Immunopharmacology and Immunotoxicology

Article	Citations
Transplantation and immunosuppression: a review of novel transplant-related immunosuppressant drugs	65
Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats	48
Telitacicept as a BLyS/APRIL dual inhibitor for autoimmune disease	48
Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies	42
Protective role of astragaloside IV in gastric cancer through regulation of microRNA-195-5p-mediated PD-L1	31
Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7/miR-34a-5p pathway	31
Topical application of quercetin improves wound repair and regeneration in diabetic rats	27
Protective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression	27
Tranilast: a potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19	26
The antagonistic effect of bisphenol A and nonylphenol on liver and kidney injury in rats	25
Vitexin protects melanocytes from oxidative stress via activating MAPK-Nrf2/ARE pathway	21
Indomethacin attenuates neuroinflammation and memory impairment in an STZ-induced model of Alzheimer’s like disease	20
Bone marrow-mesenchymal stem cell-derived exosomal microRNA-141 targets PTEN and activates β-catenin to alleviate myocardial injury in septic mice	20
Immunomodulatory activity of puerarin in RAW264.7 macrophages and cyclophosphamide-induced immunosuppression mice	19
Inhibitory activity of narirutin on RBL-2H3 cells degranulation	19
Toxic effects of pesticides on cellular and humoral immunity: an overview	19
Effects of treatment with hydroxychloroquine on the modulation of Th17/Treg ratio and pregnancy outcomes in women with recurrent implantation failure: clinical trial	18
Anti-IgE monoclonal antibodies as potential treatment in COVID-19	17
TIMP1 represses sorafenib-triggered ferroptosis in colorectal cancer cells by activating the PI3K/Akt signaling pathway	17
Protective effect of sarsasapogenin in TNBS induced ulcerative colitis in rats associated with downregulation of pro-inflammatory mediators and oxidative stress	17
Statins as an adjunctive therapy for COVID-19: the biological and clinical plausibility	16
MiR-485-3p promotes proliferation of osteoarthritis chondrocytes and inhibits apoptosis via Notch2 and the NF-κB pathway	16
Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4	16
A systematic review on efficacy, safety, and treatment-durability of low-dose rituximab for the treatment of Pemphigus: special focus on COVID-19 pandemic concerns	16
Glycyrrhizic acid, as an inhibitor of HMGB1, alleviates bleomycin-induced pulmonary toxicity in mice through the MAPK and Smad3 pathways	16

Anti-inflammatory effects of paeoniflorin caused by regulation of the hif1a/miR-210/caspase1/GSDMD signaling pathway in astrocytes: a novel strategy for hypoxia-induced brain injury in rats	15
The impact of ellagic acid on some apoptotic gene expressions: a new perspective for the regulation of pancreatic Nrf-2/NF-κB and Akt/VEGF signaling in CCl4-induced pancreas damage in rats	15
The use of neutralizing monoclonal antibodies and risk of hospital admission and mortality in patients with COVID-19: a systematic review and meta-analysis of randomized trials	15
Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway	15
The AMPK-SIRT1-FoxO1-NF-κB signaling pathway participates in hesperetin-mediated neuroprotective effects against traumatic brain injury via the NLRP3 inflammasome	14
Up-regulation of LncRNA UCA1 by TGF-β promotes doxorubicin resistance in breast cancer cells	14
Dioscin promotes autophagy by regulating the AMPK-mTOR pathway in ulcerative colitis	14
Circ_0025033 deficiency suppresses paclitaxel resistance and malignant development of paclitaxel-resistant ovarian cancer cells by modulating the miR-532-3p/FOXM1 network	13
Dexmedetomidine inhibits inflammatory response and oxidative stress through regulating miR-205-5p by targeting HMGB1 in cerebral ischemic/reperfusion	13
Synovial mesenchymal stem cell-derived extracellular vesicles alleviate chondrocyte damage during osteoarthritis through microRNA-130b-3p-mediated inhibition of the LRP12/AKT/β-catenin axis	13
Retinoic acid abrogates LPS-induced inflammatory response via negative regulation of NF-kappa B/miR-21 signaling	12
LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling	12
Lupeol triggers oxidative stress, ferroptosis, apoptosis and restrains inflammation in nasopharyngeal carcinoma via AMPK/NF-κB pathway	12
