OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
A nonneural miRNA cluster mediates hearing via repression of two neural targets	176
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	131
NDF is a transcription factor that stimulates elongation by RNA polymerase II	126
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	100
Timing is everything: transcription bursting in development	74
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	72
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	66
ALL-tRNAseq enables robust tRNA profiling in tissue samples	51
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	51
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	48
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	47
How do genomes encode developmental time?	47
Oct4 redox sensitivity potentiates reprogramming and differentiation	46
The evolving tale of Pol2 function	46
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	45
Metabolic partitioning in the brain and its hijacking by glioblastoma	44
Notch induces transcription by stimulating release of paused RNA polymerase II	44
Cohesin in 3D: development, differentiation, and disease	44
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	43
CDK4loss-of-function mutations cause microcephaly and short stature	40
Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors	39
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	39
Letters to the Editor	38
The evolution of metazoan shelterin	38
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer	37

Histone bivalency regulates the timing of cerebellar granule cell development	37
A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate	36
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	35
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	34
Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies	34
Corrigendum: Identification of a PTEN-regulated STAT₃brain tumor suppressor pathway	33
Opening the window for endothelial-to-hematopoietic transition	33
LINE-1, the NORth star of nucleolar organization	33
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	32
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	32
TBX2 controls a proproliferative gene expression program in melanoma	32
Tolerance thresholds underlie responses to DNA damage during germline development	32
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	31
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	31
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	29
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	29
Cancer neuroscience at the brain–body interface	29
How Terri Grodzicker transformedGenes & Development	29
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	28
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	27
Mitochondria dysfunction: cause or consequence of physiologic aging?	27
BMAL1 drives muscle repair through control of hypoxic NAD⁺ regeneration in satellite cells	26
Reflections on Terri	26
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	26
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	24
Multiomics analysis of the NAD⁺–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	24
Traveling with Terri: bacterial communities	24
NEAT1 promotes genome stability via m⁶A methylation-dependent regulation of CHD4	23
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	23
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	23
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	23
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	22
End of the line: a kinetic ruler model for poly(A) tail termination	22
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	21
TG andG&D: some thoughts and reminiscences	20
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation	20
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	20
An Editor's rave review	20
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	19
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	19
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	19
H3K4me3 amplifies transcription at intergenic active regulatory elements	19
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	18
Therapeutic targeting of RNA for neurological and neuromuscular disease	18
Transcription factors specifically control change	18
Introduction: 35 years on	18
A germline PAF1 paralog complex ensures cell type-specific gene expression	18
From fat to fear: how lipid powers cancer spread	17
The area postrema: a critical mediator of brain–body interactions	17
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	17

IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	17
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	17
Guide RNA acrobatics: the one-for-two shuffle	16
Spore germination: Two ion channels are better than one	16
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	16
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	16
Circadian de(regulation) in physiology: implications for disease and treatment	16
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	16
SPOC domain proteins in health and disease	16
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	15
Genetic cold cases: lessons from solving complex congenital limb disorders	15
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	14
Aging is growing up: celebrating the latest research in aging and senescence biology	14
Bridging brain and body in cancer	14
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	14
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	14
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	14
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	14
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	14
The inner workings of replisome-dependent control of DNA damage tolerance	14
The lncRNAMalat1is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	14