OOIR: Observatory of International Research

Papers

(The H4-Index of Free Radical Biology and Medicine is 61. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury	371
Ascorbic acid: The chemistry underlying its antioxidant properties	281
Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell	280
Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy	235
Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives	214
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion	169
Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis	136
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway	136
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling	133
Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases	129
Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells	122
Exosomes from adipose-derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2/HO-1 axis in macrophages	121
Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs–NF–κB signaling pathway and pyroptosis after secondary spinal cord injury	115
Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4	112
AGE/RAGE in diabetic kidney disease and ageing kidney	110
The emerging potential of cold atmospheric plasma in skin biology	109
Targeting SLC3A2 subunit of system XC− is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma	109
Green tea derivative (−)-epigallocatechin-3-gallate (EGCG) confers protection against ionizing radiation-induced intestinal epithelial cell death both in vitro and in vivo	106
Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis	105
Antioxidant properties of anthocyanins and their mechanism of action in atherosclerosis	105
Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury	103
The role of glutathione redox imbalance in autism spectrum disorder: A review	102
Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse	98
The role of glutathione peroxidase-1 in health and disease	95
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy	94

Reactivity and degradation products of tryptophan in solution and proteins	94
Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury	93
Browsing the oldest antioxidant enzyme: catalase and its multiple regulation in cancer	92
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects	91
Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage	90
The glutathione peroxidase family: Discoveries and mechanism	88
Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications	85
Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis	85
The role of NO in COVID-19 and potential therapeutic strategies	85
Transcription factor NRF2 as a promising therapeutic target for Alzheimer’s disease	82
Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress	79
Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells	78
Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets	78
DNA damage and oxidant stress activate p53 through differential upstream signaling pathways	78
Mitochondrial dysfunction promotes aquaporin expression that controls hydrogen peroxide permeability and ferroptosis	76
Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and autophagy	75
The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease	75
Molecular mechanisms underlying health benefits of tea compounds	74
NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2/Gpx4 pathway	73
Mitochondrial unfolded protein response: An emerging pathway in human diseases	73
Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress	73
Vitamin E alpha- and gamma-tocopherol mitigate colitis, protect intestinal barrier function and modulate the gut microbiota in mice	72
mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder	72
The dark side of gamma-glutamyltransferase (GGT): Pathogenic effects of an ‘antioxidant’ enzyme	71
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis	71
Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4	69
Beneficial effects of dietary supplementation with olive oil, oleic acid, or hydroxytyrosol in metabolic syndrome: Systematic review and meta-analysis	69
Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis	69
PINK1-mediated mitophagy protects against hepatic ischemia/reperfusion injury by restraining NLRP3 inflammasome activation	69
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes	68
Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart	68
A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury	66
Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond	65
Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis	63
Hypoxic preconditioning combined with curcumin promotes cell survival and mitochondrial quality of bone marrow mesenchymal stem cells, and accelerates cutaneous wound healing via PGC-1α/SIRT3/HIF-1α s	63
AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury	63
Oxidative stress and regeneration	61