LncRNA SLC16A1-AS1 regulates the miR-182/PDCD4 axis and inhibits the triple-negative breast cancer cell cycle	12
Silencing lncRNA LINC01410 suppresses cell viability yet promotes apoptosis and sensitivity to temozolomide in glioblastoma cells by inactivating PTEN/AKT pathway via targeting miR-370-3p	12
Regulatory effect of glutathione on treg/Th17 cell balance in allergic rhinitis patients through inhibiting intracellular autophagy	11
Circ_0067934 reduces JNK phosphorylation through a microRNA-545-3p/PPA1 axis to enhance tumorigenesis and cisplatin resistance in ovarian cancer	11
Picroside II alleviates DSS-induced ulcerative colitis by suppressing the production of NLRP3 inflammasomes through NF-κB signaling pathway	11
Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by inducing M1-to-M2 repolarization via the mTOR/STAT3 signaling	11
Carnosol suppresses microglia cell inflammation and apoptosis through PI3K/AKT/mTOR signaling pathway	11
Isoliquiritin modulates ferroptosis via NF-κB signaling inhibition and alleviates doxorubicin resistance in breast cancer	11
Protective effect of naringin ameliorates TNBS‐induced colitis in ratsviaimproving antioxidant status and pro-inflammatory cytokines	11
Wogonoside attenuates the articular cartilage injury and the infiltration of Th1/Th2-type cytokines in papain-induced osteoarthritis in rat model via inhibiting the NF-κB and ERK1/2 activation	11
Fisetin alleviates thioacetamide-induced hepatic fibrosis in rats by inhibiting Wnt/β-catenin signaling pathway	10
Atractylenolide II inhibits tumor-associated macrophages (TAMs)-induced lung cancer cell metastasis	10
Neuroprotective role of camphor against ciprofloxacin induced depression in rats: modulation of Nrf-2 and TLR4	10
Effects of stem cell-derived exosomes on neuronal apoptosis and inflammatory cytokines in rats with cerebral ischemia-reperfusion injury via PI3K/AKT pathway-mediated mitochondrial apoptosis	10
Hecogenin and fluticasone combination attenuates TNBS-induced ulcerative colitis in rats via downregulation of pro-inflammatory mediators and oxidative stress	10
The beneficial effect of salubrinal on neuroinflammation and neuronal loss in intranigral LPS-induced hemi-Parkinson disease model in rats	10
Sulforaphane alleviates LPS-induced inflammatory injury in ARPE-19 cells by repressing the PWRN2/NF-kB pathway	9
Resveratrol protects against ox-LDL-induced endothelial dysfunction in atherosclerosis via depending on circ_0091822/miR-106b-5p-mediated upregulation of TLR4	9
Fraxetin protects rat brains from the cerebral stroke via promoting angiogenesis and activating PI3K/Akt pathway	9
Tofacitinib enhances remyelination and improves myelin integrity in cuprizone-induced mice	9
Lactoferrin suppresses LPS-induced expression of HMGB1, microRNA 155, 146, and TLR4/MyD88/NF-кB pathway in RAW264.7 cells	9
Zinc finger protein A20 regulates the development and progression of osteoarthritis by affecting the activity of NF-κB p65	8
LncRNA JPX contributes to Treg/Th17 imbalance in allergic rhinitis via targeting the miR-378g/CCL5 axis	8
LncRNA H19 acts as miR-301a-3p sponge to alleviate lung injury in mice with sepsis by regulating Adcy1	8
Nrf2/HO-1 pathway is involved the anti-inflammatory action of intrauterine infusion of platelet-rich plasma against lipopolysaccharides in endometritis	8
Presence of anti-TIF-1γ, anti-Ro52, anti-SSA/Ro60 and anti-Su/Ago2 antibodies in breast cancer: a cross-sectional study	8
Protective effects of endotoxin tolerance on peripheral lipopolysaccharide-induced neuroinflammation and dopaminergic neuronal injury	8
Quercetin protects oral mucosal keratinocytes against lipopolysaccharide-induced inflammatory toxicity by suppressing the AKT/AMPK/mTOR pathway	8
Platelet-rich plasma treatment alleviates osteoarthritis-related pain, inflammation, and apoptosis by upregulating the expression levels of microRNA-375 and microRNA-337	8
Repurposing metformin for covid-19 complications in patients with type 2 diabetes and insulin resistance	8
Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19	8
(E)-5-hydroxy-7-methoxy-3-(2′-hydroxybenzyl)-4-chromanone isolated fromPortulaca oleraceaL. suppresses LPS-induced inflammation in RAW 264.7 macrophages by downregulating inflammatory fa	8
Isoquercetin alleviates sleep deprivation dependent hippocampal neurons damage by suppressing NLRP3-induced pyroptosis	8
LINC00174 promotes cell proliferation and metastasis in renal clear cell carcinoma by regulating miR-612/FOXM1 axis	8
