OOIR: Observatory of International Research

Papers

(The median citation count of Autoimmunity is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Alteration of reactive oxygen species master transcription factor Nrf2 in keratinocytes exposed to monoclonal pathogenic antibody AK23 against desmoglein-3 in pemphigus vulgaris	85
Endonuclease G promotes preeclampsia by regulating the Wnt signaling pathway	39
Antigen presentation-related protein APOL3 promotes anti-tumor T cell immunity and suppresses melanoma cell growth in mice	38
Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization	36
CAFs-released exosomal CREB1 promotes cell progression and immune evasion in thyroid cancer via the positive regulation of CCL20	32
The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases	28
Characterization of IL-10-producing regulatory B cells in thymoma	26
Subchronic intranasal lipopolysaccharide exposure induces pulmonary autoimmunity and glomerulonephritis in NZBWF1 mice	23
Significance of glomerular IgG3 deposition in patients with primary membranous nephropathy	23
Increased IgD and CD27 Double Negative (DN) B cell population in pediatric onset autoimmune hepatitis	23
Mitochondria as a key player in systemic lupus erythematosus	21
The cGAS-STING pathway in systemic lupus erythematosus and lupus nephritis: a review of novel therapeutic targets	20
Integrated bioinformatics reveals tubulointerstitial immune microenvironment signatures and machine learning-driven prognostication of clinical treatment response in lupus nephritis	20
Identified potential biomarkers may predict primary nonresponse to infliximab in patients with ulcerative colitis	17
Sex-specific differences in SLE – Significance in the experimental setting of inflammation and kidney damage in MRL-Fas ^lpr mice	17
MiR-300 promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis by targeting IL-37	17
Antinuclear antibody positivity in acute Epstein–Barr virus and cytomegalovirus infections	16
Monocyte exhaustion associated with systemic lupus erythematosus	16
The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24–59 months	16
Autoantibodies against pentraxin-3 in systemic lupus erythematosus: mapping of reactivity to linear epitopes and associations with disease variables	16
Identification and validation of susceptibility modules and hub genes in polyarticular juvenile idiopathic arthritis using WGCNA and machine learning	16
YTHDF1 activates FBW7 transcription by regulating m ⁶ A-dependent FOXO1 to facilitate inflammatory response in ulcerative colitis-like model	16
Regulation of intestinal regulatory T cells via stress response pathways in inflammatory bowel disease	15
Molecular mechanism of Mir-27B-3P carried by bronchial epithelial cell-derived extracellular vesicle in airway inflammation in asthmatic mice	15
Circ_0007535 upregulates TGFBR1 to promote pulmonary fibrosis in TGF-β1-treated lung fibroblasts via sequestering miR-18a-5p	15

Expression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE)	15
Aberrant expression of triggering receptor expressed on myeloid cell-1 is involved in the immunopathological mechanism of myasthenia gravis	14
Inhibition of LncRNA SNHG14 protects chondrocyte from injury in osteoarthritis via sponging miR-137	14
Exploring the molecular mechanisms underlying the inflammation–cancer transformation in Hashimoto thyroiditis using single-cell transcriptomics	13
Identification of potential diagnostic biomarkers for systemic juvenile idiopathic arthritis by integrative transcriptomic analysis	13
Identification of mite-specific eosinophils in the colon of patients with ulcerative colitis	13
Lactylation-related genes serve as potential markers for the diagnosis and immune infiltration in rheumatoid arthritis	13
Identification of new hub- ferroptosis-related genes in Lupus Nephritis	13
RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway	12
Type B thymomas in patients with myasthenia gravis display a distinctive pattern of αβ TCR and IL-7 receptor α expression on CD4 ⁺ CD8 ⁺	12
Effect of FcRn antagonism on protective antibodies and to vaccines in IgG-mediated autoimmune diseases pemphigus and generalised myasthenia gravis	12
IL-4 polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis	12
Immunoenhancement activity of Bletilla striata polysaccharide through MAPK and NF-κB signalling pathways in vivo and in vitro	11
KISS-1 knockdown inhibits cell growth, migration, and invasion in HTR-8/SVneo cells by regulating the GRP54-mediated PI3K/AKT signaling pathway	11
Deciphering distinct pathogenic mechanisms of ankylosing spondylitis and systemic sclerosis via shared biomarkers ZSWIM6 and CCL3L3: Insights from an integrative bioinformatics approach	11
Identification of prognostic biomarkers of breast cancer based on the immune-related gene module	11
Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients	11
Roles of T cell subpopulations in thyroid eye disease	11
Identification of the immune-related diagnostic biomarkers between Graves' disease and thyroid carcinoma based on comprehensive bioinformatics analysis and machine learning	10
High throughput multiplex immunoassays stratify patients according to symptom burden across the anti-Ro positive systemic autoimmune rheumatic disease spectrum	10
Circ_0114428 promotes proliferation, fibrosis and EMT process of high glucose-induced glomerular mesangial cells through regulating the miR-185-5p/SMAD3 axis	10
GADD45B predicts lung squamous cell carcinoma survival and impacts immune infiltration, and T cell exhaustion	10
Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues	10
Novel peripheral blood mononuclear cell mRNA signature for IFN-beta therapy responsiveness prediction in multiple sclerosis	10
Circ_0005714/miR-223-3p/ADAM9 regulatory axis affects proliferation, migration, invasion, and angiopoiesis in trophoblast cells	9
Genome-wide identification of cell type-specific susceptibility genes for Juvenile dermatomyositis through the analysis of N ⁶ -methyladenosine-associated SNPs	9
Serum sirtuin-1 a potential marker in the diagnosis of rheumatoid arthritis	9
Single-cell transcriptomic analysis reveals T cell heterogeneity and metabolic reprogramming in human immune-mediated glomerulonephritis	9
Identification of TXN and F5 as novel diagnostic gene biomarkers of the severe asthma based on bioinformatics and machine learning analysis	9
IDO1-mediated M2 macrophage polarization alleviates the progression of ankylosing spondylitis	9
Correction	9
Identifying the potential therapeutic targets of tertiary lymphoid structure in IgA nephropathy based on bioinformatics	9
CircCDK14 ameliorates interleukin-1β-induced chondrocyte damage by the miR-1183/KLF5 pathway in osteoarthritis	8
IgA Vasculitis with necrotizing arteritis: a multicenter retrospective study from the French Vasculitis Study Group and systematic review of the literature	8
Quantification of residual plasmid DNA and SV40 promoter-enhancer sequences in Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada	8
Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis	8
The trilateral nexus of autoimmune thyroiditis: integrating immunological triggers, endocrine disruption, and gut microbiome alterations for treatment strategies	8
The role of IRF-1 in mediating T-cell immune imbalance in systemic lupus erythematosus and the construction of a diagnostic model	8
Global research trends in ferroptosis in autoimmune diseases: a bibliometric and visual analysis (2018−2025)	8
Exploring the key functions of T cells and the regulation of the immune microenvironment in prostate cancer using single-cell RNA sequencing and bulk RNA sequencing	8
Knockdown of NEK7 alleviates anterior cruciate ligament transection osteoarthritis (ACLT)-induced knee osteoarthritis in mice via inhibiting NLRP3 activation	8
GFPT1 facilitates immune escape in breast cancer by promoting the OGT-mediate O-GlcNAcylation of CD39	8
The role of gut microbiota in different murine models of systemic lupus erythematosus	7
OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis	7
Isorhynchophylline attenuates proliferation and migration of synovial fibroblasts via the FOXC1/β-catenin axis	7
CircNRIP1 promotes proliferation, migration and phenotypic switch of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA stability via recruiting IGF2BP1	7
Functional significance of the rare rs35667974 IFIH1 gene polymorphism, associated with multiple autoimmune diseases, using a structural biological approach	7
Circulating interleukin-27 is associated with the risk of chronic periodontitis and allergic rhinitis: A Mendelian randomization analysis	7
The shared mechanisms and potential diagnostic markers for IgA nephropathy and celiac disease	7
Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pa	7

