Genes & Development

Article	Citations
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	133
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	101
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	92
A nonneural miRNA cluster mediates hearing via repression of two neural targets	90
Corrigendum: Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38	61
ALL-tRNAseq enables robust tRNA profiling in tissue samples	61
Timing is everything: transcription bursting in development	58
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	53
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	49
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	48
Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion	48
Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state	41
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	40
Metabolic partitioning in the brain and its hijacking by glioblastoma	40
The evolving tale of Pol2 function	40
Notch induces transcription by stimulating release of paused RNA polymerase II	39
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3	38
Oct4 redox sensitivity potentiates reprogramming and differentiation	35
How do genomes encode developmental time?	35
CDK4loss-of-function mutations cause microcephaly and short stature	34
Cohesin in 3D: development, differentiation, and disease	34
A lncRNA drives developmentally timed decay of all members of an essential microRNA family	34
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	34
Lights up on the embryonic dance: tools and applications of optogenetics in developmental biology	32
Letters to the Editor	31

USP7 substrates identified by proteomics analysis reveal the specificity of USP7	31
A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fat	28
Corrigendum: Identification of a PTEN-regulated STAT3brain tumor suppressor pathway	27
Histone bivalency regulates the timing of cerebellar granule cell development	27
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	27
LINE-1, the NORth star of nucleolar organization	27
Tolerance thresholds underlie responses to DNA damage during germline development	26
The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity	26
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	25
Mutant p53: evolving perspectives	25
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	25
How Terri Grodzicker transformedGenes & Development	24
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	24
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	23
Cancer neuroscience at the brain–body interface	23
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	23
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	22
A brain-specific microRNA, miR-1000 , regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster	22
Independent control of neurogenesis and dorsoventral patterning by NKX2-2	22
Rethinking HNF1A-MODY: HNF1A at the crossroads of development and multiorgan metabolic disease	22
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	22
Mitochondria dysfunction: cause or consequence of physiologic aging?	22
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	22
Traveling with Terri: bacterial communities	21
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	21
End of the line: a kinetic ruler model for poly(A) tail termination	21
Corrigendum: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells	21
Reflections on Terri	21
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	21
Multiomics analysis of the NAD+–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	20
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates	20
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	20
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	20
Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer	20
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	20
An Editor's rave review	19
NEAT1 promotes genome stability via m 6 A methylation-dependent regulation of CHD4	19
TG andG&D: some thoughts and reminiscences	19
Multiomic analysis of clonal development reveals new regulators of leukemic cell growth	19
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	18
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	18
A germline PAF1 paralog complex ensures cell type-specific gene expression	18
H3K4me3 amplifies transcription at intergenic active regulatory elements	18
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	18
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations	17
Transcription factors specifically control change	17
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	16
Spore germination: Two ion channels are better than one	16
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	16
Introduction: 35 years on	16