Isorhamnetin alleviates lipopolysaccharide-induced acute lung injury by inhibiting mTOR signaling pathway	8
Donepezil protects glycerol-induced acute renal failure through the cholinergic anti-inflammatory and nitric oxide pathway in rats	8
Eupatilin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like skin lesions in mice via the p38 MAPK/NF-κB signaling pathway	8

Efficacy of immunotherapy in obese patients with cancer	7
Circular RNA circCTNNA1 is downregulated in osteoarthritis and sponges miR-29a to suppress LPS-induced apoptosis of synoviocytes	7
2-methoxyestradiol inhibits melanoma cell growth by activating adaptive immunity	7
Interference with lncRNA NEAT1 promotes the proliferation, migration, and invasion of trophoblasts by upregulating miR-411-5p and inhibiting PTEN expression	7
Mycophenolate mofetil enhances the effects of tacrolimus on the inhibitory function of regulatory T cells in patients after liver transplantation via PD-1 and TIGIT receptors	7
Schizandrin ameliorates behavioral disorders in hepatic injury mice via regulation of oxidative stress and neuroinflammation	7
The role of TNF-α and anti-TNF-α agents in the immunopathogenesis and management of immune dysregulation in primary immunodeficiency diseases	7
Mycobacterium bovisBCG-mediated suppression of Th17 response in mouse experimental autoimmune encephalomyelitis	7
Neuroprotective effect of canagliflozin against cisplatin-induced cerebral cortex injury is mediated by regulation of HO-1/PPAR-γ, SIRT1/FOXO-3, JNK/AP-1, TLR4/iNOS, and Ang II/Ang 1–7 signals	7
KLF5-mediated aquaporin 3 activated autophagy to facilitate cisplatin resistance of gastric cancer	7
Inhibition of neovascularisation in human endothelial cells using anti NRP-1 nanobody fused to truncated form of diphtheria toxin as a novel immunotoxin	7
Two flavonoids, baicalein and naringin, are effective as anti-inflammatory and anti-oxidant agents in a rat model of polymicrobial sepsis	7
Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties	7
Triptolide inhibits Th17 differentiation via controlling PKM2-mediated glycolysis in rheumatoid arthritis	7
ARRDC3 inhibits liver fibrosis and epithelial-to-mesenchymal transition via the ITGB4/PI3K/Akt signaling pathway	7
Contribution of long-chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells – induction of MDSC by lipid vesicles (liposome)	6
Potential role of carvedilol in intestinal toxicity through NF-κB/iNOS/COX-2/TNF-α inflammatory signaling pathway in rats	6
Interleukin-39 exacerbates concanavalin A-induced liver injury	6
Investigation of the therapeutic potential of recombinant bispecific bivalent anti-PD-L1/VEGF nanobody in inhibition of angiogenesis	6
MRGPRX2 is critical for clozapine induced pseudo-allergic reactions	6
β-Sitosterol inhibits ovalbumin-induced asthma-related inflammation by regulating dendritic cells	6
MG53 represses high glucose-induced inflammation and angiogenesis in human retinal endothelial cells by repressing the EGR1/STAT3 axis	6
STAT1 mediates the PI3K/AKT pathway through promoting microRNA-18a in nasal polyps	6
Mifepristone regulates Tregs function mediated by dendritic cells through suppressing the expression of TGF-β	6
Ginsenosides Rd monomer inhibits proinflammatory cytokines production and alleviates DSS-colitis by NF-κB and P38MAPK pathways in mice	6
Protective effect of the intravenous anesthetic propofol against a local inflammation in the mouse carrageenan-induced air pouch model	6
Nanocurcumin formulation: a possible therapeutic agent for post COVID inflammatory syndrome	6
Corynoline ameliorates dextran sulfate sodium-induced colitis in mice by modulating Nrf2/NF-κB pathway	6
A comparison of panitumumab and cetuximab in the treatment of KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis	6
LncRNA NEAT1 regulate diffuse large B-cell lymphoma by targeting miR-495-3p/PD-L1 axis	6
The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats	6
17β-Estradiol attenuates inflammation and tendon degeneration in a rat model of Achilles tendinitis	6
The efficacy and safety of Nivolumab combined with Ipilimumab in the immunotherapy of cancer: a meta-analysis	6
MicroRNA-30d-5p ameliorates lipopolysaccharide-induced acute lung injury via activating AMPKα	5
Baicalin suppresses interleukin-1β-induced apoptosis, inflammatory response, oxidative stress, and extracellular matrix degradation in human nucleus pulposus cells	5