A whole blood-based functional assay to characterize immunoglobulin A effector functions	7
Exploring the mechanism of autophagy and inflammation in osteoarthritis through bioinformatics and experimental verification	6
Immunogenic self-DNA drives neuropsychiatric systemic lupus erythematosus in conventional genetic background mice	6
Unveiling causal pathways in autoimmune diseases: a multi-omics approach	6
Progress in the field of animal models of antiphospholipid syndrome	6
HERC6 is upregulated in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and promotes the disease progression	6
Effects of Apelin on the fibrosis of retinal tissues and Müller cells in diabetes retinopathy through the JAK2/STAT3 signalling pathway	6
LDHA-induced histone lactylation mediates the development of osteoarthritis through regulating the transcription activity of TPI1 gene	5
Astragaloside IV promotes the pyroptosis of airway smooth muscle cells in childhood asthma by suppressing HMGB1/RAGE axis to inactivate NF-κb pathway	5
Mitochondrial autophagy-related gene signatures associated with myasthenia gravis diagnosis and immunity	5
LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via regulating the Wnt/β-catenin pathway	5
Patients with dermatomyositis shared partially similar transcriptome signature with COVID-19 infection	5
CA72-4 derived from synovial cells inhibits monosodium urate-induced macrophage M1 polarization by activating the TIGIT/SHP-1 axis through binding to Siglec-15	5
High-throughput autoantibody profiling of different stages of Schistosomiasis japonica	5
Analysis of circulating immune cells in patients with rheumatoid arthritis and positive for hashimoto thyroiditis antibodies	5
Mesenchymal stem cells-derived exosomes ameliorate high glucose and lipopolysaccharide-induced HPMECs injury through the Nrf2/HO-1 pathway	5
LncRNA HOTAIR inhibits the progression of fibroblast-like synoviocytes by sponging miRNA-106b-5p in rheumatoid arthritis	5
Potential significance of changes in serum levels of IL-17, TNF-α and DKK-1 in the progression of the rheumatoid arthritis	5
Correction	5
Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis	5
Research progress in the construction of animal models of autoimmune thyroiditis	4
Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2	4
Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells	4
Paeoniflorin improves autoimmune myocarditis in young rat by inhibiting CXCR5 to reduce follicular helper T cells	4
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus	4
Exosomal circ_001895 from lung cancer cells drives M2 macrophage polarization via the miR-20a-5p/JAK1/STAT3 axis to promote tumor progression	4
Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes chondrogenesis in osteoarthritis	4
Regulatory role of ceRNA network in B lymphocytes of patients with immune thrombocytopenia	4
MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy	4
SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis	4
Identification of macrophage-related molecular subgroups and risk signature in colorectal cancer based on a bioinformatics analysis	4
Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on renal injury in systemic lupus erythematosus	4
Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in Crohn’s disease by integrating bioinformatics and machine learning	4