OOIR: Observatory of International Research

Papers

(The median citation count of Autoimmunity is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Alteration of reactive oxygen species master transcription factor Nrf2 in keratinocytes exposed to monoclonal pathogenic antibody AK23 against desmoglein-3 in pemphigus vulgaris	83
Endonuclease G promotes preeclampsia by regulating the Wnt signaling pathway	38
Antigen presentation-related protein APOL3 promotes anti-tumor T cell immunity and suppresses melanoma cell growth in mice	35
Sodium propionate improves rheumatoid arthritis by inhibiting survivin mediated proliferation of fibroblast like synoviocytes by promoting miR-140-5p	34
Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization	31
The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases	25
CAFs-released exosomal CREB1 promotes cell progression and immune evasion in thyroid cancer via the positive regulation of CCL20	23
Significance of glomerular IgG3 deposition in patients with primary membranous nephropathy	23
Characterization of IL-10-producing regulatory B cells in thymoma	23
Mitochondria as a key player in systemic lupus erythematosus	22
Subchronic intranasal lipopolysaccharide exposure induces pulmonary autoimmunity and glomerulonephritis in NZBWF1 mice	21
Increased IgD and CD27 Double Negative (DN) B cell population in pediatric onset autoimmune hepatitis	20
The cGAS-STING pathway in systemic lupus erythematosus and lupus nephritis: a review of novel therapeutic targets	18
MiR-361-5p promotes proliferation and inhibits apoptosis of fibroblast-like synoviocytes via targeting ZBTB10 in rheumatoid arthritis	17
Identified potential biomarkers may predict primary nonresponse to infliximab in patients with ulcerative colitis	17
Autoantibodies against pentraxin-3 in systemic lupus erythematosus: mapping of reactivity to linear epitopes and associations with disease variables	16
MiR-300 promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis by targeting IL-37	16
Sex-specific differences in SLE – Significance in the experimental setting of inflammation and kidney damage in MRL-Fas ^lpr mice	16
Associations between IL-23R gene polymorphism (rs10889677 A/C) and ankylosing spondylitis and rheumatoid arthritis susceptibility: A meta-analysis with trial sequential analysis	16
The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 months	16
YTHDF1 activates FBW7 transcription by regulating m ⁶ A-dependent FOXO1 to facilitate inflammatory response in ulcerative colitis-like model	16
Integrated bioinformatics reveals tubulointerstitial immune microenvironment signatures and machine learning-driven prognostication of clinical treatment response in lupus nephritis	16
Antinuclear antibody positivity in acute Epstein–Barr virus and cytomegalovirus infections	15
Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137	15
Identification and validation of susceptibility modules and hub genes in polyarticular juvenile idiopathic arthritis using WGCNA and machine learning	14

Regulation of intestinal regulatory T cells via stress response pathways in inflammatory bowel disease	14
Expression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE)	13
RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway	13
Circ_0007535 upregulates TGFBR1 to promote pulmonary fibrosis in TGF-β1-treated lung fibroblasts via sequestering miR-18a-5p	13
Molecular mechanism of Mir-27B-3P carried by bronchial epithelial cell-derived extracellular vesicle in airway inflammation in asthmatic mice	13
Effect of FcRn antagonism on protective antibodies and to vaccines in IgG-mediated autoimmune diseases pemphigus and generalised myasthenia gravis	13
Exploring the molecular mechanisms underlying the inflammation–cancer transformation in Hashimoto thyroiditis using single-cell transcriptomics	12
Identification of potential diagnostic biomarkers for systemic juvenile idiopathic arthritis by integrative transcriptomic analysis	12
Immunoenhancement activity of Bletilla striata polysaccharide through MAPK and NF-κB signalling pathways in vivo and in vitro	12
Identification of mite-specific eosinophils in the colon of patients with ulcerative colitis	12
Aberrant expression of triggering receptor expressed on myeloid cell-1 is involved in the immunopathological mechanism of myasthenia gravis	12
Lactylation-related genes serve as potential markers for the diagnosis and immune infiltration in rheumatoid arthritis	12
Identification of new hub- ferroptosis-related genes in Lupus Nephritis	12
IL-4 polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis	11
Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients	11
Identification of prognostic biomarkers of breast cancer based on the immune-related gene module	11
Deciphering distinct pathogenic mechanisms of ankylosing spondylitis and systemic sclerosis via shared biomarkers ZSWIM6 and CCL3L3: Insights from an integrative bioinformatics approach	11
Type B thymomas in patients with myasthenia gravis display a distinctive pattern of αβ TCR and IL-7 receptor α expression on CD4 ⁺ CD8 ⁺	11
Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues	11
High throughput multiplex immunoassays stratify patients according to symptom burden across the anti-Ro positive systemic autoimmune rheumatic disease spectrum	10
Roles of T cell subpopulations in thyroid eye disease	10
Identification of the immune-related diagnostic biomarkers between Graves' disease and thyroid carcinoma based on comprehensive bioinformatics analysis and machine learning	10
A novel circRNA, circRACGAP1, hampers the progression of systemic lupus erythematosus via miR-22-3p-mediated AKT signalling	10
Novel peripheral blood mononuclear cell mRNA signature for IFN-beta therapy responsiveness prediction in multiple sclerosis	10
GADD45B predicts lung squamous cell carcinoma survival and impacts immune infiltration, and T cell exhaustion	10
Circ_0114428 promotes proliferation, fibrosis and EMT process of high glucose-induced glomerular mesangial cells through regulating the miR-185-5p/SMAD3 axis	9
Identification of TXN and F5 as novel diagnostic gene biomarkers of the severe asthma based on bioinformatics and machine learning analysis	9
Correction	9
KISS-1 knockdown inhibits cell growth, migration, and invasion in HTR-8/SVneo cells by regulating the GRP54-mediated PI3K/AKT signaling pathway	9
Identifying the potential therapeutic targets of tertiary lymphoid structure in IgA nephropathy based on bioinformatics	9
GFPT1 facilitates immune escape in breast cancer by promoting the OGT-mediate O-GlcNAcylation of CD39	9
Circ_0005714/miR-223-3p/ADAM9 regulatory axis affects proliferation, migration, invasion, and angiopoiesis in trophoblast cells	9
Serum sirtuin-1 a potential marker in the diagnosis of rheumatoid arthritis	9
Exploring the key functions of T cells and the regulation of the immune microenvironment in prostate cancer using single-cell RNA sequencing and bulk RNA sequencing	9
IDO1-mediated M2 macrophage polarization alleviates the progression of ankylosing spondylitis	9
The trilateral nexus of autoimmune thyroiditis: integrating immunological triggers, endocrine disruption, and gut microbiome alterations for treatment strategies	8
The role of gut microbiota in different murine models of systemic lupus erythematosus	8
Quantification of residual plasmid DNA and SV40 promoter-enhancer sequences in Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada	8
Single-cell transcriptomic analysis reveals T cell heterogeneity and metabolic reprogramming in human immune-mediated glomerulonephritis	8
Knockdown of NEK7 alleviates anterior cruciate ligament transection osteoarthritis (ACLT)-induced knee osteoarthritis in mice via inhibiting NLRP3 activation	8
The role of IRF-1 in mediating T-cell immune imbalance in systemic lupus erythematosus and the construction of a diagnostic model	8
CircCDK14 ameliorates interleukin-1β-induced chondrocyte damage by the miR-1183/KLF5 pathway in osteoarthritis	8
Genome-wide identification of cell type-specific susceptibility genes for Juvenile dermatomyositis through the analysis of N ⁶ -methyladenosine-associated SNPs	8
Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis	8
A whole blood-based functional assay to characterize immunoglobulin A effector functions	7
CircNRIP1 promotes proliferation, migration and phenotypic switch of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA stability via recruiting IGF2BP1	7
Exploring the mechanism of autophagy and inflammation in osteoarthritis through bioinformatics and experimental verification	7
Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pa	7
Circulating interleukin-27 is associated with the risk of chronic periodontitis and allergic rhinitis: A Mendelian randomization analysis	7
Unveiling causal pathways in autoimmune diseases: a multi-omics approach	7

OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis	7
Functional significance of the rare rs35667974 IFIH1 gene polymorphism, associated with multiple autoimmune diseases, using a structural biological approach	7
The shared mechanisms and potential diagnostic markers for IgA nephropathy and celiac disease	7
Immunogenic self-DNA drives neuropsychiatric systemic lupus erythematosus in conventional genetic background mice	7
Isorhynchophylline attenuates proliferation and migration of synovial fibroblasts via the FOXC1/β-catenin axis	7
Progress in the field of animal models of antiphospholipid syndrome	6
LncRNA LINC00707 serves as a sponge of miR-382-5p to alleviate lipopolysaccharide (LPS)-induced WI-38 cell injury through upregulating NKAP in infantile pneumonia	6
Potential significance of changes in serum levels of IL-17, TNF-α and DKK-1 in the progression of the rheumatoid arthritis	6
HERC6 is upregulated in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and promotes the disease progression	6
Astragaloside IV promotes the pyroptosis of airway smooth muscle cells in childhood asthma by suppressing HMGB1/RAGE axis to inactivate NF-κb pathway	6
Effects of Apelin on the fibrosis of retinal tissues and Müller cells in diabetes retinopathy through the JAK2/STAT3 signalling pathway	6
CA72-4 derived from synovial cells inhibits monosodium urate-induced macrophage M1 polarization by activating the TIGIT/SHP-1 axis through binding to Siglec-15	6
Correction	5
LncRNA HOTAIR inhibits the progression of fibroblast-like synoviocytes by sponging miRNA-106b-5p in rheumatoid arthritis	5
Patients with dermatomyositis shared partially similar transcriptome signature with COVID-19 infection	5
Mesenchymal stem cells-derived exosomes ameliorate high glucose and lipopolysaccharide-induced HPMECs injury through the Nrf2/HO-1 pathway	5
Analysis of circulating immune cells in patients with rheumatoid arthritis and positive for hashimoto thyroiditis antibodies	5
Mitochondrial autophagy-related gene signatures associated with myasthenia gravis diagnosis and immunity	5
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus	5
High-throughput autoantibody profiling of different stages of Schistosomiasis japonica	5
Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis	5
LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via regulating the Wnt/β-catenin pathway	5
LDHA-induced histone lactylation mediates the development of osteoarthritis through regulating the transcription activity of TPI1 gene	5
Regulatory role of ceRNA network in B lymphocytes of patients with immune thrombocytopenia	4
Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2	4
Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression	4
Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis	4
Identification of macrophage-related molecular subgroups and risk signature in colorectal cancer based on a bioinformatics analysis	4
Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in Crohn’s disease by integrating bioinformatics and machine learning	4
Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes chondrogenesis in osteoarthritis	4
Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on renal injury in systemic lupus erythematosus	4
DNA polymerase ζ suppresses the radiosensitivity of glioma cells by regulating the PI3K/AKT/mTOR pathway	4
Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells	4
Research progress in the construction of animal models of autoimmune thyroiditis	4
MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy	4
SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis	4
Paeoniflorin improves autoimmune myocarditis in young rat by inhibiting CXCR5 to reduce follicular helper T cells	4
SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19	4
Exosomal circ_001895 from lung cancer cells drives M2 macrophage polarization via the miR-20a-5p/JAK1/STAT3 axis to promote tumor progression	4