Polydatin inhibits LPS-induced inflammatory response in BV2 microglia by disrupting the formation of lipid rafts	5
Possible anti-inflammatory, antioxidant, and neuroprotective effects of apigenin in the setting of mild traumatic brain injury: an investigation*	5
Mechanism of neuroprotective effect of stevioside on cerebral ischemia-reperfusion injury via PPAR-γ activation	5
Sotrovimab therapy in solid organ transplant recipients with mild to moderate COVID-19: a systematic review and meta-analysis	5
Effects of nanocurcumin supplementation on T‐helper 17 cells inflammatory response in patients with Behcet’s disease: a randomized controlled trial	5
The antifibrotic effects of naringin in a hypochlorous acid (HOCl)-induced mouse model of skin fibrosis	5
Different aspects of convalescent plasma therapy for COVID-19 treatment; a critical review	5
What are the immunopharmacological effects of furazolidone? A systematic review	5
Gastrodin ameliorates Concanavalin A-induced acute hepatitis via the IL6/JAK2/STAT3 pathway	5
Sestrin2 suppresses ferroptosis to alleviate septic intestinal inflammation and barrier dysfunction	5
Investigation of the effect of IFN-γ/TNF-α-treated mesenchymal stem cells on Th9- and Treg cell-related parameters in a mouse model of ovalbumin-induced allergic asthma	5
Impact of dietary exposure to low-dose tris(1,3-dichloro-2-propyl)phosphate in allergic asthmatic mice	5
Role of IL-6/STAT3 pathway in mediating the protective effect of agomelatine against methotrexate-induced lung/intestinal tissues damage in rats	5
Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice	5
Tectoridin alleviates lipopolysaccharide-induced inflammation via inhibiting TLR4-NF-κB/NLRP3 signaling in vivo and in vitro	4
Effects of Trigonella foenum graecum (fenugreek) on rheumatoid arthritis: a systematic review	4
Compound glycyrrhiza oral solution alleviates oxidative stress and inflammation by regulating SRC/MAPK pathway in chronic obstructive pulmonary disease	4
Targeting the cGAS-STING pathway as an inflammatory crossroad in coronavirus disease 2019 (COVID-19)	4
T cell metabolism and possible therapeutic targets in systemic lupus erythematosus: a narrative review	4
Anlotinib attenuates experimental autoimmune encephalomyelitis mice model of multiple sclerosis via modulating the differentiation of Th17 and Treg cells	4
CCCTC-binding factor-mediated microRNA-340-5p suppression aggravates myocardial injury in rats with severe acute pancreatitis through activation of the HMGB1/TLR4 axis	4
Immunomodulatory effects ofInonotus obliquuspolysaccharide on splenic lymphocytes infected withToxoplasma gondiivia NF-κB and MAPKs pathways	4
Wogonoside preserves against ischemia/reperfusion-induced myocardial injury by suppression of apoptosis, inflammation, and fibrosis via modulating Nrf2/HO-1 pathway	4
Dexpanthenol may protect the brain against lipopolysaccharide induced neuroinflammation via anti-oxidant action and regulating CREB/BDNF signaling	4
miR-155-5p/FOXO3a promotes pulmonary fibrosis in rats by mediating NLRP3 inflammasome activation	4
The effect of omega-3 fatty acids supplementation on inflammatory biomarkers in subjects with migraine: a randomized, double-blind, placebo-controlled trial	4
Immunosuppressive activity of daphnetin on the humoral immune responses in ovalbumin-sensitized BALB/c mice	4
The potential interplay between opioid and the toll-like receptor 4 (TLR-4)	4
Promising drug repurposing approach targeted for cytokine storm implicated in SARS-CoV-2 complications	4
Etidronate down-regulates Toll-like receptor 2 ligand-induced chemokine production by inhibiting MyD88 expression and NF-κB activation	4
Sarsasapogenin and fluticasone combination improves DNFB induced atopic dermatitis lesions in BALB/c mice	4
VISTA-Ig ameliorates OXA-induced allergic dermatitis symptoms in mice	4
Combination of tetrandrine and 3-n-butylphthalide protects against cerebral ischemia-reperfusion injury via ATF2/TLR4 pathway	4
Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway	4
Insight into the dichotomous regulation of STING activation in immunotherapy	4
Extracellular vesicle-derived LINC00511 promotes glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer through macrophage polarization by microRNA-193a-3p-dependent regulation of	4
Chymotrypsin attenuates adjuvant-induced arthritis by downregulating TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6 expression in Sprague–Dawley rats	4
Pre-clinical investigation of protective effect of nutraceutical D-glucosamine on TNBS-induced colitis	4
