Immunopharmacology and Immunotoxicology

Papers
(The median citation count of Immunopharmacology and Immunotoxicology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)
ArticleCitations
In vitro anti-tumor activities of a novel recombinant immunotoxin targeting differentially overexpressed Leucine-rich repeat-containing G-protein-coupled receptor 5 in cervical canc46
Assessing the effectiveness of camrelizumab plus anti-angiogenesis drug for the treatment of advanced liver cancer: a single‑center retrospective study31
Moscatilin protects concanavalin A-induced autoimmune liver disease in mice28
Extracellular vesicle-derived LINC00511 promotes glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer through macrophage polarization by microRNA-193a-3p-dependent regulation of27
Sirtinol, a SIRT1 inhibitor, inhibits the EMT and metastasis of 4T1 breast cancer cells and impacts the tumor microenvironment23
Leukoreduced PRP enhanced proliferation and ECM production yet inhibited senescence, inflammation, and multi-differentiation potential of AFSCs by downregulating HMGB123
Corynoline ameliorates dextran sulfate sodium-induced colitis in mice by modulating Nrf2/NF-κB pathway22
Beta-sitosterol alleviates inflammatory culprits and disease severity in arthritic irradiated rat’s model: role of brain-spleen axis22
Galantamine supplementation and rheumatoid arthritis: a systematic review of current research and molecular mechanisms22
Prospective therapeutic targets and recent advancements in the treatment of inflammatory bowel disease21
An overview of the current advances in the treatment of inflammatory diseases using mesenchymal stromal cell secretome20
Inhibition of long-lived plasma cells, a critical role for Telitacicept treatment to systemic lupus erythematosus20
Sevoflurane induces cognitive dysfunction by modulating PER2 methylation to block AKT pathway-suppressed NLRP3 inflammatory vesicle in microglia19
Withaferin A suppressed hepatocellular carcinoma progression through inducing IGF2BP3/FOXO1/JAK2/STAT3 pathway-mediated ROS production19
Correction18
Monotropein alleviates acute pulmonary embolism in rats by inhibiting the NF-κB pathway18
Neutrophil Extracellular Traps (NET) and SARS-CoV-218
Protective effect of pregabalin on renal and renal endothelial damage in sepsis induced by lipopolysaccharide17
Aryl-Cyclohexanone as a potential CB2 agonist: in vitro and in silico evidence in inflammatory modulation17
Role of oncostatin M and its receptor in the inflammatory pathogenesis of graves’ orbitopathy16
Sirt1/Nrf2/TNFα; TLR4/Myd88/NF-κB signaling pathways are involved in mediating hepatoprotective effect of bupropion in rat model of myocardial infarction16
Silver nanoparticle–conjugated pyrimidine-based BN6 methanimine derivative improves DSS-induced inflammatory bowel disease in zebrafish16
Systematic review of the efficacy and safety of lenvatinib in various solid tumors15
mTORC1 inhibition may improve T lymphocytes affected by aging15
Thymosin α1 improves the outcomes of patients with hepatitis B virus-related acute-on-chronic liver failure by restoring immune balance14
Dapagliflozin alleviates thioacetamide induced-liver fibrosis in rats via controlling the Nrf2/HO-1 and TLR4/TGF-β1/PI3K signaling pathways14
Correction14
Cancer-associated immune cells and their modulation by melatonin14
Losartan ameliorates premature ovarian failure by regulation of the Sirti1/NF-κB pathway in female albino rats14
Immunotherapeutic potentials of carnosol against lipopolysaccharides-induced acute inflammatory reactions in White Swiss albino mice14
SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-κB signaling pathway13
Celecoxib alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis13
Hydroxychloroquine ameliorates immune functionality and intestinal flora disorders of IgA nephropathy by inhibition of C1GALT1/Cosmc pathway13
