10
MlrA, an Essential Enzyme for Microcystins and Nodularin on First Step Biodegradation in Microcystin-Degrading Bacteria	10
Combining Molecular Docking and Pharmacophore Models Predicts Ligand Binding of Endocrine-Disrupting Chemicals to Nuclear Receptors	10
Is Baikiain in Tara Flour a Causative Agent for the Adverse Events Associated with the Recalled Frozen French Lentil & Leek Crumbles Food Product? - A Working Hypothesis	10
Call for Papers: Special Issue on Nucleic Acid Modifications	10
Evaluation of Six Aromatic Amines in the Mainstream Smoke of Commercial Cigars	10
Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-Null, and CYP2A6-Humanized Mice	10
Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct	10
Searching for LINCS to Stress: Using Text Mining to Automate Reference Chemical Curation	10
Inhibition of Nicotine Metabolism by Cannabidiol (CBD) and 7-Hydroxycannabidiol (7-OH-CBD)	10
Assessment of the Exposure to Tobacco-Specific Nitrosamines and Minor Tobacco Alkaloids in Users of Various Tobacco/Nicotine Products	10
Pesticides Inhibit Retinoic Acid Catabolism in PLHC-1 and ZFL Fish Hepatic Cell Lines	10
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes	10
Chemical Exposures and Impact on Health	10
Identification of the Major Product of Guanine Oxidation in DNA by Ozone	10
Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking	10
Issue Publication Information	10
Ambient Fine Particulate Matter and Cancer: Current Evidence and Future Perspectives	10
Polyamine Adducts with AP Sites: Interaction with DNA Polymerases and AP Endonucleases	10
Isotope Labeling Mass Spectrometry to Quantify Endogenous and Exogenous DNA Adducts and Metabolites of 1,3-Butadiene In Vivo	10
In Vitro Evaluation of DNA Damage Effect Markers toward Five Nitrogen Mustards Based on Liquid Chromatography–Tandem Mass Spectrometry	10
Introducing the Inaugural Early Career Board for Chemical Research in Toxicology	9
Review of the Protective Effects of Selenium against T-2 Toxin-Induced Toxicity	9
Quantification of Flavors, Volatile Organic Compounds, Tobacco Markers, and Tobacco-Specific Nitrosamines in Heated Tobacco Products and Their Mainstream Aerosol	9
Ratiometric Fluorescent Probe for the Detection of Nanomolar Phosgene in Solution and Gaseous Phase: Advancing Crime Detection Applications	9
Issue Publication Information	9
Nature-Derived Epoxy Resin Monomers with Reduced Sensitizing Capacity─Isosorbide-Based Bis-Epoxides	9
Synergistic Interaction of Polycyclic Aromatic Hydrocarbons, Phthalate Esters, or Phenol on DNA Adduct Formation by Aristolochic Acid I: Insights into the Etiology of Balkan Endemic Nephropathy	9
The Human Glyoxalase Gene Family in Health and Disease	9
Mixtures-Inclusive In Silico Models of Ocular Toxicity Based on United States and International Hazard Categories	9
Data Exploration for Target Predictions Using Proprietary and Publicly Available Data Sets	9
Identification of Metoprolol Tartrate-Derived Reactive Metabolites Possibly Correlated with Its Cytotoxicity	9
Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1,8-Dinitropyrene and Its Metabolite 1-Amino-8-nitropyrene via Nitroreduction in Human	9
Free Radicals in Cannabis Smoke	9
Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World	9
Metabolic Characterization of Sarin, Cyclosarin, and Novichoks (A-230, A-232) in Human Liver Microsomes	9
Migration of Soluble Polymers in Human Saliva during Swabbing Characterized by Direct Electrospray Ionization Mass Spectrometry	9
Issue Editorial Masthead	9
Improving Volatile Organic Compound Exposure Assessment Using Biomonitoring by Relating Exposure Biomarker Levels in Blood and Urine	9
Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1	9
Toxic Effects of Cobalt on Erythroid Progenitor Cells	8
High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter	8
MetSim: Integrated Programmatic Access and Pathway Management for Xenobiotic Metabolism Simulators	8
