OOIR: Observatory of International Research

Papers

(The H4-Index of Genes & Development is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Senescence and the SASP: many therapeutic avenues	596
Genetic and biological hallmarks of colorectal cancer	219
Chronic tissue inflammation and metabolic disease	151
Roles of vimentin in health and disease	111
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	93
Targeting the m⁶A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication	90
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function	87
DNA repair defects in cancer and therapeutic opportunities	82
The roles and regulation of MDM2 and MDMX: it is not just about p53	79
The biological underpinnings of therapeutic resistance in pancreatic cancer	69
TFs for TEs: the transcription factor repertoire of mammalian transposable elements	67
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells	64
Interfaces between cellular responses to DNA damage and cancer immunotherapy	63
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks	62
Hepatic transcriptional responses to fasting and feeding	60
Transient genomic instability drives tumorigenesis through accelerated clonal evolution	59
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline	49
Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription	49
Time is of the essence: the molecular mechanisms of primary microcephaly	47
Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization	47
BMP signaling: at the gate between activated melanocyte stem cells and differentiation	46
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome	45
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis	45
Natural temperature fluctuations promote COOLAIR regulation of FLC	44
WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis	44

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	43
ASCL1 represses a SOX9⁺ neural crest stem-like state in small cell lung cancer	41
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma	41
Features and mechanisms of canonical and noncanonical genomic imprinting	41
Translational regulation by uORFs and start codon selection stringency	41
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets	40
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts	40
Interorganelle communication, aging, and neurodegeneration	39
Epitranscriptomic addition of m⁶A regulates HIV-1 RNA stability and alternative splicing	39
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	39
The missing linker: emerging trends for H1 variant-specific functions	38
Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation	38
RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress	38
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression	38
Small RNAs guide histone methylation in Arabidopsis embryos	38