OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Senescence and the SASP: many therapeutic avenues	596
Genetic and biological hallmarks of colorectal cancer	219
Chronic tissue inflammation and metabolic disease	151
Roles of vimentin in health and disease	111
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	93
Targeting the m⁶A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication	90
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function	87
DNA repair defects in cancer and therapeutic opportunities	82
The roles and regulation of MDM2 and MDMX: it is not just about p53	79
The biological underpinnings of therapeutic resistance in pancreatic cancer	69
TFs for TEs: the transcription factor repertoire of mammalian transposable elements	67
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells	64
Interfaces between cellular responses to DNA damage and cancer immunotherapy	63
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks	62
Hepatic transcriptional responses to fasting and feeding	60
Transient genomic instability drives tumorigenesis through accelerated clonal evolution	59
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline	49
Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription	49
Time is of the essence: the molecular mechanisms of primary microcephaly	47
Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization	47
BMP signaling: at the gate between activated melanocyte stem cells and differentiation	46
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome	45
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis	45
Natural temperature fluctuations promote COOLAIR regulation of FLC	44
WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis	44

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	43
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma	41
Features and mechanisms of canonical and noncanonical genomic imprinting	41
Translational regulation by uORFs and start codon selection stringency	41
ASCL1 represses a SOX9⁺ neural crest stem-like state in small cell lung cancer	41
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts	40
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets	40
Epitranscriptomic addition of m⁶A regulates HIV-1 RNA stability and alternative splicing	39
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	39
Interorganelle communication, aging, and neurodegeneration	39
RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress	38
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression	38
Small RNAs guide histone methylation in Arabidopsis embryos	38
The missing linker: emerging trends for H1 variant-specific functions	38
Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation	38
Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster	36
Killing SCLC: insights into how to target a shapeshifting tumor	36
Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP6	34
Mutant p53 in cell-cell interactions	33
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	33
The evolution of metazoan shelterin	33
Role of 53BP1 in end protection and DNA synthesis at DNA breaks	32
Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins	32
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma	32
YTHDC2 control of gametogenesis requires helicase activity but not m⁶A binding	32
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex	31
PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction	31
Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression	31
The end protection problem—an unexpected twist in the tail	30
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex	30
Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis	30
Polycomb complexes redundantly maintain epidermal stem cell identity during development	29
SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells	29
Nucleolar-based Dux repression is essential for embryonic two-cell stage exit	29
RNA granules: functional compartments or incidental condensates?	29
The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter–enhancer looping	28
The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance	27
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic	27
The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly	26
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21	26
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex	26
Genetic basis of chemical communication in eusocial insects	26
A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver	25
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	25
SPRED proteins and their roles in signal transduction, development, and malignancy	25
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer	25
Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells	24
Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease	24
Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice	24
Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release	23

Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual	23
Essential histone chaperones collaborate to regulate transcription and chromatin integrity	22
An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia	22
Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities	22
FGF signaling regulates development by processes beyond canonical pathways	22
Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression	22
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer	22
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	22
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation	21
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation	21
Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells	21
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance	21
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	21
DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivity	21
Early behavioral and molecular events leading to caste switching in the ant Harpegnathos	21
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus	21
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	21
ALL-tRNAseq enables robust tRNA profiling in tissue samples	20
USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer	20
Mutant p53 regulates Survivin to foster lung metastasis	20
Isoform-specific functions of PPARγ in gene regulation and metabolism	19
Dietary interventions as regulators of stem cell behavior in homeostasis and disease	19
Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice	19
ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes	19
XPO7 is a tumor suppressor regulating p21^CIP1-dependent senescence	19