OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
NDF is a transcription factor that stimulates elongation by RNA polymerase II	185
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	139
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	129
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	108
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	78
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	76
A nonneural miRNA cluster mediates hearing via repression of two neural targets	71
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	60
Timing is everything: transcription bursting in development	56
ALL-tRNAseq enables robust tRNA profiling in tissue samples	51
CDK4loss-of-function mutations cause microcephaly and short stature	50
Notch induces transcription by stimulating release of paused RNA polymerase II	49
The evolving tale of Pol2 function	48
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	48
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	46
How do genomes encode developmental time?	46
Oct4 redox sensitivity potentiates reprogramming and differentiation	44
Metabolic partitioning in the brain and its hijacking by glioblastoma	44
Cohesin in 3D: development, differentiation, and disease	41
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3	41
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	40
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	39
Letters to the Editor	39
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	39
A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate	38

Histone bivalency regulates the timing of cerebellar granule cell development	38
Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors	37
The evolution of metazoan shelterin	36
Corrigendum: Identification of a PTEN-regulated STAT₃brain tumor suppressor pathway	35
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	35
Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies	35
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	34
Tolerance thresholds underlie responses to DNA damage during germline development	34
Opening the window for endothelial-to-hematopoietic transition	34
LINE-1, the NORth star of nucleolar organization	34
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	34
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	33
TBX2 controls a proproliferative gene expression program in melanoma	32
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	31
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	30
Cancer neuroscience at the brain–body interface	28
How Terri Grodzicker transformedGenes & Development	28
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	27
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	26
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	26
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	25
Mitochondria dysfunction: cause or consequence of physiologic aging?	25
BMAL1 drives muscle repair through control of hypoxic NAD⁺ regeneration in satellite cells	24
Reflections on Terri	22
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	22
Traveling with Terri: bacterial communities	22
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	21
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	21
End of the line: a kinetic ruler model for poly(A) tail termination	21
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	21
Corrigendum: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells	20
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	20
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates	20
NEAT1 promotes genome stability via m⁶A methylation-dependent regulation of CHD4	20
Multiomics analysis of the NAD⁺–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	20
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	19
TG andG&D: some thoughts and reminiscences	19
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	19
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	18
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	18
H3K4me3 amplifies transcription at intergenic active regulatory elements	18
An Editor's rave review	18
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	17
A germline PAF1 paralog complex ensures cell type-specific gene expression	17
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	17
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations	17
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	17
Introduction: 35 years on	17
Transcription factors specifically control change	17
Therapeutic targeting of RNA for neurological and neuromuscular disease	17

Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex	16
Circadian de(regulation) in physiology: implications for disease and treatment	16
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	16
Rewiring gene circuits to dissect oscillatory signaling dynamics	16
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	16
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	15
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	15
Spore germination: Two ion channels are better than one	15
From fat to fear: how lipid powers cancer spread	15
The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons	15
The area postrema: a critical mediator of brain–body interactions	15
Transcription quality control at the promoter-proximal checkpoint	15
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	15
Guide RNA acrobatics: the one-for-two shuffle	14
The inner workings of replisome-dependent control of DNA damage tolerance	14
Aging is growing up: celebrating the latest research in aging and senescence biology	14
SPOC domain proteins in health and disease	14
Bridging brain and body in cancer	14
Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	14
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	14
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	14
Genetic cold cases: lessons from solving complex congenital limb disorders	14