Phloroglucinol possesses anti-inflammatory activities by regulating AMPK/Nrf2/HO-1 signaling pathway in LPS-stimulated RAW264.7 murine macrophages	4
Astragaloside IV restores Th17/Treg balance via inhibiting CXCR4 to improve chronic obstructive pulmonary disease	4
LINC00707 knockdown inhibits IL-1β-induced apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes by the miR-330-5p/FSHR axis	4
Circular RNA from phosphodiesterase 4D can attenuate chondrocyte apoptosis and matrix degradation under OA milieu induced by IL-1β via circPDE4D/miR-4306/SOX9 Cascade	4
Scutellarin alleviates lipopolysaccharide-provoked septic nephrotoxicity via attenuation of inflammatory and oxidative events and mitochondrial dysfunction	4
Capillin protects against non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation and oxidative stress	4
SRPK1 promotes sepsis-induced acute lung injury via regulating PI3K/AKT/FOXO3 signaling	4

IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance	4
Monensin synergizes with chemotherapy in uveal melanoma through suppressing RhoA	4
Tetrandrine-induced downregulation of lncRNA NEAT1 inhibits rheumatoid arthritis progression through the STAT3/miR-17-5p pathway	4
Geniposidic acid protects lipopolysaccharide-induced acute lung injury via the TLR4/MyD88 signaling pathway in vitro and in vivo	3
Fraxetin suppresses the proliferation, migration, and invasion of ovarian cancer cells by inhibiting the TLR4/STAT3 signaling pathway	3
N-acetylcysteine decreases lung inflammation and fibrosis by modulating ROS and Nrf2 in mice model exposed to particulate matter	3
Human umbilical-cord-derived mesenchymal stem cells in combination with rapamycin reduce cartilage degradation via inhibition of the AKT/mTOR signaling pathway	3
Expression of calcitonin gene-related peptide in atopic dermatitis and correlation with distress	3
α-Cyperone ameliorates depression in mammary gland hyperplasia and chronic unpredictable mild stress rat by regulating hormone, inflammation, and oxidative stress	3
Randomized double-blinded controlled trial on the effect of synbiotic supplementation on IL-17/IL-23 pathway and disease activity in patients with axial spondyloarthritis	3
Anti-psoriasis activities of hydroxytyrosol on HaCaT cells under psoriatic inflammation in vitro	3
microRNA-103a-3p promotes inflammation and fibrosis in nonalcoholic fatty liver disease by targeting HBP1	3
MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway	3
Immunosuppressive effects of dimethyl fumarate on dendritic cell maturation and migration: a potent protector for coronary heart disease	3
DNA methyltransferase inhibitors increase NOD-like receptor activity and expression in a monocytic cell line	3
The function and mechanism of microRNA-92a-3p in lipopolysaccharide-induced acute lung injury	3
IGF2BP3 aggravates lung adenocarcinoma progression by modulation of PI3K/AKT signaling pathway	3
Luteolin restored Treg/Th17 balance to ameliorate allergic rhinitis in a mouse model	3
Stevioside inhibits lipopolysaccharide-induced epithelial-to-mesenchymal transition of NRK-52E cells by PPARγ activation	3
Anti-tumor effect of M2000 (β- d -mannuronic acid) on the expression of inflammatory molecules in the prostate cancer cell	3
The effect of N -acetyl cysteine and doxycycline on TNF-α-Rel-a inflammatory pathway and downstream angiogenesis factors in the cornea of rats injured by 2-chloroethyl-e	3
Anti-inflammatory activities of a new VEGF blocker, Conbercept	3
Impact of interleukin-32α on T helper cell-related cytokines, transcription factors, and proliferation in patients with type 2 diabetes mellitus	3
TLR4/NF-κB/TNFα and cAMP/SIRT1 signaling cascade involved in mediating the dose-dependent effect of cilostazol in ovarian ischemia reperfusion-induced injury	3
Effects of sulfasalazine in axial spondyloarthritis on COVID-19 outcomes: real-life data from a single center	3
Caspase-1 inhibition by YVAD generates tregs pivoting IL-17 to IL-22 response in β-glucan induced airway inflammation	3
CIITA expression is regulated by histone deacetylase enzymes and has a role in α-synuclein pre-formed fibril-induced antigen presentation in murine microglial cell line	3
Quercetin attenuates lipopolysaccharide-mediated inflammatory injury in human nasal epithelial cellsviaregulating miR-21/DMBT1/NF-κB axis	3
Immunomodulatory effects of fentanyl and morphine on DSS- and TNBS-induced colitis	3