Genes & Development

Papers
(The TQCC of Genes & Development is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Senescence and the SASP: many therapeutic avenues421
PARP and PARG inhibitors in cancer treatment339
Structure and mechanism of the RNA polymerase II transcription machinery158
The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions149
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling146
Genetic and biological hallmarks of colorectal cancer138
Context-dependent functional compensation between Ythdf m6A reader proteins137
(ADP-ribosyl)hydrolases: structure, function, and biology118
Chronic tissue inflammation and metabolic disease111
Cells of origin of lung cancers: lessons from mouse studies101
A central role for canonical PRC1 in shaping the 3D nuclear landscape97
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs90
Progress toward understanding chromosome silencing by Xist RNA87
PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis86
Cerebral organoid and mouse models reveal a RAB39b–PI3K–mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes86
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide77
Nuclear PARPs and genome integrity76
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication73
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication66
Roles of vimentin in health and disease65
Interplay between compartmentalized NAD+ synthesis and consumption: a focus on the PARP family63
Autophagy promotes mammalian survival by suppressing oxidative stress and p5361
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function61
Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres60
Estrogen-related receptors are targetable ROS sensors60
Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation59
Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome57
TFs for TEs: the transcription factor repertoire of mammalian transposable elements55
The roles and regulation of MDM2 and MDMX: it is not just about p5355
The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism55
Interfaces between cellular responses to DNA damage and cancer immunotherapy54
RNA polymerase III transcription as a disease factor53
p53 directly represses human LINE1 transposons53
p53 tetramerization: at the center of the dominant-negative effect of mutant p5351
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks51
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription47
The biological underpinnings of therapeutic resistance in pancreatic cancer46
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells45
Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis45
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline44
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation44
MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity43
The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation43
Molecular structures and mechanisms of DNA break processing in mouse meiosis43
Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links43
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs42
DNA repair defects in cancer and therapeutic opportunities40
Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization40
The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing40
Hepatic transcriptional responses to fasting and feeding39
Break-induced replication promotes fragile telomere formation38
Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI238
Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model37
Natural temperature fluctuations promote COOLAIR regulation of FLC36
The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole36
4E-T-bound mRNAs are stored in a silenced and deadenylated form36
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome36
WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis35
Critical roles of phosphoinositides and NF2 in Hippo pathway regulation35
Collapse of the hepatic gene regulatory network in the absence of FoxA factors35
Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore34
The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization33
The DNA replication fork suppresses CMG unloading from chromatin before termination33
Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum33
Features and mechanisms of canonical and noncanonical genomic imprinting33
BMP signaling: at the gate between activated melanocyte stem cells and differentiation33
Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis33
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts32
TEX15 associates with MILI and silences transposable elements in male germ cells32
The missing linker: emerging trends for H1 variant-specific functions31
ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP31
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer31
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis31
Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis31
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression31
Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells31
Time is of the essence: the molecular mechanisms of primary microcephaly31
Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing30
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion30
Interorganelle communication, aging, and neurodegeneration29
Small RNAs guide histone methylation in Arabidopsis embryos29
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans29
Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation29
Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins28
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets27
RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress27
REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors27
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex27
The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance27
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma27
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma26
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex26
Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster26
The end protection problem—an unexpected twist in the tail26
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution25
miR760 regulates ATXN1 levels via interaction with its 5′ untranslated region25
Mutant p53 in cell-cell interactions25
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF2125
The evolution of metazoan shelterin25
Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP625
Role of 53BP1 in end protection and DNA synthesis at DNA breaks25
The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter–enhancer looping24
Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis24
Polycomb complexes redundantly maintain epidermal stem cell identity during development24
Targeted chemotherapy overcomes drug resistance in melanoma24
Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression24
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