Genes & Development

(The TQCC of Genes & Development is 61. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Recent insights into the function of autophagy in cancer497
Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences329
Genetics and biology of pancreatic ductal adenocarcinoma322
Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation253
Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer212
Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2212
MITF—the first 25 years188
Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice.180
Host–transposon interactions: conflict, cooperation, and cooption162
PRC2 is high maintenance149
Role of tumor and host autophagy in cancer metabolism148
Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities147
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes147
p53 genes function to restrain mobile elements145
Nuclear position dictates DNA repair pathway choice142
Pericellular proteolysis in cancer137
DNA replication origins—where do we begin?132
DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination132
Identification of senescent cell surface targetable protein DPP4132
Transcription-mediated replication hindrance: a major driver of genome instability130
53BP1: a DSB escort129
The impact of mitotic errors on cell proliferation and tumorigenesis124
Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling124
Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program120
The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions111
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes109
ZNF445 is a primary regulator of genomic imprinting106
Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD5299
Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer97
Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element96
Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP193
High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain93
CD44 splice isoform switching determines breast cancer stem cell state90
The Integrator complex cleaves nascent mRNAs to attenuate transcription88
MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer85
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans79
Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer–enhancer interactions78
Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis78
A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin77
Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis77
Kidney organoids: accurate models or fortunate accidents76
The epidermis coordinates auxin-induced stem growth in response to shade76
Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization75
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix74
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage74
Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis73
Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+–NFAT signaling72
Helix–loop–helix proteins and the advent of cellular diversity: 30 years of discovery69
RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening69
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation69
Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis68
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity67
ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression66
A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes64
Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis63
An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion63
The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo363
ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation63
Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells62
Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer61
Hypoxia drives transient site-specific copy gain and drug-resistant gene expression61