Baicalin suppresses interleukin-1β-induced apoptosis, inflammatory response, oxidative stress, and extracellular matrix degradation in human nucleus pulposus cells12
CircRNA circ-PDCD11 is highly expressed in lung large-cell carcinoma and predicts poor survival12
Astragaloside IV restores Th17/Treg balance via inhibiting CXCR4 to improve chronic obstructive pulmonary disease11
Selective and effective suppression of pancreatic cancer through MNK inhibition11
Molecular mechanisms mediate roflumilast protective effect against isoprenaline-induced myocardial injury11
Clinical characteristics, treatment, and prognosis of ixekizumab-induced inflammatory bowel disease10
Association between serum baseline C1q and IgG levels and the efficacy of combined immunotherapy in patients with esophageal squamous cell carcinoma: a retrospective study10
Two flavonoids, baicalein and naringin, are effective as anti-inflammatory and anti-oxidant agents in a rat model of polymicrobial sepsis10
The effect of Vortioxetine on the NLRP3 pathway and microglial activity in the prefrontal cortex in an experimental model of depression10
Anticolitis effect of febuxostat. The imperative role of NLRP-3/Caspase-1/IL-1β pathway via histopathological, immunohistochemical and biochemical approach10
Forkhead box A1 induces angiogenesis through activation of the S100A8/p38 MAPK axis in cutaneous wound healing9
Glucocorticoid receptor signaling: crosstalk with inflammation9
Cannabis sativa alleviates experimentally acetic acid- induced ulcerative colitis in rats: targeting CB1/SIRT/MAPK signaling pathways9
Gigantol protects retinal pigment epithelial cells against high glucose-induced apoptosis, oxidative stress and inflammation by inhibiting MTDH-mediated NF-kB signaling pathway9
Correction9
IGF2BP3 aggravates lung adenocarcinoma progression by modulation of PI3K/AKT signaling pathway9
T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction9
Role of EGF/ERK1/2/HO-1 axis in mediating methotrexate induced testicular damage in rats and the ameliorative effect of xanthine oxidase inhibitors8
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway8
Galectin-1-producing mesenchymal stem cells restrain the proliferation of T lymphocytes from patients with systemic lupus erythematosus8
Cardioprotective effect of tofisopam against isoprenaline-induced myocardial infarction in rats via modulation of NLRP3\IL-1β\caspase-1 pathway8
Luteolin restored Treg/Th17 balance to ameliorate allergic rhinitis in a mouse model8
Prognostic values of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in the early prediction of aluminum phosphide-poisoned patients’ outcomes8
Systemic administration of interleukin-10 is associated with dose-dependent toxicities in Wistar albino rats8
Seasonal facial erythema in a patient with allergic rhinitis treated using a combination of tranilast and roxithromycin8
Occupational exposure to pesticides affects systemic cytokine profile and correlates with poor clinical prognosis in young women with breast cancer8
Kindlin-2 silencing promoted apoptosis and cell cycle arrest through the fas/FasL pathway in hepatocellular carcinoma7
Evaluation of the inhibitory effect of different molecular weights chitosan on MRGPRX2-mediated mast cell degranulation and the pseudo-allergic reaction7
Rituximab beyond oncology: targeting B-cell-mediated immunomodulatory therapy in neurodegenerative and neuropsychiatric disorders7
Nanocarriers for lung health: ameliorating inflammation and cell aging using flavonoid-based nano nutrients7
Impact of glucocorticoids on interstitial lung disease: a medical information mart for intensive care and Mendelian randomization study7
Leptin/lipopolysaccharide-treated dendritic cell vaccine improved cellular immune responses in an animal model of breast cancer7
Impact of interleukin-32α on T helper cell-related cytokines, transcription factors, and proliferation in patients with type 2 diabetes mellitus7
Investigating the therapeutic efficacy of physical exercise on tumor immunity in a mouse model of malignant colon cancer7
Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes7
Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway7
Targeting alpha 7 nicotinic acetylcholine receptors by galantamine alleviates doxorubicin-induced cardiotoxicity via modulation of PI3K/AKT, Bax/Bcl-2, a7
Nodakenin attenuates cerebral ischemia–reperfusion injury by modulating the PI3K/AKT/NF-κB signaling pathway7
Time to treat the climate and nature crisis as one indivisible global health emergency7
Endoplasmic reticulum stress is upregulated in inflammatory bowel disease and contributed TLR2 pathway-mediated inflammatory response7
Efficacy and safety of the combined use of ipilimumab and nivolumab for melanoma patients with brain metastases: a systematic review and meta-analysis7
Therapeutic efficacy of tofacitinib in PDSAg-induced chronic experimental autoimmune uveitis in Wistar rat7
All- trans retinoic acid ameliorates S100-induced experimental autoimmune hepatitis by regulating the Treg/Th17 balance7
Expression of calcitonin gene-related peptide in atopic dermatitis and correlation with distress7
Vildagliptin attenuates doxorubicin-induced hepatotoxicity via activating Nrf2/HO-1 and SIRT1 and suppressing NF-κB signals in rats6
Febuxostat attenuates cyclophosphamide-induced ovarian toxicity; role of TLR4/NFκB/NLRP3 signaling pathway in female wistar albino rats6
The anti-inflammatory activity and toxicological safety of synthetic chalcone derivatives in preclinical trials6
The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats6
The anti-inflammatory effects of vitamin B6 on neuroinflammation and neuronal damage caused by 1,2-diacetylbenzene in BV2 microglial and sH-SY5Y cells6
Fumaric acid per se and in combination with methotrexate arrests inflammation via moderating inflammatory and oxidative stress biomarkers in arthritic rats6
Investigation of the therapeutic potential of recombinant bispecific bivalent anti-PD-L1/VEGF nanobody in inhibition of angiogenesis6
Studying the effect of chronic toxicity of monosodium glutamate on interleukin-10 and interleukin-17 in albino Wistar rats6
Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats6
Safety assessment of voclosporin: a real-world disproportionality analysis of the FAERS database6
α-Cyperone ameliorates depression in mammary gland hyperplasia and chronic unpredictable mild stress rat by regulating hormone, inflammation, and oxidative stress5
Breviscapine inhibits the proliferation and immune escape of diffuse large B-cell lymphoma cells by regulating JAK2/STAT3/PD-L1 pathway5
Immunomodulatory effect of vitamin D supplementation on Behçet’s disease patients: effect on nitric oxide and Th17/Treg cytokines production5
A comparative analysis of MSCs and their exosomes in osteoarthritis therapy: complementary roles and clinical translation5
The transcriptomic profile shows the protective effects of celecoxib on cirrhotic splenomegaly5
Thiolutin, a selective NLRP3 inflammasome inhibitor, attenuates cyclophosphamide–induced impairment of sperm and fertility in mice5
Sodium hyaluronate and pranoprofen improve visual function and reduce inflammation in patients with dry eye5
The dual potential of topical roflumilast: advancing psoriasis therapy and pioneering oral mucosal disease treatment5
Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression5
Reno-protective impact of diosmin and perindopril in amikacin-induced nephrotoxicity rat model: modulation of SIRT1/p53/C-FOS, NF-κB-p65, and keap-1/Nrf2/HO-1 signaling pathways5
The protective effect of butylated hydroxytoluene and 3-hydroxytyrosol on food allergy in mice5
Compound glycyrrhiza oral solution alleviates oxidative stress and inflammation by regulating SRC/MAPK pathway in chronic obstructive pulmonary disease5
Unexplained lymphadenopathy following adjuvant immunotherapy in a non-small cell lung cancer patient: a literature review and a rare case report5