Circadian de(regulation) in physiology: implications for disease and treatment	16
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	15
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	15
SPOC domain proteins in health and disease	15
The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons	14
Rewiring gene circuits to dissect oscillatory signaling dynamics	14
The area postrema: a critical mediator of brain–body interactions	14
Transcription quality control at the promoter-proximal checkpoint	14
Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex	14
From fat to fear: how lipid powers cancer spread	14
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	14
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	14
Therapeutic targeting of RNA for neurological and neuromuscular disease	13
Aging is growing up: celebrating the latest research in aging and senescence biology	13
Genetic cold cases: lessons from solving complex congenital limb disorders	13
Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	13
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	13
Bridging brain and body in cancer	13
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	13
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	12
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	12
The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	12
Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer	12
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	12
Terri Grodzicker: the quintessential scientist–Editor	11
Genes and my development	11
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	11
Modeling medulloblastoma pathogenesis and treatment in human cerebellar organoids	11
Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance	11
LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells	10
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus	10
KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity	10
Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression	10
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	10
Temporal loss of En1 during limb development causes distinct phenotypes	10
Chromosome organization by fine-tuning an ATPase	9
Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing	9
Pan-cellular organelles and suborganelles—from common functions to cellular diversity?	9
Structure and DNA-bridging activity of the essential Rec114–Mei4 trimer interface	9
Drosha: a new tumor suppressor in pineoblastoma	9
Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli	9
Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus	9
Beyond the usual suspects: expanding aging research from classic models to really cool critters	9
Igf2 regulates early postnatal DPP4 + preadipocyte pool expansion	8
Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer	8
A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle	8
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin	8
DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids	8
A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies	8
Classifying the molecular functions of transcription factors beyond activation and repression	8
Corrigendum: The evolutionary turnover of recombination hot spots contributes to speciation in mice	8
Neural stem cell epigenomes and fate bias are temporally coordinated during mouse cortical development	8
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance	8
Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50–IκBζ pathway	8
Structure, function, regulation, evolution, and therapeutic implications of PARP14	8
Diverse influences on tau aggregation and implications for disease progression	8
Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo	8
Making a journal great: an ode to Terri Grodzicker	8
Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma	7
TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions	7
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	7
Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma	7
Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination	7
Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma	6
DDX3X-mediated translation of structured cardiac mRNAs is essential for female heart development	6
Decoding biology with massively parallel reporter assays and machine learning	6
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells	6
The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation	6
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	6
What a wonderful world!	6
Terri Grodzicker and the making ofGenes & Development	6
Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development	6
Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks	6
Where and why have so many metabolic enzymes gone from developing spores ofBacillus subtilis?	5
Studying ovarian aging and its health impacts: modern tools and approaches	5
The two faces of MyoD: repressor and activator of gene expression during myogenesis	5
The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe	5
Histone bivalency in CNS development	5
Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis	5
HeterozygousRPA2variant as a novel genetic cause of telomere biology disorders	5

Letter to the Editor	5
CST–Polα/Primase: the second telomere maintenance machine	5
Linking miRNAs to decay	5
Analysis of theDrosophilaand human DPR elements reveals a distinct human variant whose specificity can be enhanced by machine learning	5
Nonhomologous end joining—the importance of end tethering and beyond	5
Designer genes courtesy of artificial intelligence	5
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules	5
Molecular and cellular dynamics of squamous cell carcinomas across tissues	5
Corrigendum: Sept4 /ARTS is required for stem cell apoptosis and tumor suppression	5
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis	5
Terri Grodzicker: Editor, leader, and friend	5
Putting a finger on histidine methylation	5
Sex-specific transcriptome dynamics of Anopheles gambiae during embryonic development	4
Modeling YAP fusions: a paradigm for investigating rare cancers?	4
The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels	4
Cancer mortality and senescence: Is redox therapy an option?	4
An Editor scientists dream of	4
Mouse cortical cellular diversification through lineage progression of radial glia	4
“Undruggable KRAS”: druggable after all	4
MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival	4
Primary cilia control translation and the cell cycle in medulloblastoma	4
Synchronization of the segmentation clock using synthetic cell–cell signaling	4
Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast	4
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia	4
Terri Grodzicker: 35 years of shaping scientific publishing and communication	4
Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness	4
Imaging the binding of MECP2 to DNA	4
B-lineage commitment is dependent on a reversible epigenetic switch	4
Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies	4
Terri Grodzicker: advocate and influencer of impactful science	4
TRF1 uses a noncanonical function of TFIIH to promote telomere replication	4
Allelic chromatin structure precedes imprinted expression ofKcnk9during neurogenesis	3
ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation	3
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry	3
An FGF timer for zygotic genome activation	3
A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage	3
Restrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription	3
Totipotency, development, and chromatin	3
YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity	3
Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development	3
My pearl anniversary withGenes & Development,30 years on…	3
The interplay between senescence, inflammation, and the immune system	3
Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer	3
Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation	3
Speed of life: tuning the ticktock of the segmentation clock	3
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response	3
Folding makes an imprint	3
In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g	3
Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions	3
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth	3
NFATC2IP is a mediator of SUMO-dependent genome integrity	3
Comparing the roles of sex chromosome-encoded protein homologs in gene regulation	3
Terri Grodzicker and her guidance through the elegance of adenovirus genetics	3
Nuclear receptor coregulator interactions: beyond the switch	3
MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1-dependent TGF-β signaling	3
The microprotein SMIM26 connects metabolite transporters of the outer and inner mitochondrial membranes and is essential for respiratory chain function	3