OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
NDF is a transcription factor that stimulates elongation by RNA polymerase II	317
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	159
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	117
Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae	111
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	106
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	84
ALL-tRNAseq enables robust tRNA profiling in tissue samples	84
ASCL1 represses a SOX9⁺ neural crest stem-like state in small cell lung cancer	80
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	65
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	63
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation	57
A nonneural miRNA cluster mediates hearing via repression of two neural targets	56
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex	55
How do genomes encode developmental time?	54
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	53
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	52
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	49
CDK4loss-of-function mutations cause microcephaly and short stature	49
The evolving tale of Pol2 function	49
Notch induces transcription by stimulating release of paused RNA polymerase II	47
Metabolic partitioning in the brain and its hijacking by glioblastoma	46
Oct4 redox sensitivity potentiates reprogramming and differentiation	44
The biological underpinnings of therapeutic resistance in pancreatic cancer	42
The evolution of metazoan shelterin	41
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	41

Histone bivalency regulates the timing of cerebellar granule cell development	40
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer	40
Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors	40
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	38
Letters to the Editor	38
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	37
Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies	37
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	35
Tolerance thresholds underlie responses to DNA damage during germline development	35
Opening the window for endothelial-to-hematopoietic transition	35
TBX2 controls a proproliferative gene expression program in melanoma	34
Corrigendum: Identification of a PTEN-regulated STAT₃brain tumor suppressor pathway	33
LINE-1, the NORth star of nucleolar organization	32
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	32
How Terri Grodzicker transformedGenes & Development	31
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	31
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	31
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	31
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	30
REST is a major negative regulator of endocrine differentiation during pancreas organogenesis	30
Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy	29
Cancer neuroscience at the brain–body interface	29
Reflections on Terri	28
BMAL1 drives muscle repair through control of hypoxic NAD⁺ regeneration in satellite cells	28
Traveling with Terri: bacterial communities	28
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	28
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	28
Multiomics analysis of the NAD⁺–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	27
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	27
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	27
TG andG&D: some thoughts and reminiscences	26
NEAT1 promotes genome stability via m⁶A methylation-dependent regulation of CHD4	26
A germline PAF1 paralog complex ensures cell type-specific gene expression	26
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	26
An Editor's rave review	26
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	26
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	25
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	25
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation	25
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	23
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	23
Transcription factors specifically control change	23
Features and mechanisms of canonical and noncanonical genomic imprinting	22
Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain	21
Therapeutic targeting of RNA for neurological and neuromuscular disease	21
Introduction: 35 years on	21
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	20
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	20
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	20
SPOC domain proteins in health and disease	19

Guide RNA acrobatics: the one-for-two shuffle	19
From fat to fear: how lipid powers cancer spread	19
Spore germination: Two ion channels are better than one	19
The area postrema: a critical mediator of brain–body interactions	18
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	18
Circadian de(regulation) in physiology: implications for disease and treatment	18
Genetic cold cases: lessons from solving complex congenital limb disorders	18
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	18
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	17
Bridging brain and body in cancer	17
The lncRNAMalat1is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	16
The inner workings of replisome-dependent control of DNA damage tolerance	16
Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	16
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	16
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	16
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	16
Small RNAs guide histone methylation in Arabidopsis embryos	15
Targeting the m⁶A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication	15
Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression	15
Terri Grodzicker: the quintessential scientist–Editor	15
Genes and my development	15
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	15
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	15
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus	15