OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	172
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	124
A nonneural miRNA cluster mediates hearing via repression of two neural targets	121
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	96
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	94
NDF is a transcription factor that stimulates elongation by RNA polymerase II	72
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	66
Timing is everything: transcription bursting in development	65
ALL-tRNAseq enables robust tRNA profiling in tissue samples	57
Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae	51
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	46
How do genomes encode developmental time?	44
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	44
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	44
The evolving tale of Pol2 function	44
Oct4 redox sensitivity potentiates reprogramming and differentiation	43
Notch induces transcription by stimulating release of paused RNA polymerase II	43
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	42
CDK4loss-of-function mutations cause microcephaly and short stature	42
Cohesin in 3D: development, differentiation, and disease	41
Metabolic partitioning in the brain and its hijacking by glioblastoma	40
Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors	38
Letters to the Editor	38
Histone bivalency regulates the timing of cerebellar granule cell development	37
The evolution of metazoan shelterin	37

Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	36
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	36
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer	34
Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies	34
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	34
Opening the window for endothelial-to-hematopoietic transition	33
LINE-1, the NORth star of nucleolar organization	33
Corrigendum: Identification of a PTEN-regulated STAT₃brain tumor suppressor pathway	33
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	33
Tolerance thresholds underlie responses to DNA damage during germline development	32
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	31
TBX2 controls a proproliferative gene expression program in melanoma	31
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	31
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	31
REST is a major negative regulator of endocrine differentiation during pancreas organogenesis	31
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	31
How Terri Grodzicker transformedGenes & Development	31
Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy	29
Cancer neuroscience at the brain–body interface	29
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	28
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	27
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	27
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	26
Reflections on Terri	26
Mitochondria dysfunction: cause or consequence of physiologic aging?	26
BMAL1 drives muscle repair through control of hypoxic NAD⁺ regeneration in satellite cells	26
Traveling with Terri: bacterial communities	26
Multiomics analysis of the NAD⁺–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	24
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	23
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	23
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	22
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	22
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	22
TG andG&D: some thoughts and reminiscences	21
An Editor's rave review	21
NEAT1 promotes genome stability via m⁶A methylation-dependent regulation of CHD4	21
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	20
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation	20
Introduction: 35 years on	19
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	19
Transcription factors specifically control change	19
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	19
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	19
A germline PAF1 paralog complex ensures cell type-specific gene expression	19
Therapeutic targeting of RNA for neurological and neuromuscular disease	18
From fat to fear: how lipid powers cancer spread	18
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	18
Spore germination: Two ion channels are better than one	18
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	18
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	17

The area postrema: a critical mediator of brain–body interactions	17
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	17
Guide RNA acrobatics: the one-for-two shuffle	17
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	17
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	16
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	16
Circadian de(regulation) in physiology: implications for disease and treatment	16
The inner workings of replisome-dependent control of DNA damage tolerance	16
Genetic cold cases: lessons from solving complex congenital limb disorders	16
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	16
SPOC domain proteins in health and disease	16
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	15
The lncRNAMalat1is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	15
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	15
Terri Grodzicker: the quintessential scientist–Editor	14
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	14
Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression	14
Aging is growing up: celebrating the latest research in aging and senescence biology	14
Bridging brain and body in cancer	14
Genes and my development	14
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	14