OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Senescence and the SASP: many therapeutic avenues	532
Genetic and biological hallmarks of colorectal cancer	187
Context-dependent functional compensation between Ythdf m⁶A reader proteins	153
Chronic tissue inflammation and metabolic disease	131
Cells of origin of lung cancers: lessons from mouse studies	109
Roles of vimentin in health and disease	97
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	89
Targeting the m⁶A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication	80
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function	76
The roles and regulation of MDM2 and MDMX: it is not just about p53	69
DNA repair defects in cancer and therapeutic opportunities	66
TFs for TEs: the transcription factor repertoire of mammalian transposable elements	65
RNA polymerase III transcription as a disease factor	63
Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome	61
The biological underpinnings of therapeutic resistance in pancreatic cancer	60
Interfaces between cellular responses to DNA damage and cancer immunotherapy	60
p53 directly represses human LINE1 transposons	59
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks	58
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells	57
Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis	56
p53 tetramerization: at the center of the dominant-negative effect of mutant p53	56
Hepatic transcriptional responses to fasting and feeding	55
Transient genomic instability drives tumorigenesis through accelerated clonal evolution	54
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription	53
MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity	51

The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing	49
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation	48
Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription	47
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline	47
The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation	47
Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2	47
Break-induced replication promotes fragile telomere formation	44
Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization	44
WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis	43
Time is of the essence: the molecular mechanisms of primary microcephaly	43
Natural temperature fluctuations promote COOLAIR regulation of FLC	42
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome	42
The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization	40
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis	40
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	40
Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore	39
Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum	39
Epitranscriptomic addition of m⁶A regulates HIV-1 RNA stability and alternative splicing	39
BMP signaling: at the gate between activated melanocyte stem cells and differentiation	39
Features and mechanisms of canonical and noncanonical genomic imprinting	39
The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole	38
Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis	38
ASCL1 represses a SOX9⁺ neural crest stem-like state in small cell lung cancer	38
The DNA replication fork suppresses CMG unloading from chromatin before termination	37
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts	36
The missing linker: emerging trends for H1 variant-specific functions	36
Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation	36
Interorganelle communication, aging, and neurodegeneration	36
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression	36
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma	35
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	34
Small RNAs guide histone methylation in Arabidopsis embryos	34
RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress	33
Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster	33
Translational regulation by uORFs and start codon selection stringency	33
Killing SCLC: insights into how to target a shapeshifting tumor	33
Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins	32
The evolution of metazoan shelterin	32
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex	31
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma	31
ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP	31
Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression	30
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets	30
The end protection problem—an unexpected twist in the tail	30
Mutant p53 in cell-cell interactions	30
SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability	30
Role of 53BP1 in end protection and DNA synthesis at DNA breaks	29
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex	29
Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP6	29
PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction	28

Distinct kinesin motors drive two types of maize neocentromeres	28
SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells	28
YTHDC2 control of gametogenesis requires helicase activity but not m⁶A binding	28
miR760 regulates ATXN1 levels via interaction with its 5′ untranslated region	27
A most formidable arsenal: genetic technologies for building a better mouse	27
Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis	27
The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance	27
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21	26
Polycomb complexes redundantly maintain epidermal stem cell identity during development	26
The Daam2–VHL–Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation	25
Nucleolar-based Dux repression is essential for embryonic two-cell stage exit	25
The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter–enhancer looping	25
A role for alternative splicing in circadian control of exocytosis and glucose homeostasis	24
SPRED proteins and their roles in signal transduction, development, and malignancy	24
A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver	24
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer	24
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex	24
Genetic basis of chemical communication in eusocial insects	24
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic	23
Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells	22
Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice	22
Essential histone chaperones collaborate to regulate transcription and chromatin integrity	22
The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly	22
FGF signaling regulates development by processes beyond canonical pathways	22
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	22