Genes & Development

Article	Citations
A nonneural miRNA cluster mediates hearing via repression of two neural targets	151
Corrigendum: Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38	111
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	108
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	102
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	67
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	62
Timing is everything: transcription bursting in development	57
Coordination of nuclear RNA processing by speckle-localized kinase TAOK2	51
ALL-tRNAseq enables robust tRNA profiling in tissue samples	45
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	42
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	41
How do genomes encode developmental time?	38
The evolving tale of Pol2 function	38
CDK4loss-of-function mutations cause microcephaly and short stature	37
Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion	36
Notch induces transcription by stimulating release of paused RNA polymerase II	34
Metabolic partitioning in the brain and its hijacking by glioblastoma	34
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3	34
Cohesin in 3D: development, differentiation, and disease	34
Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state	34
Oct4 redox sensitivity potentiates reprogramming and differentiation	33
TET1 noncatalytic activity shapes the chromatin landscape associated with de novo methylation establishment in the male germline	31
A lncRNA drives developmentally timed decay of all members of an essential microRNA family	29
Lights up on the embryonic dance: tools and applications of optogenetics in developmental biology	29
A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fat	29

Letters to the Editor	29
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	29
The Bcl11–Cxxc1 axis regulates stage-specific chromatin accessibility during lymphocyte development	28
Histone bivalency regulates the timing of cerebellar granule cell development	27
Corrigendum: Identification of a PTEN-regulated STAT3brain tumor suppressor pathway	27
The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity	26
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	26
LINE-1, the NORth star of nucleolar organization	26
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	25
Tolerance thresholds underlie responses to DNA damage during germline development	25
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	24
Mutant p53: evolving perspectives	24
How Terri Grodzicker transformedGenes & Development	23
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	23
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	23
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	23
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	23
Independent control of neurogenesis and dorsoventral patterning by NKX2-2	23
Cancer neuroscience at the brain–body interface	23
Rethinking HNF1A-MODY: HNF1A at the crossroads of development and multiorgan metabolic disease	22
A brain-specific microRNA, miR-1000 , regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster	21
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	21
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	21
Mitochondria dysfunction: cause or consequence of physiologic aging?	21
Reflections on Terri	20
Multiomic analysis of clonal development reveals new regulators of leukemic cell growth	20
End of the line: a kinetic ruler model for poly(A) tail termination	20
Traveling with Terri: bacterial communities	20
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	19
NEAT1 promotes genome stability via m 6 A methylation-dependent regulation of CHD4	19
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates	18
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	17
Corrigendum: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells	17
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	17
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	16
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	16
Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer	16
An Editor's rave review	16
TG andG&D: some thoughts and reminiscences	16
Mechanisms coordinating exit from the stem cell state in mammals	15
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations	15
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	15
Transcription factors specifically control change	15
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	15
A germline PAF1 paralog complex ensures cell type-specific gene expression	15
H3K4me3 amplifies transcription at intergenic active regulatory elements	14
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	13
Introduction: 35 years on	13
Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex	13
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	13

BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	13
Rewiring gene circuits to dissect oscillatory signaling dynamics	13
Therapeutic targeting of RNA for neurological and neuromuscular disease	13
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	13
Transcription quality control at the promoter-proximal checkpoint	12
SPOC domain proteins in health and disease	12
The area postrema: a critical mediator of brain–body interactions	12
Spore germination: Two ion channels are better than one	12
The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons	12
From fat to fear: how lipid powers cancer spread	12
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	12
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	11
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	11
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	11
Modeling medulloblastoma pathogenesis and treatment in human cerebellar organoids	11
Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	11
MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice	11
Circadian de(regulation) in physiology: implications for disease and treatment	11
Genetic cold cases: lessons from solving complex congenital limb disorders	11
Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer	11
Aging is growing up: celebrating the latest research in aging and senescence biology	11
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	10
Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli	10
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	10
The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	10
Terri Grodzicker: the quintessential scientist–Editor	10
Bridging brain and body in cancer	10
Genes and my development	10
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	10
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	9
LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells	9
Pan-cellular organelles and suborganelles—from common functions to cellular diversity?	9
Chromosome organization by fine-tuning an ATPase	9
Temporal loss of En1 during limb development causes distinct phenotypes	9
Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression	9
Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing	9
KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity	9
Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance	9
Greg Hannon: the scientist who changed biology, and the people who practiced it	9
Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus	9
Drosha: a new tumor suppressor in pineoblastoma	8
A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle	8
Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50–IκBζ pathway	8
Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo	8
Structure and DNA-bridging activity of the essential Rec114–Mei4 trimer interface	8
Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer	8
Structure, function, regulation, evolution, and therapeutic implications of PARP14	8
Igf2 regulates early postnatal DPP4 + preadipocyte pool expansion	8
Classifying the molecular functions of transcription factors beyond activation and repression	8
Diverse influences on tau aggregation and implications for disease progression	7
Decoding biology with massively parallel reporter assays and machine learning	7
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	7
Neural stem cell epigenomes and fate bias are temporally coordinated during mouse cortical development	7
Corrigendum: The evolutionary turnover of recombination hot spots contributes to speciation in mice	7
Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination	7
The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation	7
Beyond the usual suspects: expanding aging research from classic models to really cool critters	7
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin	7
PWWP mutants of the transcriptional cofactor JASPer divert promoter and enhancer activities and suppress position effect variegation in Drosophila	7
TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions	7
Making a journal great: an ode to Terri Grodzicker	7
A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies	7
CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning	6
DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids	6
What a wonderful world!	6
Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development	6
DDX3X-mediated translation of structured cardiac mRNAs is essential for female heart development	6
Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks	6
Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma	6
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	6
Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma	6
Terri Grodzicker and the making ofGenes & Development	6
Studying ovarian aging and its health impacts: modern tools and approaches	6
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules	5
CST–Polα/Primase: the second telomere maintenance machine	5
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells	5
Histone bivalency in CNS development	5
B-lineage commitment is dependent on a reversible epigenetic switch	5
Designer genes courtesy of artificial intelligence	5
Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis	5

Where and why have so many metabolic enzymes gone from developing spores ofBacillus subtilis?	5
Linking miRNAs to decay	5
Molecular and cellular dynamics of squamous cell carcinomas across tissues	5
Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship	5
Terri Grodzicker: Editor, leader, and friend	5
Synchronization of the segmentation clock using synthetic cell–cell signaling	5
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis	5
Corrigendum: Sept4 /ARTS is required for stem cell apoptosis and tumor suppression	5
Letter to the Editor	5
The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe	5
Analysis of theDrosophilaand human DPR elements reveals a distinct human variant whose specificity can be enhanced by machine learning	5
Nonhomologous end joining—the importance of end tethering and beyond	5
Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies	5
HeterozygousRPA2variant as a novel genetic cause of telomere biology disorders	5
The two faces of MyoD: repressor and activator of gene expression during myogenesis	5
Imaging the binding of MECP2 to DNA	4
Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR	4
An Editor scientists dream of	4
Terri Grodzicker: advocate and influencer of impactful science	4
Isoform–paralog specificity and tissue-dependent vulnerabilities in neurological disorders	4
Sex-specific transcriptome dynamics of Anopheles gambiae during embryonic development	4
Mouse cortical cellular diversification through lineage progression of radial glia	4
Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease	4
Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast	4
Evolutionarily conserved spliceosome–exosome pathway in nuclear mRNA surveillance	4
Cancer mortality and senescence: Is redox therapy an option?	4
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia	4
Terri Grodzicker: 35 years of shaping scientific publishing and communication	4
Putting a finger on histidine methylation	4
The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels	4
TRF1 uses a noncanonical function of TFIIH to promote telomere replication	4
MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress	4
“Undruggable KRAS”: druggable after all	4
Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness	4
My pearl anniversary withGenes & Development,30 years on…	3
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry	3
YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity	3
Allelic chromatin structure precedes imprinted expression ofKcnk9during neurogenesis	3
MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival	3
Folding makes an imprint	3
ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation	3
Comparing the roles of sex chromosome-encoded protein homologs in gene regulation	3
Modeling YAP fusions: a paradigm for investigating rare cancers?	3
MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1-dependent TGF-β signaling	3
In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g	3
Totipotency, development, and chromatin	3
An FGF timer for zygotic genome activation	3
Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer	3
Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development	3
The microprotein SMIM26 connects metabolite transporters of the outer and inner mitochondrial membranes and is essential for respiratory chain function	3
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth	3
Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions	3