Sotrovimab therapy in solid organ transplant recipients with mild to moderate COVID-19: a systematic review and meta-analysis5
The therapeutic potential of jaceosidin: a comprehensive review of its effects on chronic diseases5
Acute kidney injury associated with anti-PD-1 and anti-PD-L1 drugs: a meta-analysis of randomized clinical trials5
Amygdalin alleviates atopic dermatitis-like skin inflammation via inhibition of Th2 immune responses5
Sulforaphane suppresses skin squamous cell carcinoma cells proliferation through miR-199a-5p/Sirt1/CD44ICD signaling pathway5
Vinpocetine mitigates methotrexate-induced duodenal intoxication by modulating NF-κB, JAK1/STAT-3, and RIPK1/RIPK3/MLKL signals5
Multi-omics profiling uncovers candidate genes for the treatment of graves’ disease5
Evaluation of HER-2 positive breast cancer treated with dual-targeted treatment of trastuzumab plus pertuzumab5
A comparison of panitumumab and cetuximab in the treatment of KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis5
Randomized double-blinded controlled trial on the effect of synbiotic supplementation on IL-17/IL-23 pathway and disease activity in patients with axial spondyloarthritis4
Farnesol mitigates methotrexate-induced intestinal toxicity by enhancing SIRT1, PPAR-γ, and Nrf2 signaling and attenuating Bax/cytochrome c /caspase-3–me4
Morphine upregulates Toll-like receptor 4 expression and promotes melanomas in mice4
Avarol protects HT22 neuronal cells from BV2 microglia cell-derived neuroinflammation in lipopolysaccharide-induction model4
Pre-clinical investigation of protective effect of nutraceutical D-glucosamine on TNBS-induced colitis4
Mastoparan, a wasp venom-derived peptide, promotes healing in Candida albicans -infected wounds through antifungal and anti-inflammatory mechanisms4
Isorhamnetin ameliorates cisplatin-induced acute kidney injury in mice by activating SLPI-mediated anti-inflammatory effect in macrophage4
The effect of omega-3 fatty acids supplementation on inflammatory biomarkers in subjects with migraine: a randomized, double-blind, placebo-controlled trial4
Matrine alleviates the immune imbalance of atopic dermatitis by up-regulating FOXO4 to inactivate circTNFRSF21-mediated JAK/STAT3 axis4
Ginseng polysaccharide promotes the apoptosis of colon cancer cells via activating the NLRP3 inflammasome4
Diethylcarbamazine reduces the viral titer of influenza A (H1N1)pdm09 virus and regulates IFN-β and IL-8 in infected epithelial cells4
Isoliquiritin modulates ferroptosis via NF-κB signaling inhibition and alleviates doxorubicin resistance in breast cancer4
Potential regulation of artesunate on bone metabolism through suppressing inflammatory infiltration in type 2 diabetes mellitus4
Mavorixafor: a CXCR4 antagonist for WHIM syndrome4
Mono(2-ethylhexyl) phthalate modulates bone marrow-derived APCs and exacerbates allergic lung inflammation via PPARγ-dependent pro-inflammatory signaling4
Immuno-regulatory effects of hydroxychloroquine in experimental autoimmune thyroiditis4
miR-155-5p/FOXO3a promotes pulmonary fibrosis in rats by mediating NLRP3 inflammasome activation4
A case report of carboxymethylcellulose allergy: exploring tolerance based on administration route4
Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats4
Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis4
To evaluate the short and long term outcomes of renal transplant recipients with low dose everolimus, tacrolimus-based minimal quadruple immunosuppressive regimen4
Clinical characteristics, treatment, and outcomes of nivolumab-induced uveitis4
The role of PI3K/AKT-related proteins in di(2-ethyl)hexylphthalate-induced BG-1 and MCF-7 cell proliferation, and inhibition by metformin4
Dichapetalin-type triterpenoids inhibits macrophage interferon expression by regulating the cGas-STING pathway, suggesting potential application in immunosuppression3
Is resveratrol really effective in kidney disease?: A different perspective than ever before3
