OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
ALL-tRNAseq enables robust tRNA profiling in tissue samples	180
Timing is everything: transcription bursting in development	137
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	129
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	104
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	74
A nonneural miRNA cluster mediates hearing via repression of two neural targets	73
NDF is a transcription factor that stimulates elongation by RNA polymerase II	69
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	56
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	53
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	51
How do genomes encode developmental time?	49
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	48
Notch induces transcription by stimulating release of paused RNA polymerase II	47
The evolving tale of Pol2 function	47
Metabolic partitioning in the brain and its hijacking by glioblastoma	45
Cohesin in 3D: development, differentiation, and disease	45
Oct4 redox sensitivity potentiates reprogramming and differentiation	45
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	44
CDK4loss-of-function mutations cause microcephaly and short stature	43
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	41
Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors	40
Letters to the Editor	39
A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate	39
Histone bivalency regulates the timing of cerebellar granule cell development	38
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	37

USP7 substrates identified by proteomics analysis reveal the specificity of USP7	37
Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies	36
The evolution of metazoan shelterin	36
LINE-1, the NORth star of nucleolar organization	35
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	34
Corrigendum: Identification of a PTEN-regulated STAT₃brain tumor suppressor pathway	34
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	34
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	33
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	32
Opening the window for endothelial-to-hematopoietic transition	32
TBX2 controls a proproliferative gene expression program in melanoma	32
Tolerance thresholds underlie responses to DNA damage during germline development	32
How Terri Grodzicker transformedGenes & Development	31
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	31
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	31
Cancer neuroscience at the brain–body interface	29
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	28
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	27
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	27
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	26
Mitochondria dysfunction: cause or consequence of physiologic aging?	26
Traveling with Terri: bacterial communities	25
Reflections on Terri	25
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	25
BMAL1 drives muscle repair through control of hypoxic NAD⁺ regeneration in satellite cells	25
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	24
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	23
NEAT1 promotes genome stability via m⁶A methylation-dependent regulation of CHD4	22
End of the line: a kinetic ruler model for poly(A) tail termination	22
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	22
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	21
Corrigendum: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells	21
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates	20
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	20
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	20
TG andG&D: some thoughts and reminiscences	20
Multiomics analysis of the NAD⁺–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	20
An Editor's rave review	19
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	19
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation	19
Transcription factors specifically control change	18
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations	18
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	18
H3K4me3 amplifies transcription at intergenic active regulatory elements	18
Therapeutic targeting of RNA for neurological and neuromuscular disease	17
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	17
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	17
A germline PAF1 paralog complex ensures cell type-specific gene expression	17
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	17
Introduction: 35 years on	17

Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	17
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	16
Transcription quality control at the promoter-proximal checkpoint	16
The area postrema: a critical mediator of brain–body interactions	16
Circadian de(regulation) in physiology: implications for disease and treatment	16
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	16
From fat to fear: how lipid powers cancer spread	16
Guide RNA acrobatics: the one-for-two shuffle	15
Spore germination: Two ion channels are better than one	15
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	15
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	15
Genetic cold cases: lessons from solving complex congenital limb disorders	14
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	14
SPOC domain proteins in health and disease	14
Aging is growing up: celebrating the latest research in aging and senescence biology	14
Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	14
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	14
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	14
Bridging brain and body in cancer	14
The inner workings of replisome-dependent control of DNA damage tolerance	14
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	14
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	14