Genes & Development

Article	Citations
Folding makes an imprint	243
In vivo temporal resolution of acute promyelocytic leukemia progression reveals a role of Klf4 in suppressing early leukemic transformation	164
Comparing the roles of sex chromosome-encoded protein homologs in gene regulation	121
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	98
Interfaces between cellular responses to DNA damage and cancer immunotherapy	90
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	90
Arrested development: the dysfunctional life history of medulloblastoma	87
NDF is a transcription factor that stimulates elongation by RNA polymerase II	79
Making a journal great: an ode to Terri Grodzicker	71
TG andG&D: some thoughts and reminiscences	70
An Editor's rave review	65
My pearl anniversary withGenes & Development,30 years on…	63
Totipotency, development, and chromatin	62
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	59
Corrigendum: In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans	58
Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae	51
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	47
DiverseFgfr1signaling pathways and endocytic trafficking regulate mesoderm development	45
Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain	45
Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain	44
Features and mechanisms of canonical and noncanonical genomic imprinting	44
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation	43
Molecular basis for PHF7-mediated ubiquitination of histone H3	41
Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans	41
Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems	41

The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	41
A nonneural miRNA cluster mediates hearing via repression of two neural targets	40
A germline PAF1 paralog complex ensures cell type-specific gene expression	40
Decoding biology with massively parallel reporter assays and machine learning	39
Interoceptive inference and prediction in food-related disorders	39
Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks	39
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation	38
Psat1-generated α-ketoglutarate and glutamine promote muscle stem cell activation and regeneration	38
Transcription factors specifically control change	36
Mesenchymal stromal cells as conductors of adipose tissue remodeling	36
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex	36
Regularly spaced tyrosines in EBF1 mediate BRG1 recruitment and formation of nuclear subdiffractive clusters	34
Dynamics in Fip1 regulate eukaryotic mRNA 3′ end processing	33
Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity	33
Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells	32
Corrigendum: Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination	32
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	32
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response	31
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	31
Peripheral clocks tick independently of their master	30
Localization ofKif1cmRNA to cell protrusions dictates binding partner specificity of the encoded protein	30
Disruption of origin chromatin structure by helicase activation in the absence of DNA replication	30
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry	30
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	29
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	29
Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer	28
Single-molecule identification of the target RNAs of different RNA binding proteins simultaneously in cells	26
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	26
Corrigendum: The evolutionary turnover of recombination hot spots contributes to speciation in mice	26
Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals	26
An old dog with new tricks: TFEB promotes syncytin expression and cell fusion in the human placenta	25
Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs	25
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer	24
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	24
An FGF timer for zygotic genome activation	24
Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development	23
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation	23
Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions	23
ALL-tRNAseq enables robust tRNA profiling in tissue samples	22
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	22
Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma	22
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	22
Metabolic partitioning in the brain and its hijacking by glioblastoma	21
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	21
Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing	21
ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation	21
Enzymatic reactions of AGO4 in RNA-directed DNA methylation: siRNA duplex loading, passenger strand elimination, target RNA slicing, and sliced target retention	21
Erratum: Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I	21
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	21
The evolving tale of Pol2 function	20

Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	20
Intron lariat spliceosomes convert lariats to true circles: implications for intron transposition	20
Protein domains of low sequence complexity—dark matter of the proteome	19
It's complicated: the interplay ofKif1cmRNA localization in cell protrusions, assembly of protein binding partners on the KIF1C protein, and cell migration	19
NFATC2IP is a mediator of SUMO-dependent genome integrity	19
SPOC domain proteins in health and disease	19
Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer	18
Coupling crossover and synaptonemal complex in meiosis	18
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	18
The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly	18
The dual nature of the nucleolus	18
Guide RNA acrobatics: the one-for-two shuffle	18
Terri Grodzicker and the making ofGenes & Development	17
Epigenetic modulators provide a path to understanding disease and therapeutic opportunity	17
You can be an editor too!	17
A synthetic KLHL20 ligand to validate CUL3KLHL20as a potent E3 ligase for targeted protein degradation	17
Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster	17
A model for Scc2p stimulation of cohesin's ATPase and its inhibition by acetylation of Smc3p	17
Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity	17
Terri Grodzicker and her guidance through the elegance of adenovirus genetics	17
Introduction: 35 years on	17
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	16
Oct4 redox sensitivity potentiates reprogramming and differentiation	15
How do genomes encode developmental time?	15
Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma	15
Learning from the worm: the effectiveness of protein-bound Moco to treat Moco deficiency	15
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells	15
Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons	15
Corrigendum: Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication	15
Goldilocks meets Polycomb	14
A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage	14
Endothelial cells give a boost to senescence surveillance	14
Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I	14
Mutant p53 in cell-cell interactions	14
Winter fields antisense RNAs to kick off flowering	14
Therapeutic targeting of RNA for neurological and neuromuscular disease	14
Getting under the skin of Polycomb-dependent gene regulation	13
Restrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription	13
Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	13
ADNP modulates SINE B2-derived CTCF-binding sites during blastocyst formation in mice	13
Molecular and cellular dynamics of squamous cell carcinomas across tissues	12
Harnessing brain–body communication to understand cancer	12
The area postrema: a critical mediator of brain–body interactions	12
What a wonderful world!	12
Transient genomic instability drives tumorigenesis through accelerated clonal evolution	11
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	11
Yeast ORC sumoylation status fine-tunes origin licensing	11
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex	11
CST–Polα/Primase: the second telomere maintenance machine	11
Early behavioral and molecular events leading to caste switching in the ant Harpegnathos	11
The roles and regulation of MDM2 and MDMX: it is not just about p53	11
Time is of the essence: the molecular mechanisms of primary microcephaly	11
Polycomb complexes redundantly maintain epidermal stem cell identity during development	11
XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence	11
Killing SCLC: insights into how to target a shapeshifting tumor	11
CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum	11
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	11
Spore germination: Two ion channels are better than one	10
The biological underpinnings of therapeutic resistance in pancreatic cancer	10
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules	10
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets	10
Notch induces transcription by stimulating release of paused RNA polymerase II	10
Kinesin-1 captures RNA cargo in its adaptable coils	10
Circadian de(regulation) in physiology: implications for disease and treatment	10
Uncovering a mammalian neural-specific poly(A) binding protein with unique properties	10
Human nucleoli comprise multiple constrained territories, tethered to individual chromosomes	9
YAP–VGLL4 antagonism defines the major physiological function of the Hippo signaling effector YAP	9
Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis	9
Isoform-specific functions of PPARγ in gene regulation and metabolism	9
The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter–enhancer looping	9
Long ant life span is maintained by a unique heat shock factor	9
Analysis of theDrosophilaand human DPR elements reveals a distinct human variant whose specificity can be enhanced by machine learning	9
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis	9
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	9
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	9
Intrinsically disordered protein regions are required for cell wall homeostasis inBacillus subtilis	9
Letters to the Editor	8
mTORC1, the maestro of cell metabolism and growth	8
The inner workings of replisome-dependent control of DNA damage tolerance	8
Letter to the Editor	8

Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38	8
Terri andG&D: celebrating 50 years of enlightened scientific judgment	8
MYC through the lens ofG&D	8
Cell type-specific role of CBX2 and its disordered region in spermatogenesis	8
A tribute to Terri Grodzicker from an admirer	7
Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells	7
A cellular identity crisis? Plasticity changes during aging and rejuvenation	7
Cisinteractions in theIrf8locus regulate stage-dependent enhancer activation	7
Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	7
Corrigendum: UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide	7
Bridging brain and body in cancer	7
Corrigendum: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice	7
Genetic cold cases: lessons from solving complex congenital limb disorders	7
Nucleolar-based Dux repression is essential for embryonic two-cell stage exit	7
Temperature matters: the potential impact of thermoregulatory mechanisms in brain–body physiology	7
Human pre-mRNA 3′ end processing: reconstituting is believing	6
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	6
Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual	6
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	6
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	6
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer	6
A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks	6
Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors	6
MED1 is a lipogenesis coactivator required for postnatal adipose expansion	5
AGO HITS-CLIP reveals distinct miRNA regulation of white and brown adipose tissue identity	5
Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues	5
Translational regulation by uORFs and start codon selection stringency	5
YTHDC2 control of gametogenesis requires helicase activity but not m6A binding	5
Alternative splicing controls pan-neuronal homeobox gene expression	5
The lncRNAMalat1is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	5
NKX2.2 and KLF4 cooperate to regulate α-cell identity	5
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	5
The evolution of metazoan shelterin	5
Evolutionary conservation of the structure and function of meiotic Rec114−Mei4 and Mer2 complexes	4
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma	4
ChAHP2 and ChAHP control diverse retrotransposons by complementary activities	4
Small RNAs guide histone methylation in Arabidopsis embryos	4
Histone bivalency regulates the timing of cerebellar granule cell development	4
Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology	4
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome	4
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	4
PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance	4
Oxytocin signaling is necessary for synaptic maturation of adult-born neurons	4
A disproportionate impact of G9a methyltransferase deficiency on the X chromosome	4
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	4
Deciphering normal and cancer stem cell niches by spatial transcriptomics: opportunities and challenges	4
Divergent evolution toward sex chromosome-specific gene regulation inDrosophila	4
Chronic tissue inflammation and metabolic disease	4