OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	133
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	101
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	92
A nonneural miRNA cluster mediates hearing via repression of two neural targets	90
ALL-tRNAseq enables robust tRNA profiling in tissue samples	61
Corrigendum: Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38	61
Timing is everything: transcription bursting in development	58
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	53
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	49
Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion	48
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	48
Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state	41
The evolving tale of Pol2 function	40
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	40
Metabolic partitioning in the brain and its hijacking by glioblastoma	40
Notch induces transcription by stimulating release of paused RNA polymerase II	39
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3	38
Oct4 redox sensitivity potentiates reprogramming and differentiation	35
How do genomes encode developmental time?	35
CDK4loss-of-function mutations cause microcephaly and short stature	34
Cohesin in 3D: development, differentiation, and disease	34
A lncRNA drives developmentally timed decay of all members of an essential microRNA family	34
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	34
Lights up on the embryonic dance: tools and applications of optogenetics in developmental biology	32
Letters to the Editor	31

USP7 substrates identified by proteomics analysis reveal the specificity of USP7	31
A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fat	28
Corrigendum: Identification of a PTEN-regulated STAT₃brain tumor suppressor pathway	27
Histone bivalency regulates the timing of cerebellar granule cell development	27
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	27
LINE-1, the NORth star of nucleolar organization	27
Tolerance thresholds underlie responses to DNA damage during germline development	26
The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity	26
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	25
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	25
Mutant p53: evolving perspectives	25
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	24
How Terri Grodzicker transformedGenes & Development	24
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	23
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	23
Cancer neuroscience at the brain–body interface	23
Mitochondria dysfunction: cause or consequence of physiologic aging?	22
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	22
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	22
A brain-specific microRNA, miR-1000 , regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster	22
Independent control of neurogenesis and dorsoventral patterning by NKX2-2	22
Rethinking HNF1A-MODY: HNF1A at the crossroads of development and multiorgan metabolic disease	22
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	22
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	21
Traveling with Terri: bacterial communities	21
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	21
End of the line: a kinetic ruler model for poly(A) tail termination	21
Corrigendum: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells	21
Reflections on Terri	21
Multiomics analysis of the NAD⁺–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	20
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates	20
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	20
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	20
Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer	20
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	20
An Editor's rave review	19
NEAT1 promotes genome stability via m ⁶ A methylation-dependent regulation of CHD4	19
TG andG&D: some thoughts and reminiscences	19
Multiomic analysis of clonal development reveals new regulators of leukemic cell growth	19
H3K4me3 amplifies transcription at intergenic active regulatory elements	18
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	18
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	18
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	18
A germline PAF1 paralog complex ensures cell type-specific gene expression	18
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations	17
Transcription factors specifically control change	17
Introduction: 35 years on	16
Circadian de(regulation) in physiology: implications for disease and treatment	16
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	16
Spore germination: Two ion channels are better than one	16

IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	16
SPOC domain proteins in health and disease	15
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	15
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	15
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	14
The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons	14
Rewiring gene circuits to dissect oscillatory signaling dynamics	14
The area postrema: a critical mediator of brain–body interactions	14
Transcription quality control at the promoter-proximal checkpoint	14
Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex	14
From fat to fear: how lipid powers cancer spread	14
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	14
Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	13
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	13
Bridging brain and body in cancer	13
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	13
Genetic cold cases: lessons from solving complex congenital limb disorders	13
Therapeutic targeting of RNA for neurological and neuromuscular disease	13
Aging is growing up: celebrating the latest research in aging and senescence biology	13
Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer	12
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	12
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	12
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	12
The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	12