Evaluating the Toxicity of Electronic Cigarette Aerosols for Firsthand and Secondhand Exposure Under Different Device Operating Conditions	8
Issue Editorial Masthead	8
Carbonyl Emissions and Heating Temperatures across 75 Nominally Identical Electronic Nicotine Delivery System Products: Do Manufacturing Variations Drive Pulmonary Toxicant Exposure?	8
Nuclear SUMOylation and Proteotoxic Stress Responses to Metals with Different Ligand Preferences	8
Influence of Nitrite on Formation of Tobacco-Specific Nitrosamines in Electronic Cigarette Liquids and Aerosols	8
The Potential Contribution of Hexavalent Chromium to the Carcinogenicity of Chrysotile Asbestos	8
Network Pharmacology Combined with Metabolomics Approach to Investigate the Toxicity Mechanism of Paclobutrazol	8
Effects of N7-Alkylguanine Conformation and Metal Cofactors on the Translesion Synthesis by Human DNA Polymerase η	8
Interview with Dr. Wei Yang, 2022 Keynote Speaker, American Chemical Society Division of Chemical Toxicology	8
Identification of Specific Hemoglobin Adduct Patterns in Users of Different Tobacco/nicotine Products by Nontargeted GC–MS/MS Analysis	8
Conformation-Dependent Lesion Bypass and Mutagenicity of Bulky 2-Acetylaminofluorene-Guanine DNA Adduct in Epigenetically Relevant Sequence Contexts	8
A Virtual Issue of Chemical Research in Toxicology in Celebration of the International Day of Women and Girls in Science	8
A Membrane Biophysics Perspective on the Mechanism of Alcohol Toxicity	8
Conformation and Pairing Properties of anO⁶-Methyl-2′-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA	8
Issue Editorial Masthead	8
Halogen Atoms in Bisphenol A Derivatives Enhance the Inhibitory Potency against Human and Rat Placental 3β-Hydroxysteroid Dehydrogenases	8
Quantum Chemical Evaluation and QSAR Modeling of N-Nitrosamine Carcinogenicity	8
Untargeted DNA Adductomics Identifies Aristolochic Acid III as a Potent DNA-Damaging Agent among 11 Substituted Aromatic Genotoxicants in the Rat Urinary System	8
Urinary Profile of Alkylated DNA Adducts and DNA Oxidative Damage in Sulfur Mustard-Exposed Rats Revealed by Mass Spectrometry Quantification	8
Driving to a Better Understanding of Acyl Glucuronide Transformations Using NMR and Molecular Modeling	8
Dried Matrix Spots: An Underutilized and Unexplored Technology in India	8
Potential Role of Heterocyclic Aromatic Amines in Neurodegeneration	8
Advances on the Influence of Methylmercury Exposure during Neurodevelopment	8
Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements	8
A Novel Inhibitor of Poly(ADP-Ribose) Polymerase-1 Inhibits Proliferation of a BRCA-Deficient Breast Cancer Cell Line *via* the DNA Damage–Activated cGAS–STING	8
Effect of Butyrate on Food-Grade Titanium Dioxide Toxicity in Different Intestinal In Vitro Models	7
Active Binding Modes of Caffeine with Cytochrome P450 1A2 Determine Its Metabolite Profiles	7
Effects of Heavy Metal Co-Exposure on the formation of DNA Adducts from Aristolochic Acid I: Implications for Balkan Endemic Nephropathy Development	7
Replication Studies of Alkyl Phosphotriester Lesions in Human Cells	7
Development of Comprehensive Ultraperformance Liquid Chromatography–High-Resolution Mass Spectrometry Assays to Quantitate Cisplatin-Induced DNA–DNA Cross-Links	7
Relationships between the Structure and Severe Drug-Induced Liver Injury for Low, Medium, and High Doses of Drugs	7
A Reversible Mechanochromic AIEgen Based on Triphenylamine for the Selective Detection of Vitamin B2 (Riboflavin) in Aqueous Media and Histotoxicity	7
Imidazole-Based ALK5 Inhibitor Attenuates TGF-β/Smad-Mediated Hepatic Stellate Cell Activation and Hepatic Fibrogenesis	7
Molecular Insights into Propofol’s Neurotoxic Effects: Targeting the HTR1A/cAMP Signaling Pathway	7
The Good, The Bad, and The Perplexing: Structural Alerts and Read-Across for Predicting Skin Sensitization Using Human Data	7
Power in Numbers: The Gut Microbiome Takes the Spotlight	7
Formation of Redox-Active Duroquinone from Vaping of Vitamin E Acetate Contributes to Oxidative Lung Injury	7