Genes & Development

Article	Citations
Senescence and the SASP: many therapeutic avenues	596
Genetic and biological hallmarks of colorectal cancer	219
Chronic tissue inflammation and metabolic disease	151
Roles of vimentin in health and disease	111
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	93
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication	90
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function	87
DNA repair defects in cancer and therapeutic opportunities	82
The roles and regulation of MDM2 and MDMX: it is not just about p53	79
The biological underpinnings of therapeutic resistance in pancreatic cancer	69
TFs for TEs: the transcription factor repertoire of mammalian transposable elements	67
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells	64
Interfaces between cellular responses to DNA damage and cancer immunotherapy	63
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks	62
Hepatic transcriptional responses to fasting and feeding	60
Transient genomic instability drives tumorigenesis through accelerated clonal evolution	59
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline	49
Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription	49
Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization	47
Time is of the essence: the molecular mechanisms of primary microcephaly	47
BMP signaling: at the gate between activated melanocyte stem cells and differentiation	46
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis	45
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome	45
WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis	44
Natural temperature fluctuations promote COOLAIR regulation of FLC	44

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	43
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma	41
Features and mechanisms of canonical and noncanonical genomic imprinting	41
Translational regulation by uORFs and start codon selection stringency	41
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer	41
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts	40
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets	40
Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing	39
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	39
Interorganelle communication, aging, and neurodegeneration	39
RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress	38
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression	38
Small RNAs guide histone methylation in Arabidopsis embryos	38
The missing linker: emerging trends for H1 variant-specific functions	38
Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation	38
Killing SCLC: insights into how to target a shapeshifting tumor	36
Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster	36
Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP6	34
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	33
The evolution of metazoan shelterin	33
Mutant p53 in cell-cell interactions	33
Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins	32
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma	32
YTHDC2 control of gametogenesis requires helicase activity but not m6A binding	32
Role of 53BP1 in end protection and DNA synthesis at DNA breaks	32
PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction	31
Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression	31
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex	31
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex	30
Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis	30
The end protection problem—an unexpected twist in the tail	30
SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells	29
Nucleolar-based Dux repression is essential for embryonic two-cell stage exit	29
RNA granules: functional compartments or incidental condensates?	29
Polycomb complexes redundantly maintain epidermal stem cell identity during development	29
The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter–enhancer looping	28
The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance	27
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic	27
The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly	26
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21	26
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex	26
Genetic basis of chemical communication in eusocial insects	26
A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver	25
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	25
SPRED proteins and their roles in signal transduction, development, and malignancy	25
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer	25
Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease	24
Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice	24
Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells	24
Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release	23

Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual	23
FGF signaling regulates development by processes beyond canonical pathways	22
Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression	22
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer	22
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	22
Essential histone chaperones collaborate to regulate transcription and chromatin integrity	22
An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia	22
Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities	22
Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells	21
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	21
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance	21
DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivity	21
Early behavioral and molecular events leading to caste switching in the ant Harpegnathos	21
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	21
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus	21
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation	21
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation	21
USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer	20
Mutant p53 regulates Survivin to foster lung metastasis	20
ALL-tRNAseq enables robust tRNA profiling in tissue samples	20
Isoform-specific functions of PPARγ in gene regulation and metabolism	19
Dietary interventions as regulators of stem cell behavior in homeostasis and disease	19
Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice	19
ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes	19
XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence	19
Primary cilia control translation and the cell cycle in medulloblastoma	18
A six-amino-acid motif is a major determinant in functional evolution of HOX1 proteins	18
Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain	18
BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells	18
Divergent evolution toward sex chromosome-specific gene regulation inDrosophila	18
The dual nature of the nucleolus	18
The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas	18
Human nucleoli comprise multiple constrained territories, tethered to individual chromosomes	18
Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems	18
Distinct histone H3–H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones	17
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	17
YAP–VGLL4 antagonism defines the major physiological function of the Hippo signaling effector YAP	17
Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma	17
Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes	17
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	17
Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	17
Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions	17
REST is a major negative regulator of endocrine differentiation during pancreas organogenesis	17
CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart	17
Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans	17
Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior	16
Establishing and maintaining fertility: the importance of cell cycle arrest	15
Enzymatic reactions of AGO4 in RNA-directed DNA methylation: siRNA duplex loading, passenger strand elimination, target RNA slicing, and sliced target retention	15
RBM33 directs the nuclear export of transcripts containing GC-rich elements	15
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	15
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia	15
CST–Polα/Primase: the second telomere maintenance machine	15
Peripheral clocks tick independently of their master	15
Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform	14
MED1 is a lipogenesis coactivator required for postnatal adipose expansion	14
Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development	14
Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2	14
Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer	14
Dynamics in Fip1 regulate eukaryotic mRNA 3′ end processing	14
Natural antisense transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock	14
Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans	14
Cell and chromatin transitions in intestinal stem cell regeneration	13
Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	13
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis	13
Noncanonical imprinting sustains embryonic development and restrains placental overgrowth	12
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	12
Functional interaction between the RNA exosome and the sirtuin deacetylase Hst3 maintains transcriptional homeostasis	12
A new role for the synaptonemal complex in the regulation of meiotic recombination	12
Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology	12
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation	12
PLK1 regulates CtIP and DNA2 interplay in long-range DNA end resection	11
Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I	11
LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunities	11
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	11
Structure and DNA-bridging activity of the essential Rec114–Mei4 trimer interface	11
Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signaling	11
Single-molecule identification of the target RNAs of different RNA binding proteins simultaneously in cells	11
A myocardin-adjacent lncRNA balances SRF-dependent gene transcription in the heart	11
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	11
Enhancers, gene regulation, and genome organization	11

Intrinsically disordered protein regions are required for cell wall homeostasis inBacillus subtilis	11
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response	11
Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci	11
Highly rigid H3.1/H3.2–H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells	11
Modeling congenital heart disease: lessons from mice, hPSC-based models, and organoids	10
Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity	10
Centriole signaling restricts hepatocyte ploidy to maintain liver integrity	10
Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells	10
Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies	10
Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae	10
KLF5 governs sphingolipid metabolism and barrier function of the skin	9
Substrate-dependent effects of quaternary structure on RNase E activity	9
Histone bivalency regulates the timing of cerebellar granule cell development	9
Coupling crossover and synaptonemal complex in meiosis	9
Localization ofKif1cmRNA to cell protrusions dictates binding partner specificity of the encoded protein	9
Upstream open reading frames control PLK4 translation and centriole duplication in primordial germ cells	9
Topography of histone H3–H4 interaction with the Hat1–Hat2 acetyltransferase complex	9
Evolutionary conservation of the structure and function of meiotic Rec114−Mei4 and Mer2 complexes	9
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells	9
Sexually dimorphic DNA damage responses and mutation avoidance in the mouse germline	9
TBX2 controls a proproliferative gene expression program in melanoma	9
PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance	9
Kinesin-1 captures RNA cargo in its adaptable coils	9
Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions	9
Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity	9
Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance	8
BMAL1 dephosphorylation determines the pace of the circadian clock	8
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	8
AGO HITS-CLIP reveals distinct miRNA regulation of white and brown adipose tissue identity	8
Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity	8
Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas	8
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	8
Developmentally regulated alternate 3′ end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage	8
Solving the chromosome puzzle of aneuploidy in cancer	8
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia	7
Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues	7
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	7
Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice	7
The alternative macrophage relay: STAT6 passes the baton to EGR2	7
Delineation of two multi-invasion-induced rearrangement pathways that differently affect genome stability	7
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	7
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	7
Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals	7
Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy	7
Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast	7
Oxytocin signaling is necessary for synaptic maturation of adult-born neurons	7
Restrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription	7