Cannabidiol and low-dose γ-radiation regulate alterations consequences of hepatic-encephalopathy induced by thioacetamide: neuroprotective and anti-inflammatory role3
Alyssin modulates inflammatory mediator expression in TNF-α-stimulated human periodontal ligament cells3
Effect of dapagliflozin on sepsis-induced kidney injury in a rat model: modulation of the NLRP3 pathway3
Correction3
Possible anti-inflammatory, antioxidant, and neuroprotective effects of apigenin in the setting of mild traumatic brain injury: an investigation*3
Galantamine and wedelolactone combined treatment suppresses LPS-induced NLRP3 inflammasome activation in microglial cells3
Medicarpin suppresses thyroid cancer progression by inhibiting the AKT/NF-κB pathway and enhancing CD8 + T cell-mediated antitumor immunity3
Preclinical evaluation of 3,4-dimethoxybenzoic acid alone and in combination for adjuvant-induced arthritis in Wistar rats3
Efficacy and safety of Nivolumab in patients with advanced esophageal, gastroesophageal, and gastric cancers: a meta-analysis of randomized controlled trials3
Correction3
Citicoline modulates inflammatory signaling pathways in the spleen of rats exposed to gamma-radiation3
Implications of inflammasomes in dental pulp inflammation: immunopathology and therapeutic targeting3
Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-13
The AMPK-SIRT1-FoxO1-NF-κB signaling pathway participates in hesperetin-mediated neuroprotective effects against traumatic brain injury via the NLRP3 inflammasome3
Sufentanil inhibits the metastasis and immune response of breast cancer via mediating the NF-κB pathway3
Immune checkpoint inhibitors and immunosuppressive tumor microenvironment: current challenges and strategies to overcome resistance3
Implications of glucocorticoid-induced co-inhibitory molecule expression on combined glucocorticoid and immune checkpoint inhibitor therapy3
Attenuation of adjuvant-induced arthritis with carnosic acid by inhibiting mPGES-1, COX-2, and bone loss in male SD rats3
Intervention of inflammation associated with ankylosing spondylitis by triptolide promotes histone H3 Iys-27 trimethylation3
Functional role of granulocytic myeloid-derived suppressor cells in CAR-T therapy: insights from single-cell RNA sequencing in multiple myeloma3
Statement of Retraction: Amygdalin Induces Apoptosis in Human Cervical Cancer Cell Line HeLa Cells3
Alpha-cyperone ameliorates renal fibrosis and inflammation in mice with chronic kidney disease via NF-κB and Akt/Nrf2/HO-1 pathways3
Human milk oligosaccharide disialyllacto-n-tetraose protects human intestinal epithelium integrity and permeability against mast cell chymase-induced disruption by stabilizing ZO-1/FAK/P38 pathway of 3
Immunomodulatory roles of propofol and sevoflurane in murine models of breast cancer3
Telmisartan and nicorandil attenuate Polymyxin B-induced renal injury by modulating NrF2/NQO1, FAS/FASL signaling, and mitigation of P53, Cyt-C, and caspase-32
Nano-enabled strategies for enhancing cancer immunotherapy: challenges, progress and perspective2
Knockdown of A20 attenuates microglial susceptibility to OGD/R-induced ferroptosis and upregulates inflammatory responses2
Emulsified isoflurane pretreatment attenuates myocardial ischemia-reperfusion injuries by suppressing toll-like Receptor-42
C-phycocyanin acts as a positive immunomodulator in different primary and secondary organs of mice2
A case report and literature review on respiratory failure with immune checkpoint inhibitors: a life-threatening adverse event2
Vildagliptin alleviates cardiomyocyte apoptosis and inflammatory responses in the treatment of non-valvular atrial fibrillation by regulating the NO/sGC/cGMP signaling pathway2
Ezetimibe protects against Gentamycin-induced ototoxicity in rats by antioxidants, anti-inflammatory mechanisms, and BDNF upregulation2
Mannose targeting of poly(lactic-co-glycolic acid): a promising approach for improving sublingual allergen-specific immunotherapy2
