OOIR: Observatory of International Research

Papers

(The H4-Index of Free Radical Biology and Medicine is 60. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Human 3D full skin models coupled with advanced bio-markers assessment for the efficacy evaluation of topical redox modulators	455
The use of systems biology in treatment of metabolic diseases	259
Peroxiporins: can they modulate cancer resistance?	195
The Relationship between Mitochondrial Oxidative Stress and Huntington’s Disease Progression	194
Oxidative damage in reperfusion after stroke: ferroptosis and the role of the mitochondrial sodium/calcium exchanger NCLX	192
Oxysterols in the development of diabetes and cardiovascular diseases	189
Editorial Board	188
Allogeneic platelet-rich plasma inhibits ferroptosis in promoting wound repair of type 2 diabetic ulcers	169
Enduring metabolic modulation in the cardiac tissue of elderly CD-1 mice two months post mitoxantrone treatment	160
Corrigendum to “Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage” [Free Radic. Biol. Med. 208 (2023) 555–570]	144
Mitochondrial redox state, bioenergetics, and calcium transport in caloric restriction: A metabolic nexus	141
Selective inhibition of GSK3? mediates an Nrf2-independent anti-inflammatory microglial response	140
Hydrogen peroxide diffusion across human red blood cell membranes is not facilitated by aquaporins	132
Impaired Metabolic and Inflammatory Responses in a Murine Model of Leigh Syndrome	130
Arachidonic acid-derived lipoxin A4 yields an electrophilic 15-oxo metabolite that induces anti-inflammatory responses independent of FPR2 receptor signaling	129
Site-Specific Tyrosine Nitration of Heat Shock Protein 90 Plays Distinct Roles in Glioblastoma Multiforme	126
Antiproliferative Effect of Novel Phenolic Antioxidant TS-13 in vitro	116
The stability and degradation products of polyhydroxy flavonols in boiling water	113
Heme nitrosyl complexes: insights into protein/protein transfer and cell trafficking	104
Shielding of Phospholipid Oxidation by 5,7-unsaturated Sterol Metabolites	102
Endothelial cells derived from elephant seals respond to extended hypoxia by suppressing inflammation and conserving glutathione	97
Characterization of human mitochondrial aconitase and its interaction with frataxin	94
7-Dehydrocholesterol protects membrane phospholipids from oxidation	93
Adjunctive effects with continual X-ray irradiation for effective photodynamic therapy	93
Synthesis and Applications of Metal Organic Frameworks in Photodynamic Therapy	92

Extracellular Superoxide Dismutase Regulation of Metabolism and Oxidative Stress in Pulmonary Artery Smooth Muscle Cells	88
Regulation of ERK1/2 Phosphorylation, Oxidation, and Cell Cycle Progression by Miro1 Mediated Mitochondrial Positioning	86
Liposomal Encapsulation Augments Kaempferol-induced Apoptosis in Glioblastoma cells via a Pro-oxidation Pathway	84
Radiation-induced Glioblastoma Extracellular Vesicles Containing 4HNE Promote Microglia-Mediated Neurotoxicity	84
Oxidative Stress Is Higher In Women With Sarcopenic Obesity	83
Mouse models used to test the role of reactive oxygen species in aging and age-related chronic diseases	83
A Role for NRF2 in the Lung Epithelial Cell Response to Wood Smoke	83
CIRBP regulates mitochondrial respiratory function and modulates neuronal developmental abnormalities induced by perinatal hypoxia	81
Hinokitiol modulates Nrf2/HO-1 signaling, autophagy, and URAT1 in hyperuricemia and oxidative stress models of renal injury	81
Epigenetic and “redoxogenetic” adaptation to physical exercise	79
Effect of melatonin on oxidative stress indicators in animal models of fibrosis: A systematic review and meta-analysis	76
Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through GAPDH- and Hsp90-dependent control of their heme levels	75
Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway	74
Coenzyme Q10 and nicotinamide nucleotide transhydrogenase: Sentinels for mitochondrial hydrogen peroxide signaling	73
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis	73
Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency	72
Assembly of mitochondrial succinate dehydrogenase in human health and disease	72
Erianin inhibits the growth and metastasis through autophagy-dependent ferroptosis in KRASG13D colorectal cancer	72
Interferon-γ induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK/STAT1-mediated inhibition of system Xc-	71
A neutralizing antibody and a p75NTR inhibitor prevent neuronal apoptosis induced by oxidatively modified NGF	70
Effect OF m-trifluoromethyl- attachment on the glutathione peroxidase mimicry and antioxidant actions of diphenyl diselenide: Essential thiols of electrogenic sodium pump as a mechanistic componen	67
PIDD1 and p90RSK Mediate Radiation-Induced Genomic Instability in Endothelial Cells: Implications for Cardiovascular Disease Prevention	67
Extracellular Superoxide Dismutase R213G Variant Protects Against Lung Fibrosis by Activating AMPK and Limiting Lipid Accumulation	67
Antioxidants Fail to Prevent Glucose Hypometabolism-Induced Neural Cell Death, Unlike Dimethyl-2-oxoglutarate: Implications in Alzheimer’s Disease	66
Breath Biomarkers for Monitoring In Vivo Redox Metabolism	65
Investigation of Nrf2-Keap-1 and Sestrin-2 Pathways in Hidradenitis Suppurativa Patient Sera	63
The nitrone compound LQB122 improves adipogenesis and reduces obesity-associated metabolic risk	63
Cu Transport Proteins as Novel Therapeutic Targets for Cu-dependent Brain Endothelial Barrier Dysfunction and Cuproptosis linked to Alzheimer’s Disease	63
Exploring the non-toxic therapeutic potential of dioscorea communis in combating oral pathogenic bacteria and their effect on hard and soft oral tissues	61
Lipid-derived electrophiles induce carbonyl stress, mitochondrial dysfunction, and cellular senescence: 4-hydroxynonenal as a physiological determinant of adipose senescence in obesity and aging	61
Hepatic IκBζ promotes alcohol-associated liver disease and acute hepatitis by enhancing CXCL1-Mediated neutrophil infiltration	61
Characterization of immunogenic MDA-lipidperoxidation epitopes on human plasma extracellular vesicles recognized by a human monoclonal IGM-antibody	61
Therapeutic potential of plasma-treated solutions in atopic dermatitis	61
Fluorescence imaging for the progression of oxidative stress-related diseases	60
A comprehensive LC-MS/MS approach for the monitoring of oxidative stress markers in gingival samples	60
GSNOR drives age-related obesity by regulating the S-nitrosation of Beclin-1 to promote adipose tissue whitening	60
Short-term blockade of E-prostanoid 3 receptor curbs necroinflammation and protects against I/R- and doxorubicin-induced acute myocardial injury	60