Genes & Development

Article	Citations
Senescence and the SASP: many therapeutic avenues	475
Structure and mechanism of the RNA polymerase II transcription machinery	165
Genetic and biological hallmarks of colorectal cancer	157
Context-dependent functional compensation between Ythdf m6A reader proteins	144
Chronic tissue inflammation and metabolic disease	121
Cells of origin of lung cancers: lessons from mouse studies	106
A central role for canonical PRC1 in shaping the 3D nuclear landscape	101
Progress toward understanding chromosome silencing by Xist RNA	93
Roles of vimentin in health and disease	80
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide	80
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	78
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function	70
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication	70
Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation	61
TFs for TEs: the transcription factor repertoire of mammalian transposable elements	60
Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome	60
Interfaces between cellular responses to DNA damage and cancer immunotherapy	59
The roles and regulation of MDM2 and MDMX: it is not just about p53	58
RNA polymerase III transcription as a disease factor	57
p53 directly represses human LINE1 transposons	57
p53 tetramerization: at the center of the dominant-negative effect of mutant p53	54
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks	54
Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis	49
The biological underpinnings of therapeutic resistance in pancreatic cancer	49
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells	49

Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription	49
Transient genomic instability drives tumorigenesis through accelerated clonal evolution	49
DNA repair defects in cancer and therapeutic opportunities	48
MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity	46
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline	45
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs	45
Molecular structures and mechanisms of DNA break processing in mouse meiosis	45
Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links	45
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation	44
Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription	44
The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation	44
Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization	43
Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2	43
Hepatic transcriptional responses to fasting and feeding	42
The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing	41
WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis	39
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome	39
Natural temperature fluctuations promote COOLAIR regulation of FLC	39
The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization	38
Break-induced replication promotes fragile telomere formation	38
4E-T-bound mRNAs are stored in a silenced and deadenylated form	38
The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole	37
Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum	37
BMP signaling: at the gate between activated melanocyte stem cells and differentiation	36
Features and mechanisms of canonical and noncanonical genomic imprinting	36
Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore	36
Collapse of the hepatic gene regulatory network in the absence of FoxA factors	36
The DNA replication fork suppresses CMG unloading from chromatin before termination	36
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis	35
Time is of the essence: the molecular mechanisms of primary microcephaly	35
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	34
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts	34
Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis	34
The missing linker: emerging trends for H1 variant-specific functions	33
Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation	33
Interorganelle communication, aging, and neurodegeneration	33
Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells	33
Small RNAs guide histone methylation in Arabidopsis embryos	32
Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins	32
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer	32
TEX15 associates with MILI and silences transposable elements in male germ cells	32
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression	32
ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP	31
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	31
Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation	31
Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing	30
Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster	30
REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors	28
The end protection problem—an unexpected twist in the tail	28
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex	28

RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress	28
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets	27
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma	27
SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability	27
Role of 53BP1 in end protection and DNA synthesis at DNA breaks	27
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution	27
The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance	27
Distinct kinesin motors drive two types of maize neocentromeres	27
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex	27
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma	27
Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP6	26
The evolution of metazoan shelterin	26
Mutant p53 in cell-cell interactions	26
Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis	25
SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells	25
Polycomb complexes redundantly maintain epidermal stem cell identity during development	25
PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction	25
miR760 regulates ATXN1 levels via interaction with its 5′ untranslated region	25
Killing SCLC: insights into how to target a shapeshifting tumor	25
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21	25
A most formidable arsenal: genetic technologies for building a better mouse	25
YTHDC2 control of gametogenesis requires helicase activity but not m6A binding	25
Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression	25
Targeted chemotherapy overcomes drug resistance in melanoma	24
The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter–enhancer looping	24
The Daam2–VHL–Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation	23
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex	23
Competition between maturation and degradation drives human snRNA 3′ end quality control	23
Essential histone chaperones collaborate to regulate transcription and chromatin integrity	22
A role for alternative splicing in circadian control of exocytosis and glucose homeostasis	22
A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver	22
Nucleolar-based Dux repression is essential for embryonic two-cell stage exit	22
Translational regulation by uORFs and start codon selection stringency	22
Genetic basis of chemical communication in eusocial insects	21
SPRED proteins and their roles in signal transduction, development, and malignancy	21
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer	21
PRIM1 deficiency causes a distinctive primordial dwarfism syndrome	20
The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly	20
FGF signaling regulates development by processes beyond canonical pathways	20
HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity	20
Mutant p53 regulates Survivin to foster lung metastasis	19
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic	19
Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells	19
Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities	19
In vivo CRISPR screening for phenotypic targets of themir-35-42family inC. elegans	19
An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia	18
Dietary interventions as regulators of stem cell behavior in homeostasis and disease	18
Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain	18
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation	18
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation	18
Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells	17
Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice	17
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	17
Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease	17
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	17
Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release	17
Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual	17
The spatial regulation of condensin activity in chromosome condensation	17
Early behavioral and molecular events leading to caste switching in the ant Harpegnathos	16
Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation	16
DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivity	16
A six-amino-acid motif is a major determinant in functional evolution of HOX1 proteins	16
USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer	16
Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression	16
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus	16
Distinct histone H3–H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones	15
CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart	15
The dual nature of the nucleolus	15
EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism	15
Isoform-specific functions of PPARγ in gene regulation and metabolism	15
Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans	15
ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes	15
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer	15
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	15
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia	14
Primary cilia control translation and the cell cycle in medulloblastoma	14
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	14
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance	14
Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice	14
Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	14

The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas	14
A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals	14
Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems	14
RNA granules: functional compartments or incidental condensates?	13
REST is a major negative regulator of endocrine differentiation during pancreas organogenesis	13
Divergent evolution toward sex chromosome-specific gene regulation inDrosophila	13
Establishing and maintaining fertility: the importance of cell cycle arrest	13
Natural antisense transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock	13
ALL-tRNAseq enables robust tRNA profiling in tissue samples	13
BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells	13
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	13
Dynamics in Fip1 regulate eukaryotic mRNA 3′ end processing	13
RBM33 directs the nuclear export of transcripts containing GC-rich elements	12
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	12
Peripheral clocks tick independently of their master	12
Enzymatic reactions of AGO4 in RNA-directed DNA methylation: siRNA duplex loading, passenger strand elimination, target RNA slicing, and sliced target retention	12
Twist-dependent ratchet functioning downstream from Dorsal revealed using a light-inducible degron	12
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	12
Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans	12
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	12
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	11
Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes	11
Human nucleoli comprise multiple constrained territories, tethered to individual chromosomes	11
Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma	11
Noncanonical imprinting sustains embryonic development and restrains placental overgrowth	11
Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior	11
Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	11
Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform	11
Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development	11
Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signaling	11
Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer	11
Highly rigid H3.1/H3.2–H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells	10
A new role for the synaptonemal complex in the regulation of meiotic recombination	10
Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions	10
Molecular mechanism for the interaction between human CPSF30 and hFip1	10
Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae	10
A myocardin-adjacent lncRNA balances SRF-dependent gene transcription in the heart	10
YAP–VGLL4 antagonism defines the major physiological function of the Hippo signaling effector YAP	10
Point-activated ESR1Y541S has a dramatic effect on the development of sexually dimorphic organs	10
Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2	9
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis	9
XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence	9
Phf21b imprints the spatiotemporal epigenetic switch essential for neural stem cell differentiation	9
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation	9
Enhancers, gene regulation, and genome organization	9
MED1 is a lipogenesis coactivator required for postnatal adipose expansion	9
Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons	9
Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity	9
Cell and chromatin transitions in intestinal stem cell regeneration	9
Substrate-dependent effects of quaternary structure on RNase E activity	9
Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology	9
Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I	9
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response	9