Employing cancer driver genes for the identification of immunological features in two esophageal cancer subtypes to facilitate immunotherapy2
Effects of Trigonella foenum graecum (fenugreek) on rheumatoid arthritis: a systematic review2
BACE1 inhibition via miR-6838-5p overexpression inhibits insulin resistance and the immune response in HFD-induced obesity in mice model2
Clinical features, treatment, and outcomes of anti-PD-1/PD-L1 immune checkpoint inhibitors induced dermatomyositis2
Immune checkpoints in hepatocellular carcinoma and the challenges of therapeutic resistance2
Human umbilical-cord-derived mesenchymal stem cells in combination with rapamycin reduce cartilage degradation via inhibition of the AKT/mTOR signaling pathway2
Vinpocetine attenuates 5-fluorouracil-induced intestinal injury: role of the Keap1/Nrf2/HO-1, NF-κB/TLR4/SOCS3 and RIPK1/RIPK3/MLKL signals2
Effect of biological treatment on the thiol/disulfide parameters in patients with axial spondyloarthritis2
Cardamonin inhibits the expression of inflammatory mediators in TNF-α-stimulated human periodontal ligament cells2
KLF5-mediated aquaporin 3 activated autophagy to facilitate cisplatin resistance of gastric cancer2
Eupatilin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like skin lesions in mice via the p38 MAPK/NF-κB signaling pathway2
Identification of immune-associated prognostic biomarkers in lung adenocarcinoma on the basis of gene co-expression network2
Nobiletin derivative, 5-acetoxy-6,7,8,3’,4’-pentamethoxyflavone, inhibits neuroinflammation through the inhibition of TLR4/MyD88/MAPK signaling pathways and STAT3 in microglia2
Liraglutide alleviates sepsis-induced acute lung injury by regulating pulmonary surfactant through inhibiting autophagy2
HIV protease inhibitor saquinavir inhibits toll-like receptor 4 activation by targeting receptor dimerization2
Efficacy and safety of immune checkpoint inhibitors combined with anti-VEGF therapy in the treatment of unresectable or advanced liver cancer: a systematic review2
Protective effect of roflumilast on cyclophosphamide-induced ovarian toxicity in rats: role of SIRT1/Nrf2/nF-ĸB pathway2
Secreted phosphoprotein 1 regulates natural compound 3’,4’,5,7-tetrahydroxyflavone to inhibit mast cell-mediated allergic inflammation2
From the lab to the feed: science communication through an immunological lens in the social media era2
Targeting the cGAS-STING pathway as an inflammatory crossroad in coronavirus disease 2019 (COVID-19)2
Immunotoxicity of silica nanoparticles and the potential role of vitamin C2
Sunitinib alleviates hepatic ischemia reperfusion injury by inhibiting the JAK2/STAT pathway and promoting the M2 polarization of macrophages2
Myricetin attenuates atrazine-induced dysregulation of the hypothalamic-pituitary-adrenal axis of rats via anti-oxidative, anti-inflammatory, and anti-apoptotic mechanisms2
Examination of the effect of riboflavin on TNF-α, Cas-3 expression and SIRT1/p53/bax/bcl-2 gene expression in diatrizoate-induced experimental nephropathy model2
Quinic acid attenuates cisplatin-induced acute kidney injury by modulating inflammatory cytokines, oxidative stress, apoptosis, and the Nrf2/HO-1/NQO1 pathway in rats2
Effects of sulfasalazine in axial spondyloarthritis on COVID-19 outcomes: real-life data from a single center2
CD26 CAR-T cells have attenuated mitochondrial and glycolytic metabolic profiling2
Immunomodulatory and anti-apoptotic effects of pediatric anti-cough and asthma sirup in mice with cigarette smoke extract-induced asthma2
Study on the mechanism of glucocorticoid receptor mitochondrial translocation and glucocorticoid-induced apoptosis in macrophages2
CCL2 regulated by the CTBP1-AS2/miR-335-5p axis promotes hemangioma progression and angiogenesis2
Efficacy and safety of ibuprofen and naproxen in the treatment of oligoarticular juvenile idiopathic arthritis: bi-national cohort study2
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