Genes & Development

(The TQCC of Genes & Development is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Senescence and the SASP: many therapeutic avenues494
Genetic and biological hallmarks of colorectal cancer171
Context-dependent functional compensation between Ythdf m6A reader proteins148
Chronic tissue inflammation and metabolic disease128
Cells of origin of lung cancers: lessons from mouse studies106
A central role for canonical PRC1 in shaping the 3D nuclear landscape104
Progress toward understanding chromosome silencing by Xist RNA96
Roles of vimentin in health and disease86
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide81
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication80
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication75
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function72
Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation62
The roles and regulation of MDM2 and MDMX: it is not just about p5361
TFs for TEs: the transcription factor repertoire of mammalian transposable elements60
Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome60
Interfaces between cellular responses to DNA damage and cancer immunotherapy60
RNA polymerase III transcription as a disease factor59
p53 directly represses human LINE1 transposons58
p53 tetramerization: at the center of the dominant-negative effect of mutant p5354
The biological underpinnings of therapeutic resistance in pancreatic cancer54
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks54
DNA repair defects in cancer and therapeutic opportunities53
Transient genomic instability drives tumorigenesis through accelerated clonal evolution53
Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis51
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells51
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription49
MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity48
Hepatic transcriptional responses to fasting and feeding47
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation46
The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation46
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs45
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline45
The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing45
Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription44
Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization44
Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI244
Natural temperature fluctuations promote COOLAIR regulation of FLC41
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome40
Break-induced replication promotes fragile telomere formation40
WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis39
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis38
Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum38
The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization38
Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore37
Features and mechanisms of canonical and noncanonical genomic imprinting37
The DNA replication fork suppresses CMG unloading from chromatin before termination37
The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole37
BMP signaling: at the gate between activated melanocyte stem cells and differentiation37
Time is of the essence: the molecular mechanisms of primary microcephaly37
Collapse of the hepatic gene regulatory network in the absence of FoxA factors37
Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis35
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion35
Interorganelle communication, aging, and neurodegeneration35
Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells34
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression34
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts34
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer34
The missing linker: emerging trends for H1 variant-specific functions34
Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation34
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans33
TEX15 associates with MILI and silences transposable elements in male germ cells32
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma32
Small RNAs guide histone methylation in Arabidopsis embryos32
Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins32
Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing32
ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP31
Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation31
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets30
RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress30
Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster30
The evolution of metazoan shelterin30
SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability29
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex29
Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP628
Killing SCLC: insights into how to target a shapeshifting tumor28
Role of 53BP1 in end protection and DNA synthesis at DNA breaks28
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex28
The end protection problem—an unexpected twist in the tail28
Translational regulation by uORFs and start codon selection stringency28
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution27
The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance27
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma27
Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression27
PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction27
Distinct kinesin motors drive two types of maize neocentromeres27
YTHDC2 control of gametogenesis requires helicase activity but not m6A binding26
SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells26
Mutant p53 in cell-cell interactions26
A most formidable arsenal: genetic technologies for building a better mouse26
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF2126
The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter–enhancer looping25
Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis25
Polycomb complexes redundantly maintain epidermal stem cell identity during development25
miR760 regulates ATXN1 levels via interaction with its 5′ untranslated region25
SPRED proteins and their roles in signal transduction, development, and malignancy24
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex24
A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver24
Competition between maturation and degradation drives human snRNA 3′ end quality control24
Genetic basis of chemical communication in eusocial insects23
The Daam2–VHL–Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation23
Nucleolar-based Dux repression is essential for embryonic two-cell stage exit23