OOIR: Observatory of International Research

Papers

(The H4-Index of Free Radical Biology and Medicine is 61. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Lipid peroxidation and ferroptosis: The role of GSH and GPx4	731
Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease	568
Air pollution and its effects on the immune system	322
Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury	303
Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell	227
Ascorbic acid: The chemistry underlying its antioxidant properties	223
Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy	190
Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives	159
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion	146
Beyond repression of Nrf2: An update on Keap1	143
Resveratrol reduces obesity in high-fat diet-fed mice via modulating the composition and metabolic function of the gut microbiota	134
Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections	128
Oxidative stress and the cardiovascular effects of air pollution	123
Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis	112
Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19	110
Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease	105
Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases	104
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway	100
Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs–NF–κB signaling pathway and pyroptosis after secondary spinal cord injury	99
The emerging potential of cold atmospheric plasma in skin biology	99
Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4	99
Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells	98
Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies	95
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling	95
Exosomes from adipose-derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2/HO-1 axis in macrophages	94

Ambient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management	91
AGE/RAGE in diabetic kidney disease and ageing kidney	89
Green tea derivative (−)-epigallocatechin-3-gallate (EGCG) confers protection against ionizing radiation-induced intestinal epithelial cell death both in vitro and in vivo	89
Targeting SLC3A2 subunit of system XC− is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma	87
Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis	85
The role of glutathione redox imbalance in autism spectrum disorder: A review	84
Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse	81
Antioxidant properties of anthocyanins and their mechanism of action in atherosclerosis	81
The role of NO in COVID-19 and potential therapeutic strategies	81
Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway	78
Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury	76
Reactivity and degradation products of tryptophan in solution and proteins	75
Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications	75
Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage	74
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy	74
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects	73
Browsing the oldest antioxidant enzyme: catalase and its multiple regulation in cancer	72
Cold plasma seed priming modulates growth, redox homeostasis and stress response by inducing reactive species in tomato (Solanum lycopersicum)	71
Transcription factor NRF2 as a promising therapeutic target for Alzheimer’s disease	71
Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury	70
Butyrate alleviates oxidative stress by regulating NRF2 nuclear accumulation and H3K9/14 acetylation via GPR109A in bovine mammary epithelial cells and mammary glands	68
The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases	67
Nitrate ameliorates dextran sodium sulfate-induced colitis by regulating the homeostasis of the intestinal microbiota	67
PINK1-mediated mitophagy protects against hepatic ischemia/reperfusion injury by restraining NLRP3 inflammasome activation	65
The glutathione peroxidase family: Discoveries and mechanism	64
Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and autophagy	63
Molecular mechanisms underlying health benefits of tea compounds	63
Mitochondrial dysfunction promotes aquaporin expression that controls hydrogen peroxide permeability and ferroptosis	63
Impact of air pollution on intestinal redox lipidome and microbiome	63
Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress	63
Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells	63
Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets	62
Drp1-regulated PARK2-dependent mitophagy protects against renal fibrosis in unilateral ureteral obstruction	62
Mitochondrial unfolded protein response: An emerging pathway in human diseases	61
The role of glutathione peroxidase-1 in health and disease	61
Vitamin E alpha- and gamma-tocopherol mitigate colitis, protect intestinal barrier function and modulate the gut microbiota in mice	61